@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SO2A1_HUMAN: (2015-12-12 )
MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
Atome Classification :
(20 SA)
------------.........10........20........30........40........50........-60-.-.......70........80........90........100.....---..110...-...-----.120.......130....----...140..-.....150.......160...-...-.170.......180---.----.......190.......200.......210........-220------.......230.......240.-......250..----......260.......270.......280.......290.......300.......310......-.320.......330.......340.......350....-.---..360---.......370.......380.......390.......400.......410.......420.......430.......440-----.....-..450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610-......--------..620.......630.......640.--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MGLLPKLGASQGSDTS
T
S
R
A
G
R
C
A
R
S
V
FGNI
K
V
F
V
L
C
Q
G
L
L
Q
L
C
Q
L
L
Y
S
A
Y
F
K
S
S
L
T
T
I
-
E
K
-
R
-FGLSSSSS
G
L
I
S
S
L
N
E
IS
N
A
I
L
I
I
F
V
S
Y
F
GSRVHR
P
R
L
I
GI
G
G
L
F
---
L
AA
G
A
F
I
L
-
T
L
P
-----
H
F
LSEP
Y
Q
Y
T
L
ASTGNN
S
----
R
L
Q
A
E
L
C
Q
-
K
H
W
QDL
P
P
S
KCHSTTQN
P
Q
K
E
-
T
S
S
-
M
W
G
L
M
V
V
A
Q
L
L
AG----I----GTVPIQPFGI
S
Y
V
DDFSEPSNS
P
L
Y
I
S
I
-
L
F
A
I
S
V
F
G
P
-
A
F
G
------
Y
L
L
G
S
V
M
L
Q
I
F
V
DYGRV
N
T
A
A
-
V
NLVPGD-PR
W
----
I
G
A
W
W
L
G
L
L
I
S
S
A
L
L
V
L
TS
F
P
F
F
FFPRAMPIGAKRAPA
T
A
D
E
A
R
K
L
E
E
A
KSR
G
S
L
V
D
F
I
K
R
F
P
C
I
-
F
L
R
L
L
M
N
S
L
F
V
L
V
V
L
A
Q
C
T
F
S
S
V
I
A
G
L
S
T
F
L
N
K
F
L
E
K
Q-Y---GT
S
A
A
---
Y
A
N
F
L
I
GAVN
L
P
A
A
A
L
G
M
L
F
G
G
I
L
M
K
R
F
V
F
S
L
Q
A
I
P
R
I
A
T
T
I
I
T
I
S
M
I
L
C
V
P
L
F
F
MGCSTP
T
V
A
E
V
YPPSTSSSIHPQSP-----ACRRD-CSC
P
D
S
I
FHPVCGDNG
I
E
Y
L
S
P
C
HAGCSNINMSSATS
K
Q
L
I
Y
L
N
C
S
CVTGGSASAKTGSCPV
P
C
A
H
F
L
L
P
A
I
F
L
I
S
F
V
S
L
I
A
C
ISHN
P
L
Y
M
M
V
L
R
V
VNQEE
K
S
F
A
I
G
V
Q
F
L
L
M
R
L
L
A
WLPSP
A
L
Y
G
L
TIDHSCI
R
W
N
S
LCLGRRG
A
C
A
YYD
N
D
A
L
R
D
R
Y
L
G
L
Q
M
--
G
Y
K
A
L
G
--------
M
L
L
L
C
F
I
S
W
RVKKNKEY
N
V
Q
K
AAGLI--
19
Fugue
82.93
13%
-116
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
------
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
---
A
A
A
V
M
L
F
M
-
G
F
V
-----
P
W
A
T
S
S
I
----------------------------------------------------
A
V
M
F
V
L
L
F
L
C
G
----
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
------
P
L
L
F
L
L
G
M
A
W
F
---------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
----------------
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
---
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
-----------------
Y
W
M
N
P
A
G
N
------------------------------------------------------------------------------------
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
---------------------
G
W
D
G
G
F
M
V
M
I
G
--
G
S
I
L
A
V
--------
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----
23
Fugue
74.80
13%
-89
- C1 -
3V9J
2
AL4A1_MOUSE
A:
[20-563]
HM
L
R
W
K
H
T
S
S
L
K
V
A
N
E
P
I
L
A
F
S
Q
G
S
P
E
R
D
A
L
Q
K
A
L
K
D
L
K
G
Q
T
E
A
I
P
C
V
V
G
D
-------------
E
E
V
W
T
S
D
-
I
Q
-
Y
-
Q
L
S
P
F
N
H
A
H
K
V
A
K
F
C
Y
A
D
K
A
L
L
N
R
A
I
D
A
A
L
A
A
R
K
E
W
D
L
K
P
----
M
---
A
D
R
A
Q
V
F
L
-
K
A
A
-----
D
M
L
S
G
P
R
R
A
E
V
L
A
K
T
M
V
G
QGKT
V
I
Q
A
E
I
D
A
A
A
E
L
I
D
F
F
R
F
N
A
K
F
A
V
E
L
E
G
E
Q
-
P
I
S
-
V
P
P
S
T
N
H
T
V
Y
R
G
L
----
E
----
G
F
V
----
A
A
I
S
P
F
N
F
T
A
I
G
G
N
L
A
G
A
P
A
L
-
M
G
N
V
V
L
W
K
P
-
S
D
T
------
A
M
L
A
S
Y
A
V
Y
R
I
L
R
E
A
G
L
P
P
N
I
-
I
Q
F
V
P
A
D
--------------
G
P
T
F
G
D
T
V
T
S
S
E
H
L
C
G
I
N
F
T
G
-----------
S
V
P
T
F
K
H
L
W
R
Q
V
A
Q
N
--
L
D
R
F
R
T
F
P
R
L
-
A
G
E
C
G
G
K
N
F
H
F
V
H
-------------------------------
S
S
A
D
---
V
D
S
V
V
S
G
T
L
R
S
A
F
E
Y
G
G
Q
K
C
S
A
--
C
S
R
L
Y
V
P
K
S
L
W
P
Q
I
K
G
R
L
L
E
E
H
S
R
I
---------------
K
V
G
D
P
A
E
D
F
G
T
F
F
S
A
V
-----
I
D
A
K
A
-
F
A
R
I
K
K
W
L
E
H
A
R
S
S
P
S
L
S
I
L
A
----------------------------
G
G
Q
C
N
E
S
V
G
-------
Y
Y
V
E
P
C
I
I
E
S
K
D
P
Q
E
P
I
M
--
K
E
E
I
F
G
P
V
L
T
V
Y
V
Y
P
D
D
K
Y
R
E
T
L
K
L
V
D
S
-
T
T
S
Y
G
L
T
G
A
V
F
A
Q
D
K
A
I
V
Q
E
A
T
R
M
L
---
R
N
A
A
G
N
F
Y
I
N
D
K
S
T
G
S
V
V
G
Q
Q
P
F
G
G
A
R
A
S
G
TNDKPGGP
H
Y
I
L
R
W
T
S
P
Q
V
I
K
E
T
H
K
P
L
G
D
W
R
Y
S
Y
MQ
30
HHSearch
65.97
15%
-110
* C3 *
3O7Q
1
FUCP_ECOLI
A:
[34-326]
----------------------------------------------------
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
-
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
---
Y
A
L
G
A
A
L
F
-
W
P
A
-----
A
E
---------------------------------------------------
I
M
N
-
Y
T
-
L
F
L
V
G
L
F
I
I
A
----
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
------
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
-
V
L
-
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
-
K
F
P
A
L
-
Q
S
D
N
H
-
S
D
A
----------------
K
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
---
F
A
A
N
Y
L
T
-
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
-----
N
L
G
Q
D
-
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
62.01
15%
-95
- C3 -
1PW4
-
GLPT_ECOLI
A:
[37-320]
----------------------------------------------------
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
--
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
---
A
A
A
V
M
L
F
M
-
G
F
V
-----
P
W
-------------------------------------------------
A
-
T
S
S
-
I
A
-
V
M
F
V
L
L
F
L
C
G
----
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
------
P
L
L
F
L
L
G
M
A
W
F
---------------------------
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
---
K
S
S
W
A
Y
F
-
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
-----
G
L
H
A
L
-
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
57.73
17%
-90
- C3 -
2GFP
-
EMRD_ECOLI
A:
[19-271]
-------------------------------------------------------
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
-
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
I
---
F
M
L
A
T
L
V
A
-
V
T
T
-----------------------------------------------------------
S
S
-
L
T
-
V
L
I
A
A
S
A
M
Q
G
----
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
------
P
L
I
G
G
L
L
D
T
M
W
----------------------------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
-
R
----------------------
T
R
L
L
T
S
-
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
---
T
V
S
I
L
F
I
-
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
-----
G
A
M
E
P
-
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
55.77
10%
-98
- C1 -
4KS9
-
?
A:
[2-417]
---------------------
T
R
A
T
K
R
Q
R
D
Q
L
R
Q
C
F
D
A
R
L
T
D
V
A
A
N
A
A
A
Q
A
W
Q
D
E
Y
E
A
A
V
E
P
L
R
Q
A
M
L
G
V
L
-
A
E
-
V
-
A
A
V
R
D
A
T
A
S
G
L
S
Q
A
L
S
N
A
R
I
R
F
F
K
R
F
A
A
L
H
G
N
S
A
C
----
G
L
H
F
L
I
---
Q
L
R
A
D
M
L
R
-
W
H
K
RIPGL
R
E
L
D
E
D
L
E
A
L
F
S
N
W
F
D
V
G
----
L
L
E
L
Q
P
I
T
-
W
D
S
P
A
S
L
L
E
K
L
I
R
Y
W
T
D
L
R
N
R
L
D
S
D
-
R
R
C
Y
A
F
F
H
P
R
I
P
R
EPL
I
F
----
V
E
V
A
F
V
P
E
M
A
A
N
V
Q
A
L
L
D
L
R
R
V
K
--
W
A
I
-
F
Y
S
I
S
N
T
Q
A
-
G
L
R
GVSFGN
F
L
L
K
R
V
I
E
E
L
Q
R
E
H
P
K
L
K
Q
F
A
T
L
S
P
I
P
G
F
-
A
D
W
----
L
R
K
-------
R
D
G
E
S
I
D
R
V
L
G
V
K
R
L
A
R
W
R
E
Q
H
G
E
V
P
A
D
G
A
A
W
F
S
A
L
S
A
D
T
E
D
T
V
I
R
D
T
A
M
T
L
A
A
H
-
Y
L
V
R
E
G
G
K
G
V
P
A
D
P
V
A
R
F
H
L
G
N
G
-
A
C
V
E
R
V
N
W
G
A
D
M
S
R
-
K
---
G
R
A
Q
S
CG
M
M
V
N
Y
L
Y
V
P
D
A
L
D
D
N
L
A
R
L
G
D
G
N
P
R
I
S
R
A
V
A
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
52.97
19%
-111
- C3 -
3WDO
-
?
A:
[20-182]
------------------------------------------------------
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
-
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
---
F
A
A
G
S
V
I
A
-
A
L
S
-----------------------------------------------------------
D
S
-
I
W
-
G
I
I
L
G
R
A
L
Q
G
----
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
------
M
V
L
G
P
I
I
T
H
K
L
----------------------------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
-
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
-
V
---
V
P
F
I
I
---
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
-----
G
V
A
I
G
-
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------------------------------------------------------------------------------------------
33
HHSearch
48.81
13%
-87
- C3 -
2CFQ
-
LACY_ECOLI
A:
[17-290]
------------------------------------------------------
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
-
L
H
-
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
-
I
F
G
-----------------------------------------------------------
P
L
L
Q
Y
-
N
I
L
V
G
S
I
V
G
G
----
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
------
A
S
I
V
G
I
M
F
T
I
-----------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
G
--------------
A
N
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
---
V
F
G
Y
V
T
T
-
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
-----
S
Q
F
E
V
-
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
42.82
8%
-53
- C3 -
1PW4
-
GLPT_ECOLI
A:
[274-410]
-----------------------------------------------------------------
D
W
S
P
T
Y
-
L
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
---
M
T
L
V
T
I
A
T
I
V
Y
W
-------
M
N
P
------------------------------------------------
A
G
N
-
P
T
-
V
D
M
I
C
M
I
V
I
G
----
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
------
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
-
G
G
S
I
L
A
V
-
I
L
L
----
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
42.73
30%
54
- C2 -
2ARP
2
FST_RAT
F:
[71-130]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
K
C
K
K
T
C
R
D
V
F
C
P
G
S
S
T
C
V
V
D
Q
T
N
NAYCV
T
C
N
R
I
-
C
P
E
P
S
S
S
E
Q
S
L
C
G
N
D
G
V
T
Y
S
S
A
C
H
L
R
K
A
T
C
L
L
G
R
S
I
G
L
A
Y
E
G
K
C
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.67
44%
114
- C2 -
2F3C
-
?
I:
[5-32]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
C
A
C
P
-
R
V
L
H
R
V
C
G
S
D
G
N
T
Y
S
N
P
C
T
L
D
C
A
K
H
E
G
K
P
D
L
V
Q
V
H
E
G
P
C
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
41.59
48%
128
- C2 -
2F3C
-
?
I:
[5-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
C
A
C
P
R
-
V
L
H
R
V
C
G
S
D
G
N
T
Y
S
N
P
C
T
L
D
C
A
K
H
E
G
K
P
D
L
V
Q
V
H
E
G
P
C
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
40.76
29%
134
- C2 -
1CGJ
-
ISK1_HUMAN
I:
[6-37]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
-----
K
C
Y
N
E
L
N
G
C
T
L
-
E
Y
R
P
V
C
G
T
D
G
D
T
Y
P
N
E
C
V
L
C
F
E
N
R
K
R
Q
T
S
I
L
I
Q
K
S
G
P
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
40.50
30%
14
- C2 -
2B0U
-
FST_HUMAN
C:
[131-190]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
R
C
K
K
T
C
R
D
V
F
C
P
G
S
S
T
C
V
V
D
Q
T
N
N
A
Y
C
V
T
C
N
R
I
-
C
P
E
P
A
S
S
E
Q
Y
L
C
G
N
D
G
V
T
Y
S
S
A
C
H
L
R
K
A
T
C
L
L
G
R
S
I
G
L
A
Y
E
G
K
C
I
K
A
K
S
C
E
D
I
Q
C
T
G
G
K
K
C
L
W
D
F
K
V
G
R
G
R
C
S
L
C
D
E
L
C
P
D
S
K
S
D
E
P
V
C
A
S
D
N
A
T
Y
A
S
E
C
A
M
K
E
A
A
C
S
S
G
V
L
L
E
V
K
H
S
G
S
C
N
--------------------------------------------------------------------------------------
34
HHSearch
39.54
13%
-66
- C3 -
2CFQ
-
LACY_ECOLI
A:
[257-376]
--------------------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
---
M
S
V
R
I
I
G
S
-
S
F
A
-----------------------------------------------------------
T
S
-
A
L
-
E
V
V
I
L
K
T
L
H
M
----
F
----
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
------
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
-
L
V
A
L
G
F
T
-
L
I
S
----
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
39.49
37%
71
- C2 -
1AN1
-
LDTI_HIRME
I:
[2-39]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-
C
A
C
P
-
K
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.42
37%
67
- C2 -
1LDT
-
LDTI_HIRME
L:
[1-39]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
-
C
A
C
P
-
K
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.23
30%
53
- C2 -
3HH2
-
FST_HUMAN
C:
[131-190]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
R
C
K
K
T
C
R
D
V
F
C
P
G
S
S
T
C
V
V
D
Q
T
N
N
A
Y
C
V
T
C
N
R
I
-
C
P
E
-----
Q
Y
L
C
G
N
D
G
V
T
Y
S
S
A
C
H
L
R
K
A
T
C
L
L
G
R
S
I
G
L
A
Y
E
G
K
C
I
K
A
K
S
C
E
D
I
Q
C
T
G
G
K
K
C
L
W
D
F
K
V
G
R
G
R
C
S
L
C
D
E
L
C
P
E
P
V
C
A
S
D
N
A
T
Y
A
S
E
C
A
M
K
E
A
A
C
S
S
G
V
L
L
E
V
K
H
S
G
S
C
N
-------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.08
37%
88
- C2 -
2KMQ
-
LDTI_HIRME
A:
[1-39]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
-
C
A
C
P
-
K
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
39.04
48%
174
- C2 -
1LDT
-
LDTI_HIRME
L:
[3-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
C
A
C
P
K
-
I
L
K
P
V
C
G
S
D
G
R
T
Y
A
N
S
C
I
A
R
C
N
G
V
S
I
K
S
E
G
S
C
P
T
G
I
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------