@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT5_HUMAN: (2015-12-08 )
MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT
Atome Classification :
(20 SA)
--------------------------.........10---........--20........30......-..40.......-.50-...---.....60........70........80.-.......90.---..----.....100.....---.----.110-...-.---.....120.......130--.........140-.-.-....---...150........160...-.-...170........180------.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290........300.......310----...----.....320...-....330.......340.......350.......360-.......370---.......380-.....---.---.----..-------390.......400.......410.......420.......430.....-...-440.......450.......460.......470.......480.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------MLKREGKVQPY---TKTLDGGW--
G
W
M
I
V
I
H
F
F
L
V
N
V
F
V
M
GM-T
K
T
F
A
I
F
F
V
V
F
-
Q
E
E
-FEG---
T
S
E
Q
I
G
W
I
G
S
I
M
S
S
L
R
F
CA
G
P
L
V
A
I
I
C
D
-
I
LG
E
K
T
T
S
I
L
---
G
A
----
F
V
VTG
G
Y
L
I
S
S
W
A
---T----S
I
---
P
F
L
-
C
---
V
T
M
G
LLPG
L
G
S
A
F
L
Y
Q
----
V
A
A
V
V
T
T
K
Y
F
---
K
-
K
-
R
L
A
L
---
S
T
A
I
A
-RSGM
G
L
T
F
L
L
A
P
F
T
-
K
-
F
L
I
D
-
L
YDWT
G
A
L
I
L
F
G
------
A
I
A
L
N
LV
P
S
S
M
L
L
R
P
I
H
I
KSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKN
L
T
VSQNQ
S
E
E
FYNGPNR
N
R
L
L
L
KSDEESD
K
V
I
S
W
S
C
K
Q
L
F
-
D
I
S
LFRN
P
F
F
Y
I
F
T
W
S
F
L
L
S
-----
Q
L
A
----
Y
F
I
P
T
F
H
L
V
AR-
A
K
T
L
G
I
D
IM
D
A
S
Y
L
V
S
V
A
G
I
L
E
T
V
S
Q
I
I
S
G
W
VA
D
Q
N
W
-
I
K
K
Y
HYH
K
S
Y
---
L
I
L
C
G
I
T
N
---
L
L
A
P
L
---
A
---
T
----
T
F
-------
P
L
L
M
T
Y
T
I
C
F
A
I
FAG
G
Y
L
A
L
I
L
P
V
L
V
D
L
CRNS
T
V
N
R
F
L
G
L
A
-
S
F
F
A
G
M
-
A
VL-SGPPI
A
G
W
L
Y
D
Y
T
QTYNG
S
F
Y
F
S
G
I
C
Y
L
L
S
S
V
S
F
F
F
V
P
L
A
E
R
W
K
NSLT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
80.80
19%
-121
- C2 -
4M8O
5
DPOE_YEAST
A:
[31-1186]
A
L
S
A
Q
Q
L
L
N
A
S
K
I
D
D
I
D
S
M
M
GF
E
R
Y
V
P
P
Q
Y
N
G
R
F
D
A
K
D--
I
D
Q
I
P
G
R
V
--
G
W
L
T
N
M
H
A
T
L
V
S
Q
E
V
T
T
N
-
Q
G
I
S
G
V
D
F
Y
F
L
-
D
E
E
-
G
-------------
G
S
F
K
S
T
V
V
Y
--
D
P
Y
F
F
I
A
C
N
----------------------------------------------------------------
D
E
S
R
V
N
----
D
V
E
E
L
V
K
K
Y
L
---
E
-
S
-
C
L
K
S
---
L
Q
I
I
R
-
K
E
D
L
T
M
D
N
H
L
L
G
L
Q
-
K
-
T
L
I
K
-
L
S
F
V
N
---------------
S
N
Q
L
F
E
A
R
K
L
L
R
P
I
L
Q
D
N
A
N
N
N
V
Q
R
N
I
---
Y
N
V
K
V
D
A
K
H
L
I
E
D
I
R
E
--------------------------------
Y
D
V
P
Y
H
V
R
V
S
I
D
K
D
I
R
V
G
K
W
Y
K
V
T
Q
Q
G
F
I
E
D
T
R
K
I
A
F
A
D
P
V
V
M
A
F
A
I
A
T
T
-----
K
P
P
----
L
K
F
P
D
S
A
V
D
---------
Q
I
M
M
I
S
Y
M
I
D
G
E
G
F
L
I
T
N
R
E
I
I
S
E
D
I
E
D
F
E
Y
-
T
P
K
P
E
Y
-
P
G
F
---
F
T
I
F
N
E
N
D
---
E
V
A
L
L
---
Q
---
R
----
F
F
-------
E
H
I
R
D
V
R
P
T
V
I
S
T
F
N
G
D
F
-
F
D
W
P
F
I
H
N
R
S
K
I
H
G
L
D
M
F
D
E
I
-------------------
G
F
A
P
D
A
E
G
E
Y
K
S
S
Y
C
S
H
M
D
C
F
R
W
V
K
R
D
S
Y
L
-
P
Q
G
S
Q
G
L
K
A
V
T
Q
S
K
LGYN
P
I
E
L
D
PEL
M
T
P
Y
A
F
EK
P
Q
H
L
S
E
Y
S
V
S
D
A
V
A
T
Y
Y
L
Y
M
K
Y
V
H
P
F
I
F
S
L
C
T
I
IPLN
P
D
E
T
L
R
KG
T
G
T
L
C
E
M
L
L
M
V
Q
A
Y
Q
H
N
I
L
L
P
N
K
HTDPI
E
R
F
Y
DGHLLE
S
E
T
Y
V
G
G
H
V
E
S
L
E
A
G
V
F
R
SD
L
K
N
E
F
K
I
D
P
S
A
I
D
E
L
L
Q
E
L
P
E
A
L
K
F
S
V
E
VENKSSVDKVTN
F
E
E
I
K
N
Q
I
T
Q
K
L
L
E
L
K
E
N
NI
R
N
E
L
P
L
I
Y
H
V
D
V
ASM
Y
P
N
I
M
T
T
N
RLQPDSIKAERDCASCTC
A
R
K
L
K
W
A
W
R
G
E
F
F
PSK
M
D
E
Y
N
M
I
K
R
A
L
Q
N
E
T
F
P
NKNKFSKKKVLTFDELS
Y
A
D
Q
V
I
H
I
K
K
R
L
T
E
Y
S
R
K
VYHRV
K
V
S
E
I
V
E
R
E
A
I
V
C
QRENP
F
Y
V
D
T
V
K
S
F
R
D
R
R
Y
E
F
K
G
L
A
K
T
W
K
G
N
L
S
KIDPSDKHAR
D
E
A
K
K
M
I
V
L
Y
D
S
L
Q
L
A
H
K
V
I
L
N
S
F
Y
G
YVMRKGSRWYS
M
E
M
A
G
I
T
C
L
T
G
A
T
I
I
Q
M
A
R
A
L
V
E
R
V
G
R
P
L
E
LDTD
G
I
W
C
I
L
PKSFP
E
T
Y
F
F
T
L
ENG
K
K
L
Y
L
S
Y
P
C
S
M
L
N
Y
R
V
H
Q
K
FTNHQYQELKDPLNY
I
Y
E
T
H
S
E
N
T
I
F
F
E
V
D
G
PYK
A
M
I
L
P
S
S
KEEG
K
G
I
K
K
R
Y
A
V
F
N
EDGSLAELKGFELKRRGEL
Q
L
I
K
N
F
Q
S
D
I
FKVFLEGDT
L
E
G
C
Y
S
A
V
A
S
V
C
N
R
W
L
D
V
L
D
S
HGLMLE
D
E
D
L
V
S
L
I
C
E
N
R
S
MSKTLKEYEGQKS
T
S
I
T
T
A
R
R
L
G
D
F
LGEDMVKDKG
L
Q
C
K
Y
I
I
S
SKPFNAPVTERAIPVAIFSAD
I
P
I
K
R
S
F
L
R
R
W
T
LDPSLEDLDIRTIID
W
G
Y
Y
R
E
R
L
G
S
A
I
Q
K
I
IT
I
P
A
A
L
Q
GVSNPVPRVEHP
D
W
L
K
R
K
I
AT
22
Fugue
77.84
11%
-102
- C3 -
4IKW
13
?
A:
[3-494]
--------------------------
S
I
D
K
Q
Q
I
A
A
S
V
---
P
Q
R
G
F
F
G
H
PK
G
L
F
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
-
M
R
A
I
L
V
Y
Y
M
Y
Y
-
E
V
S
-
K
G
G
LGL
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
---
G
G
----
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
---
A
A
L
-
F
---
V
S
M
A
L
I
V
-
L
G
T
G
L
L
K
P
----
N
V
S
S
I
V
G
D
M
Y
---
K
-
P
--------
G
D
D
R
R
-
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
-
A
-
F
L
A
P
-
L
V
V
G
T
A
G
M
K
Y
N
F
------
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
P
-
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
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G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
P
K
T
---
T
A
E
E
R
S
-
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
-----
Q
G
S
----
T
I
L
A
N
Y
A
D
K
R
T
-
Q
L
D
V
A
G
I
H
L
S
P
A
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
-
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
---
I
V
I
L
V
---
P
---
G
----
H
L
S
GGGLVH
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
---
L
C
L
S
P
V
G
L
S
A
T
T
K
L
A
P
A
A
F
S
A
Q
T
-
M
S
L
W
F
L
-
S
N
A
-
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
75.87
12%
-127
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--------------------------
F
K
P
A
P
H
K
A
R
L
P
AAE
I
D
P
T
Y
R
R
L
--
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
-
R
K
N
F
A
L
A
M
P
Y
L
-
V
E
Q
--
G
F
---
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
-
R
S
N
P
R
V
F
L
P
A
---
G
L
----
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
T
S
S
I
A
V
-
M
---
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
----
P
C
G
R
T
M
V
H
W
W
SQK
E
-
R
-
G
G
I
V
---
S
V
W
N
C
-
A
H
N
V
G
G
G
I
P
P
L
L
F
L
-
L
-
G
M
A
W
-
F
N
D
W
H
A
A
L
Y
M
P
A
------
F
C
A
I
L
V
A
L
F
A
F
A
M
---------------------------------------------------
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
---------------------
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
-----
Y
L
L
----
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
A
T
G
V
F
---
F
M
T
L
V
T
I
A
---
T
I
V
Y
W
M
NP
A
---
G
----
N
P
-------
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
-
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
QELVP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
75.69
13%
-121
* C3 *
1PW4
-
GLPT_ECOLI
A:
[11-430]
-----------------------------
K
A
R
L
P
A
A
E
---
I
D
P
T
Y
R
R
L
--
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
-
R
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
---
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
-
R
S
N
P
R
V
F
L
P
A
---
G
L
----
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
---
A
V
M
-
F
---
V
L
-
L
F
L
C
G
W
F
Q
G
M
G
W
P
----
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
-
E
R
G
G
---
I
V
S
V
W
-
N
C
A
H
N
V
G
G
G
I
P
P
L
L
-
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
------
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
-
S
----
C
G
L
P
--------
P
I
E
E
Y
K
N
-------
D
----------------------------------------------
T
A
-----
K
Q
I
F
-
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
----
D
W
S
P
T
Y
L
-----
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
--
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
---
N
---
P
AG--
N
P
-------
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
-
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
73.25
10%
-106
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
--------------------------
M
Y
Y
L
K
N
-------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
-
G
A
Y
F
P
F
F
P
I
W
L
-
H
D
I
-
N
H
I
---
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
-
K
L
G
L
R
K
Y
L
L
W
---
I
I
----
T
G
M
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
---
P
L
L
-
Q
YNI
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
----
A
G
A
P
A
V
E
A
F
I
---
E
-
K
-
V
S
R
R
SNF
E
F
G
R
A
-
R
M
F
G
C
V
G
W
A
L
G
A
S
I
-
V
-
G
I
M
F
-
T
I
N
N
Q
F
V
F
W
L
G
S
------
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
-------------------------------------------------------------------
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
-----
V
F
D
----
Q
Q
F
A
N
F
F
-
T
S
F
-
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
---
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
---
I
G
S
S
F
---
A
---
T
----
S
A
-------
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
-
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
71.66
12%
-100
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-435]
-------------------------------------------
R
S
Y
I
I
--
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
-
N
D
I
L
L
P
Q
F
Q
Q
A
-----
F
T
L
---
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
-
K
L
S
------------------------------------------
Y
K
A
-
G
---
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
----
P
A
A
E
I
M
N
--
Y
---
T
-
L
-
F
L
V
G
---
L
F
I
I
A
-
A
G
L
G
C
L
E
T
A
A
N
P
F
V
-
T
-
V
L
G
P
-
E
S
S
G
H
F
R
L
N
L
A
Q
------
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
-----
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
-
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
-----
Y
A
V
----
E
E
I
P
------------
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
--------
F
A
P
H
K
---
V
L
A
A
Y
A
L
I
---
A
M
A
L
C
---
L
---
I
----
S
A
-------
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
-
L
G
Q
D
T
K
Y
G
-
S
S
F
I
V
M
-
T
I
I
-
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
----
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
70.25
18%
-108
- C1 -
4UZ1
1
NOTUM_HUMAN
A:
[9-375]
-----------------------------
N
E
D
---------------------
L
R
L
H
L
L
L
-
N
T
S
V
T
C
N
-
D
G
S
P
A
G
Y
Y
L
K
----
E
-
S
R
G
---
S
R
R
W
L
L
F
L
E
G
G
W
----
Y
C
---
F
N
R
E
N
C
D
-
S
R
Y
D
T
M
R
R
L
M
---
S
S
RDWP
R
T
R
T
G
T
G
I
L
S
S
Q
P
---
E
----
E
N
---
P
Y
W
W
N
---
A
N
M
V
F
I
P
Y
C
S
S
D
--------
V
W
S
G
A
S
S
K
S
E
---
K
-
N
-
E
Y
A
F
------------
M
G
A
L
I
I
Q
E
V
V
R
-
E
-
L
L
G
R
-
G
L
S
G
A
K
V
L
L
L
A
G
S
S
A
G
G
T
G
V
L
L
N
V
D
R
V
A
E
Q
L
E
K
L
G
Y
P
A
I
Q
V
R
G
L
A
D
S
G
W
F
L
D
N
K
----
Q
Y
R
H
T
D
C
V
D
T
I
T
C
---------------
A
P
T
E
A
I
R
R
G
I
R
Y
W
N
G
V
V
P
E
R
C
R
R
Q
F
Q
E
G
E
----
E
W
N
C
F
F
G
Y
-
K
V
Y
P
T
L
R
S
P
V
F
V
V
Q
W
L
F
D
E
A
-----
Q
L
T
V
D
NV
H
L
P
V
Q
E
G
L
R
L
Y
-
I
Q
N
L
G
R
E
L
R
H
T
L
K
D
V
P
A
S
F
A
P
A
C
L
S
H
E
I
----------
I
I
R
S
H
W
T
D
V
Q
---
V
--------------
K
---
G
---
T
----
S
L
-------
P
R
A
L
H
---
C
W
D
R
S
-------
L
H
K
T
P
L
K
G
C
P
V
H
L
V
D
S
C
----------------------
P
W
P
H
C
N
P
S
C
P
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
47.57
18%
-136
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-172]
-----------------------------------------------
R
--
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
---
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
-
K
L
S
Y
K
A
G
I
I
T
---
G
L
----
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
---
T
L
F
-
L
---
V
G
-
L
F
I
I
A
A
G
L
G
C
L
E
T
----
A
A
N
P
F
V
T
V
L
G
---
P
-
E
S
S
G
H
F
---
R
L
N
L
A
-
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
-
G
-
Q
S
L
I
-
L
S
N
V
P
H
Q
S
Q
D
V
L
------
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
A
-
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
-----
I
S
R
----
F
A
P
H
K
V
L
A
A
Y
A
-
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
-
S
L
G
I
K
N
L
G
Q
D
---
T
K
Y
G
S
S
F
I
---
V
M
T
I
I
---
G
---
G
----
G
I
-------
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
46.44
12%
-117
- C3 -
2GFP
-
EMRD_ECOLI
A:
[26-172]
-----------------------------------------------------------------------
I
Y
I
P
A
I
A
D
M
-
A
R
D
-
L
N
V
---
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
-
R
V
G
R
R
P
V
I
L
V
---
G
M
----
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
---
T
V
L
-
I
---
A
A
-
S
A
M
Q
G
M
G
T
G
V
G
G
V
----
M
A
R
T
L
P
R
D
L
Y
---
E
R
T
-
Q
L
R
H
---
A
N
S
L
L
-
N
M
G
I
L
V
S
P
L
L
A
P
L
I
-
G
G
L
L
D
T
-
M
W
N
W
R
A
C
Y
L
F
L
L
------
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
-
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
-----
V
W
T
----
L
L
V
P
A
A
L
F
F
F
G
-
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
-
L
A
S
L
S
A
M
L
P
Q
---
T
G
Q
G
S
L
G
L
---
L
M
T
L
M
---
G
---
L
----
L
I
-------
V
L
C
W
L
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
43.03
14%
-103
- C3 -
3WDO
-
?
A:
[39-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
-
R
K
-
P
-
L
I
V
G
G
---
L
A
V
F
A
A
G
S
---
V
I
A
A
L
---
S
---
D
----
S
I
-------
W
G
I
I
L
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
-
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
-
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
42.90
17%
-102
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[49-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
F
-
Q
Q
A
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
-
Y
K
A
--
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
---
A
L
F
W
P
---
A
A
E
I
M
----
N
Y
-------
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
-
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
41.16
16%
-136
- C3 -
2CFQ
-
LACY_ECOLI
A:
[25-177]
-----------------------------------------------------------------------
A
Y
F
P
F
F
P
I
W
-
L
H
D
I
N
H
I
---
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
-
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
----
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
--
Y
N
I
-
L
---
V
G
-
S
I
V
G
G
I
Y
L
G
F
C
F
N
AG
A
P
A
V
E
A
F
I
E
K
V
S
-----
R
-
R
S
N
F
---
E
F
G
R
A
-
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
-
I
M
F
T
--
I
N
N
Q
F
V
F
W
L
G
S
------
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
-
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
-----
I
G
S
----
S
F
A
T
S
A
L
E
V
V
I
-
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
-
C
F
F
K
Q
L
A
M
I
F
---
M
S
V
L
A
G
N
M
---
Y
E
S
I
G
---
F
---
Q
----
G
A
-------
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
40.18
15%
-114
- C3 -
3WDO
-
?
A:
[31-174]
--------------------------------------------------------------------------
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
---
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
-
R
I
G
R
K
P
L
I
V
G
---
G
L
----
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
---
W
G
I
-
I
---
L
G
-
R
A
L
Q
G
S
G
A
--
I
A
A
----
A
V
M
A
L
L
S
D
L
T
---
R
E
Q
-
N
R
T
K
---
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
I
A
M
V
L
-
G
P
I
I
T
H
-
K
L
G
L
H
A
L
F
W
M
I
A
------
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
-
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
-----
F
W
Q
----
L
V
V
G
V
Q
L
F
F
V
A
-
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
---
G
M
F
D
G
Q
G
V
---
F
L
A
G
A
---
M
---
L
----
A
A
-------
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
-
V
K
E
V
L
I
-
A
E
E
-
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
40.09
14%
-95
- C3 -
1PW4
-
GLPT_ECOLI
A:
[56-200]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
-
P
R
V
-
F
-
L
P
A
G
---
L
I
L
A
A
A
V
M
---
L
F
M
G
F
---
V
---
P
W
A
T
S
S
I
-------
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
H
N
V
-
G
G
G
-
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
38.72
17%
-99
- C3 -
2CFQ
-
LACY_ECOLI
A:
[256-390]
---------------------------------------------------------------------------------------
Q
---
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
-
R
I
G
G
K
N
A
L
L
L
---
A
G
----
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
---
L
E
V
-
V
---
I
L
-
K
T
L
H
M
F
E
V
P
F
L
L
V
----
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
-
F
S
A
T
---
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
-
N
M
Y
E
-
S
I
G
F
Q
G
A
Y
L
V
L
G
------
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
38.57
29%
-85
- C3 -
4IKV
2
?
A:
[23-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
F
---
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
-----
I
L
V
----
Y
Y
M
--
Y
Y
E
V
S
K
-
G
G
-
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
---
L
I
M
A
G
H
I
A
---
L
A
I
P
G
---
G
---
V
----
A
A
-------
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
G
D
D
R
R
D
A
G
F
S
I
F
-
Y
M
G
I
N
L
-
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.50
29%
-85
- C3 -
4IKZ
1
?
A:
[23-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
F
---
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
-----
I
L
V
----
Y
Y
M
--
Y
Y
E
V
S
K
-
G
G
-
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
---
L
I
M
A
G
H
I
A
---
L
A
I
P
G
---
G
---
V
----
A
A
-------
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
G
D
D
R
R
D
A
G
F
S
I
F
-
Y
M
G
I
N
L
-
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
36.74
29%
-82
- C3 -
4IKX
1
?
A:
[23-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
F
---
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
-----
I
L
V
----
Y
Y
M
--
Y
Y
E
V
S
K
-
G
G
-
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
---
L
I
M
A
G
H
I
A
---
L
A
I
P
G
---
G
---
V
----
A
A
-------
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
G
D
D
R
R
D
A
G
F
S
I
F
-
Y
M
G
I
N
L
-
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
36.45
29%
-89
- C3 -
4IKW
5
?
A:
[23-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
F
---
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
-----
I
L
V
----
Y
Y
M
--
Y
Y
E
V
S
K
-
G
G
-
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
---
L
I
M
A
G
H
I
A
---
L
A
I
P
G
---
G
---
V
----
A
A
-------
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
G
D
D
R
R
D
A
G
F
S
I
F
-
Y
M
G
I
N
L
-
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
36.41
29%
-85
- C3 -
4IKY
5
?
A:
[23-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
F
---
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
-----
I
L
V
----
Y
Y
M
--
Y
Y
E
V
S
K
-
G
G
-
L
G
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
Y
G
G
L
---
L
I
M
A
G
H
I
A
---
L
A
I
P
G
---
G
---
V
----
A
A
-------
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
P
G
D
D
R
R
D
A
G
F
S
I
F
-
Y
M
G
I
N
L
-
G
A
F
-
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
T
R
K
K
N
L
G
L
A
G
T
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------