@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT1_HUMAN: (2015-12-08 )
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
Atome Classification :
(20 SA)
.........----10........20.......-.30........40......-..50.........60........70........80........90---........100....---.----..-110--.---.......120.......130.......-140-........--.-150.......160.......170------------------------...-......180.......190.......200.......210-----------........220.......230.......240.......250.......260.......270.......280.....----..290.........---300.......310.......320.......330.......340.......--350--..-.......360.......370.......380.......390.-.-...-..400-.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPPAVGGPV----GYTPPDGG
W
G
W
A
V
V
I
G
A
F
I
-
S
IGFSYAFP
K
S
I
T
V
F
F
K
E
I
-
E
G
I
-
F
HATT
S
E
V
S
W
I
S
S
I
M
L
A
V
MYGG
G
P
I
S
S
I
L
V
N
KYG
S
R
I
V
M
I
V
---
G
G
C
L
S
G
C
G
L
I
A
A
S
F
C
---
N
----
T
V
-
Q
Q
---
L
---
Y
V
C
I
G
V
IGGL
G
L
A
FNL
N
P
A
L
T
M
I
G
K
Y
F
-
Y
---KRRPLANG--L-AMAGS
P
V
F
L
C
TLA
P
L
N
Q
V
F
F
G
--------------------------
I
FG-WR
G
S
F
L
I
L
G
G
L
L
L
N
C
C
V
A
G
A
L
MRPIGPKPTKAGKD
K
S
K
------------
A
S
L
E
K
AGKS
G
V
K
K
D
LHDAN
T
D
L
IGRH
P
K
Q
E
K
R
S
V
F
Q
T
I
N
Q
F
L
D
L
T
L
F
THR
G
F
L
L
Y
LSG
N
V
I
M
F
F
G
L
F
A
P
L
V
F
L
S
SY----GKS--QHYS
S
E
K
S
A
---
F
L
L
S
I
L
A
F
V
D
M
VARPSMGLVANTKPIR
P
R
I
Q
Y
F
F
A
A
S
V
V
AN
G
V
C
H
M
LAP
L
--
S
----
T
T
-
Y
V
G
F
C
V
Y
A
G
F
F
G
F
A
F
G
W
L
S
S
V
L
F
E
T
L
M
D
LV
G
P
Q
R
F
S
SA
V
G
L
-
V
-
T
I
V
-
E
C
C
P
V
-LLG
P
P
L
L
G
R
L
N
D
M
YGDY
K
Y
T
Y
W
A
C
G
V
V
L
I
I
S
G
I
Y
L
F
IGMGI
N
Y
R
L
L
A
K
E
Q
KA
N
E
Q
K
K
ESKEEETSIDVAGKP
N
E
V
T
KAAESPDQKDTDGGPKEEESPV
22
Fugue
86.94
10%
-118
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
F
K
P
A
P
H
K
A
R
LPAA
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
-
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
E
--
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
---
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
-
T
S
SIA
V
---
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
---
K
E
R
G
G
I
V
S
--
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
------------
K
N
D
T
A
---------------------------------
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L---
K
E
V
--
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
--
P
----
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
-------
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------
4
HHSearch
84.42
11%
-116
- C2 -
1PW4
-
GLPT_ECOLI
A:
[17-430]
--------
A
----
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
-
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
---
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
-
A
V
---
M
---
F
V
L
-
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
-
S
Q--
K
E
R
G
G
I
V
S
--
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
------------
K
N
-
D
--------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
----
L
K
E
V-
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
-
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
NP
A
----
G
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
-
T
-
G
L
F
-
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------------
5
HHSearch
75.76
11%
-118
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[22-420]
---------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
---
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
-
T
L
---
F
---
L
V
G
-
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
-
P
E--
S
S
G
H
F
R
L
N
--
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
L
T
-
K
F
P
A
L
Q
S
D
N
-
H
S
D
A
-------------
K
----------------------------
Q
G
S
F
S
A
S
-----
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
----
A
V
E
E
I
P
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
-
V
L
A
A
Y
--
A
L
I
A
M
A
L
-
C
L
I
S
A
F
--
A
----
G
G
-
H
V
G
-
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
-
I
--
V
M
-
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
---------------------------------------------------------
24
Fugue
74.81
10%
-100
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
--------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
-
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
-
N
H
----
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
---
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
-
P
L
---
L
Q
YN
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
-
E
---
K
V
S
R
R
S
N
F
EF
G
-
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
--------------------------
T
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
------------
N
H
---------------------
S
A
F
S
L
K
L
A
L
E
L
F
R
------------
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
----
F
T
S
--
F
F
A
T
G
E
Q
G
T
---
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
--
A
----
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
-
C
F
C
F
F
-
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
--------
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------
6
HHSearch
73.07
12%
-122
- C2 -
3WDO
-
?
A:
[30-375]
---------------------------------------------
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
---
G
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
---
I
---
I
L
G
-
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
-
R
E--
Q
N
R
T
K
A
M
A
--
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
---
R
E
S
-------------
G
--------------------------
M
----
V
K
G
S
F
-----
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
----
L
A
D
--
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
--
K
Q
--
V
F
V
F
C
V
G
L
I
V
V
A
E
-
I
V
L
W
N
A
--
Q
----
T
Q
-
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
-
Y
-
S
T
S
-
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
8
HHSearch
70.29
13%
-113
- C2 -
2CFQ
-
LACY_ECOLI
A:
[25-393]
-------------------------------------------
A
Y
F
P
F
F
P
I
W
-
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
Y
N
---
I
---
L
V
G
-
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
-
E
K
V
S
R
R
S
N
F
E
F
G
--
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
-
T
V
--
A
N
A
------------
V
G
-------------------------
A
N
-
H
--
S
A
F
S
L
K
L
--
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
--
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
-
A
-
L
L
L
--
A
G
T
I
M
S
V
R
I
I
G
S
S
F
--
A
----
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
-
C
F
F
-
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------
7
HHSearch
66.85
16%
-87
- C2 -
2GFP
-
EMRD_ECOLI
A:
[24-360]
-----------------------------------------
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
---
G
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
---
L
---
I
A
A
-
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
-
E
R
--
T
Q
L
R
H
A
N
S
--
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
---
D
A
P
R
T
-----------------------------------------
R
----
L
L
T
S
Y
-----
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
----
M
G
A
V
-
L
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
-
T
L
M
W
Q
S
V
I
--
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
----
M
N
-
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
-
V
-
G
G
L
-
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------------------------------------------------
9
HHSearch
62.24
15%
-143
- C2 -
3WDO
-
?
A:
[12-175]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
----
G
M
A
L-
Q
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
-
P
L
-
I
V
G
--
G
L
A
V
F
A
A
G
S
V
I
A
A
L
--
S
----
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
-
I
-
G
V
S
-
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
12
HHSearch
47.36
13%
-112
- C2 -
1PW4
-
GLPT_ECOLI
A:
[54-199]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----
L
V
E
--
Q
G
F
S
R
G
D
L
G
---
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
-
V
F
L
-
P
A
--
G
L
I
L
A
A
A
V
M
L
F
M
G
F
--
V
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
-
W
-
N
C
A
-
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
13
HHSearch
47.17
14%
-91
- C2 -
2CFQ
-
LACY_ECOLI
A:
[257-391]
------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
---
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
I
L
-
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
-
E
V--
R
F
S
A
T
I
Y
L
--
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
------------
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
42.30
10%
-117
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[39-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
----
Q
Q
A
--
F
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
--
G
I
I
T
--
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
--
A
A
E
I
-
M
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
-
A
-
Q
T
F
-
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
30
Fugue
41.89
11%
169
- C2 -
4M3L
4
TRI63_HUMAN
A:
[1-60]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
T
L
Y
A
I
L
D
E
K
K
S
E
L
L
Q
R
I
T
Q
E
Q
E
E
K
L
S
F
I
E
A
L
I
Q
Q
Y
Q
E
Q
L
D
K
S
T
K
L
V
E
T
A
I
Q
S
L
D
E
P
--
25
Fugue
41.67
16%
214
- C2 -
1A02
2
F:
[3-55]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
I
R
R
E
R
N
K
M
A
A
A
K
S
R
N
R
R
R
E
L
T
D
T
L
Q
A
E
T
D
Q
L
E
D
E
K
S
A
L
Q
T
E
I
A
N
L
L
K
E
K
E
K
--
11
HHSearch
41.56
12%
-116
- C2 -
2GFP
-
EMRD_ECOLI
A:
[26-170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
I
P
A
I
A
D
M
----
A
R
D
--
L
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
-
P
V
I
-
L
V
--
G
M
S
I
F
M
L
A
T
L
V
A
V
T
--
T
----
S
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
-
L
-
N
M
G
-
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
-
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
29
Fugue
41.16
15%
221
- C2 -
4CGB
-
EMAL2_HUMAN
A:
[5-48]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
D
R
V
S
A
L
E
Q
R
L
Q
L
Q
E
D
E
L
A
V
L
K
A
A
L
A
D
A
L
R
R
L
R
A
C
E
E
Q
G
A
A
L
----------
26
Fugue
41.04
22%
262
* C2 *
1ZXA
-
KGP1_HUMAN
A:
[9-44]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
I
L
M
L
K
E
E
R
I
K
E
L
E
K
R
L
S
E
K
E
E
E
I
Q
E
L
K
R
K
L
H
K
C
Q
---------------------
27
Fugue
39.33
16%
28
- C2 -
4YVQ
-
A:
[1-89]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
E
T
V
P
T
I
K
K
L
R
A
Y
A
E
R
I
R
V
A
E
L
E
K
C
M
S
K
M
GDDIN
K
K
T
T
R
A
V
D
D
L
S
R
G
I
V
N
R
F
L
H
G
P
M
Q
H
L
R
C
R
-
T
L
S
E
T
L
E
N
M
H
A
L
N
R
M
Y
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
38.93
27%
251
- C2 -
2JX6
-
DDSK_PHYDS
A:
[1-33]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
W
S
K
I
K
A
A
G
K
E
A
A
K
------------
A
A
A
K
A
A
G
K
A
A
L
N
A
V
S
E
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
38.67
30%
-97
- C2 -
4LDS
-
?
A:
[41-125]
------------------------------------------------------------
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
-
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
------------
L
I
A
I
V
F
--------------------------
I
I
G
A
L
I
L
A
A
S
T
N
L
A
L
L
I
I
G
R
L
I
-
I
---
G
---
L
A
V
G
--
G
-
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
--------------------------
G
S
L
-
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
A
D
I
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
------------
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
N
A
I
S
E
S
T
W
T
V
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
----
Q
Q
F
--
I
G
I
N
A
V
I
F
Y
---
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
--
I
----
G
M
-
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
-
L
-
W
V
M
-
L
P
E
L
F
-
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
L
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
-----------------------------------
31
Fugue
31.28
13%
193
- C2 -
2JXG
-
?
A:
[1-45]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
T
T
T
L
G
V
K
L
D
D
P
T
R
E
R
L
K
------------
A
A
A
Q
S
I
D
R
T
-----
P
H
W
L
I
K
Q
A
I
F
N
Y
L
E
K
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------