@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A7_HUMAN: (2015-12-11 )
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100...---....110.......120.......130...-....140...-.....-------150.......-----160.......170.......180.......190.......200..----.....210--........--220.....---.--.230...--..--...-240----.......250..----------....---------.260-----.--------......270.......280.......290-.......300..-----.....310-----...-----.....320.......330.......340......-.350.......360.......370.......380.......390.....-..400-..--..-----.....--410---.......420.......430----------------..----.....440---........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550......-.560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
F
H
V
E
G
L
I
A
I
I
V
F
Y
L
L
I
L
L
V
G
I
W
A
A
WRTKNSGS
A
E
E
RS
E
A
I
I
VGG
R
D
I
G
L
L
VG
G
F
T
M
T
A
T
W
VGGGYINGTA
E
A
V
Y
VPGYGLAWAQAPI
G
Y
S
L
S
L
I
L
G
G
L
F
FAKP---MRSKG
Y
V
T
ML
D
P
F
Q
Q
I
Y
G
KRMG
G
L
L
F
I
P
A
L
-
M
G
E
M
F
-
W
A
A
A
-
I
F
S
A
L-------G
A
T
I
S
V
I
I
DV-----
D
M
H
I
S
V
I
I
S
A
L
I
A
T
L
Y
T
L
V
G
G
L
Y
S
V
A
Y
T
D
V
V
Q
L
F
C
I
F
V
G
L
W
I
SVP----FALSHPA---VADI
G
F
T
A
--
V
H
A
KYQKP---W--LGT-V
D
S
--
S
E
--
V
Y
S
-
W
L
D
----
S
F
L
L
L
M
LGGI
P
W
----------
Q
A
Y
F
---------
Q
R
V
L
-----S--------SSS
A
T
Y
A
Q
V
L
S
F
L
A
A
F
G
C
L
V
M
A
I
P
A
I
L
I
G-AIGASTDWNQTA-----YGLPDPK------TTE-----EA
D
M
I
L
P
I
V
L
Q
Y
L
C
P
V
Y
I
S
F
F
G
L
G
A
V
S
A
A
V
M
SSA-
D
S
S
I
L
S
A
S
S
M
F
A
R
N
I
Y
Q
L
S
FRQNASDK
E
I
V
W
V
M
R
I
T
V
F
V
FGA
S
A
T
A
M
A
L
-
L
T
K
---
T
V
--
Y
G
-----
L
W
YLS--SD
L
---
V
Y
I
V
I
F
P
Q
L
L
C
V
L
FVKGTNT----------------
Y
G
----
A
V
A
G
Y
VS----
G
L
F
L
R
I
TGGE
P
Y
L
Y
L
Q
P
L
IFYPGYYPDDNGIYNQKFP
F
K
T
L
A
M
V
T
S
F
L
T
N
I
C
I
S
Y
L
A
K
Y
L
F
ESGTLPP
K
L
D
V
F
D
A
V
V
A
RHSEENMD
K
T
I
L
V
KNENIKLD
E
L
A
L
VKPRQ
S
M
T
L
SSTFT-NK
E
A
F
L
DVDSSPEGSGTEDNLQ
20
HHSearch
92.69
20%
-135
- C6 -
2XQ2
3
SGLT_VIBPH
A:
[9-504]
---
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
----------------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
--
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
-
N
L
T
S
-
V
L
Y
L
G
-------
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
----
M
A
V
S
F
I
G
G--
T
D
G
W
F
A
G
V
S
K
M
V
D
-
A
A
P
G
---
H
--
F
E
M
I
L
D
Q
SN
P
Q
YM
N
L
P
G
I
A
V
LIGG
L
W
V
A
N
L
Y
Y
W
G
F
N
----------
Q
Y
I
I
---------
Q
R
T
L
-----
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
-
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
G----
N
L
P
------
S
A
A
-----
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
-
M
L
G
GIG
Q
C
--
F
Q
-----
Y
I
Q
E
Y
--
T
G
L
---
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
----
S
I
P
F
A
L
F
L
-----
K
F
M
P
L
-
S
M
P
------------
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
-
I
G
T
I
L
L
I
S
Y
G
I
K
----------
30
Fugue
76.50
19%
-85
- C6 -
3DH4
1
?
A:
[52-518]
--------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
--
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
-
S
L
Y
I
F
V
N
L
T
S
-
V
L
Y
L
G
-------
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
------
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
----
M
A
V
S
F
I
G
GTD
G
W
F
A
G
V
S
K
--
M
V
D
A
A
P
G
H
---
F
--
E
M
I
-
L
D
Q
--
S
N
--
P
Q
Y
-
M
N
L
----
P
G
I
A
V
L
I
G
G
L
W
V
----------
A
N
L
Y
Y
WGFNQ
Y
I
I
Q
R
T
L
-----
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
-
I
A
A
Y
V
I
T
S
D
P
Q
L
-----
M
A
S
L
G
D
I
AATNLP
S
A
A
-----
N
A
D
K
A
Y
P
W
L
T
Q
F
L
-
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
-
M
L
G
---
G
I
--
G
Q
-----
A
F
Q
Y
I
--
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
----
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
------------------------
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
-----
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
--------------------------
31
Fugue
74.84
21%
-110
- C3 -
1O75
4
TA47_TREPA
A:
[7-414]
---------
E
T
S
Y
G
Y
A
T
L
S
Y
A
D
Y
W
A
G
E
L
--------
G
Q
S
R
D
V
L
L
A
D
L
D
A
G
M
F
--------------------
D
A
V
S
R
A
T
H
G
H
G
A
F
R
Q
Q
F
Q
Y
A
V
E
V
L
G
E
K
V
L
S
K
Q
E
---
T
E
D
S
R
-------------
G
R
K
K
W
E
Y
E
T
D
P
S
-
V
T
K
M
V
-
R
A
S
A
-
S
F
Q
D
L
-------
G
E
D
G
E
I
K
F
E
A
-----
V
E
G
A
V
A
L
A
D
R
--
A
S
S
F
M
V
D
S
E
E
Y
K
I
T
N
V
K
V
H
G
M
K
F
V
P
V
----
A
V
P
----
H
E
L
K
G
I
A
---
K
E
K
F
H
F
----------------------
V
E
D
--
S
R
--
V
T
E
-
N
T
N
----
G
L
---------------------------------
K
T
M
L
-----
T
--------
E
D
S
F
S
A
R
K
V
S
S
--------------------------------------
M
E
S
P
H
------
D
--------------
L
V
V
D
T
V
G
T
G
Y
H
S
R
F
G
S
D
A
E
A
S
V
M
L
K
R
A
-
D
G
S
E
L
S
H
R
E
F
I
D
Y
V
M
N
F
N
T
V
R
Y
D
Y
Y
G
D
D
A
S
Y
T
N
L
M
A
S
Y
G
------------
T
K
---
H
S
--
A
D
-----
S
W
W
K
T
--
G
R
V
---------
P
R
I
S
C
G
I
------
N
----------------
Y
G
-----------------
F
D
R
F
K
G
S
G
P
G
Y
Y
R
L
T
L
I
A
N
-
G
Y
---
R
D
V
V
A
D
V
R
F
L
P
K
-------
Y
E
G
N
I
D
I
G
L
K
G
K
V
L
T
I
G
G
A
D
A
E
T
L
--
M
D
A
A
V
D
V
F
A
D
---
G
Q
P
K
L
V
S
D
Q
A
V
S
L
G
---------
Q
N
V
L
S
A
D
F
T
P
G
T
E
Y
T
V
E
V
R
F
K
E
F
G
S
V
R
A
K
V
V
A
1
PsiBlast_PDB
74.84
23%
-130
- C6 -
2XQ2
3
SGLT_VIBPH
A:
[9-400]
------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
-------------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
--
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
--------
A
V
F
-
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
----
M
A
V
S
F
I
G
---
G
T
D
G
W
F
A
G
--
V
S
K
M
V
D
A
A
PGH
F
--
E
M
I
-
L
D
Q
--
S
N
--
P
Q
Y
-
M
N
L
----
P
G
I
A
V
L
I
G
G
L
-
W
V
A
N
L
Y
Y
WGFN
Q
Y
I
I
---------
Q
R
T
L
-----
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
-----
A
S
L
G
-----------
N
LPSAA
N
A
D
K
A
Y
P
W
L
T
Q
F
L
-
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
-
M
L
G
---
G
I
--
G
Q
-----
C
F
Q
Y
I
--
Q
E
Y
---
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
----------------
T
T
----
S
K
G
A
I
I
G
----
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
--------------------------
2
PsiBlast_PDB
68.90
26%
-82
- C6 -
3DH4
1
?
A:
[80-442]
---------------------------------------------------------------
G
S
G
Y
S
I
G
L
A
I
A
S
Y
------
E
W
M
S
A
-----
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
--------
A
V
F
-
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
----
M
A
V
S
F
I
G
---
G
T
D
G
W
F
A
G
--
V
S
K
M
V
D
A
A
PGH
F
--
E
M
I
-
L
D
Q
--
S
N
--
P
Q
Y
-
M
N
L
----
P
G
I
A
V
L
I
G
G
L
-
W
V
A
N
L
Y
Y
WGFN
Q
Y
I
I
---------
Q
R
T
L
-----
A
--------
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
-----
A
S
L
G
D
I
A
------
A
T
N
LPSAA
N
A
D
K
A
Y
P
W
L
T
Q
F
L
-
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
----
A
L
I
I
A
C
-
L
I
A
---
P
M
--
L
G
GIGQ
A
F
Q
Y
I
Q
E
Y
T
G
L
---
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-----------------------------------------------------------
22
HHSearch
57.89
11%
-123
- C6 -
2JLN
-
?
A:
[22-453]
-------------------------------------------
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
--
M
T
S
S
F
Q
V
W
Q
--
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
G
-
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
S
L
I
P
I
T
L
K
A
-
L
L
S
L
F
-
W
F
G
F
-
Q
T
W
L
G
-------
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
----
L
M
L
D
G
A
D
---
V
-
S
L
G
E
V
---
M
S
M
-
G
G
E
N
-----------
P
G
--
M
P
--
F
S
T
-
A
I
M
----
I
F
V
G
G
W
I
A
V
V
V
S
----------
I
H
D
I
---------
V
K
E
C
-----
K
VDPNAS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
-
A
A
S
M
V
L
V
-------------
G
----------
E
W
-----
N
P
V
I
A
I
T
E
V
V
G
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
V
F
T
----------
F
K
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
F
A
---
G
V
--
L
N
-----
T
F
L
N
L
--
L
A
S
---
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
R
IS
L
H
D
L
Y
RTKGIYTYW
R
G
VN
W
V
A
L
A
V
Y
A
V
----
A
L
A
V
S
F
L
T
-----
P
--------
D
-------------
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
------------------------------------------------------------
7
PsiBlast_PDB
49.02
24%
-133
- C7 -
3F2F
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
D
-
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
C
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.86
25%
-137
- C7 -
3FN8
1
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
D
-
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
-
E
I
Q
A
V
E
P
A
G
M
A
-----
V
S
L
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
C
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.28
24%
-136
- C7 -
3F2H
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
--
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
S
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.14
24%
-137
- C7 -
3F0P
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
D
-
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
C
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
48.03
24%
-132
- C7 -
3F0O
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
D
-
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
C
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.58
24%
-138
- C7 -
3F2G
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
----
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
S
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.56
24%
-143
- C7 -
1S6L
-
MERB_ECOLX
A:
[72-193]
----------------------------------------------------------------------------------------
I
G
Y
G
L
T
L
--------------
R
E
T
S
Y
V
F
E
I
D
D
-
R
R
L
Y
A
W
C
A
L
D
T
L
I
F
P
A
L
-
I
G
R
T
A
-
R
V
S
S
-
H
C
A
A
T
-------
G
A
P
V
S
L
T
V
S
P
-----
S
E
I
Q
A
V
E
P
A
G
M
A
V
S
L
------
V
L
P
Q
E
A
A
D
V
R
Q
S
F
C
C
H
V
H
F
F
A
S
V
P
T
A
E
D
W
A
S
K
H
Q
G
---
L
E
G
L
A
I
V
S
--
V
H
E
A
F
G
L
G
---
Q
--
E
F
N
-
R
H
L
--
L
Q
--
T
M
S
-
S
R
T
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
46.24
17%
-61
- C4 -
2E2E
2
NRFG_ECO57
A:
[2-177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
Q
A
--
V
R
A
E
Y
Q
R
Q
---
R
D
P
L
H
Q
-
F
A
E
--
A
Q
--
L
Q
A
-
L
Q
D
----
K
I
R
A
N
P
Q
N
S
E
Q
W
----------
A
L
L
G
---------
E
Y
Y
L
W
Q
ND
Y
S
--------
N
S
L
L
A
Y
R
Q
A
L
Q
L
R
G
E
N
A
E
L
Y
A
A
L
A
T
V
L
Y
Y
-
Q
A
S
Q
H
M
T
-
A
Q
T
R
-----
A
M
I
D
K
A
L
------
A
L
D
-----
S
N
E
I
T
A
L
M
L
L
A
S
D
A
F
M
Q
A
N
Y
A
Q
A
I
E
L
W
Q
K
V
M
D
L
N
-
S
P
R
I
--
N
R
T
Q
L
V
E
S
I
N
M
A
K
L
L
Q
R
R
S
D
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.78
25%
-128
- C5 -
1EVZ
1
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
17
PsiBlast_PDB
44.81
25%
-127
- C5 -
1N1E
1
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
12
PsiBlast_PDB
44.75
25%
-127
- C5 -
1EVY
-
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
15
PsiBlast_PDB
44.15
25%
-129
- C5 -
1M66
1
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
16
PsiBlast_PDB
44.01
25%
-135
- C5 -
1M67
1
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
18
PsiBlast_PDB
43.72
25%
-131
* C5 *
1N1G
1
GPDA_LEIME
A:
[9-107]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
---
K
C
R
E
V
C
-----
V
W
H
M
N
--
E
E
E
---
V
R
L
V
-
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
----------------
A
S
----
N
I
T
-
F
T
S
----
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
G
D
R
S
F
V
C
-
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G