@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CMC1_HUMAN: (2015-12-07 )
MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ
Atome Classification :
(20 SA)
-------------.........10....-....20.......-----.-----30--........40-----.......-----.50.---.......60......-------.-.70........80....-----------....90........100.......---110.......120....-..----...130....-...140......--.150.....------------.----------.160.......170.......180......---.190....--------...200..--.....210.......220.......230.......240......--.250------........260.......270.......280..-.....290...---....300.......310.-......320.......330.......340.......350......---.360.......370.......380.......390..-----------.....400.----......410.....-----..420----....--------....430-.-......440.......450...------....460----.------........470...--------..-..480.......490------.........500.----......510........520..---.....530.....-..540...--....550---...--...-...560.....-..570.......580...----....590.......600.......610.......620.......630.......640.......650.......660.......670......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------M
A
V
K
V
Q
TTKRG
D
P
H
E
-
L
R
N
I
F
L
Q
YASTEV-----D-----GE--RYM
T
P
E
D
F
V
Q
-----
R
Y
L
GLYN-----DPNS---
N
P
K
I
V
Q
L
L
A
G
VADQT-------K-
D
G
L
I
S
Y
Q
E
F
L
A
F
E
S
V
LC-----------APD
S
M
F
I
V
A
F
Q
L
FDKSGNG
E
V
T
F
E
---
N
V
K
E
I
F
G
Q
T
I
I
--
H
HHI-PF----NWDC
E
F
I
R
L
H-FGHNRKKHL
N
Y
T
--
E
F
T
Q
F
L
Q
E
L
------------
Q
----------
L
E
H
A
R
Q
A
FALKDKSKSGMISGL
D
F
S
D
I
M
V
T
---
I
R
S
H
ML
T
P
--------
F
V
E
E
N
L
V
S
--AAGGS
I
S
H
Q
V
S
F
S
Y
F
N
A
F
N
S
L
L
N
N
M
E
L
V
R
K
I
Y
S
T
L
AGTRK
D
V
E
V
--
T
K
E
-------
E
F
A
Q
S
A
I
RYGQVT
P
L
E
I
D
I
L
Y
Q
L
A
D
L
YNASG
R
L
-
T
L
A
D
I
E
R
I
A
P
L---AEGALPY
N
L
A
E
L
Q
R
QQSP-GLG
R
P
I
W
L
Q
I
A
E
S
A
Y
R
F
T
L
G
S
VAGAVGA
T
A
V
Y
P
I
D
L
V
K
T
R
M
QNQR---GS
G
S
V
V
G
E
L
M
YKN
S
F
D
C
F
K
K
V
L
R
YE
G
F
F
G
L
Y
R
G
L
I
P
-----------
Q
L
IGVAPE
K
----
A
I
K
L
T
V
N
D
F
V
R
D
K
F-----TRRD-----GSVP--------L
P
A
E
V
L
A-G-GCAGG
S
Q
V
I
F
TN
P
L
E
I
V
K
I
R
L
Q
------
V
A
G
EI------T------TGP
R
V
S
A
L
N
V
L
R
D
L
--------
G
I
-
F
G
L
YKGA
K
A
C
F
LR--------DIP
F
S
A
I
Y
F
P
V
Y
A
----
H
C
K
L
L
L
AD-ENGHVG
G
L
N
L
L
A
A
---
G
AMAGVP
A
A
SLV
T
-
P
A
D
V
I
K
T
R
--
L
Q
V
A
A-----RAG--Q
T
T
-
Y
S
G
V
I
D
C
F
R
K
I
-
L
R
EEGP
S
A
F
W
K
G
T
A
A
R
V
F----RSSPQFG
V
T
L
V
T
Y
E
L
L
Q
R
W
F
Y
I
DFGGLKPAGSEPTPKSRIADLPPANPDHIG
G
Y
R
L
A
T
A
T
FAGIENKFGLYLPKFKSP
S
V
A
V
VQP
K
A
AVAATQ
1
PsiBlast_PDB
89.13
100%
-121
- C3 -
4P5X
-
CMC1_HUMAN
A:
[18-298]
--------------------------
H
E
-
L
R
N
I
F
L
Q
Y
A
S
T
E
V
-----
D
-----
G
E
--
R
Y
M
T
P
E
D
F
V
Q
-----
R
Y
L
G
L
Y
N
-----
D
P
N
S
---
N
P
K
I
V
Q
L
L
A
G
V
A
D
Q
T
-------
K
-
D
G
L
I
S
Y
Q
E
F
L
A
F
E
S
V
L
C
-----------
A
P
D
S
M
F
I
V
A
F
Q
L
F
D
K
S
G
N
G
E
V
T
F
E
---
N
V
K
E
I
F
G
Q
T
I
----
H
H
I
-
P
F
----
N
W
D
C
E
F
I
R
L
H
-
F
G
H
N
R
K
K
H
L
N
Y
T
--
E
F
T
Q
F
L
Q
E
L
------------
Q
----------
L
E
H
A
R
Q
A
F
A
L
K
D
K
S
K
S
G
M
I
S
G
L
D
F
S
D
I
M
V
T
---
I
R
S
H
M
L
T
P
--------
F
V
E
E
N
L
V
S
--
A
A
------
Q
V
S
F
S
Y
F
N
A
F
N
S
L
L
N
N
M
E
L
V
R
K
I
Y
S
T
L
------
V
E
V
--
T
K
E
-------
E
F
A
Q
S
A
I
R
Y
G
Q
V
T
P
L
E
I
D
I
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
-
T
L
A
D
I
E
R
I
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
88.86
68%
-107
- C3 -
4P5W
-
CMC2_HUMAN
A:
[31-394]
--------------------
T
K
R
A
D
P
A
E
-
L
R
T
I
F
L
K
Y
A
S
I
E
K
-----
N
-----
G
E
--
F
F
M
S
P
N
D
F
V
T
-----
R
Y
L
N
I
F
S
-----
Q
P
N
-----
P
K
T
V
E
L
L
S
G
V
V
D
Q
T
-------
K
-
D
G
L
I
S
F
Q
E
F
V
A
F
E
S
V
L
C
-----------
A
P
D
A
L
F
M
V
A
F
Q
L
F
D
K
A
G
K
G
E
V
T
F
E
---
D
V
K
Q
V
F
G
Q
T
T
I
--
H
Q
H
I
-
P
F
----
N
W
D
S
E
F
V
Q
L
H
-
F
G
K
E
R
K
R
H
L
T
Y
A
--
E
F
T
Q
F
L
L
E
I
------------
Q
----------
L
E
H
A
K
Q
A
F
V
Q
R
D
N
A
R
T
G
R
V
T
A
I
D
F
R
D
I
M
V
T
---
I
R
P
H
V
L
T
P
--------
F
V
E
E
C
L
V
A
--
A
A
G
G
T
T
S
H
Q
V
S
F
S
Y
F
N
G
F
N
S
L
L
N
N
M
E
L
I
R
K
I
Y
S
T
L
A
G
T
R
K
D
V
E
V
--
T
K
E
-------
E
F
V
L
A
A
Q
K
F
G
Q
V
T
P
M
E
V
D
I
L
F
Q
L
A
D
L
Y
E
P
R
G
R
M
-
T
L
A
D
I
E
R
I
A
P
P
NPD
H
V
G
G
Y
K
L
A
V
A
T
F
A
G
I
E
N
K
F
G
L
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.31
100%
-118
- C3 -
4P60
-
CMC1_HUMAN
A:
[61-299]
-----------------------------------------------------------------------------------------------
V
Q
L
L
A
G
V
A
D
Q
T
-------
K
-
D
G
L
I
S
Y
Q
E
F
L
A
F
E
S
V
L
C
-----------
A
P
D
S
M
F
I
V
A
F
Q
L
F
D
K
S
G
N
G
E
V
T
F
E
---
N
V
K
E
I
F
G
Q
T
I
I
--
H
H
H
I
-
P
F
----
N
W
D
C
E
F
I
R
L
H
-
F
G
H
N
R
K
K
H
L
N
Y
T
--
E
F
T
Q
F
L
Q
E
L
------------
Q
----------
L
E
H
A
R
Q
A
F
A
L
K
D
K
S
K
S
G
M
I
S
G
L
D
F
S
D
I
M
V
T
---
I
R
S
H
M
L
T
P
--------
F
V
E
E
N
L
V
S
--
A
A
G
G
S
I
S
H
Q
V
S
F
S
Y
F
N
A
F
N
S
L
L
N
N
M
E
L
V
R
K
I
Y
S
T
L
A
G
T
R
K
D
V
E
V
--
T
K
E
-------
E
F
A
Q
S
A
I
R
Y
G
Q
V
T
P
L
E
I
D
I
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
-
T
L
A
D
I
E
R
I
A
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
51.80
14%
-48
- C2 -
4M59
2
?
A:
[6-714]
PD
A
Q
V
L
V
L
A
I
S
S
H
P
L
P
T
L
A
A
F
L
A
S
R
R
D
E
-
L
L
R
A
D
I
T
S
L
L
K
A
L
-----
E
-----
L
S
--
G
H
W
E
W
A
L
A
L
L
-----
R
W
A
G
K
E
G
-----
A
A
D
A
---
S
A
L
E
M
V
V
R
A
L
G
R
E
G
Q
-------
H
-
D
A
V
C
A
L
L
D
E
T
P
L
P
P
G
S
R
-----------
L
D
V
R
A
Y
T
T
V
L
H
A
L
S
R
A
G
R
Y
E
R
A
L
E
---
L
F
A
E
L
R
R
Q
G
V
A
--
P
T
L
V
-
T
Y
----
N
V
V
L
D
V
Y
G
--------
R
M
G
R
S
W
P
--
R
I
V
A
L
L
D
E
M
------------
R
A
A
G
V
E
P
D
---
G
F
T
A
S
T
V
I
A
A
C
S
R
D
G
L
V
D
E
A
V
A
F
F
E
D
L
K
A
-----
R
G
H
A
P
S
V
--------
V
T
Y
N
A
L
L
Q
--
V
F
G
K
A
G
N
Y
T
E
A
L
R
V
L
G
E
M
E
Q
--
N
G
C
Q
P
D
A
V
T
Y
N
E
L
A
G
T
E
E
A
A
R
C
--
L
D
T
M
A
SPN
A
F
T
Y
N
T
V
M
T
A
Y
G
N
V
G
K
--
V
D
E
A
L
A
L
F
D
Q
M
K
K
T
G
F
V
P
N
V
N
T
Y
N
L
V
L
G
M
---
L
G
K
K
S
R
F
T
V
M
L
E
M
L
G
E
M
S
-
R
S
G
C
T
-----
P
N
R
V
T
W
N
T
M
L
A
V
S
G
K
R
G
-----
M
E
D
Y
V
T
R
V
L
E
G
M
R
---
S
S
G
V
E
L
S
R
D
T
Y
N
T
L
I
A
A
Y
G
R
C
G
S
R
T
N
A
F
K
M
Y
N
E
M
T
S
A
G
F
T
P
C
I
T
T
Y
N
A
L
L
N
V
L
S
R
Q
GD
W
S
T
A
Q
S
I
V
S
K
M
R
T
K
G
F
-----
K
P
N
E
-----
Q
S
Y
S
--------
L
L
L
Q
C
Y
A
-
K
-
G
---------
G
N
V
A
G
I
A
A
I
E
N
E
------
V
Y
G
S
G
------
A
------
V
F
P
S
W
V
I
L
R
T
L
V
I
A
--------
N
F
K
C
R
R
L
D
G
M
E
T
A
F
Q
E
V
K
A
RG
Y
N
P
D
L
V
I
F
N
S
M
L
S
I
Y
A
K
N
GM
Y
S
K
A
T
E
V
F
-
D
S
I
K
R
S
G
L
S
P
D
L
I
---
T
Y
N
S
L
M
D
M
Y
A
K
C
S
-
E
S
W
E
A
E
K
I
--
L
N
Q
L
K
C
SQTM
K
P
D
--
V
V
S
-
Y
N
T
V
I
N
G
F
C
K
Q
G
L
V
K
E
A
Q
R
V
L
S
E
M
V
A
D
G
M
A
----
P
C
A
V
T
Y
H
T
L
V
G
G
Y
S
S
L
E
M
F
------------
S
E
A
R
E
V
I
G
Y
M
V
Q
H
G
L
K
P
M
E
L
T
Y
R
R
V
V
E
S
Y
C
R
A
F
E
E
A
R
G
F
L
S
E
---------
V
K
A
L
E
A
Y
I
E
D
A
9
PsiBlast_PDB
51.18
24%
-65
- C3 -
4NSD
-
MICU1_HUMAN
A:
[33-336]
-------------------------------
K
I
F
R
Y
F
A
T
L
K
V
I
S
E
PG
E
-----
A
E
--
V
F
M
T
P
E
D
F
V
R
S
I
T
PN-
H
L
G
L
D
Q
Y
I
I
--
K
---------------------S
I
F
Y
T
L
G
E
-
C
G
L
I
S
F
S
D
Y
I
F
L
T
T
V
L
S
-----------
T
P
Q
R
N
F
E
I
A
F
K
M
F
D
L
N
G
D
G
E
V
D
M
E
---
E
F
E
Q
V
--
Q
S
I
I
R
S--------------
C
S
A
L
T
T
Y
F
F
G
A
D
L
K
G
K
L
T
I
K
--
N
F
L
E
F
Q
R
K
L
------------
Q
----------
H
D
V
L
K
L
E
F
E
R
H
D
P
V
-
D
G
R
I
T
E
R
Q
F
G
G
M
L
L
A
Y
S
G
V
Q
S
K
K
L
T
A
---------
M
Q
R
Q
L
K
K
HF
K
E
G
K
G
L
T
F
Q
E
V
E
N
F
F
-
T
F
L
K
N
I
N
D
V
D
T
A
L
S
F
Y
H
-
M
A
G
A
S
L
D
-
K
V
--
T
M
Q
-------
Q
V
A
R
T
V
A
K
V
-
E
L
S
D
H
V
C
D
V
V
F
A
L
F
D
C
-
D
G
N
G
E
L
-
S
N
K
E
F
V
S
I
M
K
Q
---
R
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
50.60
28%
-37
- C4 -
1OKC
10
ADT1_BOVIN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
---
A
S
K
Q
I
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
-----
L
G
G
V
DRHKQ
F
W
R
Y
--------
F
A
G
N
L
A
S
-
G
-
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
------
A
D
V
G
K
GAAQRE
F
------
T
G
L
G
N
C
I
T
K
I
F
K
S
D
--------
G
L
-
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
----
T
A
K
G
M
L
P
D
-
P
K
-
N
V
H
I
I
V
S
W
M
I
---
A
Q
T
V
T
A
V
A
G
L
V
S
Y
-
P
F
D
T
V
R
R
R
--
M
M
M
Q
S
-----
G
R
K
GA
D
I
M
-
Y
T
G
T
V
D
C
W
R
K
I
-
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
----
R
G
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------
53
Fugue
50.55
20%
-56
- C3 -
4NSD
-
MICU1_HUMAN
A:
[15-349]
-------------
D
R
K
V
M
E
Y
E
N
R
I
R
A
Y
S
T
P
D
K
I
F
R
Y
F
A
T
L
K
V
-----
I
S
E
PG
E
A
E
--
V
F
M
T
P
E
D
F
V
R
-----
S
I
T
P
N
H
L
-----
G
L
D
Q
---
Y
I
I
K
S
I
F
----
Y
T
L
G
-------
E
-
C
G
L
I
S
F
S
D
Y
I
F
L
T
T
V
L
S
-----------
T
P
Q
R
N
F
E
I
A
F
K
M
F
D
L
N
G
D
G
E
V
D
M
E
---
E
F
E
Q
V
Q
S
I
I
R
S
--
C
S
A
L
-------------
T
T
Y
F
-
F
G
A
D
L
K
G
K
L
T
I
K
--
N
F
L
E
F
Q
R
K
L
------------
Q
----------
H
D
V
L
K
L
E
F
E
R
H
D
P
V
D
-
G
R
I
T
E
R
Q
F
G
G
M
L
L
A
---
Y
S
G
V
Q
S
K
K
--------
L
T
A
M
Q
R
Q
L
--
K
K
H
F
K
E
G
K
G
L
T
F
Q
E
V
E
N
F
F
T
F
L
K
N
I
N
D
V
D
T
A
L
S
F
Y
--
H
M
A
G
A
S
L
--
D
K
V
-------
T
M
Q
Q
V
A
R
T
V
A
K
-
V
E
L
S
D
H
V
C
D
V
V
F
A
L
F
D
C
D
G
N
G
-
E
L
S
N
K
E
F
V
S
I
M
---
K
Q
R
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
49.24
22%
-29
- C1 -
4CI7
10
?
A:
[4-470]
---------------
G
S
H
K
T
L
D
G
V
E
T
A
E
-
Y
S
E
S
Y
L
Q
Y
L
E
D
V
K
-----
N
-----
G
D
TA
K
Y
N
G
V
I
P
F
P
H
-----
E
M
E
G
T
T
L
-----
R
K
S
S
VAY
N
P
M
D
L
G
L
T
T
P
A
K
N
Q
G
-------
S
L
N
T
A
W
S
F
S
G
M
S
T
L
E
A
Y
L
K
-----------
L
K
G
Y
------------
G
T
Y
D
L
S
E
E
---
H
L
R
W
W
A
--------
T
G
G
-
K
Y
----
G
W
N
---------------------------------------------------------------
L
D
D
M
S
G
S
---
S
N
V
T
A
I
G
Y
L
T
A
---
W
A
G
P
K
L
E
K
--------
D
I
P
Y
N
L
K
S
--
E
A
Q
G
A
T
K
P
----
S
N
M
D
T
A
P
T
Q
F
N
V
T
D
V
V
R
------------
L
N
K
--
D
K
E
-------
T
V
K
N
A
I
M
Q
Y
G
S
V
T
S
G
Y
A
----
H
Y
S
T
Y
F
N
K
D
E
T
---------------------
A
Y
N
C
---
T
N
K
R
A
P
-------------------
L
N
H
A
V
A
I
V
G
W
D
D
N
Y
S
K
D
N
F
A
S
D
V
K
P
E
S
---
N
-----
G
A
W
L
V
K
S
S
W
G
E
F
N
S
---
M
K
G
F
F
W
I
S
---------------------
Y
E
D
K
----
T
L
L
T
D
T
D
N
Y
A
M
K
S
V
-----
S
K
P
D
-----
S
D
K
K
--------
M
Y
Q
L
E
Y
A
-
G
L
S
K
I
M
S
N
K
V
T
A
A
N
V
F
D
F
S
R
----------------------------
D
S
E
K
L
D
S
V
M
F
E
T
D
---------------
S
V
G
A
----------------
K
Y
E
V
Y
Y
A
P
V
V
---------------
N
G
-------------------------
V
-
P
Q
N
N
S
M
T
K
--
L
A
S
---------
G
--
T
V
S
-
Y
S
G
Y
I
N
V
P
T
-------
N
S
Y
S
L
P
K
G
K
G
A
I
V
V
V
I
D
N
T
A
N
P
N
R
E
K
S
T
L
A
Y
E
T
D
I
D
G
Y
Y
---------------------
L
Y
E
A
K
A
N
L
G
E
S
Y
I
L
Q
N
N
K
F
E
D
I
N
T
-----
Y
S
E
F
-
S
P
C
N
F
V
I
K
---
A
I
T
K
T
S
41
HHSearch
48.85
18%
-63
- C3 -
2ZND
5
PDCD6_HUMAN
A:
[6-169]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
F
L
W
N
V
F
Q
R
V
D
K
D
R
S
G
V
I
S
D
T
---
E
L
Q
Q
A
L
S
N
G
T
----
W
T
P
-
F
N
----
P
V
T
V
R
S
I
I
S
M
-
F
D
R
E
N
K
A
G
V
N
F
S
--
E
F
T
G
V
W
K
Y
------------------------
I
T
D
W
Q
N
V
F
R
T
Y
D
R
D
N
S
G
M
I
D
K
N
E
L
K
Q
A
L
S
G
---
F
G
-
Y
R
L
S
D
--------
Q
F
H
D
I
L
I
R
--
K
F
D
R
Q
G
R
G
Q
I
A
F
D
D
F
I
Q
G
C
I
V
L
---
Q
R
L
T
D
I
F
R
R
Y
-
D
T
D
Q
D
G
W
I
Q
V
S
Y
E
-------
Q
Y
L
S
M
V
F
S
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.89
28%
-37
- C4 -
4C9J
4
ADT3_YEAST
A:
[28-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
L
--
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
I
K
L
M
F
GF---
K
K
E
E
-----
G
Y
G
K
--------
W
F
A
G
N
L
A
S
G
-
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
------
A
D
A
K
S
-----------------
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
-
A
G
L
Y
R
G
F
M
P
S
V
V
G
--------
I
V
V
Y
R
G
L
Y
F
G
M
F
D
----
S
L
K
-------------------F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
-
P
L
D
T
V
R
R
R
--
M
M
M
T
S
-------
G
--
Q
A
V
K
Y
N
G
A
I
D
C
L
K
K
I
-
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
----
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
--------------------------------------------------------------------
7
PsiBlast_PDB
45.00
28%
-40
- C4 -
4C9H
5
ADT2_YEAST
A:
[27-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
K
Q
G
T
L
--
D
R
K
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
N
T
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
I
K
A
M
F
G
F
---
K
K
E
E
-----
G
Y
A
K
--------
W
F
A
G
N
L
A
S
G
-
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
------
A
D
S
-------------------
A
R
Q
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
-
A
G
L
Y
R
G
F
L
P
S
V
V
G
--------
I
V
V
Y
R
G
L
Y
F
G
M
Y
D
----
S
L
K
-------------
L
A
S
F
L
L
---
G
W
V
V
T
T
G
A
S
T
C
S
Y
-
P
L
D
T
V
R
R
R
--
M
M
M
T
S
-------
G
--
Q
A
V
K
Y
D
G
A
F
D
C
L
R
K
I
-
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
----
R
G
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
-------------------------------------------------------------------
16
PsiBlast_PDB
44.24
26%
-63
- C3 -
3DTP
-
MYL6_CHICK
C:
[11-149]
----------------------------------------------------------------------------------------------------------------------------------------------------
F
K
E
A
F
Q
L
F
D
R
T
G
D
G
K
I
L
Y
S
QCG
D
V
M
R
A
L
G
Q
N
---------
P
T
----
N
--
A
E
V
M
K
V
--
L
G
N
P
K
S
D
E
M
N
L
K
TL
K
F
E
Q
F
L
P
M
M
------------
Q
TIAKNKDQGC
F
E
D
Y
V
E
G
L
R
V
F
D
K
E
G
N
G
T
V
M
G
A
E
I
R
H
V
L
V
T
---
L
G
E
K
M
T
E
E
--------
E
V
E
Q
-
L
V
A
--
G
------
H
E
D
S
-------
N
G
C
I
N
Y
E
E
L
V
R
M
V
L
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
44.11
27%
-36
* C4 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
---
A
S
K
Q
I
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
GGVD
R
H
K
Q
-----
F
W
R
Y
--------
F
A
G
N
L
A
S
-
G
-
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
------
A
D
V
G
K
------
G
AAQREF
T
G
L
G
N
C
I
T
K
I
F
K
S
D
--------
G
L
-
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
----
T
A
K
G
M
L
-
P
-
D
P
K
N
V
H
I
I
V
S
W
M
I
---
A
Q
T
V
T
A
V
A
G
L
V
S
Y
-
P
F
D
T
V
R
R
R
--
M
M
M
Q
S
GR---
K
G
A
--
D
I
M
-
Y
T
G
T
V
D
C
W
R
K
I
-
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
----
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
------------------------------------------------------------------------------
6
PsiBlast_PDB
43.84
28%
-36
- C4 -
4C9Q
5
ADT3_YEAST
A:
[28-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
L
--
D
K
K
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
N
T
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
I
K
L
M
F
GF---
K
K
E
------
G
Y
G
K
--------
W
F
A
G
N
L
A
S
G
-
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
------
A
D
A
K
S
-----------------
A
R
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
-
A
G
L
Y
R
G
F
M
P
S
V
V
G
--------
I
V
V
Y
R
G
L
Y
F
G
M
F
D
----
S
L
K
P
L
-------------
F
L
A
S
F
L
L
G
W
V
V
T
T
G
A
S
T
C
S
Y
-
P
L
D
T
V
R
R
R
--
M
M
M
T
S
-------
G
--
Q
A
V
K
Y
N
G
A
I
D
C
L
K
K
I
-
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
----
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
----------------------------------------------------------------------
13
PsiBlast_PDB
43.46
26%
-66
- C3 -
1BR1
-
MYL6_CHICK
B:
[11-149]
----------------------------------------------------------------------------------------------------------------------------------------------------
F
K
E
A
F
Q
L
F
D
R
T
G
D
G
K
I
L
Y
S
Q
C
G
D
V
M
R
A
L
G
Q
N
---------
P
T
----
N
--
A
E
V
M
K
V
--
L
G
N
P
K
S
D
E
M
N
L
K
T
L
K
F
E
Q
F
L
P
M
M
------------
Q
T
I
A
K
NK
D
Q
G
C
F
E
D
Y
V
E
G
L
R
V
F
D
K
E
G
N
G
T
V
M
G
A
E
I
R
H
V
L
V
T
---
L
G
E
K
M
T
E
E
--------
E
V
E
Q
-
L
V
A
--
G
------
H
E
D
S
-------
N
G
C
I
N
Y
E
E
L
V
R
M
V
L
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
43.05
15%
-40
- C3 -
1IJ5
-
LAV1_PHYPO
A:
[149-349]
------------------------
S
E
E
D
-
T
N
I
L
R
Q
L
F
L
S
S
A
V
-----
S
-----
G
S
--
G
K
F
S
F
Q
D
L
K
Q
-----
V
L
A
K
Y
A
-------
D
T
I
---
P
E
G
P
L
K
K
L
F
V
M
V
E
N
D
-------
T
-
K
G
R
M
S
Y
I
T
L
V
A
V
A
N
D
---------------
L
A
A
L
V
A
D
F
R
K
I
D
T
N
S
N
G
T
L
S
R
K
---
E
F
R
E
H
F
V
R
L
G
-----
F
D
-
K
-----
K
S
V
Q
D
A
L
F
R
Y
-
A
D
E
D
E
S
D
D
V
G
F
S
--
E
Y
V
H
L
G
L
C
------------------------
L
L
V
L
R
I
L
Y
A
F
A
D
F
D
K
S
G
Q
L
S
K
E
E
V
Q
K
V
L
E
D
---
A
H
I
P
E
S
A
R
--------
K
K
F
E
H
Q
F
S
--
V
V
D
V
D
D
S
K
S
L
S
Y
Q
E
F
V
M
L
V
L
L
M
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.01
29%
-39
- C4 -
2C3E
4
ADT1_BOVIN
A:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
---
A
S
K
Q
I
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
-----
L
--------
G
G
V
D
RHKQ
F
W
R
Y
F
A
G
N
L
A
S
-
G
-
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
DVGKG
A
A
Q
R
E
------
F
------
T
G
L
G
N
C
I
T
K
I
F
K
S
D
--------
G
L
-
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
----
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
---
T
V
T
A
---
V
A
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
R
-----
K
G
A
--
D
I
M
-
Y
T
G
T
V
D
C
W
R
K
I
-
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
----
R
G
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------
17
PsiBlast_PDB
42.97
26%
-67
- C3 -
3J04
-
MYL6_CHICK
C:
[11-149]
----------------------------------------------------------------------------------------------------------------------------------------------------
F
K
E
A
F
Q
L
F
D
R
T
G
D
G
K
I
L
Y
S
Q
C
G
D
V
M
R
A
L
G
Q
N
---------
P
T
----
N
--
A
E
V
M
K
V
--
L
G
N
P
K
S
D
E
M
N
L
K
T
L
K
F
E
Q
F
L
P
M
M
------------
Q
T
I
A
K
NK
D
Q
G
C
F
E
D
Y
V
E
G
L
R
V
F
D
K
E
G
N
G
T
V
M
G
A
E
I
R
H
V
L
V
T
---
L
G
E
K
M
T
E
E
--------
E
V
E
Q
-
L
V
A
--
G
------
H
E
D
S
-------
N
G
C
I
N
Y
E
E
L
V
R
M
V
L
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.83
29%
-39
- C4 -
1OKC
10
ADT1_BOVIN
A:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
---
A
S
K
Q
I
S
A
E
K
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
-----------
N
V
I
R
Y
F
P
T
Q
----
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
-----
L
--------
G
G
V
D
RHKQ
F
W
R
Y
F
A
G
N
L
A
S
-
G
-
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
DVGKG
A
A
Q
R
E
------
F
------
T
G
L
G
N
C
I
T
K
I
F
K
S
D
--------
G
L
-
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
--------
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
----
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
---
T
V
T
A
---
V
A
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
R
-----
K
G
A
--
D
I
M
-
Y
T
G
T
V
D
C
W
R
K
I
-
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
----
R
G
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------
36
HHSearch
42.60
14%
-55
- C3 -
2F33
-
CALB1_RAT
A:
[9-257]
---------------------
S
L
I
T
A
S
Q
-
F
F
E
I
W
L
H
F
D
---
A
-----
D
-----
G
S
--
G
Y
L
E
G
K
E
L
Q
N
-----
L
I
Q
E
L
L
Q
A
R
K
K
A
G
L
E
L
---
S
-
P
E
M
K
T
F
V
D
Q
Y
G
Q
R
-------
D
-
D
G
K
I
G
I
V
E
L
A
H
V
L
P
T
E
E
NFLLLFRCQQL
K
S
C
E
E
F
M
K
T
W
R
K
Y
D
T
D
H
S
G
F
I
E
T
E
---
E
L
K
N
F
L
K
D
L
L
E
--
K
A
N
K
T
V
D
DTK
L
A
E
Y
T
D
L
M
L
K
L
-
F
D
S
N
N
D
G
K
L
E
L
T
--
E
M
A
R
L
L
P
V
Q
ENF
L
L
K
F
Q
G
I
KM
C
----------
G
K
E
F
N
K
A
F
E
L
Y
D
Q
D
G
N
G
Y
I
D
E
N
E
L
D
A
L
L
K
D
---
L
C
E
-
K
N
K
Q
ELDINN
I
S
T
Y
K
K
N
I
M
A
--
L
S
D
---
G
G
K
L
Y
R
T
D
L
A
L
I
L
S
A
G
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------