@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT10_HUMAN: (2015-12-08 )
MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60........70........80........90........-100........110.......120.......130.......140......---.150.......160---.----..---....170.......180.----......190...-.-...200...-....210.......220....--------------------------...----230.......240.......250........260..-.....270.......280.......290.......300.......310.......----320.........---330.......340.......350...--....360.......370......--.----380.......390.......400.......410.......420.-......430.-.......440.......450.......460.......470.......480.......490.......500.......510...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSD
S
P
E
A
A
V
E
K
V
E
V
E
LAG-PATAEPHEPPEPPEG
G
W
G
W
L
V
M
L
A
A
M
WCNGSVF
G
I
Q
N
A
C
G
V
L
F
V
S
M
L
-
E
T
-FGSKDDD
K
M
V
F
K
T
A
WVGSLS
M
G
M
I
F
F
C
C
P
I
V
S
V
F
T
D
L
FGC
R
K
T
A
V
V
G
---
A
A
V
G
F
V
G
L
M
S
S
S
F
V
---
S
----SI---
E
P
L
Y
L
T
Y
G
I
I
F
ACGCSFA----YQP
S
L
V
I
L
G
H
Y
F
-
K
-
K
R
L
G
L
V
N
G
I
-
V
TA
G
S
S
V
F
T
I
L
L
P
L
L
L
R
V
L
I
D--------------------------S
V
G
----
L
F
Y
T
L
R
V
L
C
I
F
M
F
V
L
F
LAGFTY-RPLATSTKDKESG-GSGSSLFSRKKFS
P
P
K
K
I
F
N
F
A
I
F
K
V
T
A
Y
A
V
W
AV
G
I
P
L
A
L
F
G
Y
F
V
P
Y
V
H
L
M
K
H
V
N
----
E
--
R
F
QDEKN
K
E
---
V
V
L
M
C
I
GVTS
G
V
G
R
L
L
F
G
R
I
A
D
YVP
G
--
V
K
K
V
Y
L
Q
V
L
S
F
F
F
I
G
L
M
S
M
M
I
P
L
--
C
----
S
I
F
G
A
L
I
A
V
C
L
I
M
G
L
F
D
G
C
F
I
S
I
M
A
P
I
A
F
E
LV
G
A
Q
D
V
S
Q
A
I
G
F
L
-
L
G
F
M
SIP-MT-VGP
P
I
A
G
L
L
R
D
KLGSY
D
V
A
F
Y
LAGV
P
P
L
IG
G
A
V
L
C
F
I
PWIH
S
K
K
Q
R
E
I
S
KTT
G
K
E
K
M
E
K
M
L
E
N
Q
N
S
L
LSSSSGMFKKESDSII
12
Fugue
93.32
13%
-141
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------
F
K
P
A
P
H
K
A
R
L
----------------------
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
-
E
Q
-
G
F
S
R
G
D
------
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
-
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
DWHA
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
-
T
P
Q
S
C
G
L
P
P
I
E
E
Y
-
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
----
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
-----
E
----
V
--
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
GN
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
--
A
----
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
-
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------------
21
HHSearch
82.63
13%
-147
- C3 -
1PW4
-
GLPT_ECOLI
A:
[23-431]
------------------------------------------------------------------
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
-
Q
G
F
S
R
-----
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
---
A
V
M
F
V
L
L
-
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
-
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
----
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
----
E
V-
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
--
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
NP
A
----
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
-
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------
24
HHSearch
68.21
12%
-125
- C3 -
2GFP
-
EMRD_ECOLI
A:
[22-360]
--------------------------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
-
R
D
-
L
N
V
R
E
-----
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
---
T
V
L
I
A
A
S
-
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
-
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
----
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
-
M
P
E
T
R
P
V
D
A
P
R
---
T
-------------
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
----
A
V
-
L
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
-
S
--
T
L
M
W
Q
S
V
-
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
----
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
I
G
-
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------
23
HHSearch
66.94
10%
-138
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[34-421]
--------------------------------------------------------------------------------
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
A
-
F
T
L
T
N
-----
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
---
T
L
F
L
V
G
L
-
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
-
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
----
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
--
N
H
-
S
-
D
A
---------
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
----
E
E
I
P
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
-
A
--
P
H
K
V
L
A
A
--
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
--
A
----
G
G
H
V
G
-
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
T
I
I
G
-
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-------------------------------------------
26
HHSearch
65.96
16%
-149
* C3 *
3WDO
-
?
A:
[13-177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
----
A
L-
Q
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
-
G
--
R
K
P
L
I
V
--
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
--
S
----
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
-
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
22
HHSearch
65.91
11%
-145
- C3 -
3WDO
-
?
A:
[29-379]
-------------------------------------------------------------------------------------------
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
-----
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
---
W
G
I
I
L
G
R
-
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
-
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
----
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
-
V
P
N
S
S
T
H
V
L
N
R
E
S
-
G
-------------
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
----
D
--
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
-----
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
-
I
V
L
W
N
A
--
Q
----
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
-
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
25
HHSearch
65.44
12%
-134
- C3 -
2CFQ
-
LACY_ECOLI
A:
[24-394]
-----------------------------------------------------------------------------------------
G
A
Y
F
P
F
F
P
I
W
L
-
H
D
I
N
H
I
S
K
-----
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
--
Y
N
I
L
V
G
S
-
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
---
R
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
----
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
A
P
S
S
A
T
V
A
-
N
-
A
V
G
------
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FA
T
--
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
-
G
--
G
K
N
A
L
L
--
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
--
A
----
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
-
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------
27
HHSearch
55.44
20%
-110
- C3 -
2GFP
-
EMRD_ECOLI
A:
[25-172]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
Y
I
P
A
I
A
D
M
A
R
----
D
--
L
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
-
G
--
R
R
P
V
I
L
V
--
G
M
S
I
F
M
L
A
T
L
V
A
V
T
--
T
----
S
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
I
L
V
S
-
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
30
HHSearch
47.72
12%
-141
- C3 -
2CFQ
-
LACY_ECOLI
A:
[259-397]
------------------------------------------------------------------------------------------------------------------
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
---
L
E
V
V
I
L
K
-
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
-
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
----
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
-
V
N
E
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
46.69
10%
-165
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[39-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
----
A
--
F
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
-
S
--
Y
K
A
G
I
I
--
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
--
A
A
E
I
-
M
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
G
-
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
9
PsiBlast_PDB
43.10
41%
-84
- C1 -
1G51
-
SYD_THETH
A:
[79-114]
----------------------------------
P
E
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
-
R
L
-
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
---
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
---
M
----
V
A
---
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
----
A
D
R
Q
P
D
F
T
Q
L
D
L
-
E
-
M
S
F
V
E
V
E
D
V
-
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
L
P
--------------------------
L
P
F
----
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
-
L
E
L
K
E
V
G
P
L
F
R
Q
S
-
G
F
R
V
F
Q
E
A
E
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
G
G
F
S
G
G
V
A
----
K
--
F
L
E
P
V
R
E
A
L
---
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
--
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
F
R
F
L
W
V
--
V
----
D
F
P
L
L
E
W
D
E
E
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
-
D
L
V
L
N
G
V
-
E
V
-
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
8
PsiBlast_PDB
43.08
41%
-65
- C1 -
1EFW
-
SYD_THETH
A:
[79-114]
----------------------------------
P
E
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
-
R
L
-
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
---
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
---
M
----
V
A
---
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
----
A
D
R
Q
P
D
F
T
Q
L
D
L
-
E
-
M
S
F
V
E
V
E
D
V
-
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
L
P
--------------------------
L
P
F
----
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
-
L
E
L
K
E
V
G
P
L
F
R
Q
S
-
G
F
R
V
F
Q
E
A
E
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
G
G
F
S
G
G
V
A
----
K
--
F
L
E
P
V
R
E
A
L
---
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
--
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
F
R
F
L
W
V
--
V
----
D
F
P
L
L
E
W
D
E
E
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
-
D
L
V
L
N
G
V
-
E
V
-
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
29
HHSearch
42.89
10%
-136
- C3 -
1PW4
-
GLPT_ECOLI
A:
[54-200]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
----
E
--
Q
G
F
S
R
G
D
L
G
---
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
--
P
R
V
F
L
P
--
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
--
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
H
N
V
G
-
G
G
-
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
10
PsiBlast_PDB
41.48
41%
-59
* C1 *
1L0W
-
SYD_THETH
A:
[79-114]
----------------------------------
P
E
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
K
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
-
R
L
-
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
---
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
---
M
----
V
A
---
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
----
A
D
R
Q
P
D
F
T
Q
L
D
L
-
E
-
M
S
F
V
E
V
E
D
V
-
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
L
P
--------------------------
L
P
F
----
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
-
L
E
L
K
E
V
G
P
L
F
R
Q
S
-
G
F
R
V
F
Q
E
A
E
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
G
G
F
S
G
G
V
A
----
K
--
F
L
E
P
V
R
E
A
L
---
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
--
G
A
V
R
L
R
A
A
D
L
L
G
L
K
R
E
G
F
R
F
L
W
V
--
V
----
D
F
P
L
L
E
W
D
E
E
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
-
D
L
V
L
N
G
V
-
E
V
-
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
20
Fugue
36.89
17%
224
- C2 -
1HF9
-
ATIF1_BOVIN
A:
[1-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
--
19
Fugue
36.86
17%
224
- C2 -
1HF9
-
B:
[1-41]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
--
1
PsiBlast_PDB
35.77
37%
78
- C2 -
3BH3
1
ADC_CHRVO
A:
[87-129]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
R
G
S
Y
T
L
A
M
F
L
D
D
Q
P
P
L
A
G
G
R
E
L
W
G
F
P
K
K
A
G
K
P
R
L
E
V
H
Q
D
T
L
V
G
S
L
D
F
G
P
V
R
I
A
T
G
T
M
G
Y
K
Y
E
A
L
D
R
S
A
L
L
A
14
Fugue
33.96
18%
239
- C2 -
2L5G
-
GPS2_HUMAN
A:
[53-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
M
E
E
R
M
S
L
E
E
T
K
E
Q
I
L
K
L
E
E
K
L
L
A
L
Q
E
E
K
H
Q
L
F
L
Q
L
-----
17
Fugue
32.45
13%
261
* C2 *
3VIE
-
?
B:
[116-151]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
T
W
E
R
E
I
E
N
Y
T
R
Q
I
Y
R
I
L
E
E
S
Q
E
Q
Q
D
R
N
E
R
D
L
L
E
----------
2
PsiBlast_PDB
30.96
37%
95
- C2 -
3BGT
-
ADC_CHRVO
A:
[87-129]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
R
G
S
Y
T
L
A
-
F
L
D
D
Q
P
P
L
A
G
G
R
E
L
W
G
F
P
K
K
A
G
K
P
R
L
E
V
H
Q
D
T
L
V
G
S
L
D
F
G
P
V
R
I
A
T
G
T
M
G
Y
K
Y
E
A
L
D
R
S
A
L
L
A