@tome V2.1
Ref.
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Doc.
Global output mode :
Group entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Selected Ligands Contact
Catalytic Site Atlas
Show alignment :
Best alignments
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
Structural Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Modeller Score
Verify3D Model Score
QMean Model Score
Hide column
Complexes Prediction
Show Ligands of Templates
Comparative Docking Score
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Comparative Docking Tab
Atome Color :
Mutated
Helix
Strand
Conserved
Query sequence : >T0653: (2012-05-07 )
MNKIISIIALLLILPIFKVEAYDFVIDEITYNFTKEHGTVEVSGLREFLNLEPGDRNSSLPLVVNIPPVVTYKDNKYDVVSIGYAAFQGCRKVTEIKIPSTVREIGEFAFENCSKLEIINIPDSVKMIGRCTFSGCYALKSILLPLMLKSIGVEAFKGCDFKEITIPEGVTVIGDEAFATCESLEYVSLPDSMETLHNGLFSGCGKLKSIKLPRNLKIIRDYCFAECILLENMEFPNSLYYLGDFALSKTGVKNIIIPDSFTELGKSVFYGCTDLESISIQNNKLRIGGSLFYNCSGLKKVIYGSVIVPEKTFYGCSSLTEVKLLDSVKFIGEEAFESCTSLVSIDLPYLVEEIGKRSFRGCTSLSNINFPLSLRKIGANAFQGCINLKKVELPKRLEQYRYDFEDTTKFKWIK
Atome Classification :
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MNKIISI----IALLLILPIFKVEA-Y-DF-VIDEITYNFTKEHGTVEVS-------------G----L-REFLNLEPGDRNSSLPLVVNIP-----PVVTYKDNKY-DVVSIGYAAFQGCRKVTEIKI-P-S-T-V-RE--IG-EFAFENCSKLE-----IINI-PD-S--VKMI-GRCTFSGCYAL----KS--IL----L-P-L-M-LKSIGVEAFKG---C-D------------------------------FKEITI-----PE-----------------------------------------------------G--------------------------------VTVIGD---------------------------EAFATC--E--SLEYVSLP-D---S-MET--LHNGLFSGCGK------------------------LKSIKLPR-N----LKIIRDY-------------------CFA----ECILLENMEF----------PN----S-L--YYLG---DFALSK---------T-GVKNIII-PD------S-FTELG--KSVFYGCTDLESISIQN-N-K--L-R-I-GGS-LFYNCSGLKKV-IYGS---V---I-----------V---------------------P-----E--KTFYGCSSLTEVKL-L-D----S-V-K--FI--------G---EEAFE------SCTSLVSI---------------------------DLP--Y-L---V-E-----E-IGK------RSFRG----CTSLSNINF-P-----L-S-LRKIGANAFQG-CINLKKVELPK-R-LEQYR-Y-D-F-------------E-DTT-KFKWIK------------------------------------------------------------------------------------
13
Fugue
83.54
15%
-102.45
- C3 -
1XKU
3
PGS2_BOVIN
A:
[22-326]
-------------------------------------------------------------------------
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----------------------------------------------------------------------------------------------------------------------------------------
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-----------------------------------------------------------------------------------------------------------------------------
23
SP3
79.31
10%
-108.87
- C3 -
1XCD
5
PGS2_BOVIN
A:
[22-326]
---------------------------------------------------------------------------------------------------------------------
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-----------------------------------------------------
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-------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
73.71
15%
-120.21
- C3 -
2ID5
7
LIGO1_HUMAN
A:
[1-477]
--------------------------------------
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ILDSNPLACDC----------------
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S-----------------------------------
24
SP3
73.32
11%
-129.50
- C3 -
1O6S
4
INLA_LISMO
A:
[6-465]
------------------------------------------------------------------------
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39
HHSearch
72.46
17%
-103.31
- C3 -
3T6Q
15
CD180_MOUSE
A:
[51-526]
----------------------------------------
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D
L
A
F
---
T
---
R
L
K
V
K
-------
D
---------------------
A
-----
Q
--
S
P
F
Q
N
L
H
L
L
K
V
L
N
L
-
S
-
H
----
S
L
L
-
D
--
I
S
--------
S
---
E
Q
L
F
D
------
G
L
P
A
L
Q
H
L
---------------------------
N
L
Q
--
G
-
N
H--
F
-
P
KG---
N
-
I
Q
K
T-----
N
S
L
Q
T
----
L
G
R
L
E
I
L
V
L
-
S
-----
F
-
C
D
L
S
S
I
D
Q
H
A
F
T
S
-
L
K
M
M
N
H
V
D
L
S
H
-
N
R
L
T
S
S
S
I
E
-
A
-
L
-------------
S
-
H
L
K
-
G
I
----------------------------------------------------------------------------------------
14
Fugue
72.02
12%
-98.49
- C3 -
2Z64
10
TLR4_MOUSE
A:
[1-599]
PCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLS
F
N
P
L
K
I
L
KSYS
F
S
N
F
S
E
L
Q
W
L
D
L
S
R
-
C
-
E
I
E
T
I
E
D
K
A
W
H
G
L
H
H
L
S
N
L
I
L
T
GNPIQSFSPGSFS
G
----
L
-
T
S
L
E
N
L
V
A
V
E
T
K
L
A
S
L
E
S
F
P
I
G
QLITL
K
K
L
N
V
A
H
N
F
I
-
H
S
C
K
L
P
-
A
Y
F
S
N
L
T
N
L
V
H
V
D
L
-
S
-
Y
N
Y
-
I
-
Q
T
--
I
T
-
V
N
D
L
Q
F
L
R
E
N
P
Q
V
N
L
S
L
D
M
S
-
L
N
-
P
--
I
D
F
I
-
Q
D
Q
A
F
Q
G
I
K
L
H
----
E
L
--
T
L
R
GNF
N
-
S
-
S
-
N
-
I
M
K
T
C
L
Q
N
L
A
G
---
L
-
H
------------------------------
V
H
R
L
I
L
G
E
F
KD
E
R
-----------------------------------------------------
N
--------------------------------
L
E
I
F
E
P
---------------------------
S
I
M
E
G
L
--
C
DV
T
I
D
E
F
R
L
T
-
Y
T--
N
-
D
F
S
--
D
D
I
V
K
F
H
C
L
A
N
------------------------
V
S
A
M
S
L
A
G
-
V
SIKY
L
E
D
V
P
K
H
-------------------
F
K
W
----
Q
S
L
S
I
I
R
C
Q
L
----------
K
Q
F
P
T
L
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-
L
--
P
F
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K
---
S
L
T
L
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NK
G
S
I
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F
K
K
V
-
A
L
P
S
L
S
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-
L
D
L
S
RNA
L
S
-
F
S
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C
C
--
S
Y
S
D
L
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T
N
S
L
R
H
L
D
L
S
F
-
N
-
G
--
A
-
I
-
I
-
M
S
A
-
N
F
M
G
L
E
E
L
Q
H
L
D
F
Q
H
S
---
T
---
L
-----------
K
---------------------
R
-----
V
--
T
E
F
S
A
F
L
S
L
E
K
L
L
Y
-
L
-
D
ISYT
N
-
T
-
K
--
I
D
--------
F
---
D
G
I
F
L
------
G
L
T
S
L
N
T
L
---------------------------
K
M
A
GN
S
-
F
---
K
-
D
-----
N
-
T
L
S
------
N
V
F
A
N
----
T
T
N
L
T
F
L
D
L
S
K
-----
C
-
Q
-
L
E
Q
I
S
W
G
V
F
D
T
-
L
H
R
L
Q
L
L
N
M
S
H
N
N
-
L
L
F
L
D
-
S
-
S
H
Y
-------------
N
-
Q
L
Y
-
S
L
S
T
L
D
CSFNRIE
T
S
K
G
ILQHFPKSLAFFNLTN
N
S
V
A
CICEH
Q
K
F
L
Q
W
V
K
E
Q
KQFLVNVEQ
M
T
C
A
T
PVEMNTSLVLDFNNSTC-------
4
PsiBlast
72.01
22%
-140.93
- C3 -
1OZN
4
RTN4R_HUMAN
A:
[52-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
A
C
R
N
------------------------
L
T
I
L
W
L
H
S
-
N
V---
L
A
R
I
D
A
A
-------------------
A
F
T
----
G
L
A
L
L
E
Q
L
D
L
SDNAQLRSVD
P
A
----
T
-
F
--
H
G
L
G
RLH
T
L
H
L
D
R
---------
C
-
G
L
Q
-----------------
E
L
G
--
P
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
-
N
-
A
--
L
-
Q
A
L
-
P
D
D
-
T
F
R
D
L
G
N
L
T
H
L
F
L
H
G
N
---
R
---
I
SS---------
V
---------------------
P
-----
E
--
R
A
F
R
G
L
H
S
L
D
R
L
L
L
H
Q
-
N
----
R
-
V
-
A
--
H
V
--------
H
---
P
H
A
F
R
------
D
L
G
R
L
M
T
L
YLFANNLSALPTEALAPLRALQ
Y
L
R
LN
D
N
P
--
W
-
V
---
C
-
D
-----
C
-
R
A
R
P
L
W
A
W
L
Q
K
F
R
G
----
S
S
S
E
V
P
C
S
L
-
P
QRLAG
R
-
D
-
L
K
R
L
A
A
N
D
L
Q
G
-
C
-------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
71.44
14%
-99.60
- C3 -
1M0Z
-
GP1BA_HUMAN
A:
[1-266]
------------------------------------------------------------------------------
H
P
I
C
E
V
S
-------------
K
----
H
-
L
-
E
V
N
C
D
K
R
Q
L
T
A
L
P
P
D
L
P
K
D
T
-----
T
I
L
H
L
S
E
N
L
L
-
Y
T
F
S
--
L
A
T
L
M
P
Y
T
R
L
T
Q
L
N
L
-
D
-
R
-
C
E
L
-
T
K
--
L
Q
---
V
D
G
T
L
P
V
L
G
-----
T
L
D
L
-
S
H
-
N
--
Q
L
Q
S
-
L
P
L
L
G
Q
T
L
P
A
L
----
T
V
--
L
D
----
V
-
S
-
F
N
R
-
L
T
S
L
P
L
G
A
L
R
G
---
L
-
G
E-----------------------------
L
Q
E
L
Y
L
-----
K
G
N----------------------------------------------------
E
--------------------------------
L
K
T
L
P
P
---------------------------
G
L
L
T
P
T
--
P
--
K
L
E
K
L
S
L
A
N
N
---
Q
-
L
T
E
--
L
P
A
G
L
L
N
G
L
E
N
------------------------
L
D
T
L
L
L
Q
E
-
N
S---
L
Y
T
I
P
K
G
-------------------
F
F
G
SHLL
P
F
A
F
L
H
G
N
P
W
----------
L
C
----
N
-
C
--
E
I
L
Y
---
F
R
R
W
L
Q
---------
D
-
N
A
E
N
V
Y
V
-
W
K
------
Q
-
G
V
M
T
S
--
N
V
A
S
V
Q
C
D
N
S
D
K
F
P
V
Y
K
-
Y
-
P
--
G
-
K
-
G
-
C
P
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast
70.72
22%
-146.21
- C3 -
1P8T
2
RTN4R_HUMAN
A:
[51-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
A
C
R
N
------------------------
L
T
I
L
W
L
H
S
-
N
V---
L
A
R
I
D
A
A
-------------------
A
F
T
----
G
L
A
L
L
E
Q
L
D
L
SDNAQLRSVD
P
A
----
T
-
F
--
H
G
L
G
RLH
T
L
H
L
D
R
---------
C
-
G
L
Q
-----------------
E
L
G
--
P
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
-
N
-
A
--
L
-
Q
A
L
-
P
D
D
-
T
F
R
D
L
G
N
L
T
H
L
F
L
H
G
N
---
R
---
I
SS---------
V
---------------------
P
-----
E
--
R
A
F
R
G
L
H
S
L
D
R
L
L
L
H
Q
-
N
----
R
-
V
-
A
--
H
V
--------
H
---
P
H
A
F
R
------
D
L
G
R
L
M
T
L
YLFANNLSALPTEALAPLRALQ
Y
L
R
L
N
D
N
P
--
W
-
V
---
C
-
D
-----
C
-
R
A
R
P
L
W
A
W
L
Q
K
F
R
G
----
S
S
S
E
V
P
C
S
L
-
P
QRLAG
R
-
D
-
L
K
R
L
A
A
N
D
L
Q
G
-
C
-------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
70.20
20%
-89.98
- C3 -
2Z63
2
TLR4_HUMAN
A:
[47-528]
-----------------------------------------
S
----
F
F
S
F
P
E
L
Q
V
L
D
L
S
R
-
C
E
I
Q
-
T
I
E
D
G
A
Y
Q
S
L
S
H
L
S
T
L
I
L
T
-------------
G
----
N
P
I
Q
S
L
A
L
G
A
F
S
G
L
S
S
L
---------------
Q
K
L
V
A
V
E
T
N
L
A
S
L
E
N
F
P
I
G
H
L
K
T
L
K
E
L
N
V
-
A
-
H
-
N
-
L
I
Q
S
--
F
K
L
P
E
Y
F
S
N
L
T
N
L
E
-----
H
L
D
L
-
S
S
-
N
K-
I
Q
S
I
-
Y
C
T
D
L
R
V
L
H
Q
M
PLLN
L
S
--
L
D
----
L
-
S
L
N
-
P
-
M
N
F
I
Q
P
G
A
F
K
E
---
I
-
R
------------------------------
L
H
K
L
T
L
-----
R
N
-----------------------------------------------------
N
FDS
L
N
V
M
K
T
C
I
Q
G
L
AG
L
E
V
H
R
L
V
L
G
E
FRNEGN
L
E
K
F
D
K
SALEGLCNLTIE
E
F
R
L
A
Y
L
DYYLDDII
D
L
F
N
C
L
--
T
--
N
V
S
S
F
S
L
V
-
S
V
--
T
-
I
E
R
--
V
K
D
F
-
S
Y
N
F
-
G
------------------------
W
Q
H
L
E
L
V
N
-
C
K
---
F
G
Q
F
P
T
L
K
L
KSLK
R
L
T
F
TSNKGGNAF
S
E
V
----
D
L
P
S
L
E
F
L
D
L
----------
S
R
----
N
G
L
--
S
F
K
G
CC-
S
Q
S
D
F
G
T--------
T
-
S
L
K
Y
L
D
L
-
S
F
N-----
G
-
V
I
T
M
S
--
S
N
-
F
L
G
L
E
Q
L
E
H
L
D
F
Q
H
-
S
N
L
--
K
Q
M
-
S
-
E
F
S
-
V
F
L
S
L
R
N
L
I
Y
L
-
D
I
S
H
---
T
---
H
T
R
V
--------
A
---------------------
F
-----
N
--
G
I
F
N
G
L
S
S
L
E
V
L
K
M
-
A
-
G
----
N
-
S
-
F
QE
N
F
--------
L
---
P
D
I
F
T
------
E
L
R
N
L
T
F
L
---------------------------
D
L
S
--
Q
C
Q
---
L
-
E
-----
Q
-
L
S
P
------
T
A
F
N
S
----
L
S
S
L
Q
V
L
N
M
-
A
-----
S
N
Q
-
L
K
S
V
P
D
G
I
F
D
R
-
L
T
S
L
Q
K
I
W
L
H
T
-
N
-------------------------------------------------------------------------------------------------------------------------
25
SP3
67.98
10%
-102.52
- C3 -
1OZN
5
RTN4R_HUMAN
A:
[1-284]
--------------------------------------------------------------------------
P
C
P
G
A
C
V
C
Y
N
E
-------------
P
----
K
-
V
T
T
S
C
P
Q
Q
G
L
Q
A
V
P
V
G
I
P
A
A
S
Q
-----
R
---
I
F
L
H
G
N
-
R
I
S
H
V
P
A
A
S
F
R
A
C
R
N
L
T
I
L
W
L
H
S
-
N
-
V
-
L
-
A
R
--
I
D
-
A
A
A
F
T
G
L
A
L
L
E
-----
Q
L
D
L
-
S
D
-
N
AQ
L
R
S
V
-
D
P
A
T
F
H
G
L
G
R
L
----
H
T
--
L
H
----
L
-
D
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R
-
C
G
L
Q
E
L
G
P
G
L
F
R
G
---
L
A
A
------------------------------
L
Q
Y
L
Y
L
-----
Q
D
-----------------------------------------------------
N
A-------------------------------
L
Q
A
L
P
D
---------------------------
D
T
F
R
D
L
--
G
--
N
L
T
H
L
F
L
H
-
G
---
N
R
I
S
S
--
V
P
E
R
A
F
R
G
L
H
S
------------------------
L
D
R
L
L
L
H
Q
-
N
R---
V
A
H
V
H
P
H
-------------------
A
F
R
----
D
L
G
R
L
M
T
L
Y
L
----------
F
A
------------------------------------------
N
------
N
-
L
S
A
L
P
--
T
E
A
L
A
P
L
R
A
L
Q
Y
L
R
L
N
D
-
N
-
P
--
W
-
V
-
C
-
D
C
R
-
A
R
P
L
W
A
W
L
Q
K
F
-
R
G
S
S
---
S
---
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-----------
V
---------------------
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-----
C
--
S
L
P
Q
R
L
A
G
R
-------------
D
-
L
-
K
--
R
L
--------
A
---
A
N
D
L
Q
------
G
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.87
20%
-98.94
- C3 -
1ZIW
4
TLR3_HUMAN
A:
[477-617]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
R
N
L
T
I
L
D
L
S
N
N
N
-
I
--
A
-
N
-
I
-
N
D
D
-
M
L
E
G
L
E
K
L
E
I
L
-
D
L
Q
H
---
N
---
N
LARLWKHANPG
G
---------------------
P
-----
I
--
Y
F
L
K
G
L
S
H
L
H
I
L
N
L
-
E
-
S
N---
G
-
F
-
D
--
E
I
--------
P
---
V
E
V
F
K
------
D
L
F
E
L
K
I
I
---------------------------
D
L
G
--
L
N
N
---
L
-
N
-----
T
-
L
P
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------
S
V
F
N
N
----
Q
V
S
L
K
S
L
N
L
-
Q
-----
K
-
N
L
I
T
S
V
E
K
K
V
F
G
P
A
F
R
N
L
T
E
L
D
M
R
----------------------------------------------------------------------------------------------------------------------------
37
HHSearch
64.83
17%
-82.90
- C3 -
3FXI
4
TLR4_HUMAN
A:
[392-548]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
L
E
Q
L
E
H
L
D
F
Q
H
-
S
N
L
--
K
-
Q
-
M
S
E
F
S
-
V
F
L
S
L
R
N
L
I
Y
L
-
D
I
S
H
---
T
---
H
TRV--------
A
---------------------
F
-----
N
--
G
I
F
N
G
L
S
S
L
E
V
L
K
M
-
A
-
G
----
N
-
S
-
F
QE
N
F
--------
L
---
P
D
I
F
T
------
E
L
R
N
L
T
F
L
---------------------------
D
L
S
--
Q
C
Q
---
L
-
E
-----
Q
-
L
S
P
------
T
A
F
N
S
----
L
S
S
L
Q
V
L
N
M
-
S
-----
H
-
N
N
F
F
S
L
D
T
F
P
Y
K
C
-
L
N
S
L
Q
V
L
D
Y
S
L
-
N
H
I
M
T
S
K
K
Q
-
E
-
L
-------------
Q
-
H
F
P
S
S
L
A
F
L
-------------------------------------------------------------------------------------
5
PsiBlast
64.31
24%
-109.41
- C3 -
3V47
2
?
A:
[260-402]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
K
D
----------
P
D
----
N
-
F
--
T
F
K
G
------
L
E
A
---------
S
-
G
V
K
T
C
D
L
-
S
K
------
S
K
I
F
A
L
L
--
K
S
V
F
S
H
F
T
D
L
E
Q
L
T
L
A
Q
-
N
-
E
--
I
-
N
------------------------------
K
-----------
I
---------------------
D
-----
D
--
N
A
F
W
G
L
T
H
L
L
K
L
N
L
--------
S
-
Q
-
N
--
F
L
--------
G
SID
S
R
M
F
E
------
N
L
D
K
L
E
V
L
---------------------------
D
L
S
--
Y
N
H
---
I
-
R
-----
A
-
L
G
D
------
Q
S
F
L
G
----
L
P
N
L
K
E
L
A
L
-
D
-----
T
-
N
Q
L
K
S
V
P
D
G
I
F
D
R
-
L
T
S
L
Q
K
I
W
L
-----------------------------------------------------------------------------------------------------------------------------
49
HHSearch
61.39
20%
-143.61
- C3 -
2ID5
6
LIGO1_HUMAN
A:
[70-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
-
R
-
S
N
R
-
L
-
K
L
--
I
P
-
L
G
V
F
T
G
L
S
N
L
T
-----
K
L
D
I
-
S
E
N
K
--
I
V
I
L
-
L
D
Y
M
F
Q
D
L
Y
N
L
----
K
S
--
L
E
----
V
-
G
-
D
-
N
D
L
V
Y
I
S
H
R
A
F
S
G
---
L
N
S
------------------------------
L
E
Q
L
T
L
-----
E
K
C----------------------------------------------------
N
--------------------------------
L
T
S
I
P
T
---------------------------
E
A
L
S
H
L
--
H
--
G
L
I
V
L
R
L
R
-
H
L--
N
-
I
N
A
--
I
R
D
Y
S
F
K
R
L
Y
R
LK
V
L
E
I
S
HWPYLDTMTPNCLYGLN
L
T
S
L
S
I
T
H
C
N
----
L
T
A
V
P
Y
L
-------------------
A
V
R
----
H
L
V
Y
L
R
F
L
N
L
----------
S
Y
N---
P
-
I
--
S
T
I
E
---
G
S
M
L
H
E
L--------
L
-
R
L
Q
E
I
Q
L
-
V
G
G-----
Q
-
L
A
V
V
E
--
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
-
N
Q
L
--
T
-
T
-
L
-
E
E
S
-
V
F
H
S
V
G
N
L
E
T
L
-
I
L
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
61.30
17%
-81.98
- C3 -
1ZIW
4
TLR3_HUMAN
A:
[475-614]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
Q
P
L
R
N
L
T
I
L
-
D
L
S
N
---
N
NIA
N
-----------
I
---------------------
N
-----
D
--
D
M
L
E
G
L
E
K
L
E
I
L
D
L
-
Q
-
H
----
N
N
L
-
A
--
R
L
WKHANPGG
P
---
I
Y
F
L
K
------
G
L
S
H
L
H
I
L
---------------------------
N
L
E
--
S
N
G
---
F
-
D
-----
E
-
I
P
V
------
E
V
F
K
D
----
L
F
E
L
K
I
I
D
L
-
G
-----
L
N
N
-
L
N
T
L
P
A
S
V
F
N
N
-
Q
V
S
L
K
S
L
N
L
Q
K
-
N
L
I
T
S
V
E
K
K
-
V
-
F
-------------
G
P
A
F
R
-
N
L
T
E
L
-------------------------------------------------------------------------------------
45
HHSearch
61.18
16%
-92.58
- C3 -
3J0A
4
TLR5_HUMAN
A:
[36-530]
---------------------------------------------------------------
I
R
-
T
V
T
A
S
S
F
P
F
L
E
Q
L
Q
L
L
E
L
G
SQ-----------
Y
----
T
-
P
L
T
I
D
K
E
A
F
R
N
L
P
N
L
R
I
L
D
L
G
S
--------------
S
-
K
I
Y
F
L
H
P
D
A
F
Q
G
L
F
H
L
F
E
L
R
L
-
Y
-
F
-
C
G
L
-
S
D
AV
L
K
-
D
G
Y
F
R
N
L
K
A
L
T
-----
R
L
D
L
-
S
K
-
N
Q-
I
R
S
L
Y
L
H
P
S
F
G
K
L
N
S
L
----
K
S
--
I
D
----
F
-
S
-
S
-
N
Q
I
F
L
V
C
E
H
E
L
E
P
L
Q
G
K
-
T
L
S
F
F
SLAANSLYSRV
S
V
D
W
GKCMNPFRNMV
L
E
I
L
D
V
-----
S
G
NGWT
V
D
I
T
G
N
F
S
N
A
I
SKSQAFSLILAHHIMGAGFGFH----------------
N
--------------------------------
I
K
D
P
D
Q
---------------------------
N
T
F
A
G
L
AR
S
--
S
V
R
H
L
D
L
S
-
H
G--
F
-
V
F
S
--
L
N
S
R
V
F
E
T
L
K
D
------------------------
L
K
V
L
N
L
A
Y
N
K
----
I
N
K
I
A
D
E
-------------------
A
F
Y
----
G
L
D
N
L
Q
V
L
N
L
----------
S
Y
N---
L
-
L
--
G
E
L
Y
---
S
S
N
F
Y
G
---------
L
P
K
V
A
Y
I
D
L
-
Q
K
N-----
H
-
I
A
I
I
Q
--
D
Q
T
F
K
F
L
E
K
L
Q
T
L
D
L
R
D
-
N
A
L
--
T
-
T
-
I
-
H
------
F
I
P
S
I
P
D
I
-
F
L
S
G
---
N
---
K
LV
T
--------
L
P
K
I
N
LTAN
L
I
H
L
S
E
N
R
L
E
NL
D
I
-----
L
--
Y
F
L
L
R
V
P
H
L
Q
I
L
I
L
-
N
-
Q
----
N
-
R
F
S
--
S
C
S-------
G
---
D
Q
T
P
S
------
E
N
P
S
L
E
Q
L
---------------------------
F
L
G
--
E
-
N
M
--
L
-
Q
LAWET
E
-
L
C
W
------
D
V
F
E
G
----
L
S
H
L
Q
V
L
Y
L
-
N
-----
H
-
N
Y
L
N
S
L
P
P
G
V
F
S
H
-
L
T
A
L
R
G
L
S
L
N
S
-
N
R
L
T
V
L
S
-
H
N
D
-
L
-------------
P
---
A
-
N
L
E
I
--------------------------------------------------------------------------------------
44
HHSearch
60.83
21%
-99.80
- C3 -
3T6Q
6
CD180_MOUSE
A:
[269-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
N
-------------------
T
F
H
----
C
F
S
G
L
Q
E
L
D
L
----------
T
A
----
T
H
L
--
S
E
L
P
---
S
G
-
L
V
G
L--------
S
-
T
L
K
K
L
V
L
-
S
A
N-----
K
-
F
E
N
L
C
--
Q
I
S
A
S
N
F
P
S
L
T
H
L
S
I
K
G
-
N
-
T
KR
L
-
E
-
L
-
G
T
G
-
C
L
E
N
L
E
N
L
R
E
L
-
D
L
S
H
---
D
---
D
-----------
I
---------------------
E
TSDCC
N
--
L
Q
L
R
N
L
S
H
L
Q
S
L
N
L
-
S
-
Y
N---
E
-
P
-
L
--
S
L
--------
K
---
T
E
A
F
K
------
E
C
P
Q
L
E
L
L
---------------------------
D
L
A
--
F
-
T
R
--
L
-
K
-----
V
K
D
A
Q
------
S
P
F
Q
N
----
L
H
L
L
K
V
L
N
L
-
S
-----
H
-
S
L
L
D
I
S
S
E
Q
L
F
D
G
-
L
P
A
L
Q
H
L
N
L
Q
G
---------------------------------------------------------------------------------------------------------------------------
40
HHSearch
60.52
17%
-82.57
- C3 -
2Z64
3
TLR4_MOUSE
A:
[372-545]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
H
L
D
L
-
S
F
N-----
G
-
A
I
I
M
S
--
A
N
-
F
M
G
L
E
E
L
Q
H
L
D
F
Q
H
-
S
T
L
--
K
-
R
-
V
-
T
E
F
S
A
F
L
S
L
E
K
L
L
Y
L
-
D
I
S
Y
---
T
---
N
TKI--------
D
---------------------
F
-----
D
--
G
I
F
L
G
L
T
S
L
N
T
L
K
M
-
A
-
G
----
N
-
S
-
F
--
K
D
NT------
L
---
S
N
V
F
A
------
N
T
T
N
L
T
F
L
---------------------------
D
L
S
--
K
C
Q
---
L
-
E
-----
Q
-
I
S
W
------
G
V
F
D
T
----
L
H
R
L
Q
L
L
N
M
-
S
-----
H
-
N
N
L
L
F
L
D
S
S
H
Y
N
Q
-
L
Y
S
L
S
T
L
D
C
S
F
-
N
R
I
E
T
S
K
-
G
I
L
-
Q
-------------
H
-
F
P
K
-
S
L
A
F
F
-------------------------------------------------------------------------------------
38
HHSearch
57.48
15%
-82.60
- C3 -
2Z63
1
TLR4_HUMAN
A:
[366-523]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
S
D
F
G
T
T
S
L
K
Y
L
D
L
S
F
-
N
G
V
--
I
-
T
-
M
-
S
S
N
--
F
L
G
L
E
Q
L
E
H
L
-
D
F
Q
H
---
S
---
N
LKQM-------
S
---------------------
E
-----
F
--
S
V
F
L
S
L
R
N
L
I
Y
L
D
I
-
S
-
H
----
T
H
T
-
R
--
V
A
--------
F
---
N
G
I
F
N
------
G
L
S
S
L
E
V
L
---------------------------
K
M
A
--
G
-
N
---
S
F
Q
E----
N
-
F
L
P
------
D
I
F
T
E
----
L
R
N
L
T
F
L
D
L
-
S
-----
Q
-
C
Q
L
E
Q
L
S
P
T
A
F
N
S
-
L
S
S
L
Q
V
L
N
M
A
S
-
N
Q
L
K
S
V
P
D
G
-
I
-
F
-------------
D
-
R
L
T
-
S
L
Q
K
I
-------------------------------------------------------------------------------------
User Run . : Multi Template Modeling Result:
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKIISIIALLLILPIFKVEAYDFVIDEITYNFTKEHGTVEVSGLREFLNLEPGDRNSSLPLVVNIPPVVTYKDNKYDVVSIGYAAFQGCRKVTEIKIPSTVREIGEFAFENCSKLEIINIPDSVKMIGRCTFSGCYALKSILLPLMLKSIGVEAFKGCDFKEITIPEGVTVIGDEAFATCESLEYVSLPDSMETLHNGLFSGCGKLKSIKLPRNLKIIRDYCFAECILLENMEFPNSLYYLGDFALSKTGVKNIIIPDSFTELGKSVFYGCTDLESISIQNNKLRIGGSLFYNCSGLKKVIYGSVIVPEKTFYGCSSLTEVKLLDSVKFIGEEAFESCTSLVSIDLPYLVEEIGKRSFRGCTSLSNINFPLSLRKIGANAFQGCINLKKVELPKRLEQYRYDFEDTTKFKWIK
68
88.93
100%
-149.87
- C- -
M068
-
A:
[81-445]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
76
88.62
100%
-125.06
- C- -
M076
-
A:
[32-455]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
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L
M
L
K
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I
G
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A
F
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K
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I
T
I
P
E
G
V
T
V
I
G
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A
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A
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L
E
Y
V
S
L
P
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L
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L
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L
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N
L
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C
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C
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L
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L
Y
Y
L
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A
L
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V
K
N
I
I
I
P
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S
F
T
E
L
G
K
S
V
F
Y
G
C
T
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L
E
S
I
S
I
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N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
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K
T
F
Y
G
C
S
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L
T
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V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
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C
T
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L
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S
I
D
L
P
Y
L
V
E
E
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G
K
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F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
71
88.55
100%
-122.14
- C- -
M071
-
A:
[32-455]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
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V
T
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I
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I
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T
V
R
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G
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F
A
F
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N
C
S
K
L
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I
I
N
I
P
D
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V
K
M
I
G
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C
T
F
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Y
A
L
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I
L
L
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A
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A
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A
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L
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L
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L
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L
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S
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N
L
K
I
I
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Y
C
F
A
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C
I
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L
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N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
66
86.69
100%
-146.68
- C- -
M066
-
A:
[81-445]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
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I
G
E
F
A
F
E
N
C
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K
L
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I
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I
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T
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S
G
C
Y
A
L
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L
L
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L
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L
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I
G
V
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A
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I
T
I
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G
V
T
V
I
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A
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A
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L
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L
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M
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L
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L
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G
K
L
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I
K
L
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R
N
L
K
I
I
R
D
Y
C
F
A
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C
I
L
L
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N
M
E
F
P
N
S
L
Y
Y
L
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F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
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K
T
F
Y
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C
S
S
L
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K
L
L
D
S
V
K
F
I
G
E
E
A
F
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S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
62
86.47
100%
-145.48
- C- -
M062
-
A:
[81-477]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
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F
A
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N
C
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L
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I
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C
Y
A
L
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L
L
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L
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A
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A
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A
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L
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M
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L
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L
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G
C
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L
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I
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L
P
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N
L
K
I
I
R
D
Y
C
F
A
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C
I
L
L
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N
M
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F
P
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L
Y
Y
L
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A
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V
K
N
I
I
I
P
D
S
F
T
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L
G
K
S
V
F
Y
G
C
T
D
L
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S
I
S
I
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N
N
K
L
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I
G
G
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L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
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V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
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C
T
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L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
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C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
-----------------------------
60
85.42
100%
-138.07
- C- -
M060
-
A:
[81-477]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
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I
G
E
F
A
F
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N
C
S
K
L
E
I
I
N
I
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M
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C
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A
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L
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L
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L
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G
V
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A
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A
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C
I
L
L
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N
M
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P
N
S
L
Y
Y
L
G
D
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A
L
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K
T
G
V
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N
I
I
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L
G
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S
V
F
Y
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C
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L
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S
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N
N
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G
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L
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N
C
S
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I
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P
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F
Y
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C
S
S
L
T
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V
K
L
L
D
S
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F
I
G
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A
F
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C
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L
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S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
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C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
-----------------------------
75
83.34
100%
-124.02
- C- -
M075
-
A:
[32-422]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
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Y
A
A
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I
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E
I
G
E
F
A
F
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N
C
S
K
L
E
I
I
N
I
P
D
S
-------------
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
------------
V
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A
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A
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C
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F
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C
G
K
L
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I
K
L
P
R
N
L
K
I
I
R
D
----------
N
M
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F
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N
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L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
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F
T
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L
G
K
S
V
F
Y
G
C
T
D
L
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S
I
S
I
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N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
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K
T
F
Y
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C
S
S
L
T
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V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
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S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
63
81.69
100%
-141.55
- C- -
M063
-
A:
[81-477]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
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I
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C
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S
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C
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A
L
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L
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L
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L
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A
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V
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V
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A
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A
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L
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L
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L
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L
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L
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N
M
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F
P
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L
Y
Y
L
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A
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V
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N
I
I
I
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F
T
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L
G
K
S
V
F
Y
G
C
T
D
L
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S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
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V
K
L
L
D
S
V
K
F
I
G
E
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A
F
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S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
-----------------------------
67
80.96
100%
-141.70
- C- -
M067
-
A:
[81-500]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
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I
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M
I
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C
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S
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C
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A
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L
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L
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L
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A
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I
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V
T
V
I
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L
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L
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L
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L
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C
G
K
L
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I
K
L
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L
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Y
C
F
A
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C
I
L
L
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N
M
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F
P
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L
Y
Y
L
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A
L
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K
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N
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L
G
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V
F
Y
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C
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D
L
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S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
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K
T
F
Y
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C
S
S
L
T
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V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
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C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
73
80.78
100%
-120.41
- C- -
M073
-
A:
[32-422]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
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I
I
N
I
P
D
S
-------------
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
------------
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
----------
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
69
80.73
100%
-137.79
- C- -
M069
-
A:
[81-500]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
61
80.67
100%
-138.33
- C- -
M061
-
A:
[81-477]
--------------------------------------------------------------------------------
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
-----------------------------
72
80.09
100%
-117.80
- C- -
M072
-
A:
[32-418]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
-------------
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
------------
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
------------
E
F
P
N
S
L
Y
Y
L
G
------------
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
74
79.81
100%
-121.70
- C- -
M074
-
A:
[32-418]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
-------------
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
------------
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
------------
E
F
P
N
S
L
Y
Y
L
G
------------
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
--------------------
54
78.85
100%
-109.86
- C- -
M054
-
A:
[32-421]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
------------
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
---------------------
56
78.70
100%
-106.79
- C- -
M056
-
A:
[32-421]
-------------------------------
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
------------
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
---------------------
59
78.34
100%
-117.50
- C- -
M059
-
A:
[31-519]
------------------------------
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
E
G
V
T
V
I
G
D
E
A
F
A
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
F
S
G
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
R
D
Y
C
F
A
E
C
I
L
L
E
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
64
75.26
100%
-112.54
- C- -
M064
-
A:
[31-519]
------------------------------
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
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L
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G
D
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N
S
S
L
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L
V
V
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I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
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I
G
Y
A
A
F
Q
G
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
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I
I
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I
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D
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M
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G
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C
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C
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A
L
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I
L
L
P
L
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L
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I
G
V
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A
F
K
G
C
D
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K
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I
T
I
P
E
G
V
T
V
I
G
D
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A
F
A
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C
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L
E
Y
V
S
L
P
D
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M
E
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L
H
N
G
L
F
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G
C
G
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L
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I
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R
N
L
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C
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A
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I
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L
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M
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N
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L
Y
Y
L
G
D
F
A
L
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T
G
V
K
N
I
I
I
P
D
S
F
T
E
L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
V
K
L
L
D
S
V
K
F
I
G
E
E
A
F
E
S
C
T
S
L
V
S
I
D
L
P
Y
L
V
E
E
I
G
K
R
S
F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
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L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
58
41.33
100%
-25.20
- C- -
M058
-
A:
[4-485]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
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G
L
R
E
F
L
N
L
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P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
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I
G
Y
A
A
F
Q
G
C
R
K
V
T
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I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
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I
I
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I
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D
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M
I
G
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C
T
F
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C
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A
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I
L
L
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L
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L
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I
G
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A
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K
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C
D
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T
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A
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A
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L
E
Y
V
S
L
P
D
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M
E
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L
H
N
G
L
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C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
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D
Y
C
F
A
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C
I
L
L
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M
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N
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L
Y
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L
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A
L
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K
N
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I
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P
D
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F
T
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L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
V
P
E
K
T
F
Y
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S
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L
T
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K
L
L
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K
F
I
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A
F
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C
T
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L
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S
I
D
L
P
Y
L
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I
G
K
R
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F
R
G
C
T
S
L
S
N
I
N
F
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L
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L
R
K
I
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A
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A
F
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G
C
I
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L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
70
40.38
100%
-33.85
- C- -
M070
-
A:
[4-547]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
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I
G
Y
A
A
F
Q
G
C
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K
V
T
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I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
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I
I
N
I
P
D
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K
M
I
G
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C
T
F
S
G
C
Y
A
L
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I
L
L
P
L
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L
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I
G
V
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A
F
K
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C
D
F
K
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I
T
I
P
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T
V
I
G
D
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A
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A
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C
E
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L
E
Y
V
S
L
P
D
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M
E
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L
H
N
G
L
F
S
G
C
G
K
L
K
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I
K
L
P
R
N
L
K
I
I
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D
Y
C
F
A
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I
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L
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M
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L
Y
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I
I
P
D
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F
T
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L
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
S
V
I
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P
E
K
T
F
Y
G
C
S
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L
T
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K
L
L
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F
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F
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C
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L
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S
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L
P
Y
L
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I
G
K
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F
R
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C
T
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L
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I
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L
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L
R
K
I
G
A
N
A
F
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G
C
I
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L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
57
38.98
100%
-24.03
- C- -
M057
-
A:
[4-478]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
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I
G
Y
A
A
F
Q
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C
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K
V
T
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I
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I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
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I
I
N
I
P
D
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V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
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I
T
I
P
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V
T
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A
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A
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L
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L
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M
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L
H
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G
L
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G
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L
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I
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N
L
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F
A
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I
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L
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M
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Y
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A
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I
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L
G
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V
F
Y
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C
T
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L
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I
S
I
Q
N
N
K
L
R
I
G
G
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L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
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V
I
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P
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T
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Y
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C
S
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L
T
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K
L
L
D
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V
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F
I
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A
F
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C
T
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L
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S
I
D
L
P
Y
L
V
E
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I
G
K
R
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F
R
G
C
T
S
L
S
N
I
N
F
P
L
S
L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
53
38.01
100%
-28.22
- C- -
M053
-
A:
[4-485]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
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K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
S
I
L
L
P
L
M
L
K
S
I
G
V
E
A
F
K
G
C
D
F
K
E
I
T
I
P
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V
T
V
I
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A
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A
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C
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S
L
E
Y
V
S
L
P
D
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M
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L
H
N
G
L
F
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G
C
G
K
L
K
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I
K
L
P
R
N
L
K
I
I
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D
Y
C
F
A
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C
I
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L
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M
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L
Y
Y
L
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D
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A
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I
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F
T
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L
G
K
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F
Y
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C
T
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L
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I
S
I
Q
N
N
K
L
R
I
G
G
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L
F
Y
N
C
S
G
L
K
K
V
I
Y
G
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I
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P
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Y
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C
S
S
L
T
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K
L
L
D
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V
K
F
I
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A
F
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C
T
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L
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S
I
D
L
P
Y
L
V
E
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I
G
K
R
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F
R
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C
T
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L
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N
I
N
F
P
L
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L
R
K
I
G
A
N
A
F
Q
G
C
I
N
L
K
K
V
E
L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
65
36.55
100%
-29.26
- C- -
M065
-
A:
[4-547]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
Q
G
C
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K
V
T
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I
K
I
P
S
T
V
R
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I
G
E
F
A
F
E
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C
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L
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I
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I
P
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K
M
I
G
R
C
T
F
S
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C
Y
A
L
K
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I
L
L
P
L
M
L
K
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I
G
V
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A
F
K
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C
D
F
K
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I
T
I
P
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V
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I
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A
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A
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C
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L
E
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V
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L
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M
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H
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L
F
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C
G
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L
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I
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L
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L
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I
I
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Y
C
F
A
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I
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L
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M
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Y
Y
L
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A
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T
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L
G
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F
Y
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C
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L
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I
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I
Q
N
N
K
L
R
I
G
G
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L
F
Y
N
C
S
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L
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K
V
I
Y
G
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V
I
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P
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Y
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C
S
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L
T
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K
L
L
D
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V
K
F
I
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A
F
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L
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S
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D
L
P
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L
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G
K
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C
T
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L
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I
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A
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A
F
Q
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C
I
N
L
K
K
V
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L
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K
55
36.41
100%
-20.54
- C- -
M055
-
A:
[4-478]
M
N
K
I
I
S
I
I
A
L
L
L
I
L
P
I
F
K
V
E
A
Y
D
F
V
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
L
R
E
F
L
N
L
E
P
G
D
R
N
S
S
L
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
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I
G
Y
A
A
F
Q
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C
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T
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I
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I
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I
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A
F
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C
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I
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M
I
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C
T
F
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C
Y
A
L
K
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I
L
L
P
L
M
L
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I
G
V
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A
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C
D
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I
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I
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A
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A
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L
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L
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L
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