@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT2_HUMAN: (2015-12-08 )
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
Atome Classification :
(20 SA)
.........10----....--....20.......-.30........40......-..50.........60........70........-80.-.......90.---.......100....---.----..-110--.---.......120........130--.........-140.......--.-150.......160.-......170------------------------...-......180.......190.......200.......210.......220.......230.......240.......250.......260.......270----..--.-....280.---......290.......300.......310--........320.......330..--...-...340.......350.......360.......370......-.380.....-...390.......400.......410.......420.......430.......440.......450.......460.......470......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPPMPSAPPVH----PPPD--G
G
W
G
W
I
V
V
G
A
A
F
I
-
S
IGFSYAF
P
K
A
V
T
V
F
F
K
E
I
-
Q
Q
I
-
F
H
T
T
Y
S
E
I
A
W
I
S
S
I
M
L
A
V
M
YAGG
P
V
S
S
V
L
-
V
N
K-YGSR
P
V
V
I
A
G
---
G
L
L
C
C
L
G
M
V
L
A
S
F
S
---
S
----
S
V
-
V
Q
---
L
---
Y
L
T
M
G
F
I
T
-GL
G
L
A
FNL
Q
P
----
A
L
T
I
I
G
K
Y
F
-
Y
-RKRPMANG--L-AMAGS
P
V
F
L
S
SLA
P
-
F
N
Q
Y
L
F
N
--------------------------TFG-WK
G
S
F
L
I
L
G
S
L
L
L
N
A
C
V
A
G
S
L
MRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKK
S
T
W
E
K
V
N
K
Y
L
D
F
S
L
F
KHR
G
F
L
I
Y
LSG
N
V
I
M
F
L
G
F
F
A
P
I
I
F
LAPYA----KD--Q-GI
D
E
Y
S
A
A
---
F
L
L
S
V
M
A
F
V
D
M
FARPSV
G
L
IANS
K
Y
I
R
P
---
R
I
Q
Y
F
F
S
F
A
I
M
F
N
G
V
C
H
L
L
-
C
P
L
--
A
Q
D
-
Y
T
S
L
V
L
Y
A
V
F
F
GL
G
F
G
S
V
S
S
V
L
F
E
T
L
M
D
L
VGAPRFSSAV
G
L
V
-
T
I
V-ECG
P
V
-
L
LGPPLA
G
K
L
V
DLTG
E
Y
K
Y
M
Y
MSC
G
A
I
V
V
A
A
S
V
W
L
L
IGNAI
N
Y
R
L
L
A
K
E
R
K
E
E
N
A
R
QKTRESEPLSKSKHSE
D
V
N
V
K
VSNAQSVTSERETNI
29
Fugue
88.94
10%
-126
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
F
K
P
A
P
H
K
A
R
L
P
AAEI
D
P
T
Y
--
R
R
L
R
W
Q
I
F
L
G
I
F
F
-
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
E
--
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
-
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
-
T
S
SIA
V
---
M
F
V
L
L
F
L
C
-
G
W
F
Q
G
M
G
W
P
P
----
C
G
R
T
M
V
H
W
W
S
Q
-
K
E
R
G
G
I
V
S
--
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
-
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
-----------------
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
----
K
E
--
V
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
---
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
-
W
M
N
--
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------
32
Fugue
85.36
14%
-130
- C1 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------
L
L
L
M
L
V
L
L
V
A
V
G
-
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
-------
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
-
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
-------
L
I
A
A
S
A
M
Q
-
G
M
G
T
G
V
G
G
V
M
----
A
R
T
L
P
R
D
L
Y
-
E
-
R
T
Q
L
R
H
A
N
--
S
-
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
-------------------------
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
---------------
M
G
A
V
---
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
PNK
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
-
M
W
I
--
P
D
W
-
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
-
G
A
L
-
V
G
G
L
Q
-
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------
19
HHSearch
84.31
13%
-111
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[22-419]
-----------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
-
M
K
K
-
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
-
T
L
---
F
---
L
V
-
G
L
F
I
I
-
A
A
G
L
G
C
L
E
T
A
----
A
N
P
F
V
T
V
L
G
-
P
E
S
S
G
H
F
R
L
N
--
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
-
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
L
T
-
K
F
P
A
L
Q
S
D
N
H
-
S
D
A
-------------
K
Q
G
S
F
S
A
S
-----
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
----
V
E
E
I
P
-
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
---
V
-
L
-
A
A
--
Y
A
L
I
A
M
A
L
C
L
I
-
S
A
F
--
A
G
G
-
H
V
G
-
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
-
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
---------------------------------------------------
20
HHSearch
82.45
12%
-118
- C1 -
3WDO
-
?
A:
[30-375]
-----------------------------------------------
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
-
S
D
R
-
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
---
I
---
I
L
-
G
R
A
L
Q
-
G
S
G
A
--
I
A
A
A
----
V
M
A
L
L
S
D
L
T
-
R
E
Q
N
R
T
K
A
M
A
--
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
-
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
-
R
--
E
---------------
S
G
M
V
K
G
S
F
-----
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
----
A
D
--
A
-
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
--
K
Q
-----
V
F
V
F
--
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
--
Q
T
Q
-
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
-
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
18
HHSearch
80.18
10%
-120
- C1 -
1PW4
-
GLPT_ECOLI
A:
[18-429]
---------
E
I
----
D
P
T
Y
--
R
R
L
R
W
Q
I
F
L
G
I
F
F
-
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
-
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
-
A
V
---
M
---
F
V
-
L
L
F
L
C
-
G
W
F
Q
G
M
G
W
P
P
----
C
G
R
T
M
V
H
W
W
-
S
Q
K
E
R
G
G
I
V
S
--
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
-
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
-----------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
----
K
E
V-
K
-
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
---
R
G
A
T
G
V
F
-
F
M
T
L
V
T
I
A
T
I
V
-
Y
W
M
NP
A
G
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------
30
Fugue
77.78
10%
-113
- C1 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
K
N
-----------------
T
N
F
W
M
F
G
L
F
F
F
-
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
--
L
-
H
D
I
-
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
-
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
-
P
L
---
L
Q
YN
I
L
V
G
S
I
V
G
-
G
I
Y
L
G
F
C
F
N
A
----
G
A
P
A
V
E
A
F
I
-
E
-
K
V
S
R
R
S
N
F
EF
G
-
R
A
R
M
F
G
C
V
G
W
A
L
G
A
-
S
I
V
G
I
M
F
--------------------------
T
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
-----------------
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
----
T
S
--
F
-
F
A
T
G
E
Q
G
T
---
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
---
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
-
S
S
F
--
A
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
-
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
--------
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------
21
HHSearch
73.60
15%
-94
- C1 -
2GFP
-
EMRD_ECOLI
A:
[25-360]
--------------------------------------------
T
I
Y
I
P
A
I
A
D
M
-
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
-
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
---
L
---
I
A
-
A
S
A
M
Q
-
G
M
G
T
G
V
G
G
V
M
----
A
R
T
L
P
R
D
L
Y
-
E
R
T
Q
L
R
H
A
N
S
--
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
-
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
---
V
D
A
P
R
T
-----------------
R
L
L
T
S
Y
-----
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
----
G
A
V
-
L
-
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
-----
M
W
Q
S
V
I
-
C
C
L
L
A
G
L
L
M
W
I
-
P
D
W
F
G
V
M
N
-
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
-
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------------------------------------------
22
HHSearch
71.63
13%
-118
- C1 -
2CFQ
-
LACY_ECOLI
A:
[25-390]
---------------------------------------------
A
Y
F
P
F
F
P
I
W
-
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
-
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
Y
N
---
I
---
L
V
-
G
S
I
V
G
-
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
---
R
R
S
N
F
E
F
G
--
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
-
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
-
T
V
A
N
A
V
G
-----------
A
--
N
-
H
S
A
F
S
L
K
--
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
--
G
-
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
-----
A
L
L
L
--
A
G
T
I
M
S
V
R
I
I
G
-
S
S
F
--
A
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
-
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------
23
HHSearch
65.15
14%
-148
- C1 -
3WDO
-
?
A:
[21-175]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
----
M
A
L-
Q
-
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
-----
L
I
V
G
--
G
L
A
V
F
A
A
G
S
V
I
-
A
A
L
--
S
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
-
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
17
PsiBlast_PDB
53.60
25%
-77
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[273-377]
----------------------
G
V
G
V
I
V
I
G
V
-
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-
F
K
T
-
L
G
A
S
-
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
-
F
G
R
K
P
L
Q
I
I
G
---
A
----
L
G
M
A
I
G
M
F
S
---
L
----
G
T
-
A
F
---
Y
---
T
Q
A
P
G
I
V
A
-
L
L
S
M
L
F
Y
V
A
A
----
F
A
M
S
W
G
P
V
C
-
W
-
V
L
L
S
E
I
F
P
--
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
Y
F
V
--------------------------
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
53.41
13%
-98
- C1 -
2CFQ
-
LACY_ECOLI
A:
[257-391]
--------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
-
I
N
R
-
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
I
-
L
K
T
L
H
-
M
F
E
V
P
F
L
L
V
G
----
C
F
K
Y
I
T
S
Q
F
-
E
V
R
F
S
A
T
I
Y
L
--
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
-
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
52.53
17%
-126
- C1 -
2GFP
-
EMRD_ECOLI
A:
[27-170]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
P
A
I
A
D
M
A
----
R
D
--
L
-
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
-----
V
I
L
V
--
G
M
S
I
F
M
L
A
T
L
V
-
A
V
T
--
T
S
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
-
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
15
PsiBlast_PDB
48.81
25%
-60
- C1 -
4GBZ
2
XYLE_ECOLI
A:
[274-378]
----------------------
G
V
G
V
I
V
I
G
V
-
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-
F
K
T
-
L
G
A
S
-
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
-
F
G
R
K
P
L
Q
I
I
G
---
A
----
L
G
M
A
I
G
M
F
S
---
L
----
G
T
-
A
F
---
Y
---
T
Q
A
P
G
I
V
A
-
L
L
S
M
L
F
Y
V
A
A
----
F
A
M
S
W
G
P
V
C
-
W
-
V
L
L
S
E
I
F
P
--
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
Y
F
V
--------------------------
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.75
25%
-64
- C1 -
4GBY
2
XYLE_ECOLI
A:
[274-378]
----------------------
G
V
G
V
I
V
I
G
V
-
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-
F
K
T
-
L
G
A
S
-
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
-
F
G
R
K
P
L
Q
I
I
G
---
A
----
L
G
M
A
I
G
M
F
S
---
L
----
G
T
-
A
F
---
Y
---
T
Q
A
P
G
I
V
A
-
L
L
S
M
L
F
Y
V
A
A
----
F
A
M
S
W
G
P
V
C
-
W
-
V
L
L
S
E
I
F
P
--
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
Y
F
V
--------------------------
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.39
25%
-59
- C1 -
4GC0
2
XYLE_ECOLI
A:
[274-378]
----------------------
G
V
G
V
I
V
I
G
V
-
M
L
-
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-
F
K
T
-
L
G
A
S
-
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
-
F
G
R
K
P
L
Q
I
I
G
---
A
----
L
G
M
A
I
G
M
F
S
---
L
----
G
T
-
A
F
---
Y
---
T
Q
A
P
G
I
V
A
-
L
L
S
M
L
F
Y
V
A
A
----
F
A
M
S
W
G
P
V
C
-
W
-
V
L
L
S
E
I
F
P
--
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
Y
F
V
--------------------------
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.59
28%
-58
- C1 -
4HRV
-
?
A:
[20-97]
-------
P
P
L
N
----
E
S
P
D
VN
G
T
W
G
M
L
A
S
T
A
A
P
L
-
S
E
A
G
Y
Y
V
F
P
A
A
--
V
V
E
E
T
F
-
K
Q
N
-
G
M
T
N
A
A
D
I
H
A
V
R
P
E
K
L
H
Q
I
F
G
N
D
A
V
L
Y
I
T
-
V
T
E
-
Y
G
T
V
T
T
V
S
A
K
---
A
R
L
V
D
S
R
N
G
K
E
L
W
S
---
G
----
S
A
-
S
I
---
R
---
E
G
S
N
N
S
N
S
-
G
L
L
G
M
L
V
S
A
V
----
V
N
Q
I
A
N
S
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.89
30%
-149
- C1 -
4IKY
5
?
A:
[69-148]
---------------------------------------------------------------------
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
-
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
-
A
A
---
L
---
F
V
S
M
A
L
I
V
L
G
T
G
L
---
L
K
P
----
N
V
S
S
I
V
G
D
M
-
Y
-
K
P
G
D
D
R
R
D
--
A
-
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
-
L
A
P
L
V
V
G
--------------------------
T
A
G
-
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
----
R
S
--
P
-
K
T
T
A
E
E
R
S
---
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
Q
Q
G
S
T
I
L
A
N
---
Y
A
D
K
R
T
Q
L
D
V
A
G
I
H
L
S
P
A
W
-
F
Q
S
--
L
N
P
-
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
-
L
V
P
-
G
H
L
S
G
-
G
G
L
V
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
9
PsiBlast_PDB
46.59
30%
-144
- C1 -
4IKW
5
?
A:
[69-148]
---------------------------------------------------------------------
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
-
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
-
A
A
---
L
---
F
V
S
M
A
L
I
V
L
G
T
G
L
---
L
K
P
----
N
V
S
S
I
V
G
D
M
-
Y
-
K
P
G
D
D
R
R
D
--
A
-
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
-
L
A
P
L
V
V
G
--------------------------
T
A
G
-
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
----
R
S
--
P
-
K
T
T
A
E
E
R
S
---
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
Q
G
S
T
I
L
A
N
---
Y
A
D
K
R
T
Q
L
D
V
A
G
I
H
L
S
P
A
W
-
F
Q
S
--
L
N
P
-
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
-
L
V
P
-
G
H
L
S
G
-
G
G
L
V
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
8
PsiBlast_PDB
45.36
30%
-144
- C1 -
4IKV
2
?
A:
[69-148]
---------------------------------------------------------------------
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
-
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
-
A
A
---
L
---
F
V
S
M
A
L
I
V
L
G
T
G
L
---
L
K
P
----
N
V
S
S
I
V
G
D
M
-
Y
-
K
P
G
D
D
R
R
D
--
A
-
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
-
L
A
P
L
V
V
G
--------------------------
T
A
G
-
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
----
R
S
--
P
-
K
T
T
A
E
E
R
S
---
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
Q
G
S
T
I
L
A
N
---
Y
A
D
K
R
T
Q
L
D
V
A
G
I
H
L
S
P
A
W
-
F
Q
S
--
L
N
P
-
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
-
L
V
P
-
G
H
L
S
G
-
G
G
L
V
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
10
PsiBlast_PDB
44.63
30%
-140
- C1 -
4IKX
1
?
A:
[69-148]
---------------------------------------------------------------------
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
-
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
-
A
A
---
L
---
F
V
S
M
A
L
I
V
L
G
T
G
L
---
L
K
P
----
N
V
S
S
I
V
G
D
M
-
Y
-
K
P
G
D
D
R
R
D
--
A
-
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
-
L
A
P
L
V
V
G
--------------------------
T
A
G
-
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
----
R
S
--
P
-
K
T
T
A
E
E
R
S
---
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
Q
Q
G
S
T
I
L
A
N
---
Y
A
D
K
R
T
Q
L
D
V
I
H
L
S
P
A
W
F
Q
-
S
L
N
--
P
L
F
-
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
L
V
-
P
G
H
-
L
G
G
L
V
-
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G