@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR10_HUMAN: (2015-12-08 )
MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS
Atome Classification :
(20 SA)
-.........10........20........30......--------..-40-------.......-------.--------.50-----.....--------....60........70.......-.80--........-----------------.90..------------------.----.---.----.-..100.......110..----.....120.......130.......140.......150.....-...---.160-----------------------..----.......170......-.180..--...-------..---------.190...------------....200.-----------......210.......220-.........-----------230---.-......-.240.......250.......260--.........270.......280.......290.......300.-------......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..-......-460......------.------470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MGHSPP
V
L
P
L
C
A
S
V
S
L
L
GGLTFG
Y
E
L
A
VIS
G
A
L
L
P
L
Q
--------
L
D
-
F
--------
G
L
S
C
L
E
Q
-------
E
--------
F
L
------
V
G
S
L
L
--------
L
G
A
L
L
A
S
L
V
G
G
F
L
I
D
CYGR
K
Q
AI-LG---S
N
L
V
L
L
AG-----------------SL
T
L
G
------------------
L
----
A
---
G
----
S
-
L
A
W
L
V
L
G
R
A
V
V
G
F
A
I
S
L
----
S
S
M
A
C
C
I
Y
V
S
E
LVGPRQR
G
V
L
V
S
L
Y
EAG
I
T
V
G
I
L
L
S
--
Y
A
L
N
Y
-ALA---GT-------------------------PW----G
W
R
H
MFGW
A
T
A
P
A
V
L
Q
-
S
L
-
S
L
L
--
F
LP-------AG---------TDETATH------------K
D
L
IPLQG-----------GEAPKLGPGRP
R
Y
S
F
L
D
---
L
F
R
A
RDNMR-----------GR----T-
T
V
G
L
G
L
-
V
L
F
Q
Q
LTGQP
N
V
L
C
Y
A
S
T
I
F
S
S
----VGFHGG
S
S
A
V
L
A
S
VGL
G
A
V
K
V
A
A
T
L
T
A
M
G
L
V
D
RAGR
R
A
L
L
L
A
G
-------
C
A
L
M
A
L
S
VS
G
I
G
L
V
S
F
A
VPMDSGP
S
C
L
AVPNATGQTGLPGDSGLLQDSSLPPIPRTN
E
D
Q
RE
P
I
L
S
T
A
KKTKPHPRSGDPSAPP
R
L
A
LSSALPGPPLPARG
H
A
L
L
R
W
T
A
L
L
C
L
M
V
F
V
S
A
FSFGF
G
P
V
T
W
L
V
LSEI
Y
P
V
E
IR
G
R
A
F
A
F
C-NS-FN
W
A
A
N
-
L
F
I
S
L
S
F
L
D
------
L
------
I
G
TI
G
L
S
W
T
F
L
L
Y
G
L
T
A
V
L
G
L
G
F
I
Y
L
F
V
PETKG
Q
S
L
A
E
I
D
Q
Q
F
Q
KR
R
F
T
L
S
FGHRQNSTGI
P
Y
S
R
I
E
I
SAAS
20
Fugue
94.42
30%
-127
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
VAPQNLS
E
S
A
A
N
S
L
L
-------
G
--------
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
-
K
I
---
A
A
V
L
F
F
I
S
-----------------
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
R
S
G
D
A
-------------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
ES
P
R
W
L
M
S
R
---------
G
K
Q
E
Q
A
E
------------
G
I
L
R
K
I
M
G
-----------
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
---
G
R
K
T
G
G
R
L
L
-----------
M
F
GVG
V
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
----
L
G
A
-
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
-------------------------------------------------------------------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
-
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
----------------------------
21
Fugue
90.22
33%
-146
- C2 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
-
K
I
---
A
A
V
L
F
F
I
S
-----------------
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
R
SG
D
A
-------------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
---------------
S
P
------------
R
W
L
M
T
L
A
T
-----------
Q
A
V
Q
E
I
K
H
S
L
D
R
L
-----------
L
M
F
G
V
-----------
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
----
L
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------------------------------------------------------------------------
P
G
------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
-
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
------------------------------------
7
PsiBlast_PDB
74.15
27%
-126
- C2 -
4ZW9
4
?
A:
[30-366]
------
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
---------
E
-
F
--------
I
T
K
T
L
T
D
K
GNAPPS
E
--------
V
L
------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
-
L
I
---
V
N
L
L
A
V
T
G
-----------------
G
C
F
M
G
------------------
L
CKV-
A
---
K
----
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
-
I
L
----
G
S
-------------------------
E
E
----
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
-
S
A
-
A
L
P
--
F
C
P
-------
E
S
P
R
F
L
L
INRK
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
------------
E
S
A
R
M
S
Q
E
K
-
Q
V
T
V
L
E
---
L
F
R
V
-
S
S
Y
R
-----------
Q
P
----
I
-
I
I
S
I
V
L
-
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
----
A
G
V
Q
---
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-------
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.10
27%
-124
- C2 -
4ZWB
1
?
A:
[30-366]
------
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
---------
E
-
F
--------
I
T
K
T
L
T
D
K
GNAPPS
E
--------
V
L
------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
-
L
I
---
V
N
L
L
A
V
T
G
-----------------
G
C
F
M
G
------------------
L
CKV-
A
---
K
----
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
-
I
L
----
G
S
-------------------------
E
E
----
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
-
S
A
-
A
L
P
--
F
C
P
-------
E
S
P
R
F
L
L
INRK
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
------------
E
S
A
R
M
S
Q
E
K
-
Q
V
T
V
L
E
---
L
F
R
V
-
S
S
Y
R
-----------
Q
P
----
I
-
I
I
S
I
V
L
-
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
----
A
G
V
Q
---
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-------
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.36
27%
-124
- C2 -
4ZWC
3
?
A:
[30-366]
------
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
---------
E
-
F
--------
I
T
K
T
L
T
D
K
GNAPPS
E
--------
V
L
------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
-
L
I
---
V
N
L
L
A
V
T
G
-----------------
G
C
F
M
G
------------------
L
CKV-
A
---
K
----
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
-
I
L
----
G
S
-------------------------
E
E
----
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
-
S
A
-
A
L
P
--
F
C
P
-------
E
S
P
R
F
L
L
I
NRK
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDVS
Q
D
I
Q
E
M
K
D
------------
E
S
A
R
M
S
Q
E
K
-
Q
V
T
V
L
E
---
L
F
R
V
-
S
S
Y
R
-----------
Q
P
----
I
-
I
I
S
I
V
L
-
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
----
A
G
V
Q
---
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-------
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.09
27%
-119
- C2 -
4PYP
1
GTR1_HUMAN
A:
[19-345]
---------------
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
T
Q
T
W
V
H
R
-
Y
--------
G
E
S
I
L
P
T
-------
T
--------
L
T
T
L
W
S
L
S
V
A
I
F
S
--------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
-
L
M
---
M
N
L
L
A
F
V
S
-----------------
A
V
L
M
G
F
SK---------------
L
----
G
---
K
----
S
-
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
----
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
--
Q
V
F
G
L
D
S
I
M
---
G
N
-------------------------
K
D
----
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
-
C
I
-
V
L
P
--
F
C
P
-------
E
S
P
R
F
L
L
INR-
N
E
E
N
R
A
K
------------
S
V
L
K
K
L
R
G
TADV
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
---
L
F
R
S
-
P
A
Y
R
-----------
Q
P
----
I
-
L
I
A
V
V
L
-
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
----
A
G
V
Q
---
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
-------
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
C
G
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.62
27%
-123
- C2 -
5C65
8
?
A:
[8-344]
------
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
--------
E
F
-
I
--------
Q
K
T
L
T
D
K
GNAPPS-
E
--------
V
L
------
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
-
L
I
---
V
N
L
L
A
V
T
G
-----------------
G
C
F
M
G
------------------
L
C
KV-
A
---
K
----
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
-
I
L
----
G
S
-------------------------
E
E
----
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
-
S
A
-
A
L
P
--
F
C
P
-------
E
S
P
R
F
L
L
INRK
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
------------
E
S
A
R
M
S
Q
E
K
-
Q
V
T
V
L
E
---
L
F
R
V
-
S
S
Y
R
-----------
Q
P
----
I
-
I
I
S
I
V
L
-
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
----
A
-------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-------
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.47
27%
-113
- C2 -
4GC0
4
XYLE_ECOLI
A:
[16-360]
--------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDN
T
V
P
V
Y
------------------
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
---
R
S
GD
A
----------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
S
---------
P
R
W
L
M
S
R
------------
G
K
Q
E
Q
A
E
G
-----------
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
---
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
GV
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
----
L
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.40
27%
-110
- C2 -
4JA3
-
XYLE_ECOLI
A:
[16-360]
--------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGF
T
S
I
N
P
D
N
T
V
P
V
Y
------------------
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
---
R
S
GD
A
----------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
S
---------
P
R
W
L
M
S
R
------------
G
K
Q
E
Q
A
E
G
-----------
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
---
I
K
H
S
L
D
H
G
R
-----------
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.16
27%
-110
- C2 -
4GBY
4
XYLE_ECOLI
A:
[16-360]
--------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDN
T
V
P
V
Y
------------------
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
---
R
S
GD
A
----------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
S
---------
P
R
W
L
M
S
R
------------
G
K
Q
E
Q
A
E
G
-----------
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
---
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
GV
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
----
L
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.13
27%
-112
- C2 -
4GBZ
4
XYLE_ECOLI
A:
[16-360]
--------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGFTSINPDN
T
V
P
V
Y
------------------
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
---
R
S
GD
A
----------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
S
---------
P
R
W
L
M
S
R
------------
G
K
Q
E
Q
A
E
G
-----------
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
---
I
K
H
S
L
D
H
G
R
K
T
GGRLLMFGV
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
----
L
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.41
27%
-116
- C2 -
4JA4
-
XYLE_ECOLI
A:
[16-360]
--------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
--------
T
V
-
F
--------
V
A
P
Q
N
L
S
-------
E
S
A
A
N
S
L
L
G
F
C
------
V
A
S
A
L
--------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGF
T
S
I
N
P
D
N
T
V
P
V
Y
------------------
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
--
Y
C
V
N
Y
-
F
I
A
---
R
S
GD
A
----------------------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
-
L
M
-
L
L
Y
--
T
V
P
-------
E
S
---------
P
R
W
L
M
----------------
Q
E
Q
A
E
G
-----------
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
---
I
K
H
S
L
D
H
G
-MFG
V
-------
G
V
----
I
-
V
I
G
V
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
----------------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-------
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------------------------------------------------------------------------------------------
22
Fugue
63.96
12%
-117
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
--------------------
H
I
S
K
S
D
T
-------
G
--------
I
I
------
F
A
A
I
S
--------
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
-
L
W
---
I
I
T
G
M
L
V
M
-----------------
F
A
P
F
F
------------------
I
F
I
F
G
P
---
L
----
L
-
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
----
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
--
L
G
A
S
I
-
V
G
I
---
M
F
-------------------------
T
I
----
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
-
A
V
-
L
L
F
--
F
A
K
-------
T
D
---------
A
P
S
S
A
T
V
------------
A
-------------------
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
---
E
L
F
R
Q
P
K
L
W
-----------
F
L
----
S
-
L
Y
V
I
G
V
-
S
C
T
Y
D
V
F
-
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
----
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
-
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
-------
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
------------------------------------------------------------------------------------------
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
------
M
------
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------
29
HHSearch
63.33
13%
-128
- C2 -
1PW4
-
GLPT_ECOLI
A:
[24-447]
-----
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
---------
E
-
Q
--------
G
F
S
R
G
D
L
-------
G
--------
F
A
------
L
S
G
I
S
--------
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
-
P
A
---
G
L
I
L
A
A
A
V
-----------------
M
L
F
M
G
------------------
F
----
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
--
P
L
L
F
L
-
L
G
M
---
A
W
-------------------------
F
N
----
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
-
A
F
A
--
M
M
R
-------
D
T
---------
P
Q
S
C
G
L
P
------------
P
I
E
E
Y
K
N
D
------------------------
T
A
K
Q
---
I
F
M
Q
-
Y
V
L
P
-----------
N
K
----
L
-
L
W
Y
I
A
I
-
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V---
K
H
F
A
L
D
-
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
-------
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
-
P
-----------------------------------------------------------------------------------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
-
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
-
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
------
T
------
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------
1
PsiBlast_PDB
62.48
31%
-101
- C2 -
4LDS
-
?
A:
[25-334]
----------------------------
V
I
S
G
A
L
L
F
I
H
--------
K
D
-
I
--------
P
L
N
S
T
T
E
-------
G
--------
I
V
------
V
S
S
M
L
--------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
-
M
L
---
I
A
I
V
F
I
I
G
-----------------
A
L
I
L
A
------------------
A
----
S
---
T
----
N
-
L
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
----
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
--
Y
L
V
N
Y
-
A
F
A
---
D
I
-------------------------
E
-----
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
-
L
V
-
G
I
Y
--
F
M
P
-------
E
S
P
R
W
L
L
E
N
R-
N
E
E
A
A
R
Q
------------
V
M
K
I
T
Y
D
D
-----------
S
E
I
D
K
E
L
K
E
M
K
E
I
N
A
I
S
E
S
T
W
T
V
I
K
S
P
W
L
-----------
G
R
----
I
L
I
V
G
C
I
F
-
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
----
A
G
L
-
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
L
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
61.78
16%
-111
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
------------
D
-
L
--------
N
V
R
E
G
A
V
-------
Q
--------
S
V
------
M
G
A
Y
L
--------
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
-
L
V
---
G
M
S
I
F
M
L
A
-----------------
T
L
V
A
V
------------------
T
----
T
---
S
----
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
--
P
L
I
G
G
-
L
L
D
----
T
-------------------------
M
W
----
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
-
T
F
-
S
M
A
--
R
W
M
-------
P
E
---------
T
R
P
--------------------------------------
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
---
L
F
G
N
S
G
F
N
C
-----------
Y
L
----
L
-
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
------
G
A
V
----
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
-------
C
L
L
-----------------------------------------------------------------------------------------
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
-
G
G
-
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
------
L
------
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------
33
HHSearch
57.66
15%
-133
* C2 *
2CFQ
-
LACY_ECOLI
A:
[9-397]
------------
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
--------
H
D
I
N
--------
H
I
S
K
S
D
T
-------
G
--------
I
I
------
F
A
A
I
S
--------
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
-
L
W
I
I
T
G
M
L
V
M
F
A
P
-----------------
F
F
I
F
I
------------------
F
----
G
---
P
----
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
--
A
S
I
V
G
-
I
M
F
---
T
---------------------------
I
----
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
-
A
V
-
L
L
F
--
F
A
K
-------
T
D
---------
A
P
S
S
A
T
V
------------
A
N
A
V
G
-
A
-----------------
N
H
S
A
F
S
L
K
L
A
L
E
---
L
F
R
Q
-
P
K
L
---------------------
W
F
L
S
L
-
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FAT
G
E
Q
G
T
R
-
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
-------
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
-----------------------------------------------------------------------------------------
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
-
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
-
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
------
M
------
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------
32
HHSearch
55.12
17%
-106
- C2 -
2GFP
-
EMRD_ECOLI
A:
[16-360]
------------------
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
--------
R
D
-
L
--------
N
V
R
E
G
A
V
-------
Q
--------
S
V
------
M
G
A
Y
L
--------
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
-
L
V
---
G
M
S
I
F
M
L
A
-----------------
T
L
V
A
V
------------------
T
----
T
---
S
----
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
--
P
L
I
G
G
-
L
L
----
D
T
-------------------------
M
W
----
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
-
T
F
S
M
A
R
--
W
M
P
-------
E
T
---------
R
P
V
D
A
P
R
------------
T
---
R
------------------------
L
L
T
S
Y
K
T
---
L
F
G
N
-
S
G
F
N
-----------
C
Y
------
L
L
M
-----
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
---
L
G
L
S
S
M
-
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
-------
C
C
--
L
L
A
G
L
L
M
W
-
I
P
D
W
F
G
-----------------------------------------------------------------------------------
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
-
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
-
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
------
L
------
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------
31
HHSearch
46.74
15%
-94
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[28-331]
------------
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
--------
Q
A
-
F
--------
T
L
T
N
F
Q
A
-------
G
--------
L
I
------
Q
S
A
F
Y
--------
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
-
I
T
---
G
L
F
L
Y
A
L
G
-----------------
A
A
L
F
W
------------------
P
----
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
--
V
V
F
G
Q
-
S
L
I
---
L
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
----
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
-
A
L
-
L
I
M
L
T
K
F
P
-------
A
L
---------
Q
S
D
N
H
S
D
------------
A
---
K
---------------------
Q
G
S
F
S
A
S
L
S
R
---
L
A
R
I
-----------------
R
----
H
-
W
R
W
A
V
L
-
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I--
P
G
M
T
A
G
-
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
-------
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.08
19%
-130
- C2 -
3WDO
-
?
A:
[10-189]
----------
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M-------
A
L
-
Q
--------
G
A
S
E
A
L
I
-------
G
--------
I
A
------
I
G
I
Y
G
--------
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
-
V
G
---
G
L
A
V
F
A
A
G
-----------------
S
V
I
A
A
------------------
L
----
S
---
D
----
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
--
M
V
L
G
P
-
I
I
T
----
H
-------------------------
K
L
----
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
-
T
I
W
--
V
V
P
-------
N
S
---------
S
T
H
V
L
N
R
------------
E
S
G
M
V
K
G
S
-----------
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
---
M
C
L
H
M
L
L
M
S
-----------
T
F
----
V
-
A
L
P
G
Q
L
-
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
----
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
-------
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
-
Q
A
-
L
----------------------------------------------------------------------------------------------------