@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NRAM1_HUMAN: (2015-12-08 )
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
Atome Classification :
(20 SA)
--.........10........20--------.........----------30........40........50........60........70---........80--........-----.90..--------......100.----...-....---.110.......120.......130.....-..140.......150.......160....--.-..170.......180.......190.......200----........210.......220.......230.......240.-......250.......260.------.......270.......280.......290.......300.----....----..310........320....------...330..---------------------.....340.......350.------------......360.......370.......380...----------------....390.......400.......410-----..-....------------.--420.....-------------..430.......440.......450-...-----------------.....460.......470.......480.......----------------490--.......500......----------.510-...----....520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MTGDKGPQRLSGSSYGSISS---------PTSPTSPGP----------QQAPPRETYLSEKIPIPDTKPGT
F
S
L
R
K
L
W
AFTGP
G
F
L
M
S
I
A
---
F
LDPGN
I
E
S
---
D
L
Q
A
G
A
V
A
-----
G
F
K
L
L
--------
W
V
L
L
W
A
T
--
V
----
L
G
L
-
L
C
Q
R
---
L
A
A
RLGVVT
G
K
D
L
G
E
V
C
H
L
YYPKVP
R
T
V
L
-
W
L
T
I
E
L
A
I
VG
S
D
M
Q
E
V
I
G
T
A
I
A
F
N
L
LSAG--R-IPLWG
G
V
L
I
T
I
V
D
T
F
F
F
L
F
LDNYG
L
R
K
L
E
A
F
F
G
L
-----
L
I
T
I
M
A
L
T
FGY
E
Y
V
VARPEQG
A
L
L
R
G
L
FLPSCPGCG
H
P
E
L
L
Q
-
A
V
G
I
V
G
A
I
IMP
H
N
I
Y
L
H
-
S
A
------
L
V
K
S
R
E
I
D
R
A
R
RADIREA
N
M
Y
F
L
I
E
A
T
I
A
L
S
V
S
F
I
I
N
L
F
V
M
----
A
V
F
G
----
Q
A
F
Y
-
Q
KTNQ
A
A
F
N
I
CANSS------L
H
D
Y
A
K
I
F
---------------------PMNN
A
T
V
A
V
D
I
YQG
G
V
I
L
G
------------
C
L
F
G
P
A
A
L
Y
I
W
A
I
G
L
LAAGQSSTM
T
G
T
Y
A
G
Q
F
----------------
V
M
E
G
F
L
R
L
R
W
S
R
F
A
R
V
L
L
TRS
C
A
I
L
P
T
-----
V
L
-
V
A
V
F
------------
R
--
D
L
R
D
LS
G
L
-------------
N
D
L
L
N
V
L
Q
S
L
L
L
P
F
A
V
L
P
I
L
TFTS--
M
P
T
-----------------
L
M
Q
E
F
A
N
G
L
L
N
K
V
V
T
S
S
I
M
V
L
V
C
A
I
N
L
Y
F
V
V
S
Y
LP----------------SLP--
H
P
A
Y
F
G
L
A
A
L
L
A
A
A
Y
L
----------
G
L
S
T
-
Y
L
V
----
W
T
C
C
L
AH
G
A
T
F
LAHSSH
H
H
F
L
Y
G
L
L
EEDQKGETSG
2
PsiBlast_PDB
91.48
35%
-130
- C5 -
4WGW
-
?
A:
[5-399]
------------------------------------------------------------------------------------------
V
G
---
Y
M
D
P
G
N
W
I
T
---
S
M
Q
G
G
A
Q
Y
-----
G
Y
T
L
L
--------
F
V
I
L
I
S
S
--
L
----
A
A
M
-
L
L
Q
S
---
M
T
V
R
L
G
I
A
T
G
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
L
A
I
I
A
T
D
I
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
-----
I
P
L
I
V
G
A
L
I
T
V
F
D
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
G
T
-----
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
S
P
Q
L
T
D
I
L
N
G
-
F
V
P
H
K
E
I
V
T
N
Q
G
I
L
Y
I
A
L
G
I
I
G
A
T
I
M
P
H
N
L
Y
L
H
-
S
S
------
I
V
Q
S
R
K
Y
D
R
H
D
N
E
E
K
A
Q
A
I
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
----
T
L
G
A
----
A
L
F
F
G
T
K
T
N
----
D
L
G
G
F
Y
D
------
L
Y
H
A
L
K
T
E
---------------------
P
V
L
G
A
T
L
------
G
G
V
-
M
S
------------
T
L
F
--------
A
V
A
L
L
A
S
G
Q
N
S
T
I
T
G
T
L
A
G
Q
I
----------------
V
M
E
G
F
L
R
L
S
I
P
N
W
L
R
R
L
I
T
R
S
L
A
V
I
P
V
-----
I
I
C
L
I
I
F
------------
K
G-
N
S
E
K
I
E
Q
L
-------------
L
V
F
S
Q
V
F
L
S
I
A
L
P
F
S
L
I
P
L
Q
L
A
T
S
--
N
K
K
-----------------
L
M
G
P
F
I
N
K
T
W
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.29
35%
-130
- C5 -
4WGV
-
?
A:
[5-399]
------------------------------------------------------------------------------------------
V
G
---
Y
M
D
P
G
N
W
I
T
---
S
M
Q
G
G
A
Q
Y
-----
G
Y
T
L
L
--------
F
V
I
L
I
S
S
--
L
----
A
A
M
-
L
L
Q
S
---
M
T
V
R
L
G
I
A
T
G
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
L
A
I
I
A
T
D
I
A
E
V
I
G
S
A
I
A
L
D
L
I
F
G
-----
I
P
L
I
V
G
A
L
I
T
V
F
D
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
G
T
-----
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
S
P
Q
L
T
D
I
L
N
G
-
F
V
P
H
K
E
I
V
T
N
Q
G
I
L
Y
I
A
L
G
I
I
G
A
T
I
M
P
H
N
L
Y
L
H
-
S
S
------
I
V
Q
S
R
K
Y
D
R
H
D
N
E
E
K
A
Q
A
I
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
----
T
L
G
A
----
A
L
F
F
G
T
K
T
N
----
D
L
G
G
F
Y
D
------
L
Y
H
A
L
K
T
E
---------------------
P
V
L
G
A
T
L
------
G
G
V
-
M
S
------------
T
L
F
--------
A
V
A
L
L
A
S
G
Q
N
S
T
I
T
G
T
L
A
G
Q
I
----------------
V
M
E
G
F
L
R
L
S
I
P
N
W
L
R
R
L
I
T
R
S
L
A
V
I
P
V
-----
I
I
C
L
I
I
F
------------
K
G-
N
S
E
K
I
E
Q
L
-------------
L
V
F
S
Q
V
F
L
S
I
A
L
P
F
S
L
I
P
L
Q
L
A
T
S
--
N
K
K
-----------------
L
M
G
P
F
I
N
K
T
W
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
-----------------------------------------------------------------------------------------------------
20
Fugue
90.97
35%
-125
- C5 -
4WGV
-
?
A:
[5-399]
------------------------------------------------------------------------------------------
V
G
---
Y
M
D
P
G
N
W
I
T
---
S
M
Q
G
G
A
Q
Y
-----
G
Y
T
L
L
--------
F
V
I
L
I
S
S
--
L
----
A
A
M
-
L
L
Q
S
---
M
T
V
R
L
G
I
A
T
G
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
I
I
F
-
W
I
I
A
E
L
A
I
I
A
T
D
I
A
E
V
I
G
S
A
I
A
L
D
L
I
F
----
G
-
I
P
L
I
V
G
A
L
I
T
V
F
D
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
G
T
-----
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
S
P
Q
L
T
D
I
L
N
G
F
V
P
H
K
E
I
V
T
N
Q
G
I
L
Y
I
-
A
L
G
I
I
G
A
T
I
M
P
H
N
L
Y
L
H
-
S
S
------
I
V
Q
S
R
K
Y
D
R
H
D
N
E
E
K
A
Q
A
I
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
----
T
L
G
A
----
A
L
F
F
G
T
K
T
N
D
-------
L
G
G
------
F
Y
D
L
Y
H
A
L
---------------------
K
T
E
P
------------
V
L
G
------------
A
T
L
G
G
V
M
S
T
L
F
A
V
A
L
L
A
S
G
Q
N
S
T
I
T
G
T
L
A
G
Q
I
----------------
V
M
E
G
F
L
R
L
S
I
P
N
W
L
R
R
L
I
T
R
S
L
A
V
I
P
V
-----
I
I
-
C
L
I
I
------------
F
KG
N
S
E
K
I
E
Q
L
-------------
L
V
F
S
Q
V
F
L
S
I
A
L
P
F
S
L
I
P
L
Q
L
A
T
S
--
N
K
K
-----------------
L
M
G
P
F
I
N
K
T
W
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
-----------------------------------------------------------------------------------------------------
27
Fugue
76.49
17%
-107
* C4 *
4UIR
2
OLHYD_ELIME
A:
[2-646]
NP
I
T
S
K
F
D
K
V
L
N
A
S
S
E
Y
G
H
V
N
H
EPDSSKEQ
Q
R
N
T
P
Q
K
S
M
P
FSDQIGNYQR
N
K
G
I
P
V
Q
S
Y
D
N
S
K
I
Y
I
I
G
S
G
I
A
G
M
S
A
A
Y
Y
F
I
R
D
G
H
V
P
A
K
N
I
T
---
F
L
E
Q
L
H
I
D
G
GSL
D
G
A
G
N
P
T
D
-----
G
Y
I
I
R
G
G
R
E
M
D
MT
Y
E
N
L
W
D
M
--
F
----
Q
D
I
-
P
A
L
E
---
M
P
A
P
Y
S
V
L
D
E
Y
R
L
I
N
D
N
D
S
N
Y
S
K
A
R
--
L
I
-
N
N
K
G
E
I
K
D
F
S
K
F
G
L
N
K
M
D
Q
L
A
I
I
R
L
L
L
K
N
--
K
-
E
E
L
D
D
---
L
T
I
E
D
Y
F
S
E
S
F
L
K
S
N
F
W
T
F
W
R
T
M
F
A
F
ENWHS
L
L
E
L
K
L
Y
M
H
R
F
L
H
A
I
D
G
L
N
D
---
L
S
S
L
V
F
P
K
-----
Y
N
Q
Y
D
T
-
F
V
T
P
L
R
K
F
L
Q
E
K
G
V
N
I
H
L
N
T
------
L
V
K
D
L
D
I
H
I
N
T
E
G
K
V
V
E
G
I
I
T
E
Q
D
G
K
E
V
K
I
P
V
G
K
--
N
D
Y
V
I
----
V
T
T
G
SMTE
D
T
F
Y
-
G
N
N
K
T
A
P
I
I
G
I
D
N
S
T
SGQSA
G
W
K
L
W
K
N
L
A
---------------------
A
K
S
E
I
F
G
K
P
E
K
F
C
S
N
I
E
K
S
------------
A
-
W
E
S
A
T
L
T
C
K
P
S
A
L
I
D
K
L
K
E
Y
S
V
N
D
P
Y
S
G
K
T
----------------
V
T
G
G
I
I
T
I
T
D
S
N
W
L
M
S
F
T
C
N
R
Q
P
H
F
P
E
QPDD
V
L
V
-
L
W
V
Y
A
LFMDKEGNYIK
K
--
T
M
L
E
C
T
G
D
E
I
L
A
E
L
C
Y
H
L
GIE
D
Q
L
E
N
V
Q
K
N
T
I
V
R
T
A
F
M
P
Y
I
T
S
M
F
--
M
P
R
AKGD
R
P
R
VVPEGCKN
L
G
L
V
G
Q
F
V
E
T
N
N
D
V
V
F
T
M
E
S
S
V
R
T
A
R
I
A
V
Y
K
L
L
N
L
N
K
----------------
Q
V
P
D
I
N
P
L
Q
Y
D
I
R
H
L
L
K
A
A
K
T
L
N
DDKPFVG
E
G
L
L
R
-
K
V
L
KGTY
F
E
H
V
L
P
A
G
E
E
H
E
S
F
I
A
E
H
V
N
K
F
R
E
W
V
K
G
I
R
G
----
21
Fugue
54.21
13%
-119
* C3 *
3J16
3
RLI1_YEAST
B:
[1-608]
--
M
S
D
K
N
--
S
R
I
A
I
V
S
A
D
K
C
K
P
---------
K
K
C
--
R
Q
E
C
----------
K
R
S
C
P
V
V
K
T
G
K
L
C
I
E
V
T
P
T
S
K
I
A
F
I
S
E
I
L
--
C
I
G
C
G
I
C
V
K
K
C
PFD
A
I
Q
I
I
N
L
P
T
---
N
L
E
A
H
V
T
H
RYSAN
S
F
K
L
H
--------
R
L
P
T
P
R
P
G
Q
V
----
L
G
L
-
V
G
T
N
GIG
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
E
------
W
Q
E
I
I
K
Y
F
R
G
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
--
K
-
P
Q
----------------
Y
V
D
N
I
P
R
A
I
K
G
P
V
Q
K
V
-----
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
-
Q
-
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
-
D
E
PSSYLD
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
G
----
V
V
T
L
-
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
------
I
P
A
E
N
L
R
F
RT
E
A
L
Q
F
RIADATEDLQNDSA
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
P
KFPGT
V
R
Q
L
F
F
K
K
I
R
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
-----
I
D
-
D
I
I
D
------------
Q
--
E
V
Q
H
L
S
G
G
-------------
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
AY
L
D
S
-----------------
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
PS
K
N
A
H
A
R
A
P
--
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
----------
T
F
R
R
D
P
N
S
----
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
-----
24
Fugue
40.09
8%
236
- C2 -
2C1M
-
NUP50_MOUSE
B:
[1-46]
--
M
A
K
R
V
A
E
K
E
L
T
D
R
N
W
D
E
------------
E
D
E
V
E
E
M
G
T
----------
F
S
V
A
S
E
E
V
M
K
N
R
A
V
K
K
A
K
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
39.70
15%
208
- C3 -
1CWX
-
POLG_HCVH
A:
[1-44]
-----
S
T
N
P
K
P
Q
R
K
T
K
R
N
T
N
R
R
---------
P
Q
D
V
K
F
P
G
G
----------
G
Q
I
V
G
G
V
Y
L
L
P
R
R
G
P
R
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.13
31%
-26
- C5 -
4WFF
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.66
31%
-21
- C5 -
4WFG
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.64
31%
-24
- C5 -
4I9W
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
38.50
31%
-27
- C5 -
4WFH
1
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
38.29
31%
-27
- C5 -
4WFE
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
37.79
31%
-28
- C5 -
3UM7
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
R
V
V
S
R
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.01
31%
-18
- C5 -
4RUE
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
35.59
31%
-5
- C5 -
4RUF
-
KCNK4_HUMAN
A:
[194-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
S
A
M
--
L
-
F
L
L
I
G
C
L
L
F
V
L
T
P
T
F
V
F
C
Y
M
E
D
W
S
--
K
L
E
A
I
Y
F
V
-----
I
V
T
L
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
S
F
W
I
L
L
G
L
A
Y
F
A
S
-
V
L
T
T
I
G
N
W
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
34.81
12%
-90
- C5 -
2XQ2
2
SGLT_VIBPH
A:
[58-197]
--------------------------------------------------------------------------------------
A
S
L
I
A
A
---
N
I
S
A
E
Q
F
I
G
---
M
S
G
S
G
Y
S
I
-----
G
L
A
I
A
--------
S
Y
E
W
M
S
A
--
I
T
L
I
I
V
G
K
-
Y
F
L
P
---
I
F
I
E
K
---
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
----
G
-
I
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
--
V
V
W
T
D
V
I
Q
V
F
-----
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
-
D
Q
S
N
P
Q
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
------
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
----
V
P
F
L
----
V
V
L
P
-
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
------
S
L
G
N
L
P
S
A
---------------------
A
N
A
D
K
A
Y
P
W
L
T
Q
F
L
P
V
G
V
K
------------
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
----------------
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
-----
A
L
-
I
A
P
M
------------
L
--
G
G
I
G
Q
C
F
Q
-------------
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
--
K
T
T
-----------------
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
----------------
L
F
T
--
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
----------
D
P
K
G
-
I
S
V
----
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
29
Fugue
34.03
14%
133
- C4 -
2JRA
-
?
A:
[1-67]
--
M
M
T
A
S
D
R
L
G
A
D
P
T
Q
A
A
S
S
P
G
---------
G
A
R
A
V
S
I
V
G
----------
N
Q
I
D
S
R
E
L
F
T
V
D
R
E
I
V
I
A
H
G
D
D
R
Y
R
L
R
L
----
T
S
Q
N
K
L
I
L
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
31.28
11%
-82
- C5 -
3DH4
1
?
A:
[59-168]
----------------------------------------------------------------------------------
W
A
V
G
A
S
L
I
A
A
---
N
I
S
A
E
Q
F
I
G
---
M
S
G
S
G
Y
S
I
-----
G
L
A
I
A
--------
S
Y
E
W
M
S
A
--
I
----
T
L
I
I
V
G
K
Y
---
F
L
P
I
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
K
L
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
----
G
-
I
P
L
M
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
-----
V
V
W
T
D
V
I
Q
V
F
-----
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
-
D
Q
S
N
P
Q
Y
M
N
L
P
G
I
A
V
L
I
-
G
G
------
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
----
V
P
F
L
----
V
V
L
P
-
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
------
S
L
G
D
I
A
A
T
---------------------
N
L
P
S
A
A
N
A
D
K
A
Y
P
W
L
T
Q
F
L
------------
P
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
----------------
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
-----
A
L
-
I
I
A
C
------------
L
--
I
A
P
M
L
G
G
I
-------------
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
--
G
L
F
-----------------
W
K
K
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
----------------
M
L
Y
--
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
----------
S
I
N
D
-
D
D
P
----
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
25
Fugue
31.23
20%
155
* C5 *
1IFP
-
?
?:
[1-44]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
-
S
V
------
I
T
D
V
T
G
Q
L
T
A
V
Q
A
D
I
T
T
I
G
G
A
I
I
V
L
A
A
V
V
L
G
I
R
W
I
K
A
Q
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
30.86
7%
-90
- C5 -
2JLN
-
?
A:
[62-178]
----------------------------------------------------------------------------------------------------------------------------
I
--------
V
A
I
A
A
G
C
--
T
----
I
A
V
-
I
L
L
F
---
F
T
Q
S
A
A
I
R
W
G
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
S
L
I
P
-
I
T
L
K
A
L
L
S
L
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
T
G
F
T
N
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
---
F
Y
G
I
T
F
I
R
W
M
N
V
F
-----
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
M
S
M
G
G
E
N
P
G
M
P
F
S
T
A
-
I
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
-
I
V
------
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
----
A
S
M
V
----
L
V
G
E
-
W
N
P
V
I
A
I
T
E
V
V
G
G
V
S
------
I
P
M
A
I
L
F
Q
---------------------
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
------------
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
----------------
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
-----
F
L
-
V
R
R
R
------------
R
--
I
S
L
H
D
L
Y
R
-------------
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
--
V
S
F
-----------------
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
----------------
E
S
R
--
N
E
D
Y
L
R
P
I
G
P
---------------------------------------------------------------