@tome V2.1
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Global output mode :
Group entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Selected Ligands Contact
Catalytic Site Atlas
Show alignment :
Best alignments
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
Structural Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Modeller Score
Verify3D Model Score
QMean Model Score
Hide column
Complexes Prediction
Show Ligands of Templates
Comparative Docking Score
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Comparative Docking Tab
Atome Color :
Mutated
Helix
Strand
Conserved
Query sequence : >T0713: (2012-06-14 )
MKNLFKRIITTILVLTMVMGFNVPFSATTVMAASITYNVSSTIKGVLTDDGVLTISGTGAMPDYTKIANIPWYKDRDRISEVRVNSGITSIGEANFNSCYNMTKVTVASTVTSIGDGAFADTKLQSYTGMERVKKFGDYVFQGTDLDDFEFPGATTEIGNYIFYNSSVKRIVIPKSVTTIKDGIGYKAENLEKIEVSSNNKNYVAENYVLYNKNKTILESYPAAKTGTEFTIPSTVKTVTAYGFSYGKNLKKITITSGVTTLGDGAFYGMKALDEIAIPKNVTSIGSFLLQNCTALKTLNFYAKVKTVPYLLCSGCSNLTKVVMDNSAIETLEPRVFMDCVKLSSVTLPTALKTIQVYAFKNCKALSTISYPKSITLIESGAFEGSSITKYPTWLSKGNNGDYGIFTKIKYKGTDKYSEAYKVLKIVNKERKSKGLSELKMDKDLLDVAMQRAAEVALYFSHTRPDGSSCFSATDKMEAENIAGGQSSADAVMTSWMNSAGHRANILTSYFKTIGIGCFTQGGTVFWVQCFGTDTPATVSRPADKNVVVTVTVDGDFLSKTKLRLDSSSYNLKIGNKKTVKLYVQNPEWASQNVLLDNSNFTFKSYNTKKATISATGKINAKTVGKYKIKATLKNATGTSVTKSGKITFPQPKIKVTVKKKKAIVAWKKLKAAKGYYVYRREAKGKKYTKWKKVKNIKKNTTVKYKDSKLKKGKTYQYKVVAYNRKNKGTSAIKKIVIK
Atome Classification :
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKNLFKRIITTILVLTMVMGFNVPF-S-AT-TVMAASITYN-VSSTIKGVLTDDGVLTISGTGAMP-D-YTKIANIPWYKDRDRISEVRVN--SG-ITSIGEANFNSCYNMTKVTVAS-T-VTS--IGDGAFADT-KLQSYTGM-E-R-VKK--FG-DYVF-QGT-DLDDFEFPG-A-T-TEIG-N-YIF------------YN--S---SV----KRIVIP-K-S-VTTIKDGIGYK------A--ENL----EKIEVSSN-N-K---------------N-Y-V------------------A--------EN---------YVLY-NK--NK--------T------ILESYPAAKTG--T-EFTIP----------S--TVK--TVT--AYGFS---YG--KNLKKIT-------IT----------S---G-VTTLGDGAFYG----M--KAL----------D--EIAIP--K--N-VT--SIGSFLLQNCTALKTLNF-------Y-A-K-VKTVPYLLC------SGCSNL-TKVVMDNSAIE--TL--E--PRVFMDC--VKLSSV-TL-P-T-A-LKTIQVY---AFKNC--KALSTISY-PK--S-I-TLI-E--SGAF----EG------------SSI--TKYPTWLSK-G--NN---GDYGIF-----TKIKYKGTDKYS--EAYKV------LK-IVNKE--RKSKGLSELKMDK-D-LL--DVA-------M-QRAAEVALYFSHTR--------P--------------DGSSCFSATDKMEAENIAGGQSSAD--------AVMTSWMNSA------------GHRANILTS-Y-FKTIGIGCFTQGGTVFWVQCFG-T-DTPATVSRPAD-KN-VVVTVTVDG-DFLSKTKLRLDSSSYNLKIGNKKTVKL-YVQNPEWASQNVLLDNSNFTFKSYNTKKATISATGKINAKTVGKYKIKATLKNATGTSVTKSGKITFPQPKIKVTVKKKKAIVAWKKLKAAKGYYVYRREAKGKKYTKWKKVKNIKKNTTVKYKDSKLKKGKTYQYKVVAYNRKNKGTSAIKKIVIK
43
HHSearch
89.77
14%
-48.08
- C3 -
1ZIW
15
TLR3_HUMAN
A:
[9-605]
--------------------------------------
A
D
C
-
S
H
L
K
L
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P
D
D
L
--
P
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-
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A
A
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--
F
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-
N
E
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--
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F
A
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N
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E
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-
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-
I
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--
I
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-
N
N
P
F
-
V
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Q
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N
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L
D
L
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H
N
G
-
L
-
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-
L
-
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Q
------------
V
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--
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E--
N
L
----
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------
F
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----
K
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N
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I
-
K
---------------
E
-
F
-
S
------------------
P
--------
G
C
---------
F
H
A
I
-
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--
L
F
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L
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LNNVQ
L
G
P
S
L
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E
K
L
C
L
E
L
A
N
T
S
I
--
R
-
N
L
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L
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----------
N
S-
Q
L
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TT
S
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--
T
F
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G
L
---
K
W
--
T
N
L
T
M
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D
-------
L
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----------
Y
N--
N
-
L
N
V
V
G
N
D
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F
A
W
----
L
--
P
Q
L
----------
E
--
Y
F
F
L
E
--
Y
--
N
N
I
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--
H
L
F
S
H
S
L
H
G
L
F
N
V
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Y
L
N
L
KRSFTKQ------
L
P
K
I
D
D
F
S
F
------
Q
W
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C
L
-
E
H
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N
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--
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--
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--
S
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M
F
T
G
L
--
I
N
L
K
Y
L
-
S
L
-
S
-
N
-
S
-
F
T
S
L
R
T
L
TNE
T
F
V
S
L
AH
S
P
L
H
I
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N
L
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K
N
--
K
-
I
-
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I
-
E
--
S
D
A
F
----
S
W
------------
L
G
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--
L
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N
-
E
I
G
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---
L
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G
Q
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W
-----
R
G
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E
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I
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--
Y
N
K
Y
L
------
Q
L
-
T
R
N
S
F
--
A
L
V
P
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L
Q
R
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M
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R
R
-
V
A
L
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NV
D
S
S
-------
P
-
S
P
F
Q
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L
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N
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L
SNNNIA--
N
--------------
I
N
D
D
M
L
E
G
L
E
K
L
E
I
L
D
L
Q
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N
N
-
L
A
R
LWKHANPG
G
P
I
Y
F
L
K
G
L
S
------------
H
L
H
I
L
N
L
E
S
N
G
-
F
D
E
I
P
V
E
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F
K
D
L
F
E
L
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I
I
D
L
G
L
N
N
-
L
N
T
L
P
A
S
V
F
N
N
-
Q
V
-
S
L
K
S
L
N
L
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K
N
L
I
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V
E
K
K
V
F
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
86.46
11%
-43.02
- C3 -
1ZIW
15
TLR3_HUMAN
A:
[26-618]
----------------
N
I
T
V
L
N
L
T
H
-
N
Q
L
R
-
R
L
P
A
A
N
F
T
R
Y
-
S
Q
L
T
S
L
D
V
G
F
---------------
N
-
T
I
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K
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P
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L
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--
H
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A
F
C
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N
L
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E
L
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S
-
I
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--
I
K
N
N
P
F
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-
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G
-
L
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--
T
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I
-
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-
S
-
E
E
L
------------
D
I
--
F
AN
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----
K
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Q
-
I
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E
F
S
P
G
C
F
H
A
------
I
--
G
R
L
----
F
G
L
F
L
N
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-
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-
L
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S
L
T
E
K
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E
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ANT
S
-
I
-
R
------------------
N
--------
L
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---------
L
S
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S
-
Q
L
ST
T
S
--------
N
------
T
T
F
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L
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W
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N
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--
T
-
M
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----------
Y
N-
N
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--
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A
---
W
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--
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---
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----
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--
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RYLNLKRSFT
K
--
Q
-----------
L
P
--
K
I
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------
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--
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---
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--
G
Q
E
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----
R
G
------------
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---
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-----
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RV
A
L
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N
V
------
D
S
-
S
P
S
P
F
--
Q
P
L
R
N
L
T
I
L
D
L
S
N
N
N
-
I
A
--
N
I
N
-------
D
-
D
M
L
E
G
L
E
K
L
E
I
L
D
L
--------
Q
HNNLARLWKHANPG
G
P
I
Y
F
L
K
G
L
S
H
L
H
I
L
N
L
E
S
N
-
G
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--------
I
P
V
E
V
F
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D
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------------
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L
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N
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-
L
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A
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-
N
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------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
81.08
13%
-61.13
- C3 -
2ID5
7
LIGO1_HUMAN
A:
[1-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
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P
P
R
-
C
-
E
---------------
C
-
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--
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--------
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------
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S------
E
-
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Q
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--
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A
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--
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E
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-
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E
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-
C
-
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-
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E
---
A
L
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--
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G
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N
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A
I
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--
D
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----
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R
LYRLK
V
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E
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HW
P
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--
D
T
M
T
P
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C
L
Y
-
G
--
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N
---
L
T
S
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I
T
HCNL
T
A
V
P
Y
L
A
V
R
H
L
V
--
Y
L
R
F
L
N
LSYNP
I
S
-
T
I
E
G
S
ML
H
E
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R
L
Q
E
I
Q
L
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--
A
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EPYAFRG
L
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Q
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T
--------
T
--------------
L
E
E
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N
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A
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C
R
L
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WRLNFNRQQPTC
A
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----
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--------------------------------------------------------------------------------------------------------------------------
31
SP3
78.82
5%
-81.64
- C3 -
1XCD
5
PGS2_BOVIN
A:
[22-326]
-------------------
G
P
V
C
P
F
-
R
-
C
Q
C
H
L
R
V
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Q
C
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L
E
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V
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K
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P
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A
L
L
D
L
Q
N
------
N
-
K
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-
I
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A
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A
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--
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---
T
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-
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-
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--
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-
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T
-
N
---------------------------------
P
L
----
K
S
----------
S
G
I
E
N
G
A
F
Q
G
------
M
--
K
K
L
----
S
Y
I
R
I
A
D
T
-
N
-
I
---------------
T
-
T
-
I
------------------
P
--------
Q
G
---------
L
P
--------------------------------
P
S
L
--
T
-
E
L
H
L
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G---------
N
--
K
I
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--
K
V
D
--
A
A
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---
G
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--
N
N
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-------
L
S
----------
F
---
N
S
I
S
A
V
D
N
G
S
L
A
N
----
T
--
P
H
L
----------
R
--
E
L
H
L
N
--
N
--
N
K
L
V
--
K
V
P
G
G
-
L
A
D
H
K
Y
I
Q
V
V
Y
L
-------
H
N
N
-
N
-
I
S
A
I
G
S
N
D
F
CPPGYN
T
K
K
A
S
Y
-
S
G
V
S
L
F
S
N
P
V
Q
YW
E
I
--
Q
--
P
S
T
F
R
C
V
--
Y
V
R
A
A
V
-
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
77.32
12%
-37.05
- C3 -
3FXI
11
TLR4_HUMAN
A:
[29-552]
----------------
S
T
K
N
L
D
L
S
F
-
N
P
L
R
-
H
L
G
S
Y
S
F
F
S
F
-
P
E
L
Q
V
L
D
L
S
R
---------------
C
-
E
I
Q
T
I
E
D
G
A
Y
Q
S
L
S
H
L
S
T
L
I
L
T
--
G
N
P
I
Q
S
L
A
L
G
A
F
S
G
L
S
S
L
Q
K
L
V
A
V
E
-
T
N
L
A
S
--
L
E
N
F
P
I
G
H
L
K
T
L
K
E
L
N
V
A
-
H
-
N
L
I
Q
S
--
F
K
L
P
E
Y
F
-
S
N
L
T
N
L
E
H
L
D
L
S
S
N
K
-
I
-
Q
S
I
Y
-
C
-
T
D
L
------------
R
V
--
L
H
--
Q
M
PLLN
L
S
L
D
L
S
-
L
-
N
P
M
N
F
I
Q
P
G
A
F
K
E
------
I
---
R
L
----
H
K
L
T
L
R
N
N
-
F
-
D
---------------
S
-
L
-
N
V
M
K
T
C
I
Q
G
L
AGLEVH
R
L
V
L
--------
G
E
---------
F
R
N
E
G
N
L
--
E
K
--------
F
------
D
K
S
A
L
E
G
L
C
N
L
TI
E
-
E
F
R
L
A
----------
Y
LD
Y
Y
L
--
D
D
I
--
I
D
L
F
N
---
C
L
--
T
N
V
S
S
F
S
-------
L
V
----------
S
V--
T
-
I
E
R
V
K
D
F
-
S
Y
N
----
F
---
G
W
----------
Q
--
H
L
E
L
V
--
N
--
C
K
F
G
--
Q
F
P
T
---
L
K
L
K
S
L
K
R
L
T
F
-------
T
-
S
-
N
-
K
G
G
N
A
-
F
S
E
------
V
D
L
P
S
L
-
E
F
L
D
L
S
R
N
G
L
S
--
F
K
--
G
CC
S
Q
S
D
F
G
T
--
T
S
L
K
Y
L
-
D
L
-
S
-
F
-
N
G
V
I
T
M
S
S
N
----
F
L
G
L
--
E
Q
L
E
H
L
D
F
-
Q
H
--
S
N
L
-
K
Q
M
S
E
--
F
S
V
F
----
L
S
------------
L
R
N
--
L
I
Y
L
D
I
S
H
T
-
H
-----------------------------------
T
R
------
V
A
-
F
N
G
I
F
--
N
G
L
S
S
L
E
V
L
K
M
A
G
-
N
-
S
----
F
Q
-------
E
-----------------------
N
--------------
F
L
P
D
I
F
T
E
L
R
N
L
T
F
L
D
L
S
Q
C
-
Q
L
E
Q
--------
L
S
P
T
A
F
N
S
L
S
------------
S
L
Q
V
L
N
M
S
H
N
N
-
F
F
S
L
D
T
F
P
Y
K
C
L
N
S
L
Q
V
L
D
Y
S
L
-
N
H
I
M
T
S
K
K
Q
E
L
Q
H
-
F
P
S
S
L
A
F
L
N
L
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
76.42
13%
-61.75
- C3 -
1M0Z
-
GP1BA_HUMAN
A:
[1-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
P
-
I
---------------
C
-
E
-
V
------------------
S
--------
K
H
---------
L
E
V
N
-
C
D
--
K
R
--------
Q
------
L
T
A
L
P
P
D
L
P
K
D
--
T
-
T
I
L
H
L
----------
S
EN
L
L
Y
--
T
F
S
--
L
A
T
L
M
---
P
Y
--
T
R
L
T
Q
L
N
-------
L
D
R---------
C
---
E
-
L
T
K
L
Q
V
D
G
T
------
L
--
P
V
L
----------
G
--
T
L
D
L
S
--
H
--
N
-
Q
L
--
Q
S
L
P
L
L
G
Q
T
L
P
A
L
T
V
L
D
V
S------
F
-
N
-
R
-
L
T
S
L
P
L
G
A
L
------
R
G
L
G
E
L
-
Q
E
L
Y
L
K
G
N
E
L
K
--
T
L
--
P
--
P
G
L
L
T
P
T
--
P
K
L
E
K
L
-
S
L
-
A
N
N
-
Q
-
L
T
E
L
P
A
G
---
L
L
N
G
L
--
E
N
L
D
T
L
L
L
-
Q
E
N-
S
-
L
-
Y
T
I
-
P
--
K
G
F
F
----
G
S
------------
H
L
L
--
P
F
A
F
-------------------
L
-----
H
G
N
P
W
L
C
N
C
E
I
L
--
Y
F
R
R
W
------
L
Q
-
D
N
A
E
N
--
V
Y
V
W
K
Q
G
V
M
T
S
N
V
-
A
-
S
V
--
Q
C
D
-------
N
-
S
D
K
F
P
V
Y
K
Y
P
G
K
G
C
--------
P
--------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
76.08
12%
-29.64
- C3 -
3J0A
5
TLR5_HUMAN
A:
[35-534]
---------------------------------------------------------------------
Y
I
R
T
V
T
A
S
S
F
P
F
L
E
Q
L
Q
L
L
E
L
G
SQ
Y
T
-
P
L
T
I
D
K
E
A
F
R
N
L
P
N
L
R
I
L
D
L
G
S
-
S
K
I
Y
F
--
L
H
P
D
A
F
Q
G
L
F
H
L
F
E
L
R
L
Y
-
F
-
C
G
L
S
D
AV
L
K
-
D
G
Y
F
-
R
N
L
K
A
L
T
R
L
D
L
S
K
-
N
Q
I
-
R
S
L
Y
L
H
-
P
S
F
------------
G
K
--
L
N--
S
L
----
K
S
I
D
F
S
-
S
-
N
Q
I
F
L
V
C
E
H
E
L
E
P
L
Q
----
G
--
K
T
L
----
S
F
F
S
L
A
A
N
-
S
-
L
---------------
Y
-
S
R
V
------------------
S
--------
V
D
---------
W
G
K
C
------------------------
M
N
P
F
R
N
M
V
L
--
E
-
I
L
D
V
S
----------
G
N-
G
W
T
--
V
D
I
--
T
G
N
F
S
N
A
I
S
K
--
S
Q
A
F
S
L
I
-------
L
A
HHIMGAGFGF
H
---
N
-
I
K
D
P
D
Q
N
T
F
A
G
----
L
AR
S
S
V
----------
R
--
H
L
D
L
S
--
H
G-
F
-
V
F
--
S
L
N
S
R
V
F
E
T
L
K
D
L
K
V
L
N
L
-------
A
-
Y
-
N
K
I
N
K
I
A
D
E
A
F
------
Y
G
L
D
N
L
-
Q
V
L
N
L
S
Y
N
L
L
G
--
E
L
--
Y
--
S
S
N
F
Y
G
L
--
P
K
V
A
Y
I
-
D
L
-
Q
-
K
N
H
-
I
A
I
I
Q
D
Q
---
T
F
K
F
L
--
E
K
L
Q
T
L
D
L
-
R
D
--
N
A
L
-
T
T
I
-
H
-----------
F
------------
I
P
S
--
I
P
D
I
F
L
S
G
N
-
K
L-
V
T
---
L
P
K
---------
I
N
L
T
A
N
L
I
H
L
S
--
E
N
R
L
E
------
N
L
D
I
L
Y
F
L
--
L
R
V
P
H
L
Q
I
L
I
L
N
Q
-
N
R
F
S
--
S
C
S
-------
G
D
Q
T
P
S
E
N
P
S
L
E
Q
L
F
L
--------
G
E
N
M
L
QLAWETE---
L
C
W
D
V
F
E
G
L
S
H
L
Q
V
L
Y
L
N
H
N
-
Y
L
N
S
--------
L
P
P
G
V
F
S
H
L
T
------------
A
L
R
G
L
S
L
N
S
-
N
R
L
T
V
L
S
H
N
D
L
P
--
A
N
L
E
I
L
D
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
74.65
17%
-66.68
- C3 -
1XKU
3
PGS2_BOVIN
A:
[22-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
C
P
F
-
R
-
C
-
Q
C
H
L
-
R
-
V
V
Q
C
S
DLGLEKVPKD
L
P
--
P
---
D
T
----
A
L
L
D
L
Q
-
N
N
K
-
I
T
E
I
K
D
G
D
F
K
N
------
L
--
K
N
L
----
H
T
L
I
L
I
N
N
-
K
-
I
---------------
S
-
K
-
I
------------------
S
--------
P
G
AFAPLVKLE
R
L
Y
L
-
S
K
--
N
Q
--------
L
------
K
E
L
P
E
K
M
P
K
T
L
--
Q
-
E
L
R
V
H
----------
E
N-
E
I
T
--
K
V
R
--
K
S
V
F
N
---
G
L
--
N
Q
M
I
V
V
E
-------
L
G
----------
T
NPL
K
-
S
S
G
I
E
N
G
A
F
Q
G
----
M
--
K
K
L
----------
S
--
Y
I
R
I
A
--
D
--
T
N
I
T
--
T
I
P
Q
G
L
P
P
S
L
T
E
L
H
L
D
G
----------
N
-
K
-
I
T
K
V
D
A
A
S
L
------
K
G
L
N
N
L
-
A
K
L
G
L
S
F
N
S
I
S
--
A
V
--
D
--
N
G
S
L
A
N
T
--
P
H
L
R
E
L
-
H
L
-
N
-
N
-
N
-
K
L
V
K
V
P
G
---
G
L
A
D
H
--
K
Y
I
Q
V
V
Y
L
-
H
N
N-
N
-
I
-
S
A
I
-
G
--
S
N
D
F
CPPG
Y
N
------------
T
K
K
--
A
S
Y
S
G
V
S
L
F
-
S
--
N
P
---
V
Q
Y
W
E
I
-----
Q
P
S
T
F
R
C
V
Y
V
R
A
--
A
V
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
73.58
18%
-102.68
- C3 -
2ID5
6
LIGO1_HUMAN
A:
[23-327]
----------------------------------------------------------------------
F
V
A
V
P
E
G
I
P
---
T
E
T
R
L
L
D
L
G
--
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
-
N
I
V
S
A
--
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
-
S
N
R
-
L
K
L
--
I
P
-
L
G
V
F
-
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
-
I
-
V
I
L
L
-
D
-
Y
M
F
------------
Q
D
--
L
Y--
N
L
----
K
S
L
E
V
G
-
D
-
N
D
L
V
Y
I
S
H
R
A
F
S
G
------
L
--
N
S
L
----
E
Q
L
T
L
E
K
C
-
N
------------------------------------------------------------------------------------------------------------------------
L
T
--
S
I
P
--
T
E
A
L
S
---
H
L
--
H
G
L
I
V
L
R
-------
L
R
----------
H
L--
N
-
I
N
A
I
R
D
Y
S
F
K
R
----
L
--
Y
R
L
----------
K
--
V
L
E
I
S
--
H
WP
Y
-
L
D
--
T
M
T
P
N
C
L
Y
G
-
L
N
L
T
S
L
S
I
-------
T
-
H
C
N
-
L
T
A
V
P
Y
L
A
V
------
R
H
L
V
Y
L
-
R
F
L
N
L
S
Y
N
P
I
S
--
T
I
--
E
--
G
S
M
L
H
E
L
--
L
R
L
Q
E
I
-
Q
L
-
V
-
G
-
G
Q
L
A
V
V
E
P
Y
---
A
F
R
G
L
--
N
Y
L
R
V
L
N
V
-
S
G
--
N
Q
L
-
T
T
L
-
E
--
E
S
V
F
----
H
S
------------
V
G
N
--
L
E
T
L
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
73.28
14%
-45.79
- C3 -
3J0A
4
TLR5_HUMAN
A:
[26-390]
-----------------
T
E
R
L
L
L
S
F
N
Y
-
I
R
-
T
V
T
A
S
S
F
P
F
L
-
E
Q
L
Q
L
L
E
L
G
S
-------------
Q
-
Y
-
T
P
L
T
I
D
K
E
A
F
R
N
L
P
N
L
R
I
L
D
L
G
--
S
S
K
I
Y
F
L
H
P
D
A
F
Q
G
L
F
H
L
F
E
L
R
L
Y
F
-
C
G
L
S
D
AV
L
K
D
G
Y
F
R
N
L
K
A
L
T
R
L
D
L
S
-
K
-
N
Q
I
R
S
--
L
Y
L
H
P
S
F
-
G
K
L
N
S
L
K
S
I
D
F
S
S
N
Q
-
I
-
F
L
V
C
-
E
-
H
E
L
------------
E
P
L
Q
G
K
--
T
L
----
S
F
F
S
L
A
-
A
-
N
S
L
Y
S
R
V
S
V
D
W
G
K
CMNPFR
N
--
M
V
L
----
E
I
L
D
V
S
G
N
-
G
-
W
---------------
T
V
D
-
I
------------------
T
--------
G
N
---------
F
---------------------------
S
N
A
I
S
K
S
Q
A
--
F
-
S
L
I
L
A
HHIMGAGFGF
H
--
N
I
K
--
D
P
D
--
Q
N
T
F
A
---
G
L
AR
S
S
V
R
H
L
D
-------
L
S
----------
H
G--
F
-
V
F
S
L
N
S
R
V
F
E
T
----
L
--
K
D
L
----------
K
--
V
L
N
L
A
--
Y
N
-
K
-
I
N
--
K
I
A
D
E
A
F
Y
G
L
D
N
L
Q
V
L
N
L
-------
S
-
Y
-
N
L
L
G
E
L
Y
S
S
N
F
------
Y
G
L
P
K
V
-
A
Y
I
D
L
Q
K
N
H
I
A
--
I
I
--
Q
--
D
Q
T
F
K
F
L
--
E
K
L
Q
T
L
-
D
L
-
R
-
D
-
N
A
L
T
T
I
H
F
--------
I
--
P
S
I
P
D
I
F
L
-
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
73.28
10%
-23.55
* C3 *
3FXI
11
TLR4_HUMAN
A:
[8-542]
----------------------------------
P
N
I
T
Y
Q
C
-
M
E
L
N
F
Y
K
I
P
D
N
--
L
P
F
S
T
K
N
L
D
L
S
F
N
-
P
L
R
H
L
G
S
Y
S
F
F
S
F
P
E
L
Q
V
L
D
L
S
--
R
C
E
I
Q
T
I
E
D
G
A
Y
Q
S
L
S
H
L
S
T
L
I
L
T
G
-
N
P
I
Q
S
--
L
A
L
G
A
F
S
G
L
S
S
L
Q
K
L
V
A
V
-
E
T
N
-
L
A
S
--
L
E
-
N
F
P
I
-
G
H
L
K
T
L
K
E
L
N
V
A
H
-
N
L
I
-
Q
S
F
K
L
P
-
E
Y
F
------------
S
N
--
L
T--
N
L
----
E
H
L
D
L
S
-
S
-
N
K
I
Q
S
I
Y
C
T
D
L
R
V
------
L
--
H
Q
M
PLLN
L
S
L
D
L
S
L
N
-
P
M
N
---------------
F
-
I
-
Q
------------------
P
--------
G
---------------------------------------
A
F
K
E
I
-
R
L
--
H
-
K
L
T
L
R
----------
N
--
N
F
D
--
S
L
N
V
M
K
T
C
I
Q
---
G
L
--
A
G
L
E
V
H
R
L
V
L
G
E
F
R
N
E
----------
G
---
N
-
L
E
K
F
D
K
S
A
L
E
G
----
L
--
C
N
L
----------
T
IE
E
F
R
L
A
Y
L
D
--
Y
-
Y
L
--
D
D
I
I
D
L
F
N
C
L
T
N
V
S
S
F
S
L
-------
V
-
S
-
V
T
I
E
R
V
K
D
F
-
S
------
Y
N
F
-
G
W
-
Q
H
L
E
L
V
N
C
K
F
G
--
Q
F
--
P
--
T
L
---
K
L
--
K
S
L
K
R
L
-
T
F
-
T
-
S
-
N
-
K
G
G
N
A
F
S
---
E
-
V
D
L
--
P
S
L
E
F
L
D
L
-
S
R
--
N
G
L
-
S
F
K
-
G
CC
S
Q
S
D
----
F
G
------------
T
T
S
--
L
K
Y
L
D
L
S
F
N
-
G
V
-
I
T
---
M
S
S
N
-
F
-----
L
G
L
E
Q
L
E
H
L
D
F
Q
--
H
S
N
L
K
------
Q
M
S
E
F
S
V
F
--
L
S
L
R
N
L
I
Y
L
D
I
S
H
-
T
H
T
R
--
V
A
F
-------
N
-
G
I
F
----------------------------------------
N
G
L
S
S
L
E
V
L
K
M
A
G
N
S
F
Q
E
N
--------
F
L
P
D
I
F
T
E
L
R
------------
N
L
T
F
L
D
L
S
Q
C
Q
-
L
E
Q
L
S
P
T
A
F
N
S
L
S
S
L
Q
V
L
N
M
S
H
-
N
N
F
F
S
L
D
T
F
P
Y
K
C
-
L
N
-
S
L
Q
V
L
D
Y
S
L
N
H
I
M
T
S
K
K
Q
E
L
Q
H
F
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
SP3
70.86
7%
-76.17
- C3 -
1O6S
4
INLA_LISMO
A:
[6-465]
---------
A
T
I
T
Q
D
T
P
I
--
N
Q
I
F
T
-
D
-
T
A
-
L
A
E
K
M
K
T
V
L
G
-
K
T
N
V
T
D
T
V
S
Q
T
D
L
D
-
Q
V
T
T
L
Q
A
D
R
-
L
-
G
I
K
S
I
D
G
--
V
E
Y
L
N
N
L
T
Q
I
N
F
S
N-
N
Q
-
L
T
D
I
--
T
P
L
K
N
L
T
K
L
V
D
I
L
M
N
N
-
N
Q
I
A
D
--
I
T
P
-
L
A
N
L
T
-
N
L
T
G
L
T
L
F
N
N
-
Q
-
I
T
D
--
I
D
--
P
L
K
-
N
L
T
-
N
L
N
R
L
E
L
S
S
-
N
-
T
-
I
S
D
I
-
S
-
A
L
S
------------
G
L
--
T
---
S
L
----
Q
Q
L
S
F
G
-
N
-
Q
-
V
T
D
L
K
P
--
L
A
N
------
L
--
T
T
L
----
E
R
L
D
I
S
S
N
-
K
-
V
---------------
S
-
D
-
I
------------------
S
V
L
A
K
LTNL
E
S
---------
L
I
A
T
-
N
N
--
Q
I
--------
S
------
D
I
T
P
L
G
I
L
T
N
L
--
D
-
E
L
S
L
N
G---------
N
--
Q
L
K
--
D
I
G
--
T
--
L
A
---
S
L
--
T
N
L
T
D
L
D
-------
L
A
----------
N
---
N
Q
I
S
N
L
--
A
P
L
S
G
----
L
--
T
K
L
----------
T
--
E
L
K
L
G
--
A
--
N
Q
I
S
--
N
I
--
S
P
L
A
G
L
T
A
L
T
N
L
E
L
-------
N
E
N
-
Q
-
L
E
D
I
--
S
P
I
------
S
N
L
K
N
L
-
T
Y
L
T
L
Y
F
N
N
I
S
--
D
I
------
S
P
V
S
S
L
--
T
K
L
Q
R
L
-
F
F
-
Y
-
N
-
N
K
V
S
D
V
--
S
---
S
L
A
N
L
--
T
N
I
N
W
L
S
A
-
G
H
--
N
Q
I
-
S
D
L
-
T
--
P
--
L
----
A
N
------------
L
T
R
--
I
T
Q
L
G
L
N
D
Q
-
A
--
W
T
N
A
P
V
N
Y
K
A
N
-----
V
S
I
P
N
T
V
K
N
V
T
G
--
A
L
I
A
P
------
A
T
-
I
S
D
G
G
--
S
Y
T
E
P
D
I
T
W
N
L
P
S
-
Y
-
T
N
--
E
V
--------
S
-
Y
T
F
S
Q
P
V
T
I
G
K
G
T
T
T
F
S
G
T
V
T
Q
P
--------------
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
SP3
69.74
4%
-71.86
- C3 -
1OZN
5
RTN4R_HUMAN
A:
[1-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
C
P
-
G
A
C
V
C
Y
N
E
-
P
K
V
T
T
S
C
P
Q
-
Q
G
L
-
Q
A
V
P
-
V
-
G
I
P
------------
A
-------
A
S
----
Q
R
I
F
L
H
G
N
-
R
-
I
S
H
V
P
A
A
S
F
R
A
------
C
--
R
N
L
----
T
I
L
W
L
H
S
N
-
V
-
L
---------------
A
-
R
-
I
------------------
D
--------
A
A
---------
A
F
T
-----------------------------
G
L
A
L
L
--
E
-
Q
L
D
L
S
----------
D
NA
Q
L
R
--
S
V
D
--
P
A
T
F
H
---
G
L
--
G
R
L
H
T
L
H
-------
L
D
----------
R
---
C
G
L
Q
E
L
G
P
G
L
F
R
G
----
L
--
A
A
L
----------
Q
--
Y
L
Y
L
Q
--
D
--
N
A
L
Q
--
A
L
P
D
D
T
F
R
D
L
G
N
L
T
H
L
F
L
-------
H
G
N
-
R
-
I
S
S
V
P
E
R
A
F
------
R
G
L
H
S
L
-
D
R
L
L
L
H
Q
N
R
V
A
--
H
V
--
H
--
P
H
A
F
R
D
L
--
G
R
L
M
T
L
-
Y
L
-
F
-
A
-
N
N
L
S
A
L
P
T
E
---
A
L
A
P
L
--
R
A
L
Q
Y
L
R
L
-
N
D
--
N
-
P
-
W
V
C
-
D
--
C
R
A
R
----
P
L
------------
W
A
W
--
L
Q
K
F
R
G
S
S
S
-
E
--
V
P
---
C
S
L
P
Q
R
-----
L
A
G
R
D
L
K
R
L
A
A
N
--
D
L
Q
G
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
64.70
11%
-31.19
- C3 -
2Z64
4
TLR4_MOUSE
A:
[4-185]
-------------------------------
E
V
V
P
N
I
T
Y
Q
C
-
M
D
Q
K
L
S
K
V
P
D
D
I
P
--
S
S
T
K
N
I
D
L
S
-
F
N
P
L
K
I
L
K
S
Y
S
F
S
N
F
S
E
L
Q
W
L
D
L
S
--
R
C
E
I
E
T
I
E
D
K
A
W
H
G
L
H
H
L
S
N
L
I
L
T
G
-
N
P
I
Q
S
--
F
S
P
G
S
F
S
G
L
T
S
L
E
N
L
V
A
V
-
E
T
K
-
L
A
S
--
L
E
-
S
F
P
I
-
G
Q
L
I
T
L
K
K
L
N
V
A
H
-
N
F
I
-
H
S
C
K
L
P
-
A
Y
F
------------
S
N
--
L
T--
N
L
----
V
H
V
D
L
S
-
Y
-
N
Y
I
Q
T
I
T
V
N
D
L
Q
F
------
L
--
R
E
N
PQ
V
N
L
S
L
D
M
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
64.12
20%
-10.02
- C3 -
3SB4
7
?
A:
[102-326]
----------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
V
I
L
S
-
E
-
K
-
I
K
N
--
I
E
-
D
A
A
F
-
K
G
C
D
N
L
K
I
C
Q
I
R
K
-
K
T
A
-
P
N
L
L
-
P
-
E
A
L
------------
A
D
------
S
V
----
T
A
I
F
I
P
-
L
-
G
-----
S
S
D
A
Y
R
F
------
K
--
N
R
W
----
E
H
F
A
F
I
E
G
-
E
-----------------------------------------------------------------------------------------------
P
L
--
E
T
T
I
Q
V
-----------
G
--
A
M
G
--
K
L
E
--
D
E
I
M
K
---
A
G
--
L
Q
P
R
D
I
N
-------
F
L
----------
T
---
I
-
E
G
K
L
D
N
A
D
F
K
L
I
R
D
Y
M
--
P
N
L
----------
V
--
S
L
D
I
S
--
K
T-
N
-
A
T
--
T
I
P
D
F
T
F
A
Q
K
K
Y
L
L
K
I
K
L
-------
P
-
H
-
N
-
L
K
T
I
G
Q
R
V
F
------
S
N
C
G
R
L
A
G
T
L
E
L
P
A
-
S
V
T
--
A
I
--
E
--
F
G
A
F
M
G
C
--
D
N
L
R
Y
V
-
L
A
T
G
-
D
-
K
-
I
T
T
L
G
D
E
---
L
F
G
N
G
--
V
P
S
K
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
62.10
13%
-29.22
- C3 -
3RGZ
5
BRI1_ARATH
A:
[220-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
C
S
A
L
--
Q
-
H
L
D
I
S
----------
G
N-
K
L
S
--
G
D
F
--
S
R
A
I
S
---
T
C
--
T
E
L
K
L
L
N
-------
I
S
----------
S
---
N
Q
F
V
G
P
I
P
--
P
L
P
----
L
--
K
S
L
----------
Q
--
Y
L
S
L
A
--
E
--
N
-
K
F
T
G
E
I
P
D
F
L
S
G
A
C
D
T
L
T
G
L
D
L
-------
S
-
G
-
N
H
F
Y
G
A
V
P
P
F
F
------
G
S
C
S
L
L
-
E
S
L
A
L
S
S
N
N
F
S
G-
E
L
--
P
--
M
D
T
L
L
K
M
--
R
G
L
K
V
L
-
D
L
-
S
-
F
-
N
E
F
S
G
E
L
P
E
---
S
L
T
N
L
S-
A
S
L
L
T
L
D
L
-
S
S
--
N
-
N
F
S
G
P
-
I
--
L
P
N
L
----
C
Q
------------
N
P
K
NT
L
Q
E
L
Y
L
Q
N
N
-
G
--
F
T
G--
K
I
P
P
T
L
-----
S
N
C
S
E
L
V
S
L
H
L
S
--
F
N
Y
L
S
------
G
T
-
I
P
S
S
L
--
G
S
L
S
K
L
R
D
L
K
L
W
L
-
N
M
L
E
--
G
E
I
-------
P
-
Q
E
L
M
Y
V
K
T
L
E
T
L
I
L
--------
D
FND
L
T
G
--------
E
I
P
S
G
L
S
N
C
T
N
L
N
W
I
S
L
S
N
N
-
R
L
T
G
--------
E
I
P
K
W
I
G
R
L
E
------------
N
L
A
I
L
K
L
S
N
-
N
S
F
S
G
N
I
P
A
E
L
G
D
C
R
S
L
I
W
L
D
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
61.13
9%
-33.22
- C3 -
2Z63
-
TLR4_HUMAN
A:
[6-175]
--------------------------------
V
V
P
N
I
T
Y
Q
C
-
M
E
L
N
F
Y
K
I
P
D
N
L
--
P
F
S
T
K
N
L
D
L
S
F
N
-
P
L
R
H
L
G
S
Y
S
F
F
S
F
P
E
L
Q
V
L
D
L
S
--
R
C
E
I
Q
T
I
E
D
G
A
Y
Q
S
L
S
H
L
S
T
L
I
L
T
G
-
N
P
I
Q
S
--
L
A
L
G
A
F
S
G
L
S
S
L
Q
K
L
V
A
V
-
E
T
N
-
L
A
S
--
L
E
-
N
F
P
I
-
G
H
L
K
T
L
K
E
L
N
V
A
H
-
N
-
L
I
Q
S
F
K
L
P
-
E
Y
F
------------
S
N
--
L
T--
N
L
----
E
H
L
D
L
S
-
S
N
K
-
I
Q
S
I
Y
C
T
D
L
R
V
------
L
--
H
Q
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
57.92
10%
-22.52
- C3 -
2Z64
3
TLR4_MOUSE
A:
[28-207]
----------------
S
T
K
N
I
D
L
S
F
-
N
P
L
K
-
I
L
K
S
Y
S
F
S
N
F
-
S
E
L
Q
W
L
D
L
S
R
---------------
C
-
E
I
E
T
I
E
D
K
A
W
H
G
L
H
H
L
S
N
L
I
L
T
--
G
N
P
I
Q
S
F
S
P
G
S
F
S
G
L
T
S
L
E
N
L
V
A
V
E
-
T
K
L
A
S
--
L
E
S
F
P
I
G
Q
L
I
T
L
K
K
L
N
V
A
-
H
-
N
F
I
H
S
--
C
K
L
P
A
Y
F
-
S
N
L
T
N
L
V
H
V
D
L
S
Y
N
Y
-
I
-
Q
T
I
T
-
V
-
N
D
L
------------
Q
F
--
L
R
--
E
N
PQ
V
N
L
S
L
D
M
S
-
L
-
N
P
I
D
F
I
Q
D
Q
A
F
Q
G
------
I
--
K
-
L
----
H
E
L
T
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
57.64
12%
-46.54
- C3 -
3T6Q
5
CD180_MOUSE
A:
[34-138]
-----------------------------------------------------------------------------------
S
T
E
C
L
E
F
S
--
F
N
V
L
P
T
I
Q
N
T
T
F
S
R
L
I
N
L
T
F
L
D
L
T
R
C
Q
-
I
Y
W
--
I
H
E
D
T
F
Q
S
Q
H
R
L
D
T
L
V
L
T
-
A
-
N
P
L
I
F
--
M
A
-
E
T
A
L
-
S
G
P
K
A
L
K
H
L
F
F
I
Q
T
G
-
I
-
S
S
I
D
-
F
-
I
P
L
------------
H
N
--
Q
K--
T
L
----
E
S
L
Y
L
G
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
56.94
7%
-33.93
- C3 -
3T6Q
6
CD180_MOUSE
A:
[15-184]
------------------------------------
K
T
Y
N
C
-
E
N
L
G
L
N
E
I
P
G
T
L
P
--
N
S
T
E
C
L
E
F
S
F
N
-
V
L
P
T
I
Q
N
T
T
F
S
R
L
I
N
L
T
F
L
D
L
T
--
R
C
Q
I
Y
W
I
H
E
D
T
F
Q
S
Q
H
R
L
D
T
L
V
L
T
A
-
N
P
L
I
F
--
M
A
E
T
A
L
S
G
P
K
A
L
K
H
L
F
F
I
-
Q
T
G
-
I
S
S
--
I
D
-
F
I
P
L
-
H
N
Q
K
T
L
E
S
L
Y
L
G
S
-
N
H
I
-
S
S
I
K
-
L
P
K
G
F
------------
P
---
T
E--
K
L
----
K
V
L
D
F
Q
-
N
-
N
A
I
H
Y
L
S
K
E
D
M
S
S
------
L
--
Q
Q
A
----
T
N
L
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
User Run . : Multi Template Modeling Result:
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKNLFKRIITTILVLTMVMGFNVPFSATTVMAASITYNVSSTIKGVLTDDGVLTISGTGAMPDYTKIANIPWYKDRDRISEVRVNSGITSIGEANFNSCYNMTKVTVASTVTSIGDGAFADTKLQSYTGMERVKKFGDYVFQGTDLDDFEFPGATTEIGNYIFYNSSVKRIVIPKSVTTIKDGIGYKAENLEKIEVSSNNKNYVAENYVLYNKNKTILESYPAAKTGTEFTIPSTVKTVTAYGFSYGKNLKKITITSGVTTLGDGAFYGMKALDEIAIPKNVTSIGSFLLQNCTALKTLNFYAKVKTVPYLLCSGCSNLTKVVMDNSAIETLEPRVFMDCVKLSSVTLPTALKTIQVYAFKNCKALSTISYPKSITLIESGAFEGSSITKYPTWLSKGNNGDYGIFTKIKYKGTDKYSEAYKVLKIVNKERKSKGLSELKMDKDLLDVAMQRAAEVALYFSHTRPDGSSCFSATDKMEAENIAGGQSSADAVMTSWMNSAGHRANILTSYFKTIGIGCFTQGGTVFWVQCFGTDTPATVSRPADKNVVVTVTVDGDFLSKTKLRLDSSSYNLKIGNKKTVKLYVQNPEWASQNVLLDNSNFTFKSYNTKKATISATGKINAKTVGKYKIKATLKNATGTSVTKSGKITFPQPKIKVTVKKKKAIVAWKKLKAAKGYYVYRREAKGKKYTKWKKVKNIKKNTTVKYKDSKLKKGKTYQYKVVAYNRKNKGTSAIKKIVIK
69
97.67
100%
-75.96
- C- -
M069
-
A:
[10-516]
---------
T
T
I
L
V
L
T
M
V
M
G
F
N
V
P
F
S
A
T
T
V
M
A
A
S
I
T
Y
N
V
S
S
T
I
K
G
V
L
T
D
D
G
V
L
T
I
S
G
T
G
A
M
P
D
Y
T
K
I
A
N
I
P
W
Y
K
D
R
D
R
I
S
E
V
R
V
N
S
G
I
T
S
I
G
E
A
N
F
N
S
C
Y
N
M
T
K
V
T
V
A
S
T
V
T
S
I
G
D
G
A
F
A
D
T
K
L
Q
S
Y
T
G
M
E
R
V
K
K
F
G
D
Y
V
F
Q
G
T
D
L
D
D
F
E
F
P
G
A
T
T
E
I
G
N
Y
I
F
Y
N
S
S
V
K
R
I
V
I
P
K
S
V
T
T
I
K
D
G
I
G
Y
K
A
E
N
L
E
K
I
E
V
S
S
N
N
K
N
Y
V
A
E
N
Y
V
L
Y
N
K
N
K
T
I
L
E
S
Y
P
A
A
K
T
G
T
E
F
T
I
P
S
T
V
K
T
V
T
A
Y
G
F
S
Y
G
K
N
L
K
K
I
T
I
T
S
G
V
T
T
L
G
D
G
A
F
Y
G
M
K
A
L
D
E
I
A
I
P
K
N
V
T
S
I
G
S
F
L
L
Q
N
C
T
A
L
K
T
L
N
F
Y
A
K
V
K
T
V
P
Y
L
L
C
S
G
C
S
N
L
T
K
V
V
M
D
N
S
A
I
E
T
L
E
P
R
V
F
M
D
C
V
K
L
S
S
V
T
L
P
T
A
L
K
T
I
Q
V
Y
A
F
K
N
C
K
A
L
S
T
I
S
Y
P
K
S
I
T
L
I
E
S
G
A
F
E
G
S
S
I
T
K
Y
P
T
W
L
S
K
G
N
N
G
D
Y
G
I
F
T
K
I
K
Y
K
G
T
D
K
Y
S
E
A
Y
K
V
L
K
I
V
N
K
E
R
K
S
K
G
L
S
E
L
K
M
D
K
D
L
L
D
V
A
M
Q
R
A
A
E
V
A
L
Y
F
S
H
T
R
P
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
97.64
100%
-57.09
- C- -
M073
-
A:
[10-640]
---------
T
T
I
L
V
L
T
M
V
M
G
F
N
V
P
F
S
A
T
T
V
M
A
A
S
I
T
Y
N
V
S
S
T
I
K
G
V
L
T
D
D
G
V
L
T
I
S
G
T
G
A
M
P
D
Y
T
K
I
A
N
I
P
W
Y
K
D
R
D
R
I
S
E
V
R
V
N
S
G
I
T
S
I
G
E
A
N
F
N
S
C
Y
N
M
T
K
V
T
V
A
S
T
V
T
S
I
G
D
G
A
F
A
D
T
K
L
Q
S
Y
T
G
M
E
R
V
K
K
F
G
D
Y
V
F
Q
G
T
D
L
D
D
F
E
F
P
G
A
T
T
E
I
G
N
Y
I
F
Y
N
S
S
V
K
R
I
V
I
P
K
S
V
T
T
I
K
D
G
I
G
Y
K
A
E
N
L
E
K
I
E
V
S
S
N
N
K
N
Y
V
A
E
N
Y
V
L
Y
N
K
N
K
T
I
L
E
S
Y
P
A
A
K
T
G
T
E
F
T
I
P
S
T
V
K
T
V
T
A
Y
G
F
S
Y
G
K
N
L
K
K
I
T
I
T
S
G
V
T
T
L
G
D
G
A
F
Y
G
M
K
A
L
D
E
I
A
I
P
K
N
V
T
S
I
G
S
F
L
L
Q
N
C
T
A
L
K
T
L
N
F
Y
A
K
V
K
T
V
P
Y
L
L
C
S
G
C
S
N
L
T
K
V
V
M
D
N
S
A
I
E
T
L
E
P
R
V
F
M
D
C
V
K
L
S
S
V
T
L
P
T
A
L
K
T
I
Q
V
Y
A
F
K
N
C
K
A
L
S
T
I
S
Y
P
K
S
I
T
L
I
E
S
G
A
F
E
G
S
S
I
T
K
Y
P
T
W
L
S
K
G
N
N
G
D
Y
G
I
F
T
K
I
K
Y
K
G
T
D
K
Y
S
E
A
Y
K
V
L
K
I
V
N
K
E
R
K
S
K
G
L
S
E
L
K
M
D
K
D
L
L
D
V
A
M
Q
R
A
A
E
V
A
L
Y
F
S
H
T
R
P
D
G
S
S
C
F
S
A
T
D
K
M
E
A
E
N
I
A
G
G
Q
S
S
A
D
A
V
M
T
S
W
M
N
S
A
G
H
R
A
N
I
L
T
S
Y
F
K
T
I
G
I
G
C
F
T
Q
G
G
T
V
F
W
V
Q
C
F
G
T
D
T
P
A
T
V
S
R
P
A
D
K
N
V
V
V
T
V
T
V
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
97.21
100%
-76.41
- C- -
M067
-
A:
[10-521]
---------
T
T
I
L
V
L
T
M
V
M
G
F
N
V
P
F
S
A
T
T
V
M
A
A
S
I
T
Y
N
V
S
S
T
I
K
G
V
L
T
D
D
G
V
L
T
I
S
G
T
G
A
M
P
D
Y
T
K
I
A
N
I
P
W
Y
K
D
R
D
R
I
S
E
V
R
V
N
S
G
I
T
S
I
G
E
A
N
F
N
S
C
Y
N
M
T
K
V
T
V
A
S
T
V
T
S
I
G
D
G
A
F
A
D
T
K
L
Q
S
Y
T
G
M
E
R
V
K
K
F
G
D
Y
V
F
Q
G
T
D
L
D
D
F
E
F
P
G
A
T
T
E
I
G
N
Y
I
F
Y
N
S
S
V
K
R
I
V
I
P
K
S
V
T
T
I
K
D
G
I
G
Y
K
A
E
N
L
E
K
I
E
V
S
S
N
N
K
N
Y
V
A
E
N
Y
V
L
Y
N
K
N
K
T
I
L
E
S
Y
P
A
A
K
T
G
T
E
F
T
I
P
S
T
V
K
T
V
T
A
Y
G
F
S
Y
G
K
N
L
K
K
I
T
I
T
S
G
V
T
T
L
G
D
G
A
F
Y
G
M
K
A
L
D
E
I
A
I
P
K
N
V
T
S
I
G
S
F
L
L
Q
N
C
T
A
L
K
T
L
N
F
Y
A
K
V
K
T
V
P
Y
L
L
C
S
G
C
S
N
L
T
K
V
V
M
D
N
S
A
I
E
T
L
E
P
R
V
F
M
D
C
V
K
L
S
S
V
T
L
P
T
A
L
K
T
I
Q
V
Y
A
F
K
N
C
K
A
L
S
T
I
S
Y
P
K
S
I
T
L
I
E
S
G
A
F
E
G
S
S
I
T
K
Y
P
T
W
L
S
K
G
N
N
G
D
Y
G
I
F
T
K
I
K
Y
K
G
T
D
K
Y
S
E
A
Y
K
V
L
K
I
V
N
K
E
R
K
S
K
G
L
S
E
L
K
M
D
K
D
L
L
D
V
A
M
Q
R
A
A
E
V
A
L
Y
F
S
H
T
R
P
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
94.86
100%
-62.50
- C- -
M078
-
A:
[10-640]
---------
T
T
I
L
V
L
T
M
V
M
G
F
N
V
P
F
S
A
T
T
V
M
A
A
S
I
T
Y
N
V
S
S
T
I
K
G
V
L
T
D
D
G
V
L
T
I
S
G
T
G
A
M
P
D
Y
T
K
I
A
N
I
P
W
Y
K
D
R
D
R
I
S
E
V
R
V
N
S
G
I
T
S
I
G
E
A
N
F
N
S
C
Y
N
M
T
K
V
T
V
A
S
T
V
T
S
I
G
D
G
A
F
A
D
T
K
L
Q
S
Y
T
G
M
E
R
V
K
K
F
G
D
Y
V
F
Q
G
T
D
L
D
D
F
E
F
P
G
A
T
T
E
I
G
N
Y
I
F
Y
N
S
S
V
K
R
I
V
I
P
K
S
V
T
T
I
K
D
G
I
G
Y
K
A
E
N
L
E
K
I
E
V
S
S
N
N
K
N
Y
V
A
E
N
Y
V
L
Y
N
K
N
K
T
I
L
E
S
Y
P
A
A
K
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
94.69
100%
-74.96
- C- -
M075
-
A:
[17-621]
----------------
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-----------------------
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--------------
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------