@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B3A2_HUMAN: (2015-12-07 )
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.-......340..----.....350.......360.......370.......380..-.....390.......400.......410.......420....-...430.......440.......-450.......460........470.........480.......490.......500.......510.......520...---.-...530.......540.......--550.......560.......570........580.......590.......600.......610.......620.......630.......640.......650.......660......----.670.......680---------...--....690.......700.......710.......720.......730.......740.......750.....-..760.......770.......780.......790.......800.......810--.........820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.-......990.......1000......1010......1020...-...1030......1040......1050......1060......1070......1080......1090......1100..---....1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPE
Q
E
E
D
E
L
H
R
T
L
G
V
E
R
F
E
E
I
L
Q
E
A
GSRGGEEPGRSY
G
E
E
D
F
E
Y
H
RQSSHHIHHPLSTHLPP
D
A
R
RRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDED
E
A
S
E
AEGARALTQPSPVSTPS
S
V
Q
F
F
L
QEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEA
E
A
V
A
V
ASGTAGGDDGGASGRPLPKAQPGHRSY
N
L
Q
E
R
R
RIGSMTG
A
E
Q
ALLPRVPT
D
E
I
E
A
Q
T
L
A
T
A
D
L
D
L
M
K
SHRFED
V
P
G
V
R
R
H
L
V
RKNAKGSTQSGREGREPGPTPRARPRAPHK
P
H
E
V
F
V
E
L
N
E
L
LLD-KNQEP
Q
W
R
E
T
A
----
R
W
I
K
F
E
E
D
V
E
E
E
T
E
RWGKPH
V
A
S
L
S
F
R
S
L
L
E
L
R
R
T
LAH
G
A
-
V
L
L
DLDQQTL
P
G
V
A
H
Q
V
V
E
Q
M
V
I
S
D
QIK
A
E
D
R
A
N
V
L
R
A
L
L
L
K-HSHPSDEKDFSFPRNISA
G
S
L
G
S
-
L
L
G
HHHGQGAES-DPHVTE
P
L
M--GGVPE
T
R
L
E
V
E
R
ERELPPPAPPAGITRSK
S
K
H
E
L
K
L
L
E
KIPENAE
A
T
V
V
L
V
G
C
V
E
---
F
-LSR
P
T
M
A
F
V
R
L
R
E
A
VE
L
D
A
VLEV--P
V
P
V
R
F
L
F
L
L
LGPSSANM
D
Y
H
-
E
I
G
R
S
I
S
T
L
MS
D
K
Q
F
H
E
A
A
Y
L
A
D
E
R
E
D
L
L
T
A
I
N
A
FL
D
C
S
V
VLPPSEV
Q
G
E
E
L
L
R
S
V
A
H
F
Q
R
Q
M
L
K
K
R
E
EQGRLLPTGAGLEPKS
A
Q
D
K
A
L
L
Q
M
V
E
AAG----AAEDD
P
L
RRTGR
P
F
---------
G
G
L
--
I
R
D
V
R
R
RY
P
H
Y
L
S
D
F
R
D
AL
D
P
Q
C
L
A
A
V
I
F
I
Y
F
A
A
L
S
P
A
I
T
F
G
G
LLG
E
K
T
Q
D
L
I
G
V
S
E
L
I
M
S
T
A
L
Q
G
V
V
F
C
L
L-GAQ
P
L
L
V
I
GFSG
P
L
L
V
F
E
E
A
F
F
S
F
C
SSN
H
L
E
Y
L
V
G
R
V
W
I
G
F
W
L
V
F
L
A
L
L
M
V
AL----E
G
S
F
L
V
R
F
V
S
R
F
T
Q
E
I
F
A
F
L
I
S
L
I
F
I
Y
E
T
F
Y
K
L
V
K
I
F
Q
EHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQ
P
N
T
A
L
L
S
L
V
L
M
A
G
T
F
F
I
A
F
F
L
R
K
FKNSRFF
P
G
R
I
R
R
V
I
G
DF
G
V
P
I
A
I
L
I
M
V
L
VDYSIED
T
Y
T
Q
KLSVPSGFSVTAPEKRG
W
V
INPL-GEKSP
F
P
V
W
M
M
V
A
S
L
L
P
A
I
L
V
F
I
L
I
F
M
ET
Q
I
T
T
L
I
I
S
K
K
E
R
M
L
-
Q
KGSGF
H
L
D
L
L
L
I
V
A
M
G
G
I
C
A
L
FG
L
P
W
L
A
A
A
T
V
R
S
V
TH
A
N
A
L
T
V
M
S
K
AVAPGD
K
P
K
I
Q
E
V
K
E
Q
R
V
T
G
L
L
V
A
L
L
V
G
L
S
I
V
---
I
G
D
L
L
R
Q
I
P
L
A
V
L
F
G
I
F
L
Y
M
G
VTSL
N
G
I
Q
F
Y
E
R
L
H
L
L
L
MPPKHHP
D
V
T
Y
V
K
K
V
R
T
L
R
M
H
L
F
T
A
L
Q
L
L
C
L
A
L
L
W
A
V
M
S
T
A
A
S
L
A
F
P
F
I
L
I
L
T
V
P
L
R
M
V
V
L
T
R
I
FTDREMKCLDANEAEPVFDEREGV
D
E
Y
NEMPMPV
2
PsiBlast_PDB
98.35
44%
-65
- C4 -
4KY9
-
B3AT_HUMAN
A:
[7-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
E
L
Q
E
L
V
M
D
E
K
N
Q
E
L
R
W
M
E
A
A
----
R
W
V
Q
L
E
E
N
L
G
E
N
G
A
-
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
--------------
A
G
E
L
E
A
-
L
G
G
V
K
P
A
V
L
T
R
---
P
--
S
Q
P
L
L
PQ
H
S
S
L
E
T
Q
L
F
C
E
--------------------------
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.82
42%
-61
- C4 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
D
E
K
N
Q
E
L
R
W
M
E
A
A
----
R
W
V
Q
L
E
E
N
L
G
E
N
G
-
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
--------------
A
G
E
L
E
A
-
L
G
G
V
K
P
A
V
L
T
R
S
G
D
P
--
S
Q
P
L
L
PQ
H
S
S
L
E
T
Q
L
F
C
E
Q
G
D
G
G
T
E
G
H
S
P
S
G
I
-----------
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
V
-
E
L
--
P
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
94.82
42%
-49
- C4 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
D
E
K
N
Q
E
L
R
W
M
E
A
A
----
R
W
V
Q
L
E
E
N
L
G
E
-
N
G
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
L
E
A
L
G
-
G
V
K
-
P
A
V
L
T
R
---
S
G
D
P
S
-
Q
P
L
L
-------------
P
Q
H
S
S
---
L
--
E
T
Q
--
L
F
C
E
Q
G
D
G
G
--
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
-
V
E
L
--
P
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
94.76
44%
-53
- C4 -
1HYN
-
B3AT_HUMAN
P:
[56-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
V
E
L
Q
E
L
V
M
D
E
K
N
Q
E
L
R
W
M
E
A
A
----
R
W
V
Q
L
E
E
N
L
G
E
N
-
G
A
W
G
R
P
H
L
S
H
L
T
F
W
S
L
L
E
L
R
R
V
F
T
K
G
T
-
V
L
L
D
L
Q
E
T
S
L
A
G
V
A
N
Q
L
L
D
R
F
I
F
E
D
Q
I
R
P
Q
D
R
E
E
L
L
R
A
L
L
L
K
-
H
S
H
A
G
E
L
E
A
L
G
G
V
K
P
A
V
L
T
R
S
G
D
-----------------
P
S
Q
P
L
L
--
P
Q
H
S
S
L
E
T
Q
L
F
C
E
Q
---------
G
D
G
G
T
E
G
H
S
P
S
G
I
L
E
K
I
P
P
D
S
E
A
T
L
V
L
V
G
R
A
D
---
F
-
L
E
Q
P
V
L
G
F
V
R
L
Q
E
A
A
E
L
E
A
-
V
E
L
--
P
V
P
I
R
F
L
F
V
L
L
G
P
E
A
P
H
I
D
Y
T
-
Q
L
G
R
A
A
A
T
L
M
S
E
R
V
F
R
I
D
A
Y
M
A
Q
S
R
G
E
L
L
H
S
L
E
G
F
L
D
C
S
L
V
L
P
P
T
D
A
P
S
E
Q
A
L
L
S
L
V
P
V
Q
R
E
L
L
R
R
R
Y
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
62.93
29%
-58
- C4 -
3URR
3
?
A:
[2-152]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
N
R
L
A
K
I
L
P
L
E
N
-
V
V
I
G
L
S
V
T
S
K
K
R
V
F
E
Q
A
G
L
I
F
E
N
Q
N
G
I
---
A
R
S
T
V
T
D
N
L
F
A
R
-
E
R
L
---------------
G
S
T
G
---
L
G
E
G
V
--------------------------------------------------------
A
I
P
H
---------
G
R
I
K
---
G
-
L
K
H
P
L
A
A
F
V
R
L
A
E
P
I
P
F
E
A
P
D
G
----
Q
P
V
S
L
L
I
F
L
L
V
P
E
Q
A
T
Q
A
H
L
-
E
I
L
S
E
I
A
Q
L
L
S
D
R
D
T
R
E
R
L
H
T
E
P
D
R
D
E
L
H
R
L
L
T
Q
W
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
60.77
23%
-54
- C4 -
1A6J
1
PTSN_ECOLI
A:
[8-157]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
S
S
V
L
N
R
E
C
-
T
R
S
R
V
H
C
Q
S
K
K
R
A
L
E
I
I
S
E
L
A
A
K
Q
L
S
L
P
---
P
Q
V
V
F
E
A
I
L
T
R
-
E
K
M
---------------
G
S
T
G
---
I
G
N
G
I
--------------------------------------------------------
A
I
P
H
---------
G
K
L
E
E--
D
-
T
L
R
A
V
G
V
F
V
Q
L
E
T
P
I
A
F
D
A
I
D
N
----
Q
P
V
D
L
L
F
A
L
L
V
P
A
D
Q
T
K
T
H
L
-
H
T
L
S
L
V
A
K
R
L
A
D
K
T
I
C
R
R
L
R
A
A
Q
S
D
E
E
L
Y
Q
I
I
T
D
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
59.90
17%
-54
* C4 *
3OXP
-
?
A:
[4-150]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
T
L
L
T
S
D
V
-
I
Q
V
V
S
Q
A
K
D
W
R
D
A
I
A
I
S
C
Q
P
L
I
D
N
G
A
V
E
----
A
R
Y
V
E
A
I
Y
R
S
H
E
A
I
---------------
G
P
Y
Y
V
--
V
G
P
G
I
--------------------------------------------------------
A
M
P
H
---------
A
R
P
E
D--
G
-
V
N
R
L
S
L
A
L
T
V
I
T
E
G
V
T
F
N
A
E
G
N
----
D
P
V
K
L
L
I
V
L
A
A
T
D
S
--
N
S
H
I
-
E
A
I
S
Q
L
A
Q
L
F
D
T
A
S
D
V
Q
A
L
L
N
A
K
T
P
Q
D
I
L
S
V
I
A
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
59.56
24%
-61
- C4 -
2A0J
-
?
A:
[4-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
I
L
P
L
S
H
-
I
V
L
D
M
E
V
G
S
K
K
R
L
F
E
E
A
G
L
L
L
E
R
E
S
S
L
S
---
H
A
D
V
F
E
C
L
F
A
R
-
E
K
L
---------------
G
S
T
G
---
L
G
Q
G
V
--------------------------------------------------------
A
I
P
H
---------
G
R
H
A
---
G
-
V
K
Q
A
T
G
A
F
I
R
T
R
E
P
V
G
F
D
A
P
D
G
----
K
P
V
S
L
I
F
I
L
L
V
P
E
N
A
T
G
E
H
L
-
E
V
L
S
K
L
A
G
K
F
S
Q
K
S
I
R
E
S
L
M
T
V
S
S
A
E
E
V
R
A
I
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
58.04
14%
-58
- C4 -
2OQ3
-
PTMA_ECOLI
A:
[2-146]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
D
Y
F
P
E
S
S
-
I
S
V
I
H
S
A
K
D
W
Q
E
A
I
D
F
S
M
V
S
L
L
D
K
N
Y
I
----
S
E
N
Y
I
Q
A
I
K
D
S
-
T
I
N
N
--------------
G
P
Y
Y
--
I
L
A
P
G
V
--------------------------------------------------------
A
M
P
H
---------
A
R
P
E
---
C
G
A
L
K
T
G
M
S
L
T
L
L
E
Q
G
V
Y
F
P
G
N
D
-----
E
P
I
K
L
L
I
G
L
S
A
A
D
A
--
D
S
H
I
-
G
A
I
Q
A
L
S
E
L
L
C
E
E
E
I
L
E
Q
L
L
T
A
S
S
E
K
Q
L
A
D
I
I
S
R
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
57.21
19%
-68
- C4 -
3BJV
-
?
A:
[3-149]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
Q
A
F
K
E
N
H
S
I
R
L
G
L
T
A
K
D
W
K
E
A
V
K
L
S
V
T
P
L
I
E
S
G
A
V
K
----
P
E
Y
Y
N
A
I
I
E
S
T
E
S
Y
---------------
G
P
Y
Y
--
I
L
M
P
G
M
--------------------------------------------------------
A
M
P
H
---------
A
R
P
E
A--
G
-
V
Q
R
D
A
F
S
L
V
T
L
T
E
P
V
T
F
T
D
G
------
K
E
V
Q
V
L
L
A
L
A
A
T
S
S
--
K
I
H
T
S
V
A
I
P
Q
I
I
A
L
F
E
L
D
H
S
I
E
R
L
V
N
C
K
T
P
E
E
V
L
A
M
V
E
E
S
K
S
S
P
Y
L
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
54.70
15%
-60
- C4 -
1A3A
-
PTM3C_ECOLI
A:
[4-147]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
K
L
G
A
E
N
-
I
F
L
G
R
K
A
A
T
K
E
E
A
I
R
F
A
G
E
Q
L
V
K
G
G
Y
V
E
----
P
E
Y
V
Q
A
M
L
D
R
-
E
K
L
---------------
T
P
T
Y
---
L
G
E
S
I
--------------------------------------------------------
A
V
P
H
---------
G
T
V
E
AKD
R
-
V
L
K
T
G
V
V
F
C
Q
Y
P
E
G
V
R
F
G
E
E
E
----
D
D
I
A
R
L
V
I
G
I
A
A
R
N
N
---
E
H
I
-
Q
V
I
T
S
L
T
N
A
L
D
D
E
S
V
I
E
R
L
A
H
T
T
S
V
D
E
V
L
E
L
L
A
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
53.81
12%
-132
- C4 -
3QE7
2
URAA_ECOLI
A:
[11-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
P
-
L
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
---
F
G
A
T
V
L
V
P
V
L
F
H
------------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
---
P
V
L
L
L
L
-
P
L
G
Y
E
V
A
---
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
----
L
L
P
------
A
E
-------------------------------------
G
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-
F
--------
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
--
I
I
---------
N
A
H
W
F
A
L
P
T
L
Y
T
P
-
R
F
E
-
W
---
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
----------
R
V
--------
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
-----------------------------------------------
27
HHSearch
52.04
13%
-48
- C4 -
3T43
-
?
A:
[3-140]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
D
I
I
K
A
L
A
S
P
L
I
N
D
G
M
V
----
V
S
D
F
A
D
H
V
I
T
R
-
E
Q
N
---------------
A
P
T
G
L
P
V
E
P
V
G
V
--------------------------------------------------------
A
I
P
H
---------
T
D
S
K
---
Y
-
V
R
Q
N
A
I
S
V
G
I
L
A
E
P
V
N
F
E
D
A
G
G
E
PD
P
V
P
V
R
V
V
F
M
L
A
L
G
N
W
--
F
D
I
T
-
N
V
L
W
W
I
M
D
V
I
Q
D
A
D
F
M
Q
Q
L
L
V
M
N
D
D
-
E
I
Y
Q
S
I
Y
T
R
I
S
E
A
A
G
M
A
G
I
H
F
R
R
H
Y
V
R
H
L
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
45.13
15%
11
- C4 -
2OQT
-
?
A:
[7-151]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
N
N
S
-
I
R
L
G
L
S
A
D
T
W
Q
E
A
V
R
L
A
V
Q
P
L
I
D
S
K
A
V
T
----
S
A
Y
Y
D
A
I
I
A
S
T
E
K
Y
---------------
G
P
Y
Y
V
--
L
M
P
G
M
--------------------------------------------------------
A
M
P
H
---------
A
E
A
-L--
G
-
V
N
R
N
A
F
A
L
I
T
L
T
K
P
V
T
F
S
D
--
G
----
K
E
V
S
V
L
L
T
L
A
A
T
D
P
--
S
I
H
T
T
V
A
I
P
Q
I
V
A
L
F
E
L
D
N
A
I
E
R
L
V
A
C
Q
S
P
K
E
V
L
E
M
V
E
E
S
K
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
43.32
23%
100
- C4 -
1V5Y
4
FRA1_ALIFS
A:
[98-209]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
S
K
A
V
A
D
-
K
R
I
T
E
E
Q
K
E
A
A
F
A
SF
K
F
V
E
L
N
C
D
E
N
G
E
H
K
A
W
T
K
P
Q
----
A
Y
L
A
L
G
N
A
L
H
T
L
A
R
-----
L
N
I
D
S
T
T
M
E
G
I
D
P
E
L
L
S
E
-
I
F
A
D
E
L
K
G
Y
E
---
C
H
V
A
L
A
I
G
-
Y
H
H
P
S
E
D
Y
N
A
S
L
P
K
S
R
K
A
F
E
D
V
I
-
T
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.57
23%
94
- C4 -
1V5Z
4
FRA1_ALIFS
A:
[98-209]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
S
K
A
V
A
D
-
K
R
I
T
E
E
Q
K
E
A
A
FASF
K
F
V
E
L
N
C
D
E
N
G
E
H
K
A
W
T
K
P
Q
----
A
Y
L
A
L
G
N
A
L
H
T
L
A
R
-----
L
N
I
D
S
T
T
M
E
G
I
D
P
E
L
L
S
E
-
I
F
A
D
E
L
K
G
Y
E
---
C
H
V
A
L
A
I
G
-
Y
H
H
P
S
E
D
Y
N
A
S
L
P
K
S
R
K
A
F
E
D
V
I
-
T
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.54
23%
99
- C4 -
1VFR
2
FRA1_ALIFS
A:
[99-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
S
K
A
V
A
D
-
K
R
I
T
E
E
Q
K
E
A
A
FASF
K
F
V
E
L
N
C
D
E
N
G
E
H
K
A
W
T
K
P
Q
----
A
Y
L
A
L
G
N
A
L
H
T
L
A
R
-----
L
N
I
D
S
T
T
M
E
G
I
D
P
E
L
L
S
E
-
I
F
A
D
E
L
K
G
Y
E
---
C
H
V
A
L
A
I
G
-
Y
H
H
P
S
E
D
Y
N
A
S
L
P
K
S
R
K
A
F
E
D
V
I
-
T
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
36.25
28%
126
- C3 -
4RHL
-
?
A:
[186-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
L
L
K
G
V
V
S
V
G
NRQV
S
S
E
D
R
K
V
R
K
L
H
K
M
F
Y
M
D
M
H
A
I
Y
S
K
G
L
FC
I
R
D
I
R
N
D
Y
P
V
F
I
S
I
D
A
D
V
L
D
P
------------
A
F
A
P
A
V
D
S
P
V
A
G
G
L
S
T
R
D
L
L
H
I
M
N
G
I
R
G
P
K
V
V
G
I
D
V
Y
G
Y
-
N
P
D
L
D
V
Y
R
K
D
N
V
G
L
T
A
I
A
L
S
K
I
I
K
E
G
I
L
K
A
Y
S
I
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
35.70
28%
392
- C1 -
1OOP
-
?
C:
[5-60]
-------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
P
G
S
N
Q
F
L
T
S
D
D
F
Q
-----------
S
P
S
A
M
P
Q
F
D
V
T
P
E
M
D
I
P
G
Q
V
N
N
L
M
E
I
A
E
V
D
S
V
V
P
V
N
N
T
E
G
K
V
M
S
I
E
A
Y
Q
I
P
V
Q
S
N
P
T
N
G
S
Q
V
F
G
F
P
L
T
P
G
A
N
S
V
L
N
R
T
L
L
G
E
I
L
N
Y
Y
A
H
W
S
G
S
I
K
L
T
F
M
F
C
G
S
A
M
A
T
G
K
F
L
L
A
Y
S
P
P
G
A
G
A
P
T
T
R
K
E
A
M
L
G
T
H
V
I
W
D
V
G
L
Q
S
S
C
V
L
C
I
P
W
I
S
Q
T
H
Y
R
Y
V
V
M
-
D
E
Y
T
A
G
G
Y
I
T
C
----
W
Y
Q
T
N
I
V
V
P
A
D
A
Q
S
D
C
K
I
L
C
F
V
S
A
C
N
D
F
S
V
R
M
L
K
D
T
P
F
I
K
-
Q
D
N
F
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
35.61
28%
128
- C3 -
4RHM
3
?
A:
[186-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
L
L
K
G
V
V
S
V
G
NRQV
S
S
E
D
R
K
V
R
K
L
H
K
M
F
Y
M
D
M
H
A
I
Y
S
K
G
L
FC
I
R
D
I
R
N
D
Y
P
V
F
I
S
I
D
A
D
V
L
D
P
------------
A
F
A
P
A
V
D
S
P
V
A
G
G
L
S
T
R
D
L
L
H
I
M
N
G
I
R
G
P
K
V
V
G
I
D
V
Y
G
Y
-
N
P
D
L
D
V
Y
R
K
D
N
V
G
L
T
A
I
A
L
S
K
I
I
K
E
G
I
L
K
A
Y
S
I
S
T
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------