@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CTR1_HUMAN: (2015-12-07 )
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK
Atome Classification :
(20 SA)
-------------------.........10........20........30...----.....40....-....50...-.....60---------.....--...70........80........90........-----100.....-..-110--------.......-----..---120--..-.......130......---.140--.......150.......160...----------------....170----.........180.......190-------------.......------..200..---....----.210-.-......220----.......230..-------.....240.......250..---.....-260....---...---270.......280....---------------...-----290.......300-----....--...----------------------------..310-.....---------------.-..------.320.......330--.........340.--------------..--------....350...----.--.-------..360.......370.......380.------......390...---....400-------.-------.---.....410..----..---.---------..420.......430.......440.......450-----------------.........460----........470.-----....--..480.......---------490.-----......500-..---......510.......520...-----------....530......------------.540---.....--..550-........560.....-------..570.--...------...580....---...590...----------------....600------.--....--------.-------------------..610.......620.......-------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------MG
C
K
V
L
L
N
I
G
Q
Q
M
L
R
R
K
V
VDCS
R
E
E
T
R
L
S
R
C
L
N
T
----
F
D
L
V
A
L
GVGST-LG
A
G
V
Y
V
L
A
-
G
A
V
AREN---------AG
P
A
I
--
V
I
S
F
L
I
A
A
L
A
S
V
L
A
G
L
C
Y
G
E
FGARVPKTG
S
A
Y
L
-----
Y
S
Y
V
T
V
G
E
-
L
W
-
A
----------
F
I
T
G
W
N
L
-----
I
L
---
S
----
Y
I
-IG
T
S
S
V
A
R
A
W
S
A
T
F
D
E
---
L
IGR--P
I
G
E
FS
R
T
H
M
T
LNAPGVLAENP
D
----------------
I
F
A
V
I
------
I
I
L
I
L
T
G
L
L
TLGV
K
E
S
A
M
V
N
---------------
K
I
F
T
C
I
N
------
V
L
V
L
G
F
I
---
M
V
S
G
----
F
VKG-S-VKN
W
Q
L
T
E
E
----DFGNTSG
R
L
C
LN-------NDTKEGKPGVGGFMPF
G
F
S
G
---
V
L
S
G
A
-
A
T
C
F
Y
A
F
---VG
F
---
D
C
IATT
G
E
EVKNPQKAI---------------
P
V
G
-----
I
V
A
S
L
L
I
C
F
I
A
-------
Y
F
G
V
--
S
A
A
----------------------------
L
T
L
---
M
M
P
Y
F
---------------
C
-LD------NNSP
L
P
D
A
F
K
HV----GWEG
A
K
Y
A
V
A
V
G
S
--------------
L
C
--------
A
L
S
A
S
L
L
G
SM----F--P-------M
P
R
V
I
Y
A
MAED
G
L
L
F
K
F
L
ANVNDRTK------T
P
I
I
A
T
L
AS
G
A
V
---
A
A
V
M
A
F
L
-------
F
-------
D
---
L
K
D
L
V
D
L
M
S
I
----
G
T
---
L
---------
L
A
Y
S
L
V
A
A
C
V
L
V
LRYQPEQP
N
L
V
Y
Q
MASTSDEL-------------------DPAD
Q
N
ELAST-----NDSQLGFLP
E
A
E
-----
M
F
S
L
--
K
T
ILSPKNMEPS---------KI
S
G
-----
L
I
V
N
I
S
T
S
--
L
I
---
A
V
L
I
I
T
F
C
I
V
T
V
L
G
R
E
A
LTK
G
A
-----------
L
W
A
V
F
L
L
A
G
S
A
L
L
------------
C
A
V
V
---
T
G
V
IW--RQPE--SK
T
K
L
S
F
KVP
F
L
P
V
L
P
-------
I
L
S
I
F
V
--
N
V
Y
------
L
M
M
QLDQG
T
W
---
V
R
F
A
V
W
M
L
I
----------------
G
F
I
I
Y
F
-------G--YGLW--------H-------------------SEEASLDADQARTPDGNLDQCK-------------------------------------------------------------
30
Fugue
84.91
20%
-123
- C3 -
3GIA
7
Y609_METJA
A:
[3-435]
---------------------------------------------
L
K
N
K
K
L
S
L
----
W
E
A
V
S
M
A
V
G
V
M
-
I
G
A
S
I
F
S
I
F
-
G
V
G
A
K
I
----------
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
-----
F
I
H
K
A
I
G
D
N
I
I
-
T
----------
G
A
L
S
I
L
L
-----
W
M
---
S
----
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
---
L
I
N
A
--
P
I
N
---------------
T
F
N
I
A
----------------
I
T
E
I
G
------
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
---------------
F
F
I
V
L
V
K
------
L
L
I
L
G
L
F
---
I
F
A
G
----
L
I
T
I
-
H
-
P
S
Y
V
I
P
D
-------------------------------------
L
A
P
S
A
V
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
---
M
G
F
---
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
---------------
P
R
A
-----
I
F
I
S
I
L
I
V
M
F
V
-------
Y
V
G
V
--
A
I
S
----------------------------
A
I
G
---
N
L
P
I
D
---------------
E
-
L
I
K
A
----
S
E
N
A
L
A
V
A
A
K
P
F
----
L
G
N
L
G
F
L
L
I
S
I
G
A
--------------
L
F
--------
S
I
S
S
A
M
N
A
T
I
----
Y
--
G
-------
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
------
T
E
G
L
Y
I
T
--
S
A
L
---
G
V
L
F
A
L
L
-------
F
-------
N
---
M
E
G
V
A
S
I
T
S
A
----
V
F
---
M
---------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
V
I
F
S
F
I
V
-------
V
L
G
V
F
L
--
L
L
L
------
Y
Y
Q
W
I
T
N
R
F
V
---
F
Y
G
I
I
A
T
F
I
----------------
G
V
L
I
F
E
-------
I
--
I
Y
R
K
--------
V
-------------------
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------
22
HHSearch
83.59
20%
-125
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-379]
-----------------------------------------------
A
H
K
V
G
L
----
I
P
V
T
L
M
V
S
G
A
I
-
M
G
S
G
V
F
L
L
P
-
A
N
L
A
S
-----------
T
G
G
I
A
--
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
-----
Y
A
R
R
C
F
G
P
-
F
L
-
G
----------
Y
Q
T
N
V
L
Y
-----
W
L
---
A
----
C
W
-
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
---
F
F
P
I
--
L
K
D
P
---------------
W
V
L
T
----------------
I
T
C
V
V
------
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
---------------
A
V
A
T
V
L
A
------
L
I
P
I
V
G
I
---
A
V
F
G
----
W
F
W
F
-
R
-
G
E
T
Y
M
A
---------------------------------------------
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-----
S
A
S
P
F
G
D
A
A
R
M
A
----
L
G
D
T
A
G
A
I
V
S
F
C
A
--------------
A
A
--------
G
C
L
G
S
L
G
G
W
T
----
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
------
T
P
V
A
G
L
I
I
V
G
I
L
---
M
T
I
F
Q
L
S
SISPNAT
K
-------
E
---
F
G
L
V
S
S
V
S
V
I
----
F
T
---
L
---------
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
-------------------
L
Y
C
I
W
A
V
V
G
S
G
-----
A
K
E
V
M
W
S
F
V
T
L
M
-----
V
I
T
A
--
M
Y
A
L
N
Y
N
R
L
H
K
N
---------
P
Y
P
L
-----
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
80.01
22%
-117
- C3 -
3GIA
6
Y609_METJA
A:
[3-369]
---------------------------------------------
L
K
N
K
K
L
S
L
----
W
E
A
V
S
M
A
V
G
V
M
-
I
G
A
S
I
F
S
I
F
-
G
V
G
A
K
I
----------
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
-----
F
I
H
K
A
I
G
D
-
N
I
I
T
----------
G
A
L
S
I
L
L
-----
W
M
---
S
----
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
---
L
I
N
A
--
P
I
N
------------
T
---
F
N
I
A
----------------
I
T
E
I
G
------
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
---------------
F
F
I
V
L
V
K
------
L
L
I
L
G
L
F
---
I
F
A
G
----
L
I
T
I
-
H
-
P
S
Y
V
I
P
-------------------------------------
D
L
A
P
S
A
V
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
---
M
G
F
---
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
---------------
P
R
A
-----
I
F
I
S
I
L
I
V
M
F
V
-------
Y
V
G
V
--
A
I
S
----------------------------
A
I
G
---
N
L
P
I
D
---------------
E
-
L
I
K
A
----
S
E
N
A
L
A
V
A
A
K
P
F
----
L
G
N
L
G
F
L
L
I
S
I
G
A
--------------
L
F
--------
S
I
S
S
A
M
N
A
T
I
----
Y
--
G
-------
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
------
S
T
-
E
G
L
Y
I
T
S
A
L
---
G
V
L
F
A
L
L
-------
F
-------
N
---
M
E
G
V
A
S
I
T
S
A
----
V
F
---
M
---------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
-------------------
V
F
L
L
L
L
Y
Y
Q
W
I
-----
T
N
R
F
V
F
Y
G
I
I
A
T
-----
F
I
G
V
--
L
I
F
E
I
I
Y
R
K
V
T
K
---------
R
T
F
S
-----
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
79.41
16%
-108
- C2 -
4WZR
1
K0020_HUMAN
A:
[9-524]
------------------N
Y
D
I
V
V
R
A
K
Q
M
W
E
I
L
R
R
K
D
C
D
K
E
K
R
V
K
L
M
S
D
L
Q
K
L
I
QGK
I
K
T
I
A
F
A
H
D
S
T
-
R
V
I
Q
C
Y
I
Q
Y
-
G
N
E
E
Q
R
K
---------
Q
A
F
E
E
--
L
R
D
D
L
V
E
L
S
K
A
K
Y
S
R
N
I
V
K
K
F
L
M
Y
G
S
K
P
Q
I
A
E
I
-----
I
R
S
F
K
-
G
H
-
V
R
-
K
----------
M
L
R
H
A
E
A
S
A
---
I
V
---
E
----
Y
A
-
Y
N
D
K
A
I
L
E
Q
R
N
M
L
T
E
E
---
L
Y
G
N
--
T
F
Q
L
Y
K
S
A
D
H
P
-
T
L
D
K
V
L
E
L
Q
P
E
----------------
K
L
E
L
I
------
M
D
E
M
K
Q
I
L
T
P
M
A
Q
K
E
A
V
I
K
H
---------------
S
L
V
H
K
V
F
------
L
D
F
F
T
Y
A
P
P
K
L
R
S
E
----
M
I
E
A
I
R
-
E
A
V
V
Y
L
A
H
T
----
H
D
G
A
R
V
A
M
H
C
L
W
-------
H
G
T
P
K
D
R
K
V
I
V
K
T
M
K
T
Y
V
E
K
---
V
A
N
G
Q
-
Y
S
H
L
V
L
L
---
A
A
F
---
D
C
I
----
D
D
T
K
L
V
K
Q
I
I
---------------
I
S
E
-----
I
I
S
S
L
P
S
I
V
N
D
-------
K
Y
G
R
--
K
V
L
----------------------------
L
Y
L
---
L
-------------------------------
S
P
R
D
P
A
H
T
---------------------------------------------------------------------
V
R
E
I
I
E
V
L
Q
K
G
D
G
N
A
H
S
K
K
D
T
E
V
R
R
------
R
E
L
L
E
S
I
S
P
A
L
L
---
S
Y
L
Q
E
-----------------
H
---
A
Q
E
V
V
L
D
K
S
A
----
C
V
---
L
---------
V
S
D
I
L
G
S
A
T
------
G
D
V
Q
P
T
M
N
A
I
A
S
L
A
A
T
G
L
-------------------
H
P
G
G
K
D
----------
G
E
L
H
I
A
E
H
P
A
G
H
-----
L
V
L
K
--
W
L
I
E
Q
D
K
K
M
K
E
N
---------
G
R
E
G
---------------------------
C
F
A
K
T
L
V
E
H
V
G
M
K
N
L
-----------
K
S
W
A
S
V
N
R
G
A
I
I
L
------------
S
S
L
L
---
Q
S
C
-------
D
--
L
E
V
A
N
K
V
K
A
A
L
K
S
L
I
P
-------
T
L
E
S
K
G
--
I
E
I
------
L
L
E
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.57
21%
-108
- C3 -
3GI9
-
Y609_METJA
C:
[5-358]
-----------------------------------------------
N
K
K
L
S
L
----
W
E
A
V
S
M
A
V
G
V
M
-
I
G
A
S
I
F
S
I
F
-
G
-
V
G
A
K
I
---------
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
-----
F
I
H
K
A
I
G
D
----
N
----------
I
I
T
G
A
L
S
-----
I
L
L
W
M
S
----
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
---
L
I
-
A
--
P
I
N
T
F
---------------
N
I
A
----------------
I
T
E
I
G
------
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
---------------
F
F
I
V
L
V
K
------
L
L
I
L
G
L
F
---
I
F
A
G
----
L
I
---------------------------------------
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
---
M
G
F
---
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
---------------
P
R
A
-----
I
F
I
S
I
L
I
V
M
F
V
-------
Y
V
G
V
A
I
S
A
I
----------------------------
G
N
L
---
P
I
D
E
L
---------------
I
-
K
A
------
S
E
N
A
L
A
V
A
A
K
P
F
----
L
G
N
L
G
F
L
L
I
S
I
G
A
--------------
L
F
--------
S
I
S
S
A
M
N
A
T
I
----
Y
--
G
-------
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
------
T
E
--
G
L
Y
I
T
S
A
L
---
G
V
L
F
A
L
L
-------
F
-------
N
---
M
E
G
V
A
S
I
T
S
A
----
V
F
---
M
---------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
-------------------
V
F
L
L
L
L
Y
Y
Q
W
I
-----
T
N
R
F
V
F
Y
G
I
I
A
T
-----
F
I
G
V
--
L
I
F
E
I
I
Y
R
K
V
T
K
---------
R
T
F
S
-----
N
N
M
Y
V
K
S
L
--
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.49
21%
-105
- C3 -
3GIA
6
Y609_METJA
A:
[5-358]
-----------------------------------------------
N
K
K
L
S
L
----
W
E
A
V
S
M
A
V
G
V
M
-
I
G
A
S
I
F
S
I
F
-
G
-
V
G
A
K
I
---------
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
-----
F
I
H
K
A
I
G
D
----
N
----------
I
I
T
G
A
L
S
-----
I
L
L
W
M
S
----
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
---
L
I
N
A
--
P
I
N
T
F
---------------
N
I
A
----------------
I
T
E
I
G
------
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
---------------
F
F
I
V
L
V
K
------
L
L
I
L
G
L
F
---
I
F
A
G
----
L
I
---------------------------------------
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
---
M
G
F
---
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
---------------
P
R
A
-----
I
F
I
S
I
L
I
V
M
F
V
-------
Y
V
G
V
A
I
S
A
I
----------------------------
G
N
L
---
P
I
D
E
L
---------------
I
-
K
A
------
S
E
N
A
L
A
V
A
A
K
P
F
----
L
G
N
L
G
F
L
L
I
S
I
G
A
--------------
L
F
--------
S
I
S
S
A
M
N
A
T
I
----
Y
--
G
-------
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
------
T
E
--
G
L
Y
I
T
S
A
L
---
G
V
L
F
A
L
L
-------
F
-------
N
---
M
E
G
V
A
S
I
T
S
A
----
V
F
---
M
---------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
-------------------
V
F
L
L
L
L
Y
Y
Q
W
I
-----
T
N
R
F
V
F
Y
G
I
I
A
T
-----
F
I
G
V
--
L
I
F
E
I
I
Y
R
K
V
T
K
---------
R
T
F
S
-----
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.82
21%
-108
- C3 -
3GI8
-
Y609_METJA
C:
[5-358]
-----------------------------------------------
N
K
K
L
S
L
----
W
E
A
V
S
M
A
V
G
V
M
-
I
G
A
S
I
F
S
I
F
-
G
-
V
G
A
K
I
---------
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
-----
F
I
H
K
A
I
G
D
----
N
----------
I
I
T
G
A
L
S
-----
I
L
LWM
S
----
Y
V
-
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
---
L
I
N
A
--
P
I
N
T
F
---------------
N
I
A
----------------
I
T
E
I
G
------
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
---------------
F
F
I
V
L
V
A
------
L
L
I
L
G
L
F
---
I
F
A
G
----
L
I
---------------------------------------
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
---
M
I
F
A
S
-
A
I
F
F
L
S
Y
---
M
G
F
---
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
---------------
P
R
A
-----
I
F
I
S
I
L
I
V
M
F
V
-------
Y
V
G
V
AI
S
A
I
----------------------------
G
N
L
---
P
I
D
E
L
---------------
I
-
K
A
------
S
E
N
A
L
A
V
A
A
K
P
F
----
L
G
N
L
G
F
L
L
I
S
I
G
A
--------------
L
F
--------
S
I
S
S
A
M
N
A
T
I
----
Y
--
G
-------
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
------
T
E
--
G
L
Y
I
T
S
A
L
---
G
V
L
F
A
L
L
-------
F
-------
N
---
M
E
G
V
A
S
I
T
S
A
----
V
F
---
M
---------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
-------------------
V
F
L
L
L
L
Y
Y
Q
W
I
-----
T
N
R
F
V
F
Y
G
I
I
A
T
-----
F
I
G
V
--
L
I
F
E
I
I
Y
R
K
V
T
K
---------
R
T
F
S
-----
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
76.33
16%
-95
- C2 -
4TUU
-
PK3CA_HUMAN
A:
[5-944]
N
R
E
E
K
I
L
N
R
E
I
G
F
A
I
GMP
V
C
E
F
D
M
V
K
D
P
E
V
Q
D
F
R
R
N
I
L
N
V
C
K
E
A
V
D
L
R
D
L
N
S
P
----
H
S
R
A
M
Y
V
Y
P
P
N
-
V
E
S
S
P
E
L
P
K
-
H
I
Y
N
K
L
D
---------
K
G
Q
I
I
--
V
V
I
W
V
I
V
S
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
P
E
Q
V
I
A
E
A
-----
I
R
K
K
T
R
S
M
-
L
Y
-
Q
------------
G
K
Y
I
L
-----
K
V
---
C
GCDE
Y
F
-
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
---
M
L
G
R
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
L
P
M
D
C
F
T
M
P
S
YSRKSLWVIN
S
A
L
R
I
K
I
L
C
A
T
YVNVND
K
I
Y
V
R
T
G
I
Y
H
G
G
E
P
L
C
D
N
V
N
T
Q
RVPCS
N
P
R
W
N
E
W
L
N
Y
D
I
Y
I
P
DLPRA
A
R
L
C
L
S
I
C
---
S
V
K
E
E
---
H
C
P
L
-
A
-
W
G
N
I
N
L
F
D
Y
----
T
D
T
L
V
S
G
K
M
A
L
N
L
W
P
V
PHG
L
E
D
L
L
N
P
I
G
V
T
G
S
N
P
N
K
E
T
P
---
C
L
E
L
E
-
F
D
W
F
S
S
V
---
V
K
F
P
D
M
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
YSHAGLSNRLARDN
E
L
R
-----
E
N
D
K
E
Q
L
K
A
I
S
T
RDPL
S
E
I
T
E
Q
--
E
K
D
----------------------------
F
L
W
---
S
H
R
H
Y
---------------
C
-
V
T
------
I
P
E
I
L
P
K
L
L
L
S
V
----
K
W
N
S
R
D
E
V
A
Q
M
Y
C
--------------
L
V
K
D
WPPIK
P
E
Q
A
M
E
L
L
D
C
N
----
Y
--
P
D
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
YEQYLD
N
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
F
F
-------
W
-------
H
---
L
K
S
E
M
H
N
K
T
V
----
S
Q
R
F
G
L
---------
L
L
E
S
Y
C
R
A
C
G
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
T
D
I
L
-------------------
K
Q
E
K
K
D
E
---
T
-----
Q
K
V
Q
M
K
F
L
V
E
Q
M
R
R
P
D
F
M
D
A
L
--
Q
G
F
L
S
P
L
N
P
A
H
Q
L
G
N
LRLEE
C
R
I
M
S
SAKRP
L
W
L
N
W
E
N
P
DI
M
S
---
E
L
L
F
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
-----------
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
GLDLRMLP
Y
G
C
L
S
I
GDC
V
G
L
I
E
--
V
V
R
N
--
S
H
T
I
M
Q
I
Q
C
K
G
F
N
S
H
T
-------
L
H
Q
W
L
K
--
D
K
N
KG
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
---
A
G
Y
C
V
A
T
F
I
L
GIGDRHNSN
I
M
V
K
DD
G
Q
L
F
H
I
-------
D
--
F
G
H
F
LDRVPFVL
T
-------------------
Q
D
F
L
I
V
I
S
T
K
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
GSGMPELQSFDDIA
Y
I
R
K
T
L
ALDKT
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
DA
36
Fugue
75.59
19%
-120
* C2 *
4UFC
1
?
A:
[21-807]
----------------------
D
L
K
L
W
Y
S
Q
P
A
Q
N
W
S
E
------------------------
A
L
P
I
G
N
S
R
L
G
A
M
V
Y
----
G
G
I
E
R
E
E
L
Q
L
N
E
ETFW
A
G
S
P
Y
NN
N
N
P
N
A
V
H
V
L
P
V
V
R
K
L
I
F
E
G
R
N
K
E
A
Q
R
L
I
D
A
N
F
L
TQQH
G
M
S
Y
L
T
L
G
S
-
L
Y
-
L
E
FPEHQNGSG
F
Y
R
D
L
N
L
ENA
T
T
T
T
---
R
----
Y
Q
-
V
D
D
V
T
Y
T
R
T
T
F
A
S
F
T
D
N
V
I
I
M
H
I
--
K
A
S
K
A
N
A
L
N
F
T
I
A
Y
N
C
P
L
V
H
K
V
N
----------------
V
Q
N
D
Q
------
L
T
V
T
C
Q
G
K
E
Q
E
G
L
K
A
A
L
------------------
R
A
E
C
Q
I
Q
------
V
K
T
N
G
T
L
---
R
P
A
G
N
T
L
Q
I
N
E
G
-
T
-
E
A
T
L
Y
I
S
A
A
TNYV
N
Y
Q
D
V
S
-----
A
-------
D
E
S
H
R
T
S
E
Y
L
K
R
A
M
Q
I
P
Y
E
K
---
A
L
K
N
H
-
I
A
Y
Y
K
K
Q
F
D
R
V
R
L
---
T
L
P
A
G
K
A
S
Q
L
E
T
P
K
R
I
E
---------------
N
F
G
NGED
M
A
M
A
A
L
L
F
H
Y
G
R
-------
Y
L
L
I
--
S
S
S
QPGGQPANLQGIWNNSTHAPWDSKYTIN
I
N
T
---
E
M
N
Y
W
---------------
P
-
A
E
VTNLSE
T
H
S
P
L
F
S
M
L
K
D
L
----
S
V
T
G
A
E
T
A
R
T
M
Y
D
C
R
G
W
V
A
H
HNTDLWR
I
C
--------
G
V
V
D
F
A
A
A
G
M
----
W
--
P
-------
S
G
G
A
W
L
A
Q
H
----
I
W
Q
H
Y
L
F
T
G
N
K
E
F
------
L
K
E
Y
Y
P
I
L
K
G
T
A
---
Q
F
Y
M
D
F
L
-------
V
-------
E
HPV
Y
K
W
L
V
V
S
P
S
V
SPEH
G
P
---
I
TAGC
T
M
D
N
Q
I
A
F
D
A
L
H
N
T
L
L
A
S
Y
I
A
G
E
A
P
S
F
Q
D
S
L
K
Q
T
L
E
K
L
P
P
M
Q
I
G
KHNQLQEWLEDID
N
P
K
D
E
H
R
H
I
S
H
LYGLY
P
S
N
Q
I
S
P
Y
S
N
P
E
-----
L
F
Q
A
A
R
N
T
L
L
Q
R
G
D
K
A
T
G
---------
W
S
I
G
-----
W
K
V
N
F
W
A
R
--
M
L
D
G
N
H
A
F
Q
I
I
K
N
M
I
Q
L
L
P
N
D
H
L
A
K
E
Y
PNGRTYPNMLD
A
H
P
P
F
Q
I
D
G
N
F
G
Y
------------
T
A
G
V
---
A
E
M
L
L
--
Q
S
H
D
--
G
A
------
V
H
L
L
P
A
L
P
DAWE
E
G
S
V
K
G
L
V
A
RG
N
F
T
------
V
D
M
D
W
K
N
N
V
L
---
N
K
A
I
I
R
S
N
I
----------------
G
S
T
L
R
I
R
S
Y
V
P
L
K
G
--
K
G
L
K
--------
Q
V
N
GKECSNRLF
A
T
T
P
I
K
Q
P
L
V
A
K
G
V
S
A
Q
S
P
K
L
Q
K
V
Y
E
Y
D
I
E
TKAG
K
T
Y
I
V
N
T
I-------------------------------------------------
5
PsiBlast_PDB
75.06
23%
-120
- C3 -
3L1L
2
ADIC_ECO57
A:
[21-324]
-----------------------------------------------------------------
G
A
I
-
M
G
S
G
V
F
L
L
P
-
A
N
L
A
--
S
---------
T
G
G
I
A
--
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
-----
Y
A
R
R
C
F
G
P
-
F
L
-
G
----------
Y
Q
T
N
V
L
Y
-----
W
L
---
A
----
C
W
-
I
G
N
I
A
M
V
------------
V
I
G
----
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
W
V
L
----
T
----------------
I
T
C
V
V
------
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
---------------
A
V
A
T
-----------
V
L
A
L
I
---
P
I
V
G
----
I
----
A
-
V
F
G
W
-----------------
F
W
F
R
-------
G
E
T
Y
M
A
-------------
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-----
S
A
S
P
F
G
D
A
A
R
M
A
----
L
G
D
T
A
G
---
A
I
V
S
--------------
F
C
--------
A
-
A
A
G
C
L
G
S
L
G
G
W
T
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
------
T
P
V
A
G
L
I
I
V
G
I
L
---
M
T
I
F
Q
L
S
-------
S
-------
I
---
S
P
N
A
T
K
E
F
G
L
----
V
S
---
S
---------
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
-------------------
A
V
T
T
I
A
F
L
Y
C
I
-----
W
A
V
V
G
S
G
A
K
E
V
M
-----
W
S
F
V
--
T
L
M
V
I
T
A
M
Y
A
L
N
---------
Y
N
R
L
-----
H
K
N
P
Y
P
L
D
--
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
74.32
13%
-120
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
--------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
----------------
V
Y
E
Y
P
T
F
A
T
-
S
G
F
S
L
V
F
F
L
-
L
L
G
G
I
L
W
---------
F
I
P
V
G
--
L
C
A
A
E
M
A
T
-----------------
V
D
G
W
G
V
F
A
-----
W
V
S
N
T
L
G
P
-
R
W
-
G
----------
F
A
A
I
S
F
G
-----
Y
L
---
Q
----
I
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
---
I
L
K
-----------------
W
P
A
L
N
E
D
P
I
----------------
T
K
T
I
A
------
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
---------------
R
I
--
A
K
V
------
G
F
F
A
G
I
L
---
L
P
A
F
----
I
L
I
A
-
L
-
A
A
I
Y
------------------------------
L
H
T
F
F
P
D
F
S
K
V
------
G
---
T
L
V
V
F
-
V
A
F
I
L
S
Y
---
M
G
V
---
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
---------------
P
L
A
-----
M
L
L
L
M
V
A
A
I
C
L
-------
S
S
V
G
--
G
L
S
----------------------------
I
A
M
---
V
I
P
G
N
---------------
E
-
I
N
------
L
S
A
G
V
M
Q
T
F
T
V
L
M
SHV
A
P
E
I
E
W
T
V
R
V
I
S
A
--------------
L
L
--------
L
L
G
V
L
A
E
I
A
S
----
W
I
V
G
-------
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
-----
V
T
L
V
I
S
Q
L
V
I
T
S
---
I
A
L
I
I
L
T
-------
N
TGGG
N
N
M
S
---
F
L
I
A
L
A
L
T
V
V
----
I
Y
---
L
---------
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
---------------------------------------------------------------------------------------------------------------------------------
P
G
G
-----------
K
G
V
K
L
V
V
A
I
V
G
L
L
------------
T
S
I
M
---
A
F
I
V
S
--
F
L
P
P
--
D
------------------------------------------
N
I
Q
G
D
S
T
---
D
M
Y
V
E
L
L
V
V
----------------
S
F
L
V
V
L
-------
A
--
L
P
F
I
--------
L
-------------------
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
---------------------------------------------------------------------
9
PsiBlast_PDB
45.18
30%
-41
- C3 -
3IL4
1
FABH_ENTFA
A:
[75-168]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
A
T
V
T
P
D
F
N
------
M
P
S
V
A
C
Q
V
Q
G
A
I
---
G
A
T
E
A
F
A
-------
F
-------
D
---
I
S
A
A
C
S
--------
G
F
---
V
---------
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
---
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
-------------------
D
W
T
D
R
S
T
A
V
L
F
-----
G
D
G
A
A
G
V
L
I
E
A
A
-----
E
T
P
H
--
F
L
N
E
K
L
Q
A
D
G
Q
R
---------
W
T
A
L
-----
T
S
G
Y
T
I
N
E
--
S
P
---
F
Y
Q
G
H
K
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
-----------
K
D
V
S
Q
N
I
L
S
L
V
T
D
------------
E
T
V
D
---
Y
L
L
L
H
--
Q
A
S
V
--
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
-------
F
L
T
N
M
D
--
K
Y
G
------
N
T
S
A
A
S
I
P
I
L
---
L
D
E
A
V
E
N
G
T
----------------
L
I
L
G
S
Q
-------
Q
--
R
V
V
L
--------
T
-------------------
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
--------------------------------------------------------------------
10
PsiBlast_PDB
43.59
30%
-39
- C3 -
3IL5
1
FABH_ENTFA
A:
[96-189]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
A
T
V
T
P
D
F
N
------
M
P
S
V
A
C
Q
V
Q
G
A
I
---
G
A
T
E
A
F
A
-------
F
-------
D
---
I
S
A
A
C
S
--------
G
F
---
V
---------
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
---
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
-------------------
D
W
T
D
R
S
T
A
V
L
F
-----
G
D
G
A
A
G
V
L
I
E
A
A
-----
E
T
P
H
--
F
L
N
E
K
L
Q
A
D
G
Q
R
---------
W
A
A
L
-----
T
S
G
Y
T
I
N
E
--
S
P
---
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
-----------
A
I
K
D
V
S
Q
N
I
L
S
L
V
------------
T
D
E
T
---
V
D
Y
L
L
--
L
H
Q
A
--
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
-------
E
K
F
L
T
N
--
M
D
K
------
Y
G
N
T
S
A
A
S
I
P
---
I
L
L
D
E
A
V
E
N
----------------
G
T
L
I
L
G
-------
S
--
Q
Q
R
V
--------
V
-------------------
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
------------------------------------------------------------------
8
PsiBlast_PDB
43.12
27%
-45
- C3 -
3OB6
1
ADIC_ECOLI
A:
[190-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V
-----
S
A
S
P
F
G
D
A
A
R
M
A
----
L
G
D
T
A
G
---
A
I
V
S
--------------
F
C
--------
A
-
A
A
G
C
L
G
S
L
G
G
W
T
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
------
T
P
V
A
G
L
I
I
V
G
I
L
---
M
T
I
F
Q
L
S
-------
S
-------
I
---
S
P
G
L
V
S
S
V
S
V
----
I
F
---
T
---------
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
-------------------
F
L
Y
C
I
W
A
V
V
G
S
-----
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
V
I
T
--
A
M
Y
A
L
N
Y
N
R
L
H
K
---------
N
P
Y
P
-----
L
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.16
27%
-69
- C3 -
3NCY
-
ADIC_SALTY
A:
[190-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
A
---------------
A
-
L
R
V-----
S
A
S
P
F
G
D
A
A
R
M
A
----
L
G
D
T
A
G
---
A
I
V
S
--------------
F
C
--------
A
-
A
A
G
C
L
G
S
L
G
G
W
T
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
------------
T
P
V
A
G
L
L
I
V
G
V
L
---
M
T
I
F
Q
F
S
-------
S
-------
M
---
S
P
N
A
A
K
E
F
G
L
----
V
S
---
S
---------
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
L
Y
L
-------------------
L
I
T
F
V
A
F
V
Y
C
I
-----
W
A
V
I
G
S
G
A
K
E
V
M
-----
W
S
F
V
--
T
L
M
V
I
T
A
L
Y
A
L
N
---------
Y
N
R
I
-----
H
K
N
P
Y
P
L
D
--
A
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
39.96
25%
-82
- C3 -
3ZUM
6
RCEL_RHOSH
L:
[75-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
A
P
L
A
K
G
G
-----------
L
W
Q
I
I
------
T
I
------------
C
A
T
G
---
A
F
V
S
W
AL
R
E
V
E
IC
R
K
L
G
I
G
Y
H
I
P
F
A
F
A
F
A
-------
I
L
A
-
Y
L
--
T
L
V
------
L
F
R
P
V
M
M
G
A
W
GYA
A
P
Y
G
I
W
T
H
L
----------------
D
W
V
S
N
T
-------
G
YT
Y
G
N
F
--------
H
-------------------
Y
N
P
A
H
M
I
A
I
S
F
F
F
T
N
A
L
A
L
A
L
H
-------------------------------------------------------------
24
HHSearch
37.44
14%
-78
- C3 -
3DH4
1
?
A:
[53-355]
-----------------------------------------------
G
K
S
L
P
W
----
W
A
V
G
A
S
L
I
A
A
N
-
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-----------
I
G
L
A
I
--
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
-----
F
V
E
K
R
F
N
K
-
K
L
-
K
----------
T
I
L
A
V
F
W
-----
I
S
---
L
----
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
---
I
L
G
I
--
P
--------------
L
---
M
--
Y
----------------
S
I
L
G
L
------
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
---------------
V
I
Q
V
F
F
L
------
V
L
G
G
F
M
T
---
T
Y
M
A
----
V
S
F
I
-
G
G
T
D
G
W
F
A
G
V
S
----
K
M
V
D
A
-
A
P
--
G
H
-------
F
E
M
I
---
L
D
Q
S
N
P
Q
Y
M
N
L
P
G
IAV
L
I
G
G
L
W
V
A
N
L
Y
Y
W
---
G
F
N
---
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
---------------
Q
K
G
-----
I
V
F
A
A
F
L
K
L
I
V
-------
P
F
L
V
--
V
L
P
----------------------------
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
N
------
A
D
K
A
Y
P
W
L
T
-
Q
F
----
L
P
V
G
V
K
G
V
V
F
A
A
L
--------------
A
A
--------
A
I
V
S
S
L
A
S
M
L
----
N
--
S
-------
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
------
V
N
V
G
R
T
A
A
V
V
A
L
---
I
I
A
C
L
I
A
-------
P
-------
M
---
L
G
G
I
G
Q
A
F
Q
Y
----
I
Q
---
E
---------
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
I
G
V
V
A
-------------------
S
I
P
F
A
L
F
L
K
F
M
-----
P
L
S
M
P
F
M
D
Q
M
L
Y
-----
T
L
L
F
--
T
M
V
V
I
A
F
T
S
L
S
T
---------
S
I
N
D
-----
D
D
P
K
G
I
S
V
--
T
S
---
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
-----------
L
Y
T
L
F
W
V
L
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
36.52
26%
-67
- C3 -
1Z9J
6
RCEL_RHOSH
A:
[75-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
A
P
L
A
K
G
G
-----------
L
W
Q
I
I
------
T
I
------------
C
A
T
G
---
A
F
V
S
W
A
L
R
E
V
E
I
C
R
K
L
G
I
G
Y
H
I
P
F
A
F
A
F
A
-------
I
L
A
Y
L
T
--
H
V
-------
L
F
R
P
V
M
M
G
A
W
GYA
F
P
Y
G
I
W
T
H
L
----------------
D
W
V
S
N
T
-------
G
Y
T
Y
G
N
F
--------
H
-------------------
Y
N
P
A
H
M
I
A
I
S
F
F
F
T
N
A
L
A
L
A
L
H
-------------------------------------------------------------
6
PsiBlast_PDB
36.16
27%
-52
- C3 -
3LRB
-
ADIC_ECO57
A:
[190-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
---------------------------------------------
T
A
G
---
A
I
V
S
--------------
F
C
--------
A
-
A
A
G
C
L
G
S
L
G
G
W
T
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
------
T
P
V
A
G
L
I
I
V
G
I
L
---
M
T
I
F
Q
L
S
-------
S
-------
I
---
S
P
N
A
T
K
E
F
G
L
----
V
S
---
S
---------
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
-------------------
A
V
T
T
I
A
F
L
Y
C
I
-----
W
A
V
V
G
S
G
A
K
E
V
M
-----
W
S
F
V
--
T
L
M
V
I
T
A
M
Y
A
L
N
---------
Y
N
R
L
-----
H
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
35.80
27%
-45
- C3 -
3LRC
-
ADIC_ECO57
A:
[190-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
W
S
F
---
I
G
V
---
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
---------------
P
I
A
-----
T
I
G
G
V
L
I
A
A
V
C
-------
Y
V
L
S
--
T
T
A
----------------------------
I
M
G
---
M
I
P
N
---------------------------------------------
T
A
G
---
A
I
V
S
--------------
F
C
--------
A
-
A
A
G
C
L
G
S
L
G
G
W
T
L
--
L
-------
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-
K
A
G
------
T
P
V
A
G
L
I
I
V
G
I
L
---
M
T
I
F
Q
L
S
-------
S
-------
I
---
S
P
N
A
T
K
E
F
G
L
----
V
S
---
S
---------
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
-------------------
A
V
T
T
I
A
F
L
Y
C
I
-----
W
A
V
V
G
S
G
A
K
E
V
M
-----
W
S
F
V
--
T
L
M
V
I
T
A
M
Y
A
L
N
---------
Y
N
R
L
-----
H
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------