@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACATN_HUMAN: (2015-12-07 )
MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN
Atome Classification :
(20 SA)
-.........10....-------....20........30........40........50........60........70........80.....----------...90.-.......100.-....---...110........120.......--.130------...--.....140....--...150...-....160......--.170.......180....----...190.......200.......210--........220--.....-...--.230.......240.---......-----250.........260.......270....-...280.....----..-290-....---.....300........310.......320.......330.....----..340.....---..350...----.----.----..360.......370.......380.......390...-----....400----.........410-.......420....-----...430.......440.......450-.......460........470.......480..--.....490.......500.......510........520.......530......-.540.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSPTISHKDSSRQRR-------PGNFSHSLDMKSGPLPPGGWDD
S
H
LDSAGREGDREALLGDTGT
G
D
F
LKA
P
Q
S
F
R
A
E
L
S
S
I
L
L
L
L
F
L
Y
V
LQG----------IPLGLA-GS
I
P
L
I
L
QS-K-NV
S
Y
---
T
D
Q
A
F
-
F
S
F
V
F
W
P
F
S
L
-
K
L
L
W
A
P
L
--
V
D
A
-------
V
Y
V
--
K
N
FGRRKSWL
V
P
--
T
Q
Y
I
L
G
L
F
M
-
I
Y
L
S
T
Q
V
D
R
L
LGN--TDDRTP
D
V
I
A
L
T
V
A
F
F
L
F
----
E
F
L
A
A
T
QDIAVD
G
W
A
L
T
M
L
SRENVG---
Y
A
S
T
C
N
S
V
G
----
Q
T
A
G
Y
-
F
L
G
--
N
V
L
F
L
ALE
S
A
D
F
C
N
K
---
Y
LRFQP-----Q--PR
G
I
V
T
L
S
D
F
L
F
F
W
G
T
V
F
L
I
T
T
T
L
V
A
-
L
L
KKENEV
S
V
V
----
K
E
-
E
---TQG
I
---
T
D
T
Y
K
L
L
-
F
A
I
IK
M
P
A
V
L
T
F
C
L
L
I
L
T
A
KIGFS
A
A
D
A
V
T
G
L
K
L
V
E
----EGV
P
K
E
H
L
A
L
---
L
AV
P
M
V
P
L
----
Q
----
I
----
I
L
P
L
I
I
S
KYTAGP
Q
P
L
N
T
F
Y
KA
M
P
Y
R
L
L
L
GL
E
Y
A
L
L
V
W
-----WTPKV------EHQGG
F
P
I
Y
Y
Y
I
-
V
V
L
L
S
Y
A
L
H
Q
V
T
V
Y
-----
S
M
Y
V
S
I
M
AFNAKVSDPLI
G
G
T
Y
M
T
L
L
-
N
T
V
S
N
LGGN-WP
S
T
V
A
L
W
L
VDP
L
T
V
K
E
C
VGASN--QNCRT
P
D
A
V
E
L
C
K
K
LG
G
S
C
V
T
A
L
D
G
Y
-
Y
V
E
S
I
I
C
V
F
IG
F
G
W
W
F
FLGP
K
F
K
K
L
Q
DE-GSSS
W
K
CKRNN
15
Fugue
77.43
14%
-96
- C4 -
1EHK
5
COX1_THET8
A:
[14-562]
------
A
Y
P
E
K
K
A
T
L
Y
-------
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
---------------
Y
G
N
V
D
A
Y
P
L
L
K
R
L
L
P
F
V
Q
S
Y
Y
Q
G
L
T
L
H
G
V
L
N
A
I
V
----------
F
T
Q
L
F
A
-
Q
A
I
M
V
Y
L
P
A
-
R
-
E
L
N
M
RPN
M
G
L
M
W
-
L
S
W
W
M
A
F
I
G
L
-
V
V
A
A
L
P
L
--
L
A
N
EATVLYT
F
Y
P
--
P
L
K
G
H
W
A
F
Y
L
G
A
--
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
P
G
K
V
T
P
L
V
T
Y
M
A
V
V
F
W
L
M
----
W
F
L
A
S
L
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
G
L
V
E
---
G
V
D
--
P
L
V
A
----
R
T
L
F
W
-
W
T
G
H
P
I
V
Y
F
W
L
L
P
A
Y
A
I
I
Y
T
---
I
L
P
K
Q
A
----------
G
G
K
L
V
S
D
P
M
A
R
L
A
F
L
L
F
L
L
L
S
T
P
V
-
G
F
H
H
Q
F
A
D
P
G
I
----
D
P
-
T
---
W
K
M
I
---
H
S
V
L
T
L
F
-
V
A
V
P
S
L
M
T
A
F
T
V
A
A
S
L
E
F
A
G
R
L
R
G
G
R
G
L
F
G
W
I
R
A
L
P
----
W
D
N
P
A
F
V
A
P
V
---
L
G
L
L
G
F
I
P
----
G
----
G
----
A
G
G
I
V
N
A
S
F
T
L
D
Y
V
V
H
N
T
A
W
V
P
G
H
F
H
L
Q
V
A
S
L
V
T
L
T
A
M
G
S
L
YW
L
L
P
N
L
TG
K
P
I
S
D
A
Q
R
R
L
G
L
A
V
V
W
-
L
W
F
L
G
M
M
I
M
A
V
G
L
H
-----
W
A
G
L
L
N
V
P
R
R
A
Y
I
A
Q
V
P
D
A
Y
P
H
A
A
V
P
-
M
V
F
N
V
L
A
G
I
-
V
L
L
V
A
L
L
L
F
I
Y
G
L
--
F
S
V
L
L
S
R
L
--
A
E
A
P
L
P
F
A
E
V
I
S
G
P
E
D
R
R
L
V
L
A
M
D
R
I
G
F
W
F
A
V
A
A
I
L
V
V
L
A
Y
G
P
T
L
V
Q
L
F
G
H
L
N
P
V
P
G
W
R
L
W
------
14
Fugue
75.33
15%
-93
- C4 -
5C8T
-
?
B:
[2-526]
A
E
N
V
T
G
L
F
K
D
C
S
K
I
I
T
GLHPTQA
P
T
H
L
S
V
D
I
K
F
K
T
E
G
L
C
V
D
I
P
G
I
P
K
D
M
T
Y
R
R
L
I
S
M
M
G
F
K
M
N
Y
Q
V
N
G
Y
P
N
M
F
I
T
R
E
E
A
I
R
H
V
R
A
W
I
G
F
D
V
E
G
C
H
A
T
R
DAVGTN
L
P
L
Q
L
G
-
F
S
T
G
V
N
L
V
A
-
V
-
P
T
G
Y
---
V
D
T
E
N
-
N
T
E
F
T
R
V
N
A
K
-
P
------------------------
P
P
G
D
Q
F
K
H
L
I
P
--
L
M
Y
K
-
G
L
P
W
-
N
V
V
R
I
K
I
V
Q
M
L
S
D
--
T
L
K
G
L
S
D
R
V
V
F
V
L
W
A
H
G
F
----
E
L
T
S
M
K
Y
F
V
K
I
G
P
E
R
T
C
C
L
C
D
K
R
A
T
---
C
F
S
T
S
S
D
T
Y
A
C
WN
H
S
V
G
F
D
Y
V
Y
--
N
P
F
M
I
D
V
Q
Q
W
G
F
-
T
G
---
N
L
Q
S
N
H
-----
D
--
Q
H
C
Q
V
H
G
N
A
H
V
---
A
S
C
D
A
I
M
T
R
C
L
A
-
V
H
E
C
F
V
K
R
V
D
W
----
S
V
-
E
---
Y
P
I
I
---
G
D
E
L
R
V
N
-
S
A
C
R
K
V
Q
H
M
V
V
K
S
A
L
L
A
D
K
F
P
V
L
H
D
I
G
N
P
K
A
I
K
C
V
P
----
Q
---------------
A
E
V
E
W
----
K
----
F
----
Y
D
A
Q
P
C
S
D
K
A
Y
K
I
E
E
L
F
Y
S
Y
A
T
H
H
D
K
F
T
D
G
----
V
C
L
F
-----
W
N
C
N
V
------
D
R
---
Y
P
A
N
A
I
V
-
C
R
F
D
T
R
V
L
S
N
L
N
L
P
GCDGG
S
L
Y
V
N
K
H
A
F
H
T
P
A
F
D
-------
K
S
A
F
-
T
N
L
K
Q
L
P
F
F
-
Y
Y
S
D
S
P
C
E
Y
V
-
P
L
K
S
A
T
C
I
T
--------
R
C
N
L
G
G
A
V
C
R
H
H
A
N
E
Y
R
Q
Y
L
D
A
Y
-
N
M
M
I
S
A
----
G
F
S
L
W
I
Y
K
Q
F
D
T
Y
N
L
W
N
T
-
F
T
R
--------
20
Fugue
65.83
10%
-98
* C5 *
1PV6
-
LACY_ECOLI
A:
[1-417]
----------------------------------------------------------------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
----------
A
Y
F
P
F
----
F
P
I
W
L
H
D
-
I
-
N
--
H
---
I
S
K
S
D
-
T
G
I
I
F
A
A
I
S
L
-
F
S
L
L
F
Q
P
--
L
F
G
-------
L
L
S
--
D
K
L
G
L
R
K
---
Y
L
--
L
W
I
I
T
G
M
L
V
-
M
F
A
P
F
F
I
F
I
F
G
P
L
--
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
----
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
---
R
A
R
M
F
G
C
V
G
----
W
A
L
G
A
-
S
I
V
--
G
I
M
F
T
I
-------------------------------
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
A
K
T
D
A
P
S
S
A
T
----
V
A
-
N
---
A
V
G
A
NHS
A
F
S
L
K
L
A
-
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
----
F
F
A
T
G
E
Q
G
T
R
---
V
F
G
Y
V
T
T
M
----
G
----
E
----
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
-----
F
A
T
--------------
S
A
L
E
V
V
-
I
L
K
T
L
H
M
F
E
V
P
F
L
L
-----
V
G
C
F
K
Y
I
T
S
Q
--
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
-
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
--
L
V
A
L
G
F
T
L
I
S
V
F
T
-----------------------------------
L
S
G
P
G
P
L
-
S
L
L
R
R
Q
V
N
E
V
A
21
Fugue
65.63
17%
-75
- C2 -
4WW4
1
?
A:
[3-458]
-
Q
I
S
E
V
--
R
G
N
T
R
D
H
R
-------
T
A
A
H
T
H
I
K
G
L
G
-------------
L
N
S
S
G
--------
I
A
E
K
Q
A
A
G
F
V
G
Q
-
C
A
A
R
E
A
C
G
V
V
V
D
L
I
K
A
H
K
M
A
G
--------------------
R
G
V
L
L
A
-
G
-
G
P
G
T
---
G
K
T
A
L
-
A
L
A
I
S
Q
E
L
G
T
-
K
I
P
F
C
P
I
--
T
G
S
-------
E
I
Y
--
S
T
E
V
K
K
T
E
V
L
M
E
--
N
F
R
---------------
R
A
I
G
L
--
R
V
R
E
T
K
D
V
Y
E
G
E
V
S
T
L
L
I
----
G
L
K
S
A
R
------
G
Q
K
L
D
Q
K
E
R
V
Q
V
G
D
V
I
Y
I
E
T
N
T
G
A
C
----
R
S
D
A
Y
--------------
A
T
E
F
D
L
E
---
A
E
E
Y
V
P
-----
I
--
P
K
G
----------------------
E
-
V
H
K
K
K
E
I
V
Q
D
V
----
T
L
-
H
---
D
L
D
V
---
A
N
A
R
P
D
I
---
I
S
M
M
G
Q
L
M
K
P
K
M
T
E
I
T
D
K
L
R
M
E
I
N
K
V
V
Q
--
K
Y
I
N
----
Q
G
V
A
E
L
I
P
G
V
---
L
F
I
D
E
A
H
M
-----------------
L
D
I
E
C
F
T
Y
L
N
K
A
L
E
S
--
P
I
A
P
I
V
V
L
A
S
N
R
G
I
A
T
I
R
-----
G
A
D
D
L
------
K
A
A
H
G
I
P
P
D
F
L
Q
R
L
L
I
I
P
T
H
P
Y
E
P
D
E
I
-----
R
R
I
V
R
I
R
A
Q
T
E
G
V
Q
L
T
------
D
A
A
V
-
D
R
V
A
E
H
G
V
R
-
I
S
L
R
Y
C
L
Q
L
L
A
P
A
S
I
L
A
R
V
N
G
R
T
--
Q
------------------
V
D
V
Q
D
I
A
-
E
A
E
E
L
-----------
F
L
D
A
R
R
S
A
N
I
L
T
-
S
T
G
G
L
H
-----
26
HHSearch
64.53
13%
-109
- C5 -
2CFQ
-
LACY_ECOLI
A:
[8-379]
---------------------------------------------------------------------------------
N
F
W
M
F
G
L
F
F
F
F
Y
F
----------
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
-
I
N
H
I
S
K
---
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
--
S
D
K
-------
L
-------
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
-
F
I
F
I
F
G
P
-------------
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
IYL
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
---
F
E
F
G
R
A
R
M
F
----
G
C
V
G
W
-
A
L
G
--
A
S
I
V
G
I
M
F
T
---------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
-
F
A
K
T
D
A
P
S
S
A
T
----
V
A
-
N
AVG
A
N
H
S
---
A
F
S
L
K
L
A
-
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FAT
G
E
Q
G
T
R
V
F
G
Y
---
V
T
T
M
G
E
L
L
----
N
----
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
-
N
---
A
L
L
---
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
------
A
T
------------
S
-
A
L
-----
E
V
V
I
L
K
T
L
H
M
F
E
V
P
-----
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
--
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
-
V
N
E
V
A
-----------------------------------
22
HHSearch
60.37
13%
-120
- C5 -
1PW4
-
GLPT_ECOLI
A:
[25-413]
----------------------------------------------------------------------------
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
----------
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
E
-
Q
-
G
F
S
R
---
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
--
S
D
R
-------
S
-------
N
P
R
V
F
-
L
P
A
--
G
L
I
L
A
A
A
V
M
-
L
F
M
G
F
V
P
W
A
----------
T
S
S
I
A
V
M
F
V
L
L
F
L
C
----
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
---
G
I
V
S
V
W
N
C
A
----
H
N
V
G
G
-
G
I
P
--
P
L
L
F
L
L
G
M
A
W
-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
-
A
M
M
R
D
T
P
Q
S
C
G
LPPI
E
E
Y
K
---
N
D
------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V---
K
H
F
A
L
D
K
S
S
W
---
A
Y
F
L
Y
E
Y
A
----
G
I
P
G
T
L
----
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
-
T
G
V
---
F
F
M
T
L
V
T
I
A
T
I
-
V
Y
W
-----
M
N
P
A
-----------
G
N
P
T
-----
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
-----
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
--
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
-
E
L
V
P
------------------------------------
24
HHSearch
59.70
13%
-94
- C5 -
2GFP
-
EMRD_ECOLI
A:
[17-360]
-----------------------------------------------------------------------------------------
V
A
V
G
Q
----------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
-
L
-
N
V
R
E
---
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
--
S
D
R
-------
V
-------
G
R
R
P
V
-
I
L
V
--
G
M
S
I
F
M
L
A
T
-
L
V
A
V
T
T
--------------
S
S
L
T
V
L
I
A
A
S
A
M
Q
----
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
---
H
A
N
S
L
L
N
M
G
----
I
L
V
S
P
-
L
L
A
--
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
-
R
W
M
P
E
T
R
P
V
D
A
-------------
P
R
---
T
R
L
L
T
S
Y
-
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
---
L
G
L
S
S
M
T
V
S
I
---
L
F
I
L
P
I
P
A
----
A
----
F
----
F
G
A
W
F
A
G
R
P
N
K
R
-
F
S
T
L
M
W
Q
S
--
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
-----
W
F
G
V
-----------
M
N
V
----
W
-
T
L
L
V
P
A
A
L
F
F
F
G
A
G
-----
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
I
G
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
--
M
G
L
L
I
V
L
C
W
L
P
L
-------------------------------------------------------
23
HHSearch
56.02
12%
-119
- C5 -
3WDO
-
?
A:
[12-365]
----------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
----------
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
-
G
A
S
E
---
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
--
S
D
R
-------
I
-------
G
R
K
P
L
-
I
V
G
--
G
L
A
V
F
A
A
G
S
-
V
I
A
A
L
S
--------------
D
S
I
W
G
I
I
L
G
R
A
L
Q
----
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
---
K
A
M
A
F
I
G
V
S
----
F
G
I
T
F
-
A
I
A
--
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
-
W
V
V
P
N
S
S
T
H
V
L
----
N
R
-------
E
S
---
G
M
V
K
G
S
F
-
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
----
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
----
S
----
V
----
V
P
F
I
I
Y
A
E
V
K
R
K
-
M
K
Q
-
V
F
V
F
--
C
V
G
-
L
I
V
V
A
E
I
-
V
L
W
-----
N
A
Q
------------
T
Q
F
W
-----
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
-----
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
--
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
-
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
-
E
H
S
A
Y
V
K
I
D
S
K
25
HHSearch
54.23
11%
-112
- C5 -
3O7Q
1
FUCP_ECOLI
A:
[30-409]
------------------------------------------------------------------------------------
L
L
C
S
L
F
F
L
W
A
----------
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
-
F
-
T
L
T
N
---
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
--
M
K
K
-------
L
-------
S
Y
K
A
G
-
I
I
T
--
G
L
F
L
Y
A
L
G
A
-
A
L
F
W
P
A
A
E
-----------
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
----
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
---
F
R
L
N
L
A
Q
T
F
----
N
S
F
G
A
-
I
I
A
--
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
----
S
D
------
A
K
Q
---
G
S
F
S
A
S
L
-
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I--
P
G
M
T
A
G
F
A
A
N
---
Y
L
T
G
T
M
V
C
F
F
I
-
G
R
---
F
----
T
G
T
W
L
I
S
R
F
A
P
H
-
K
V
---
L
A
---
A
Y
A
L
I
A
M
A
-
L
C
L
I
S
A
-----
F
A
G
------------
G
-
H
V
-----
G
-
L
I
A
L
T
L
C
S
A
F
M
S
-----
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
--
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
--------------------------------------------------
28
HHSearch
36.77
9%
-113
- C5 -
3WDO
-
?
A:
[12-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L---
Q
G
A
S
E
A
L
I
G
I
---
A
I
G
I
Y
G
L
T
----
Q
A
V
F
Q
I
----
P
F
G
L
L
S
D
R
I
G
R
K
-
P
L
---
I
V
---
G
G
L
A
V
F
A
A
G
S
V
I
A
-
A
-----
L
S
D
------------
S
-
I
----
W
-
G
I
I
L
G
R
A
L
Q
G
S
G
-------
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
--
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
-
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
-
L
L
M
S
T
F
V
A
L
P
G
13
Fugue
35.62
17%
74
* C3 *
1NE5
-
KGX11_CENNO
A:
[1-42]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
D
S
C
V
D
K
S
R
C
A
K
Y
G
Y
Y
Q
E
C
Q
D
C
C
K
N
A
G
H
N
G
G
T
C
M
F
F
K
-
C
K
C
A
------------------------------------
31
HHSearch
33.58
12%
-80
- C5 -
3O7Q
1
FUCP_ECOLI
A:
[37-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
----
F
T
L
T
N
F
Q
A
G
L
---
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
----
I
----
P
A
G
I
L
M
K
K
L
S
Y
K
-
A
G
---
I
I
---
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
------
A
A
E
------------
I
M
N
--
Y
T
-
L
F
L
V
G
L
F
I
I
A
A
G
L
G
-----
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
--
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
-
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
-
G
S
F
S
A
S
L
S
R
L
A
2
PsiBlast_PDB
32.42
27%
-50
- C6 -
3T4N
-
A:
[51-135]
---------------------------------------------------------------------------------------------------------------------------------------------
W
H
F
G
I
-
R
S
R
S
Y
P
L
D
V
M
G
E
-------
I
Y
I
A
L
K
N
L
G
--
A
E
W
A
K
P
--
S
E
E
--
D
L
W
T
-
I
K
L
R
W
K
Y
------------
I
P
D
L
M
K
M
V
I
Q
L
F
Q
I
----
E
T
N
N
Y
L
V
D
F
K
F
D
G
W
E
S
S
T
F
S
A
Y
P
F
L
---
H
L
T
T
K
L
I
M
E
----
L
A
V
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
31.99
27%
-49
- C6 -
3TDH
-
A:
[51-135]
---------------------------------------------------------------------------------------------------------------------------------------------
W
H
F
G
I
-
R
S
R
S
Y
P
L
D
V
M
G
E
-------
I
Y
I
A
L
K
N
L
G
--
A
E
W
A
K
P
--
S
E
E
--
D
L
W
T
-
I
K
L
R
W
K
Y
------------
I
P
D
L
M
K
M
V
I
Q
L
F
Q
I
----
E
T
N
N
Y
L
V
D
F
K
F
D
G
W
E
S
S
T
F
S
A
Y
P
F
L
---
H
L
T
T
K
L
I
M
E
----
L
A
V
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
31.44
27%
-51
- C6 -
3TE5
-
A:
[51-135]
---------------------------------------------------------------------------------------------------------------------------------------------
W
H
F
G
I
-
R
S
R
S
Y
P
L
D
V
M
G
E
-------
I
Y
I
A
L
K
N
L
G
--
A
E
W
A
K
P
--
S
E
E
--
D
L
W
T
-
I
K
L
R
W
K
Y
------------
I
P
D
L
M
K
M
V
I
Q
L
F
Q
I
----
E
T
N
N
Y
L
V
D
F
K
F
D
G
W
E
S
F
S
A
Y
P
F
L
H
L
---
T
T
K
L
I
M
E
L
A
----
V
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
31.24
27%
-43
* C6 *
2QLV
-
SNF1_YEAST
A:
[505-589]
---------------------------------------------------------------------------------------------------------------------------------------------
W
H
F
G
I
-
R
S
R
S
Y
P
L
D
V
M
G
E
-------
I
Y
I
A
L
K
N
L
G
--
A
E
W
A
K
P
--
S
-----
L
W
T
-
I
K
L
R
W
K
---------------
D
L
M
K
M
V
I
Q
L
F
Q
-------
N
N
Y
L
V
D
F
K
F
D
G
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.90
32%
-24
- C3 -
4L1Y
1
?
A:
[21-83]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
L
E
E
L
L
G
L
--
N
S
G
E
T
P
D
V
I
A
V
A
V
Q
G
F
G
F
----
Q
T
D
K
P
Q
Q
G
P
A
C
V
K
N
F
Q
S
L
L
T
S
K
--
G
---
Y
T
K
L
K
N
T
I
T
----
E
T
M
G
L
-
T
V
Y
--
C
L
E
K
H
L
D
Q
N
T
L
K
N
E
T
---
I
I
V
T
V
D
-----
D
--
Q
K
K
S
G
G
I
V
T
S
F
T
I
Y
N
K
R
F
S
F
T
T
S
R
M
S
-
D
E
D
V
T
S
T
N
T
K
Y
----
A
Y
-
D
---
T
R
L
D
---
Y
S
K
K
D
D
P
-
S
D
F
L
F
W
I
G
D
L
N
V
R
V
E
T
N
A
T
H
A
K
S
L
V
D
Q
N
N
I
D
G
L
M
A
F
----
D
Q
L
K
K
A
K
E
Q
K
---
L
F
D
G
W
T
E
P
----
Q
----
V
----
T
F
K
P
T
Y
K
F
K
P
N
T
D
E
Y
D
L
S
A
T
P
S
W
T
D
R
A
L
Y
K
S
G
T
G
K
T
I
Q
-----
P
L
S
Y
N
------
S
L
T
N
Y
K
Q
T
E
H
R
P
-
V
L
A
K
F
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
30.81
32%
-23
- C3 -
1Y21
3
?
A:
[23-85]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
L
E
E
L
L
G
L
--
N
S
G
E
T
P
D
V
I
A
V
A
V
Q
G
F
G
F
----
Q
T
D
K
P
Q
Q
G
P
A
C
V
K
N
F
Q
S
L
L
T
S
K
--
G
---
Y
T
K
L
K
N
T
I
T
----
E
T
M
G
L
-
T
V
Y
--
C
L
E
K
H
L
D
Q
N
T
L
K
N
E
T
---
I
I
V
T
V
D
-----
D
--
Q
K
K
S
G
G
I
V
T
S
F
T
I
Y
N
K
R
F
S
F
T
T
S
R
M
S
-
D
E
D
V
T
S
T
N
T
K
Y
----
A
Y
-
D
---
T
R
L
D
---
Y
S
K
K
D
D
P
-
S
D
F
L
F
W
I
G
D
L
N
V
R
V
E
T
N
A
T
H
A
K
S
L
V
D
Q
N
N
I
D
G
L
M
A
F
----
D
Q
L
K
K
A
K
E
Q
K
---
L
F
D
G
W
T
E
P
----
Q
----
V
----
T
F
K
P
T
Y
K
F
K
P
N
T
D
E
Y
D
L
S
A
T
P
S
W
T
D
R
A
L
Y
K
S
G
T
G
K
T
I
Q
-----
P
L
S
Y
N
------
S
L
T
N
Y
K
Q
T
E
H
R
P
-
V
L
A
K
F
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
30.69
32%
-23
- C3 -
1SI6
2
?
X:
[23-85]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
L
E
E
L
L
G
L
--
N
S
G
E
T
P
D
V
I
A
V
A
V
Q
G
F
G
F
----
Q
T
D
K
P
Q
Q
G
P
A
C
V
K
N
F
Q
S
L
L
T
S
K
--
G
---
Y
T
K
L
K
N
T
I
T
----
E
T
M
G
L
-
T
V
Y
--
C
L
E
K
H
L
D
Q
N
T
L
K
N
E
T
---
I
I
V
T
V
D
-----
D
--
Q
K
K
S
G
G
I
V
T
S
F
T
I
Y
N
K
R
F
S
F
T
T
S
R
M
S
-
D
E
D
V
T
S
T
N
T
K
Y
----
A
Y
-
D
---
T
R
L
D
---
Y
S
K
K
D
D
P
-
S
D
F
L
F
W
I
G
D
L
N
V
R
V
E
T
N
A
T
H
A
K
S
L
V
D
Q
N
N
I
D
G
L
M
A
F
----
D
Q
L
K
K
A
K
E
Q
K
---
L
F
D
G
W
T
E
P
----
Q
----
V
----
T
F
K
P
T
Y
K
F
K
P
N
T
D
E
Y
D
L
S
A
T
P
S
W
T
D
R
A
L
Y
K
S
G
T
G
K
T
I
Q
-----
P
L
S
Y
N
------
S
L
T
N
Y
K
Q
T
E
H
R
P
-
V
L
A
K
F
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
30.34
27%
109
- C3 -
2JWH
-
VSI4_TRYBB
A:
[421-468]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
K
A
S
K
S
G
-
V
P
V
T
Q
T
Q
T
A
G
A
D
T
T
A
E
K
C
K
G
K
G
E
--
K
D
C
K
S
P
D
----
C
K
W
E
G
G
T
C
K
D
----------------------------------------------