@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EAA3_HUMAN: (2015-12-07 )
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120..---.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....--------..230-------........240.......250.......260.......270.......280.......290.......300.......310--........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420......---.------430-----.------...------....440.......450.......460.......470.......480.......490.......500.......510.......520..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKPARKGC
E
W
K
R
F
L
KNN
W
V
L
L
S
T
V
A
A
V
V
L
G
IT
T
G
V
L
V
REHS
N
L
S
T
L
E
K
F
Y
F
AF
P
G
E
I
L
M
R
M
L
K
L
I
I
L
P
L
I
I
S
S
M
I
T
G
V
A
A
LDSNVSG
K
I
G
L
R
A
V
V
Y
Y
F
C
T
T
L
I
A
V
I
L
G
I
V
L
V
V
SIKPG
V
T
Q
K
V
---
G
E
I
ARTGSTPEV
S
T
V
D
A
M
L
D
L
I
R
N
M
F
P
E
N
L
V
Q
A
C
F
Q
Q
Y
K
T
K
R
EEVKPPSDPEMNM
T
E
E
S
F
T
A
V
M
T
T
AISKNKT
K
E
Y
K
I
V
G
M
YSD
G
I
N
V
L
G
L
I
V
F
C
L
V
F
G
L
V
I
G--------KMGE--------KG
Q
I
L
V
D
F
F
N
A
L
S
D
A
T
M
K
I
V
Q
I
I
M
C
Y
M
P
L
G
I
L
F
L
IAG
K
I
I
EV
E
D
W
E
I
F
R
K
L
G
L
Y
M
A
T
V
L
T
G
L
A
I
H
S
I
V
I
L
P
L
I
Y
F
I
VVRK---N
P
F
R
F
A
M
G
M
A
Q
A
L
L
T
A
L
M
ISSSS
A
T
L
P
V
T
F
R
CAEEN
N
Q
V
D
K
R
I
T
R
F
V
LPVG
A
T
INM
D
G
T
A
L
Y
E
A
V
A
A
V
F
I
A
QLNDLDLGIG
Q
I
I
T
I
S
I
T
ATSASIGAAGVPQ
A
G
L
V
T
M
V
I
V
L
S
AVGL---P------AE------
D
------
V
T
L
------
I
I
A
V
D
W
L
L
D
R
F
R
T
M
V
N
V
L
G
D
A
F
G
T
G
I
V
E
K
L
S
K
K
E
L
E
Q
MDVSSEV
N
I
V
N
P
F
A
L
E
S
T
ILDNEDSDT
K
K
SYVNG
G
F
AVDKSD
T
I
S
FTQTSQF
110
Fugue
92.66
35%
-125
* C13 *
4OYF
-
?
A:
[9-416]
----------------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
---------------------------
I
H
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
---------
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
--------------------
E
--------
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
-
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
LTD
P
N
V
A
A
------
A
------
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
57
PsiBlast_CBE
91.68
32%
-129
- C13 -
4KY0
1
?
B:
[10-425]
--------------
L
-
D
Y
P
V
L
W
K
I
L
W
G
L
V
L
G
A
V
F
G
-
L
I
A
G
H
F
G
Y
A
G
A
V
K
T
Y
I
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
L
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
A
T
S
A
M
A
V
F
F
G
L
I
V
G
R
L
F
N
V
G
A
N
V
N
L
---
G
--
S
G
T
--------------------
P
P
S
L
V
Q
T
L
L
N
I
V
---------
P
T
N
P
F
A
S
L
A
K
G
----------------------------
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
RNE
E
R
V
R
K
--------
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
R
V
V
G
P
L
A
K
V
V
G
A
V
Y
T
G
L
F
L
Q
-
I
V
I
T
Y
F
I
L
L
K
V
F
G
I
---
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
------
G
S
------
P
------
V
A
L
A
Y
A
M
--
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
A
K
-
T
E
K
E
L
D
E
S
K
W
I
------------------------------------------------
26
PsiBlast_CBE
91.68
31%
-149
- C13 -
3V8F
1
?
B:
[6-414]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
------
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
15
PsiBlast_PDB
91.56
32%
-131
- C13 -
4KY0
1
?
A:
[9-425]
-------------
Y
L
-
D
Y
P
V
L
W
K
I
L
W
G
L
V
L
G
A
V
F
G
-
L
I
A
G
H
F
G
Y
A
G
A
V
K
T
Y
I
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
L
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
A
T
S
A
M
A
V
F
F
G
L
I
V
G
R
L
F
N
V
G
A
N
V
N
L
---
G
--
S
G
T
G
K
A
I
-------------------
L
V
Q
T
L
L
N
I
V
---------
P
T
N
P
F
A
S
L
A
K
G
----------------------------
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
RNE
E
R
V
R
K
--------
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
R
V
V
G
P
L
A
K
V
V
G
A
V
Y
T
G
L
F
L
Q
-
I
V
I
T
Y
F
I
L
L
K
V
F
G
I
---
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
------
G
S
------
P
------
V
A
L
A
Y
A
M
--
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
A
K
-
T
E
K
E
L
D
E
S
K
W
I
S
-----------------------------------------------
56
PsiBlast_CBE
91.07
32%
-126
- C13 -
4KY0
2
?
C:
[10-425]
--------------
L
-
D
Y
P
V
L
W
K
I
L
W
G
L
V
L
G
A
V
F
G
-
L
I
A
G
H
F
G
Y
A
G
A
V
K
T
Y
I
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
L
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
A
T
S
A
M
A
V
F
F
G
L
I
V
G
R
L
F
N
V
G
A
N
V
N
L
---
G
--
S
G
T
G
K
A
I
E
A
Q
-------------
P
P
S
L
V
Q
T
L
L
N
I
V
---------
P
T
N
P
F
A
S
L
A
K
G
----------------------------
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
RNE
E
R
V
R
K
--------
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
R
V
V
G
P
L
A
K
V
V
G
A
V
Y
T
G
L
F
L
Q
-
I
V
I
T
Y
F
I
L
L
K
V
F
G
I
---
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
------
G
S
------
P
------
V
A
L
A
Y
A
M
--
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
A
K
-
T
E
K
E
L
D
E
S
K
W
I
S
H
----------------------------------------------
58
PsiBlast_CBE
91.02
31%
-137
- C13 -
2NWL
2
?
C:
[25-414]
----------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AV
G
G
Q
Q
F
Q
P
----
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
8
PsiBlast_PDB
90.86
31%
-136
- C13 -
4OYG
1
?
A:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
45
PsiBlast_CBE
90.74
31%
-152
- C13 -
3V8G
1
?
B:
[6-414]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
-------
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
C
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
24
PsiBlast_CBE
90.53
31%
-144
- C13 -
3KBC
1
?
B:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
23
PsiBlast_CBE
90.40
31%
-144
- C13 -
3KBC
1
?
C:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
37
PsiBlast_CBE
90.35
31%
-136
- C13 -
4OYG
1
?
E:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
25
PsiBlast_CBE
90.35
31%
-150
- C13 -
3V8F
1
?
C:
[7-414]
-------
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
------
P
N
V
AAAYAC
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
38
PsiBlast_CBE
90.32
31%
-135
- C13 -
4OYG
1
?
D:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
17
PsiBlast_PDB
90.29
31%
-138
- C13 -
2NWL
2
?
A:
[25-414]
----------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
-----
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
99
HHSearch
90.28
34%
-141
- C13 -
2NWL
2
?
A:
[10-416]
-----------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
-
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
---
A
V
G
G
Q
---
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
-------------------------------------------------
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
-
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
I
-
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
D
P
N
V
A
A
A
------
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
16
PsiBlast_PDB
90.27
31%
-146
- C13 -
4OYE
-
?
A:
[5-407]
-------------------
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
------
H
L
A
V
G
G
-----------------------------------
A
---
P
P
-----------
L
V
H
I
L
L
D
I
V
P
T
N
P
------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
3
PsiBlast_PDB
90.25
31%
-149
- C13 -
3V8F
1
?
A:
[7-414]
-------
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
------
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
2
PsiBlast_PDB
90.08
31%
-144
- C13 -
3KBC
1
?
A:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
32
PsiBlast_CBE
90.07
31%
-140
- C13 -
2NWX
2
?
C:
[12-414]
------------
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
----
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
36
PsiBlast_CBE
90.03
31%
-136
- C13 -
4OYG
1
?
F:
[6-416]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
---------------------------------------------------------
59
PsiBlast_CBE
89.98
31%
-138
- C13 -
2NWL
2
?
B:
[25-414]
----------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG---------
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
33
PsiBlast_CBE
89.81
31%
-140
- C13 -
2NWX
2
?
B:
[12-414]
------------
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG---------
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
10
PsiBlast_PDB
89.73
31%
-140
- C13 -
4IZM
1
?
A:
[13-414]
-------------
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVA
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
5
PsiBlast_PDB
89.27
31%
-142
- C13 -
2NWW
1
?
A:
[10-414]
----------
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
34
PsiBlast_CBE
89.20
31%
-140
- C13 -
2NWW
1
?
C:
[10-414]
----------
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
35
PsiBlast_CBE
88.60
31%
-141
- C13 -
2NWW
1
?
B:
[10-414]
----------
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
1
PsiBlast_PDB
88.58
31%
-154
- C13 -
4X2S
1
?
A:
[12-414]
------------
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
46
PsiBlast_CBE
88.19
31%
-142
- C13 -
4IZM
1
?
C:
[13-414]
-------------
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
6
PsiBlast_PDB
88.19
31%
-142
- C13 -
2NWX
2
?
A:
[12-414]
------------
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
-----
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
22
PsiBlast_CBE
87.58
31%
-149
- C13 -
4X2S
1
?
B:
[6-414]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
P
N
V
A
A
A
Y
A
M
------
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------
21
PsiBlast_CBE
87.29
31%
-149
- C13 -
4X2S
1
?
C:
[6-414]
------
K
Y
I
E
Y
P
V
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
------------------------------------------------------
47
PsiBlast_CBE
86.78
31%
-137
- C13 -
4IZM
1
?
B:
[13-414]
-------------
L
Q
K
---
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-----
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
AVG
G
Q
Q
F
Q
P
H
Q
A
P
P
L
--
V
H
I
L
L
D
I
V
-------------------------
P
T
N
P
---------------------------
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
-
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
------
L
T
------
D
PNVAAA
Y
A
M
------
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
----------------------------------------------------------