@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYCT_HUMAN: (2015-12-08 )
MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSPRITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDVE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....------...110--------------.-.--------......120.......130.......140..----.....150..---....----------.160....------------------.----.---.----170......--------..180.....----..190.......200.......210.......220.....------..230----...------------------------......240.......250....-..--.260...-....270.......280.......290.......300.......310-.......320.......330.......340---------.......350...-....360.......370.-......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530......-.540......-.550.....-..560...------.---...570..---.....580.......590.......600.......610.......620.......630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRKASE
N
V
E
Y
T
L
R
S
L
S
S
L
M
G
E
R
RRKQPEPDAASAAGE
C
S
L
L
A
AAESSTSLQSAGAGGGG
V
G
D
L
E
R
A
A
R
R
Q
F
QQDET
P
A
F
V
Y
V
V
A
V
F
S
A
L
G
G
F
L
F
GYD
T
G
V
V
S
G
A
M
------
L
L
L
K
R
---------------Q-L--------
S
L
D
A
L
W
Q
E
L
L
V
SST
V
G
A
A
A
V
S
A
L
AGG
A
L
N
G
V
----
F
G
R
R
A
A
I
L
L
A
---
S
A
L
F
----------TA
G
S
A
V
L
A
------------------A----A---N----N-K
E
T
L
L
A
G
--------
R
L
V
V
G
L
GI
G
I
----
A
S
M
T
V
P
V
Y
I
A
EVSPPNLR
G
R
L
V
T
I
N
T
L
F
IT
G
G
Q
F
F
A
S
V
V
D
------
G
A
F
------
S
Y
L
------------------------QKDG
W
R
Y
M
L
G
L
A
A
V
P
A
V
I
Q
F
F
G
F
-
L
F--LPES
P
R
W
-
L
I
QKG
Q
T
Q
K
A
R
R
I
L
S
Q
MRGNQ
T
I
D
E
E
Y
D
S
I
K
N
N
I
E
E
E
E
K
EVGSA
G
P
V
-
I
C
R
MLSYPPTR
R
A
L
I
V
G
C
G
L
Q
M
F
Q
Q
LSGI
N
---------
T
I
M
Y
Y
S
A
T
I
L
Q
MS-GVEDD
R
L
A
I
W
L
A
S
V
T
A
F
T
-
N
F
I
F
T
L
V
G
V
W
L
V
E
K
VGRRKLTFGSL
A
G
T
T
V
A
L
I
I
L
A
L
G
F
V
L
SAQVSP
R
I
T
F
K
PIAPSGQNA
T
C
T
R
Y
S
Y
C
N
ECMLDPDC
G
F
C
Y
KMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTE
D
I
F
W
A
Y
NFCPTPY
S
W
T
A
L
L
G
L
I
L
Y
L
V
F
FAPGMGPM
P
W
T
VNS
E
I
Y
P
L
-
W
ARSTGN
A
C
S
-
S
G
I
N
W
I
F
N
V
-
L
V
S
L
T
F
L
H
------
T
---
A
E
Y
L
T
Y
Y
G
---
A
F
F
L
Y
A
G
F
A
A
V
G
L
L
F
I
Y
GCLPETKG
K
K
L
E
E
I
E
S
L
F
DN
R
L
CTCGTSDSDEG
R
Y
I
E
Y
I
R
VKGSNYHLSDNDASDVE
23
Fugue
92.54
30%
-100
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------------------------------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
------
E
S
L
N
T
---------------
V
-
F
VAPQNLS
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
----
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
----------
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
------
Y
F
I
A
R
S
GD
A
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
----------
G
G
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
----------------------------------------------------------------------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
---
V
A
H
F
H
N
G
F
---
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------
24
Fugue
88.35
32%
-129
- C2 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
------------------------------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
------
E
S
L
N
T
V
FVAPQNLS------
E
-
S
--------
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-----
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
----------
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
----
A
---
G
----
Y
-
V
P
E
F
V
I
Y
--------
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
------
Y
F
I
A
R
SGD
A
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
-
M
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--------------------------------
R
L
L
M
F
--
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
-
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
----------------------------------------------------------------------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
NGF
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
----------------------------------------------
7
PsiBlast_PDB
78.26
32%
-97
- C2 -
4ZW9
4
?
A:
[26-363]
-------------------------------------------------------------------------
Q
K
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
F
I
T
K
T
L
T
D
K
GNAPPS
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
L
CK---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.62
32%
-97
- C2 -
4ZWB
1
?
A:
[26-363]
-------------------------------------------------------------------------
Q
K
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
F
I
T
K
T
L
T
D
K
GNAPPS
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
L
CK---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
77.23
32%
-98
- C2 -
4ZWC
2
?
B:
[26-363]
-------------------------------------------------------------------------
Q
K
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
FITKTLTDKGNAPPS
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
LCK---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.01
32%
-100
- C2 -
4ZWC
3
?
A:
[26-363]
-------------------------------------------------------------------------
Q
K
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
F
I
T
K
T
L
T
D
K
GNAPPS
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
L
CK---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.60
29%
-89
- C2 -
4PYP
1
GTR1_HUMAN
A:
[19-361]
---------------------------------------------------------------------------------------
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
------
K
V
I
E
E
F
Y
T
Q
T
W
V
H
R
YG
E
S
I
L
P
-
T
--------
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
M
M
---
N
-
L
L
----------
A
F
V
S
A
V
L
M
------------------
G
F
SKL
G
---
K
----
S
-
F
E
M
L
I
L
G
--------
R
F
I
I
G
V
Y
C
G
L
----
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
------
L
D
S
------
I
M
G
------------------------
N
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
---
E
E
S
R
Q
M
M
R
E
K
K
V
T
-
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
S
I
F
E
K
A
-
G
V
Q
Q
P
---
V
Y
A
T
I
G
S
G
I
V
-
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
C
G
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.46
32%
-97
- C2 -
5C65
8
?
A:
[5-341]
--------------------------------------------------------------------------
K
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
F
I
Q
K
T
L
T
D
KGNAPPS
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
L
C
K---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-----
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_CBE
73.92
32%
-97
- C2 -
5C65
7
?
B:
[6-341]
---------------------------------------------------------------------------
V
T
P
A
L
I
F
A
I
T
V
-
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
F
I
Q
K
T
L
T
D
KAPPS--
E
-
V
--------
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
-
I
G
S
F
S
V
G
L
F
V
N
R
----
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
----------
V
T
G
G
C
F
M
G
L
C
K---------------
V
----
A
---
K
----
S
-
V
E
M
L
I
L
G
--------
R
L
V
I
G
L
F
C
G
L
----
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
------
L
E
F
------
I
L
G
------------------------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
-
P
F
--
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
---
Q
V
T
V
L
E
-
L
F
R
V
S
S
Y
---
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
---------
A
V
F
Y
Y
S
T
G
I
F
K
D
A
----
E
P
I
Y
A
T
I
G
A
G
V
---
V
-
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.82
30%
-94
- C2 -
4GBZ
4
XYLE_ECOLI
A:
[8-367]
------------------------------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
---------------
N
-
L
--------
S
E
S
A
--
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
G
F
T
S
I
N
------------------
P
----
D
---
N
----
T
-
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
------
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--------
R
L
L
M
F
--
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
A
S
T
D
-
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.50
30%
-92
- C2 -
4GC0
4
XYLE_ECOLI
A:
[8-367]
------------------------------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
---------------
N
-
L
--------
S
E
S
A
--
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WP
E
L
G
F
T
S
I
N
------------------
P
----
D
---
N
----
T
-
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
------
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--------
R
L
L
M
F
--
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
A
S
T
D
-
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.40
30%
-93
- C2 -
4GBY
4
XYLE_ECOLI
A:
[8-367]
------------------------------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
---------------
N
-
L
--------
S
E
S
A
--
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WP
E
L
G
F
T
S
I
N
------------------
P
----
D
---
N
----
T
-
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
------
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
--------
R
L
L
M
F
--
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
A
S
T
D
-
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.22
30%
-97
- C2 -
4JA3
-
XYLE_ECOLI
A:
[8-367]
------------------------------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
---------------
N
-
L
--------
S
E
S
A
--
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WP
E
L
G
F
T
S
I
N
------------------
P
----
D
---
N
----
T
-
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
------
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
---------------------
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
-------
S
T
D
-
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.22
36%
-74
- C2 -
4LDS
-
?
A:
[22-323]
-------------------------------------------------------------------------------------------------
D
N
G
V
I
S
G
A
L
------
L
F
I
H
K
---------------
D
-
I
--------
P
L
N
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
----
L
G
R
R
R
L
V
M
L
I
---
A
I
V
F
----------
I
I
G
A
L
I
L
A
------------------
A
----
S
---
T
----
N
-
L
A
L
L
I
I
G
--------
R
L
I
I
G
L
A
V
G
G
----
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
------
Y
A
F
------
A
--------------------------
D
I
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
-
Y
F
--
M
P
E
S
P
R
W
-
L
L
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
--------
K
E
M
K
E
I
N
A
I
S
E
S
-
T
W
T
V
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
---------
A
V
I
F
Y
S
S
S
I
F
A
K
A
-
G
L
G
E
A
--
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
L
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.64
30%
-100
- C2 -
4JA4
-
XYLE_ECOLI
A:
[9-367]
-------------------------------------------------------------------------------
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
---------------
N
-
L
--------
S
E
S
A
--
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
G
F
T
S
I
N
------------------
P
----
D
---
N
----
T
-
V
P
V
Y
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
RS
G
D
A
------
S
W
L
------------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
-
Y
T
--
V
P
E
S
P
R
W
-
L
M
----
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
----------------
M
F
--
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
---------
V
V
L
Y
Y
A
P
E
V
-------------
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
60.88
13%
-102
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
---------------------------------
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
------
P
Y
L
V
----------------
E
-
Q
--------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
----
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
----------
A
A
V
M
L
F
M
G
F
V
P
W
--------------
A
----
T
---
S
----
S
-
I
A
V
M
F
V
L
--------
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
------
L
L
G
------
M
A
W
------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
A
--
M
M
R
D
T
---------------------------------
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
-
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
---------
I
L
D
W
S
P
T
Y
L
K
E
V
K
-
H
F
-
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
-
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
-----
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
-----------------------------------------------------------------------------------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
-
L
F
G
Y
L
G
G
S
V
-
A
A
S
A
I
V
G
Y
------
T
---
V
D
F
F
G
W
D
G
---
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------
33
HHSearch
56.21
12%
-101
- C2 -
1PW4
-
GLPT_ECOLI
A:
[23-448]
----------------------------------------------------------------------------
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
------
P
Y
L
V
----------------
E
-
Q
--------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
----
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
----------
A
A
V
M
L
F
M
G
------------------
F
----
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
L
--------
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
------
L
L
G
------
M
-
A
------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
--
M
R
D
T
P
Q
S
-
C
G
L
P
P
I
E
E
Y
K
N
D
------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
-----
A
N
V
F
V
Y
L
L
R
Y
---------
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
-
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
-
P
--------------------------------------------------------------------------------------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
-
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
-
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
------
T
---
V
D
F
F
G
W
D
G
---
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------
35
HHSearch
52.38
14%
-80
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[29-331]
-------------------------------------------------------------------------------------
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
------
P
Q
F
Q
Q
---------------
A
-
F
--------
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
----
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
----------
A
L
G
A
A
L
F
W
------------------
P
----
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
G
--------
L
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
------
Q
S
L
------
I
L
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
-
M
L
T
K
F
P
A
L
Q
S
D
----
N
H
S
-
D
A
-
K
-----------------------------
Q
G
S
F
S
A
S
-
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
-----
A
Q
F
C
Y
V
G
A
Q
T
---------
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
-
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
51.34
10%
-61
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-----------------------------------------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
------
A
D
M
A
R
---------------
D
-
L
--------
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
----
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
----------
M
L
A
T
L
V
A
V
------------------
T
----
T
---
S
----
S
-
L
T
V
L
I
A
A
--------
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
------
G
L
--------
L
D
------------------------
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
-
A
R
W-
M
P
E
T
R
P
----
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
-
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
RPNK
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
-
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
-
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
50.15
10%
-91
- C2 -
2CFQ
-
LACY_ECOLI
A:
[16-398]
-------------------------------------------------------------------------------------------
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
------
P
I
W
L
H
---------------
D
I
N
--------
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
----
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
----------
F
A
P
F
F
I
F
I
------------------
F
----
G
---
P
----
L
L
Q
Y
N
I
L
V
G
--------
S
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
------
G
I
M
------
F
--------------------------
T
-
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
-
F
F
--
A
K
T
D
A
P
S
-
S
A
T
-
V
A
N
A
V
G
---------------------------
A
N
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
-
S
C
T
Y
D
V
F
D
Q
---------
Q
F
A
N
F
F
T
S
F
F
A
T
G
-
E
Q
-
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
-
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
--------------------------------------------------------------------------------------------
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
-
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
-
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
------
M
---
Y
E
S
I
G
F
Q
G
---
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-------------------------------------