@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AE_HUMAN: (2015-12-09 )
MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV
Atome Classification :
(20 SA)
.........10........20........30........40.......-----.50........60........70........80......------..90......----------..100.......110.-......120.......130.......140.......150.......160.......170.......180.......190.......----200.......210.....---..220.......------------------230---.----.-......-240....-------------...250--.---........260.......270..-.....280--.......290-.-----------------------------..-----------....300..---.....-------310.-..--....----------.320.......330...---....340.......350..-...--..360.....-...370.......380.......390.....----------------....400-.-.-.----.---..---.---410----.........420.......430--.........440.....---..450.......460...--....470.......480......-----.490----........500.....-..-510......-.520.......-..---530---....------..-..540.--------..-....550.-...-...560.......-570.......580.......590..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAG
E
E
N
F
K
E
E
L
R
S
Q
D
A
SRNL
N
Q
H
EVAGHPHSW
S
L
E
M
L
L
R
R
L
R
A
V
HTKQ-----
D
D
K
F
A
N
L
L
D
A
V
GE
F
G
T
F
Q
Q
R
L
V
A
L
T
F
I
P
S
I
M
S
A
F
F
M
F
A
D
------
H
F
V
F
TAQKPY----------CNT
S
W
I
L
A
VGPHLSKA-
E
Q
L
N
L
TIPQAPNG
S
F
L
T
C
F
M
YLPVPW
N
L
D
S
I
I
Q
FGLNDTDTCQDGWIYP
D
A
K
K
R
S
L
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N
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F
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VCGMETKKD
T
A
Q
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AGL
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L
----
I
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KMGR
Y
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A
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L
L
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---
L
L
G
L
I
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F
G
F
G
T
A
------------------
F
-
M
---N----
S
-
F
H
L
Y
L
F
-
F
RFGIS
Q
-------------
S
V
V
G
----
Y
---
A
I
S
S
I
S
L
A
T
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W
L
VGEHR
A
H
A
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-
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--
A
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---
I
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F
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-
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W
ILP----------ESP
R
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KG
K
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Q
---
V
L
C
Y
AASVNKKTI
P
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V
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Y
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----------------
F
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H
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---
I
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FLPEGEDG
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--
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KWPRC
P
A
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-----FS
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A
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Y
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TGL
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----
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ISQ------TP-
S
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--------
L
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LLPETRDQ
P
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S
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MKTKETSSDDV
11
Fugue
94.78
15%
-131
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
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------
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----------
L
N
T
V
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P
Q
N
L
S
-----------------------------------------
E
S
A
A
N
S
L
L
G
F
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V
A
--------------------------
S
A
L
I
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I
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G
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----
L
G
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---
A
V
L
F
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WPELGFTSINPDNTVPVY
L
-
A
---
G
----
Y
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V
P
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F
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Y
R
I
I
G
G
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-------------
G
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----
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N
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-
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A
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A
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W
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W
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A
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C
---
I
P
A
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L
-------
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-
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--
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----------
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W
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F
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----------------
Y
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A
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----
V
D
K
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R
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P
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I
G
A
L
G
M
---
A
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G
M
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L
G
T
A
F
Y
T
Q
A
-------------
P
G
I
V
A
L
L
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M
L
F
Y
V
A
A
-----
F
A
M
-----
S
W
G
-
P
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L
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N
A
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K
A
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A
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--
A
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W
L
A
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Y
-
F
V
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W
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----
M
M
D
K
------
N
S
-
W
L
V
A
H
F
HNG
F
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Y
W
I
Y
G
-
C
M
G
V
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A
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L
-
F
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F
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P
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K
G
K
T
L
E
E
-
L
E
A
L
W
E
-------------------
19
Fugue
82.58
14%
-123
- C1 -
4UIR
2
OLHYD_ELIME
A:
[2-646]
N
P
I
T
S
K
F
D
K
V
L
N
A
S
S
E
Y
G
H
V
N
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---
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-----
G
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GHVPAK
N
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DGGSL
D
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Y
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R
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L
W
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A
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F
G
L
-----
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L
L
L
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K
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--
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---
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------------------
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---
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LNDLSS
L
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----
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---
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L
D
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-
Q
-----------------------------
D
G
-----------
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GSMTED
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Q
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A
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W
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P
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K
F
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--
M
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N
RQPHFPEQPDD
V
L
V
L
W
V
Y
A
L
F
M
-
D
-
K
-
E
----
G
---
N
Y
---
I
---
K
------
K
T
M
L
E
C
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D
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L
A
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Y
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----
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---
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F
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D
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-----
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V
V
P
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G
C
K
N
L
G
L
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G
Q
F
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N
N
D
V
V
F
T
M
-----
E
S
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A
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L
L
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L
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V
G
E
G
L
--------
L
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K
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--
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T
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Y
F
E
-
H
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A
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I
A
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H
V
N
K
F
R
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W
V
K
G
I
R
G
--------
21
HHSearch
73.18
14%
-148
- C3 -
3WDO
-
?
A:
[39-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
Q
G
A
S
---
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
----
P
F
G
L
L
S
D
R
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G
---
L
A
V
F
A
A
G
S
V
I
A
A
------------------
L
-
S
---
D
----
S
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I
W
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L
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-------------
G
A
------
I
---
A
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A
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T
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A
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A
F
-
I
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--
F
A
I
A
M
V
L
G
P
I
-
I
T
H
K
--------------------------
L
G
-----------
L
H
A
L
F
W
M
I
A
---
I
L
A
T
T
-------
G
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--
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----------
N
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----
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-----------------------------------
G
M
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K
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-
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F
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M
C
L
H
M
L
--
L
M
S
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----------------
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A
L
P
G
Q
L
-
A
-
D
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A
----
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---
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A
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H
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Y
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Y
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----
K
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K
Q
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F
C
V
G
L
I
---
V
V
A
E
I
V
L
W
N
A
Q
T
------------------
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
-----
V
A
F
-----
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
-
A
G
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Y
K
G
T
A
M
G
V
Y
-
S
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--
S
Q
F
L
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A
-
I
G
---
G
S
L
G
G
W
I
D
G
M
------
F
D
-
G
Q
G
V
F
L
--------
A
G
-
A
M
L
A
A
V
W
L
-
A
V
A
-
S
T
M
K
E
P
P
Y
V
S
S
L
R
-
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N
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A
L
K
V
R
L
L
E
T
E
G
V
K
E
18
Fugue
67.86
14%
-122
- C3 -
3VS8
-
?
A:
[7-410]
-
H
P
N
S
A
V
L
A
D
F
I
P
V
Q
L
A
K
P
--------
V
P
Q
R
I
T
L
E
L
T
A
Y
G
F
A
R
A
H
C
L
S
N
GITD
E
E
G
F
V
Q
V
Y
K
T
V
K
E
--
K
F
D
K
Y
A
V
S
P
A
Q
I
K
Q
R
Q
L
V
Y
F
P
K
L
T
------
D
I
R
F
G
----------------
D
G
N
F
D
I
A
D
P
E
P
D
Q
A
H
-
L
R
L
-
F
D
I
K
K
D
P
R
G
-----------------------------
A
D
L
K
T
R
H
E
S
Y
A
K
V
V
G
K
G
L
E
Q
M
F
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G
T
L
E
A
P
D
D
L
I
H
V
T
C
S
G
Y
L
A
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S
----
P
A
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R
M
V
A
D
R
G
W
F
E
T
T
V
T
H
---
S
Y
N
M
G
C
Y
G
A
F
P
A
------------------
I
-
K
---
M
----
A
-
H
G
M
L
A
S
-
A
Q
W
G
A
T
P
-------------
P
K
T
R
----
V
---
D
I
A
H
T
E
L
M
S
A
H
N
N
I
A
E
S
R
V
D
N
I
I
-
S
A
T
L
F
S
D
G
--
L
I
-----
K
Y
S
-
V
-----------------------------
Y
P
-----------
E
D
E
L
R
R
Q
G
L
---
R
G
L
R
I
-------
L
A
-
M
-
S
E
--
H
L
L
P
----------
D
S
----------------------
A
D
T
M
T
G
V
P
-------------------------------------------------------------------------------
G
-
S
-
H
----
Q
---
F
V
---
M
---
T
------
L
S
P
L
V
P
A
I
I
K
R
H
V
R
A
F
A
V
D
L
----
L
R
R
A
G
M
D
F
E
R
D
K
D
A
L
S
F
---
A
I
H
P
G
G
P
K
I
V
D
H
V
Q
E
E
L
G
--
L
A
-------
E
D
Q
V
A
I
S
K
S
V
F
L
E
N
-----
G
N
M
-----
S
S
S
T
I
P
H
I
L
K
A
Y
L
E
E
A
-
T
V
G
T
R
I
A
C
L
G
F
G
-
P
G
--
L
T
A
A
G
L
V
-
L
E
---
K
I
--------------------------------------------------------------------------------------
12
Fugue
64.48
10%
-113
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
-----
R
K
N
F
A
L
A
M
P
Y
L
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
------
G
S
V
S
D
R
-----------------------------------------------------------------------------------------------------------------------------
S
N
P
R
V
F
L
P
A
G
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
W
------------------
A
-
T
---
S
----
S
-
I
A
V
M
F
V
-
L
L
F
L
C
G
W
-------------
F
Q
G
M
----
G
---
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
--
G
G
I
P
P
L
L
F
L
L
-
G
-----------------------------
M
A
WFND-------
W
H
A
A
L
Y
M
P
A
---
F
C
A
I
L
-------
V
A
-
L
-
F
A
--
F
A
M
M
----------
R
D
T
P
-------------------
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
-
K
Q
I
--
F
M
Q
Y
-
V
L
P
N
K
-
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
---
P
T
Y
L
K
----------------
E
V
K
H
F
A
L
-
D
-
K
-
S
----
S
---
W
A
---
Y
---
F
------
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
----
F
R
--
G
N
R
G
A
T
G
V
F
F
M
T
L
---
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
-----------
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
-----
P
V
M
-----
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
-
T
A
-
A
G
F
T
G
L
F
G
Y
-
L
G
--
G
S
V
A
A
S
A
-
I
V
---
G
Y
----
T
V
D
F
------
F
G
-
W
D
G
G
F
M
--------
V
M
-
I
G
G
S
I
L
A
V
-
I
L
L
-
I
V
V
M
I
G
E
K
R
R
H
E
Q
-
L
L
Q
E
L
V
P
------------------
22
HHSearch
63.28
15%
-120
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[49-399]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
F
Q
Q
A
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
----
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
------------------
P
-
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
-
G
L
F
I
I
A
A
-------------
G
L
G
C
----
L
---
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
--
A
I
I
A
V
V
F
G
Q
S
-
L
ILSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-----------
V
Q
T
P
Y
M
I
I
V
---
A
I
V
L
L
-------
V
A
-
L
-
L
I
M
L
T
K
F
P
----------
A
L
Q
S
D
-----
N
H
S
D
A
--------------------------------
K
Q
-
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
--
Q
T
A
C
W
----------------
S
Y
L
I
R
Y
A
V
E
-
E
I
P
----
G
---
M
T
---
A
G
F
A
A
------
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
----
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
---
M
A
L
C
L
I
S
A
F
A
G
G
-------------------
H
V
-
G
L
I
A
L
T
L
C
S
-----
A
F
M
-----
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
-
Q
D
-
T
K
-
Y
G
S
S
F
I
--
V
--
M
T
I
I
G
G
G
-
I
V
---
T
P
----
V
M
G
F
------
V
S
-
D
A
A
G
N
I
--------
P
T
-
A
E
L
I
P
A
L
C
-
F
A
V
-
I
F
I
F
A
R
F
R
S
Q
T
----------------------------
20
HHSearch
59.31
12%
-138
- C3 -
1PW4
-
GLPT_ECOLI
A:
[56-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
----
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
------------------
F
-
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
-
L
L
F
L
C
G
W
-------------
F
Q
G
M
----
G
---
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
--
G
G
I
P
P
L
L
F
L
L
-
G
M
AWF-------------------------
N
D
-----------
W
H
A
A
L
Y
M
P
A
---
F
C
A
I
L
-------
V
A
L
F
-
A
F
--
A
M
M
R
----------
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
--
R
Y
G
I
L
----------------
D
W
S
P
T
Y
L
-
K
-
E
V
K
----
H
---
F
A
L
D
K
S
---
S
------
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
----
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
-----------------
G
N
P
T
V
D
M
I
C
M
I
V
I
G
-----
F
L
I
-----
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
-
K
K
-
A
A
G
T
A
A
G
F
T
-
G
L
--
F
G
Y
L
G
G
S
V
A
A
---
S
A
I
V
G
Y
T
V
D
F
------
F
G
-
W
D
G
G
F
M
--------
V
M
-
I
G
G
S
I
L
A
V
-
I
L
L
-
I
V
V
M
I
G
E
K
R
R
H
E
Q
-
L
L
Q
E
L
V
P
------------------
16
Fugue
59.24
11%
-98
- C3 -
1KPL
1
CLCA_SALTY
A:
[31-460]
-----------------------------
T
P
L
A
I
L
F
M
A
A
V
V
G
T
L
T
G
L
V
-----
G
V
A
F
E
K
A
V
S
W
V
Q
N
M
R
I
G
A
L
V
Q
V
A
D
H
A
F
L
L
W
P
L
A
F
I
L
S
A
L
------
L
A
M
V
G
Y
F
L
V
R
----------
K
F
A
---------------------
P
E
A
G
G
S
G
I
P
E
I
E
G
A
L
E
E
L
--------------------------------
R
P
V
R
W
W
R
V
L
P
V
K
F
I
G
G
M
G
T
L
G
A
G
M
V
L
G
R
---------------
E
G
P
T
V
Q
I
G
---
G
N
L
G
R
M
V
L
D
V
F
R
------------------
M
-
R
---
S
----
A
-
E
A
R
H
T
L
-
L
A
T
G
A
A
A
-------------
G
L
S
A
----
A
F
NA
P
L
A
G
I
L
F
I
I
E
E
M
R
P
Q
F
R
Y
N
L
I
S
I
-
K
A
V
F
T
G
V
I
--
M
S
S
I
V
F
R
I
F
N
--------------------------------------------------------------------------------
G
----------
E
A
P
I
I
E
V
G
K
L
S
D
A
P
V
N
T
---
L
W
L
Y
L
I
L
G
I
I
F
G
V
V
G
P
V
F
N
-
S
L
V
--
L
R
T
Q
-
D
M
F
Q
R
-
F
H
G
G
E
I
K
K
W
V
L
M
G
G
A
I
G
G
L
C
G
I
L
G
--
L
I
E
------------------------
P
-
A
-
A
-
A
----
G
---
G
G
---
F
---
N
------
L
I
P
I
A
A
A
G
N
F
S
V
G
L
L
L
F
I
F
I
----
T
R
V
V
T
T
L
L
C
F
S
S
G
A
P
G
G
---
I
F
A
P
M
L
A
L
G
T
L
L
G
T
A
F
G
M
--
A
A
A
V
L
F
P
Q
Y
H
L
E
A
G
T
F
A
I
A
G
M
-------------------------------------
G
A
L
M
A
A
S
-
V
R
--
A
P
L
T
G
I
V
-
L
V
---
L
E
----
M
T
D
N
------
Y
Q
-
L
I
L
P
M
I
--------
I
T
-
C
L
G
A
T
L
L
A
-
Q
F
------------------
L
G
G
K
P
L
Y
S
T
I
L
A
R
T
L
A
K
Q
D
A
E
Q
-
24
HHSearch
56.86
11%
-128
- C3 -
2CFQ
-
LACY_ECOLI
A:
[37-393]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
H
I
S
---
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
----
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
------------------
F
-
G
---
P
----
L
L
Q
Y
N
I
L
V
-
G
S
I
V
G
G
I
-------------
Y
L
G
F
CFNA
G
---
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
--
W
A
L
G
A
S
I
V
G
I
-
M
F
T
---------------------------
I
N
-----------
N
Q
F
V
F
W
L
G
S
---
G
C
A
L
I
-------
L
A
-
V
-
L
L
--
F
F
A
K
----------
T
D
A
P
S
S
--
A
T
V
A
N
A
V
G
-------------
A
N
----------------
H
S
-
A
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
--
Y
D
V
F
D
----------------
Q
Q
F
A
N
F
F
-
T
-
S
-
F
FAT
G
E
---
Q
G
T
R
V
F
---
G
------
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
----
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
---
S
V
R
I
I
G
S
S
F
A
T
S
-------------------
A
L
E
V
V
I
L
K
T
L
H
M
-----
F
E
V
-----
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
-
V
R
-
F
S
A
T
I
Y
L
V
C
F
C
F
--
F
K
Q
L
A
M
I
-
F
M
---
S
V
L
A
G
N
M
Y
E
S
------
I
G
-
F
Q
G
A
Y
L
--------
V
L
-
G
L
V
A
L
G
F
T
-
L
I
S
-
V
F
T
L
S
G
P
G
P
L
S
L
L
-
R
R
Q
V
N
E
V
A
-----------------
23
HHSearch
53.16
13%
-86
- C3 -
2GFP
-
EMRD_ECOLI
A:
[31-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
M
A
R
D
L
N
V
R
---
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
----
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
------------------
T
-
T
---
S
----
S
-
L
T
V
L
I
A
-
A
S
A
M
Q
G
M
-------------
G
T
G
V
----
G
---
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
--
P
L
L
A
P
L
I
G
G
L
-
L
DTM--------------------------
W
N
-----------
W
R
A
C
Y
L
F
L
L
---
V
L
C
A
G
-------
V
T
-
F
S
M
A
--
R
W
M
P
----------
E
T
R
P
V
D
-----
A
P
--
R
----------------------------------
T
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
--
I
A
A
F
E
----------------
A
C
S
G
V
L
M
-
G
A
V
-
L
----
G
---
L
S
---
S
---
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
----
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
---
A
G
L
L
M
W
I
P
D
W
F
G
----------------
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
-----
F
G
A
-----
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
--
F
-
L
A
G
T
A
G
A
L
V
-
G
G
--
L
Q
N
I
G
S
G
-
V
L
---
A
S
----
L
S
A
M
------
L
P
-
Q
T
G
Q
G
S
--------
L
G
-
L
L
M
T
L
M
G
L
-
L
I
V
-
L
C
W
L
P
L
---------------------------------
7
PsiBlast_PDB
47.65
25%
-108
- C3 -
4LDS
-
?
A:
[65-201]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
D
K
L
G
R
R
R
L
V
M
L
I
---
A
I
V
F
I
I
G
A
L
I
L
A
------------------
A
-
S
---
T
----
N
-
L
A
L
L
I
I
-
G
R
L
I
I
G
L
-------------
A
V
G
G
----
S
---
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
-
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
A
D
I
-----------------------------
E
G
-----------
W
R
W
M
L
---
G
---
L
A
V
V
P
S
V
I
----
L
L
-
V
-
G
I
--
Y
F
M
P
----------
E
S
P
R
W
L
L
E
N
R
N
E
E
A
A
R
Q
---
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
-
E
I
N
--
A
I
S
E
-
S
T
W
T
V
-
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
--
I
N
A
V
I
----------------
F
Y
S
S
S
I
F
-
A
-
K
-
A
----
G
---
L
G
---
E
---
A
------
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
----
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
---
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
--
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
-----
G
P
V
-----
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
-
A
T
-
G
I
S
A
L
V
L
N
I
-
G
T
--
L
I
V
S
L
F
F
-
P
I
---
L
S
----
D
A
L
S
------
T
E
-
W
V
F
L
I
F
--------
A
F
-
I
G
V
L
A
M
I
F
-
V
I
K
-
F
L
P
E
T
R
G
--------------------------------
3
PsiBlast_PDB
45.40
21%
-37
- C4 -
4GC0
3
XYLE_ECOLI
A:
[199-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
-------
F
L
-
M
-
L
L
--
Y
T
V
P
----------
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
---
I
L
---
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
-
E
I
K
H
S
L
D
H
G
-
R
K
T
G
G
-
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
--
I
N
V
V
L
----------------
Y
Y
A
P
E
V
F
-
K
-
T
-
L
----
G
---
A
S
---
T
---
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
----
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
-----
L
L
S
-----
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
-
A
A
-
Q
W
L
A
N
Y
F
V
S
-
W
T
--
F
P
M
M
D
K
N
-
S
W
---
L
V
----
A
H
F
H
------
N
G
-
F
S
Y
W
I
Y
--------
G
C
-
M
G
V
L
A
A
L
F
-
M
W
K
-
F
V
P
E
T
K
G
K
T
L
E
E
L
-
E
A
L
W
E
--------------------
15
Fugue
44.37
16%
-73
- C2 -
4C47
-
?
A:
[3-193]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
F
A
D
K
H
L
V
E
-
E
M
K
--
E
Q
Q
K
E
Q
E
T
K
I
-
N
L
L
E
K
Q
Q
K
E
Q
E
A
K
I
N
L
L
E
K
Q
Q
A
T
I
--
I
N
T
T
K
----------------
K
V
T
E
V
V
G
-
R
-
V
-
E
----
R
---
K
Q
---
R
---
L
------
F
D
Y
T
E
L
D
----
P
S
Q
T
H
Y
F
I
I
N
NGN
I
G
L
A
G
R
I
L
S
I
E
P
I
D
N
G
S
---
V
I
H
L
D
L
V
N
L
L
S
I
P
V
S
N
L
A
F
N
M
T
W
G
T
K
K
P
S
E
A
K
D
L
P
R
W
K
Q
L
L
L
N
-----
T
K
M
-----
D
S
T
I
E
---
L
L
P
G
A
W
T
N
-
V
T
-
L
T
L
K
G
V
S
P
N
-
N
L
--
K
Y
L
K
I
G
I
-
D
M
---
E
N
----
V
I
F
D
------------------------------------------------------------------------------
29
HHSearch
43.29
15%
-80
* C3 *
2CFQ
-
LACY_ECOLI
A:
[258-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
----
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
------------------
F
-
A
---
T
----
S
-
A
L
E
V
V
I
-
L
K
T
L
H
M
F
-------------
E
V
P
F
----
L
---
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
--
M
I
F
M
S
V
L
A
G
N
-
M
Y
E
S
--------------------------
I
G
-----------
F
Q
G
A
Y
L
V
L
G
---
L
V
A
L
G
-------
F
T
-
L
-
I
S
--
V
F
T
L
----------
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
42.82
21%
-36
- C4 -
4GBY
3
XYLE_ECOLI
A:
[199-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
-------
F
L
-
M
-
L
L
--
Y
T
V
P
----------
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
---
I
L
---
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
-
E
I
K
H
S
L
D
H
G
-
R
K
T
G
G
-
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
--
I
N
V
V
L
----------------
Y
Y
A
P
E
V
F
-
K
-
T
-
L
----
G
---
A
S
---
T
---
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
----
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
-----
L
L
S
-----
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
-
A
A
-
Q
W
L
A
N
Y
F
V
S
-
W
T
--
F
P
M
M
D
K
N
-
S
W
---
L
V
----
A
H
F
H
------
N
G
-
F
S
Y
W
I
Y
--------
G
C
-
M
G
V
L
A
A
L
F
-
M
W
K
-
F
V
P
E
T
K
G
K
T
L
E
E
L
-
E
A
L
W
E
--------------------
2
PsiBlast_PDB
42.60
21%
-41
* C4 *
4GBZ
3
XYLE_ECOLI
A:
[199-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
-------
F
L
-
M
-
L
L
--
Y
T
V
P
----------
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
---
I
L
---
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
-
E
I
K
H
S
L
D
H
G
-
R
K
T
G
G
-
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
--
I
N
V
V
L
----------------
Y
Y
A
P
E
V
F
-
K
-
T
-
L
----
G
---
A
S
---
T
---
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
----
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
-----
L
L
S
-----
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
-
A
A
-
Q
W
L
A
N
Y
F
V
S
-
W
T
--
F
P
M
M
D
K
N
-
S
W
---
L
V
----
A
H
F
H
------
N
G
-
F
S
Y
W
I
Y
--------
G
C
-
M
G
V
L
A
A
L
F
-
M
W
K
-
F
V
P
E
T
K
G
K
T
L
E
E
L
-
E
A
L
W
E
--------------------
25
HHSearch
41.98
13%
-143
- C3 -
3WDO
-
?
A:
[50-187]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
----
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
---
A
A
G
S
V
I
A
A
L
S
D
S
-------------------
I
W
G
I
I
L
G
R
A
L
Q
G
-----
S
G
-------
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
-
E
Q
-
N
R
T
K
A
M
A
F
I
-
G
V
--
S
F
G
I
T
F
A
-
I
A
---
M
V
L
G
P
I
I
T
H
K
------
L
G
-
L
H
A
L
F
W
--------
M
I
-
A
I
L
A
T
T
G
I
-
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
-
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
4
PsiBlast_PDB
41.45
21%
-36
- C4 -
4JA3
-
XYLE_ECOLI
A:
[199-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
-------
F
L
-
M
-
L
L
--
Y
T
V
P
----------
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
---
I
L
---
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
-
E
I
K
H
S
L
D
H
G
-
R
------------
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
--
I
N
V
V
L
----------------
Y
Y
A
P
E
V
----------------
S
---
T
---
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
----
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
-----
L
L
S
-----
E
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
-
V
S
-
W
T
F
P
M
M
D
K
N
-
S
H
--
N
G
F
S
Y
W
I
-
Y
G
---
C
M
----
G
V
L
A
------
A
L
-
F
M
W
K
F
V
--------
P
E
-----------------------------------------------------
17
Fugue
41.38
17%
-7
- C3 -
1MZG
-
SUFE_ECOLI
A:
[3-146]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
D
K
E
K
L
L
--
R
N
F
L
R
C
A
N
W
E
E
K
Y
L
Y
I
I
E
L
G
Q
R
L
-----
P
E
L
RDEDR
S
P
Q
N
S
I
Q
G
C
Q
S
Q
V
W
I
V
M
R
Q
-
N
A
Q
G
I
I
E
L
Q
-
G
D
S
D
A
A
I
V
K
G
L
-
I
A
---
V
V
----
F
I
L
Y
------
D
Q
M
T
P
Q
D
I
V
--------
N
F
-
D
V
R
P
W
F
E
K
M
A
L
T
-
Q
H
L
T
P
S
R
S
Q
G
L
E
A
M
I
----
R
A
I
R
A
K
A
A
A
L
S
L
E
H
H
H
H
H
H
-
6
PsiBlast_PDB
38.85
35%
20
- C4 -
4J05
-
?
A:
[434-497]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
T
F
I
V
A
A
E
L
F
P
-
T
R
-
I
R
A
S
A
H
G
I
S
-
A
A
--
A
G
K
C
G
A
I
-
L
S
---
S
L
----
V
F
N
Q
L
K
A
K
IG
T
S
-
A
V
L
W
I
F
--------
F
S
T
C
I
L
G
F
I
S
T
-
F
L
I
-
D
E
T
M
G
V
D
P
D
E
K
D
L
-
E
E
R
R
A
R
-------------------