@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CTR2_HUMAN: (2015-12-07 )
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.....-..-.80........90...--.....100.......-110....----------....120--..-......130.......140.......150.......160.......170.......180.-......190.......200.......210..-.....220.......230.....------..240.......250...------..---...260........270-.......280.......290.....--..300.......310---.....---------------.-.320.-----........330-........340.......350.......360....---------...370.---......380.......-----390.......400..-------.....410.......420.......430.......440-.......-.450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570..--.....580.......590.....--..600.......610.......620.......630.......640.......650......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIP
C
R
A
A
L
T
F
A
R
C
L
I
R
R
KI
V
T
LDSL
E
D
T
K
L
C
R
C
L
S
T
M
D
L
I
A
L
GVGSTLG
A
G
V
Y
V
L
AGEVAKADS
G
P
S
I
V
V
S
F
L
I
A
A
-
L
A
-
S
V
M
A
G
L
C
Y
A
E
F
GARVP--KTG
S
A
Y
L
Y
T
Y
V
T
V
G
E
-
L
W
-
A
F
I
T
----------
G
W
N
L
I
L
---
S
Y
-
V
IG
T
S
S
V
A
R
A
WSG
T
F
D
E
L
L
S
K
Q
I
G
Q
F
L
R
T
Y
F
RMNYTGLAEY
P
D
F
F
A
V
C
L
I
L
L
L
A
G
L
L
SFG-VK
E
S
A
W
V
N
K
V
F
T
A
V
N
I
L
V
L
L
F
V
M
V
A
G
F
VKGN-VANW
K
I
S
E
E
F
L
K
N
I
S
ASAREPPS------ENG
T
S
I
YGAGGFMP-YGF------TG---
T
L
A
G
A
-
A
T
C
F
Y
A
F
VG
F
D
-
C
IATT
G
E
EVRNPQKAI
P
I
G
I
V
T
S
L
L
--
V
C
F
M
A
Y
F
G
V
S
A
A
L
T
L
---
M
M
P
Y
Y
---------------L-LD--E-----KSPL
P
V
A
F
E
Y--VGWGPA
K
Y
V
V
AAG
S
L
C
A
L
S
T
S
L
L
G
SIFPM
P
R
V
I
Y
A
---------MAED
G
L
L
---
F
K
C
L
A
Q
INSKTKT
P
I
I
-----
A
TLSS
G
A
V
A
A
L
M
A
F
L
-------
F
D
L
K
A
L
V
D
M
M
S
I
G
T
L
M
A
Y
S
L
V
A
A
C
V
L
I
LRYQPGLSYD--QPKCSPE-KDGLGSSPRVTSKSE
S
Q
V
T
M
L
Q
RQGF
S
M
R
T
L
FCPSLLP
T
Q
Q
S
A
S
L
V
S
F
L
V
G
F
L
A
F
L
V
L
G
L
S
V
L
T
T
Y
G
V
H
A
I
T
R
L
E
A
W
S
L
A
L
L
A
L
F
L
V
L
F
V
A
I
V
L
T
I
WRQPQNQ
Q
K
V
A
F
MV
P
F
L
P
F
L
P
A
F
S
I
L
V
N
I
Y
--
L
M
V
Q
LSAD
T
W
V
R
F
S
I
W
M
A
I
G
F
L
I
--
Y
F
S
Y
GIRHSLEGHLRDENNEEDAYPDNV
H
A
AAEEKSAIQANDHHPRNLSS
P
F
I
F
HEKTSEF
28
Fugue
91.75
18%
-102
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
-
G
R
N
L
P
E
T
F
I
L
S
G
-
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
-
T
G
A
L
----------
S
I
L
L
W
M
---
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
--------------
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
I
---------------------------------
P
D
L
A
P
-
S
A
V
------
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
--
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
---------------
E
-
L
I
K
A
S
-----
E
N
A
L
A
V
A
A
K
P
--
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
---------
L
A
K
D
G
E
L
---
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
-----
Y
I
T
--
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
--
I
V
I
-
F
S
F
-
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.05
21%
-117
- C2 -
3GI8
-
Y609_METJA
C:
[6-370]
-------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
N
L
P
E
T
F
I
L
S
G
-
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
----
N
I
I
T
----------
G
A
L
S
I
L
LWM
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
--------
N
I
A
I
T
E
------
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
E
F
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
G
L
I
----------------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
P
-
S
A
V
------
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
--
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
-------------------
I
D
--
E
LIKAS
E
N
A
L
A
V
A
A
K
P
--
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
---------
L
A
K
D
G
E
L
PEF
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
----------
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
--
I
V
I
F
S
F
I
-
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.33
21%
-117
- C2 -
3GI9
-
Y609_METJA
C:
[6-370]
-------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
N
L
P
E
T
F
I
L
S
G
-
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
----
N
I
I
T
----------
G
A
L
S
I
L
L
W
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
-
A
P
I
N
T
F
--------
N
I
A
I
T
E
------
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
----------------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
P
-
S
A
V
------
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
--
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
-------------------
I
D
--
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
--
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
---------
L
A
K
D
G
E
L
PEF
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
----------
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
--
I
V
I
F
S
F
I
-
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.78
21%
-117
- C2 -
3GIA
6
Y609_METJA
A:
[6-370]
-------------------------------
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
N
L
P
E
T
F
I
L
S
G
-
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
----
N
I
I
T
----------
G
A
L
S
I
L
L
W
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
--------
N
I
A
I
T
E
------
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
----------------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
P
-
S
A
V
------
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
--
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
-------------------
I
D
--
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
--
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
---------
L
A
K
D
G
E
L
PEF
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
----------
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
--
I
V
I
F
S
F
I
-
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
86.21
21%
-115
- C2 -
3GIA
6
Y609_METJA
A:
[3-369]
----------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
N
L
P
E
T
F
I
L
S
G
-
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
-
N
I
I
T
G
A
L
----------
S
I
L
L
W
M
---
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
--------------
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
I
P
---------------------------------
D
L
A
P
-
S
A
V
------
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
--
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
---------------
E
-
L
I
K
A
S
-----
E
N
A
L
A
V
A
A
K
P
--
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
---------
L
A
K
D
G
E
L
---
P
E
F
F
E
R
K
V
-
W
F
K
S
T
-
E
-----
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
--
I
V
I
F
S
F
I
-
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
82.18
19%
-124
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-379]
------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
--
T
G
G
I
A
I
Y
G
W
L
V
T
I
-
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
--
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
----------
N
V
L
Y
W
L
---
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
--------------
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
T
Y
M
A
------------------------------------------------
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-
S
-----
A
S
P
F
G
D
A
A
R
M
--
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
-----
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
--
P
A
Y
L
A
V
T
-
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
76.30
14%
-120
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-501]
--------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
-----
V
Y
E
Y
P
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
-
I
L
W
F
I
P
V
G
L
C
A
A
E
M
A
T
--
V
--
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
----------
I
S
F
G
Y
L
---
Q
I
-
A
I
G
-----------------------------------------
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
-
K
W
P
A
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
-
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
------
A
L
A
A
I
Y
L
H
-
T
F
F
P
D
-
F
S
K
------
V
G
---
T
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
-
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
--
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
---
V
I
P
---------------------------------------------
G
N
E
I
N
L
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
---------------------------------
E
W
T
V
R
V
I
S
-----
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V------
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
---------------
P
A
A
F
A
K
M
--
N
K
N
G
V
P
-----------------------------------------
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
--
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
-------------
F
N
I
P
G
G
K
G
--
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
PD
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-------------------
36
Fugue
58.21
16%
-108
- C2 -
5A61
4
?
A:
[2-430]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
A
Q
E
I
E
L
K
F
I
V
N
H
S
A
V
E
A
L
R
D
H
-
L
N
T
L
G
G
E
H
H
D
P
V
Q
L
L
N
I
Y
Y
E
T
P
D
N
W
L
R
G
H
D
M
G
L
R
I
R
G
E
N
G
R
Y
E
-
M
T
M
K
V
A
G
R
V
T
G
---
G
L
H
Q
R
-
P
E
Y
N
V
A
L
S
E
P
T
L
D
L
A
Q
L
P
T
E
V
-
W
P
N
G
E
L
P
A
D
L
A
S
R
V
Q
--
P
L
F
S
T
D
F
Y
R
E
K
W
L
V
A
---
V
-------------------------
D
-----
D
S
R
I
E
I
A
L
D
Q
G
E
V
K
A
G
E
F
A
E
P
I
C
E
L
E
L
E
L
L
S
G
D
T
R
A
V
L
K
L
A
N
Q
L
V
S
Q
TG
L
R
Q
G
SLS
K
A
A
R
G
Y
H
---
L
A
Q
G
N
P
A
R
E
I
K
P
T
T
I
L
H
V
A
AK
A
D
V
E
Q
G
L
E
A
A
F
E
L
A
L
-------
A
Q
W
Q
Y
H
E
E
L
W
V
R
G
N
D
A
A
K
E
Q
V
L
A
A
I
G
L
V
R
H
A
L
M
L
F
G
G
IV
P
R
K
A
S
T
H
L
R
D
L
L
T
Q
C
E
A
T
I
A
S
A
V
S
A
V
T
A
V
Y
S
T
E
T
A
M
A
K
L
A
L
T
E
W
L
V
S
K
A
W
Q
P
F
L
D
--------------------
A
K
A
Q
G
K
I
S
D
S
F
K
R
F
A
D
I
H
L
S
R
H
A
A
E
L
K
S
V
F
C
Q
P
L
G
D
R
Y
H
D
Q
L
P
R
L
T
R
D
I
D
S
I
L
L
L
A
G
Y
Y
D
P
V
V
A
Q
A
W
L
E
N
W
Q
G
L
R
H
A
I
A
T
G
Q
----------
R
I
E
I
E
H
F
R
N
E
A
N
N
Q
E
P
F
W
L
------------------------------------
13
PsiBlast_PDB
54.31
22%
-131
- C2 -
4DJK
-
GADC_ECOLI
A:
[36-260]
-------------------------------------------------------------
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
-
F
I
P
V
G
L
C
A
A
E
M
-
A
T
V
D
GW---
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
---
Y
F
-
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
----------------------
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
------------
L
A
A
I
Y
L
H
------------------
T
---------
F
F
P
D
F
S
K
------
V
G
---
T
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
-
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
---
P
G
N
E
I
---------------
N
-
L
S
--
A
-----
G
V
M
Q
T
F
T
V
L
M
--
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
---------
G
M
Y
V
T
A
Q
---
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
-----
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
-------
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
--
I
V
L
V
L
K
H
-
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.26
22%
-121
- C2 -
4DJI
-
GADC_ECOLI
A:
[36-260]
-------------------------------------------------------------
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
-
F
I
P
V
G
L
C
A
A
E
M
-
A
T
V
D
GW
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
I
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
---
Y
F
-
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
----------------------
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
------------
L
A
A
I
Y
L
H
S
G
---
A
I
E
M
D
S
------
K
T
---------
F
F
P
D
F
S
K
------
V
G
---
T
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
-
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
---
P
G
N
E
I
---------------
N
-
L
S
--
A
-----
G
V
M
Q
T
F
T
V
L
M
--
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
---------
G
M
Y
V
T
A
Q
---
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
-----
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
-------
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
--
I
V
L
V
L
K
H
-
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
N
A
P
K
G
H
F
F
L
H
P
R
A
R
S
P
H
Y
I
V
M
N
D
K
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.77
24%
-62
- C2 -
3NCY
-
ADIC_SALTY
A:
[201-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-
S
-----
A
S
P
F
G
D
A
A
R
M
--
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
------
T
P
V
A
-----
G
L
L
I
V
G
V
L
M
T
I
F
Q
F
S
-------
S
M
S
P
N
A
A
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
--
G
H
F
G
K
A
R
-
P
L
Y
L
L
I
T
F
V
A
F
V
Y
C
I
W
A
V
I
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
L
Y
A
L
N
Y
N
R
I
H
K
N
P
Y
P
L
D
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.20
24%
-46
- C2 -
3L1L
1
ADIC_ECO57
A:
[201-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-
S
-----
A
S
P
F
G
D
A
A
R
M
--
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
-----
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
--
G
H
F
G
K
A
R
-
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
43.92
12%
-81
- C2 -
3DH4
1
?
A:
[53-355]
------------------------------
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
A
I
A
S
Y
E
W
M
S
A
-
I
T
-
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
---
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
-
K
L
-
K
T
I
L
----------
A
V
F
W
I
S
---
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
P
L
----------------
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
-------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
-------------
D
Q
S
N
P
Q
Y
-
M
N
L
------
P
G
IAV
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
-
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
--
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
N
--
A
-----
D
K
A
Y
P
W
L
T
-
Q
--
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
------------
M
D
I
Y
K
---
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
-----
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
-------
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
--
T
S
K
G
A
I
I
-
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.02
24%
-48
- C2 -
3OB6
1
ADIC_ECOLI
A:
[201-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V
-
S
-----
A
S
P
F
G
D
A
A
R
M
--
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
-----
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
-------
S
I
S
P
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
--
R
P
A
Y
L
A
V
-
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.11
24%
-24
- C2 -
3LRB
-
ADIC_ECO57
A:
[201-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
--------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
-----
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
--
G
H
F
G
K
A
R
-
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
40.20
24%
-20
- C2 -
3LRC
-
ADIC_ECO57
A:
[201-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
S
F
I
G
V
E
-
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
--
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
---
M
I
P
N
--------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
---------
A
A
D
D
G
L
F
---
P
P
I
F
A
R
V
N
-
K
A
G
T
P
V
A
-----
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
--
G
H
F
G
K
A
R
-
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.83
34%
-21
- C2 -
3WDO
-
?
A:
[140-191]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
----
W
M
I
A
I
L
A
T
-----
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
--
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
--
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
16
PsiBlast_CBE
37.49
33%
-20
- C2 -
3IL5
1
FABH_ENTFA
C:
[96-156]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
-----
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
-------
F
D
I
S
A
A
C
S
----
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
--
G
E
T
F
S
K
M
-
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
N
M
D
--
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
--
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
-----------------------------------
15
PsiBlast_CBE
37.25
33%
-26
- C2 -
3IL5
1
FABH_ENTFA
D:
[96-156]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
-----
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
-------
F
D
I
S
A
A
C
S
----
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
--
G
E
T
F
S
K
M
-
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
N
M
D
--
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
--
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
-----------------------------------
10
PsiBlast_PDB
37.22
33%
-29
- C2 -
3IL5
1
FABH_ENTFA
A:
[96-156]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
-----
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
-------
F
D
I
S
A
A
C
S
----
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
--
G
E
T
F
S
K
M
-
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
N
M
D
--
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
--
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
-----------------------------------