@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAA1_HUMAN: (2015-12-07 )
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20....---....30........40.---.......50-...--......60---.-........70.--..---.....80--------........-90.....----------------------...100.......110-----------.....-.--..---.120-.---........130-----.----......----.140.---......150.--......160.......170...----...-.180..---.....----190.......200.......----210..-.-.-----...--------.220--.......-------.---------230-...--.-..-.240.......250...-------....-----260.......270..----.....280..---.---------..---..290..---------------.-----..--.----.-300......----.310----..-.----------------..--------------------...------.320..--.....330...-------..--..340.---......350.......360--.......370.------.....----------------------.380-------.--------......-----.390......-.400--.........410........420----.......430......--------------------------------.440.......450......---.460....-----...-.--470.......480.......490..----.....-500.......510.......520.-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGHTQQPSGRGNPRPAPSPSPVPG---TVPGA
S
E
R
V
A
L
K
K
E
I
G
L
---
L
S
A
C
T
I
I
I
--
G
N
I
--IGS
G
I
F
I----S-
P
K
G
V
LEHSGS
V
--
G
L
---
A
L
F
V
W
V
L--------GG
G
V
T
A
L
G
-
S
L
C
Y
A
E
L----------------------GVAIPKSGG
D
Y
A
Y
V
-------------
T
E
I
F
G
-
G
--
L
A
---
G
F
---
L
---
L
L
W
S
A
V
L
I
MY------P----T
S
L
A
V
I
----
S
M
TFS---NYVLQPVFPN--CIPP
T
T
A
S
R
V
L
S
M
A
C
L
M
L
L
T
WV----NSS-SV
R
W
A
T
---
R
I
Q
D
M
----FTG
G
K
L
L
A
L
S
L
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I
G
V
G
L
L
Q
I
----
F
Q
-
G
H
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-----ELR--------PSN---
A
F
A
F
W
MT-------P---------S
V
G
-
H
L
A
--
L
-
A
F
-
L
QGSFAFSG
W
N
F
L
N
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V
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-------
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-----
D
A
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KNLP
R
A
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---
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---
F
TAM
S
P
Q
---------------
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-----
L
L--S----S-N
A
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----
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TFGGI
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H
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A
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CG------
A
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M
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D
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-----
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----
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L
L
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P
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----
N
L
L
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A
Y
L
V
F
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--------------------------------
V
F
S
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ISEPMVCG
V
G
V
I
I
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LT---G
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P
-
I
F
F
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-----
G
V
F
-W--RSK
P
K
C
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H
R
L
T
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M
T
H
W
G
Q
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L
C
F
V
V
----YPQDA-PEEEENGPCPPSLLPATDKPSKPQ-----------------------------------------
21
Fugue
77.78
20%
-130
- C5 -
3GIA
7
Y609_METJA
A:
[3-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
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---
W
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---------------
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--------------------
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A
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---
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--
T
--
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Y
I
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A
------
L
G
V
L
F
----------------------
A
L
L
--------
F
--------
N
M
E
G
V
A
-----
S
I
T
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A
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F
M
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-
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----
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H
Y
I
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-
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G
G
R
K
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----
S
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V
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G
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F
L
L
L
L
Y
Y
Q
--------------------------------
W
I
T
N
R
F
V
F
Y
G
----
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I
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---
G
V
L
-
I
F
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I
-----
I
Y
R
-
K
--
V
T
K
---------------------------------------------
R
T
F
S
N
N
M
Y
V
K
S
-----------------------------------------
26
Fugue
76.23
21%
-116
* C3 *
4UIR
2
OLHYD_ELIME
A:
[2-646]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPITSKF
D
K
V
L
N
A
S
S
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Y
G
H
V
N
H
E
P
D
S
S
K
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Q
R
N
---
T
-
P
Q
K
S
M
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F
S
-------------------------
D
Q
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G
N
Y
Q
----
R
-
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G
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------
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----------------------
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-------------
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---
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---------------
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------
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---
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----
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DDLT
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-----
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F
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--------
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---
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---------
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-----
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----
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---
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----
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------
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----------------
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NNKTAPIIGIDNSTSGQSA
G
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------
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K
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L
A
A
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-------
N
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V
T
G
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------
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S
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N
RQPHFPEQPDD
V
L
V
--------
L
--------
W
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MDKEG
N
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K
T
M
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-
T
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----
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A
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-
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L
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----
N
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A
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T
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M
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MPRAKGD
R
P
R
VVPEGCKN
L
G
L
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N
D
V
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L
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RG---------------------------------------
13
HHSearch
72.03
21%
-119
- C5 -
3GIA
6
Y609_METJA
A:
[3-371]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
---
W
E
A
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M
A
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--
G
V
M
--
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G
A
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----
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-
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---
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--------
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----------------------
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A
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-------------
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G
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L
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M
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A
-----
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-----
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F
S
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------
23
Fugue
69.79
15%
-105
* C5 *
4DJK
-
GADC_ECOLI
A:
[12-501]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
L
L
G
---
F
F
A
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M
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A
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-------------
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---
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----
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H
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-----------------
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V
--
V
--
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
-------
N
E
M
S
-----
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
----
A
A
I
C
L
S
S
V
G
G
---
L
---------
S
I
---
A
M
V
I
P
G
N
---------------
E
-----
I
N
--
L
----
S
-
A
G
V
M
Q
T
F
T
V
----
L
M
SHVAPE
I
E
-
W
----------------
T
V
--------------------
R
V
I
------
S
A
L
L
L
L
--
G
V
L
A
E
I
A
S
W
I
V
-------
G
P
--
S
R
G
M
Y
V
---
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
--
P
V
T
L
V
I
S
Q
L
V
I
------
T
S
I
A
L
----------------------
I
I
L
T
N
TGGG
N
N
M
--------
S
F
L
I
A
L
-----
A
L
T
V
V
I
Y
L
C
A
-
Y
F
----
M
L
F
I
G
Y
I
V
L
V
L
-
K
H
P
D
L
K
R
T
F
N
I
P
GGK
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
--------------------------------
A
F
I
V
S
F
L
P
-------------------------------------------------
P
D
N
I
Q
G
D
S
T
D
M
----
Y
V
E
L
L
-
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
ARSP-------------------------------------
14
HHSearch
69.51
19%
-118
- C5 -
3L1L
2
ADIC_ECO57
A:
[7-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
---
I
P
V
T
L
M
V
S
--
G
A
I
--
M
G
S
G
V
F
L
----
L
-
P
A
N
L
A
S
T
-
G
G
----
I
---
A
I
Y
G
W
L
V
--------
T
I
I
G
A
L
G
L
-
S
M
V
Y
A
K
M
----------------------
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
-------------
R
R
C
F
G
-
P
--
F
L
---
G
Y
---
Q
---
T
N
V
L
Y
W
L
-
A
C
------
W
----
I
G
N
I
A
M
----
V
V
I
G
V
---
G
Y
L
S
Y
F
-
F
P
I
--
L
K
D
-
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
----
N
I
V
-
G
P
K
M
I
T
---
R
V
Q
A
V
----
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
----
R
G
-
E
------------
T
--------
Y
M
A
-------------------------------
A
I
Q
--
S
-
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
-------
G
V
V
K
-----
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
----
I
A
A
V
C
Y
V
L
S
T
---
T
---------
A
I
---
M
G
M
I
P
N
A
---------------
A
-----
L
R
--
V
----
S
-
A
S
P
F
G
D
A
A
R
----
M
A
------
L
G
-
D
T---------------
A
G
--------------------
A
I
V
------
S
F
C
A
A
A
--
G
C
L
G
S
L
G
G
W
T
L
-------
L
A
--
G
Q
T
A
K
A
---
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
--
T
P
V
A
G
L
I
I
V
G
I
------
L
M
T
I
F
----------------------
Q
L
S
--------
S
ISPNATK-
E
F
G
L
V
S
-----
S
V
S
V
I
F
T
L
V
P
-
Y
L
----
Y
T
C
A
A
L
L
L
L
G
H
-
G
H
F
G
K
A
R
P
A
Y
L
----
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
--------------------------------
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
---
A
L
N
-
Y
N
R
L
-----
H
K
N
-
P
--
Y
P
L
D
A
-----------------------------------------------------------------------------------------------
24
Fugue
67.37
13%
-116
- C3 -
3S28
3
SUSY1_ARATH
A:
[27-807]
N
E
V
L
A
L
L
S
R
V
E
A
K
G
K
G
I
L
Q
Q
N
Q
I
I
A
E
F
EALPEQTRKKLEGGP
F
F
D
L
L
K
S
TQ
E
A
I
V
L
P
P
W
V
A
L
A
V
R
PRPG
V
W
E
Y
L
R
V
N
LHAL
V
V
E
E
L
Q
P
A
E
F
L
H
F
K
E
E
L
V
DGVKNGNF
T
L
E
L
D
FEPFNAS
I
P
R
P
TLHKYIGN
G
V
D
F
L
N
R
H
L
S
A
K
L
FHDKESL
L
P
L
L
K
F
L
R
L
HSHQGKNLMLSEKIQN
L
N
T
L
Q
H
T
L
R
K
A
E
E
Y
L
A
E
L
K
S
E
T
L
Y
E
E
F
E
A
K
F
E
E
I
G
L
E
R
G
WGD
N
A
E
R
V
L
D
M
I
R
L
L
L
D
L
L
E
APD
P
C
T
L
E
T
F
L
--
G
R
V
PM
V
F
N
V
V
I
L
----
S
-
P
H
G
Y
F
A
Q
D
N
V
L
--
G
Y
PDT
G
G
Q
V
V
Y
I
--------
L
D
Q
V
R
A
L
E
-
I
E
M
L
Q
R
I
----------------------
K
Q
Q
G
L
N
I
K
P
R
I
L
I
L
-------------
T
R
L
L
P
-
D
--
A
V
---
G
T
---
T
---
C
G
E
R
L
E
R
V
Y
D
------
S
----
E
Y
C
D
I
L
----
R
V
P
F
R
T
EK
G
I
V
R
K
W
I
S
R
F
--
E
V
W
P
Y
L
E
T
Y
T
E
D
A
A
V
E
L
S
K
E
L
N
----
G
K
P
-
D
L
I
I
G
N
------------
Y
S
D
G
N
L
V
A
S
L
L
A
H
K
L
G
V
T
Q
C
----
T
I
-
A
H
A
L
-
E
-----
K
T
K
--------
Y
P
D
---
S
D
I
Y
W
K
K
-------
L
---------
D
D
K
Y
H
F
S
--
C
-
Q
F
-
T
A
D
I
F
A
M
N
H
T
D
F
I
I
T
S
T
-------
F
Q
E
I
-----
A
G
S
K
E
-------
T
V
G
----
Q
Y
E
S
H
T
A
F
T
L
---
P
---------
G
L
---
Y
R
V
V
H
G
I
---------------
D
-----
V
F
--
D
----
P
-
K
F
N
I
V
S
P
G
A
----
D
M
------
S
I
-
Y
----------------
F
P
--------------------
Y
T
E
------
E
K
R
R
L
T
--
K
F
H
S
E
I
E
E
L
L
Y
-------
S
D
VE
N
K
E
H
L
C
---
V
L
K
D
K
K
K
P
I
L
F
T
M
A
R
L
D
R
V
--
K
N
L
S
G
L
V
E
W
Y
G
K
N
T
R
L
R
E
L
A
N
L
----------------------
V
V
V
--------
G
G
DRRKESK
D
N
E
E
K
A
-----
E
M
K
K
M
Y
D
L
I
E
E
Y
K
LNGQ
F
R
W
I
S
S
Q
M
D
R
V
-
R
N
G
E
L
Y
R
Y
I
C
D
----
T
K
G
A
F
V
Q
P
A
L
Y
E
A
F
G
L
--------------------------------
T
---
V
V
E
A
M
T
C
G
L
P
T
F
A
T
C
K
---
G
G
P
-
A
E
I
I
VHGKS
G
F
H
-
I
D
P
Y
H
G
D
Q
A
A
D
T
L
A
D
F
F
T
K
C
K
E
D
P
--
S
H
----
W
D
E
I
S
-
K
G
G
L
Q
R
I
E
E
K
Y
T
W
Q
I
Y
S
Q
R
L
L
T
L
T
G
V
Y
G
F
W
K
H
V
S
NLDR
L
E
A
R
R
Y
L
E
M
F
Y
A
L
K
Y
R
P
L
A
Q
A
V
P
L
A
Q
D
7
PsiBlast_PDB
65.76
24%
-113
- C5 -
3L1L
2
ADIC_ECO57
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
---
I
P
V
T
L
M
V
S
--
G
A
I
--
M
G
S
G
V
F
L
----
L
-
P
A
N
-
L
A
S
T
G
----
G
I
---
A
I
Y
G
W
L
V
--------
T
I
-
I
G
A
L
G
L
S
M
V
Y
A
K
M
----------------------
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
-------------
R
R
C
F
G
-
P
--
F
L
---
G
Y
Q
T
N
V
---
L
Y
W
L
A
C
W
I
G
-------
N
----
I
A
M
V
V
I
----
G
V
G
Y
L
---
S
Y
----
F
F
P
I
--
L
K
D
P
----
W
V
L
T
I
T
C
V
V
V
L
-
W
I
F
V
L
L
N
I
V
-
G
P
K
M
I
T
---
R
V
Q
A
V
----
A
T
---
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
-------------
F
R
--------
G
E
T
---
Y
M
A
------------------------------
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
-------
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
----
I
A
A
V
C
Y
V
L
S
T
---
T
---------
A
----
I
M
G
M
I
P
N
---------------
A
-----
A
L
--
R
----
V
-
S
--
A
S
P
F
G
D
A
A
R
M
A
L
------
G
D
-
T
----------------
A
G
--------------------
A
I
V
------
S
F
C
A
A
A
--
G
C
L
G
S
L
G
G
W
T
L
-------
L
A
--
G
Q
T
A
K
A
---
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
--
T
P
V
A
G
L
I
I
V
G
I
------
L
M
T
I
F
----------------------
Q
L
S
--------
S
--------
I
S
P
N
A
T
-----
K
E
F
G
L
V
S
S
V
S
-
V
I
----
F
T
L
V
P
Y
L
Y
T
C
A
-
A
L
L
L
L
G
H
G
H
F
G
----
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
--------------------------------
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
---
M
V
I
-
T
A
M
Y
-----
A
L
N
-
Y
--
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.35
24%
-113
- C5 -
3OB6
1
ADIC_ECOLI
A:
[5-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
A
H
K
V
G
L
---
I
P
V
T
L
M
V
S
--
G
N
I
--
M
G
S
G
V
F
L
----
L
-
P
A
N
-
L
A
S
T
G
----
G
I
---
A
I
Y
G
W
L
V
---------
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
----------------------
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
-------------
R
R
C
F
G
-
P
--
F
L
---
G
Y
Q
T
N
V
---
L
Y
W
L
A
C
W
I
G
-------
A
----
I
A
M
V
V
I
----
G
V
G
Y
L
---
S
Y
----
F
F
P
I
--
L
K
D
P
L
----
V
L
T
I
T
C
V
V
V
L
-
W
I
F
V
L
L
N
I
V
-
G
P
K
M
I
T
---
R
V
Q
A
V
----
A
T
---
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
-------------
F
R
--------
G
E
T
---
Y
M
A
A
W
N
V
-------
S
---------
G
L
G
-
T
F
G
--
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
-------
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
----
I
A
A
V
C
Y
V
L
S
T
---
T
---------
A
----
I
M
G
M
I
P
N
---------------
A
-----
A
L
--
R
----
V
-
S
--
A
S
P
F
G
D
A
A
R
M
A
L
------
G
D
-
T
----------------
A
G
--------------------
A
I
V
------
S
F
C
A
A
A
--
G
C
L
G
S
L
G
G
W
T
L
-------
L
A
--
G
Q
T
A
K
A
---
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
--
T
P
V
A
G
L
I
I
V
G
I
------
L
M
T
I
F
----------------------
Q
L
S
--------
S
--------
I
S
P
G
L
V
-----
S
S
V
S
V
I
F
T
L
V
-
P
Y
----
L
Y
T
C
A
A
L
L
L
L
G
-
H
G
H
F
G
K
A
R
P
A
Y
----
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
--------------------------------
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
---
Y
A
L
-
N
Y
N
R
-----
L
H
K
-
N
--
P
Y
P
L
D
A
----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.26
25%
-105
- C5 -
3GIA
5
Y609_METJA
A:
[5-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
K
L
S
L
---
W
E
A
V
S
M
A
V
--
G
V
M
--
I
G
A
S
I
F
-----
S
-
I
F
G
V
G
A
K
I
A
G
R
--
N
L
---
P
E
-
T
F
I
L
--------
S
G
I
Y
A
L
L
V
-
A
Y
S
Y
T
K
L
----------------------
G
A
K
I
V
S
N
A
G
P
I
A
F
I
-------------
H
K
A
I
G
-
D
N
I
I
T
---
G
A
---
L
S
I
-
L
L
W
M
S
----
Y
------
V
----
I
S
I
A
L
F
----
A
K
G
F
A
---
G
Y
F
L
P
L
I
--
N
--
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
----
N
F
F
-
G
S
K
A
V
G
---
R
A
E
F
F
----
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
----
H
P
-
S
Y
V
I
-
P
-----
D
L
A
--------
P
S
A
---
V
S
G
M
I
F
A
-------
S
---------
A
I
F
-
F
L
S
-------------
Y
M
G
F
G
V
I
T
N
A
S
-------
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
----
I
V
M
F
V
Y
V
G
V
A
---
I
---------
S
A
---
I
G
N
L
P
I
D
---------------
E
-----
L
I
K
A
S
----
E
-
N
A
L
A
V
A
-
A
K
----
P
F
------
L
G
-
N
----------------
L
G
--------------------
F
L
L
I
-----
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
-------
G
G
--
A
N
V
A
Y
S
---
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
--
T
E
G
L
Y
I
T
S
A
L
G
------
V
L
F
A
L
----------------------
L
F
N
--------
M
--------
E
G
V
A
S
I
-----
T
S
A
V
F
M
V
I
Y
L
-
F
V
----
I
L
S
H
Y
I
L
I
D
E
V
-
G
G
R
K
E
I
V
I
F
S
F
----
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
--------------------------------
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
---
I
I
Y
-
R
K
V
T
-----
K
R
T
-
F
--
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.70
25%
-103
- C5 -
3GI9
-
Y609_METJA
C:
[5-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
K
L
S
L
---
W
E
A
V
S
M
A
V
--
G
V
M
--
I
G
A
S
I
F
-----
S
-
I
F
G
V
G
A
K
I
A
G
R
--
N
L
---
P
E
-
T
F
I
L
--------
S
G
I
Y
A
L
L
V
-
A
Y
S
Y
T
K
L
----------------------
G
A
K
I
V
S
N
A
G
P
I
A
F
I
-------------
H
K
A
I
G
-
D
N
I
I
T
---
G
A
---
L
S
I
-
L
L
W
M
S
----
Y
------
V
----
I
S
I
A
L
F
----
A
K
G
F
A
---
G
Y
F
L
P
L
I
-----
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
----
N
F
F
-
G
S
K
A
V
G
---
R
A
E
F
F
----
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
----
H
P
-
S
Y
V
I
-
P
-----
D
L
A
--------
P
S
A
---
V
S
G
M
I
F
A
-------
S
---------
A
I
F
-
F
L
S
-------------
Y
M
G
F
G
V
I
T
N
A
S
-------
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
----
I
V
M
F
V
Y
V
G
V
A
---
I
---------
S
A
---
I
G
N
L
P
I
D
---------------
E
-----
L
I
K
A
S
----
E
-
N
A
L
A
V
A
-
A
K
----
P
F
------
L
G
-
N
----------------
L
G
--------------------
F
L
L
I
-----
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
-------
G
G
--
A
N
V
A
Y
S
---
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
--
T
E
G
L
Y
I
T
S
A
L
G
------
V
L
F
A
L
----------------------
L
F
N
--------
M
--------
E
G
V
A
S
I
-----
T
S
A
V
F
M
V
I
Y
L
-
F
V
----
I
L
S
H
Y
I
L
I
D
E
V
-
G
G
R
K
E
I
V
I
F
S
F
----
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
--------------------------------
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
---
I
I
Y
-
R
K
V
T
-----
K
R
T
-
F
--
S
N
N
M
Y
V
K
S
L
E
S
-----------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.26
24%
-124
- C5 -
3LRC
-
ADIC_ECO57
A:
[6-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
H
K
V
G
L
---
I
P
V
T
L
M
V
S
--
G
N
I
--
M
G
S
G
V
F
L
----
L
-
P
A
N
-
L
A
S
T
G
----
G
I
---
A
I
Y
G
W
L
V
---------
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
----------------------
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
-------------
R
R
C
F
G
-
P
--
F
L
---
G
Y
Q
T
N
V
---
L
Y
W
L
A
C
W
I
G
-------
N
----
I
A
M
V
V
I
----
G
V
G
Y
L
---
S
Y
----
F
F
P
I
--
L
K
D
P
L
----
V
L
T
I
T
C
V
V
V
L
-
W
I
F
V
L
L
N
I
V
-
G
P
K
M
I
T
---
R
V
Q
A
V
----
A
T
---
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
-------------
F
R
--------
G
E
T
---
Y
M
A
A
W
N
V
-------
S
---------
G
L
G
-
T
F
G
--
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
-------
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
----
I
A
A
V
C
Y
V
L
S
T
---
T
---------
A
----
I
M
G
M
I
P
N
--------------------------------------------------------
T
----------------
A
G
--------------------
A
I
V
------
S
F
C
A
A
A
--
G
C
L
G
S
L
G
G
W
T
L
-------
L
A
--
G
Q
T
A
K
A
---
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
--
T
P
V
A
G
L
I
I
V
G
I
------
L
M
T
I
F
----------------------
Q
L
S
--------
S
--------
I
S
P
N
A
T
-----
K
E
F
G
L
V
S
S
V
S
-
V
I
----
F
T
L
V
P
Y
L
Y
T
C
A
-
A
L
L
L
L
G
H
G
H
F
G
----
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
--------------------------------
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
---
M
V
I
-
T
A
M
Y
-----
A
L
N
-
Y
--
N
R
L
H
K
N
P
---------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.00
25%
-104
- C5 -
3GI8
-
Y609_METJA
C:
[5-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
K
L
S
L
---
W
E
A
V
S
M
A
V
--
G
V
M
--
I
G
A
S
I
F
-----
S
-
I
F
G
V
G
A
K
I
A
G
R
--
N
L
---
P
E
-
T
F
I
L
--------
S
G
I
Y
A
L
L
V
-
A
Y
S
Y
T
K
L
----------------------
G
A
K
I
V
S
N
A
G
P
I
A
F
I
-------------
H
K
A
I
G
-
D
NI
I
T
---
G
A
---
L
SI-
L
L
W
M
S
----
Y
------
V
----
I
S
I
A
L
F
----
A
K
G
F
A
---
G
Y
F
L
P
L
I
--
N
--
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
----
N
F
F
-
G
S
K
A
V
G
---
R
A
E
F
F
----
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
----
H
P
-
S
Y
V
I
-
P
-----
D
L
A
--------
P
S
A
---
V
S
G
M
I
F
A
-------
S
---------
A
I
F
-
F
L
S
-------------
Y
M
G
F
G
V
I
T
N
A
S
-------
E
H
I
E
-----
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
----
I
V
M
F
V
Y
V
G
V
A
---
I
---------
S
A
---
I
G
N
L
P
I
D
---------------
E
-----
L
I
KA
S
----
E
-
N
A
L
A
V
A
-
A
K
----
P
F
------
L
G
-
N
----------------
L
G
--------------------
F
L
L
I-----
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
-------
G
G
--
A
N
V
A
Y
S
---
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
--
T
E
G
L
Y
I
T
S
A
L
G
------
V
L
F
A
L
----------------------
L
F
N
--------
M
--------
E
G
V
A
S
I
-----
T
S
A
V
F
M
V
I
Y
L
-
F
V
----
I
L
S
H
Y
I
L
I
D
E
V
-
G
G
R
K
E
I
V
I
F
S
F
----
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
--------------------------------
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
---
I
I
Y
-
R
K
V
T
-----
K
R
T
-
F
--
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.90
24%
-122
- C5 -
3LRB
-
ADIC_ECO57
A:
[6-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
H
K
V
G
L
---
I
P
V
T
L
M
V
S
--
G
N
I
--
M
G
S
G
V
F
L
----
L
-
P
A
N
-
L
A
S
T
G
----
G
I
---
A
I
Y
G
W
L
V
---------
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
----------------------
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
-------------
R
R
C
F
G
-
P
--
F
L
---
G
Y
Q
T
N
V
---
L
Y
W
L
A
C
W
I
G
-------
N
----
I
A
M
V
V
I
----
G
V
G
Y
L
---
S
Y
----
F
F
P
I
--
L
K
D
P
L
----
V
L
T
I
T
C
V
V
V
L
-
W
I
F
V
L
L
N
I
V
-
G
P
K
M
I
T
---
R
V
Q
A
V
----
A
T
---
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
-------------
F
R
--------
G
E
T
---
Y
M
A
A
W
N
V
-------
S
---------
G
L
G
-
T
F
G
--
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
-------
A
S
V
A
AGVVK
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
----
I
A
A
V
C
Y
V
L
S
T
---
T
---------
A
----
I
M
G
M
I
P
N
--------------------------------------------------------
T
----------------
A
G
--------------------
A
I
V
------
S
F
C
A
A
A
--
G
C
L
G
S
L
G
G
W
T
L
-------
L
A
--
G
Q
T
A
K
A
---
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
--
T
P
V
A
G
L
I
I
V
G
I
------
L
M
T
I
F
----------------------
Q
L
S
--------
S
--------
I
S
P
N
A
T
-----
K
E
F
G
L
V
S
S
V
S
-
V
I
----
F
T
L
V
P
Y
L
Y
T
C
A
-
A
L
L
L
L
G
H
G
H
F
G
----
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
--------------------------------
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
---
M
V
I
-
T
A
M
Y
-----
A
L
N
-
Y
--
N
R
L
H
K
N
P
---------------------------------------------------------------------------------------------
25
Fugue
47.73
13%
-132
- C3 -
4IA6
12
?
A:
[1-591]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
D
K
K
S
A
---
Y
I
I
G
S
G
--------
L
A
G
---
L
S
T
A
V
F
L
V
R
D
A
Q
M
--
K
G
E
N
I
H
I
L
E
EL
P
-
V
A
G
F
V
V
R
G
G
R
E
M
E
N
H
---
F
E
C
L
W
D
M
Y
R
S
IPSLE
V
P
G
A
S
Y
L
D
-
E
Y
Y
W
L
D
K
E
D
P
N
S
S
NCRLIYNRGDRLPSDG
Q
Y
G
L
G
K
C
A
N
E
I
V
K
L
I
M
TPEKEIEGQTI
E
E
F
F
S
-
D
--
E
F
F
K
T
N
F
---
W
---
T
Y
W
S
T
M
F
A
F
E
------
K
WHS
L
A
E
M
R
R
Y
----
A
M
R
F
I
---
H
H
I
D
G
L
P
D
F
T
--
A
L
K
F
N
K
Y
N
Q
Y
E
S
M
V
K
P
L
L
A
Y
L
K
----
D
H
G
V
Q
F
E
Y
D
C
---
H
V
K
N
V
E
V
D
-
H
E
G
D
S
K
I
A
K
K
I
V
M
T
Q
N
-----------
G
K
-
D
-
K
-----
E
I
D
--------
L
T
H
---
N
D
I
V
F
V
T
NGSITES
S
---------
T
Y
G
-
D
Q
N
--
T
-
P
A
-
P
I
T
N
A
K
G
D
S
W
K
L
W
E
N
L
A
-------
K
Q
-------
D
P
A
F
G
H
P
D
V
F
C
E
N
L
P
ERSW
F
V
S
A
T
A
T
L
E
N
KKL
A
---------
P
Y
---
F
E
R
L
T
K
R
---------------
S
LYDGK
V
N
--
T
----
G
-
G
I
I
T
I
V
D
S
N
----
W
E
------
L
S
-
F
T
I
H
RQPHFKSQNPD
Q
I
V
V
--------------------
W
I
Y
A
LYSDT
E
G
N
Y
I
K
--
K
R
I
V
D
C
T
G
K
E
I
-------
A
E
--
E
L
L
Y
H
L
---
G
V
P
E
S
Q
I
S
E
L
A
S
E
---
E
N
M
--
N
T
V
P
V
Y
M
P
Y
I
T
------
S
Y
F
M
P
----------------------
R
R
D
--------
G
--------
D
R
P
D
V
V
-----
P
E
G
S
-
I
N
L
A
F
-
I
G
-------------------
N
F
A
E
S
P
T
R
----
D
T
V
F
T
T
E
Y
S
V
R
T
A
M
E
A
--------------------------------
V
Y
T
L
L
N
-----------
V
D
R
---
G
V
P
-
E
V
F
D
-----
S
I
Y
D
I
--
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
L
A
D
Q
D
M
---
P
----
L
P
E
K
L
-
A
V
K
T
G
M
R
K
I
K
K
T
W
V
E
E
L
L
K
E
A
N
L
V
-----------------------------------------
29
Fugue
46.83
17%
-153
- C2 -
4RKS
2
MV3K_THEAC
A:
[21-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
R
S
I
G
-
S
T
A
Y
P
T
I
----------------------
G
V
V
L
L
--
G
G
I
A
N
P
V
-------------
T
R
-----------------
T
---
P
L
H
T
S
A
G
I
A
Y
S
D
SCGS
I
----
R
S
E
T
R
I
----
Y
A
D
E
A
---
T
H
I
Y
F
N
G
T
E
S
--
T
D
D
N
R
S
V
R
R
V
L
D
R
Y
S
S
V
F
E
E
A
F
----
G
T
K
-
T
V
S
Y
S
S
---
Q
N
F
G
I
----
L
S
G
S
S
-
D
A
G
A
A
S
I
G
A
A
I
L
G
L
----
K
P
------------
D
L
D
--------
P
H
D
---
V
E
N
D
L
---------
R
---------
A
V
S
-
E
S
A
--
G
-
R
S
-
L
F
G
G
L
T
I
T
W
S
D
G
F
H
A
Y
T
-------
E
K
I
L
-----
D
------
P
E
A
F
S
G
Y
S
----
I
V
A
F
A
F
D
Y
Q
R
----------------------
N
P
S
---------------
D
-----
V
I
--
H
----
Q
-
N
I
V
R
S
D
L
Y
P
----
A
R
------
K
K
-
H
----------------
A
D
--------------------
E
H
A
------
H
M
I
K
E
Y
--
A
K
T
N
D
I
K
G
I
F
D
L
A
Q
E
D
T
E
E
Y
--
H
S
I
L
R
G
V
GV
N
V
I
R
E
N
M
Q
K
L
I
S
Y
L
K
L
I
R
K
--
D
Y
W
N
A
Y
I
V
T
G
G
------
S
N
V
Y
V
----------------------
A
V
E
--------
S
--------
E
N
A
D
R
L
-----
F
S
I
E
--
N
T
F
G
-
S
K
----
K
K
M
L
R
I
V
G
G
A
W
H
R
R
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
40.33
41%
84
- C7 -
3GD9
-
?
A:
[48-77]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
G
N
P
P
T
P
A
P
D
A
S
-
I
P
G
---
P
A
P
G
R
S
T
T
I
Q
I
P
K
F
S
G
R
---
I
Y
F
S
Y
G
R
K
--
M
E
F
--
R
L
T
T
G
G
L
----
V
-
Q
P
A
V
Q
N
P
T
D
P
N
--
R
D
---
I
L
F
N
W
S
E
--------
Y
T
L
N
D
S
G
L
-
W
I
N
S
T
Q
V
----------------------
D
M
F
S
A
P
Y
T
V
G
V
R
R
G
-------------
D
G
T
T
L
-
S
--
T
G
---
K
L
---
R
---
P
G
G
Y
N
G
V
F
N
A
------
L
----
R
G
Q
S
G
G
----
W
A
N
L
I
---
Q
T
R
S
D
G
T
V
L
R
--
A
L
S
P
L
Y
G
V
E
T
G
A
L
P
A
S
V
M
D
D
Y
I
----
N
R
V
-
W
N
K
Y
T
G
---
T
D
L
I
V
----
T
P
F
A
D
R
P
D
V
R
Y
T
G
R
V
S
G
G
V
L
----
R
F
-
T
D
-
G
-
S
-----
G
A
V
--------
V
T
T
---
F
Q
K
P
D
A
S
-------
S
---------
V
F
G
-
C
H
R
--
L
-
L
D
-
A
P
V
R
G
P
I
S
R
T
L
C
A
G
F
N
R
-------
T
T
L
L
-----
A
N
P
H
Q
P
D
R
S
A
A
G
F
Y
Q
----
E
P
V
T
N
H
Y
A
R
I
---
I
---------
H
A
---
H
M
A
D
G
K
A
---------------
Y
-----
G
F
--
A
----
F
-
D
D
V
G
H
H
E
S
L
----
V
H
------
D
G
-
D
----------------
P
R
--------------------
G
A
S
------
L
T
L
D
P
F
--
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
37.13
41%
352
* C7 *
3GD0
-
?
A:
[82-111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
G
N
P
P
T
P
A
P
D
A
S
-
I
P
G
---
P
A
P
G
R
S
T
T
I
Q
I
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
34.12
8%
-99
- C5 -
3DH4
1
?
A:
[52-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
S
L
P
W
---
W
A
V
G
A
S
L
I
--
A
A
N
--
I
S
A
E
Q
F
I
----
G
M
S
G
S
G
Y
S
-
I
G
L
A
-------
I
A
S
Y
E
W
M
--------
S
A
I
T
L
I
I
V
-
G
K
Y
F
L
P
I
----------------------
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
-------------
E
K
R
F
N
-
K
--
K
L
---
K
T
---
I
---
L
A
V
F
W
I
S
L
Y
I
------
F
----
V
N
L
T
S
V
----
L
Y
L
G
G
---
L
A
L
-
E
T
I
L
G
I
---
P
L
--
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
----
I
-------
V
V
---
W
T
D
V
I
----
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
----
G
G
T
D
G
-
W
F
A
G
V
S
K
M
V
D
A
--------
A
P
G
HFE
M
I
L
D
Q
S
N
-------
P
QYM------
N
L
P
-
G
I
A
VL
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
-------
L
A
A
K
-----
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
----
L
K
L
I
V
P
F
L
V
V
---
L
---------
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLP
S
-----
A
A
--
N
----
A
-
D
K
A
Y
P
W
L
T
-----
Q
F
------
L
P
-
V
G---------------
V
K
--------------------
G
V
V
------
F
A
A
L
A
A
--
A
I
V
S
S
L
A
S
M
L
N
-------
S
T
--
A
T
I
F
T
------
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
--
V
N
V
G
R
T
A
A
V
V
A
------
L
I
I
A
C
----------------------
L
I
A
--------
P
--------
M
L
G
G
I
G
-----
Q
A
F
Q
Y
I
Q
E
Y
T
-
G
L
----
V
S
P
G
I
L
A
V
F
L
L
-
G
L
F
W
K
K
T
T
S
K
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
--------------------------------
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
---
V
V
I
-
A
F
T
S
-----
L
S
T
-
S
--
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
----
A
Y
G
I
M
-
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
--------------------------------------------------
28
Fugue
31.94
15%
333
- C3 -
2JPW
-
TNNI3_MOUSE
A:
[1-32]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
E
S
S
D
A
A
G
E
P
Q
P
A
P
A
P
V
---
R
R
R
S
S
A
N
Y
R
A
Y
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
29.12
34%
30
* C4 *
3J7Y
-
RM16_HUMAN
N:
[68-138]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
S
-
D
I
R
G
P
S
---
T
E
A
T
E
----
F
T
E
G
N
F
A
I
L
A
L
--
G
G
G
Y
L
H
------
W
-
G
H
-
F
-
E
-----
M
M
R
LTINRSMD
P
K
N
---
M
F
A
I
W
R
V
-------
P
APFKPITRK
S
V
G
-
H
R
M
--
G
-
G
G
-
K
G
A
I
D
H
Y
V
T
P
V
K
A
G
R
L
V
-------
V
E
M
G
-----
G
R
C
E
F
E
E
V
Q
G
F
L
D
Q
V
----
A
H
K
L
P
F
A
A
K
A
---
V
---------
S
R
---
G
T
L
E
K
M
R
---------------
K
-----
D
Q
--
E
----
E
-
R
E
R
N
N
Q
N
P
W
----
T
F
------
E
R
-
I
----------------
A
T
--------------------
A
N
M
------
L
G
I
R
K
V
--
L
S
P
Y
D
L
T
H
K
G
K
-------
Y
W
--
G
K
F
Y
M
P
---
K
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------