@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GLPT_HUMAN: (2015-12-08 )
MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEADVRFSSQNRKSGSAAPHQLPDNETDCGWAPFDKNNYQQLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKNKPLDPEMQCLLLSDGKGSIHPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSGWSNVFYMLMFADACALLFLIRLIHKELSCPGSATGDQVPFKEQ
Atome Classification :
(20 SA)
---.........10.....---...20.....-...30........40.....-------------------...50........60........70........80........90........100.......110.......120.......130.---......140-.......----..150..-.....160-.......170----.......180.......190...-....200..---.....210..-.---------------------------...--.220.......230.......240.......250.......260........270.......280.......290.......300........310.......320.......330.......340.......350.....-.---.360.......370.......380.......390-..--...----....400.--......410.......420.......430.....---..440.......450.......460.......470....-...480......-.490.......500.......510.......520.......530.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MARLPA
G
I
R
F
I
I
SFSR---
D
Q
W
Y
R
A
F
I
F
I
-
L
T
F
L
L
Y
A
S
F
HLSRK
P
I
S
I
V
K
-------------------
G
E
L
H
K
Y
C
TAWDEA
D
V
R
FSSQNRKSGSAAPHQLPDNETDCGWAPFDKN
N
Y
Q
Q
L
L
G
A
L
D
Y
S
F
L
C
A
Y
A
V
G
M
Y
L
S
G
I
IGERL
P
I
R
Y
Y
L
T
F
G
---
M
LA
S
G
A
F
---
T
A
L
F
G
L
G
----
Y
F
Y
N
I
H
S
-
F
G
F
Y
V
V
T
Q
-
V
I
N
G
L
V
QTTG----
W
P
S
V
V
T
C
L
G
N
W
FGKGR
R
G
L
I
M
G
V-WNSHT
S
V
G
N
---
I
L
G
S
L
I
A
G
Y
W
-
V
---------------------------
S
T
C--WG
L
S
F
VV
P
G
A
I
V
A
A
M
G
I
V
C
F
L
F
L
IEHPNDVRCS
S
T
L
V
THSKG-YENG
T
N
R
L
R
L
Q
K
Q
I
L
K
SEKNKPLDPE
M
Q
C
L
L
LSDGKGSIH-P
N
H
V
V
I
L
PGDGGS
G
T
A
A
I
S
F
T
GALKIP
G
V
I
E
F
S
L
C
L
L
F
A
K
L
V
S
Y
T
F
L
F
W
L
P
L
Y
ITNV-D---HLDAKKAGE
L
S
T
L
F
D
V
G
G
I
F
G
G
I
L
A
G
V
I
S
D
R
L
---
E
K
--
R
A
S
----TC
G
L
M
L
L
L--AA
P
T
L
Y
I
F
S
T
V
S
KM
G
L
E
A
T
I
A
M
L
L
L
S
G
A
LVSG
P
Y
---
T
L
I
T
T
A
VSADLGTHKSLKGN
A
H
A
L
S
T
V
T
A
I
IDGTG
S
V
G
A
-
A
L
G
P
L
L
A
G
L
LSP-SG
W
S
N
V
F
Y
M
L
M
F
A
D
A
C
A
L
L
F
L
I
R
L
I
H
K
E
LSCPGSATGDQVPFKEQ
18
Fugue
91.79
21%
-113
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-FK
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
---
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
-------------------
P
Y
L
V
----------------------------------------
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
---
M
L
F
M
G
F
V
----
P
W
A
T
-
S
S
-
I
A
V
M
F
V
L
L
-
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
---
G
I
P
P
L
L
F
L
L
G
-
M
---------------------------
A
W
F
ND
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
-----
L
P
P
I
E
E
-
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
--------------------------------------------------
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
---
F
R
GN
R
G
A
----
T
G
V
F
F
M
T
L
--
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
---
M
L
I
G
L
H
A
L
E
L
A
P
--
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
-
I
V
G
Y
T
V
D
----
F
-
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----
8
HHSearch
87.67
19%
-123
- C2 -
1PW4
-
GLPT_ECOLI
A:
[6-448]
-----
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
-------------------
P
Y
L
V
-
E
-----------------------------------
Q
G
F
S
R
----
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
---
M
L
F
M
G
F
V
----
P
W
A
-
T
S
S
-
I
A
V
M
F
V
L
L
-
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
---
G
I
P
P
L
L
F
L
L
G
M
A
W--------------------------
F
N
D
--
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------------------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
---
F
R
--
G
N
R
----
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
---
M
L
I
G
L
H
A
-
L
E
L
A
-
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
------
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----
1
PsiBlast_PDB
76.39
20%
-118
- C2 -
1PW4
-
GLPT_ECOLI
A:
[75-438]
--------------------------------------------------------------------------------------------------------------------------------------
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
---
M
L
F
M
G
F
-----
V
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
-
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
GI
P
P
L
L
F
L
L
G
M
A
W
-
F
---------------------------
N
D
---
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
--
C
G
L
P
P
I
E
E
Y
K
N
D-------------
T
A
K
Q
I
F
-------
M
Q
Y
V
L
----------
P
N
K
L
L
W
Y
------------------------
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
FRG
N
R
--
G
A
T
----
G
V
F
F
M
T
L
V
--
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
-
G
F
L
I
Y
G
P
V
---
M
L
I
G
L
H
-
A
L
E
L
A
P
K
K
A
-
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
-
I
V
G
Y
T
V
D
F
F
-----
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----
19
Fugue
63.30
10%
-104
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
MYY
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
---
F
F
I
M
G
A
Y
F
P
F
-
F
P
I
W
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
-------------------
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
------------------------------
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
L
V
G
---
S
I
V
G
G
I
Y
---
L
G
------------
F
C
F
N
-
A
G
A
P
A
V
E
A
-
F
I
E
K
V
S
R
R
S
N
----
F
E
------------------
F
G
R
-
A
R
M
F
G
C
V
G
W
---
A
L
G
A
S
I
V
G
I
M
-
F
---------------------------
T
I
N
--
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
--------------------------------------------------------
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
---
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
---
N
R
--
I
--------
G
G
K
N
A
L
--
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
---
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
---
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
-
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--
24
Fugue
60.28
16%
-48
- C2 -
3J4Q
-
KAP2_MOUSE
B:
[9-394]
----
G
L
T
E
L
L
Q
G
Y
T
V
E
V
L
R
---
Q
Q
P
P
D
L
V
D
F
A
-
V
E
Y
F
T
R
L
R
E
A
R
R
Q
E
S
D
T
F
I
V
S
P
T
T
F
H
T
Q
E
S
S
A
V
P
V
I
E
E
D
G
E
S
D
S
D
S
E
D
A
D
L
E
V
P
V
P
S
K
F
T
R
R
V
S
V
C
A
E
T
F
N
P
D
E
E
E
E
D
V
V
H
P
K
T
D
E
Q
R
C
R
L
Q
E
A
C
K
D
I
L
L
F
K
N
L
D
Q
E
Q
L
S
Q
V
L
D
A
M
F
E
K
I
V
K
T
D
E
H
---
V
I
D
Q
G
D
--------------------
D
G
-
D
N
F
Y
V
I
E
R
G
T
Y
D
I
L
V
T
K
D
N
----
Q
T
R
S
V
G
Q
Y
D
N
R
G
S
F
G
E
L
A
L
M
Y
N
T
-
P
R
A
A
T
I
I
A
T
---
S
E
-------------------------------------
G
S
L
--
W
G
L
D
--------------------
R
V
T
F
R
R
I
I
V
K
N
N
A
K
K
R
K
M
-
F
E
S
F
I
E
S
V
P
L
F
K
S
L
E
M
S
E
R
M
K
I
V
D
V
I
--------
G
E
K
I
Y
K
-
D
G
E
R
I
I
A
Q
G
E
K
A
D
-------------------------------------
S
F
Y
I
I
E
S
-
G
---
E
V
S
I
L
I
R
S
K
T
K
S
N
K
N
G
G
N
-------
Q
E
V
E
I
A
H
---
C
H
--
K
G
Q
----
Y
F
G
E
L
A
L
V
---------------------------------------------------
T
N
K
P
R
A
A
S
A
Y
A
V
G
D
V
K
C
L
V
M
D
V
Q
A
F
E
R
-
L
L
G
P
C
M
D
I
M
K
R
N
-
I
S
H
Y
E
E
Q
L
V
K
M
F
G
S
N
------------------------------
12
HHSearch
58.33
13%
-94
- C2 -
2CFQ
-
LACY_ECOLI
A:
[39-392]
------------------------------------------------------------------------------------------------------------------
H
I
S
K
----
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
---
F
F
I
F
I
F
---------
G
P
L
L
Q
Y
N
I
L
V
G
S
-
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
--
R
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
---
A
L
G
A
S
I
V
G
I
M
-
F
---------------------------
T
I
N
--
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
-
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
-
A
V
-------------------------
G
A
-
N
-
H
------------
S
---------------
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
---
G
G
--
K
N
A
----
L
L
L
A
G
T
I
M
--
S
V
R
I
I
G
S
-
S
F
A
-
T
-
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
---
V
G
C
F
K
Y
I
-
T
S
Q
F
-
E
V
R
F
S
A
T
I
Y
L
V
C
F
-----
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---
10
HHSearch
56.26
17%
-77
- C2 -
2GFP
-
EMRD_ECOLI
A:
[38-359]
-----------------------------------------------------------------------------------------------------------------
L
N
V
R
E
----
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
---
T
L
V
A
V
T
---------
T
S
S
-
L
T
V
L
I
A
A
S
-
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
---
L
L
A
P
L
I
G
G
L
L
D
T
---------------------------
M
W
N
--
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
-----
P
R
--
T
----------------------
R
L
-
L
----------------------------------
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
---
S
T
--
L
M
W
----
Q
S
V
I
C
C
L
L
--
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
---
P
L
A
T
S
G
A
-
M
E
P
F
-
P
-
F
L
A
G
T
A
G
A
L
V
G
------
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
-
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------------
23
Fugue
55.44
18%
-89
- C1 -
3J6V
-
RT09_BOVIN
I:
[68-396]
-----------------------------------------------------------------------------------
S
Y
T
V
D
F
I
K
K
Q
I
E
E
F
N
I
G
K
R
H
L
A
N
M
M
G
E
-
D
P
E
T
F
T
Q
E
D
V
D
R
A
I
T
Y
L
F
P
S
G
L
F
E
K
R
A
R
P
I
M
K
H
-
P
E
E
I
F
P
K
Q
R
A
V
Q
W
G
---
E
-
D
G
R
P
F
---
H
F
L
F
Y
T
G
KQSY
Y
S
L
M
H
E
A
-
Y
G
K
V
L
H
A
E
-
E
R
Q
D
Q
L
R
A
K
G
----
L
F
S
E
--------
K
S
K
S
K
D
L
I
G
S
R
-
W
L
I
K
E
E
L
E
E
---
M
L
V
E
K
L
--------------------------------------------------
S
D
Q
D
Y
A
Q
F
I
R
L
L
E
R
L
S
A
L
P
C
D
A
A
E
E
E
F
V
G
R
-
F
R
R
T
V
T
V
Q
S
K
K
H
L
I
------
E
P
L
Q
Y
D
E
Q
G
M
A
F
S
T
G
Q
G
K
R
K
T
A
N
A
E
A
V
V
Y
G
H
G
---------
S
G
K
I
E
I
N
G
V
D
---
Y
L
L
Y
F
P
V
T
Q
D
R
E
Q
L
M
-
F
P
F
H
F
--
L
-
D
---
R
L
---------
G
K
H
D
V
T
C
T
V
S
G
-------------
G
G
--
R
S
S
----
Q
A
G
A
I
R
L
A
--
M
S
R
A
L
C
S
F
I
T
------
E
D
E
V
E
W
M
R
Q
A
G
L
L
T
T
D
P
----
R
V
R
E
R
K
K
P
G
Q
E
G
A
R
R
K
F
T
W
K
K
R
----------------------------------------------------------------------------
9
HHSearch
54.43
13%
-101
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[22-329]
-------------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
-------------------
P
Q
F
Q
Q
A
-----------------------------------
F
T
L
T
N
----
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
---
A
A
L
F
W
P
A
----
A
E
--
I
M
N
-
Y
T
L
F
L
V
G
L
-
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
---
I
I
A
V
V
F
G
Q
S
L
-
I
LSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
--
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
--
M
L
T
K
F
P
A
L
Q
S
D
N
-
H
-
S
D
-
A
-----------------------
K
Q
-
G
---
S
----------
F
------------------
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
---
A
P
--
H
K
V
----
L
A
A
Y
A
L
I
A
--
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
---
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
-
G
N
I
P
T
A
E
L
I
P
A
L
-
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------
14
HHSearch
54.26
15%
-110
- C2 -
3WDO
-
?
A:
[11-176]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
---
G
R
--
K
P
L
----
I
V
G
G
L
A
V
F
--
A
A
G
S
V
I
A
A
L
-
S
-
D
-
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
I
--
A
---
A
A
V
M
A
L
L
-
S
D
L
T
-
R
E
Q
N
R
T
K
A
M
A
F
I
G
------
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
3
PsiBlast_PDB
48.50
20%
-84
- C2 -
1PV7
1
LACY_ECOLI
A:
[29-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
P
I
W
L
H
D
I
-
N
---
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
---
G
L
--
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
--
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
--------
L
V
G
S
I
V
G
G
I
Y
LGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
----
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
-
I
N
N
Q
F
V
F
W
L
---
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
2
PsiBlast_PDB
48.12
20%
-77
- C2 -
1PV6
-
LACY_ECOLI
A:
[29-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
P
I
W
L
H
D
I
-
N
---
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
---
G
L
--
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
--
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
--------
L
V
G
S
I
V
G
G
I
Y
LGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
----
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
-
I
N
N
Q
F
V
F
W
L
---
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
16
HHSearch
46.97
19%
-89
- C2 -
2GFP
-
EMRD_ECOLI
A:
[26-171]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
P
A
I
A
D
M
A
-
R
D
-
L
---
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
---
G
R
--
R
P
V
----
I
L
V
G
M
S
I
F
--
M
L
A
T
L
V
A
V
T
-
T
-
S
-
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
---
V
M
A
R
T
L
P
-
R
D
L
Y
-
E
R
T
Q
L
R
H
A
N
S
L
L
N
------
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
5
PsiBlast_PDB
46.28
20%
-72
- C2 -
2CFQ
-
LACY_ECOLI
A:
[29-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
P
I
W
L
H
D
I
-
N
---
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
---
G
L
--
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
--
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
--------
L
V
G
S
I
V
G
G
I
Y
LGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
----
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
-
I
N
N
Q
F
V
F
W
L
---
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
4
PsiBlast_PDB
46.19
20%
-83
- C2 -
2CFP
-
LACY_ECOLI
A:
[29-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
P
I
W
L
H
D
I
-
N
---
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
---
G
L
--
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
--
A
P
F
F
I
F
I
F
G
P
L
L
Q
Y
N
I
--------
L
V
G
S
I
V
G
G
I
Y
LGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
----
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
-
I
N
N
Q
F
V
F
W
L
---
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
13
HHSearch
44.03
19%
-63
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[38-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
-
A
-
F
---
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
---
S
Y
--
K
A
G
----
I
I
T
G
L
F
L
Y
--
A
L
G
A
A
L
F
W
P
A
A
E
I
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
---
T
A
A
N
P
F
V
-
T
V
L
G
-
P
E
S
S
G
H
F
R
L
N
L
A
Q
------
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
-
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
15
HHSearch
39.83
14%
-86
- C2 -
2CFQ
-
LACY_ECOLI
A:
[259-393]
--------------------------------------------------------------------------------------------------------------------------
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
---
I
I
G
S
S
F
---------
A
T
S
-
A
L
E
V
V
I
L
K
-
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
---
I
F
M
S
V
L
A
G
N
M
Y
E
---------------------------
S
I
G
--
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
39.69
11%
-120
- C2 -
3WDO
-
?
A:
[41-188]
-----------------------------------------------------------------------------------------------------------------
Q
G
A
S
E
----
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
---
S
V
I
A
A
L
---------
S
D
S
-
I
W
G
I
I
L
G
R
-
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
---
A
I
A
M
V
L
G
P
I
I
T
H
---------------------------
K
L
G
--
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
-
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
-
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
-
W
---
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
---
K
G
--
T
A
M
----
G
V
Y
S
T
S
Q
F
--
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
---
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
-
K
E
V
L
I
A
E
E
E
H
S
A
-
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------
17
HHSearch
38.12
14%
-81
- C2 -
1PW4
-
GLPT_ECOLI
A:
[289-430]
--------------------------------------------------------------------------------------------------------------------------
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
----
P
---
A
G
N
-
P
T
V
D
M
I
C
M
-
I
V
I
G
F
L
I
Y
G
P
----
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
--
V
A
A
S
A
I
V
G
Y
T
V
D
---------------------------
F
F
G
--
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
38.01
32%
-88
- C2 -
4PYP
-
GTR1_HUMAN
A:
[71-138]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
---
G
R
--
R
N
S
----
M
--
L
M
M
N
L
--
L
A
F
V
S
A
V
L
M
G
F
S
K
L
G
--
K
S
F
E
M
L
I
L
-
G
R
F
I
I
G
V
Y
---
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
-
Q
V
F
G
L
D
S
I
M
G
N
K
-
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L