@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GDC_HUMAN: (2015-12-08 )
MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN
Atome Classification :
(20 SA)
-----------------------------------.........10..------------------.-----.....20..---......30...--...----------.---------------.40----...--......50------.....--..--------.60.----..--...------.------.-------70---------..-.-----------..-...80.-------.......90----.........100....----------...110.......120..---------------..-----..--.130--.-.----.....-..-----140-....--....150-..----------------.------....----160-.---.--------.....170....-.-..180...---.-...190.-.---.....200.......210--........220...-----------------------...-.230....-----..--------..--240-.....-..-----..---------250..-.----......260--.....--.------..------.---270..-..-.-...280-.-------------......290.......300...--------....310--------........320..-.....330---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MAA
A
T
A
A
A
A
LAAA------------------D-----PPPAMPQAA---GAGGPTTR
R
D
F
--
Y
W
L
----------
R
---------------
S
F
-----
L
AG--
G
I
A
G
C
CAK------TTVA
P
--
L
D
--------
R
V
K
V
----
L
L
--
Q
AH------N------
H
-------
H
Y
---------
K
H
-
L
-----------
G
V
-
F
S
A
L
R
A-------VPQKEG
F
L
-----
G
L
Y
KGN
G
A
M
M
I
R
I
FPY----------G
A
I
Q
F
M
A
F
E
H
Y
K
T
L
I
T
T
K---------------LG-----IS--
G
H
----
V
-
H
----
R
L
M
A
G-SM-----AG--
M
T
A
V
--
I
C
TY
P
L
D
-
M
V
----------------
R
------
V
R
L
A
----
F
Q
V
-K---G--------EHS
Y
T
G
I
I
H
A
F
K
-
T
-
I
Y
AKEG
G
F
---
F
-
G
F
Y
R
G
L
M
-
P
---
T
I
LGMAPYA
G
V
S
F
F
T
FG---
T
L
K
S
VGLSHA
P
T
LL-----------------------GRP-SSD-NP
N
V
-----
L
V
--------
L
K--T---H
V
N
L
L
-CG-----
G
V
---------
A
--
G
A
-
I
----
A
Q
T
ISY
P
----
F
D
V
T
R
--
R
------
R
M
------
Q
---L-GT
V
-
L
P
-
E
-
F
E
K
C
L
T
-
M
-------------
R
D
T
M
K
Y
V
Y
GH
H
G
I
R
K
G
L
Y
RGLS--------
L
N
Y
I
R
C---------IPSQ
A
V
A
F
T
T
Y
E
L
-
M
K
Q
F
FHLN---------------------
4
PsiBlast_PDB
79.84
29%
-78
- C5 -
4C9Q
5
ADT3_YEAST
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------
N
F
-----
L
M
G
--
G
V
S
A
A
I
A
K
------
T
A
A
S
P
--
I
E
--------
R
V
K
I
----
L
I
--
Q
N
Q
------
D
------
E
M
I
K
Q
GTL
D
K
---------
K
Y
-
S
-----------
G
I
-
V
D
C
F
K
R
-------
T
A
K
Q
E
G
L
I
-----
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
-
A
F
K
D
K
I
K
L
M
F
G
F
---------------
K
K
-----
E
---
G
Y
G
K
W
F
A
-
G
----
N
L
A
S
G
-
G
A
-----
A
G
--
A
L
S
L
--
L
F
V
Y
S
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
A
-
K
S-----------
A
R
Q
F
N
G
L
T
D
V
Y
K
-
K
-
T
L
-
K
S
D
G
I
---
A
-
G
L
Y
R
G
F
M
-
P
---
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
---
S
L
K
-------
P
L
------------------------------------
F
-----
L
------------------
A
S
F
L
-
L
G
-----
W
V
---------
V
--
T
T
-
G
----
A
S
T
C
S
Y
P
----
L
D
T
V
R
--
R
------
R
M
------
M
---
M
-
T
S
---
G
-
Q
-
A
V
K
Y
N
G
-
A
-------------
I
D
C
L
K
K
I
V
A
S
E
G
V
-
G
S
L
F
K
G
C
G
--------
A
N
I
L
R
S
---------
V
A
G
A
G
V
I
S
M
Y
D
Q
L
-
Q
M
I
L
F
G
K
----------------------
9
HHSearch
79.71
30%
-79
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------
D
Q
A
L
--
S
F
L
----------
K
---------------
D
F
-----
L
A
G
--
G
V
A
A
A
I
S
K
------
T
A
V
A
P
--
I
E
--------
R
V
K
L
----
L
L
--
Q
V
Q
------
H
------
A
-------
S
K
QISAEK---
Q
Y
-
K
-----------
G
I
-
I
D
C
V
V
R
-------
I
P
K
E
Q
G
F
L
-----
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
---------------
V
D
RHKQ
F
W
R
--
Y
F
----
A
-
G
----
N
L
A
S
G
-
G
A
-----
A
G
--
A
T
S
L
--
C
F
V
Y
P
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
V
-
G
---
K
GAA-----
Q
R
E
F
T
G
L
G
N
C
I
T
-
K
-
I
-
F
K
S
D
G
L
---
R
-
G
L
Y
Q
G
F
N
-
V
---
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
G
M
L
P
D
P
K
N
-----------------------------------------------------
V
H
--
I
---
I
V
S
W
M
-
I
A
-----
Q
T
---------
V
--
T
A
-
V
----
A
G
L
V
S
Y
P
----
F
D
T
V
R
--
R
------
R
M
------
M
---
M
-
Q
S
G
-
R
K
G
A
-
D
I
M
Y
T
G
-
T
-------------
V
D
C
W
R
K
I
A
K
D
E
G
-
P
K
A
F
F
K
G
A
W
--------
S
N
V
L
R
G
---------
M
G
-
G
A
F
V
L
V
L
Y
D
E
-
I
----------------------------
18
Fugue
78.44
28%
-78
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------
D
Q
A
L
--
S
F
L
----------
K
---------------
D
F
-----
L
A
G
--
G
V
A
A
A
I
S
K
------
T
A
V
A
P
--
I
E
--------
R
V
K
L
----
L
L
--
Q
V
Q
------
H
ASKQIS
A
-------
E
K
---------
Q
Y
-
K
-----------
G
I
-
I
D
C
V
V
R
-------
I
P
K
E
Q
G
F
L
-----
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
---------------
V
D
RHKQ
F
W
R
--
Y
F
----
A
-
G
----
N
L
A
S
G
-
G
A
-----
A
G
--
A
T
S
L
--
C
F
V
Y
P
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
V
-
G
KGA
A
--------
Q
R
E
F
T
G
L
G
N
C
I
T
-
K
-
I
F
K
S
D
G
-
L
---
R
-
G
L
Y
Q
G
F
N
-
V
---
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
G
M
L
P
D
P
K
N
V
-----------------------------------------------------
H
--
I
---
I
V
S
W
M
-
I
A
-----
Q
T
---------
V
--
T
A
-
V
----
A
G
L
V
S
Y
P
----
F
D
T
V
R
--
R
------
R
M
------
M
---
M
Q
S
G
R
-
K
G
-
A
-
D
I
M
Y
T
G
-
T
-------------
V
D
C
W
R
K
I
A
K
D
E
G
-
P
K
A
F
F
K
G
A
W
--------
S
N
V
L
R
G
---------
M
G
G
A
F
V
L
V
L
Y
D
E
I
------------------------------
1
PsiBlast_PDB
77.73
28%
-82
- C5 -
1OKC
10
ADT1_BOVIN
A:
[8-293]
---------------------------------------------------------------------------------------------------
L
----------
K
---------------
D
F
-----
L
A
G
--
G
V
A
A
A
I
S
K
------
T
A
V
A
P
--
I
E
--------
R
V
K
L
----
L
L
--
Q
V
Q
HASKQI
S
------
A
-------
E
K
---------
Q
Y
-
K
-----------
G
I
-
I
D
C
V
V
R
-------
I
P
K
E
Q
G
F
L
-----
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
---------------
V
D
-----
R
H
--
K
Q
----
F
-
W
----
R
Y
F
A
G
-
N
L
A
S
G
G
A
A
G
--
A
T
S
L
--
C
F
V
Y
P
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
V
G
K
---
G
AA------
Q
R
E
F
T
G
L
G
N
C
I
T
-
K
-
I
F
-
K
S
D
G
L
---
R
-
G
L
Y
Q
G
F
N
-
V
---
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
G
M
---------------------------------
L
P
-
D
P
K
-
N
V
H
I
-----
I
------------------
V
S
W
M
-
I
A
-----
Q
T
---------
V
--
T
A
-
V
----
A
G
L
V
S
Y
P
----
F
D
T
V
R
--
R
------
R
M
------
M
---
M
-
Q
S
G
-
R
K
-
G
-
A
D
I
M
Y
T
G
T
-------------
V
D
C
W
R
K
I
A
K
D
E
G
-
P
K
A
F
F
K
G
A
W
--------
S
N
V
L
R
G
---------
M
G
G
-
A
F
V
L
V
L
Y
D
E
-
I
----------------------------
2
PsiBlast_PDB
76.94
28%
-81
- C5 -
2C3E
4
ADT1_BOVIN
A:
[8-293]
---------------------------------------------------------------------------------------------------
L
----------
K
---------------
D
F
-----
L
A
G
--
G
V
A
A
A
I
S
K
------
T
A
V
A
P
--
I
E
--------
R
V
K
L
----
L
L
--
Q
V
Q
HASKQI
S
------
A
-------
E
K
---------
Q
Y
-
K
-----------
G
I
-
I
D
C
V
V
R
-------
I
P
K
E
Q
G
F
L
-----
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
---------------
V
D
-----
R
H
--
K
Q
----
F
-
W
----
R
Y
F
A
G
-
N
L
A
S
G
G
A
A
G
--
A
T
S
L
--
C
F
V
Y
P
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
V
G
K
---
G
AA------
Q
R
E
F
T
G
L
G
N
C
I
T
-
K
-
I
F
-
K
S
D
G
L
---
R
-
G
L
Y
Q
G
F
N
-
V
---
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
---
T
A
K
G
M
---------------------------------
L
P
-
D
P
K
-
N
V
H
I
-----
I
------------------
V
S
W
M
-
I
A
-----
Q
T
---------
V
--
T
A
-
V
----
A
G
L
V
S
Y
P
----
F
D
T
V
R
--
R
------
R
M
------
M
---
M
-
Q
S
G
-
R
K
-
G
-
A
D
I
M
Y
T
G
T
-------------
V
D
C
W
R
K
I
A
K
D
E
G
-
P
K
A
F
F
K
G
A
W
--------
S
N
V
L
R
G
---------
M
G
G
-
A
F
V
L
V
L
Y
D
E
-
I
----------------------------
5
PsiBlast_PDB
71.15
28%
-81
- C5 -
4C9H
5
ADT2_YEAST
A:
[23-301]
--------------------------------------------------------------------------------------------------
F
L
----------
I
---------------
D
F
-----
L
M
G
--
G
V
S
A
A
V
A
K
------
T
A
A
S
P
--
I
E
--------
R
V
K
L
----
L
I
--
Q
N
Q
------
D
------
E
M
L
K
Q
GTL
D
R
---------
K
Y
-
A
-----------
G
I
-
L
D
C
F
K
R
-------
T
A
T
Q
E
G
V
I
-----
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
G
F
K
----------------
K
-----
E
E
--
G
Y
----
A
-
K
W
F
A
G
N
L
A
S
G
-
G
A
-----
A
G
--
A
L
S
L
--
L
F
V
Y
S
L
D
-
Y
A
----------------
R
------
T
R
L
A
----
A
D
S
--------------
A
R
Q
F
N
G
L
I
D
V
Y
K
-
K
-
T
L
-
K
S
D
G
V
---
A
-
G
L
Y
R
G
F
L
-
P
---
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
Y
D
---
S
L
K
---------------------------------------------------
L
------------------
A
S
F
L
-
L
G
-----
W
V
---------
V
--
T
T
-
G
----
A
S
T
C
S
Y
P
----
L
D
T
V
R
--
R
------
R
M
------
M
---
M
-
T
S
---
G
-
Q
-
A
V
K
Y
D
G
-
A
-------------
F
D
C
L
R
K
I
V
A
A
E
G
V
-
G
S
L
F
K
G
C
G
--------
A
N
I
L
R
G
---------
V
A
G
A
G
V
I
S
M
Y
D
Q
L
-
Q
M
I
L
F
G
K
K
---------------------
3
PsiBlast_PDB
70.56
29%
-74
- C5 -
4C9J
4
ADT3_YEAST
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------
N
F
-----
L
M
G
--
G
V
S
A
A
I
A
K
------
T
A
A
S
P
--
I
E
--------
R
V
K
I
----
L
I
--
Q
N
Q
------
D
------
E
M
I
K
Q
GTL
D
K
---------
K
Y
-
S
-----------
G
I
-
V
D
C
F
K
R
-------
T
A
K
Q
E
G
L
I
-----
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
T
----------
Q
A
L
N
F
-
A
F
K
D
K
I
K
L
M
F
G
F
---------------
K
K
-----
E
E
--
G
Y
G
K
W
F
A
-
G
----
N
L
A
S
G
-
G
A
-----
A
G
--
A
L
S
L
--
L
F
V
Y
S
L
D
-
F
A
----------------
R
------
T
R
L
A
----
A
D
A
-
K
S-----------
A
R
Q
F
N
G
L
T
D
V
Y
K
-
K
-
T
L
-
K
S
D
G
I
---
A
-
G
L
Y
R
G
F
M
-
P
---
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
F
D
---
S
L
K
------------------------------------------------------------------------
F
L
-
L
G
-----
W
V
---------
V
--
T
T
-
G
----
A
S
T
C
S
Y
P
----
L
D
T
V
R
--
R
------
R
M
------
M
---
M
-
T
S
---
G
-
Q
-
A
V
K
Y
N
G
-
A
-------------
I
D
C
L
K
K
I
V
A
S
E
G
V
-
G
S
L
F
K
G
C
G
--------
A
N
I
L
R
S
---------
V
A
G
A
G
V
I
S
M
Y
D
Q
L
-
Q
M
I
L
F
G
K
K
---------------------
22
Fugue
65.40
17%
-105
- C1 -
4WID
1
?
A:
[10-362]
-----------------------------KDMAL
Q
H
A
V
D
L
L
E
K
M
L
A
D
E
E
KLTEFNLGDPLFESAND
D
-----
P
I
K
T
L
E
E
I
I
---
Q
E
G
D
D
V
V
G
A
H
Q
--
L
V
V
T
Q
I
K
L
R
V
Q
R
N
R
---------------
R
L
-----
A
D
E
--
I
I
R
E
Q
L
T
D
------
I
R
K
V
F
--
S
D
--------
K
F
E
K
----
L
E
--
Q
G
I
------
Q
------
N
-------
S
Y
---------
L
L
-
L
D
K
L
K
T
PFQDMR
C
L
-
F
E
V
A
N
E
-------
Q
F
N
D
T
P
V
P
-----
P
Q
Y
K
E
F
M
V
C
L
K
Q
I
V
Q
Y
----------
A
V
N
S
-
S
S
L
E
K
F
V
M
L
I
T
K
K
---------------
D
D
-----
I
K
--
D
R
----
V
T
Y
----
T
C
M
K
Y
-
L
L
-----
M
A
--
M
Q
G
T
--
G
G
P
K
A
I
N
N
E
E
----------------
H
------
A
K
L
F
----
F
Q
L
-
S
---
N
--------
Y
D
D
L
T
D
A
N
H
D
G
L
-
E
-
L
I
K
K
L
D
K
E
---
Q
-
K
E
V
A
F
H
V
-
N
---
N
F
T
H
L
V
T
T
L
G
M
A
L
Y
K
E
G
---
H
Q
K
N
D
E
A
M
L
G
M
----------------------------------
H
T
P
I
-----
T
M
--------
L
S
--
D
---
Q
V
R
V
L
-
I
L
-----
Y
L
---------
I
--
D
E
-
I
----
V
H
A
I
H
T
N
----
S
N
Q
S
N
--
D
------
E
L
I
D
G
L
K
P
K
---
V
-
R
I
V
-
I
N
-
E
-
F
H
A
T
L
M
-
M
-------------
G
I
D
K
M
K
F
Y
-------------
S
--------
L
N
E
L
R
E
---------
I
V
N
D
K
I
-------------------------------------
23
Fugue
62.43
15%
-73
- C3 -
3PVT
2
PAAA_ECOLI
A:
[1-304]
-----------------------------MRS
T
Q
E
E
R
F
E
Q
R
I
A
Q
E
T
A
I
------------------
E
-----
P
Q
D
W
M
P
--
D
---
A
Y
R
K
T
L
I
R
Q
I
G
--
Q
H
A
----------
H
---------------
S
E
-----
I
V
G
--
M
L
P
E
G
N
W
I
------
T
R
A
P
T
--
L
R
--------
R
K
A
I
----
L
L
--
A
K
V
------
Q
------
D
-------
E
A
---------
G
H
G
L
-----------
Y
L
-
Y
S
A
A
E
T
-------
L
G
C
---------------
A
R
E
D
I
Y
Q
K
M
L
D
----------
G
R
M
K
Y
S
S
I
F
N
Y
P
T
L
S
W
A
D
---------------
I
G
-----
V
I
--
G
W
----
L
-
V
----
D
G
A
A
I
-
V
N
-----
Q
V
A
L
C
R
T
S
--
Y
G
P
Y
A
R
A
-
M
V
----------------
K
------
I
C
K
E
----
E
S
F
-
H
---
Q
--------
R
Q
G
F
E
A
C
M
A
L
A
Q
G
S
-
E
A
Q
K
Q
M
L
Q
---
D
-
A
I
N
R
F
W
W
-
P
---
A
L
M
M
F
G
P
N
D
D
N
S
---------------
P
N
S
A
R
S
L
-----------------------
T
W
K
-
I
K
R
-
F
T
N
D
-----
E
L
--------
R
Q
--
R
---
F
V
D
N
T
-
V
P
-----
Q
V
---------
E
M
L
G
M
-
T
----
V
P
D
P
D
L
H
----
F
D
T
E
S
--
G
------
H
Y
------
R
---
F
-
G
E
I
D
W
Q
-
E
-
F
N
E
V
I
N
-----------------------
G
R
G
I
C
N
Q
E
R
L
D
A
K
R
--------
K
A
W
E
E
G
---------
T
W
V
R
E
A
A
L
A
H
A
Q
K
------------------------------
26
Fugue
59.14
14%
-87
* C4 *
4US5
1
?
A:
[4-338]
--------------------------------H
V
K
L
S
V
V
E
Q
A
P
V
V
E
G
L
------------------
T
-----
P
A
H
S
L
Q
H
S
I
---
E
L
A
R
L
A
D
R
L
G
Y
E
R
F
W
V
----------
A
---------------
E
H
H
AEIF
N
A
V
--
P
A
P
E
I
L
I
A
------
R
I
A
A
E
--
T
S
--------
G
I
R
V
G
S
GG
V
L
--
L
S
L
------
Y
------
S
-------
P
L
---------
K
V
-
A
-----------
E
V
-
F
R
T
L
H
A
-------
L
Y
P
D
R
I
D
L
-----
G
I
G
R
A
N
R
V
K
L
P
V
F
A
A
L
R
---------
D
D
S
S
D
D
L
W
R
R
L
E
Q
L
R
A
Y
L
---------------
D
P
-----
D
S
--
G
L
----
P
-
F
----
T
V
S
P
R
M
P
G
-----
G
P
--
A
L
W
L
--
L
G
A
---
S
-
V
S
----------------
S
------
A
E
A
A
----
A
R
L
-------------------
G
L
P
Y
A
Y
A
-
H
F
I
T
P
Q
F
T
R
E
---
A
M
D
T
Y
R
A
A
F
V
P
---
G
P
D
T
P
S
P
R
P
I
L
S
V
V
V
C
C
A
ET
D
A
E
A
Q
R
V
Y
A
T
H
R
L
F
-----------------------
H
R
R
M
S
Q
G
-
D
V
R
L
-----
L
P
--------
P
A
--
D
---
L
A
V
A
E
M
D
K
-----
P
G
---------
P
--
D
P
-
L
----
A
E
E
---------
S
F
E
W
--
P
------
R
Y
------
V
---
V
-
G
S
P
-
D
R
-
V
-
R
D
Q
L
T
K
M
A
-------------
D
A
T
----------------
G
A
E
--------
E
L
G
V
V
S
M--------
I
H
D
Q
R
D
R
L
R
S
Y
R
L
-
L
A
E
A
F
E
L
T
PR-------------------
8
HHSearch
57.69
26%
-67
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-300]
---------------------------------------------------------------------------------------------------
T
----------
V
---------------
K
F
-----
L
G
A
--
G
T
A
A
C
I
A
D
------
L
I
T
F
P
--
L
D
--------
T
A
K
V
----
R
L
--
Q
I
Q
------
G
------
E
-------
S
Q
G
L
V
R
T
A
ASA
Q
Y
-
R
-----------
G
V
-
L
G
T
I
L
T
-------
M
V
R
T
E
G
P
R
-----
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
----------
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
T
K
G
---------------
S
E
-----
H
A
--
G
I
----
G
-
S
----
R
L
L
A
G
-
S
T
-----
T
G
--
A
L
A
V
--
A
V
A
Q
P
T
D
-
V
V
----------------
K
------
V
R
F
Q
----
A
Q
A
-
R
---
A
GG------
G
R
R
Y
Q
S
T
V
E
A
Y
K
-
T
-
I
-
A
R
E
E
G
I
---
R
-
G
L
W
K
G
T
S
-
P
---
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
Y
D
---
L
I
K
D
T
L
L
K
A
N
L
M
T
---------------------------------------------------
D
D
--
L
---
P
C
H
F
T
-
S
A
-----
F
G
---------
A
--
G
F
-
C
----
T
T
V
I
A
S
P
----
V
D
V
V
K
--
T
------
R
Y
------
M
---
N
-
S
A
L
-
G
------
Q
Y
H
S
-
A
-------------
G
H
C
A
L
T
M
L
R
K
E
G
-
P
R
A
F
Y
K
G
F
M
--------
P
S
F
L
R
L
---------
G
S
W
N
V
V
M
F
V
T
Y
E
Q
-
L
K
R
A
L
M
A
A
---------------------
6
PsiBlast_PDB
57.48
26%
-70
- C5 -
2LCK
-
UCP2_MOUSE
A:
[17-296]
-------------------------------------------------------------------------------------------------------------------------------
F
-----
L
G
A
--
G
T
A
A
C
I
A
D
------
L
I
T
F
P
--
L
D
--------
T
A
K
V
----
R
L
--
Q
I
Q
------
G
------
E
-------
S
Q
G
L
V
R
T
A
ASA
Q
Y
-
R
-----------
G
V
-
L
G
T
I
L
T
-------
M
V
R
T
E
G
P
R
-----
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
----------
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
T
K
G
---------------
S
E
-----
H
A
--
G
I
----
G
-
S
----
R
L
L
A
G
-
S
T
-----
T
G
--
A
L
A
V
--
A
V
A
Q
P
T
D
-
V
V
----------------
K
------
V
R
F
Q
----
A
Q
A
-
R
AG-
G
--------
G
R
R
Y
Q
S
T
V
E
A
Y
K
-
T
-
I
-
A
R
E
E
G
I
---
R
-
G
L
W
K
G
T
S
-
P
---
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
Y
D
---
L
I
K
D
-------
T
L
L
-------------------------------
K
A
N
L
-----
M
T
--------
D
D
--
L
---
P
C
H
F
T
-
S
A
-----
F
G
---------
A
--
G
F
-
C
----
T
T
V
I
A
S
P
----
V
D
V
V
K
--
T
------
R
Y
----------
M
-
N
S
A
-
L
G
-
Q
-
Y
H
S
A
G
H
-
C
-------------
A
L
T
M
L
R
K
E
G
P
----
R
A
F
Y
K
G
F
M
--------
P
S
F
L
R
L
---------
G
S
W
N
V
V
M
F
V
T
Y
E
Q
-
L
K
R
A
L
M
A
A
---------------------
11
HHSearch
56.67
24%
-73
- C5 -
1OKC
8
ADT1_BOVIN
A:
[5-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
S
F
----
L
-
K
----
D
F
L
A
G
-
G
V
-----
A
A
--
A
I
S
K
--
T
A
V
A
P
I
E
-
R
V
----------------
K
------
L
L
L
Q
----
V
Q
H
-
A
---
S
KQISA---
E
K
Q
Y
K
G
I
I
D
C
V
V
-
R
-
I
-
P
K
E
Q
G
F
---
L
-
S
F
W
R
G
N
L
-
A
---
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
---
K
Y
K
Q
I
F
L
G
G
V
D
R
H
K
----------------------------------
Q
-----
F
W
--------
R
Y
--
F
---
A
G
N
L
A
-
S
G
-----
G
A
---------
A
--
G
A
-
T
----
S
L
C
F
V
Y
P
----
L
D
F
A
R
--
T
------
R
L
------
A
---
A
-
D
V
G
-
K
G
-
A
A
Q
R
E
F
T
G
-
L
-------------
G
N
C
I
T
K
I
F
K
S
D
G
-
L
R
G
L
Y
Q
G
F
N
--------
V
S
V
Q
G
I
---------
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
-
A
K
G
M
L
P
D
P
---------------------
19
Fugue
56.65
18%
-81
* C3 *
4PXG
-
T2S3_STAAU
A:
[26-509]
-----------T
K
Q
A
V
H
N
R
A
K
E
A
VGKS
V
L
E
L
N
GGE
S
I
K
S
S
V
G
D
A
F
E
N
W
F
G----------------
V
-----
A
L
K
A
T
P
F
K
K
---
L
K
N
G
K
Y
S
S
K
E
R
--
L
V
L
----------
N
IIN
Y
E
K
V
A
N
ENFETS
S
F
-----
L
S
K
N
N
T
I
E
L
A
F
Y
E
Y
I
K
GTP
S
D
N
W
I
--
I
K
--------
E
A
V
L
----
Y
E
M-
H
K
N
------
P
------
I
-------
D
Y
---------
E
I
-
I
-----------
K
Q
D
W
E
I
I
N
Q
-------
Y
I
N
E
G
K
A
H
-----
E
L
S
E
G
L
T
S
Y
L
A
P
C
T
K
G
----------
A
N
A
S
S
L
R
N
Q
P
Y
S
D
I
K
A
K
Q
---------------
R
A
-----
F
S
L
K
S
G
----
Y
M
T
----
S
I
L
R
K
-
Y
V
-----
L
G
--
D
E
K
I
D
S
I
V
K
D
P
F
E
-
I
K
----------------
E
KS
I
E
D
I
V
F
E
K
----
F
Q
P
-
Y
---
I
--------
N
W
S
I
D
K
L
C
E
H
F
S
-
I
-
N
K
G
E
K
G
L
N
---
Y
-
R
I
A
S
A
I
L
-
N
LK
G
K
T
T
K
S
K
P
F
P
E
V
E
E
F
E
K
S
S
I
-
V
V
K
T
V
H
F
N
K
K
N
V
N
K
E
S
M
S
F
G
AFK
F
E
E
L
A
N
EEWEDSE-
G
Y
P
-
S
A
Q
-
W
R
N
F
-----
L
L
E
TRFL
F
F
V
V
K
--
E
D
ED
G
V
D
I
F
-
K
G
-----
I
K
---------
F
--
F
S
M
P
----
E
E
D
I
N
G
P
V
K
R
M
W
D
D
T
V
--
K
------
K
L
------
K
---
E
-
G
V
T
-
L
E
-
A
-
V
P
D
K
S
T
-
K
DG
W
R
I
K
N
NFVDKS
D
D
L
I
C
H
V
R
P
H
T
N
N
R
D
--
Y
R
G
G
S
N
A
D
K
L
PKK
I
N
W
I
N
R
---------
P
D
S
D
D
Y
---
S
D
E
W
M
T
K
Q
S
F
W
I
N
N
D
Y
I
K
K
Q
V
EDLL---------
21
Fugue
56.22
15%
-79
- C2 -
4K6L
2
?
G:
[1-224]
----------------------------------------
V
D
F
V
Y
R
V
D
------------------
S
-----
T
P
P
D
V
I
F
R
D
---
G
F
S
L
L
G
Y
N
R
N
-----
F
----------
Q
---------------
Q
F
-----
I
S
G
--
R
S
C
S
G
G
S
S
DSRYI-
A
T
T
S
S
--
V
N
--------
Q
T
Y
A
----
I
A
--
R
A
Y
------
Y
------
S
-------
R
S
---------
T
F
-
K
-----------
G
N
-
L
Y
R
Y
Q
I
-------
R
A
D
N
N
---------
F
Y
S
----------
L
L
----------
P
S
I
T
Y
L
E
T
Q
--------------------------------
G
--
G
H
----
F
-
N
----
A
Y
E
K
T
-
M
M
-----
R
L
--
Q
R
E
Y
--
V
S
T
L
S
I
L
-
P
E
----------------
N
------
I
Q
K
A
----
V
A
L
-
V
---
Y
--------
D
-
S
A
T
G
L
V
K
D
G
V
-
S
-
T
M
N
----------------------------------------------------
A
S
Y
L
-----------------------
G
L
S
-
T
T
S
-
N
P
G
V
-----
I
P
--------
F
-----------------------------------------------
L
P
----
E
P
Q
T
Y
--
T
------
Q
Q
------
R
---
I
-
D
A
F
-
G
P
-
L
-
I
S
S
C
F
S
-
I
-------------
G
S
V
C
---
H
S
H
R
G
Q
R
A
D
V
Y
---
N
--------
M
S
F
Y
D
A
---------
R
P
V
I
E
L
I
L
S
K
---------------------------------
27
Fugue
56.20
16%
-73
- C4 -
4NNB
-
?
A:
[4-527]
T
S
L
Y
I
T
A
A
P
I
GA
V
P
K
F
L
DPFEATFIP
S
F
L
L
E
GFFD
A
D
R
C
A
S
I
A
A
D
L
K
T
------------------
D
G
W
E
V
V
P
A
G
G
R
L
L
Q
V
---
G
H
A
Q
P
I
A
H
F
P
K
--
P
W
L
----------
A
---------------
A
L
-----
S
N
K
--
L
A
R
R
I
V
L
Q
------
L
T
T
Y
G
W
I
V
S
--------
E
Q
G
D
----
L
L
W
E
H
E
R
------
Q
------
H
-------
H
Y
---------
L
P
-
P
-----------
A
L
-
I
E
A
I
E
K
E
S
P
A
L
L
K
N
M
E
E
A
G
W
I
-----
A
C
A
A
G
Y
W
Q
A
G
K
A
R
S
P
Y
LPIT
P
E
A
I
T
E
E
T
I
R
S
M
R
A
G
A
A
V
V
H
L
H
T
R
D
LSD
R
R
R
I
E
I
P
GL
G
V
V
T
-----
V
G
--
S
Q
----
R
-
N
----
Q
I
V
L
D
-
D
Y
-----
D
A
--
I
V
P
M
--
V
K
K
R
E
P
A
-
A
I
L
N
L
S
TSVRGDRHGARS
K
------
L
R
R
A
HLKF
Y
D
D
-
V
---
G
--------
S
A
P
E
V
A
S
L
S
P
A
A
-
V
-
V
F
Q
G
G
G
G
Y
D
NA
P
-
D
F
L
D
A
Q
F
-
D
---
H
F
E
R
V
G
T
R
P
E
V
E
V
F
N
H
A
---
I
V
D
N
A
T
S
L
Y
R
D
R
L
L
R
T
GKP
V
L
F
M
L
VAG
V
D
Q
Y
R
R
DPIT
G
E
V
-
E
D
D
-
S
L
I
A
-----
R
V
--------
V
R
--
E
---
E
I
S
S
L
-
L
A
D
ES
A
D
S
H
---------
R
--
R
A
-
V
----
E
L
A
I
G
Q
L
----
R
P
V
V
E
--
R
L
R
A
S
F
P
V
S
------
K
---
I
-
S
I
L
-
L
P
-
G
-
P
M
Q
N
L
L
-
V
-------------
D
V
A
L
G
L
--
G
L
D
G
I
R
V
G
L
E
D
G
L
T
--------
V
N
D
A
R
V
---------
P
G
G
V
R
K
A
R
G
T
W
E
Q
-
V
S
L
V
R
E
E
L
L
G
R
G
A
T
I
L
T
A
A
Q
V
R
D
M
F
GLGI
25
Fugue
55.88
16%
-69
- C4 -
4NZR
1
Y281_MYCGE
M:
[26-416]
---------------NDGSYQSEIDLSGGANFREK
F
R
N
F
A
N
E
L
S
E
A
I
T
------------------
N
-----
S
P
K
G
L
D
R
P
V
PKT
E
I
S
G
L
I
K
T
G
D
N
--
F
I
T
----------
P
---------------
S
F
-----
K
A
G
--
Y
Y
D
H
V
A
S
D
------
G
S
L
L
S
--
Y
Y
QSTEYFNN
R
V
L
M
P---
I
L
--
Q
T
T
------
N
GT----
L
-------
M
A
---------
N
N
-
R
-----------
G
Y
-
D
D
V
F
R
Q
-------
V
P
S
F
S
G
W
S
NTKAT
T
V
S
T
S
N
N
L
T
Y
D
K
W
T
Y
F
----------
A
A
K
G
S
P
L
Y
D
S
Y
P
N
H
F
F
E
D
----------------------------------
V
----
K
T
L
A
I
-
D
A
-----
K
D
--
I
S
A
L
--
K
T
T
I
D
S
E
-
K
P
----------------
T
------
Y
L
I
I
----
R
G
L
-
S
---
G
--------
N
G
S
Q
L
N
E
L
Q
L
P
E
-
S
-
V
--
K
K
V
S
L
---
Y
-
G
D
Y
T
G
V
N
-
V
---
A
K
Q
I
F
A
N
V
V
E
L
E
F
Y
S
T
S
---
K
A
N
S
F
G
F
N
--
P
L
V
L
-----------------------
G
S
K
-
T
N
V
-
I
Y
D
L
-----
F
A
--------
S
K
PF
T
---
H
I
D
L
T
-
Q
V
-----
T
L
QNSDNSAID
A
--
N
K
-
L
----
K
Q
A
V
G
D
I
----
Y
N
Y
R
R
FE
R
------
Q
F
------
Q
GYF
A
-
G
G
Y
-
I
D
-
K
-
Y
L
V
K
N
V
-
N
TNKDSDD------
D
L
V
Y
R
S
L
K
E
L
N
L
H
L
E
E
A
Y
R
E
G
D
--------
N
T
Y
Y
R
V
NENYYPGAS
I
Y
E
N
E
R
A
S
R
D
S
E
F
-
Q
N
E
I
L
K
R
----------------------
10
HHSearch
39.66
23%
-59
- C5 -
2LCK
-
UCP2_MOUSE
A:
[15-205]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----
K
F
L
G
A
-
G
T
-----
A
A
--
C
I
A
D
--
L
I
T
F
P
L
D
-
T
A
----------------
K
------
V
R
L
Q
----
I
Q
G
-
E
---
S
QG
L
V
R
T
A
A
S
A
Q
Y
R
G
V
L
G
T
I
L
-
T
-
M
-
V
R
T
E
G
P
---
R
-
S
L
Y
N
G
L
V
-
A
---
G
L
Q
R
Q
M
S
F
A
S
V
R
I
G
L
Y
D
---
S
V
K
Q
F
Y
T
K
G
S
E
--------------------------------------------
H
--------
A
G
--
I
---
G
S
R
L
L
-
A
G
-----
S
T
---------
T
--
G
A
-
L
----
A
V
A
V
A
Q
P
----
T
D
V
V
K
--
V
------
R
F
------
Q
---
A
-
Q
A
R
-
A
G
-
G
-
G
R
R
Y
Q
S
-
T
-------------
V
E
A
Y
K
T
I
A
R
E
E
G
-
I
R
G
L
W
K
G
T
S
--------
P
N
V
A
R
N
---------
A
I
V
N
C
A
E
L
V
T
Y
D
L
-
I
K
D
T
L
L
K
A
---------------------
7
PsiBlast_PDB
28.70
30%
-4
- C5 -
3PMI
1
MUM1_HUMAN
A:
[54-125]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
K
---
S
L
K
H
F
D
C
K
E
K
Q
T
L
L
-----------------------
N
Q
A
-
R
E
D
F
N
Q
D
I
G
W
C
V
S
L
I
--------
T
D
--
Y
---
R
V
R
L
G
-
C
G
-----
S
F
---------
A
--
G
S
-
F
L
E
Y
Y
A
A
D
I
S
Y
P
----
V
R
K
S
I
--
Q
------
Q
D
------
V
---
L
-----------------------------------------------------------------------------------------------------------------------
20
Fugue
23.93
29%
242
- C5 -
4UI9
-
?
U:
[1-24]
--------------------------------------
M
S
R
R
P
C
S
C
A
L
------------------
R
-----
P
P
A
A
A
A
A
A
A
---
A
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------