@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35F2_HUMAN: (2015-12-10 )
MEADSPAGPGAPEPLAEGAAAEFSSLLRRIKGKLFTWNILKTIALGQMLSLCICGTAITSQYLAERYKVNTPMLQSFINYCLLFLIYTVMLAFRSGSDNLLVILKRKWWKYILLGLADVEANYVIVRAYQYTTLTSVQLLDCFGIPVLMALSWFILHARYRVIHFIAVAVCLLGVGTMVGADILAGREDNSGSDVLIGDILVLLGASLYAISNVCEEYIVKKLSRQEFLGMVGLFGTIISGIQLLIVEYKDIASIHWDWKIALLFVAFALCMFCLYSFMPLVIKVTSATSVNLGILTADLYSLFVGLFLFGYKFSGLYILSFTVIMVGFILYCSTPTRTAEPAESSVPPVTSIGIDNLGLKLEENLQETHSAVL
Atome Classification :
(18 SA)
----------------.........10........20........30........40...------------.....50....-----....60........70---...-----.....80..-...------...90........100.......110......-------------------.120.......130......-.140.....---..150.......160....----...170.......180.......190.-----......-200.......210---.......220......---------.230....--------...240.......250......-.260.--......270..-------------------------.....280.......290-.-......300.......310.......320.---...--...330.....----------------..340.......350.......360........370..----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MEADSPAGPGAP
E
P
L
AE
G
A
A
A
E
F
S
S
L
L
R
R
IKGKL
F
T
W
N
I
L
K
T
I
A
------------
L
G
Q
M
L
S
L
C
IC
G
-----
T
A
I
T
S
Q
Y
L
A
E
R
YKVN
T
---
P
M
L
-----
Q
S
F
I
N
Y
C
L
L
-
F
L
I
------
Y
T
V
M
L
A
FRSGSD
N
L
L
V
I
L
K
R
K
W
W
K
Y
I
L
L
G
L
AD-------------------VEA
N
Y
V
I
V
R
A
Y
Q
Y
T
T
L
T
S
V
Q
-
L
L
D
CFG
I
P
V
---
L
M
A
L
S
W
F
I
L
H
A
R
Y
R
V
I
H
F
I
----
A
V
A
V
C
L
L
G
V
G
T
M
V
G
A
D
I
LAGREDNSGS-----D
V
L
I
G
D
-
I
L
V
L
L
G
A
S
L
Y
A
I
S
---
N
V
C
E
E
Y
I
V
K
K
L
S
R
Q
E
F
---------
L
G
M
V
G
L
F
G
--------
T
I
I
S
G
I
Q
L
L
I
V
E
Y
K
D
I
A
S
I
HWD-
W
K
I
A
L
--
L
F
V
A
F
A
L
C
M
F
C
-------------------------
L
Y
S
F
M
P
L
V
I
K
V
TSA
T
S
V
N
-
L
-
G
I
L
T
A
D
L
Y
S
L
F
V
G
L
F
L
F
G
YKFS
G
L
Y
I
L
S
F
T
---
V
I
M
--
V
G
F
I
LYCSTPT----------------RTAEPAESSVPPV
T
S
IGIDNLG
L
-
K
L
E
E
N
L
Q
E
T
H
SAVL----------------------------------------------
20
Fugue
79.32
10%
-124
- C4 -
2XEP
1
?
A:
[7-434]
----------------
S
V
P
T
P
A
E
A
A
L
A
A
Q
T
A
L
A
A
D
D
S
P
M
G
D
A
A
R
W
A
M
G
L
L
T
R
P
E
D
V
A
A
R
F
------------
I
P
T
F
N
-----------
F
A
E
T
V
R
E
W
R
S
K
G
P
F
T
V
---
R
A
Y
-----
H
P
V
A
H
K
G
W
V
-
V
L
S
A
P
AG
V
R
Y
I
L
S
L
T
L
D
S
S
G
L
I
R
I
L
T
L
K
P
E
T
V
I
P
D
M
V
T
W
N
D
-------------------
V
E
E
T
L
H
T
P
G
V
Q
H
S
V
Y
A
V
R
L
T
-
P
D
G
H
E
V
L
H
A
---
S
A
P
E
R
P
M
P
T
G
S
A
Y
K
L
Y
L
M
R
----
A
L
V
A
E
I
E
K
G
T
V
G
W
D
E
I
L
T
L
T
P
E
L
R
S
L
P
TGDMQ
D
L
P
D
G
T
-
R
V
T
V
R
E
T
A
H
K
M
I
A
LSD
N
T
G
A
D
L
V
A
D
R
L
G
R
E
V
V
---------
E
R
S
L
A
A
A
G
HHDPSLMR
P
F
L
T
S
H
E
V
F
E
L
G
W
G
D
-
P
E
R
R
A
E
-
W
V
R
Q
D
--
E
A
G
R
R
E
L
L
E
K
M
AGVMTVRGSDLGATVHQLGI
D
W
H
M
D
A
F
D
V
V
R
V
L
E
G
L
L
Q
D
S
G
R
D
-
T
-
S
G
T
V
E
E
I
L
T
A
Y
P
G
L
L
I
D
E
E
R
W
R
R
V
Y
F
K
A
G
S
S
PG
V
M
M
--
F
C
W
L
L
Q
D
H
A
G
I
----------------
S
Y
V
L
V
L
R
Q
S
A
D
E
Q
R
L
I
G
D
G
L
F
L
R
-
G
I
G
A
K
I
I
E
A
E
A
K
L
L
SS--------------------------------------------
17
Fugue
78.80
14%
-111
- C2 -
3GEB
-
EYA2_HUMAN
A:
[1-274]
--------------------------------------------
S
H
M
E
R
V
F
V
W
D
L
D
E
T
I
I
------------
I
F
H
S
L
L
-------------
T
G
T
F
A
S
R
Y
G
K
--------------------------------------------
D
T
T
T
S
V
R
I
G
L
M
M
E
E
M
I
F
N
L
A
D
-------------------
T
H
L
F
F
N
D
L
E
D
C
D
Q
I
H
V
D
D
V
S
-
S
D
D
-
N
G
Q
D
L
STY
N
F
S
A
D
G
F
G
G
V
D
W
M
R
K
L
A
F
R
----
Y
R
R
V
K
E
M
Y
N
T
Y
K
N
N
V
G
G
L
I
G
T
P
K
R
E
T
W
-----
L
Q
L
R
A
E
-
L
E
A
L
T
D
L
W
L
T
H
S
L
---
K
A
L
N
L
I
N
S
R
P
----------------------------------
N
C
V
N
V
L
V
T
T
T
Q
-------------
L
--
I
P
A
L
A
K
V
L
L
Y
G
-------------------------
L
G
S
V
F
P
-
I
E
N
I
Y
S
A
T
K
T
G
----------------------
K
E
S
C
F
E
R
I
M
Q
R
---
F
G
R
--
K
A
V
Y
V
V
I
G
D
G
V
----------------
E
E
E
Q
G
A
K
K
H
N
M
P
F
W
R
I
S
C
H
A
D
L
E
-
A
L
R
H
A
L
E
L
E
Y
L
-------------------------------------------------
13
Fugue
78.07
15%
-88
- C5 -
3HM6
-
X:
[72-638]
IPFLDYKVYAERIFFP
G
H
S
P
L
H
R
D
L
G
V
P
E
S
R
R
P
T
V
E
Q
G
L
G
Q
L
S
N
L
L
N
S
K
L
F
L
T
K
F
I
H
T
L
E
TQRTFSARDRAY
V
A
S
L
L
T
V
A
L
H
G
KLEYF
T
D
I
L
R
T
L
L
S
D
L
V
A
Q
Y
V
AKN
P
K
L
MLRRT
E
T
V
V
E
K
L
L
T
N
W
M
S
------
I
C
L
Y
T
F
V
R
D
S
V
G
E
P
L
Y
M
L
F
R
G
I
K
H
Q
V
D
K
G
P
V
D
SVTGKAKYTLNDNRLLRED
V
E
Y
R
P
L
T
L
N
A
L
L
A
A
Q
G
V
P
V
K
-
V
L
D
C
---
D
T
---
I
S
Q
A
K
E
K
M
L
D
Q
L
Y
K
G
V
P
L
T
QRPD
P
R
T
L
D
V
E
W
R
S
G
V
A
G
H
L
I
L
---
S
D
E
D
V
T
-----
S
E
V
Q
G
L
-
W
R
R
L
N
T
L
Q
H
Y
K
V
P
---
D
G
A
T
V
A
L
V
P
C
G
G
I
R
P
W
HLVKPSIPE
I
Y
L
T
R
L
L
S
--------
M
K
G
T
L
Q
K
F
V
D
D
L
F
Q
V
I
L
S
T
S
R
P
-
V
P
L
A
V
KY
F
F
D
L
L
D
E
Q
A
Q
Q
-------------------------
H
G
I
S
D
Q
D
T
I
H
I
W
K
T
N
S
L
P
-
L
-
R
F
W
I
N
I
I
K
N
---
P
Q
F
V
F
D
V
Q
T
S
D
N
M
D
A
V
L
L
---
V
I
A
--
Q
T
F
M
D
A
C
T
L
A
D
SPINKLLYARDIPRYK
R
M
V
E
R
Y
Y
A
D
I
R
Q
T
V
P
A
S
D
Q
E
M
N
S
-
V
L
A
E
L
S
W
N
Y
S
G
D
L
G
ARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVE
21
Fugue
73.55
15%
-98
- C3 -
4ECF
9
?
A:
[2-261]
---------------A
G
E
S
I
T
A
V
G
S
T
A
L
Q
P
L
V
E
A
A
G
E
Q
Y
T
G
E
H
L
G
T
F
I
N
V
Q
G
G
G
T
G
T
G
L
S
------------
Q
I
Q
E
G
A
V
Q
I
G
N
-----
S
D
L
---
F
A
G
E
Q
K
G
I
N
A
---
R
Q
L
-----
V
D
H
---------------------------------------
R
V
A
V
V
G
I
T
P
-------------------
I
V
N
K
K
V
-----
G
V
K
N
L
S
T
N
Q
-
L
I
K
I
F
T
G
Q
I
---
T
---
N
W
K
E
V
G
G
A
D
Q
S
I
V
L
I
----
N
R
A
Q
G
S
-
G
T
R
A
T
F
E
Q
F
G
L
A
N
H
R
S
K
T
A
Q
-----
E
Q
D
S
S
G
M
V
R
S
I
V
A
T
T
P
G
A
I
S
---
Y
V
A
F
S
Y
V
N
K
T
V
Q
A
L
S
L
---------
N
H
V
A
P
----------------------
T
E
V
N
V
T
T
N
D
W
R
I
W
S
Y
E
H
--
L
Y
T
K
G
H
------------------------------------------------------
P
T
G
L
T
K
A
F
I
T
Y
V
Q
-----------------------------------------------------
S
P
A
I
Q
N
T
L
V
R
Q
L
G
Y
L
S
P
D
Q
M
L
V
E
R
D
A
N
G
H
I
T
K
T
-----------------------------------------------
1
PsiBlast_PDB
48.46
32%
47
- C5 -
2LQU
-
DBPA_BORBU
A:
[111-169]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
A
M
Y
D
L
M
F
E
---
V
S
K
--
P
L
Q
K
L
G
I
Q
E
M
T
----------------
K
T
V
S
D
A
A
E
E
N
P
P
T
T
A
Q
G
V
L
E
I
A
K
-
K
M
R
E
K
L
Q
R
V
H
T
K
N
Y
----------------------------------------------
7
HHSearch
45.84
14%
-218
- C- -
3B5D
1
EMRE_ECOLI
A:
[33-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
T
I
I
C
Y
-------------------
C
A
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
---
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
----
G
M
M
L
I
C
A
G
V
L
I
I
N
L
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
43.51
10%
-211
- C- -
3B5D
1
EMRE_ECOLI
A:
[39-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Y
C
A
-------------------------
S
F
W
L
L
A
Q
T
L
A
Y
I
P
T
G
I
A
Y
A
I
-
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
I
G
M
M
---
L
I
C
--
A
G
V
L
I
I
N
L
L
S
-----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.59
23%
9
- C5 -
4W8L
-
XYNC_PAEBA
A:
[96-137]
-----------------
D
P
N
D
P
S
K
P
A
T
R
E
Q
L
M
Q
R
M
K
T
H
I
Q
T
I
V
S
R
Y
K
G
K
V
H
T
W
D
V
V
N
E
V
I
------------
S
D
G
G
G
L
R
N
Q
A
S
-----
G
S
K
W
R
D
I
I
G
D
V
D
G
D
G
D
---
D
S
D
-----
Y
I
E
L
A
F
R
Y
A
-
R
E
A
------
D
P
D
A
V
L
V
I
N
D
Y
G
I
E
G
S
V
S
K
M
N
D
M
V
K
L
V
E
K
L
L
A
-------------------
K
G
T
P
I
D
A
I
G
F
Q
M
H
V
S
M
Y
G
P
D
-
I
K
Q
I
R
E
A
F
N
---
R
A
A
A
L
G
V
H
I
Q
V
T
E
L
D
M
S
I
Y
----
S
G
N
S
E
Q
E
K
P
V
T
D
E
M
M
L
E
Q
A
Y
R
Y
R
A
L
F
D
-----
L
F
K
E
F
D
-
D
R
G
V
M
D
S
V
T
L
W
G
L
---
A
D
D
G
T
W
L
D
D
F
P
V
K
G
R
K
---------
D
A
P
L
L
F
D
R
--------
K
L
K
A
K
P
A
Y
W
A
L
V
D
P
S
T
L
P
V
Y
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
33.51
17%
190
* C5 *
2KYA
-
?
A:
[1-34]
-----------------
M
N
K
K
N
I
L
P
Q
Q
G
Q
P
V
I
R
L
T
A
G
Q
L
S
S
Q
L
A
E
L
S
E
E
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
32.16
41%
133
- C5 -
4R1D
-
?
B:
[171-207]
---------------------
P
E
H
P
G
A
R
F
E
F
R
S
S
T
G
A
E
L
N
S
L
L
E
R
V
D
G
--
F
V
Q
N
M
L
S
T
F
A
------------
G
M
E
T
L
R
K
G
K
H
P
-----
V
G
S
L
P
G
E
E
Y
L
V
A
G
S
D
K
---
G
Q
R
-----
G
Y
T
F
M
W
E
V
Q
-
G
K
E
------
E
S
L
T
E
P
N
L
T
A
G
L
A
V
L
E
R
S
N
E
N
G
K
P
P
P
P
A
F
K
S
D
-------------------
K
E
A
L
E
L
W
D
T
I
V
D
S
I
R
V
R
P
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
29.89
21%
268
- C5 -
2LQ2
-
?
A:
[1-30]
--------------V
K
G
R
I
D
A
P
D
F
P
S
S
P
A
I
L
G
K
A
A
T
D
V
V
A
A
W
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
26.56
25%
513
- C1 -
1PJM
-
RB_HUMAN
A:
[1-20]
----------------
C
G
K
R
S
A
E
G
S
N
P
P
K
P
L
K
K
L
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
23.01
9%
-53
- C5 -
2I68
-
EMRE_ECOLI
A:
[38-104]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Y
C
A
-------------------------
S
F
W
L
L
A
Q
T
L
A
-----
I
A
Y
-
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
------
A
I
I
G
M
M
---
L
I
C
--
A
G
V
L
I
I
N
L
L
------------------------------------------------------------------------------------------------------
19
Fugue
22.65
22%
227
- C5 -
2ROD
-
APR_MOUSE
B:
[17-43]
--------------------------------
A
E
L
P
P
E
F
A
A
Q
L
R
K
I
G
D
K
V
Y
C
T
W
S
A
P
D
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
15.21
19%
166
- C5 -
3RKO
-
?
J:
[133-160]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
P
Y
V
L
A
V
E
L
A
S
M
L
---
L
L
A
GL
V
V
A
F
H
V
G
R
E
E
R
----------------
A
G
E
V
L
-------------------------------------------------------------------------------
10
HHSearch
13.32
5%
258
- C5 -
3GIA
3
Y609_METJA
A:
[402-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
G
I
I
---
A
T
F
--
I
G
V
L
I
F
E
I
I
Y
R
----------------
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------
8
HHSearch
12.87
19%
225
- C5 -
2JP3
-
FXYD4_RAT
A:
[23-43]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
G
G
L
---
L
C
I
--
A
G
I
A
L
A
L
S
G
K
C
----------------
K
C
R
R
N
H
T
P
S
S
L
P
E
K
V
T
P
L
I
T
P
G
S
-
A
S
T
---------------------------------------------------------
9
HHSearch
11.93
11%
237
- C5 -
2JO1
-
PLM_HUMAN
A:
[22-39]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
A
G
I
---
L
F
I
--
L
G
I
L
I
V
L
S
R
R
C
----------------
R
C
K
F
N
Q
Q
Q
R
T
G
E
P
D
E
E
E
G
T
F
R
S
S
-
I
R
R
L
S
T
R
R
R
---------------------------------------------------