@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S45A3_HUMAN: (2015-12-11 )
MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLSPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDLAILDSAFLLSQVAPSLFMGSIVQLSQSVTAYMVSAAGLGLVAIYFATQVVFDKSDLAKYSA
Atome Classification :
(20 SA)
---.........10...----.....20.--......-----.30........40....-.-...50........60........70........80........90--...--.....100.......110.......120.......130...----....140.......150-........160..-......170.-......180.......190.......200.......210.......220.......230.......240.......250.....------..260.......270.......280.......290.......300........310.......320.......330.......340.......350.......360.......370---.......380.....----------..390.......400.......---410.......420.......430.......440.......450...----....460.......470.---......480.......--490.......500.......510....--...520-----.......530.......540.......550.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
V
Q
R
L
W
V
S
R
L
L
R
H
R
----
K
A
Q
L
L
L
V
N
--
L
L
T
F
G
L
-----
E
V
C
L
AAG
I
T
YV
P
P
L
L
L
E-V-GV
E
E
K
F
M
T
M
V
L
G
I
G
P
V
L
G
L
V
C
V
P
LLGSASDHWRGRYGRRR
P
F
I
W
A
--
L
S
L
--
G
I
L
L
S
L
F
L
IPRAG
W
L
A
GLLCPDPR
P
L
E
L
A
L
L
I
L
G
V
G
L
L
D
F
C
----
G
Q
V
C
F
T
P
L
E
A
L
L
S
D
L
F--RD
P
D
H
C
R
Q
A
-
Y
S
V
-
Y
A
F
M
I
S
L
G
G
C
-
L
G
Y
L
L
PAIDWDTSALAPYLG
T
Q
E
E
C
L
F
G
L
L
T
L
I
F
L
T
C
V
A
A
T
L
L
V
A
E
EAALGPTEPAEGLSAPSLSPHCC
P
C
R
A
R
L
A
F
R
N
L
G
A
L
L
------
P
R
L
H
Q
L
C
C
R
M
P
R
T
L
R
R
L
F
V
A
E
L
C
S
W
M
A
L
M
T
F
T
L
F
Y
T
D
F
V
G
E
G
L
Y-QGVPRAEPG
T
E
A
R
R
H
Y
D
EGVRMG
S
L
G
L
F
L
Q
C
A
I
S
L
V
F
S
L
V
M
D
R
L
V
Q
R
FGT
R
A
V
Y
L
A
S
V
A
AFPVAA
G
A
T
C
LS---H
S
V
A
V
V
T
A
S
A
A
LT
G
F
----------
T
F
S
A
L
Q
I
L
P
Y
T
L
A
S
L
Y
H
R
E
K
Q
V
---
F
L
PKYRGDTGGASS
E
D
S
L
M
T
S
FLPGPKPGAPFPNGHVGAGGSGLLP----P
P
P
A
LCGASAC
D
V
S
V
R
V
V
---VGEPTE
A
R
VVPGR
G
I
C
--
L
D
L
A
I
L
D
S
A
F
L
L
S
Q
V
A
P
S
L
F
M
G
S
I
V
Q
L
--
S
Q
S
V
T
A
-----
Y
M
V
S
A
A
G
L
G
L
V
A
I
Y
F
A
T
Q
V
VF
D
K
S
D
L
AKYSA-----
23
Fugue
82.37
18%
-115
- C1 -
3WDO
-
?
A:
[1-453]
-----
D
Y
K
M
T
P
G
E
R
R
A
T
----
W
G
L
G
T
V
F
S
--
L
R
M
L
G
M
-----
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
----
Q
-
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
----
I
G
R
K
P
L
I
V
G
G
--
L
A
V
--
F
A
A
G
S
V
I
A
A
L
S
---------
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
I
-----------
A
A
A
V
M
A
L
L
S
D
L
T
--
R
-------
E
-
Q
N
R
-
T
K
A
M
A
F
I
G
V
S
-
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
--
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
----------------
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
------
A
E
--------
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
------------
A
G
F
P
A
A
E
H
W
K
--
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
---------
Q
F
W
Q
L
V
V
G
V
Q
L
F
-----------
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
------
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
----------
F
D
----
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
---
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
--
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
--
E
E
E
H
S
A
-----
Y
V
K
I
D
S
K
---
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------
24
Fugue
74.99
17%
-104
- C1 -
4IKW
13
?
A:
[3-494]
---
S
I
D
K
Q
Q
I
A
A
S
V
P
Q
R
GFFG
H
P
K
G
L
F
T
L
--
F
F
T
E
F
W
-----
E
R
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
M
Y
-
Y
-
E
V
S
K
G
----
G
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
--
T
S
R
--
A
V
F
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
------
P
G
G
V
A
A
L
F
V
S
M
A
L
I
V
L
G
----
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
--
K
P
G
D
D
R
R
D
A
G
F
S
I
-
F
Y
M
G
I
N
L
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
-
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
---------------
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
-----------
P
K
T
T
--
A
E
E
R
S
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
Q
G
S
T
I
L
A
N
Y
A
D
K
R
-----------------------------
T
Q
L
D
V
A
G
I
H
L
S
P
A
----------
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
---
K
L
G
K
R
Q
P
T
----
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
L
V
P
G
H
L
S
G
G
G
---
L
V
----
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
LSP
V
G
L
S
A
T
T
K
L
A
P
----
A
--
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
YT
P
E
N
E
T
A
-----
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G
-------
22
Fugue
71.67
18%
-106
* C2 *
4TQT
6
?
A:
[14-490]
A
S
K
V
I
K
G
G
T
V
I
T
A
D
R
T
F
----
R
A
D
I
L
I
E
D
GK
I
A
A
I
G
D
S
L
E
G
D
E
V
I
D
A
S
G
C
Y
V
M
P
G
------------------
G
I
D
P
H
T
H
L
Q
-
M
P
F
M
G
T
Y
S
S
D
-----------------
D
F
--
D
T
G
T
A
A
A
L
A
G
G
T
T
M
V
V
D
F
V
L
P
D
S
E
G
--------------------------
N
L
L
D
A
L
Q
E
W
F
--
Q
K
A
G
K
A
R
----
T
D
-
Y
S
F
H
M
A
I
T
G
-----------
W
N
E
R
T
F
N
E
M
A
E
V
V
K
R
---
G
I
N
T
F
H
F
M
-
A
Y
K
G
A
L
M
V
N
D
D
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
---
M
P
L
V
H
A
E
N
G
D
I
V
A
Q
L
Q
A
K
L
M
A
E
GNDG
P
E
A
H
A
Y
S
--
R
P
P
E
V
E
G
E
A
T
N
R
A
I
M
I
A
D
Q
A
G
V
P
L
Y
V
V
H
V
S
C
E
Q
S
H
-
E
A
I
R
R
A
R
Q
---------
K
G
M
R
V
F
G
--------
E
P
L
I
Q
H
L
T
L
D
E
S
E
Y
H
N
R
D
W
D
Y
A
A
R
R
V
M
S
P
P
F
R
D
K
-------------
L
N
Q
D
S
L
W
A
G
L
----------
A
A
G
S
L
Q
C
V
A
T
D
H
C
A
F
T
T
E
Q
K
R
Y
GIG
N
F
T
K
I
P
N
G
T
G
G
L
--
E
E
R
M
P
V
L
W
T
R
G
V
R
T
G
R
L
T
P
N
E
F
V
A
V
T
S
T
N
I
A
K
I
L
NI
Y
P
Q
K
G
A
V
V
P
G
A
D
A
D
--
L
V
---
I
W
D
P
E
T
T
K
K
I
S
A
K
T
Q
H
SS
I
D
Y
N
V
F
E
G
F
E
L
K
G
L
P
I
M
T
L
S
R
G
R
I
A
F
D
--
K
G
Q
V
T
A
KPGD
G
R
F
I
E
R
E
P
N
G
A
V
N
R
A
L
S
Q
W
K
E
I
V
A
P
R
K
V
E
R
S
A
-----
18
Fugue
67.51
13%
-119
* C1 *
1PV6
-
LACY_ECOLI
A:
[1-417]
------------
M
Y
Y
L
K
----
N
T
N
F
W
M
F
G
--
L
F
F
F
F
Y
-----
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
-
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
-----
L
R
K
Y
L
L
W
--
I
I
T
--
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
P
L
L
Q
-----
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
----
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
--
R
R
S
N
---
F
E
-
F
G
R
-
A
R
M
F
G
C
V
G
W
A
-
L
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
----------------
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
------------------
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
---------------
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
----------
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
------------------
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
------------------------------------------------------------------------
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
--
I
G
F
Q
G
A
-----
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
19
Fugue
61.59
11%
-99
- C1 -
2XUT
-
?
A:
[13-500]
------------
Q
I
P
Y
I
----
I
A
S
E
A
C
E
R
--
F
S
F
Y
G
M
-----
R
N
I
L
T
P
F
L
M
T
A
L
L
L
S
I
P
-
E
-
E
L
R
G
A
V
A
K
D
V
F
H
S
F
V
I
G
V
Y
F
F
P
L
L
G
G
W
I
A
D
R
F
F
G
K
----
Y
N
T
I
L
W
--
L
S
L
--
I
Y
C
V
G
H
A
F
L
A
I
F
E
H
S
-----
V
Q
G
F
Y
T
G
L
F
L
I
A
L
G
S
G
G
I
-----------
K
P
L
V
S
S
F
M
G
D
Q
F
DQ
S
N
K
S
L
A
Q
K
A
-
F
D
M
-
F
Y
F
T
I
N
F
G
S
F
-
F
A
S
L
S
----------
M
P
L
L
L
K
N
F
G
A
A
V
A
F
G
I
P
G
V
L
M
F
V
A
T
V
F
F
W
L
G
R
K
R
Y
I
H
M
P
V
E
-------------
G
K
G
N
I
G
L
V
L
A
L
I
G
G
V
------
S
A
A
Y
A
L
V
N
I
P
T
L
G
I
V
A
G
L
C
C
A
M
V
L
V
M
G
F
V
G
A
G
A
S
L
Q
L
E
R
A
R
K
S
H
-
P
D
A
A
V
D
G
V
--
R
S
V
L
R
I
L
V
L
F
A
L
V
T
P
F
W
S
L
F
D
Q
K
A
S
T
W
I
L
Q
A
N
D
M
V
K
P
Q
W
F
E
P
A
M
M
Q
A
L
N
P
L
L
V
M
L
L
I
P
F
N
N
---
F
V
T
A
L
R
K
M
G
A
G
I
A
I
T
----------
G
L
S
W
I
V
V
G
T
------------------
I
Q
L
M
M
D
G
G
S
A
L
S
I
F
W
Q
I
L
P
Y
A
L
L
T
F
G
E
V
L
V
S
A
T
G
L
-------------------------------------
E
F
A
Y
S
Q
A
P
K
A
------
M
K
G
T
I
M
S
F
W
T
L
S
V
T
V
G
N
L
W
V
L
L
A
N
V
S
--
V
K
S
P
T
V
-----
T
E
Q
I
V
Q
T
G
M
S
V
T
A
F
Q
M
F
F
F
A
G
F
A
I
L
A
A
I
V
F
A
-----
12
HHSearch
50.14
14%
-122
- C1 -
2CFQ
-
LACY_ECOLI
A:
[7-311]
----------------------
T
N
F
W
M
F
G
--
L
F
F
F
F
Y
-----
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
-
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
----
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
--
V
M
F
A
P
F
F
I
F
I
F
G
P
L
------------
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
LGFC
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
-----
R
R
S
N
F
E
-
F
G
R
-
A
R
M
F
G
C
V
G
W
A
-
L
G
A
S
I
V
G
I
M
F
T
I
---------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
---------
A
F
S
L
K
L
A
L
E
L
---------------
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
--------------
R
V
F
G
Y
V
-
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
----------
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
---
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
----
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
---
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------
10
HHSearch
49.88
18%
-166
- C1 -
3WDO
-
?
A:
[10-188]
----------------------
R
A
T
W
G
L
G
--
T
V
F
S
L
R
-----
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
-
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
----
R
I
G
R
K
P
L
I
V
G
G
--
L
-
A
--
V
F
A
A
G
S
V
I
A
A
L
S
D
-------------
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
----
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
--
R
-
E
Q
N
R
T
K
A
-
M
A
F
-
I
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
--------
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
------
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
-
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
---
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
----------
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
---
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
----
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
---
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
--------------------------------------------------------------------------------
14
HHSearch
47.45
11%
-157
- C1 -
1PW4
-
GLPT_ECOLI
A:
[253-429]
----------------------
K
L
L
W
Y
I
A
--
I
A
N
V
F
V
-----
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
-
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
----
K
V
F
R
G
N
R
G
A
T
G
--
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
-----------
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
----
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
--
P
-
K
K
A
A
G
T
A
-
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
--------
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
43.21
18%
-144
- C1 -
2GFP
-
EMRD_ECOLI
A:
[18-174]
----------------------------------
A
V
G
-----
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
-
L
-
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
----
R
V
G
R
R
P
V
I
L
V
G
--
M
S
I
---
F
M
L
A
T
L
V
A
V
T
T
S
-------------
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
----
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
--
E
-
R
T
Q
L
R
H
A
-
N
S
L
-
L
N
M
G
I
L
V
S
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
--------
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
------
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
-
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
---
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
----------
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
---
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
42.13
11%
-134
- C1 -
1PW4
-
GLPT_ECOLI
A:
[49-320]
-------------------------------------------------
A
L
A
M
P
-
Y
L
V
E
-
Q
-
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
----
R
S
N
P
R
V
F
L
P
A
G
---
L
I
--
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
---------
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
----
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
--
S
-
Q
K
E
R
G
G
I
-
V
S
V
-
W
N
C
A
H
N
V
G
G
G
-
I
P
P
L
L
F
L
L
G
M
A
W
------
F
-
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
---------------
T
A
K
Q
I
F
------
M
---
Q
Y
-
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
---
H
F
A
L
--------------
D
K
S
S
W
A
-
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
---
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
----------
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
---
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
----
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
---
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------
13
HHSearch
38.04
18%
-95
- C1 -
3WDO
-
?
A:
[47-170]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
I
A
-
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
----------
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
-----------------------------------------------------------------------------------------
R
T
--
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
--
L
G
L
H
A
L
-----
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
-----
9
HHSearch
36.65
10%
-134
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[35-176]
---------------------------------
F
F
L
W
-----
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
-
F
-
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
----
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
--
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
----------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
----
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
--
P
-
E
S
S
G
H
F
R
-
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
------
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
-
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
---
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
----------
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
---
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
35.43
19%
-94
- C1 -
2GFP
-
EMRD_ECOLI
A:
[44-167]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
S
V
-
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
----------
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
-----------------------------------------------------------------------------------------
L
R
--
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
--
W
N
W
R
A
C
-----
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
-----
15
HHSearch
34.74
7%
-103
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[62-149]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
G
L
I
-
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
----------
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
---
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
----
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
---
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
--
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
--
H
W
R
W
A
V
-----
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
-----
17
HHSearch
32.91
13%
-121
- C1 -
2CFQ
-
LACY_ECOLI
A:
[257-395]
----------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
----
R
I
G
G
K
N
A
L
L
L
A
--
G
T
I
---
M
S
V
R
I
I
G
S
S
F
A
T
S
-------------
A
L
E
V
V
I
L
K
T
L
H
M
F
E
----
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
--
E
-
V
R
F
S
A
T
I
-
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
--------
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
28.73
26%
9
- C3 -
1YC0
-
A:
[70-161]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
S
A
A
H
C
F
S
---
H
S
P
P
R
D
S
V
S
V
V
L
G
Q
H
FFNRTTDV
T
Q
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
S
D
H
D
---
L
V
L
I
R
L
K
K
K
G
D
R
C
A
T
R
S
Q
F
V
Q
P
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Q
I
A
G
W
G
H
L
----
D
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
L
---
V
A
D
H
K
C
S
S
P
E
V
Y
G
A
D
I
--
S
P
N
M
L
C
A
G
Y
F
D
C
K
S
D
A
C
Q
G
D
S
G
G
P
L
A
C
--
E
K
N
G
V
A
-----
Y
L
Y
G
I
I
S
W
G
D
G
C
G
R
L
H
K
P
G
V
Y
T
R
V
A
N
Y
V
D
W
I
-----
4
PsiBlast_PDB
28.72
26%
15
- C3 -
2R0L
2
A:
[35-126]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
S
A
A
H
C
F
S
---
H
S
P
P
R
D
S
V
S
V
V
L
G
Q
H
FFNRTTDV
T
Q
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
S
D
H
D
---
L
V
L
I
R
L
K
K
K
G
D
R
C
A
T
R
S
Q
F
V
Q
P
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Q
I
A
G
W
G
H
L
----
D
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
L
---
V
A
D
H
K
C
S
S
P
E
V
Y
G
A
D
I
--
S
P
N
M
L
C
A
G
Y
F
D
C
K
S
D
A
C
Q
G
D
S
G
G
P
L
A
C
--
E
K
N
G
V
A
-----
Y
L
Y
G
I
I
S
W
G
D
G
C
G
R
L
H
K
P
G
V
Y
T
R
V
A
N
Y
V
D
W
I
-----
6
PsiBlast_PDB
28.09
26%
4
* C3 *
2WUC
3
HGFA_HUMAN
A:
[35-126]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
S
A
A
H
C
F
S
---
H
S
P
P
R
D
S
V
S
V
V
L
G
Q
H
FFNRTTDV
T
Q
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
S
D
H
D
---
L
V
L
I
R
L
K
K
K
G
D
R
C
A
T
R
S
Q
F
V
Q
P
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Q
I
A
G
W
G
H
L
----
D
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
L
---
V
A
D
H
K
C
S
S
P
E
V
Y
G
A
D
I
--
S
P
N
M
L
C
A
G
Y
F
D
C
K
S
D
A
C
Q
G
D
S
G
G
P
L
A
C
--
E
K
N
G
V
A
-----
Y
L
Y
G
I
I
S
W
G
D
G
C
G
R
L
H
K
P
G
V
Y
T
R
V
A
N
Y
V
D
W
I
-----
5
PsiBlast_PDB
27.47
26%
7
- C3 -
2WUB
2
?
A:
[35-126]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
S
A
A
H
C
F
S
---
H
S
P
P
R
D
S
V
S
V
V
L
G
Q
H
FFNRTTDV
T
Q
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
S
D
H
D
---
L
V
L
I
R
L
K
K
K
G
D
R
C
A
T
R
S
Q
F
V
Q
P
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Q
I
A
G
W
G
H
L
----
D
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
L
---
V
A
D
H
K
C
S
S
P
E
V
Y
G
A
D
I
--
S
P
N
M
L
C
A
G
Y
F
D
C
A
C
Q
G
D
S
G
G
P
L
A
C
E
K
N
--
G
V
A
Y
L
Y
-----
G
I
I
S
W
G
C
G
K
P
G
V
Y
T
R
V
A
N
Y
V
D
W
I
N
D
R
I
R
P
-------
3
PsiBlast_PDB
27.15
26%
14
- C3 -
2R0K
-
A:
[52-134]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
S
A
A
H
C
F
S
-------
R
D
S
V
S
V
V
L
G
Q
H
FFNRTTDVTQ
T
F
G
I
E
K
Y
I
P
Y
T
L
Y
S
V
F
N
P
-
D
H
D
---
L
V
L
I
R
L
K
K
K
----
A
T
R
S
Q
F
V
Q
P
I
C
L
P
E
P
G
S
T
F
P
A
G
H
K
C
Q
I
A
G
W
G
H
L
----
D
E
N
V
S
G
Y
S
S
S
L
R
E
A
L
V
P
L
---
V
A
D
H
K
C
S
S
V
Y
G
A
D
I
S
P
--
N
M
L
C
A
G
F
D
C
K
D
A
C
Q
G
D
S
G
G
P
L
A
C
E
K
N
G
--
V
A
Y
L
Y
G
-----
I
I
S
W
G
D
G
C
G
L
H
K
P
G
V
Y
T
R
V
A
N
Y
V
D
W
I
N
D
R
I
R
-----