@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT4_HUMAN: (2015-12-08 )
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Atome Classification :
(20 SA)
--.........10........20----.....-....30........40........50-.---.......60........70........80...-.....90...---.....100.....---.---.----110..---......120.......----130.......140--.....-..150........160--.......170--------------------------...-....180........190.....----..200....----..-.-210--.----.....---.--.220.......230.......240.......250-...----....260..---.....270.......280....-...290.......300..-------.....310..-.--.---....320---.......330.......340.......------350.......-360.......-.370.......380.......390.......400.......410.......420.......430.......440.......450.......460...--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MGGAVVDEGPTGVKAPDGG
W
-----
G
W
A
V
L
-
F
G
C
F
V
I
TGF
S
Y
A
F
P
K
A
V
S
V
F
F
K
E
L
I
Q
-
E
---FGIGYS
D
T
A
W
I
S
S
I
L
L
A
M
L
YGTG
P
L
C
S
V
C
V
N
R-FGC
R
P
V
M
L
V
G
---
G
L
F
A
S
L
G
M
V
A
A
S
F
---
C
---
R
----
S
I
-
I
Q
---
V
Y
L
T
T
G
V
I
T
G
L
G
L
A
LN----FQ
P
S
L
I
M
L
N
R
Y
F
S
--KRRPM-ANGL-AAAGS
P
V
F
L
C
A
--
L
S
P
L
G
Q
L
L
Q
D
--------------------------RYG-WR
G
G
F
-
L
I
L
G
G
L
L
L
N
C
C
V
C
A
A
L
M----R
P
L
V
V
TAQP----GS-G-PP---R----PS
R
R
L
---
L
--
D
L
SVFRDR
G
F
V
L
Y
A
V
A
A
S
V
M
V
L
G
LFV
P
P
V
F
V
V
S
Y
-
A
K
D----LGVP
D
T
K
A
A
---
F
L
L
T
I
L
G
F
I
D
I
FARP
A
A
G
F
V
A
G-LGKV
R
P
Y
S
V
Y
L
F
S
F
S
M
F
F
-------
N
G
L
A
D
L
-AGS-T--A---GDYG
G
L
V
---
V
F
C
I
F
F
G
I
S
Y
G
M
V
G
A
L
Q
F
E
V
L
M
A
I
V
G
T------
H
K
F
S
S
A
I
G
L
V
-
L
-
L
M
E
A
V
A
V
L
-
V
GPPSG
G
K
L
L
D
A
T
H
V
Y
M
Y
V
F
I
LA
G
A
E
V
L
T
S
S
L
I
L
L
L
GN
F
F
C
IRKKPKEPQPEVAAA
E
E
E
KLHKPPADSGV
D
L
R
E
V
E
H
F
L
KAEPEKNG
E
V
V
HTPETSV--------------------
14
Fugue
86.53
18%
-105
- C3 -
4IKW
13
?
A:
[3-494]
------
S
I
D
K
Q
Q
I
A
A
S
V
P
Q
R
G
F
FGHPK
G
L
F
T
L
-
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
M
Y
Y
E
V
-
S
KGG
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
---
P
---
G
----
G
V
-
A
A
---
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
----
P
N
V
S
S
I
V
G
D
M
Y
K
P
GD
D
R
R
D
A
-
G
F
S
I
-
F
Y
M
G
I
N
L
G
A
F
L
--
A
P
L
V
V
G
T
A
G
M
--------------------------
K
Y
N
-
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
----
K
K
N
L
G
L
A
G
T
----
Y
V
-
P
-
N
P
---
L
----
T
P
A
E
K
---
K
--
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
--------
V
E
T
----
F
I
S
L
V
G
I
L
G
---
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
P
K
T
T
-
A
E
E
-
R
S
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
Q
G
S
T
I
L
A
N
Y
-
A
D
K
R
T
--
Q
---
L
D
V
A
G
I
H
L
S
P
A
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
K
RQPT
I
P
Q
K
F
A
L
G
L
L
F
A
-
G
-
L
S
F
I
V
I
L
V
-
P
G
H
L
S
G
G
G
L
V
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
---------
P
A
A
F
S
A
Q
T
M
S
L
W
F
L
-
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
MKG
11
Fugue
68.79
12%
-133
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
FK
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
-----
R
W
Q
I
F
-
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
---
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
----
W
A
-
T
S
SIA
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q-
K
E
R
G
G
-
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
--
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
MRDT
P
Q
S
C
G
L
P
P
I
----
E
E
-
Y
-
K
N
---
D
----
T
A
K
Q
I
---
F
--
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
----
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
-------
I
A
T
I
V
Y
-
W
M
N
-
P
--
A
---
G
N
P
T
V
D
M
---
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
------
K
A
A
G
T
A
A
G
F
T
-
G
-
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
-----
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------
21
HHSearch
66.78
14%
-132
- C3 -
1PW4
-
GLPT_ECOLI
A:
[15-432]
----------
P
A
A
E
I
D
P
T
Y
R
R
L
-----
R
W
Q
I
F
-
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
---
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
W
A
T
S
S
I
-
A
V
---
M
F
V
L
-
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q-
K
E
R
G
G
-
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
--
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
----
M
R
D
T
P
Q
S
C
G
LPPI
E
E
Y
K
-
N
D
-------------TAK
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
-
L
K
E
V---
K
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
-
K
V
F
R
G
N
R
G
A
T
G
V
F
-
F
M
T
L
-------
V
T
I
A
T
I
-
V
Y
W
-
M
NP
A
---
G
N
P
T
V
D
M
---
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
------
K
A
A
G
T
A
A
G
F
T
-
G
-
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------
20
Fugue
66.47
14%
-112
- C3 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-----------------
L
L
L
M
L
-----
V
L
L
V
A
-
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
--------
R
-
D
---
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
L
-
T
V
----
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
--
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
L
--
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
-
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
----
M
P
E
T
R
P
V
D
A
----
P
R
-
T
-
R
L
---
L
----
T
S
Y
K
---------
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
-------------
M
G
A
V
---
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
-
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
-------
V
I
C
C
L
L
-
A
G
L
-
L
--
M
---------------------------------
W
I
P
D
W
F
G
------
V
M
N
V
W
T
L
L
V
P
-
A
-
A
L
F
F
F
G
A
G
-
M
L
F
P
L
A
T
S
G
A
M
E
----
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
------
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------------------------
22
HHSearch
64.39
15%
-125
- C3 -
3WDO
-
?
A:
[26-382]
----------------------------------------------
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
---
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
-
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
---
S
---
D
----
S
I
-
W
G
---
I
I
L
G
-
R
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E-
Q
N
R
T
K
-
A
M
A
F
-
I
G
V
S
F
G
I
T
F
A
I
--
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
A
L
F
-
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
----
V
P
N
S
S
T
H
V
L
----
N
R
----
E
---
S
----
G
M
V
K
G
---
S
--
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
-
L
A
D
----
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
-
K
M
K
--
Q
--
V
F
V
F
--
C
V
G
L
-------
I
V
V
A
E
I
V
L
W
N
-
A
--
Q
---
T
Q
F
W
Q
L
V
---
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
------
G
Y
K
G
T
A
M
G
V
Y
-
S
-
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
--------------------
12
Fugue
62.74
10%
-119
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
--------------
M
Y
Y
L
K
N
T
N
-----
F
W
M
F
G
-
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
-------
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
-
Q
Y
---
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
----
F
N
A
G
A
P
A
V
E
A
F
I
E
--
K
V
S
R
R
-
S
N
F
E
-
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
--------------------------
T
I
N
-
N
Q
F
V
F
-
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
----
K
T
D
A
P
S
S
A
T
----
V
A
-
N
-
A
V
---
G
ANHS
A
F
S
L
K
---
L
--
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
-
F
T
S
----
F
F
A
T
G
E
Q
G
T
---
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
-
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
-------
M
S
V
R
I
I
-
G
S
S
-
F
--
A
---
T
S
A
L
E
V
V
---
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
------
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
----
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------
24
HHSearch
58.58
16%
-110
- C3 -
2GFP
-
EMRD_ECOLI
A:
[19-360]
-----------------------------------------
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
-
D
---
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
L
-
T
V
---
L
I
A
A
-
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
-
T
Q
L
R
H
-
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
L
--
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
-
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
----
M
P
E
T
R
P
V
D
A
----
P
---------
R
----
T
R
L
L
T
---
S
--
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
-
M
G
A
V
---
L
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
-
R
F
S
T
L
M
W
-
Q
S
V
I
--
C
C
L
L
-------
A
G
L
L
M
W
-
I
P
D
-
W
F
G
V
---
M
N
V
W
T
L
L
---
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-------
F
L
A
G
T
A
G
A
L
V
-
G
-
G
L
Q
N
I
G
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------
25
HHSearch
58.30
12%
-124
- C3 -
2CFQ
-
LACY_ECOLI
A:
[21-397]
--------------------------------------------
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
-
D
I--
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
---
G
---
P
----
L
L
Q
Y
N
---
I
L
V
G
-
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
---
R
R
S
N
F
-
E
F
G
R
-
A
R
M
F
G
C
V
G
W
A
L
--
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
F
V
F
-
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
----
K
T
D
A
P
S
S
A
T
----
V
A
-
N
A
V
G
AN
H
S
----
A
F
S
L
K
---
L
--
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
-
F
T
S
F
FAT
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
-
R
I
G
G
K
N
--
A
L
L
L
--
A
G
T
I
-------
M
S
V
R
I
I
-
G
S
S
-
F
--
A
---
T
S
A
L
E
V
V
---
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
------
R
F
S
A
T
I
Y
L
V
C
F
C
-
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------
23
HHSearch
58.19
12%
-130
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-421]
---------------------
R
-----
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
-
A
---
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
-
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
---
A
A
E
I
M
----
N
Y
-
T
L
---
F
L
V
G
-
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E-
S
S
G
H
F
-
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
I
--
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
-
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
---
F
P
A
L
Q
S
D
N
-----
H
S
-
D
-
A
K
---
Q
----
G
S
F
S
A
---
S
--
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
-
A
V
E
E
I--
P
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
-
R
F
A
P
H
K
V
--
L
A
A
--
Y
A
L
I
-------
A
M
A
L
C
L
-
I
S
A
-
F
--
A
---
G
G
H
V
G
-
L
---
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
------
D
T
K
-
Y
G
S
S
F
I
---
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------
27
HHSearch
45.19
17%
-138
- C3 -
2GFP
-
EMRD_ECOLI
A:
[21-173]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
D
----
L
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
-
R
V
G
R
R
P
--
V
I
L
V
--
G
M
S
I
-------
F
M
L
A
T
L
-
V
A
V
-
T
--
T
---
S
S
L
T
V
L
I
---
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
------
T
Q
L
R
H
A
N
S
L
L
-
N
-
M
G
I
L
V
S
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
--------------------
1
PsiBlast_PDB
44.92
28%
-94
- C2 -
1EVY
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
44.82
14%
-111
- C3 -
2CFQ
-
LACY_ECOLI
A:
[256-396]
------------------------------------------------------------------
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
-
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
---
A
---
T
----
S
A
-
L
E
---
V
V
I
L
-
K
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V-
R
F
S
A
T
-
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
--
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
-
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
----
L
S
G
P
G
P
L
S
L
----
L
R
-
R
-
Q
V
---
N
----
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.82
28%
-104
- C2 -
1N1E
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
T
--
S
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
-
V
Y
K
----
K
K
N
P
R
D
A
L
A
---
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
44.51
28%
-98
- C2 -
1M67
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
44.47
28%
-100
- C2 -
1N1G
2
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
44.41
28%
-100
- C2 -
1JDJ
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
44.17
11%
-128
* C3 *
3WDO
-
?
A:
[11-179]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
-
G
M
A
L---
Q
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
-
R
I
G
R
K
P
--
L
I
V
G
--
G
L
A
V
-------
F
A
A
G
S
V
-
I
A
A
-
L
--
S
---
D
S
I
W
G
I
I
---
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
------
Q
N
R
T
K
A
M
A
F
I
-
G
-
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
--------------------
2
PsiBlast_PDB
43.77
28%
-98
- C2 -
1EVZ
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.91
28%
-98
- C2 -
1M66
1
GPDA_LEIME
A:
[200-287]
------------------------------------------------------------------------------------------------------------------
T
V
G
C
E
V
A
S
A
---
V
---
K
----
N
V
-
L
A
---
I
--
G
S
G
V
A
N
G
L
G
M
G
L
N
----
A
R
A
A
L
I
M
--
R
G
L
L
--
E
I
R
D
L
-
T
A
A
L
-
G
G
D
G
S
A
V
F
------------------------------------------------
G
L
-
A
G
L
G
D
L
Q
L
T
C
--
S
S
E
L
S
----
R
N
F
T
V
G
K
K
L
----
G
K
-
G
-
L
P
---
I
----
E
E
I
Q
R
---
A
--
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
-
K
K
N
----
P
R
D
A
L
A
D
L
L
---
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
37.49
9%
-136
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[36-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
----
F
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
-
K
L
S
Y
K
A
--
G
I
I
T
--
G
L
F
L
-------
Y
A
L
G
A
A
-
L
F
W
-
P
--
A
A
E
I
M
N
Y
T
L
F
L
---
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
------
S
S
G
H
F
R
L
N
L
A
-
Q
-
T
F
N
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
--------------------