@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT6_HUMAN: (2015-12-08 )
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------.........-10........20...------.....30........40.-..-.....50.........60-------........70--....----..-..80.....---...90........100-.----..-..---.---...110.......120--.........130.---.-...------..140--..-......150.......160..--------------------------...-..170-.......180.......-190-------.......200.......210.......220.-------....-..230.......240.......250.......260----.-.-.-....270..----------.....280.......290.......300......-.310.......320.-..-------.....330---.......340.......350.......360.....--------------..-370.....-..380.......390.-------------......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------MP
Q
A
L
ERAD-GS
W
A
W
V
V
L
L
A
T
M
V
TQ------GLTLG
F
P
T
C
I
G
I
F
F
T
E
L
Q
-
W
E
-
F
QASNS-ETS
W
F
P
S
I
L
T
A
-------
V
L
H
MA
G
P
L
C
S
--
I
L
V
G
----RF-G
C
R
V
T
V
M
L
G
---
G
V
L
A
S
L
G
M
V
A
S
S
F
S---
H
----
N
L
-
S
Q
---
L
---
Y
F
T
A
G
F
I
T
G
L
G
M
C
F
----
S
F
Q
S
S
I
T
V
L
G
F
Y
F
---
V
-
R
R
R
------
V
L
A
N
---
A
L
-
A
S
M
G
V
S
L
G
I
T
L
W
P
L
L
S
R
Y
L
L
E
--------------------------NLG-WR
G
T
F
-
L
V
F
G
G
I
F
L
H
C
C
I
C
G
A
I
I
-
R
P
V
-------
A
TSVAPETKECPPPPPET
P
A
L
G
C
L
A
A
C
G
R
T
I
-------
Q
R
H
L
-
A
F
D
I
L
RHNT
G
Y
C
V
Y
I
L
G
V
M
W
S
V
LGFP
L
P
Q
V
F
L
V
P
Y
----
A
-
M
-W-HSV
D
E
Q
Q
A
A
----------
L
L
I
S
IIGFS
N
I
F
L
R
P
L
A
G
L
MAGR
P
A
F
A
S
H
R
K
Y
L
F
-
S
L
A
L
L
L
N
G
L
T
N
L
V
-C-AA-------SG
D
F
W
V
L
V
---
G
Y
C
L
A
Y
S
V
S
M
S
G
I
G
A
L
I
F
Q
V
L
M
D
IV
P
M
D
Q
F
P
R
A
L
G
--------------
L
F
-
T
V
L
D
G
L
A
F
-
L
ISPPLA
G
L
L
L
DATNN-------------
F
S
Y
V
F
Y
M
S
S
F
F
L
I
S
A
A
L
F
MGG
S
F
Y
A
L
Q
K
K
EQG
K
Q
A
V
A
A
D
A
L
ER
D
L
F
L
E
AKDGPGKQRS
P
E
I
M
CQSSRQPRPAGVNKHLWGCPASSRTSH
E
W
L
LW
P
K
A
V
L
Q
A
K
Q
T
ALGWNSPT
27
HHSearch
83.72
14%
-141
- C2 -
3WDO
-
?
A:
[27-382]
------------------------------------------------------------------------------------------------------------------------
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
-
L
I
G
I
A
I
G
I
Y
G
L
-------
T
Q
A
V
F
Q
I
P
F
G
--
L
L
S
D
----
R
I
-
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
---
I
---
I
L
G
-
R
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
---
R
E
Q
N
R
------
T
K
A
M
---
A
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
A
L
F
-
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
-
V
P
N
-------
S
S
T
H
V
L
N
R
E
S
G
---------------------------
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
----
L
-
A
-
D
-
A
G
F
P
A
A
E
H
W
K
V
Y
-------
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
----
K
Q
--
V
F
-
V
F
C
V
G
L
I
V
V
A
E
I
V
-
L
W
N
A
-------
Q
T
Q
F
W
Q
L
V
---
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
--------------
V
Y
-
S
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
--------------
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------
28
HHSearch
81.80
15%
-140
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[30-421]
-----------------------------------------------------------------------------------------------------
L
L
C
S
L
F
------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
A
-
F
T
L
T
N
F
-
Q
A
G
L
I
Q
S
A
F
Y
F
-------
G
Y
F
I
I
P
I
P
A
G
--
I
L
M
K
----
K
L
-
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
-
T
L
---
F
---
L
V
G
-
L
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
---
P
E
S
S
G
------
H
F
R
L
---
N
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
-
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
-------
L
Q
S
D
--
N
H
S
D
A
K
----
Q
G
--------------------
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
----
A
V
E
-
E
I
P
G
M
T
A
G
F
A
A
----------
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
--
P
H
K
--
V
L
-
A
A
Y
A
L
I
A
M
A
L
C
L
I
-
S
-
A
F
-------
A
G
G
H
V
G
-
L
---
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
--------------
F
I
--
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
-------------
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
---------------------------------------------------------------------------------------
17
Fugue
81.17
11%
-135
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------------------------------------------------------------------------FKPAPHKARL
P
A
A
E
I
D
P
T
Y
-
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
------
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
-
Q
G
F
S
R
G
-
D
L
G
F
A
L
S
G
I
S
I
-------
A
Y
G
F
S
K
F
I
M
G
--
S
V
S
D
----
R
S
-
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
-
T
S
SIA
V
---
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
E
R
------
G
G
I
V
---
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
--------------
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
-------
N
D
T
A
-------
K
Q
I
F
-
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
----
K
-
E
-
V
-
K
H
F
A
L
D
K
S
S
----------
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
-
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
-
N
P
-------
A
G
N
P
T
V
D
M
---
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
--------------
F
T
-
G
L
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-------------
W
----
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------
23
Fugue
78.40
15%
-99
- C1 -
4WIS
-
?
A:
[19-719]
GVDFVIH
Y
K
V
P
A
A
E
R
D
E
A
E
A
G
F
V
Q
L
I
R
A
L
T
T
V
G
L
A
T
E
V
R
H
G
E
NE
S
L
L
V
F
V
K
V
A
S
P
D
L
F
A
K
Q
V
Y
R
A
R
L
G
D
W
L
H
GVRVSAPHND
I
A
Q
A
L
Q
D
E
P
V
V
E
A
E
R
L
R
L
I
Y
L
M
I
T
K
PHNEWK
H
V
E
S
I
F
P
L
H
S
H
S
F
N
K
E
W
I
-
K
K
-
W
S
S
K
Y
T
L
E
Q
T
D
I
D
N
I
R
D
K
FG
E
S
V
A
F
Y
F
A
F
L
R
S
Y
F
R
F
L
V
I
P
S
----
A
F
-
G
F
G
A
W
L
L
L
G
---
Q
F
S
Y
L
Y
A
L
L
C
G
L
W
S
---
V
----
V
F
-
F
E
---
Y
---
W
K
K
Q
E
V
D
L
A
V
Q
W
G
V
----
R
G
V
S
S
I
Q
Q
S
R
P
E
F
---
E
-
W
E
H
------
E
A
E
D
---
P
I
-
T
G
E
P
V
K
V
Y
-
P
P
M
K
R
V
K
T
Q
L
L
Q
--------------------------
I
P
F
-
A
L
A
C
V
-
V
A
L
G
A
L
I
V
T
C
N
S
L
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V
F
I
-
N
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V
YSGPG
K
Q
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L
G
F
L
P
T
I
F
L
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M
G
A
A
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A
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NYAT
V
D
A
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D
A
-
A
L
I
Q
K
Q
F
V
L
N
F
M
T
S
Y
M
A
L
F
F
T
A
F
V
Y
I
P
F
G
H
I
L
H
P
F
----
L
-
N
-
F
-
W
R
A
T
A
Q
T
L
T
FSEKELPTRE
F
Q
I
N
P
A
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I
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Q
M
F
Y
F
T
V
T
A
Q
I
V
N
F
A
T
E
V
V
V
P
Y
I
K
-
Q
Q
A
F
Q
A
E
F
L
Q
R
V
R
-
E
-
E
C
T
LEEYD
V
S
G
D
Y
R
E
M
V
M
Q
F
G
Y
V
A
M
F
S
V
A
W
P
L
A
A
C
C
F
L
V
N
N
W
V
E
L
R
S
D
A
L
K
I
A
I
S
SRRPI
P
W
R
T
DSIG
P
W
L
-
T
A
L
S
F
L
S
W
-
L
G
S
I
T
S
S
A
I
V
Y
L
C
S
N
A
SPLKA
W
G
L
L
L
S
I
L
F
A
E
H
F
Y
L
V
V
Q
L
A
V
R
F
V
L
S
K
L
D
S
-
P
G
L
Q
K
E
R
K
E
R
F
Q
T
K
K
R
L
L
Q
E
N
L
G
Q
D
A
A
A
A
P
G
I
E
H
S
E
K
I
T
R
E
A
L
E
E
E
A
R
Q
A
S
I
E
M
F
W
---
Q
R
Q
R
G
M
Q
E
T
I
E
I
G
R
R
M
I
E
Q
Q
L
A
A
G
------
26
HHSearch
76.96
11%
-136
- C2 -
1PW4
-
GLPT_ECOLI
A:
[21-432]
----------------------------------------------------------------------------------------
P
T
Y
-
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
------
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
-
Q
G
F
S
R
G
-
D
L
G
F
A
L
S
G
I
S
I
-------
A
Y
G
F
S
K
F
I
M
G
--
S
V
S
D
----
R
S
-
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
-
A
V
---
M
---
F
V
L
-
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
E
R
------
G
G
I
V
---
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
-------
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
----
L
-
K
E
V
-
K
H
F
A
L
D
K
S
S
----------
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
--
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
-
Y
-
W
M
NP-----
A
G
N
P
T
V
D
M
---
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
--------------
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
--------------
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------------------------------------------
19
Fugue
74.97
13%
-106
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
---------------------------------------------------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
------
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
------
D
-
L
N
V
R
E
G
-
A
V
Q
S
V
M
G
A
Y
L
L
-------
T
Y
G
V
S
Q
L
F
Y
G
--
P
I
S
D
----
R
V
-
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
---
L
---
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
---
R
-
T
Q
L
------
R
H
A
N
---
S
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
-
L
F
L
L
V
L
C
A
G
V
T
F
------------------
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
---------
R
L
L
-------
T
S
Y
K
-
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
------------------
G
A
V
----------
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
------------------------------------------------------------------------
R
P
N
K
R
F
S
--------------
T
L
-
M
W
Q
S
V
I
C
C
-
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
-------------
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
------
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------
16
Fugue
73.19
11%
-130
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
----------------------------------------------------------------------------------
M
-
Y
Y
L
K
N
T
N
-
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
------
G
A
Y
F
P
F
---
F
P
I
W
L
H
D
I
N
-----
H
I
S
K
S
-
D
T
G
I
I
F
A
A
I
S
L
-------
F
S
L
L
F
Q
P
L
F
G
--
L
L
S
D
----
K
L
-
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
-
P
L
---
L
Q
YN
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
----
C
F
N
A
G
A
P
A
V
E
A
F
I
---
E
-
K
V
S
------
R
R
S
N
FEF
G
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
--------------------------
I
-
N
-
N
Q
F
V
F
-
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
-------
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
---------------------
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
----
F
-
T
-
S
-
F
F
A
T
G
E
Q
G
T
----------
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
-
L
L
A
G
T
I
M
S
V
R
I
I
G
-
S
-
S
F
-------
A
T
S
A
L
E
V
V
---
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
--------------
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
--------------
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------------------------------------
29
HHSearch
67.83
15%
-114
- C2 -
2GFP
-
EMRD_ECOLI
A:
[20-360]
-------------------------------------------------------------------------------------------------------------------
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
-
R
D
-
L
N
V
R
E
G
-
A
V
Q
S
V
M
G
A
Y
L
L
-------
T
Y
G
V
S
Q
L
F
Y
G
--
P
I
S
D
----
R
V
-
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
---
L
---
I
A
A
-
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
---
E
R
T
Q
L
------
R
H
A
N
---
S
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
-
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
-
M
P
E
-------
T
R
P
V
D
A
P
---
R
T
--------------------------
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
----
M
G
A
-
V
-
L
G
L
S
S
M
T
V
S
----------
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
--
T
L
M
-
W
Q
S
-
V
I
C
C
L
L
A
G
L
L
M
W
I
-
P
-
D
W
F
G
-----
V
M
N
V
W
T
L
L
---
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
--------------
L
V
-
G
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
-------------
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
--------------------------------------------------------------------------------------------
31
HHSearch
66.26
17%
-163
- C2 -
3WDO
-
?
A:
[11-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G---
M
-
A
-
L
-
Q
G
A
S
E
A
L
I
G
----------
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
--
R
K
P
--
L
I
-
V
G
G
L
A
V
F
A
A
G
S
V
I
-
A
-
A
L
-------
S
D
S
I
W
G
I
I
---
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
--------------
F
I
-
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
--------------
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
30
HHSearch
65.54
12%
-128
- C2 -
2CFQ
-
LACY_ECOLI
A:
[21-395]
---------------------------------------------------------------------------------------------------------------------
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
-
H
D
I
N
H
I
S
K
S
-
D
T
G
I
I
F
A
A
I
S
L
-------
F
S
L
L
F
Q
P
L
F
G
--
L
L
S
D
----
K
L
-
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
Y
N
---
I
---
L
V
G
-
S
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
-----
R
R
S
------
N
F
E
F
---
G
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
F
V
F
-
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
-------
A
P
S
S
A
T
V
A
-
N
A
V
G
A
N
H
S
A
--------------------
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
-
A
-
T
-
G
E
Q
G
T
R
V
F
G
----------
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
--
G
K
N
--
A
L
-
L
L
A
G
T
I
M
S
V
R
I
I
G
-
S
-
S
F
-------
A
T
S
A
L
E
V
V
---
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
--------------
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
--------------
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------------------------------------
4
PsiBlast_PDB
53.19
24%
-156
- C2 -
4ZP2
1
?
A:
[45-172]
-------------------------------------------------------------------------------------------------------------------------------------------------
W
V
P
T
S
M
T
A
-------
Y
L
-
A
G
G
M
F
L
Q
--
W
L
L
G
P
L
S
D
R
I
-
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
---
F
---
T
L
L
R
-
F
L
Q
G
I
S
L
C
F
---------
I
G
A
V
G
Y
A
A
---
I
-
R
E
S
F
E
E
A
V
C
I
K
I
T
---
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
--------------------------
V
L
P
-
W
E
G
M
F
-
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
R
A
-
M
P
E
-------
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
-------
L
A
L
G
-
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
----
F
-
G
-
A
-
L
I
A
G
N
L
L
L
A
----------
R
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
-
H
A
Y
L
W
M
T
A
G
L
S
I
Y
-
A
-
F
G
-------
I
G
L
A
N
A
G
L
---
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
S
K
--------------
H
A
-
W
L
N
G
G
N
G
L
-
F
N
L
F
N
L
V
N
G
I
L
W
L
S
L
M
-------------
V
I
F
L
K
-----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.58
24%
-152
- C2 -
4ZP0
1
?
A:
[45-172]
-------------------------------------------------------------------------------------------------------------------------------------------------
W
V
P
T
S
M
T
A
-------
Y
L
-
A
G
G
M
F
L
Q
--
W
L
L
G
P
L
S
D
R
I
-
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
---
F
---
T
L
L
R
-
F
L
Q
G
I
S
L
C
F
---------
I
G
A
V
G
Y
A
A
---
I
-
R
E
S
F
E
E
A
V
C
I
K
I
T
---
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
--------------------------
V
L
P
-
W
E
G
M
F
-
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
R
A
-
M
P
E
-------
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
-------
L
A
L
G
-
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
----
F
-
G
-
A
-
L
I
A
G
N
L
L
L
A
----------
R
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
-
H
A
Y
L
W
M
T
A
G
L
S
I
Y
-
A
-
F
G
-------
I
G
L
A
N
A
G
L
---
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
S
K
--------------
H
A
-
W
L
N
G
G
N
G
L
-
F
N
L
F
N
L
V
N
G
I
L
W
L
S
L
M
-------------
V
I
F
L
K
-----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.47
25%
-145
- C2 -
4APS
-
?
A:
[61-188]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
I
Y
A
S
-------
M
V
Y
L
S
G
T
I
G
G
--
F
V
A
D
----
R
I
I
G
A
R
P
A
V
F
W
G
---
G
V
L
I
M
L
G
H
I
V
L
A
L
P
---
F
----
G
A
-
S
A
---
L
---
F
G
S
I
I
L
I
I
-
I
G
T
G
F
----
L
K
P
N
V
S
T
L
V
G
T
L
Y
D
EH
D
-
R
R
R
------
D
A
G
F
---
S
I
-
F
V
F
G
I
N
L
G
A
F
I
A
P
L
I
V
G
A
A
Q
E
--------------------------
A
A
G
-
Y
H
V
A
F
S
L
A
A
I
G
M
F
I
G
L
L
V
Y
Y
F
G
G
-
K
K
T
-------
L
D
P
H
Y
L
R
P
T
D
P
L
A
P
E
E
V
K
P
L
L
V
K
V
S
L
A
V
A
G
F
-------
I
A
I
I
-
V
V
M
N
L
V
G
W
N
S
L
P
A
Y
I
N
L
L
T
I
V
A
I
A
I
P
V
F
Y
F
A
W
M
I
V
----
V
-
S
-
Y
-
I
P
L
F
I
A
A
V
L
----------
F
W
A
I
E
E
Q
G
S
V
V
L
A
T
F
A
A
E
R
V
D
S
S
W
F
P
V
S
W
F
Q
S
L
N
-
P
L
F
I
M
L
Y
T
P
F
F
A
W
-
L
-
W
T
-------
A
W
K
K
N
S
P
T
---
K
F
A
V
G
L
M
F
A
G
L
S
F
L
L
M
A
I
P
G
A
L
Y
G
T
S
G
K
V
S
P
L
W
L
V
--------------
G
S
-
W
A
L
V
I
L
G
E
-
M
L
I
S
P
V
G
L
S
V
T
T
K
L
A
P
-------------
K
A
F
N
S
Q
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
V
L
G
I
V
L
V
F
L
---------------------------------------------------------
2
PsiBlast_PDB
51.16
24%
-158
- C2 -
4ZOW
1
?
A:
[44-171]
-------------------------------------------------------------------------------------------------------------------------------------------------
W
V
P
T
S
M
T
A
-------
Y
L
-
A
G
G
M
F
L
Q
--
W
L
L
G
P
L
S
D
R
I
-
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
---
F
---
T
L
L
R
-
F
L
Q
G
I
S
L
C
F
---------
I
G
A
V
G
Y
A
A
---
I
-
R
E
S
F
E
E
A
V
C
I
K
I
T
---
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
--------------------------
V
L
P
-
W
E
G
M
F
-
V
L
F
A
A
L
A
A
I
S
F
F
G
L
Q
R
A
-
M
P
E
-------
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
-------
L
A
L
G
-
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
----
F
-
G
-
A
-
L
I
A
G
N
L
L
L
A
----------
R
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
-
H
A
Y
L
W
M
T
A
G
L
S
I
Y
-
A
-
F
G
-------
I
G
L
A
N
A
G
L
---
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
S
K
--------------
H
A
-
W
L
N
G
G
N
G
L
-
F
N
L
F
N
L
V
N
G
I
L
W
L
S
L
M
-------------
V
I
F
L
K
-----------------------------------------------------------------------------------------------------------
35
HHSearch
50.98
14%
-120
- C2 -
2CFQ
-
LACY_ECOLI
A:
[256-396]
-----------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
R
-
V
F
G
Y
V
T
T
M
G
E
L
-------
L
N
A
S
I
M
F
F
A
P
--
L
I
I
N
----
R
I
-
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
I
L
-
K
T
L
H
M
F
E
V
P
F
----
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
F
S
------
A
T
I
Y
---
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
-
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
-
L
S
G
-------
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.48
25%
-142
- C2 -
4D2B
3
?
A:
[61-188]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
I
Y
A
S
-------
M
V
Y
L
S
G
T
I
G
G
--
F
V
A
D
----
R
I
I
G
A
R
P
A
V
F
W
G
---
G
V
L
I
M
L
G
H
I
V
L
A
L
P
---
F
----
G
A
-
S
A
---
L
---
F
G
S
I
I
L
I
I
-
I
G
T
G
F
----
L
K
P
N
V
S
T
L
V
G
T
L
Y
DEH
D
-
R
R
R
------
D
A
G
F
---
S
I
-
F
V
F
G
I
N
L
G
A
F
I
A
P
L
I
V
G
A
A
Q
E
--------------------------
A
A
G
-
Y
H
V
A
F
S
L
A
A
I
G
M
F
I
G
L
L
V
Y
Y
F
G
G
-
K
K
T
-------
L
D
P
H
Y
L
R
P
T
D
P
L
A
P
E
E
V
K
P
L
L
V
K
V
S
L
A
V
A
G
F
-------
I
A
I
I
-
V
V
M
N
L
V
G
W
N
S
L
P
A
Y
I
N
L
L
T
I
V
A
I
A
I
P
V
F
Y
F
A
W
M
I
S
----
L
-
R
-
V
-
V
S
Y
I
P
L
F
I
A
----------
A
V
L
F
W
A
I
E
E
Q
G
S
V
V
L
A
T
F
A
A
E
R
V
D
S
S
W
F
P
V
S
W
F
Q
-
S
L
N
P
L
F
I
M
L
Y
T
P
F
-
F
-
A
W
-------
L
W
T
A
N
Q
P
S
---
S
P
T
K
F
A
V
G
L
M
F
A
G
L
S
F
L
L
M
A
I
P
G
A
L
Y
G
T
S
G
K
V
S
P
L
--------------
W
L
-
V
G
S
W
A
L
V
I
-
L
G
E
M
L
I
S
P
V
G
L
S
V
T
T
M
-------------
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
V
L
G
I
V
L
V
F
L
S
---------------------------------------------------------------
13
PsiBlast_PDB
50.24
25%
-142
- C2 -
4D2D
3
?
A:
[61-188]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
I
Y
A
S
-------
M
V
Y
L
S
G
T
I
G
G
--
F
V
A
D
----
R
I
I
G
A
R
P
A
V
F
W
G
---
G
V
L
I
M
L
G
H
I
V
L
A
L
P
---
F
----
G
A
-
S
A
---
L
---
F
G
S
I
I
L
I
I
-
I
G
T
G
F
----
L
K
P
N
V
S
T
L
V
G
T
L
Y
DEH
D
-
R
R
R
------
D
A
G
F
---
S
I
-
F
V
F
G
I
N
L
G
A
F
I
A
P
L
I
V
G
A
A
Q
E
--------------------------
A
A
G
-
Y
H
V
A
F
S
L
A
A
I
G
M
F
I
G
L
L
V
Y
Y
F
G
G
-
K
K
T
-------
L
D
P
H
Y
L
R
P
T
D
P
L
A
P
E
E
V
K
P
L
L
V
K
V
S
L
A
V
A
G
F
-------
I
A
I
I
-
V
V
M
N
L
V
G
W
N
S
L
P
A
Y
I
N
L
L
T
I
V
A
I
A
I
P
V
F
Y
F
A
W
M
I
S
----
S
-
S
-
T
-
E
H
L
R
V
V
S
Y
I
----------
P
L
F
I
A
A
V
L
F
W
A
I
E
E
Q
G
S
V
V
L
A
T
F
A
A
E
R
V
D
S
S
W
F
P
-
V
S
W
F
Q
S
L
N
P
L
F
I
M
-
L
-
Y
T
-------
P
F
F
A
W
L
W
T
---
A
W
K
K
N
Q
P
S
S
P
T
K
F
A
V
G
L
M
F
A
G
L
S
F
L
L
M
A
I
P
G
A
L
Y
G
--------------
T
S
-
G
K
V
S
P
L
W
L
-
V
G
S
W
A
L
V
I
L
G
E
M
L
I
S
P
-------------
V
G
L
S
V
T
T
K
N
S
Q
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
V
L
G
I
V
L
V
F
L
S
K
R
I
Q
G
L
---------------------------------------------
32
HHSearch
50.08
14%
-122
- C2 -
2GFP
-
EMRD_ECOLI
A:
[22-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
----
A
-
R
-
D
-
L
N
V
R
E
G
A
V
Q
----------
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
--
R
R
P
--
V
I
-
L
V
G
M
S
I
F
M
L
A
T
L
V
-
A
-
V
T
-------
T
S
S
L
T
V
L
I
---
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
--------------
L
L
-
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
--------------
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
15
PsiBlast_PDB
49.75
25%
-142
- C2 -
4XNJ
4
?
A:
[61-188]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
I
Y
A
S
-------
M
V
Y
L
S
G
T
I
G
G
--
F
V
A
D
----
R
I
I
G
A
R
P
A
V
F
W
G
---
G
V
L
I
M
L
G
H
I
V
L
A
L
P
---
F
----
G
A
-
S
A
---
L
---
F
G
S
I
I
L
I
I
-
I
G
T
G
F
----
L
K
P
N
V
S
T
L
V
G
T
L
Y
DEH
D
-
R
R
R
------
D
A
G
F
---
S
I
-
F
V
F
G
I
N
L
G
A
F
I
A
P
L
I
V
G
A
A
Q
E
--------------------------
A
A
G
-
Y
H
V
A
F
S
L
A
A
I
G
M
F
I
G
L
L
V
Y
Y
F
G
G
-
K
K
T
-------
L
D
P
H
Y
L
R
P
T
D
P
L
A
P
E
E
V
K
P
L
L
V
K
V
S
L
A
V
A
G
F
-------
I
A
I
I
-
V
V
M
N
L
V
G
W
N
S
L
P
A
Y
I
N
L
L
T
I
V
A
I
A
I
P
V
F
Y
F
A
W
M
I
S
----
S
-
T
-
S
-
T
E
H
L
R
V
V
S
Y
----------
I
P
L
F
I
A
A
V
L
F
W
A
I
E
E
Q
G
S
V
V
L
A
T
F
A
A
E
R
V
D
S
S
W
F
-
P
V
S
W
F
Q
S
L
N
P
L
F
I
-
M
-
L
Y
-------
T
P
F
F
A
W
L
W
---
T
A
W
K
K
N
Q
P
S
S
P
T
K
F
A
V
G
L
M
F
A
G
L
S
F
L
L
M
A
I
P
G
A
L
Y
--------------
G
T
-
S
G
K
V
S
P
L
W
-
L
V
G
S
W
A
L
V
I
L
G
E
M
L
I
S
-------------
P
V
G
L
S
V
T
T
K
L
N
S
Q
M
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
Q
L
V
T
L
Y
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
V
L
G
I
V
L
V
F
L
S
K
R
I
Q
G
L
-------------------------------------------
12
PsiBlast_PDB
49.08
25%
-137
- C2 -
4D2C
3
?
A:
[61-188]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
I
Y
A
S
-------
M
V
Y
L
S
G
T
I
G
G
--
F
V
A
D
----
R
I
I
G
A
R
P
A
V
F
W
G
---
G
V
L
I
M
L
G
H
I
V
L
A
L
P
---
F
----
G
A
-
S
A
---
L
---
F
G
S
I
I
L
I
I
-
I
G
T
G
F
----
L
K
P
N
V
S
T
L
V
G
T
L
Y
DEH
D
-
R
R
R
------
D
A
G
F
---
S
I
-
F
V
F
G
I
N
L
G
A
F
I
A
P
L
I
V
G
A
A
Q
E
--------------------------
A
A
G
-
Y
H
V
A
F
S
L
A
A
I
G
M
F
I
G
L
L
V
Y
Y
F
G
G
-
K
K
T
-------
L
D
P
H
Y
L
R
P
T
D
P
L
A
P
E
E
V
K
P
L
L
V
K
V
S
L
A
V
A
G
F
-------
I
A
I
I
-
V
V
M
N
L
V
G
W
N
S
L
P
A
Y
I
N
L
L
T
I
V
A
I
A
I
P
V
F
Y
F
A
W
Y
I
P
----
L
-
F
-
I
-
A
A
V
L
F
W
A
I
E
----------
E
Q
G
S
V
V
L
A
T
F
A
A
E
R
V
D
S
S
W
F
P
V
S
W
F
Q
S
L
N
P
L
F
I
M
-
L
Y
T
P
F
F
A
W
L
W
T
A
W
-
S
-
S
P
-------
T
K
F
A
V
G
L
M
---
F
A
G
L
S
F
L
L
M
A
I
P
G
A
L
Y
G
T
S
G
K
V
S
P
L
W
L
V
G
S
W
A
L
V
I
--------------
L
G
-
E
M
L
I
S
P
V
M
-
M
S
M
W
F
L
S
S
S
V
G
S
A
L
N
A
-------------
Q
L
V
T
L
Y
N
A
K
S
E
V
A
Y
F
S
Y
F
G
L
G
S
V
V
L
G
I
V
L
V
F
L
S
-------------------------------------------------------------------------------