@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADT2_HUMAN: (2015-12-07 )
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
Atome Classification :
(20 SA)
---------------------------------------------------------------.....-----....10........20......-------..30...------.....-40..---...---...50--------------........60..-------...-----...-70.------.....---..80.------.-----------...----...90-.........100----......----.--..110.----......120....----...130-........140------.-----.--.------....150....--------.--..160......--------.-170.......180-.....---------...-------------.190..---------.....------200......--..---------210---.....----...220-----.....------...230...-----------------------....240-------........250-----------...------------....260.--------...------...270.....--------..280.--.----......290......-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MT
D
A
A
-----
V
S
F
A
K
D
F
L
A
G
G
V
A
A
A
I
S
K
TAVA-------
P
I
E
R
V
K
L
------
L
L
Q
V
Q-HASK---QIT---A
D
K
Q
Y
--------------
K
G
I
I
D
C
V
V
RIPK-------EQ
G
-----
V
L
S
-
F
W
R
------
G
N
L
A
N
---
V
I
R
YF------P-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
Y
K
Q
I
F
L------GGVDK
R
----
T
--
Q
F
W
L
Y
F----AGNLASGGAAGA
T
----
S
L
C
F
V
--YPL
D
F
A
R
T
R
L
A
------
A
-----
D
--V------GKAGA
E
R
E
F
R
G
--------
L
--
G
D
C
L
V
K
I
Y
KSD--------G-
I
K
G
L
Y
QGF
N
V
S
---
V
Q
G
I
I
---------
I
Y
R
-------------
A
A
Y
F
G
I
---------YDTAK------GM-LPDPKN--
T
H
---------
I
V
----
I
S
W
M
I
----
A
Q
T
V
T
------
A
V
AGL------TSY
P
F
D
T
V
R
-----------------------
R
R
M
M
M
Q--------SGRKG
T
D
I
M
Y
T-----------G
T
L
------------
D
C
W
R
K
I
A
R--------DEG------G
K
A
F
F
K
G
A
W
S
N
--------
V
L
R
-GM--G----
G
A
F
V
L
V
L
Y
D
E
I
K
KYT-----------
22
Fugue
87.70
90%
-84
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------------------------------------------
D
Q
A
-----
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
-------
P
I
E
R
V
K
L
------
L
L
Q
V
Q
-
H
A
S
K
---
Q
I
S
---
A
E
K
Q
Y
--------------
K
G
I
I
D
C
V
V
R
I
P
K
-------
E
Q
G
-----
F
L
S
-
F
W
R
------
G
N
L
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
Y
K
Q
I
F
L
------
G
G
V
D
R
H
----
K
--
Q
F
W
R
Y
F
----
A
G
N
L
A
S
G
G
A
A
G
A
T
----
S
L
C
F
V
--
Y
P
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
V
------
G
K
G
A
A
Q
R
E
F
T
G
--------
L
--
G
N
C
I
T
K
I
F
K
S
D
--------
G
-
L
R
G
L
Y
Q
G
F
N
V
S
---
V
Q
G
I
I
---------
I
Y
R
-------------
A
A
Y
F
G
V
---------
Y
D
T
A
K
------
G
M
-
L
P
D
P
K
N
--
V
H
---------
I
I
----
V
S
W
M
I
----
A
Q
T
V
T
------
A
V
A
G
L
------
V
S
Y
P
F
D
T
V
R
-----------------------
R
R
M
M
M
Q
--------
S
G
R
K
G
A
D
I
M
Y
T
-----------
G
T
V
------------
D
C
W
R
K
I
A
K
--------
D
E
G
------
P
K
A
F
F
K
G
A
W
S
N
--------
V
L
R
-
G
M
--
G
----
G
A
F
V
L
V
L
Y
D
E
I
---------------
12
HHSearch
87.70
90%
-84
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------------------------------------------
D
Q
A
-----
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
-------
P
I
E
R
V
K
L
------
L
L
Q
V
Q
-
H
A
S
K
---
Q
I
S
---
A
E
K
Q
Y
--------------
K
G
I
I
D
C
V
V
R
I
P
K
-------
E
Q
G
-----
F
L
S
-
F
W
R
------
G
N
L
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
Y
K
Q
I
F
L
------
G
G
V
D
R
H
----
K
--
Q
F
W
R
Y
F
----
A
G
N
L
A
S
G
G
A
A
G
A
T
----
S
L
C
F
V
--
Y
P
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
V
------
G
K
G
A
A
Q
R
E
F
T
G
--------
L
--
G
N
C
I
T
K
I
F
K
S
D
--------
G
-
L
R
G
L
Y
Q
G
F
N
V
S
---
V
Q
G
I
I
---------
I
Y
R
-------------
A
A
Y
F
G
V
---------
Y
D
T
A
K
------
G
M
-
L
P
D
P
K
N
--
V
H
---------
I
I
----
V
S
W
M
I
----
A
Q
T
V
T
------
A
V
A
G
L
------
V
S
Y
P
F
D
T
V
R
-----------------------
R
R
M
M
M
Q
--------
S
G
R
K
G
A
D
I
M
Y
T
-----------
G
T
V
------------
D
C
W
R
K
I
A
K
--------
D
E
G
------
P
K
A
F
F
K
G
A
W
S
N
--------
V
L
R
-
G
M
--
G
----
G
A
F
V
L
V
L
Y
D
E
I
---------------
1
PsiBlast_PDB
87.48
89%
-84
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------------------------------------------
D
Q
A
-----
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
-------
P
I
E
R
V
K
L
------
L
L
Q
V
Q
-
H
A
S
K
---
Q
I
S
---
A
E
K
Q
Y
--------------
K
G
I
I
D
C
V
V
R
I
P
K
-------
E
Q
G
-----
F
L
S
-
F
W
R
------
G
N
L
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
Y
K
Q
I
F
L
------
G
G
V
D
R
H
----
K
--
Q
F
W
R
Y
F
----
A
G
N
L
A
S
G
G
A
A
G
A
T
----
S
L
C
F
V
--
Y
P
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
V
------
G
K
G
A
A
Q
R
E
F
T
G
--------
L
--
G
N
C
I
T
K
I
F
K
S
D
--------
G
-
L
R
G
L
Y
Q
G
F
N
V
S
---
V
Q
G
I
I
---------
I
Y
R
-------------
A
A
Y
F
G
V
---------
Y
D
T
A
K
------
G
M
-
L
P
D
P
K
N
--
V
H
---------
I
I
----
V
S
W
M
I
----
A
Q
T
V
T
------
A
V
A
G
L
------
V
S
Y
P
F
D
T
V
R
-----------------------
R
R
M
M
M
Q
--------
S
G
R
K
G
A
D
I
M
Y
T
-----------
G
T
V
------------
D
C
W
R
K
I
A
K
--------
D
E
G
------
P
K
A
F
F
K
G
A
W
S
N
--------
V
L
R
-
G
M
--
G
----
G
A
F
V
L
V
L
Y
D
E
I
---------------
2
PsiBlast_PDB
86.80
89%
-83
- C4 -
2C3E
4
ADT1_BOVIN
A:
[1-293]
----------------------------------------------------------------
S
D
Q
A
-----
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
-------
P
I
E
R
V
K
L
------
L
L
Q
V
Q
-
H
A
S
K
---
Q
I
S
---
A
E
K
Q
Y
--------------
K
G
I
I
D
C
V
V
R
I
P
K
-------
E
Q
G
-----
F
L
S
-
F
W
R
------
G
N
L
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
Y
K
Q
I
F
L
------
G
G
V
D
R
H
----
K
--
Q
F
W
R
Y
F
----
A
G
N
L
A
S
G
G
A
A
G
A
T
----
S
L
C
F
V
--
Y
P
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
V
------
G
K
G
A
A
Q
R
E
F
T
G
--------
L
--
G
N
C
I
T
K
I
F
K
S
D
--------
G
-
L
R
G
L
Y
Q
G
F
N
V
S
---
V
Q
G
I
I
---------
I
Y
R
-------------
A
A
Y
F
G
V
---------
Y
D
T
A
K
------
G
M
-
L
P
D
P
K
N
--
V
H
---------
I
I
----
V
S
W
M
I
----
A
Q
T
V
T
------
A
V
A
G
L
------
V
S
Y
P
F
D
T
V
R
-----------------------
R
R
M
M
M
Q
--------
S
G
R
K
G
A
D
I
M
Y
T
-----------
G
T
V
------------
D
C
W
R
K
I
A
K
--------
D
E
G
------
P
K
A
F
F
K
G
A
W
S
N
--------
V
L
R
-
G
M
--
G
----
G
A
F
V
L
V
L
Y
D
E
I
---------------
10
PsiBlast_CBE
77.51
54%
-74
- C4 -
4C9J
5
ADT3_YEAST
B:
[27-313]
---------------------------------------------------------------------------
F
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
-------
P
I
E
R
V
K
I
------
L
I
Q
N
Q
D
E
M
I
K
---
Q
G
T
---
L
D
K
K
Y
--------------
S
G
I
V
D
C
F
K
R
T
A
K
-------
Q
E
G
-----
L
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
L
M
F
--------
G
---------------
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
A
K
S
----
S
----
A
R
Q
F
N
G
--------
L
--
T
D
V
Y
K
K
T
L
K
S
D
--------
G
-
I
A
G
L
Y
R
G
F
M
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
F
D
S
L
-------------------------------------
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
N
-----------
G
A
I
------------
D
C
L
K
K
I
V
A
--------
S
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
S
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
-----------
9
PsiBlast_CBE
74.59
54%
-72
- C4 -
4C9Q
5
ADT3_YEAST
B:
[25-313]
-------------------------------------------------------------------------
T
N
F
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
-------
P
I
E
R
V
K
I
------
L
I
Q
N
Q
D
E
M
I
K
---
Q
G
T
---
L
D
K
K
Y
--------------
S
G
I
V
D
C
F
K
R
T
A
K
-------
Q
E
G
-----
L
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
L
M
F
--------
G
F
K
K
E
----
E
--
G
Y
G
K
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
A
-----------
A
R
Q
F
N
G
--------
L
--
T
D
V
Y
K
K
T
L
K
S
D
--------
G
-
I
A
G
L
Y
R
G
F
M
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
F
D
S
L
K
------
P
L
V---------
S
---------
F
L
----
A
S
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
N
-----------
G
A
I
------------
D
C
L
K
K
I
V
A
--------
S
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
S
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
-----------
3
PsiBlast_PDB
74.57
54%
-72
- C4 -
4C9J
4
ADT3_YEAST
A:
[25-313]
-------------------------------------------------------------------------
T
N
F
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
-------
P
I
E
R
V
K
I
------
L
I
Q
N
Q
D
E
M
I
K
---
Q
G
T
---
L
D
K
K
Y
--------------
S
G
I
V
D
C
F
K
R
T
A
K
-------
Q
E
G
-----
L
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
L
M
F
--------
G
F
K
K
E
----
E
--
G
Y
G
K
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
A
KS---------
A
R
Q
F
N
G
--------
L
--
T
D
V
Y
K
K
T
L
K
S
D
--------
G
-
I
A
G
L
Y
R
G
F
M
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
F
D
S
L
K
------------------------------------
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
N
-----------
G
A
I
------------
D
C
L
K
K
I
V
A
--------
S
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
S
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
-----------
4
PsiBlast_PDB
74.53
54%
-72
- C4 -
4C9Q
5
ADT3_YEAST
A:
[25-313]
-------------------------------------------------------------------------
T
N
F
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
-------
P
I
E
R
V
K
I
------
L
I
Q
N
Q
D
E
M
I
K
---
Q
G
T
---
L
D
K
K
Y
--------------
S
G
I
V
D
C
F
K
R
T
A
K
-------
Q
E
G
-----
L
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
L
M
F
--------
G
F
K
K
E
-------
G
Y
G
K
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
F
A
R
T
R
L
A
------
A
-----
D
--
A
KS---------
A
R
Q
F
N
G
--------
L
--
T
D
V
Y
K
K
T
L
K
S
D
--------
G
-
I
A
G
L
Y
R
G
F
M
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
F
D
S
L
K
------
P
L
--------------------
F
L
----
A
S
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
N
-----------
G
A
I
------------
D
C
L
K
K
I
V
A
--------
S
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
S
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
-----------
11
PsiBlast_CBE
73.39
54%
-68
- C4 -
4C9H
5
ADT2_YEAST
B:
[24-309]
----------------------------------------------------------------------------
L
I
D
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
-------
P
I
E
R
V
K
L
------
L
I
Q
N
Q
D
E
M
L
K
---
Q
G
T
---
L
D
R
K
Y
--------------
A
G
I
L
D
C
F
K
R
T
A
T
-------
Q
E
G
-----
V
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
A
M
F
--------
G
F
K
K
E
----
E
--
G
Y
A
K
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
Y
A
R
T
R
L
A
------
A
-----
D
SK-----------
G
A
R
Q
F
N
G
--------
L
--
I
D
V
Y
K
K
T
L
K
S
D
--------
G
-
V
A
G
L
Y
R
G
F
L
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
Y
D
S
L
K
-----------------------------
L
----
A
S
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
D
-----------
G
A
F
------------
D
C
L
R
K
I
V
A
--------
A
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
G
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
--------------
5
PsiBlast_PDB
70.45
54%
-70
- C4 -
4C9H
5
ADT2_YEAST
A:
[22-309]
--------------------------------------------------------------------------
N
F
L
I
D
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
-------
P
I
E
R
V
K
L
------
L
I
Q
N
Q
D
E
M
L
K
---
Q
G
T
---
L
D
R
K
Y
--------------
A
G
I
L
D
C
F
K
R
T
A
T
-------
Q
E
G
-----
V
I
S
-
F
W
R
------
G
N
T
A
N
---
V
I
R
Y
F
------
P
-----------
T
Q
A
----
L
N
F
A
--
F
K
D
K
I
K
A
M
F
--------
G
F
K
K
E
----
E
--
G
Y
A
K
W
F
----
A
G
N
L
A
S
G
G
A
A
G
A
L
----
S
L
L
F
V
--
Y
S
L
D
Y
A
R
T
R
L
A
------
A
-----
D
S-------------
A
R
Q
F
N
G
--------
L
--
I
D
V
Y
K
K
T
L
K
S
D
--------
G
-
V
A
G
L
Y
R
G
F
L
P
S
---
V
V
G
I
V
---------
V
Y
R
-------------
G
L
Y
F
G
M
---------
Y
D
S
L
K
-----------------------------
L
----
A
S
F
L
L
----
G
W
V
V
T
------
T
G
A
S
T
------
C
S
Y
P
L
D
T
V
R
-----------------------
R
R
M
M
M
T
--------
S
G
Q
A
---
V
K
Y
D
-----------
G
A
F
------------
D
C
L
R
K
I
V
A
--------
A
E
G
------
V
G
S
L
F
K
G
C
G
A
N
--------
I
L
R
-
G
V
--
A
----
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
-----------
23
Fugue
54.99
22%
-87
- C2 -
4J1Q
1
A:
[20-445]
H
M
E
R
L
M
L
E
P
V
WEKQNEELSYT
E
H
I
I
V
L
F
ETE
R
S
V
T
D
S
I
A
S
H
M
KD
A
R
V
I
T
L
NEAVGH
I
A
E
R
Y
Q
C
Y
M
Q
N
I
-----
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
R
I
I
I
Q
A
I
V
-------
P
L
E
K
E
K
Q
------
L
F
A
G
V
-
S
G
L
F
---
K
-
T
---
A
E
I
E
F
--------------
S
K
L
T
A
Q
V
I
E
I
E
K
PEEMID
L
H
L
K
-----
L
K
D
-
D
S
R
------
R
P
F
D
K
---
Q
I
R
Y
E
------
A
G
Y
R
F
V
K
G
W
R
E
M
V
D
T
----
L
H
M
P
--
W
R
D
E
G
V
Y
L
I
T
------
G
G
---
A
----
G
--
S
L
G
L
L
F
----
A
K
E
I
A
N
R
T
--
G
R
S
----
T
I
V
L
T
G
R
S
V
L
S
E
D
K
E
N
E
L
------
E
-----
A
--
L
------
R
S
I
G
A
E
V
V
Y
R
E
ADVSD
Q
H
A
V
--
R
H
L
L
E
E
I
K
E
R
Y
--------
G
T
L
N
G
I
I
H
G
A
G
S
S
---
K
D
R
F
I
---------
I
H
K
T
N
E
E
F
Q
E
V
L
QPK
V
S
G
L
L
H
V
---------
D
E
C
S
K
------
D
F
----
P
L
D
--
F
F
---------
I
F
----
F
S
S
V
S
----
G
C
L
G
N
AGQ
A
D
Y
A
A
A
N
S
------
F
M
D
A
F
A
E
Y
R
-----------------------
R
S
L
A
A
S
--------
K
K
R
F
G
S
T
I
S
F
N
WPLWEEGGMQV
G
A
E
------------
D
E
K
R
M
L
K
T
T
GMVPMP
T
D
S
G
------
L
K
A
F
Y
Q
G
I
V
S
D
---------------------
K
P
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
LL-------
24
Fugue
54.22
15%
-75
* C3 *
1WKV
1
CYSO_AERPE
A:
[2-383]
-----------------------------------------------------ALADISGYLD
V
L
D
S
V
RGF
S
Y
L
E
N
A
R
E
V
L
R
S
G
E
A
R
C
L
G
N
-
P
R
S
-------
E
P
E
Y
V
K
A
------
L
Y
V
I
G
-
A
S
R
I
---
P
V
G
---
D
G
C
S
H
T
LEELGVFDISVPG
E
M
V
F
P
S
P
L
D
F
F
E
-------
R
G
K
-----
P
T
P
-
L
V
R
S
R
L
Q
L
P
N
G
V
R
V
---
W
L
K
L
E
------
W
-----------
Y
N
P
----
F
S
L
S
--
V
K
D
R
P
A
V
E
I
I
------
S
R
L
S
R
R
VEKG
S
--
L
V
A
D
A
T
----
S
S
N
F
G
V
A
L
S
A
V
A
R
L
Y
G
Y
R
A
R
V
Y
--
L
P
G
A
A
E
E
F
G
K
L
LPRLLG
A
-----
Q
--
V
------
I
V
D
P
E
A
P
S
T
V
H
--------
L
--
L
P
R
V
M
K
D
S
K
N
E
--------
G
-
F
V
H
V
N
Q
F
Y
N
-
D
---
A
N
F
E
A
---------
H
M
R
-------------
G
T
A
R
E
I
---------
F
V
Q
S
R
------
R
---
G
G
L
A
L
--
R
G
---------
V
A
----
G
S
L
G
T
----
S
G
H
M
S
------
A
A
A
F
Y
------
L
Q
S
V
D
P
S
I
R
A
V
L
V
Q
PAQGDSIPGIRRVETGML
W
I
N
M
L
D
--------
I
S
Y
T
L
A
E
V
T
L
E
-----------
E
A
M
------------
E
A
V
V
E
V
A
R
--------
S
D
G
L
V
I
G
P
S
G
G
A
A
V
K
A
L
A
K
K
--------
A
A
E
-
G
D
LE
P
----
G
D
Y
V
V
V
V
P
D
T
G
F
K
Y
L
S
L
V
Q
N
A
L
E---
14
HHSearch
50.76
24%
-51
- C4 -
1OKC
9
ADT1_BOVIN
A:
[111-293]
--------------------------------------------------------------------------
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
-------
P
L
D
F
A
R
T
------
R
L
A
A
D
-
V
G
K
G
---
A
-----
A
Q
R
E
F
--------------
T
G
L
G
N
C
I
T
K
I
F
K
-------
S
D
G
-----
L
R
G
-
L
Y
Q
------
G
F
N
V
S
---
V
Q
G
I
I
------
I
-----------
Y
R
A
----
A
Y
F
G
--
V
Y
D
T
A
K
G
M
L
P
------
D
P
K
N
------------
V
H
I
----
I
V
S
W
M
I
A
Q
T
V
T
A
V
----
A
G
L
V
S
--
Y
P
F
D
T
V
R
R
R
M
M
------
M
-----
Q
--
S
------
G
R
K
G
A
D
I
M
Y
T
G
--------
T
--
V
D
C
W
R
K
I
A
K
D
E
--------
G
-
P
K
A
F
F
K
G
A
W
S
N
---
V
L
R
G
M
---------
G
-
G
-------------
A
F
V
L
V
L
---------
Y
D
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.91
24%
-55
- C4 -
2LCK
-
UCP2_MOUSE
A:
[17-296]
-------------------------------------------------------------------------------
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
F
-------
P
L
D
T
A
K
V
------
R
L
Q
I
Q
-
G
E
S
Q
G
L
V
R
T
A
---
A
S
A
Q
Y
--------------
R
G
V
L
G
T
I
L
T
M
V
R
-------
T
E
G
-----
P
R
S
-
L
Y
N
------
G
L
V
A
G
---
L
Q
R
Q
M
------
S
-----------
F
A
S
----
V
R
I
G
--
L
Y
D
S
V
K
Q
F
Y
T
------
K
G
S
E
H
A
----
G
-------
I
----
G
S
R
L
L
A
G
S
T
T
G
A
L
----
A
V
A
V
A
--
Q
P
T
D
V
V
K
V
R
F
Q
------
A
-----
Q
---------
A
R
A
G
G
G
R
R
Y
Q
S
--------
T
--
V
E
A
Y
K
T
I
A
R
E
E
--------
G
-
I
R
G
L
W
K
G
T
S
P
N
---
V
A
R
N
A
---------
I
V
N
-------------
C
A
E
L
V
T
---------
Y
D
L
I
K
D
T
LLKA
N
L
-
M
T
D
D
L
P
--
C
H
---------
F
T
----
S
A
F
G
A
----
G
F
C
T
T
------
V
I
A
S
----------
P
V
D
V
V
K
-----------------------
T
R
Y
M
N
S
--------
A
L
G
Q
-----
Y
H
-----------
S
A
G
------------
H
C
A
L
T
M
L
R
--------
K
E
G
------
P
R
A
F
Y
K
G
F
M
P
S
--------
F
L
R
L
G
S
--
W
----
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
-----------
26
Fugue
48.17
21%
-67
- C1 -
1CJD
-
CAPSD_BPPRD
A:
[15-383]
----------------------------------------------------------------
L
R
N
Q
-----
Q
A
M
A
A
N
L
Q
A
R
Q
I
V
L
Q
Q
S
Y
P
V
I
Q
-------
Q
V
E
T
Q
T
F
D
PANRS
V
F
D
V
T
-
P
A
N
V
---
G
I
V
---
K
G
F
L
V
--------------
K
V
T
A
A
I
T
N
N
H
A
T
-------
E
A
V
-----
A
L
T
D
F
G
P
------
A
N
L
V
Q
---
R
V
I
Y
Y
D
PDNQR
H
-----------
T
E
T
S
G
W
H
L
H
F
V
--
N
T
A
K
Q
G
A
P
F
L
S
S
M
V
T
D
S
P
I
K
Y
G
----
D
--
V
M
N
V
I
D
----
A
P
A
T
I
A
A
G
A
T
G
E
L
----
T
M
Y
Y
W
--
V
P
L
A
Y
S
E
T
D
L
T
------
G
-----
A
--
V
LANVPQ
S
K
Q
R
L
K
L
E
F
A
N
--------
N
--
N
T
A
F
A
A
V
-
G
A
N
--------
P
-
L
E
A
I
Y
Q
G
A
G
A
A
---
D
---
C
---------
E
F
E
-------------
E
I
S
Y
T
V
---------
Y
Q
S
Y
L
------
D
Q
-
L
P
V
G
Q
N
--
G
Y
---------
I
L
P
L
I
D
L
S
T
L
Y
----
N
L
E
N
S
------
A
Q
A
G
L
------
T
P
N
V
D
F
V
V
Q
Y
A
N
L-------------------
Y
R
Y
L
S
T
I
A
V
FDNGG
S
F
N
A
G
T
D
I
N
Y
L
-----------
S
Q
R
T
ANFSDTRKLD
P
K
T
W
A
A
Q
T
R
--------
R
R
I
------
A
T
D
F
P
K
G
V
Y
Y
C
D
NRDKPIY
T
L
Q
-
Y
G
--
N
----
V
G
F
V
V
N
P
K
T
V
N
Q
N
A
R
L
L
M
G
Y
E
Y
F
T
S
R
13
HHSearch
43.91
24%
-52
- C4 -
2LCK
-
UCP2_MOUSE
A:
[14-297]
----------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
F
-------
P
L
D
T
A
K
V
------
R
L
Q
I
Q
-
G
E
S
Q
---
G
L
V
R
T
A
A
S
A
Q
Y
--------------
R
G
V
L
G
T
I
L
T
M
V
R
-------
T
E
G
-----
P
R
S
-
L
Y
N
------
G
L
V
A
G
---
L
Q
R
Q
M
------
S
-----------
F
A
S
----
V
R
I
G
--
L
Y
D
S
V
K
Q
F
Y
T
------
K
G
S
E
-----------
H
A
G
I
----
G
S
R
L
L
A
G
S
T
T
G
A
L
----
A
V
A
V
A
--
Q
P
T
D
V
V
K
V
R
F
Q
------
A
-----
Q
--
A
------
R
A
G
-
G
G
R
R
Y
Q
S
--------
T
--
V
E
A
Y
K
T
I
A
R
E
E
--------
G
-
I
R
G
L
W
K
G
T
S
P
N
---
V
A
R
N
A
---------
I
V
N
-------------
C
A
E
L
V
T
---------
Y
D
L
I
K
------
D
T
-
L
L
K
A
N
L
MT
D
D
---------
L
P
----
C
H
F
T
S
----
A
F
G
A
G
------
F
C
T
T
V
------
I
A
S
P
V
D
V
V
K
-----------------------
T
R
Y
M
N
S
--------
A
L
G
-----
Q
Y
H
-----------
S
A
G
------------
H
C
A
L
T
M
L
R
--------
K
E
G
------
P
R
A
F
Y
K
G
F
M
P
S
--------
F
L
R
-
L
G
--
S
W
---
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
-----------
28
Fugue
43.48
21%
-68
- C3 -
1ZY7
1
RED1_HUMAN
A:
[8-402]
----------------------------------------------------------SR
Q
P
I
P
S
E
G
L
-----
Q
L
H
L
P
Q
V
L
A
D
A
V
S
R
L
V
L
G
K
F
G
D
L
T
D
NFSS
P
H
A
R
R
K
V
------
L
A
G
V
V
-
M
T
T
G
---
T
D
V
---
K
D
A
K
V
--------------
I
S
V
S
T
G
T
K
C
I
N
G
-------
E
Y
M
SDRGL
A
L
N
-
D
C
H
------
A
E
I
I
S
R
R
S
L
L
R
F
L
------
Y
-----------
T
Q
L
----
E
L
Y
L
NN
K
D
D
Q
K
R
S
I
F
Q
KSER--
G
G
F
R
L
K
----
E
N
V
Q
F
H
L
Y
I
STSP
C
G
D
A
R
I
F
K
A
R
G
Q
-----------------
L
R
T
K
I
E
------
S
G
E
G
T
I
P
--
V
------
R
S
N
A
S
I
Q
T
W
D
G
--------
V
L
Q
G
E
R
L
L
T
M
S
C
S
D
K
I
A
R
W
N
V
V
G
-
I
Q
G
S
L
L
S
I
F
V
E
P
I
Y
F
S
S
I
I
L
GSLYH
G
D
H
L
S
R
-------------
A
M
Y
Q
R
I
SNIEDLPPL
Y
T
L
N
K
------
P
L
-
L
S
G
I
S
N
--
A
E
A
RQPGKAPN
F
S
----
V
N
W
T
V
GDS
A
I
E
V
I
N
------
A
T
T
G
K
DELGRA
S
R
L
C
K
H
A
L
Y
-----------------------
C
R
W
M
R
V
--------
H
G
K
V
P
S
H
L
L
R
S
-----------
K
I
T
------------
K
-
P
N
V
Y
H
E
--------
S
K
L
------
A
A
K
E
Y
Q
A
A
K
A
R
--------
L
F
T
-
A
F
--
I
K
A
GL
G
A
W
V
-
E
K
P
T
E
Q
D
Q
F
S
LT---------
7
PsiBlast_PDB
39.06
60%
-7
- C4 -
3G9K
-
CAPD_BACAN
L:
[190-214]
----------------------------------------------------------------------------
A
K
G
F
Y
E
G
G
V
A
R
A
I
S
K
T
A
K
I
-------
S
L
E
D
I
K
G
------
Y
K
V
E
V
-
R
K
P
V
---
K
G
N
---
Y
M
G
Y
D
--------------
V
Y
T
A
P
P
P
F
S
G
V
T
-------
L
L
Q
-----
M
L
K
-
L
A
E
------
K
K
E
V
Y
---
K
D
V
D
H
------
T
-----------
A
T
Y
----
M
S
K
M
--
E
E
I
S
R
I
A
Y
Q
D
------
R
K
K
N
L
G
----
M
--
D
P
N
K
M
V
----
S
D
K
Y
I
S
T
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.72
60%
-1
- C4 -
3GA9
-
?
L:
[190-214]
----------------------------------------------------------------------------
A
K
G
F
Y
E
G
G
V
A
R
A
I
S
K
T
A
K
I
-------
S
L
E
D
I
K
G
------
Y
K
V
E
V
-
R
K
P
V
---
K
G
N
---
Y
M
G
Y
D
--------------
V
Y
T
A
P
P
P
F
S
G
V
T
-------
L
L
Q
-----
M
L
K
-
L
A
E
------
K
K
E
V
Y
---
K
D
V
D
H
------
T
-----------
A
T
Y
----
M
S
K
M
--
E
E
I
S
R
I
A
Y
Q
D
------
R
K
K
N
L
G
----
M
--
D
P
N
K
M
V
----
S
D
K
Y
I
S
T
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
37.13
21%
-47
- C4 -
2LCK
-
UCP2_MOUSE
A:
[114-302]
-------------------------------------------------------------------------
A
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
A
Q
-------
P
T
D
V
V
K
V
------
R
F
Q
A
Q
-
A
R
A
G
---
G
------
G
R
R
Y
--------------
Q
S
T
V
E
A
Y
K
T
I
A
R
-------
E
E
G
-----
I
R
G
-
L
W
K
------
G
T
S
P
N
---
V
A
R
N
A
------
I
-----------
V
N
C
----
A
E
L
V
--
T
Y
D
L
I
K
D
T
L
L
------
K
A
N
L
M
----------
T
D
D
L
----
P
C
H
F
T
S
A
F
G
A
G
F
C
----
T
T
V
I
A
--
S
P
V
D
V
V
K
T
R
Y
M
------
N
-----
S
--
A
------
L
-----
G
Q
Y
H
S
--------
A
--
G
H
C
A
L
T
M
L
R
K
E
--------
G
-
P
R
A
F
Y
K
G
F
M
P
S
---
F
L
R
L
G
---------
S
W
N
-------------
V
V
M
F
V
T
---------
Y
E
Q
L
K
------
R
A
-
L
M
A
A
Y
Q
--
S
R
---------
E
A
----
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------