@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR11_HUMAN: (2015-12-08 )
MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALCLQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRAQGPTWRSLEVIQSTEL
Atome Classification :
(20 SA)
----------------------------------.......-..------10........20........30.......-.40........50.........60........-----70....--....80.-.......90.....-..-.100..-----.....110-----.....---------------..---120.......130.......140.......--150.......----------------160.......170....-----------...180.------------------------...------...190----.........200..---...--..210....------...220---------.........230.......240.......250.......--260........270.......280..----.-----..------..290.......300--...----------....310--........320.....----------..330.......340.......350.-......360...--------------------......------370.......380..-.....390.......400....----------...---410.......420......-----------..-----430------..-.-------..----..440.......450.......460.......470.......480......----.490....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------
M
R
A
L
R
R
L
-IQ------G
R
I
L
L
L
T
I
C
AAGIGG
T
F
Q
FG
Y
N
L
S
IINAP-
T
L
H
I
Q
E
FTNETW-QARTGEPL
P
D
H
L
V
L
L
M
W
S
L
-----
I
V
S
L
YP--
L
G
G
L
F
G
A
-
L
LAG
P
L
A
I
T
LGRK
K
-
S
L
-
L
VN
N
I
F
-----
V
V
S
A
A
I
L
F
-----GFSRK---------------AG---S
F
E
M
I
M
L
G
R
L
L
V
GVNAG
V
S
M
N
I
Q
P
M
YLGES--A
P
K
E
L
R
G
A
V
A
----------------
M
S
S
A
I
F
T
A
L
G
I
V
M
G
Q
V
V
-----------
G
L
R
E
LLG------------------------GP
Q
------
A
W
P
L
------
L
L
A
S
C
LVPG
A
L
Q
L
A---SLP--LLPESP
R
Y
L
------
L
I
DC-----------G
D
T
E
A
C
L
A
A
L
R
R
LRGSGD
L
A
G
E
L
E
E
L
E
E
E
R
A
A
C
QGCRAR--
R
P
-
W
E
L
F
Q
H
R
A
L
R
R
Q
V
T
S
L
V
V
L
G
S
A
M
----
E
-----LC------GND
S
V
Y
A
Y
A
S
S
V
F
R
K--AGV----------PE
A
K
I
Q
---
Y
A
I
IGTG
S
C
E
L
L
T
A
V
V
----------
S
C
V
V
I
E
R
VG
R
R
V
L
L
IG
G
Y
S
L
M
T
C
W
G
S
-
I
F
T
V
A
L
C
--
L
QS--------------------SF
P
W
T
L
------
Y
L
A
M
A
C
I
F
A
F
I
L
SFG-IG
P
A
G
V
T
G
I
L
A
T
E
L
F
D
Q
MAR
P
A
----------
A
C
M
---
V
C
G
A
L
M
W
I
M
L
I
-
L
V
GL
G
F
P
-----------
F
I
-----
M
E
A
------
L
S
-
H
-------
F
L
----
Y
V
P
F
L
G
V
C
V
C
G
A
I
Y
T
G
L
FLPETKG
K
T
F
Q
E
I
S
K
E
L
H
RLNFPRRAQGPTW
R
S
L
----
E
V
I
QSTEL-
1
PsiBlast_PDB
97.82
36%
-129
- C3 -
4PYP
1
GTR1_HUMAN
A:
[9-455]
-------------------------------------------
T
------
G
R
L
M
L
--
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
-
Q
K
V
I
E
E
F
Y
T
Q
T
W
-
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
M
M
N
L
L
-----
A
F
V
S
A
V
L
M
-----
G
F
S
K
L
---------------
G
K
---
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
--
S
P
T
A
L
R
G
A
L
G
----------------
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
-----------
G
L
D
S
I
M
G
------------------------
N
K
D
------
L
W
P
L
------
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
---
V
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
--
T
I
-
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
--
A
G
V
----------
Q
Q
P
V
-----
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
----------
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
--
L
L
E
--------------------
Q
L
P
W
M
S
------
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
-
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
I
A
---
V
A
G
F
S
N
W
T
S
N
F
-
I
V
G
M
C
F
Q
-----------
Y
V
-----
E
Q
L
------
C
G
-
P
-------
Y
V
----
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
------------------------------------------
17
PsiBlast_CBE
96.19
34%
-125
- C3 -
5C65
7
?
B:
[10-466]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
Q
K
T
L
-
T
D
K
--
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
---
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
-------------
E
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
--------------------
N
Y
----------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
--------------------------
3
PsiBlast_PDB
96.18
34%
-122
- C3 -
4ZW9
4
?
A:
[32-488]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
T
K
T
L
-
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
----------
Q
E
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
--------------------
N
Y
N
G
M
S
------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------
4
PsiBlast_PDB
96.14
34%
-124
- C3 -
4ZWB
1
?
A:
[32-488]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
T
K
T
L
-
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
----------
Q
E
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
--------------------
N
Y
N
G
M
S
------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------
18
PsiBlast_CBE
96.05
34%
-124
- C3 -
4ZWC
2
?
B:
[32-488]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
T
K
T
L
-
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
----------
Q
E
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
--------------------
N
Y
N
G
M
S
------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------
5
PsiBlast_PDB
95.84
34%
-126
- C3 -
4ZWC
3
?
A:
[32-488]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
T
K
T
L
-
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
G
V
----------
Q
E
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
--------------------
N
Y
N
G
M
S
------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-------------------------
2
PsiBlast_PDB
95.51
34%
-125
- C3 -
5C65
8
?
A:
[10-466]
-----------------------------------------------------
L
I
F
A
I
T
V
A
T
I
G
-
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
-
E
K
I
I
K
E
F
I
Q
K
T
L
-
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
-----
S
V
A
I
F
S
--
V
G
G
M
I
G
S
-
F
S
V
G
L
F
V
N
R
F
G
R
R
N
-
S
M
-
L
I
V
N
L
L
-----
A
V
T
G
G
C
F
M
-----
G
L
C
K
V
---------------
A
K
---
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
--
S
P
T
A
L
R
G
A
F
G
----------------
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
-----------
G
L
E
F
I
L
G
------------------------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
---
A
L
P
--
F
C
P
E
S
P
R
F
L
------
L
I
N
R
-----------
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
--
T
V
-
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
----
Q
-----
L
S
------
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
--
A
--------------
P
I
-----
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
----------
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
--
L
K
D
------------------------
M
S
------
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
-
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
----------
A
M
A
---
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
-----------
S
A
-----
A
H
Y
------
L
G
-
A
-------
Y
V
----
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
--------------------------
19
Fugue
83.19
23%
-110
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-------------------------------------------
Y
------
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-
V
E
S
L
N
T
V
F
V
-------
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
-----
C
V
A
S
A
L
--
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
-----
F
F
I
S
G
V
G
S
-----
A
W
P
E
L
GFTSINPDNTVPVYL
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
-----------
N
Y
F
I
A
R
S
------------------------
G
D
A
S
W
L
N
T
D
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
S
R
------------
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
--
L
L
-
M
F
G
------
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
----
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
----------
S
T
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
--
T
Q
A
--------------------
P
G
I
V
A
L
------
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
-----
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
-----
D
K
N
------
S
W
-
L
V
A
H
FHNG
F
S
----
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
--------------
W
E
---------------
20
Fugue
78.11
24%
-128
- C3 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
----------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-
V
E
S
L
N
T
V
----
F
-
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
-----
C
V
A
S
A
L
--
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
-----
F
F
I
S
G
V
G
S
A
WPEL
G
F
T
S
I
NPDNTVPVYL-----
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
-----------
N
Y
F
I
A
R
S
------------------------
G
D
A
------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
-------------------------------
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
---------------
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
----
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
----------
S
T
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
--
T
Q
A
--------------------
P
G
I
V
A
L
------
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
-----
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
DKN
S
W
L
V
A
------
H
F
-
H
NG-----
F
S
----
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-------------------------------------
6
PsiBlast_PDB
77.88
28%
-128
- C3 -
4LDS
-
?
A:
[46-427]
---------------------------------------------------------------------------------------------------------------
I
-----
V
V
S
S
M
L
--
I
G
A
I
V
G
A
-
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
-
L
I
A
I
V
F
-----
I
I
G
A
L
I
L
---------
A
A
---------------
S
T
---
N
L
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
--
A
P
T
E
Y
R
G
S
L
G
----------------
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
-----------
N
Y
A
--
F
A
------------------------
D
I
E
------
G
W
R
W
------
M
L
G
L
A
V
V
P
S
V
I
L
L
V
---
G
I
Y
--
F
M
P
E
S
P
R
W
L
------
L
-
E
N
-----------
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
N
A
I
S
E
S
T
--------
W
T
V
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
----
Q
-----
F
I
------
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
--
A
G
L
----------
G
E
A
A
S
I
---
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
----------
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
--------
S
L
L
--
I
M
A
--------------------
I
L
I
W
T
I
GIA
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
-
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
----------
A
T
G
---
I
S
A
L
V
L
N
I
G
T
L
-
I
V
S
L
F
F
P
-----------
I
L
-----
S
D
A
------
L
S
T
E
-------
W
V
----
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
----------------------------------------
7
PsiBlast_PDB
71.59
23%
-124
- C3 -
4GBY
5
XYLE_ECOLI
A:
[66-474]
-----------------------------------------------------------------------------------------------------------------------------
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
-----
G
F
T
S
I
NPDNTVPVYL-----
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
----
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
L
-------------------------
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
-
S
R
-----------
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
-------------
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
----------
S
T
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
-
M
F
S
L
G
T
A
--
F
Y
T
--------------------
Q
A
P
G
I
--------
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
-
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
-----
D
K
N
S
W
L
---
V
A
-
H
-------
F
H
NG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------------------
9
PsiBlast_PDB
71.29
23%
-121
- C3 -
4GC0
5
XYLE_ECOLI
A:
[66-474]
-----------------------------------------------------------------------------------------------------------------------------
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
-----
G
F
T
S
I
NPDNTVPVYL-----
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
----
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
L
-------------------------
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
-
S
R
-----------
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
-------------
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
----------
S
T
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
-
M
F
S
L
G
T
A
--
F
Y
T
--------------------
Q
A
P
G
I
--------
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
-
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
-----
D
K
N
S
W
L
---
V
A
-
H
-------
F
H
NG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------------------
8
PsiBlast_PDB
70.43
23%
-124
- C3 -
4GBZ
5
XYLE_ECOLI
A:
[66-474]
-----------------------------------------------------------------------------------------------------------------------------
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
-----
G
F
T
S
I
NPDNTVPVYL-----
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
----
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
L
-------------------------
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
-
S
R
-----------
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
-------------
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
--
L
G
A
----------
S
T
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
-
M
F
S
L
G
T
A
--
F
Y
T
--------------------
Q
A
P
G
I
--------
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
-
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
-----
D
K
N
S
W
L
---
V
A
-
H
-------
F
H
NG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------------------
10
PsiBlast_PDB
69.43
23%
-132
- C3 -
4JA4
-
XYLE_ECOLI
A:
[66-474]
-----------------------------------------------------------------------------------------------------------------------------
I
G
C
I
I
G
G
-
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
-
S
L
-
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
-----
G
F
T
S
I
N
P
D
N
T
V
PVYL-----
A
G
---
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
--
A
P
A
H
I
R
G
K
L
V
----------------
S
----
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
RS
G
D
A
S
W
L
-------------------------
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
M
---
L
L
Y
--
T
V
P
E
S
P
R
W
L
------
M
----------------
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
---------------------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----
F
V
------
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------------------
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
----------
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
-
M
F
S
L
G
T
A
--
F
Y
T
--------------------
Q
A
P
G
I
--------
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
-
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
----------
A
L
A
---
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
-----------
M
M
-----
D
K
N
SW-----------------NG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------------------
27
Fugue
61.12
14%
-104
- C3 -
1HBN
4
MCRB_METTM
B:
[1-442]
------------------------------------------------------------------
A
K
F
E
D
K
V
D
L
Y
D
D
R
G
N
L
V
E
E
Q
V
P
L
E
A
L
-
S
P
L
R
N
P
A
I
K
S
I
V
Q
G
I
K
R
T
V
-----
A
V
N
L
E
G
--
I
E
N
A
L
K
T
A
K
V
G
G
P
A
C
K
I
M
G
R
E
L
-
D
L
D
I
V
G
N
A
E
-----
S
I
A
A
A
A
K
E
-----
M
I
Q
V
T
---------------
E
D
DD
T
N
V
E
L
L
G
G
G
K
R
A
L
V
Q
V
P
S
A
R
F
D
V
A
A
E
Y
------
S
A
A
P
L
V
T
A
T
A
----------------
F
V
Q
A
I
I
N
E
F
D
V
S
M
Y
D
A
N
-----------
M
V
K
A
A
V
L
------------------------
G
R
Y
------
P
Q
S
V
------
E
Y
M
G
A
N
I
A
T
M
L
------
D
I
P
--
Q
K
L
E
G
P
G
Y
A
------
L
R
N
I
-----------
M
V
N
H
V
V
A
A
T
----
L
K
N
T
L
Q
A
A
A
L
S
T
I
L
E
Q
T
A
M
F
E
M
G
D
A
V
--
G
A
-
F
E
R
M
H
L
L
G
L
A
Y
Q
G
--------------------
M
N
------
A
D
N
L
V
F
D
L
V
K
A
N
G
K
E
--
G
T
---------------------------
V
G
S
V
I
A
D
L
V
----------
E
R
A
L
E
D
G
V
I
K
V
E
K
E
L
T
D
Y
K
V
Y
G
T
--------------
D
D
--------------------
L
A
M
W
N
A
------
Y
A
A
A
G
L
M
A
A
T
M
V
N
Q
G
-
A
A
R
A
A
Q
G
V
S
S
T
L
L
Y
Y
N
D
L
I
E
F
E
TGLPSVDFG
K
V
E
G
---
T
A
V
G
F
S
F
F
S
H
S
-
I
Y
G
G
G
G
P
-----------
G
I
-----
F
N
G
NHIVTR
H
S
-
K
-------
G
F
----
A
I
P
C
V
A
A
A
M
A
L
D
A
G
T
Q
M
F
S
P
E
A
T
S
G
L
I
K
E
V
F
S
Q
V
D
E
F
R
E
P
L
K
Y
V
V
E
A
A
A
E
I
----
K
----
N
E
I
-
30
HHSearch
59.22
14%
-114
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[34-409]
----------------------------------------------------------------
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
-
L
P
Q
F
Q
Q
A
F
---------------
T
L
T
N
F
Q
A
G
L
-----
I
Q
S
A
F
Y
--
F
G
Y
F
I
I
P
-
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
-
G
I
-
I
T
G
L
F
L
-----
Y
A
L
G
A
A
L
F
-----
W
P
A
A
E
---------------
I
M
---
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
--
G
P
E
S
S
G
H
F
R
L
----------------
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
-----------
G
Q
S
L
I
L
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
------
S
V
Q
T
------
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
---
L
I
M
L
T
K
F
P
A
L
Q
S
----------
D
N
------------
H
S
D
A
---------------------------
K
Q
G
S
F
S
A
--
S
L
-
S
R
L
A
R
I
R
H
W
R
W
A
V
-----
L
A
Q
F
C
----
Y
-----
V
G
------
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
----------
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
----------
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
-
I
S
A
F
A
G
---------------------------
G
-
H
--------
V
-
G
L
I
A
L
T
L
C
S
A
F
M
--
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
----------
G
S
S
---
F
I
-
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
-----------
F
V
-----
S
D
A
------
A
G
-
N
-------
I
P
----
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------
25
Fugue
58.15
17%
-118
- C3 -
4RIC
4
FAN1_HUMAN
A:
[1-631]
TGHP
Y
Y
L
R
S
F
L
V
V
L
K
T
V
L
E
N
E
D
D
M
L
L
F
D
E
Q
E
K
G
I
V
T
K
F
Y
Q
L
S
A
T
------
G
Q
K
L
Y
V
R
L
F
Q
R
K
L
S
W
I
K
M
T
K
L
E
Y
E
E
I
A
L
D
L
T
P
V
I
E
E
L
T
N
A
G
F
-
L
Q
T
E
S
E
L
Q
E
L
S
E
V
L
E
L
L
S
A
P
E
L
K
S
L
A
K
T
F
H
--
L
V
N
P
N
G
Q
-
K
Q
Q
L
V
D
A
F
L
K
L
A
K
Q
-
R
S
-
V
I
G
A
V
I
-----
L
K
R
A
K
A
L
A
-----
G
Q
S
V
R
---------------
I
C
---
K
G
P
R
A
V
F
S
R
I
L
L
L
F
S
L
T
D
S
M
E
D
E
D
A
A
C
G
G
Q
GQ
L
S
T
V
L
L
V
N
L
G
R
M
E
F
P
S
Y
T
I
N
R
K
T
HIF
Q
D
R
D
D
L
I
R
Y
A
A
A
T
H
M
L
S
-----------
D
I
S
S
A
M
A
N
-----------------------
G
N
W
------
E
E
A
K
------
E
L
A
Q
C
A
K
R
D
W
N
R
L
K
NH
P
S
L
R
--
C
H
E
D
L
P
L
F
L
R
C
F
T
V
G
W
I
Y
T
-----------
R
I
L
S
R
F
V
E
I
L
Q
R
L
H
M
Y
E
E
A
V
R
E
L
E
S
L
L
S
Q
R
I
Y
C
P
D
S
R
G
R
W
W
D
R
-
L
A
L
N
L
H
Q
H
L
K
R
L
E
P
T
I
K
C
I
T
E
G
L
----
A
DPEVR
T
G
------
H
R
L
S
L
Y
Q
R
A
V
R
L
R
E
S
--
P
S
C
KKFKHLFQQL
P
E
M
A
V
Q
---
D
V
K
H
V
T
I
T
G
R
L
C
K
S
V
F
V
MVLCS
V
E
E
L
A
L
A
H
Y
R
R
S
G
F
D
Q
G
I
H
G
E
G
S
T
F
S
T
L
Y
G
-
L
L
L
W
D
I
I
--
F
M
D
GIPDVFRNACQAFPLDLCTD
S
F
F
T
S
R
------
R
P
A
L
E
A
R
L
Q
L
I
H
D
---
A
P
E
E
S
L
R
A
W
V
A
A
T
W
H
E
Q
E
G
R
V
A
----------
S
L
V
SWD
R
F
T
S
L
Q
Q
A
Q
D
L
-
V
S
C
L
G
G
P
-----------
V
L
-----
S
G
V
------
C
R
-
H
-------
L
------
A
A
D
F
R
H
C
R
G
G
L
P
D
L
V
V
W
N
S
Q
S
R
H
F
K
L
V
E
V
K
G
P
N
D
R
L
S
H
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
E
V
C
H
V
V
A
V
-
29
HHSearch
54.75
12%
-115
- C3 -
1PW4
-
GLPT_ECOLI
A:
[59-414]
-------------------------------------------------------------------------------------------------------
G
F
S
R
G
D
L
G
F
-----
A
L
S
G
I
S
--
I
A
Y
G
F
S
K
-
F
I
M
G
S
V
S
D
R
S
N
P
R
V
-
F
L
-
P
A
G
L
I
L
-----
A
A
A
V
M
L
F
M
-----
G
F
V
P
W
A
--------------
T
S
---
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
--
W
S
Q
K
E
R
G
G
I
V
----------------
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
-----------
F
L
L
G
M
-
A
------------------------
W
F
N
------
D
W
H
A
------
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
--
A
F
A
--
M
M
R
D
T
P
Q
S
C
------
G
--
L
-----------
P
P
I
E
E
Y
K
N
------------
D
--------------
T
A
K
Q
--
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
-----
I
A
I
A
N
V
F
----
V
-----
Y
L
------
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V-
K
H
F
----------
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
----------
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
---
P
A
--------------------
G
---
N
P
------
T
V
D
M
I
C
M
I
--
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
----------
A
A
G
---
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
-----------
Y
T
-----
V
D
F
------
F
G
-
W
-------
D
G
----
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------
28
Fugue
54.59
14%
-108
- C3 -
2OCC
-
COX1_BOVIN
A:
[1-514]
----------------------------------
M
F
I
N
R
W
L
-
F
S
TN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
G
Q
P
-
G
T
L
L
G
-------D
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
F
F
M
-----
V
M
P
I
M
I
GG
F
G
N
W
L
V
P
-
L
M
I
G
A
P
D
M
A
F
P
R
M
N
-
N
M
-
S
F
W
-
L
L
-----
P
P
S
F
L
L
L
L
-----
A
S
S
M
V
---------------
E
--------
A
G
A
G
---
T
G
W
T
V
Y
P
P
L
A
G
N
L
A
H
A
G
A
S
--
V
D
L
T
I
F
S
L
H
L
----------------
A
G
V
S
S
I
L
G
A
I
N
F
I
T
T
I
I
-----------
N
M
K
P
P
A
M
------------------------
S
Q
Y
------
Q
T
P
L
------
F
V
W
S
V
M
I
T
A
V
L
L
L
L
---
S
L
P
--
V
L
A
A
G
I
T
M
L
------
L
T
D
R
NLNTTFFDPAG
G
G
D
P
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
M
I
S
H
I
V
T
Y
Y
S
G
--
K
K
--
E
P
F
G
Y
M
G
M
V
W
A
M
M
S
I
G
F
L
G
F
I
V
----
W
-----
A
H
HMFTVG
M
D
V
D
T
R
A
Y
F
T
S
A
T
M
I
--
I
A
I
----------
P
T
G
V
K
V
---
F
S
W
L
A
T
L
H
G
G
N
I
K
W
S
P
----------
A
M
M
W
A
L
G
F
-
I
F
L
F
T
V
G
G
L
T
G
I
V
L
A
N
S
-
S
L
D
I
V
L
H
DT
Y
Y
V
--------------------
V
A
H
F
H
Y
------
V
L
S
M
G
A
V
F
A
I
M
G
G
F
V
-
H
W
F
P
L
F
S
G
Y
T
L
N
D
T
W
A
K
I
H
F
A
I
----------
M
F
V
---
G
V
N
M
T
F
F
P
Q
H
F
-
L
G
L
S
G
M
P
R
RYSDYPDAY
T
M
W
-----
N
T
I
------
S
S
-
M
-------
G
S
----
F
I
S
L
T
A
V
M
L
M
V
F
I
I
W
E
A
F
A
S
K
R
E
V
L
---
T
V
D
L
T
T
T
N
L
E
W
L
N
G
C
P
-
P
P
Y
H
T
F
----
E
E
P
T
Y
V
N
L
K
31
HHSearch
54.57
14%
-130
- C3 -
3WDO
-
?
A:
[42-366]
-------------------------------------------------------------------------------------------------------
G
A
S
E
A
L
I
G
I
-----
A
I
G
I
Y
G
--
L
T
Q
A
V
F
Q
-
I
P
F
G
L
L
S
D
R
I
G
R
K
P
-
L
I
-
V
G
G
L
A
V
-----
F
A
A
G
S
V
I
A
-----
A
L
S
------------------
D
---
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
--
T
R
E
Q
N
R
T
K
A
M
----------------
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
-----------
G
--
P
I
I
T
------------------------
H
K
L
------
G
L
H
A
------
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
--
T
I
W
--
V
V
P
N
S
S
T
H
V
------
L
---------------
N
R
E
S
-
G
----------------------------
M
V
K
G
--
S
F
-
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
--------------
M
------
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
--
A
G
F
----------
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
----------
Y
A
E
V
K
R
K
M
K
Q
--
V
F
V
F
C
V
G
L
I
V
V
A
E
I
-
V
L
W
N
A
------
Q
--------------------
T
---
Q
F
------
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
--
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
----------
A
M
G
---
V
Y
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
-----------
W
I
-----
D
G
M
------
F
D
-
G
-------
Q
G
----
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
----
V
K
E
V
L
I
A
E
-