@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO1C1_HUMAN: (2015-12-12 )
MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------.........10........20..----------------......30........40..------....----..50........60........70...-......80...----.....90........100--.......110.-..---....120.---.---.....130.......140....----------...150.......160.......170.......180.......--------------------190.......----200.......210....---------------------...220.......230-----.....-...240.......250.......260.....-..270--.........280.......290-----...-..-...-.300.......310----........320.......330......-------------------.340...-....350.......360.......370--..-.....380.-.---.....390.......400.......410..--.....420-----.........430.--......----440.......450.......460.......470---.........-480.......490....-----...500.......510.....--------..520.......530.......------540.......550.......--------560--.......570-.......580--........590.......600.......610.......620.......630.......640.......650.......660.......-------670.....----------------..680.......690.......700.......710-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------MDTSSKE
N
I
Q
L
F
C
KTSVQPVGRP----------------SFKTEYPSSEEKQP
C
C
G
E
L
K
------
V
F
L
C
----
A
L
S
F
V
Y
F
A
K
A
L
A
E
G
Y
L
K
S
T
I
T
Q
I
-
E
R
R
-FDI
P
S
S
L
V
G
VI----DGSFEIGN
L
L
V
I
T
F
V
S
Y
F
--
G
AKLHRPKIIG-AG---
C
V
I
M
G
V
G
T
---
L
---
L
I
A
M
P
Q
F
F
M
E
Q
Y
K
YERYSPSSN----------
S
T
L
S
I
S
P
CLLESSSQL
P
V
S
V
M
E
K
S
K
S
KISNECEVDTSS
S
M
W
I
Y
--------------------
V
F
L
G
N
L
L
R
GI----GETPIQP
L
G
I
A
Y
L
D
DFA---------------------SEDN
A
A
F
Y
I
G
C
V
Q
T
V
------
A
I
I
G
P
-
I
F
G
F
L
L
G
S
L
C
A
K
L
Y
V
D
I
G
F
V
N
L
D
H
I
T
ITPKD-P
Q
W
----
V
G
A
W
W
L
G
Y
L
I
A
G
I
I
S
L
L
A
A
V
-------
P
F
W
-YL-PKS-LPRSQSREDSNSS-----SEK
S
K
F
I
IDDHTDYQTPQGEN
A
K
I
M
E
M
-------------------
A
R
D
F
L
P
S
-
L
K
N
LFGN
P
V
Y
F
L
Y
L
CTS
T
V
Q
F
N
S
L
F
G
M--VT-Y
K
P
K
Y
I
E
Q
Q
-Y---GQSSSRA
N
F
V
I
G
L
INI
P
A
V
A
L
G
I
FSG
G
I
V
M
--
K
K
F
R
I
S
-------VCGA
A
K
L
Y
L
G
S
S
V
--
F
G
Y
L
L
F
----
L
S
L
F
ALGCENSDVA
G
L
T
V
S
YQGTKPV
S
Y
H
E
R
-----
A
L
F
S
DCNSR-CKCSETKWEPMCGEN
G
I
-----
T
Y
V
S
A
C
L
AGCQTSNRSG
K
N
I
I
--------
F
YN
C
T
C
V
G
I
A
ASKSGNSSG
I
V
G
------RCQKDNG
C
P
Q
M
F
L
Y
F
L
V
I
S
V
--------
I
T
S
--
Y
T
LSLGG
I
P
G
-
Y
I
L
L
L
R
C
I
K
---
P
Q
L
K
S
F
A
L
G
I
Y
T
L
A
I
R
V
L
AGIPA
P
V
Y
F
G
V
L
ID
T
S
C
L
K
W
G
F
K
RCGSRG
S
C
R
L
YD
S
N
V
F
R
H
I
Y
L
G
L
T
V
I
L
G
T
V
S
I
L
L
S
I
A
V
L
F
I
L
K
K
N
Y
V
-------
S
K
H
R
S
F
I
T
----------------
K
R
E
R
T
M
V
S
T
R
F
QKENYTTSDHLLQPNYWPGKETQL-------------------
17
Fugue
75.89
15%
-88
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------------------------------------------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
----------------
G
Y
D
T
A
V
I
S
G
--------------------------------
T
V
E
S
L
N
T
V
F
---
V
A
P
Q
-
N
L
S
-
E
S
A
A
N
S
L
L
G
F
C
----
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
--
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
I
S
G
---
V
---
G
S
A
W
P
E
L
G
F
T
S
I
--------------------
N
P
D
N
T
V
P
V
Y
L
A
G
Y
---------------------------
V
P
E
--------------------
F
V
I
Y
R
I
I
G
G
I
----
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
---------------------
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
------
I
I
F
G
Q
-
L
L
V
Y
C
V
N
Y
F
I
A
R
----------------
S
G
D
-
A
S
W
----
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
-------
L
F
L
-
M
L
-
L
Y
T
-
V
P
E
S
P
R
W
L
M
S
R
G
K
-----
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
-------------------
L
D
H
G
R
K
T
-
G
G
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
-
Y
Y
A
P
E
V
F
K
T
-
L
---
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
--
K
F
G
R
------------
K
P
L
Q
I
I
G
A
L
G
--
M
A
I
G
M
F
----
S
L
G
T
A
F
Y
---------------------------------------------------------------------------------------------------------------------------
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
--------
V
A
A
--
F
A
M
S
W
G
-
P
V
C
-
W
V
L
L
S
E
I
F
P
---
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
-----------------------
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
-------
T
K
G
K
T
L
E
E
----------------
L
E
A
L
-----------------------
W
E
-------------------------
19
Fugue
74.11
11%
-92
- C1 -
4B3F
-
SMBP2_HUMAN
X:
[1-646]
----------------------------------------------------------------------------------
S
A
A
V
E
S
F
V
T
K
Q
L
D
L
L
E
L
E
----------------
R
D
A
E
V
E
E
R
R
S
W
Q
E
N
I
S
L
K
E
L
------
Q
S
R
G
----
V
C
L
L
K
L
Q
V
S
S
Q
R
T
G
L
Y
G
R
L
L
V
T
F
-
E
P
------
R
R
Y
A
A
L
P
----
S
N
S
F
T
S
G
D
I
V
G
L
Y
D
A
A
N
E
--
G
S
Q
L
-----
A
T
-
G
I
---
L
T
R
V
T
Q
K
S
---
V
---
T
V
A
F
D
------------
S
L
D
R
E
----------
N
S
Y
R
L
L
K
L
A
N
D
V
T
Y
R
R
L
K
K
A
L
I
A
L
K
K
Y
H
S
G
P
-----
A
S
S
L
I
E
V
--------------------
L
F
G
R
S
A
P
S
P
A
----
S
E
I
H
P
L
T
F
F
N
T
C
L
D
--
T
---------------------
S
Q
K
E
A
V
L
F
A
L
S
Q
K
E
L
------
A
I
I
H
G
-
P
P
G
T
G
K
T
T
T
V
V
E
I
I
L
Q
A
V
K
Q
G
-
L
K
V
L
C
C
A
P
S
-
N
I
A
----
V
D
N
L
V
E
R
L
A
L
C
K
Q
R
I
L
R
L
G
H
-------
P
A
R
-
L
L
-
E
S
I
-
Q
Q
H
S
L
D
A
V
L
A
R
S
D
SAQIV
A
D
I
R
K
D
I
D
Q
V
F
V
K
N
K
K
K
S
N
F
R
N
E
I
K
L
L
-------------------
R
K
E
L
K
E
R
-
E
E
A
A
M
L
E
S
L
T
S
A
N
V
V
L
A
T
N
T
G
A
S
A
D
G
P
--
L
K
L
L
P
E
S
Y
F
D
V
V
-
V
---
I
D
E
C
A
Q
A
L
E
A
S
C
W
I
P
L
L
K
A
R
K
C
I
L
A
G
D
H
K
Q
--
L
P
P
T
T
V
-------
S
H
K
A
A
L
A
G
L
S
L
S
L
--
M
E
R
L
A
E
----
E
Y
G
A
R
V
------
V
R
T
L
T
V
Q
Y
R
M
H
Q
A
I
M
R
W
A
S
-----
D
T
M
Y
L
--------
G
Q
L
T
A
H
S
S
V
A
R
H
L
L
-----
R
D
----
L
P
G
V
A
A
T
E
E
T
G
V
P
L
L
--------
L
V
D
T
A
G
C
G
L
F
E
L
E
S
-----------------
K
G
N
P
G
E
V
R
L
V
S
L
H
I
Q
A
L
--------
V
D
A
GV
P
A
R
D
I
A
V
V
S
P
-
Y
N
L
Q
V
D
L
L
R
---
Q
S
L
V
H
R
H
P
E
L
E
I
K
S
V
D
G
F
Q
G
R
E
K
E
A
V
I
L
S
F
V
----------
R
S
N
R
K
G
E
V
G
F
L
A
E
--
D
R
R
I
N
V
A
V
T
R
A
R
R
H
V
A
V
I
C
D
S
R
T
V
N
--
N
H
A
F
L
-------
K
T
L
V
E
Y
F
T
----------------
Q
H
G
E
V
R
T
A
F
E
Y
L
D
D
I
V
P
-------------------------------------
24
HHSearch
59.85
17%
-89
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[31-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
----
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
--
M
K
K
L
S
Y
K
A
G
I
I
-
T
G
---
L
F
L
Y
A
L
G
A
---
A
---
L
F
W
P
A
A
E
I
M
---------------------------------
N
-----------------------------
Y
T
L
--------------------
F
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
---------------------
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
------
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
-
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
-------
L
I
M
-
L
T
--
K
F
-
P
A
L
Q
S
D
N
H
S
-
D
A
--------------------------------
K
-------------------
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
--
W
S
-
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
-
C
F
F
I
G
R
F
T
G
T
W
L
I
--
S
R
F
A
P
H
-------
K
V
L
A
A
Y
A
L
I
A
M
A
L
--
C
L
I
S
A
F
----
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
-----
L
G
Q
D
T
K
Y
G
S
-
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
-----
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
--------
A
V
I
F
I
F
A
R
F
R
S
Q
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
59.10
17%
-67
- C1 -
2GFP
-
EMRD_ECOLI
A:
[21-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
----
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
--
S
D
R
V
G
R
R
P
V
I
L
-
V
G
---
M
S
I
F
M
L
A
T
---
L
---
V
A
V
T
T
S
------------------------------------
S
-----------------------------
L
T
V
--------------------
L
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
---------------------
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
------
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
---------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
-------
S
M
A
-
R
W
M
P
E
T
-
R
P
V
D
A
---
P
-
R
------------------------------------------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
--
E
A
-
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
-
A
A
F
F
G
A
W
F
A
G
R
P
N
--
K
R
F
S
T
L
-------
M
W
Q
S
V
I
C
C
L
L
A
G
L
--
L
M
W
I
P
D
----
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
-----
A
M
E
P
F
P
F
L
A
-
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
-----
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
--------
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
58.42
12%
-94
- C1 -
3F2B
3
?
A:
[7-1030]
VRRLETIVEEER
R
V
V
V
Q
G
Y
V
F
D
A
E
V
S
E
L
KSG
R
T
L
L
T
M
K
I
T
DYT
N
S
I
L
V
K
M
F
S
RD
K
E
D
A
E
L
M
S
G
VKKG
M
W
V
K
V
R
G
S
V
Q
N
D
T
F
V
R
D
L
V
I
I
A
N
D
L
N
E
I
A
A
N
E
R
QDTAPEGE
K
R
V
E
L
H
L
H
T
P
M
S
Q
M
D
A
V
T
S
V
T
K
L
I
E
Q
A
K
K
W
GHP
A
I
A
V
T
D
H
AV
V
Q
S
F
P
E
A
Y
S
A
A
K
K
H
G
M
K
-
V
I
Y
G
L
-
E
A
N
-
I
V
D
D
P
F
H
V
T
L
L
A
QN
E
T
G
L
K
N
L
F
K
L
V
S
L
S
H
I
Q
Y
F
HR
V
P
R
I
P
R
S
V
L
V
K
H
R
D
---
G
L
L
V
G
S
G
C
---
D
KGE
L
F
D
N
V
E
D
I
A
R
F
Y
D
F
L
E
V
H
P
P
D
V
YKPLYVKD
E
E
M
I
K
N
I
I
R
S
I
V
A
L
G
E
K
L
D
I
P
V
V
A
T
G
N
V
H
Y
L
N
P
E
D
K
I
Y
R
K
I
L
I
H
S
Q
GGANPLNR
H
E
L
P
DVYFRT
T
N
E
M
L
D
C
F
S
F
L
----
G
P
E
K
A
K
E
I
V
V
D
N
T
Q
K
I
A
S
L
IGDVKPIKD
E
L
Y
T
P
R
I
E
G
A
D
E
E
I
R
E
M
S
Y
R
R
A
K
E
I
YGDPLP
K
L
V
E
E
-
R
L
E
K
E
L
K
S
I
I
G
H
G
F
A
V
I
Y
L
I
S
H
K
L
V
K
K
S
L
D
D
-
G
Y
L
----
V
G
S
R
--
G
S
V
G
S
S
F
V
A
T
M
T
E
I
TEVNPL
P
P
H
Y
-
V
C
-
P
N
C
K
H
S
E
F
F
N
D
G
S
V
G
S
G
-----
F
D
L
P
D
K
N
C
P
R
C
G
T
K
Y
K
K
D
G
H
D
I
P
F
E
T
F
LGFKGD
K
V
P
D
I
D
L
N
F
SGEY
Q
P
R
A
H
N
Y
-
T
K
V
L
F
G
E
D
N
V
Y
R
A
G
T
I
G
T
V
A
D
K
T
A
Y
G
F
--
V
----
K
A
Y
A
S
D
H
N
L
---
E
L
R
G
A
E
I
D
R
L
A
A
G
C
T
G
V
K
R
T
T
G
Q
H
P
G
G
I
I
V
V
P
D
Y
M
E
I
Y
D
F
T
P
I
Q
Y
P
A
D
D
T
S
S
E
W
R
T
T
H
--
F
D
F
H
S
I
HDN
L
L
K
L
D
I
L
G
H
D
D
P
T
V
I
R
M
L
Q
D
L
S
G
I
D
P
K
T
I
P
T
D
D
P
D
V
M
G
I
F
S
S
-
T
E
P
-
L
G
V
T
P
E
Q
I
M
C
N
V
G
T
I
G
I
PEFGT
R
F
V
R
Q
M
L
E
E
T
R
P
K
T
F
S
E
L
V
Q
I
S
G
L
S
H
GTD
V
W
L
G
N
A
Q
E
L
I
Q
N
G
T
C
T
L
S
E
V
I
G
C
R
D
D
I
M
V
Y
L
I
Y
R
G
L
E
P
S
L
A
F
K
I
M
E
S
V
R
K
GKGLT
P
E
F
E
--
A
E
M
R
K
H
D
V
P
E
W
Y
I
D
S
C
K
K
I
K
Y
M
F
P
K
A
H
A
A
A
Y
V
L
M
A
V
R
I
A
Y
F
K
V
H
H
P
L
L
Y
Y
A
S
Y
F
T
V
R
A
E
D
F
D
L
D
A
M
I
K
G
S
A
A
I
R
K
R
I
E
E
I
N
A
K
G
I
Q
A
T
A
K
E
K
S
L
L
T
V
L
E
V
A
L
E
M
C
E
R
G
F
S
F
K
N
IDLYR
S
Q
A
T
E
F
V
I
DGN
S
L
I
P
P
FNAIPGLG
T
N
V
A
Q
A
I
V
R
A
R
E
E
G
E
F
L
S
K
E
D
L
Q
Q
R
G
K
L
S
K
T
L
L
E
Y
L
E
S
R
GCLDSLPDHNQLSLF
23
HHSearch
48.06
12%
-91
- C1 -
1PW4
-
GLPT_ECOLI
A:
[34-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
----
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
--
S
D
R
S
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
A
V
M
---
L
---
F
M
G
F
V
P
W
A
T
S
--------------------------------
S
-----------------------------
I
A
V
--------------------
M
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
---------------------
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
------
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
--------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
-------
F
A
F
A
M
M
-
R
D
T
-
P
Q
S
C
G
L
P
P
I
E
E
Y
K
-----
N
D
----------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
--
L
D
-
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
-
A
G
I
P
G
T
L
L
C
G
W
M
S
--
D
K
V
F
R
G
-------
N
R
G
A
T
G
V
F
F
M
T
L
V
--
T
I
A
T
I
V
----
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
-----
L
H
A
L
E
L
A
P
K
-
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
-----
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
--------
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
------
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
45.05
9%
-48
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------------------------------------------------------------------------------------------
F
K
P
----------------
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
------
W
Q
I
F
----
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
-
L
V
E
-
Q
G
F
S
R
G
D
L
G
F
A
----
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
--
S
D
R
S
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
A
V
M
---
L
---
F
M
G
F
V
P
W
A
T
----------
S
S
I
----------
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
--------------------
A
H
N
V
G
G
G
-----------
I
P
P
L
L
F
L
L
G
M
A
W
F
---------------------
N
D
W
H
A
A
L
-----
Y
M
P
------
A
F
C
A
I
-
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
-
Q
I
F
----
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
-------
Y
L
L
-
R
Y
-
G
I
L
-
D
W
S
P
T
Y
L
K
E
V
K
H
F
-----
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
-------------------
D
K
V
F
R
G
N
-
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
--
T
V
-
D
M
I
C
M
I
V
I
G
-
F
---
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
--
L
F
G
Y
L
G
-------
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
----
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
-----
E
L
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
44.78
16%
-109
- C1 -
3WDO
-
?
A:
[24-180]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
----
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
--
S
D
R
I
G
R
K
P
L
I
V
-
G
G
---
L
A
V
F
A
A
G
S
---
V
---
I
A
A
L
S
D
------------------------------------
S
-----------------------------
I
W
G
--------------------
I
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
---------------------
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
------
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
---------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
-------
L
T
I
-
W
V
-
V
P
N
-
S
S
T
H
V
L
N
R
E
S
G
M
V
-----
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
-------------------
M
S
T
F
V
A
L
-
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
--
S
V
-
V
P
F
I
I
Y
A
E
V
-
K
---
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
--
L
V
V
G
V
Q
-------
L
F
F
V
A
F
N
L
M
E
A
L
L
--
P
S
L
I
S
K
----
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
-----
I
D
G
M
F
D
G
Q
G
-
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
-----
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
--------
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
------
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
--------
A
I
R
--
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
42.30
13%
-57
- C1 -
2CFQ
-
LACY_ECOLI
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
-
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
----
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
--
S
D
K
L
G
L
R
K
Y
L
L
-
W
I
I
T
G
M
L
V
M
F
A
P
F
---
F
---
I
F
I
F
G
P
L
-----------------------------------
L
-----------------------------
Q
Y
N
--------------------
I
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
---------------------
R
--
R
S
N
F
E
F
G
R
A
R
M
F
------
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
I
----------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
-------
L
L
F
-
F
A
-
K
T
D
-
A
P
S
S
A
T
V
A
N
-
A
V
G
------
A
-----------------------
N
H
-------------------
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
--
D
Q
-
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
-
L
N
A
S
I
M
F
F
A
P
L
I
I
--
N
R
I
G
G
K
-------
N
A
L
L
L
A
G
T
I
M
S
V
R
--
I
I
G
S
S
F
----
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
-----
Q
F
E
V
R
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
-----
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
--------
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
------
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
39.28
16%
-104
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[36-178]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
--
D
I
-
L
L
P
Q
F
Q
Q
A
--
F
---
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
-
G
Y
F
I
I
P
I
P
A
G
I
L
M
--
K
K
L
S
Y
K
---------
A
G
I
I
T
G
L
F
L
Y
A
--
L
G
A
A
L
F
----
W
P
A
A
E
-------------------------------------------------------------------------------------------------------------------------------
I
-
M
N
Y
T
L
F
L
V
G
L
F
--------
I
I
A
--
A
G
L
G
C
L
E
T
A
A
-
N
P
F
V
T
V
L
G
P
---
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
-------
Q
S
D
N
H
S
D
A
----------------
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
-------------------
30
HHSearch
37.45
11%
-110
- C1 -
3WDO
-
?
A:
[12-159]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
--
L
P
-
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
-
T
Q
A
V
F
Q
I
P
F
G
L
L
S
--
D
R
I
G
R
K
---------
P
L
I
V
G
G
L
A
V
F
A
--
A
G
S
V
I
A
----
A
---
L
S
--------------------------------------------------------------------------------------------------------------------------------
D
S
I
W
G
I
I
L
G
R
A
--------
L
Q
G
--
S
G
--
A
I
A
A
A
V
-
M
A
L
L
S
D
L
T
R
---
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
-
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
-------
L
N
F
G
I
M
C
L
----------------
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
-------------------
6
PsiBlast_PDB
35.44
40%
193
- C2 -
1AN1
-
LDTI_HIRME
I:
[4-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
K
I
-
L
K
P
V
C
G
S
D
G
R
-----
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
--------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
34.95
12%
-103
* C1 *
1PW4
-
GLPT_ECOLI
A:
[280-431]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
----
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
--
S
D
K
V
F
R
G
N
R
G
A
-
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
---
V
Y
W
M
N
P
A
---
G
-------------------------------
N
-----------------------------
P
T
V
--------------------
D
M
I
C
M
I
V
I
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
---------------------
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
------
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
---------------------------
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
-------
L
L
I
-
V
V
-
M
I
G
-
E
K
R
R
H
E
Q
L
L
Q
E
L
V
-----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
34.88
38%
190
- C2 -
1LDT
-
LDTI_HIRME
L:
[3-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
C
A
C
P
K
-
I
L
K
P
V
C
G
S
D
G
R
-----
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
--------
P
T
G
I
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
34.51
30%
160
* C2 *
2F3C
-
?
I:
[5-34]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
C
A
C
P
R
-
V
L
H
R
V
C
G
S
D
G
N
-----
T
Y
S
N
P
C
T
L
D
C
A
K
H
E
G
K
P
D
L
V
Q
--------
V
H
E
G
P
C
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
34.30
22%
50
- C2 -
2ERW
-
?
A:
[4-50]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
-
C
A
C
F
R
-
N
Y
V
P
V
C
G
S
D
G
K
-----
T
Y
G
N
P
C
M
L
N
C
A
A
Q
T
K
V
P
G
L
K
L
--------
V
H
E
G
R
C
Q
R
S
N
V
E
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
33.66
26%
156
- C2 -
1CGJ
-
ISK1_HUMAN
I:
[7-41]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
Y
N
E
L
N
G
C
T
L
-
E
Y
R
P
V
C
G
T
D
G
D
-----
T
Y
P
N
E
C
V
L
C
F
E
N
R
K
R
Q
T
S
I
L
I
--------
Q
K
S
G
P
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
33.61
40%
222
- C2 -
2KMR
-
LDTI_HIRME
A:
[4-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
K
I
-
L
K
P
V
C
G
S
D
G
R
-----
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
--------
P
T
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
33.35
10%
-96
- C1 -
2GFP
-
EMRD_ECOLI
A:
[21-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
A
Q
T
I
Y
--
I
P
-
A
I
A
D
M
A
R
D
--
L
---
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
-
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
--
D
R
V
G
R
R
---------
P
V
I
L
V
G
M
S
I
F
M
--
L
A
T
L
V
A
----
V
---
T
T
--------------------------------------------------------------------------------------------------------------------------------
S
S
L
T
V
L
I
A
A
S
A
--------
M
Q
G
--
M
G
T
G
V
G
G
V
M
A
-
R
T
L
P
R
D
L
Y
E
---
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
-
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
-------
L
M
L
I
G
G
L
A
----------------
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
-------------------
9
PsiBlast_PDB
31.98
40%
207
- C2 -
2KMQ
-
LDTI_HIRME
A:
[4-29]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
C
P
K
I
-
L
K
P
V
C
G
S
D
G
R
-----
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
--------
P
T
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------