@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S39A4_HUMAN: (2015-12-10 )
MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKTACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGALTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
Atome Classification :
(20 SA)
----------------------.........10.....------...20........30.-.......40........50........60........70........80........90........100.....-..110......-.120.......130.---......140.......150-....---.....160.......170.......-180.-......190.....--..200--------.....--...210...---..----.-.220....--...230.......240.......250-.......260.......270.......280.....----..290.......300...-....310.......320.......330----....-----------...340.......350.......360.......370.......380.......390.......400....--...410.---......420.......-430.......440.......450.......460.......470...--....480.......490----.......500.......510.......520.---......530.......540.---..-....550---.......-560.......570.-----......580.......590.......600.......610.......620.......630......-.640.....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MA
S
L
V
S
L
E
L
G
L
L
L
A
V
L
------
V
V
TATASP
P
A
G
L
L
S
L
L
-TSGQGA
L
D
Q
E
A
L
G
G
L
L
N
T
L
A
D
R
VHCANGPCGKCL
S
V
E
D
ALGLGEPEGSGLPPG
P
V
L
E
A
R
Y
V
A
R
LS
A
A
A
V
L
Y
LSNP-EG
T
C
E
D
A
R
AGL-
W
A
S
H
A
D
H
L
L
A
L
L
ESP---KAL
T
P
G
L
S
W
L
L
Q
R
M
Q
A
R
---AAGQ---TPK
T
A
CV
D
I
P
Q
L
L
E
E
A
VGAGAPGSA-
G
G
V
L
-
A
A
L
L
D
H
VRSGSCFH--ALP
S
---------
P
Q
Y
F
V
--
D
F
V
F
Q
Q
HSS---EV----
P
-
M
T
L
A
E
L
S
A
--
L
M
Q
R
LGVGREAHSDH
S
H
RHRGASSRD-P
V
P
L
ISSSNSSS
V
W
D
T
V
C
L
S
A
R
D
V
M
A
AYGLSEQAG----V
T
P
E
A
W
A
QL
S
P
A
L
L
Q
Q
Q
L
-
S
GACTSQSRP
P
V
Q
D
Q
L
S
Q
S
E
R
Y
L
Y
G
S
L
----
A
T
L
L
-----------
I
C
L
C
A
V
F
G
L
L
L
L
TCTGC
R
G
V
T
H
Y
I
L
Q
T
F
L
S
L
A
V
G
ALTG
D
A
V
L
H
LT
P
K
V
L
G
L
HTHSEEGLSP
Q
P
T
W
R
L
L
A
M
--
L
A
G
L
Y
A
F
---
F
L
F
E
N
L
F
N
L
LLPR
D
P
E
-DLEDGPCGHSSHSHGGHSH
G
V
S
L
Q
LA
P
S
E
LRQPKPPHEGSRADLVA--EESPELLNPEPRRLSPE----L
R
L
L
P
Y
M
I
T
L
G
D
A
V
H
N
F
AD
G
L
A
V
G
A
A
F
A
S
S
W
---KT
G
L
A
T
S
L
A
V
F
C
H
E
L
P
H
E
L
G
---
D
F
-
A
A
L
L
H
A
G
---
L
S
V
R
Q
A
L
-
L
L
N
L
A
S
A
L
T
A
F
A
G
L
-----
Y
V
A
L
AVGVSEES
E
A
W
I
L
A
V
A
T
G
L
F
L
Y
V
A
L
C
D
M
L
P
A
M
L
KVRDPR
P
W
L
L
F
L
L
H
NVGL
L
G
G
W
T
V
L
L
L
L
-
S
L
Y
EDDITF---
26
Fugue
83.97
14%
-72
- C3 -
4BHW
1
EP300_HUMAN
A:
[14-576]
----------------------
K
K
I
F
K
P
E
E
L
R
Q
A
L
M
P
T
------
L
E
A
L
Y
R
Q
D
P
E
S
L
P
F
R
Q
-
P
V
D
P
Q
L
L
G
I
P
D
Y
F
D
I
V
K
S
P
M
D
-----------
L
S
T
I
K
R
K
L
D
T
G
Q
Y
Q
E
------
P
W
Q
Y
V
D
D
I
W
L
M
F
N
N
A
W
L
Y
N
R
K
T
-
S
------
R
V
Y
K
-
Y
C
S
K
L
S
E
V
F
E
Q
E
I
D
P
---
V
M
Q
S
L
G
Y
------
C
C
G
R
---
K
L
E
F
---
S
P
Q
T
L
C
C
Y
G
K
Q
L
-----------------------
C
T
I
P
R
D
A
T
Y
Y
--
S
Y
Q
N
---------
R
Y
H
F
C
--
E
K
C
F
N
E
I
Q
G
---
E
-----------
S
V
S
---
L
G
D
D
P
S
Q
P
Q
T
T
I
N
K
E
Q
F
S
K
R
K
N
D
T
L
D
-
P
E
L
F
V
E
C
T
E
C
G
R
K
M
H
Q
I
C
V
L
H
H
E
I
I
W
P
A
G
F
V
C
D
G
C
----
L
K
K
S
A
R
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
R
L
G
T
F
L
E
N
R
V
N
D
F
L
R
R
Q
N
H
P
E
S
G
E
V
----
T
V
R
V
-----------
V
H
A
S
D
K
T
V
E
V
K
P
G
M
K
A
R
F
V
D
S
G
E
M
A
E
S
F
P
Y
R
T
K
A
L
F
A
F
E
E
I
D
G
V
D
L
C
F
F
G
M
H
V
Q
E
Y
G
S
D
C
P
P
P
N
Q
R
R
V
Y
I
S
Y
L
D
S
V
H
F
F
RPK
C
L
R
T
A
V
Y
H
E
I
L
I
G
Y
L
E
-
Y
V
K
K
L
----------
G
Y
T
T
G
H
I
W
---------
A
C
P
P
S
E
G
D
D
Y
-
I
F
H
--
C
H
P
P
D
Q
K
I
P
K
P
K
R
L
Q
E
W
----
F
K
K
M
L
D
K
A
V
S
E
R
I
V
H
D
Y
K
D
------
I
F
K
Q
A
T
---
E
D
R
L
T
S
-----
A
K
E
L
P
Y
F
E
G
---
D
F
W
P
N
V
L
E
E
S
---
I
K
E
S
G
G
S
G
S
Q
K
L
Y
A
T
M
E
K
H
K
E
V
-----
F
F
V
I
R
L
I
A
G
P
A
A
N
S
L
P
P
I
V
D
P
D
P
L
I
P
C
D
L
M
D
G
R
D
A
F
L
T
L
A
R
D
K
----
H
L
E
F
S
S
L
R
R
A
Q
W
S
T
M
C
M
L
-
V
E
L
H
T
Q
S
Q
D
---
25
Fugue
83.61
16%
-71
- C1 -
4XR7
-
PAN2_YEAST
A:
[1-758]
MLAYPDYFNDITSDGPISVDDE
T
Y
P
L
S
S
V
G
M
P
Y
Y
L
D
K
L
LSAW
P
P
V
V
F
K
S
E
G
T
I
P
Q
L
L
A
V
I
-
S
S
Q
N
E
K
L
S
T
Q
E
F
P
L
L
R
Y
D
R
T
K
Y
G
M
R
N
A
I
P
D
Y
V
C
L
R
D
I
R
K
Q
I
T
S
G
L
E
T
S
D
I
Q
T
Y
T
S
I
N
K
Y
E
V
P
--
P
A
Y
S
R
L
P
L
T
F
D
F
T
P
F
N
N
T
E
Y
S
G
L
D
P
D
V
D
N
H
Y
T
N
A
I
I
Q
L
Y
---
R
F
I
P
E
M
F
N
F
V
V
G
C
L
K
D
E
---
N
F
E
T
---
T
L
L
T
D
L
G
Y
L
F
D
M
M
E
R
S
H
G
K
I
C
S
S
S
N
F
Q
A
S
L
-
K
S
L
T
D
K
L
E
S
L
C
I
R
E
--
S
I
E
D
SSESIKRN
M
P
Q
K
F
N
--
R
F
L
L
S
Q
L
I
K
---
E
E
----
A
-
Q
T
V
N
H
N
I
T
--
L
N
Q
C
F
G
L
E
T
E
I
R
T
E
C
S
C
D
H
Y
D
T
T
V
K
L
L
P
S
L
S
I
S
G
I
N
K
Q
N
I
L
P
Y
I
E
Y
A
M
K
N
V
T
Q
K
N
S
I
C
P
T
C
G
KT
E
T
I
T
Q
E
C
T
V
K
N
L
P
S
V
L
S
L
E
L
-
S
--
L
L
D
T
E
F
S
N
I
R
S
S
K
N
W
L
T
S
E
F
Y
G
S
I
I
KN
K
A
V
L
R
STASELKGT
S
H
I
F
K
Y
E
L
N
G
-
Y
V
A
K
I
T
D
N
N
N
E
T
R
L
V
--
T
Y
V
K
K
Y
N
P
K
E
N
C
F
K
W
L
M
F
N
D
-
Y
L
V
V
E
I
T
E
E
E
A
L
K
M
T
Y
P
W
K
T
P
E
I
--
I
I
Y
C
D
A
E
---
E
L
R
K
P
F
F
S
V
D
T
Y
S
I
N
Y
-
D
I
L
F
R
D
--
Y
F
A
N
A
R
R
E
Y
------
K
L
L
T
H
D
E
A
P
K
S
G
T
L
V
A
I
D
A
E
F
V
S
--
L
Q
S
E
L
C
E
I
D
H
Q
G
I
R
S
I
I
R
P
K
R
T
A
L
A
R
I
S
I
I
R
G
E
------
E
G
E
L
Y
G
V
P
F
V
D
D
Y
V
V
N
T
N
H
I
E
D
Y
L
T
R
Y
S
G
I
L
P
G
D
L
D
PEK
S
T
-
K
R
L
V
R
R
N
---
V
V
Y
R
K
V
W
-
L
L
M
Q
L
G
C
V
F
V
G
H
G
L
N
N
D
F
K
H
I
N
I
N
V
P
R
N
Q
I
R
D
T
A
I
Y
F
L
Q
G
K
R
Y
L
S
L
R
Y
L
A
Y
V
L
L
G
M
N
I
Q
E
G
N
H
D
S
I
E
D
A
H
T
A
L
I
L
Y
K
K
Y
L
H
L
K
E
K
A
I
F
E
K
V
L
N
S
---
29
Fugue
79.61
11%
-72
- C3 -
3O4Z
-
TEL2_YEAST
A:
[1-688]
--------------------------------
M
V
L
E
T
L
------
K
Q
G
L
D
S
S
Q
I
H
E
A
L
I
Q
L
D
S
Y
P
R
E
P
V
D
L
D
A
S
M
V
L
I
K
F
V
----------------
I
P
V
Y
P
S
L
P
E
R
S
K
V
I
L
R
R
L
A
S
K
S
F
T
F
L
C
Q
I
V
T
F
S
R
T
I
G
L
Q
E
-
I
R
I
Y
Q
E
I
L
E
D
I
-
I
S
F
E
P
G
C
L
T
F
Y
L
K
A
S
TTS
K
A
D
R
D
S
I
K
A
L
F
F
G
S
K
L
F
---
N
V
L
A
NRI
D
M
A
K
Y
L
G
Y
L
R
L
Q
W
K
F
L
L
E
S
N
E
T
D
P
P
-
G
F
L
G
-
E
W
L
V
S
S
F
L
L
N
-------------------
P
V
L
A
A
--
D
M
L
L
G
E
L
F
L
---
L
K
----
E
-
S
Y
F
F
S
F
Q
K
--
I
I
S
A
S
-------------
S
L
I
D
Q
K
R
L
-
I
A
K
F
L
L
P
Y
I
Q
V
I
V
T
L
E
N
L
N
D
V
R
K
I
L
R
R
F
D
L
D
K
I
------
I
S
L
S
V
L
F
E
I
Q
S
L
P
L
K
E
V
I
-
V
R
L
M
S
N
H
S
S
T
K
F
V
S
A
L
V
S
K
F
A
D
F
T
D
--------------------------------------
E
E
V
D
T
K
T
C
E
L
L
V
L
F
A
V
H
N
L
N
H
S
Q
R
E
E
I
A
H
D
E
R
F
L
N
G
V
T
K
H
L
G
S
N
E
R
E
A
R
E
R
A
M
--
F
I
A
K
L
L
S
---
G
G
H
L
K
Y
E
S
D
F
K
I
N
I
P
N
V
K
S
D
D
K
I
I
D
F
Q
S
L
K
R
E
I
V
K
R
I
V
F
L
K
D
L
M
K
E
Y
E
K
S
R
K
A
P
L
----
I
P
L
L
--
K
Q
T
V
K
L
I
R
Q
K
A
F
Q
L
E
V
G
----
Y
Y
A
Q
G
I
L
S
S
I
V
C
L
N
N
E
F
D
E
---------
P
L
F
---
E
Q
W
R
I
N
A
L
T
S
I
L
V
V
L
P
E
K
V
N
---
G
A
-
I
N
I
L
F
N
S
E
L
S
L
Q
Q
R
M
S
L
-
L
S
A
L
G
L
S
A
R
E
L
R
G
L
-----
D
T
Q
N
R
F
R
K
Y
A
G
L
F
F
Y
P
L
A
H
G
W
L
N
G
I
Q
L
F
K
S
H
Y
L
T
T
L
R
I
I
Y
S
C
A
N
----
P
V
H
D
F
E
S
M
T
E
L
M
N
H
I
I
S
-
S
A
I
E
E
G
I
S
L
NKG
4
PsiBlast_PDB
36.43
37%
111
- C2 -
3CQ6
-
HIS8_CORGL
A:
[22-75]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
Y
G
A
P
Q
L
N
V
D
I
R
L
N
T
N
E
--
N
P
Y
P
P
S
E
A
L
V
A
D
L
V
A
T
V
D
K
I
A
T
E
L
N
R
Y
P
E
R
D
A
V
E
----
L
R
D
E
L
A
A
Y
I
T
K
Q
T
G
V
A
V
T
R
D
N
L
W
A
A
N
G
S
N
E
I
---
L
Q
Q
L
L
Q
A
F
G
G
P
G
R
T
A
L
G
F
Q
P
---
S
Y
-
S
M
H
P
I
L
A
---
K
G
T
H
T
E
F
-
I
A
V
S
R
G
A
D
F
R
I
D
M
D
-----
V
A
L
E
E
I
R
A
K
Q
P
D
I
V
F
V
T
T
P
N
N
P
T
G
D
V
T
S
L
D
D
V
E
R
I
I
N
V
A
P
G
I
V
I
V
D
E
A
Y
A
E
F
S
P
S
P
S
A
T
T
L
L
E
K
Y
-
P
T
K
L
V
V
S
R
T
---
3
PsiBlast_PDB
34.17
37%
113
- C2 -
3CQ5
3
HIS8_CORGL
A:
[22-75]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
Y
G
A
P
Q
L
N
V
D
I
R
L
N
T
N
E
--
N
P
Y
P
P
S
E
A
L
V
A
D
L
V
A
T
V
D
K
I
A
T
E
L
N
R
Y
P
E
R
D
A
V
E
----
L
R
D
E
L
A
A
Y
I
T
K
Q
T
G
V
A
V
T
R
D
N
L
W
A
A
N
G
S
N
E
I
---
L
Q
Q
L
L
Q
A
F
G
G
P
G
R
T
A
L
G
F
Q
P
---
S
Y
-
S
M
H
P
I
L
A
---
K
G
T
H
T
E
F
-
I
A
V
S
R
G
A
D
F
R
I
D
M
D
-----
V
A
L
E
E
I
R
A
K
Q
P
D
I
V
F
V
T
T
P
N
N
P
T
G
D
V
T
S
L
D
D
V
E
R
I
I
N
V
A
P
G
I
V
I
V
D
E
A
Y
A
E
F
S
P
S
P
S
A
T
T
L
L
E
K
Y
-
P
T
K
L
V
V
S
R
T
---
10
PsiBlast_PDB
34.00
29%
16
* C4 *
1YKM
-
PCXB_PSEPU
B:
[17-112]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
K
A
L
T
P
D
Y
K
T
S
I
A
R
--------------
S
P
R
Q
A
L
V
S
I
P
Q
S
I
S
E
T
T
G
P
N
F
S
H
L
G
-
F
G
A
H
D
H
D
L
L
L
N
F
N
N
G
------
G
L
P
I
---------
G
E
R
I
I
V
A
G
R
V
V
D
Q
Y
G
K
---
P
V
----
P
-
N
T
L
V
E
-----
M
W
Q
A
N
A
G
G
R
E
R
H
K
N
D
R
Y
L
A
P
L
D
P
N
F
G
-
G
V
G
R
C
L
T
D
S
D
G
Y
Y
S
F
R
T
I
K
P
G
P
Y
P
W
R
N
G
P
N
D
W
R
P
A
----
H
I
H
F
G
I
S
G
P
S
I
A
T
K
L
I
T
Q
-
L
Y
F
E
G
D
P
L
I
P
M
C
P
I
V
K
S
I
A
N
P
E
A
V
Q
Q
L
----
I
A
K
L
-----------
D
M
N
N
A
N
P
M
D
C
L
A
Y
R
F
D
I
V
L
R
G
Q
R
K
T
H
F
E
N
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
33.29
20%
104
- C2 -
1DF4
-
?
A:
[3-64]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
V
Q
Q
Q
N
N
L
L
R
A
I
E
A
Q
---
Q
H
L
L
Q
L
T
V
W
G
I
K
Q
L
Q
A
G
GW
M
E
W
D
R
---
E
I
N
N
Y
T
S
L
I
H
S
L
I
E
E
S
Q
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
32.33
29%
20
- C4 -
1YKN
-
PCXB_PSEPU
B:
[17-112]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
K
A
L
T
P
D
Y
K
T
S
I
A
R
--------------
S
P
R
Q
A
L
V
S
I
P
Q
S
I
S
E
T
T
G
P
N
F
S
H
L
G
-
F
G
A
H
D
H
D
L
L
L
N
F
N
N
G
------
G
L
P
I
---------
G
E
R
I
I
V
A
G
R
V
V
D
Q
Y
G
K
---
P
V
----
P
-
N
T
L
V
E
-----
M
W
Q
A
N
A
G
G
R
E
R
H
K
N
D
R
Y
L
A
P
L
D
P
N
F
G
-
G
V
G
R
C
L
T
D
S
D
G
Y
Y
S
F
R
T
I
K
P
G
P
Y
P
W
R
N
G
P
N
D
W
R
P
A
----
H
I
H
F
G
I
S
G
P
S
I
A
T
K
L
I
T
Q
-
L
Y
F
E
G
D
P
L
I
P
M
C
P
I
V
K
S
I
A
N
P
E
A
V
Q
Q
L
----
I
A
K
L
-----------
D
M
N
N
A
N
P
M
D
C
L
A
Y
R
F
D
I
V
L
R
G
Q
R
K
T
H
F
E
N
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
29.94
39%
263
- C2 -
4GMF
-
?
A:
[297-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
W
L
L
H
Q
L
R
S
H
---
L
A
G
E
---
H
P
P
V
A
C
Q
N
V
H
Q
I
A
L
S
R
L
W
Q
Q
I
L
R
K
T
-
G
N
A
E
-
I
R
R
L
T
P
P
H
H
D
R
L
A
G
--
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
28.41
30%
139
- C2 -
2L5V
-
ADRM1_HUMAN
A:
[267-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
S
I
L
A
T
M
N
V
P
A
G
P
A
G
G
Q
Q
V
D
L
A
S
--
V
L
T
P
E
I
M
A
P
I
L
A
N
A
D
V
Q
----
E
R
L
L
P
Y
L
P
S
-
G
E
S
L
P
Q
T
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
28.18
39%
264
- C2 -
4GMG
-
?
A:
[317-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
W
L
L
H
Q
L
R
S
H
---
L
A
G
E
---
H
P
P
V
A
C
Q
N
V
H
Q
I
A
L
S
R
L
W
Q
Q
I
L
R
K
T
-
G
N
A
E
-
I
R
R
L
T
P
P
H
H
D
R
L
A
G
--
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
26.19
30%
134
- C2 -
2KQZ
-
ADRM1_HUMAN
A:
[267-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
S
I
L
A
T
M
N
V
P
A
G
P
A
G
G
Q
Q
V
D
L
A
S
--
V
L
T
P
E
I
M
A
P
I
L
A
N
A
D
V
Q
----
E
R
L
L
P
Y
L
P
S
-
G
E
S
L
P
Q
T
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
25.89
23%
74
* C3 *
1HA8
-
MER23_EUPRA
A:
[1-51]
----------------------------------------------------------------------------------------
G
E
C
E
Q
C
F
S
D
G
G
D
C
T
T
C
F
N
N
G
T
G
-
P
C
A
N
C
L
A
G
Y
P
A
G
C
S
N
S
D
C
T
A
F
L
S
Q
C
-
Y
G
G
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
25.48
24%
152
- C2 -
1UHK
1
AEQ2_AEQVI
A:
[110-140]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
--
D
A
L
F
D
I
V
D
K
DQ-
N
G
----
A
-
I
T
L
D
E
W
K
A
--
Y
T
K
A
A
G
I
I
Q
S
S
E
D
C
E
E
T
F
R
V
C
D
I
D
E
S
-
G
Q
L
D
V
D
E
M
T
R
Q
H
L
G
F
W
Y
T
M
D
P
A
C
E
K
L
Y
G
G
A
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
24.96
19%
67
- C2 -
3BQ3
1
DCN1_YEAST
A:
[70-106]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
---------
Y
P
K
E
L
--
T
Q
V
F
E
H
Y
I
N
---
N
N
----
L
-
F
D
I
D
S
L
V
K
--
F
I
E
E
L
G
Y
N
L
E
D
L
A
T
L
C
L
A
H
L
L
G
Y
K
K
L
-
E
E
P
L
K
R
E
D
F
L
S
T
W
F
M
Q
G
C
S
T
I
S
D
M
Q
E
C
I
K
T
L
D
V
K
L
----
H
E
D
L
Q
Y
F
T
Q
I
Y
N
Y
A
F
N
L
I
-
L
D
P
N
R
K
D
I
D
T
D
E
G
I
Q
Y
W
K
L
F
F
Q
P
E
Y
P
V
----
R
M
E
P
-----------
D
L
L
E
A
W
F
R
F
L
R
D
E
G
K
T
T
I
S
K
D
T
W
R
M
L
L
L
F
F
K
R
Y
P
T
I
Q
K
I
I
S
D
Y
D
E
T
A
A
W
P
F
I
I
D
E
F
Y
E
C
L
Q
D
Q
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
24.47
17%
-2
- C2 -
2UVP
-
?
A:
[40-100]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
L
I
-
A
Q
T
I
S
H
V
L
N
G
G
S
L
L
V
S
A
D
S
S
---------
R
H
W
F
L
--
N
Y
I
L
S
N
L
N
P
---
K
D
LKER
P
L
L
S
V
I
D
F
N
A
SS
F
Y
P
K
N
D
A
N
L
S
L
A
T
I
E
M
T
Y
Q
N
P
M
F
W
H
V
-
G
K
I
E
N
E
G
L
K
T
I
L
L
S
K
I
P
S
F
L
W
L
F
E
E
L
K
E
D
C
L
L
L
K
E
----
H
D
S
L
L
D
Y
K
L
L
Q
L
F
K
L
F
E
N
-
A
L
F
S
V
L
Y
N
K
V
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
23.62
30%
109
- C2 -
2KR0
-
ADRM1_HUMAN
A:
[267-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
S
I
L
A
T
M
N
V
P
A
G
P
A
G
G
Q
Q
V
D
L
A
S
--
V
L
T
P
E
I
M
A
P
I
L
A
N
A
D
V
Q
----
E
R
L
L
P
Y
L
P
S
-
G
E
S
L
P
Q
T
A
D
E
I
Q
N
T
L
T
S
P
Q
F
Q
---
Q
A
L
G
M
F
S
A
A
L
A
S
G
Q
L
G
P
L
M
C
---
Q
F
-
G
L
P
A
E
A
V
---
E
A
A
N
K
G
D
-
V
E
A
F
A
K
A
M
Q
N
N
A
K
P
-----
E
Q
K
E
G
D
T
K
D
K
K
D
E
E
E
D
M
S
L
D
----------------------------------------------------------
17
HHSearch
23.57
6%
113
- C2 -
3TDU
1
CUL1_HUMAN (first)
A:
[6-39]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
E
Q
L
Y
N
R
Y
K
D
PQD
E
N
----
K
-
I
G
I
D
G
I
Q
Q
--
F
C
D
D
L
A
L
D
P
A
S
I
S
V
L
I
I
A
W
K
F
R
A
A
T
Q
-
C
E
F
S
K
Q
E
F
M
D
G
M
T
E
L
G
C
D
S
I
E
K
L
K
A
Q
I
P
K
M
E
Q
E
L
K
----
E
P
G
R
F
K
D
F
Y
Q
F
T
F
N
F
A
K
N
-
P
G
Q
K
G
L
D
L
E
M
A
I
A
Y
W
N
L
V
L
N
G
R
F
K
F
L
D
----
L
W
N
K
-----------
F
L
L
E
H
H
K
R
S
I
P
K
D
T
W
N
L
L
L
D
F
S
T
M
I
A
D
D
M
S
N
Y
D
E
E
G
A
W
P
V
L
I
D
D
F
V
E
F
A
R
P
Q
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
23.09
26%
-11
- C2 -
4PBU
-
PSBT_THEEB
T:
[1-30]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
I
T
Y
V
F
I
--
F
A
C
I
I
A
L
---
F
F
F
A
I
F
F
-----
R
E
P
P
-
R
I
T
A
N
L
W
E
R
F
C
N
W
V
T
S
T
D
N
R
L
Y
V
G
W
F
G
V
I
M
I
P
T
L
L
A
A
T
I
C
F
V
I
A
F
I
--
A
A
P
P
V
D
I
D
G
I
R
E
P
V
S
G
S
----
L
L
Y
G
N
N
I
I
T
G
A
V
V
P
S
S
N
A
I
G
L
H
F
Y
P
I
W
E
A
A
S
---
L
D
E
W
L
Y
N
G
G
P
Y
Q
L
I
I
F
H
F
L
L
---
G
A
-
S
C
Y
M
G
R
Q
---
W
E
L
S
Y
R
L
-
G
M
R
P
W
I
C
V
A
Y
S
A
P
L
-----
A
S
A
F
A
V
F
L
I
Y
P
I
G
Q
G
S
F
S
D
G
M
P
L
G
I
S
G
T
F
N
F
M
I
V
F
Q
A
E
H
N
I
L
M
H
P
F
H
Q
L
G
V
A
G
V
F
G
G
A
L
F
C
A
M
H
G
-
S
L
V
T
S
S
L
I
R
---
22
Fugue
22.77
25%
-8
- C2 -
1S5L
-
PSBT_THEEB
T:
[1-31]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
I
T
Y
V
F
I
--
F
A
C
I
I
A
L
---
F
F
F
A
I
F
F
-----
R
E
P
P
-
R
I
T
K
N
L
W
E
R
F
C
N
W
V
T
S
T
D
N
R
L
Y
V
G
W
F
G
V
I
M
I
P
T
L
L
A
A
T
I
C
F
V
I
A
F
I
--
A
A
P
P
V
D
I
D
G
I
R
E
P
V
S
G
S
----
L
L
Y
G
N
N
I
I
T
G
A
V
V
P
S
S
N
A
I
G
L
H
F
Y
P
I
W
E
A
A
S
---
L
D
E
W
L
Y
N
G
G
P
Y
Q
L
I
I
F
H
F
L
L
---
G
A
-
S
C
Y
M
G
R
Q
---
W
E
L
S
Y
R
L
-
G
M
R
P
W
I
C
V
A
Y
S
A
P
L
-----
A
S
A
F
A
V
F
L
I
Y
P
I
G
Q
G
S
F
S
D
G
M
P
L
G
I
S
G
T
F
N
F
M
I
V
F
Q
A
E
H
N
I
L
M
H
P
F
H
Q
L
G
V
A
G
V
F
G
G
A
L
F
C
A
M
H
G
-
S
L
V
T
S
S
L
I
R
---