@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NCKX3_HUMAN: (2015-12-08 )
MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.-----......220..-.....---230.......240.......250.....-------------..260.......270.......280.......--290.......300..-.....310----.......320.......330.......340.......350.-......360......----.370..-.....380.......390-------.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRPSG
D
E
D
R
A
R
R
R
R
R
R
R
R
R
R
D
L
L
L
S
Q
L
C
F
L
A
S
V
A
L
L
L
W
S
L
S
S
L
R
E
Q
K
EL
D
L
M
D
L
VGED
R
K
W
M
M
A
R
K
L
M
Q
VNDTLTSEDAGLRNSKNCT
E
P
A
L
H
EF
P
N
D
IFT
N
E
D
RR
Q
G
A
V
V
L
H
V
L
C
A
I
Y
M
F
Y
A
L
A
I
V
CDDF
F
V
P
S
L
E
K
I
C
E
R
LHLSEDVAG
A
T
F
MAAGSS
A
P
E
L
F
T
S
V
I
G
V
F
ITKGDV
G
V
G
T
I
V
G
S
A
V
F
N
I
L
C
I
I
G
V
C
G
L
F
A
G
Q
V
V
A
L
S
S
W
C
L
-----
L
R
D
S
I
Y
Y
T
L
S
V
-
I
A
L
I
V
---
F
IYDE
K
V
S
W
W
E
S
L
V
L
V
L
M
Y
L
I
Y
I
V
I
M
K
Y
-------------
N
A
C
I
H
Q
C
F
E
R
R
TKGAG
N
M
V
N
GLANNAEIDDSS--NC
D
A
T
V
V
L
L
KKANFH-RK
A
S
V
I
M
V
----
D
E
L
L
S
AYPHQLSFSEA
G
L
R
I
M
I
TSHFPP
K
T
R
L
S
M
A
S
R
M
L
I
N
-
E
R
Q
R
L
I
N
SRAYTNGE----
S
E
V
A
I
K
-IP
I
K
H
TVENGTGPSSAPD-------RGVNGTRR
D
D
V
V
A
EAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGK
L
E
T
V
K
W
A
F
TWP
L
S
F
V
L
Y
F
TVPNCNKPR
W
E
K
W
F
M
V
T
FASS
T
L
W
I
A
A
F
S
Y
M
M
V
W
M
V
T
I
I
G
YTLG
I
P
D
V
I
M
G
I
T
F
LAAGTS
V
P
D
C
M
A
S
L
I
V
A
RQGMGD
M
A
VSNSIG
S
N
V
F
D
I
L
I
GLG
L
P
W
A
L
Q
T
L
A
VDYG
S
Y
I
R
LNSR
G
L
I
Y
S
V
G
L
L
L
A
S
V
F
V
T
V
F
G
VHL
N
K
WQLDKKLG
C
G
C
L
L
L
Y
G
V
F
L
C
F
S
I
M
T
EFN
V
F
T
F
V
NLPMCGDH
6
HHSearch
88.74
25%
-115
- C7 -
3V5U
13
Y091_METJA
A:
[14-304]
--------------------------------------------------------------------------------------------------------------------------
I
L
L
Y
Y
G
S
D
W
F
V
L
G
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
G
T
S
L
P
E
I
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
I
G
S
C
I
C
N
I
G
L
V
L
G
L
S
A
I
I
S
P
--
I
I
V
D
K
-
N
L
-----
Q
K
N
I
L
V
Y
L
L
F
V
-
I
F
A
A
V
----
I
G
I
D
G
F
S
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
-------------
N
G
----------
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
N
N
P
-------------------------------------
S
V
V
F
--
S
L
V
L
L
I
I
G
L
I
G
V
L
V
G
A
E
L
F
V
D
G
A
K
K
I
A
L
A
L
D
I
S
D
K
V
I
G
F
T
L
V
A
F
G
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
M
V
L
G
N
V
I
G
S
N
I
A
D
I
G
G
A
L
A
V
G
S
L
F
M
H
L
P
--------
A
E
N
V
Q
--
M
A
V
L
-
V
I
M
S
L
L
L
---
Y
L
F
A
K
Y
S
K
I
G
R
W
Q
G
I
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
G
--------------
15
Fugue
85.86
19%
-78
- C7 -
3V5U
13
Y091_METJA
A:
[1-304]
-------------------------------------------------------------------------------------------------------------
M
V
I
L
G
V
G
Y
F
L
L
G
L
I
L
L
Y
Y
G
S
D
W
F
V
L
G
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
G
T
S
L
P
E
I
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
I
G
S
C
I
C
N
I
G
L
V
L
G
L
S
A
I
I
S
P
I
I
V
D
----
K
N
-----
L
Q
K
N
I
L
V
Y
L
L
F
-
V
I
F
A
A
---
V
I
G
I
D
G
F
S
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
N
G
SAKNN
P
S
V
V
F
S
L
V
L
L
I
I
G
L
I
G
V
L
V
G
A
E
L
F
V
D
G
A
K
K
I
A
L
A
L
D
I
S
D
K
V
I
G
F
T
L
V
A
F
G
T
S
L
P
E
-
L
M
V
S
L
A
A
A
K
R
NL
G
G
M
V
L
G
N
V
I
G
S
N
I
A
D
I
G
G
A
L
A
V
G
S
L
F
M
H
L
P
A
E
N
V
Q
M
A
V
L
V
I
-
M
S
L
L
L
Y
L
F
A
K
Y
S
K
I
G
----
R
W
Q
G
I
L
-
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.45
30%
-87
- C7 -
3V5U
9
Y091_METJA
A:
[20-139]
--------------------------------------------------------------------------------------------------------------------------------
S
D
W
F
V
L
G
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
G
T
S
L
P
E
I
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
I
G
S
C
I
C
N
I
G
L
V
L
G
L
S
A
I
I
S
P
I
I
V
---
D
K
N
L
-----
Q
K
N
I
L
V
Y
L
L
F
V
-
I
F
A
A
V
---
I
G
I
D
-
G
F
S
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
-------------
N
G
S
A
K
N
N
P
S
V
V
F
S
L
V
L
L
I
I
G
L
I
G
V
L
V
G
A
E
L
F
V
--
D
G
A
K
K
I
A
L
A
L
D
I
S
D
K
-
V
I
G
F
T
L
V
A
----
F
G
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
M
V
L
G
N
V
I
G
S
N
I
A
D
I
G
G
A
L
A
V
-
G
S
L
F
M
H
L
P
A
E
N
V
Q
M
A
----
V
L
V
I
M
S
-
L
L
L
Y
L
F
A
K
Y
S
K
I
G
R
W
Q
G
I
-------
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
52.02
30%
-83
- C7 -
3V5S
-
Y091_METJA
A:
[20-139]
--------------------------------------------------------------------------------------------------------------------------------
S
D
W
F
V
L
G
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
G
T
S
L
P
E
I
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
I
G
S
C
I
C
N
I
G
L
V
L
G
L
S
A
I
I
S
P
I
I
V
---
D
K
N
L
-----
Q
K
N
I
L
V
Y
L
L
F
V
-
I
F
A
A
V
---
I
G
I
D
-
G
F
S
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
-------------
N
G
P
S
V
V
F
S
L
V
L
L
I
I
G
L
I
G
V
L
V
G
A
E
L
F
V
D
G
A
K
K
--
I
A
L
A
L
D
I
S
D
K
V
I
G
F
T
-
L
V
A
F
G
T
S
L
----
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
M
V
L
G
N
V
I
G
S
N
I
A
D
I
G
G
A
L
A
V
G
S
L
F
M
-
H
L
P
A
E
N
V
Q
M
A
V
L
V
I
M
----
S
L
L
L
Y
L
-
F
A
K
Y
S
K
I
G
R
W
Q
G
I
L
F
L
A
L
-------
Y
I
I
A
I
A
S
L
R
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
51.56
24%
-60
- C7 -
3V5U
10
Y091_METJA
A:
[168-301]
---------------------------------------------------------------------------------------------------------------------
L
I
I
G
L
I
G
V
L
V
G
A
E
L
F
V
D
G
A
K
K
I
A
L
A
L
D
I
S
D
K
V
I
G
F
T
L
V
A
F
G
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
M
V
L
G
N
V
I
G
S
N
I
A
D
I
G
G
A
L
A
V
G
S
L
F
M
H
--
L
P
A
E
N
---------
V
Q
M
A
V
L
V
I
M
S
-
L
L
L
Y
L
---
F
A
K
Y
S
K
I
G
R
W
Q
G
I
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
-------------
G
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.52
25%
-61
- C7 -
4K1C
3
VCX1_YEAST
A:
[272-395]
-------------------------------------------------------------------------------------------------------------------------------
C
A
D
F
L
V
G
T
I
D
N
V
V
E
S
T
G
L
S
K
T
F
I
G
L
I
V
I
P
I
V
G
N
A
A
E
H
V
T
S
V
L
V
A
M
K
D
K
M
D
L
A
L
G
V
A
I
G
S
S
L
--------
Q
V
A
L
F
V
T
P
F
M
V
L
V
G
W
M
I
DVPMT
L
N
F
S
T
F
E
T
A
T
L
F
I
A
V
F
L
S
N
Y
L
I
L
D
G
E
S
N
W
L
E
G
V
M
S
L
A
M
Y
I
L
I
A
M
A
F
F
Y
-------------
Y
P
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
48.03
10%
96
- C7 -
5C3L
-
?
B:
[18-141]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
C
Q
D
----
V
E
N
F
Q
K
F
V
K
E
Q
K
Q
V
Q
E
E
I
S
R
M
S
S
K
A
M
L
K
V
Q
E
D
I
K
A
L
K
Q
L
L
S
-
V
A
S
S
G
L
Q
R
N
A
L
A
I
D
K
----
L
K
I
E
T
A
-
E
E
L
K
N
A
E
I
A
L
R
T
Q
K
T
P
P
G
-------
L
Q
H
E
N
T
A
P
A
D
Y
F
H
T
L
V
Q
Q
F
E
V
Q
L
Q
Q
Y
R
Q
Q
I
E
E
L
E
N
H
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
46.04
21%
184
* C7 *
1CI6
1
B:
[17-63]
---
S
R
D
K
A
K
M
R
N
L
E
T
Q
H
K
V
L
E
L
T
A
E
N
E
R
L
Q
K
K
V
E
Q
L
S
R
E
L
S
T
L
R
N
L
F
K
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
45.87
11%
114
- C7 -
4CJD
-
?
A:
[6-189]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
S
T
D
E
I
A
K
A
A
L
V
G
-
V
Y
N
N
T
Q
D
I
N
G
F
K
V
G
D
----
T
I
Y
D
I
E
--
N
G
Q
P
K
G
R
P
A
T
E
D
D
V
K
A
D
DFGGLG
L
K
E
V
L
A
Q
H
D
Q
S
L
A
D
L
T
G
T
V
E
E
N
S
E
A
L
V
K
T
A
E
V
V
N
D
I
S
A
D
V
K
A
N
T
A
A
I
R
E
N
K
A
A
T
A
N
G
L
E
T
R
L
A
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
43.91
12%
347
- C7 -
1HF9
-
B:
[1-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
-------
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
43.84
12%
347
- C7 -
1HF9
-
ATIF1_BOVIN
A:
[1-41]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
-------
K
K
H
H
E
N
E
I
S
H
H
A
K
E
I
E
R
L
Q
K
E
I
E
R
H
K
Q
S
I
K
K
L
K
Q
S
E
D
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.84
26%
120
- C7 -
1HYG
1
MDH_METJA
A:
[207-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
D
E
I
I
E
D
V
K
T
K
---
G
E
Q
I
I
R
L
K
G
G
S
E
F
G
P
A
A
A
I
L
N
V
V
R
C
I
V
N
-
N
E
K
R
L
L
T
L
S
A
Y
V
D
G
E
FDGI
R
D
V
C
I
G
-
V
P
V
K
I
G
R
D
G
I
E
E
V
V
S
I
E
L
-------
D
K
D
E
I
I
A
F
R
K
S
A
E
I
I
K
K
Y
C
E
E
V
K
N
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.28
26%
118
- C7 -
1HYE
1
MDH_METJA
A:
[207-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
D
E
I
I
E
D
V
K
T
K
---
G
E
Q
I
I
R
------
F
G
P
A
A
A
I
L
N
V
V
R
C
I
V
N
-
N
E
K
R
L
L
T
L
S
A
Y
V
D
G
E
FDGI
R
D
V
C
I
G
-
V
P
V
K
I
G
R
D
G
I
E
E
V
V
S
I
E
L
-------
D
K
D
E
I
I
A
F
R
K
S
A
E
I
I
K
K
Y
C
E
E
V
K
N
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
39.95
8%
165
- C7 -
1NLW
2
MAD1_HUMAN
A:
[1-79]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
S
T
H
N
E
M
E
K
N
R
R
A
----
H
L
R
L
S
L
-
E
K
L
K
G
L
V
P
L
G
P
D
S
S
R
H
T
T
-------
L
S
L
L
T
K
A
K
L
H
I
K
K
L
E
D
S
D
R
K
A
V
H
Q
I
D
Q
L
Q
R
E
Q
R
H
L
K
R
Q
L
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
38.94
10%
57
- C7 -
3RJ1
1
MED8_YEAST
C:
[29-210]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
Q
A
L
D
A
V
R
M
-
R
L
A
Q
L
T
H
S
L
R
R
I
R
D
E
M
S
K
A
E
L
P
Q
W
----
Y
T
L
Q
S
Q
L
N
V
T
L
S
Q
L
V
S
V
T
S
T
L
Q
H
F
Q
E
T
L
D
S
T
V
V
Y
P
L
P
K
F
P
T
T
S
H
E
S
L
V
T
T
L
L
R
K
K
N
I
----
P
E
V
D
E
W
M
K
Y
V
R
E
T
S
G
V
T
T
A
L
L
K
D
E
E
-------
I
E
K
L
L
Q
Q
D
R
E
I
T
N
W
A
R
T
T
F
R
N
E
Y
G
K
H
D
P
F
N
V
D
D
V
L
K
F
T
F
T
G
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
38.83
22%
443
- C7 -
1FMH
3
GCN4_YEAST
A:
[1-31]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
Q
L
E
K
E
V
A
Q
A
E
A
E
N
Y
Q
L
E
Q
E
V
A
Q
L
E
H
E
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
36.31
73%
1221
- C2 -
1G70
-
?
B:
[8-18]
-
R
P
S
G
A
E
R
R
R
R
R
A
A
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
32.60
70%
1547
- C1 -
2X7L
-
REV_HV1B1
M:
[35-44]
-------
R
Q
A
R
R
N
R
R
R
R
W
R
E
R
Q
R
Q
I
H
S
I
S
E
R
I
L
S
T
Y
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
31.55
70%
1399
- C5 -
1ETF
-
REV_HV1W2
B:
[3-12]
-------
R
Q
A
R
R
N
R
R
R
R
W
R
E
R
Q
R
A
A
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
22.21
29%
2579
- C4 -
1TVS
-
?
A:
[55-61]
------------
R
K
K
N
K
Q
R
L
K
A
I
Q
Q
G
R
Q
P
Q
Y
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------