@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EAA5_HUMAN: (2015-12-07 )
MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEELPAASLNHCTIQISELETNV
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..-.....220.......230.....--------..240-------........250.......260.......270.......280.......290.......300.......310.......320---.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440------.------......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
P
H
A
I
L
A
R
G
R
D
V
C
R
RN
G
L
L
I
L
S
V
L
S
V
I
V
G
C
L
L
G
F
F
L
R
TRRLSPQEI
S
Y
FQF
P
G
E
L
L
M
R
M
L
K
M
M
I
L
P
L
V
V
S
S
L
M
S
G
L
A
SLDAKTSSRL
G
V
L
T
V
A
Y
Y
L
W
T
T
F
M
A
V
I
V
G
I
F
M
V
S
IIHPGSAAQKETTEQSGKPIM
S
S
A
D
A
L
L
D
L
I
R
N
MF
P
A
N
L
V
E
A
T
F
K
Q
YRTKTTPVVKSPKVAPEEAPP
R
R
I
L
I
Y
G
VQEENGS
H
V
Q
N
F
A
L
DLTPPPE
V
V
Y
KSEP-GTSDG
M
N
V
L
G
I
V
F
F
S
A
T
M
G
I
M
LG--------RMGD--------SGA
P
L
V
S
F
C
Q
C
L
N
E
S
V
M
K
I
V
A
V
A
V
W
Y
F
P
F
G
I
V
F
L
I
A
G
K
ILEMDD
P
R
A
V
G
K
KLG
F
Y
S
V
T
V
V
C
G
L
V
L
H
G
L
F
I
L
P
L
L
Y
F
F
ITKK---N
P
I
V
F
I
R
G
I
L
Q
A
L
L
I
A
L
ATSSSS
A
T
L
P
I
T
F
K
C
L
LENN
H
I
D
R
R
I
A
R
F
VLPVG
A
T
INM
D
G
T
A
L
Y
E
A
V
A
A
I
F
I
AQVNNYELDFG
Q
I
I
T
I
S
I
T
A
T
AASIGAAGIPQ
A
G
L
V
T
M
V
I
V
L
TSVGLPTD------
D
------
I
T
L
I
I
A
V
D
W
A
L
D
R
F
R
T
M
I
N
V
L
G
D
A
L
A
A
G
I
M
A
H
I
C
R
K
D
F
ARDTGTEKLLPCETKP
V
S
L
Q
E
I
V
A
A
QQN
G
C
V
K
S
V
A
E
A
S
ELTLGPTCPHHV
P
V
Q
VEQDEELPAASL
N
H
C
T
I
Q
I
S
E
LETNV
68
Fugue
92.32
37%
-135
- C4 -
4OYF
-
?
A:
[9-416]
-----------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
----
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
-------------------------------------------------------------------
G
I
H
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
V
P
T
------
N
P
F
-
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
--
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
-
I
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-----------
T
E
------------------------------------------------------------------------
59
HHSearch
91.23
36%
-142
- C4 -
2NWL
2
?
A:
[10-416]
----------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
--
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
---------------------------------------------------------------
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
-
V
-
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
-
I
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
-
E
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
D
P
N
V
A
A
A
------
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
32
PsiBlast_CBE
89.24
32%
-151
- C4 -
3V8G
1
?
E:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
---------------------------------------------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
15
PsiBlast_PDB
89.13
32%
-140
- C4 -
4OYE
-
?
A:
[9-406]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
--------------------------------------------------
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
88.79
32%
-142
- C4 -
4OYF
-
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
-------------------------------------------------------------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
88.79
32%
-139
- C4 -
2NWX
2
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
------------------
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
35
PsiBlast_CBE
88.74
32%
-151
- C4 -
3V8G
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
-------------------------------------
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
28
PsiBlast_CBE
88.62
32%
-142
- C4 -
2NWX
2
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
----------------------------------------------------
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
88.44
32%
-147
- C4 -
4P1A
-
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
--------------------------------------------------------------------------------
13
PsiBlast_PDB
88.40
32%
-143
- C4 -
4P6H
-
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
27
PsiBlast_CBE
88.36
32%
-138
- C4 -
2NWX
2
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
----
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
40
PsiBlast_CBE
88.15
32%
-145
- C4 -
3KBC
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
9
PsiBlast_PDB
88.15
32%
-144
- C4 -
3KBC
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
6
PsiBlast_PDB
87.92
32%
-149
- C4 -
3V8G
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
52
PsiBlast_CBE
87.90
32%
-136
- C4 -
4OYG
1
?
F:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
55
PsiBlast_CBE
87.89
32%
-136
- C4 -
4OYG
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
10
PsiBlast_PDB
87.86
32%
-146
- C4 -
4P19
-
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
-------------------------------------------------------------------------------
41
PsiBlast_CBE
87.85
32%
-145
- C4 -
3KBC
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
33
PsiBlast_CBE
87.82
32%
-149
- C4 -
3V8G
1
?
D:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
12
PsiBlast_PDB
87.81
32%
-149
- C4 -
4P3J
-
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
----------------------------------------------------------------------------------
14
PsiBlast_PDB
87.75
32%
-134
- C4 -
2NWL
2
?
A:
[25-413]
---------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
------------------
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
37
PsiBlast_CBE
87.67
32%
-144
- C4 -
3V8F
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
87.63
32%
-138
- C4 -
2NWW
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
7
PsiBlast_PDB
87.62
32%
-143
- C4 -
3V8F
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
36
PsiBlast_CBE
87.44
32%
-144
- C4 -
3V8F
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
-
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
1
PsiBlast_PDB
87.33
32%
-147
- C4 -
4X2S
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
29
PsiBlast_CBE
87.31
32%
-136
- C4 -
2NWW
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
50
PsiBlast_CBE
87.00
32%
-134
- C4 -
2NWL
2
?
C:
[25-413]
---------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
----
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
51
PsiBlast_CBE
86.78
32%
-136
- C4 -
2NWL
2
?
B:
[25-413]
---------------------------
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
----------------------------------------------------
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
30
PsiBlast_CBE
86.55
32%
-136
- C4 -
2NWW
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
20
PsiBlast_CBE
85.73
32%
-145
- C4 -
4X2S
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
-------------------------------------------------------------------------------
21
PsiBlast_CBE
85.63
32%
-144
- C4 -
4X2S
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
8
PsiBlast_PDB
85.62
32%
-137
- C4 -
4IZM
1
?
A:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVA
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
38
PsiBlast_CBE
84.88
32%
-137
- C4 -
4IZM
1
?
C:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------
39
PsiBlast_CBE
84.81
32%
-133
- C4 -
4IZM
1
?
B:
[16-413]
------------------
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
----
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
------------------------------
Q
F
Q
-------------
P
H
Q
A
P
P
---------------
L
V
H
I
L
L
D
I
V
P
-------
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
E
-
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
----
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
G
-
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------------