@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : P3_HUMAN: (2015-12-08 )
MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP
Atome Classification :
(19 SA)
---------------------------------------.........10........20........30......-..40........50........60-------.........70-.......--..80..-----.....------.90........100.......110.......120.......130.......140....-...150.......--160...--....170...--....180.......190------.......200---........210.-------......220....---...230.....-----..240....-----.---..250-..----.......260.......270...---....280--.-.-------------------------------.......290.....----..300----------------------------........310..-.....320......-.-330....------------...340-........350--........--------------360.......370.......380.--...-..---.390..-------.....400.......410...---..-------------------..420.......430.......440.....-..450--.........460......-------------.470.....--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------
M
V
L
MQDKGSSQQWPGLGGEGGGT
G
P
L
S
M
L
R
A
A
L
L
L
I
S-LPWGAQGTASTSLSTAGGHTVPP--------TG
G
R
Y
L
SIGD--G
S
V
M
E
F
E--FPEDSE-----
G
I
I
V
I
------SSQYPGQANRTAPG
P
M
L
R
V
T
SLD
T
E
V
L
T
I
K
N
V
S
A
I
T
WGGG
G
G
F
V
V
S
IHSGLAGL
A
P
L
H
-
I
Q
L
V
DAHEAP
P
T
L
--
I
E
E
RR
D
--
F
C
I
K
VSPAED--TP
A
T
L
S
A
D
L
A
HFSENP
I
------
L
Y
L
L
L
P
L
I
-
F
---VNKCSFG
C
K
V
E
L
-------
E
V
L
K
G
L
MQSP
Q
P
M
---
L
L
G
L
L
G
Q
F
L
V
M
-----
P
L
Y
A
F
L
M
A
K
-----
V
---
F
M
L
---
P
K
----
A
L
A
L
G
L
I
I
T
CSSPGG
G
G
S
Y
L
F
S
L
---
L
LGG
D
----
V
-
T
-------------------------------
L
A
I
S
M
T
F
L
S
T
V
A
ATG----FL
P
L
-----------------------------
S
S
A
I
Y
S
R
L
L
S
I
H
E
-
T
L
H
V
P
I
S
K
I
L
G
T
L
L
-
F
-
I
A
I
P
I
A
V
------------
G
V
L
I
K
--
S
KL
P
K
F
S
Q
L
L
---
L
Q
V
V
K
P
F
S
--------------
F
V
L
L
L
G
G
L
F
L
A
Y
R
M
G
V
F
I
LAGIR
L
--
P
I
V
-
L
V
---
G
I
T
V
P
L
-------
V
G
L
L
V
G
Y
C
L
A
T
C
L
KLPVAQ
R
R
---
T
V
-------------------
S
I
E
VGVQ
N
S
L
L
A
L
A
M
L
Q
L
S
L
R
R
L
Q
A
D
YASQ-A
P
F
----
I
V
A
LSG
T
S
E
M
L
A
L
V
I
G
H
F
-------------
I
Y
S
SLFPVP--------------------------
15
Fugue
88.88
22%
-123
- C3 -
3ZUY
8
?
A:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
L
S
K
I
--
S
S
F
I
G
K
--
T
F
S
L
W
A
A
L
F
A
--
A
A
A
F
F
A
P
D
T
F
K
W
A
G
P
Y
I
------
P
W
L
L
G
I
I
M
-
F
-------
G
M
G
L
T
L
K
P
-------
S
D
F
D
I
L
F
K
H
P
K
V
V
---
I
I
G
V
I
A
Q
F
A
I
M
-----
P
A
T
A
W
L
L
S
K
-----
L
---
L
N
L
---
P
A
----
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
---
L
A
R
G
N
----
V
-
A
-------------------------------
L
S
V
A
V
T
S
V
S
T
L
I
S
P
L
----
L
T
P
A
-----------------------------
I
F
L
M
L
A
-----
G
E
-
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
-
K
M
V
L
L
P
I
V
L
------------
G
L
I
V
H
--
K
V
L
G
S
K
T
E
K
L
---
T
D
A
L
P
L
V
S
--------------
V
A
A
I
V
L
I
I
G
A
V
V
G
A
S
K
G
K
I
M
E
S
G
L
--
L
I
F
-
A
V
---
V
V
L
H
N
G
-------
I
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
---
T
L
-------------------
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
P
V
V
A
V
P
G
-
A
L
F
----
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
-------------
A
----------------------------------
21
Fugue
86.90
16%
-94
- C3 -
4JE5
5
ARO8_YEAST
A:
[5-502]
--------------------------------T
L
P
E
S
K
D
F
S
Y
L
F
S
D
E
T
N
A
R
K
P
S
P
L
K
L
F
Q
D
P
N
I
I
F
L
G
G
G
L
P
L
K
D
Y
-
F
P
W
D
N
L
S
V
D
S
P
K
P
P
F
P
Q
G
I
G
A
P
I
--------
D
E
Q
N
C
I
K
Y
T
V
--
N
K
D
Y
A
D
K
--
S
A
N
P
S
N
-----
D
I
P
L
S
------
R
A
L
Q
Y
G
--
F
S
A
G
Q
P
E
L
L
N
F
I
R
D
H
T
K
I
I
H
D
L
K
Y
K
D
W
D
V
L
A
T
A
G
N
T
N
A
W
E
S
T
L
R
V
F
C
N
R
G
D
V
I
L
V
E
A
H
S
F
S
S
S
L
--
A
S
A
E
A
Q
G
V
I
T
F
P
V
P
I
D
A
D
GI
I
P
E
K
L
A
K
V
M
E
N
W
T
P
G
A
P
------
K
P
K
L
L
Y
T
I
-
P
---
T
G
Q
N
P
T
G
T
S
I
A
D
-------
H
R
K
E
A
I
Y
K
I
A
Q
K
Y
---------
D
F
L
I
V
-----
E
D
E
P
Y
Y
F
L
Q
-----
M
---
N
P
Y
---
I
K
----
D
L
K
E
R
E
K
A
Q
S
S
P
K
Q
D
H
D
E
F
L
K
S
L
A
N
T
F
L
S
L
D
----
T
-
E
G------------------------------
R
V
I
R
M
D
S
F
S
K
V
L
A
P
G
TR
L
G
W
I
T
G
-----------------------------
S
S
K
I
L
K
P
Y
L
S
L
H
E
M
T
I
Q
A
P
---------------
A
G
F
T
------------
Q
V
L
V
N
--
A
T
L
S
R
W
G
--------
Q
K
G
Y
L
D
--------------
W
L
L
G
L
R
H
E
Y
T
L
K
R
D
C
A
I
D
A
L
Y
K
Y
L
--
P
Q
S
D
A
F
---
V
I
N
P
P
I
-------
A
G
M
F
F
T
V
N
I
D
A
S
V
H
P
E
F
K
T
K
Y
NSD
P
Y
-------------------
Q
L
E
Q
S
L
Y
H
K
V
V
E
R
G
V
L
V
V
P
G
S
W
F
K
S
E
G
E
T
E
-
P
P
-----
Q
P
A
E
S
K
E
V
S
N
P
N
I
I
F
F
R
G
-------------
T
Y
A
A
V
S
P
E
K
L
T
E
G
L
K
R
L
G
D
T
L
Y
E
E
F
GIS-------
1
PsiBlast_PDB
83.94
26%
-134
- C3 -
4N7W
2
?
A:
[36-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
-
M
---
L
I
M
F
A
M
G
V
T
L
R
L
-------
D
D
F
K
R
V
L
S
R
P
A
P
V
---
A
A
A
T
F
L
H
Y
L
I
M
-----
P
L
T
A
W
I
L
A
M
-----
L
---
F
R
M
---
P
P
----
D
L
S
A
G
M
V
L
V
G
S
V
A
S
G
T
A
S
N
V
M
I
Y
---
L
A
K
G
D
----
V
-
A
-------------------------------
L
S
V
T
I
S
A
V
S
T
L
V
G
V
F
----
A
T
P
L
-----------------------------
L
T
R
L
Y
-----
V
D
A
-
T
I
S
V
D
V
V
G
M
L
K
S
I
L
Q
I
-
V
V
I
P
I
T
A
------------
G
L
V
I
H
--
H
T
F
T
K
T
V
K
R
I
---
E
P
Y
L
P
A
M
S
--------------
M
V
C
I
L
A
I
I
S
A
-------
V
V
A
G
S
Q
S
--
H
I
A
-
S
V
---
G
F
V
V
I
I
A
V
I
L
H
N
G
I
G
L
L
S
G
Y
W
G
G
K
L
F
G
F
D
E
S
T
C
R
---
T
L
-------------------
A
I
E
V
G
M
Q
N
S
G
L
A
A
T
L
G
K
I
Y
F
S
P
L
A
A
L
P
G
A
L
-
F
S
V
----
W
H
N
L
S
G
S
L
L
A
G
Y
W
S
G
K
P
V
-------------
K
K
D
Q
E
------------------------------
3
PsiBlast_PDB
82.82
26%
-137
- C3 -
4N7X
-
?
A:
[41-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
-
M
---
L
I
M
F
A
M
G
V
T
L
R
L
-------
D
D
F
K
R
V
L
S
R
P
A
P
V
---
A
A
A
T
F
L
H
Y
L
I
M
-----
P
L
T
A
W
I
L
A
M
-----
L
---
F
R
M
---
P
P
----
D
L
S
A
G
M
V
L
V
G
S
V
A
S
G
T
A
S
N
V
M
I
Y
---
L
A
K
G
D
----
V
-
A
-------------------------------
L
S
V
T
I
S
A
V
S
T
L
V
G
V
F
----
A
T
P
L
-----------------------------
L
T
R
L
Y
-----
V
D
A
-
T
I
S
V
D
V
V
G
M
L
K
S
I
L
Q
I
-
V
V
I
P
I
T
A
------------
G
L
V
I
H
--
H
T
F
T
K
T
V
K
R
I
---
E
P
Y
L
P
A
M
S
--------------
M
V
C
I
L
A
I
I
S
A
-------
V
V
A
G
S
Q
S
--
H
I
A
-
S
V
---
G
F
V
V
I
I
A
V
I
L
H
N
G
I
G
L
L
S
G
Y
W
G
G
K
L
F
G
F
D
E
S
T
C
R
---
T
L
-------------------
A
I
A
V
G
M
Q
N
S
G
L
A
A
T
L
G
K
I
Y
F
S
P
L
A
A
L
P
G
A
L
-
F
S
V
----
W
H
N
L
S
G
S
L
L
A
G
Y
W
S
G
K
P
-------------------------------------------------
20
Fugue
80.34
17%
-110
- C2 -
4WRT
2
?
A:
[14-730]
S
M
D
T
F
I
T
R
N
F
Q
T
T
I
I
Q
K
A
K
N
T
M
A
E
F
SEDPELQ
P
A
M
L
F
N
I
C
V
H
L
E
V
C
Y
V
I
S
D
M
N
F
L
D
E
E
G
K
A
Y
T
A
N
--
L
R
P
Q
Y
E
V
I
E
G
M
P
R
T
I
A
W
M
V
Q
R
S
L
A
Q
E
H
G
I
E
T
P
K
YLADLFDY
K
T
K
R
F
I
E
V
G
I
T
K
G
L
A
D
D
Y
F
--
W
K
K
K
E
K
LGNS
M
E
L
M
I
F
S
YNQ
D
Y
S
L
S
N
E
S
S
L
D
E
E
G
K
G
R
V
L
S
R
L
T
E
L
Q
A
E
L
S
L
K
N
L
W
Q
V
L
I
G
E
E
D
-----
V
E
K
G
I
D
F
K
L
G
Q
T
-
I
S
R
L
R
D
I
S
V
P
A
G
F
SN
F
E
G
M
R
S
--
Y
I
D
N
I
D
P
K
G
A
--
I
E
R
N
L
A
R
M
S
P
L
V
S
V
T
P
K
K
L
T
WED
L
R
P
I
G
P
H
I
-
Y
NHE
L
P
E
V
P
Y
N
A
F
L
L
M
SDELGL
A
N
M
T
E
G
K
S
K
K
P
K
T
L
---
A
K
E
C
L
E
K
Y
S
T
L
RDQT
D
P
I
L
I
M
K
S
E
K
AN
E
N
F
L
---
W
K
L
---
W
R
----
D
C
V
N
T
I
S
N
E
E
M
S
N
E
L
Q
K
T
N
Y
A
K
W
---
A
T
G
D
G
----
L
-
T
Y
Q
K
I
M
K
E
V
A
I
D
DETMCQEEPK
I
P
N
K
C
R
V
A
A
W
V
Q
T
E
M
N
L
L
S
T
L
T
S
K
R
----
A
L
D
L
P
E
I
G
PDVA
P
V
E
H
V
G
S
E
R
R
K
Y
F
V
N
E
I
N
Y
C
K
A
S
T
V
M
M
K
Y
V
L
F
H
T
-
S
L
L
N
E
S
N
A
S
M
G
K
Y
K
-
V
-
I
P
I
T
N
R
V
V
N
EKG
E
S
F
D
M
L
Y
G
L
A
V
K
G
Q
S
H
L
R
G
D
T
D
V
V
---
T
V
V
T
F
E
F
S
STDPRVDSGKWPK
Y
T
V
F
R
I
G
S
L
F
V
S
G
R
E
K
S
V
Y
L
Y
C
R
V
N
--
G
T
N
-
K
I
---
Q
M
K
W
G
M
-------
E
A
R
R
C
L
L
Q
S
M
Q
Q
M
E
A
I
V
E
Q
E
S
---
S
I
Q
GYDM
T
K
A
C
F
KGDRVNSPK
T
F
S
I
G
T
Q
E
G
K
L
V
K
G
S
F
G
K
A
L
R
V
I
F
T
K
C
L
M
H
-
Y
V
F
GN
A
Q
L
E
G
F
S
A
E
S
R
R
L
L
L
L
I
Q
A
L
K
D
RKGPWVFD
L
E
G
M
Y
S
G
I
E
E
C
I
SNN
P
W
V
I
Q
S
A
Y
W
F
N
E
W
L
G
F
E
K
E
G
S
K
V
18
Fugue
75.17
15%
-102
- C3 -
1YEW
-
PMOB_METCA
A:
[1-382]
---------------------------------------------------------
H
G
E
K
S
Q
A
A
F
M
R
M
R
T
I
H
W
Y
D
-
L
S
W
S
K
E
K
V
K
----------------------
I
N
E
T
V
E
I
K
G
K
--
F
H
V
F
E
-
G
--
W
P
E
T
V
D
-----
E
P
------------
D
V
A
F
L
N
V
G
M
P
G
P
V
F
I
R
K
E
S
Y
I
G
G
Q
L
V
P
R
S
V
R
L
E
I
G
K
T
Y
D
F
R
V
V
L
K
A
R
R
P
G
D
W
H
V
H
-
T
M
M
N
V
Q
G
G
G
P
I
----------------
I
G
P
G
K
----
W
I
T
V
E
G
S
M
S
E
F
R
-
N
P
V
------
T
T
L
T
---------------
G
Q
T
V
D
L
-------
E
----
N
Y
N
E
G
N
T
Y
---
F
W
H
A
F
W
F
A
I
G
V
-----
A
W
I
G
Y
W
S
R
R
-----
P
---
I
F
I
---
P
R
----
L
L
M
V
D
-------
A
G
R
A
D
E
----
L
---
V
S
A
T
D
----
R
-
K
-------------------------------
V
A
M
G
F
L
A
A
T
I
L
I
V
V
M
----
A
M
S
S
-----------------------------
A
N
S
K
Y
P
I
T
I
P
L
Q
A
-
G
T
M
R
G
M
K
P
L
E
L
P
A
P
-
T
-
V
S
V
K
V
E
-------------
D
A
T
Y
R
--
V
P
G
R
A
M
R
M
K
L
---
T
I
T
N
H
G
N
S
------------------------
P
I
R
L
G
E
F
Y
T
A
S
V
R
F
L
D
S
D
V
-
Y
K
---
D
T
T
G
Y
P
-------
E
D
L
L
A
E
D
G
L
S
V
S
D
N
S
P
L
A
P
G
E
---
T
R
-------------------
T
V
D
V
T
A
S
D
A
A
W
E
V
Y
----
R
L
S
D
I
I
Y
D
P
D
S
R
F
A
G
L
----
L
F
F
F
D
A
T
G
N
R
Q
V
V
Q
I
D
A
P
-------------
L
I
P
S
F
M
-----------------------------
2
PsiBlast_PDB
73.73
29%
-139
- C3 -
3ZUY
7
?
A:
[63-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
K
H
P
K
V
V
---
I
I
G
V
I
A
Q
F
A
I
M
-----
P
A
T
A
W
L
L
S
K
-----
L
---
L
N
L
---
P
A
----
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
---
L
A
R
G
N
----
V
-
A
-------------------------------
L
S
V
A
V
T
S
V
S
T
L
I
S
P
L
----
L
T
P
--------------------------------
A
I
F
--
L
M
L
A
G
E
-
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
K
M
-
V
L
L
P
I
V
L
------------
G
L
I
V
H
--
K
V
L
G
S
K
T
E
K
L
T
D
A
L
P
L
V
S
V
A
A
--------------
I
V
L
I
I
G
A
V
V
G
A
S
K
-
G
K
I
M
E
S
G
L
L
I
--
F
A
V
-
V
V
L
H
N
G
I
------------
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
---
T
L
-------------------
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
P
V
V
A
V
P
G
-
A
L
F
----
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
-------------
A
----------------------------------
4
PsiBlast_PDB
72.63
28%
-139
- C3 -
3ZUX
7
?
A:
[68-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
K
H
P
K
V
V
---
I
I
G
V
I
A
Q
F
A
I
M
-----
P
A
T
A
W
C
L
S
K
-----
L
---
L
N
L
---
P
A
----
E
I
A
V
G
V
I
L
V
G
C
C
P
G
G
T
A
S
N
V
M
T
Y
---
L
A
R
G
N
----
V
-
A
-------------------------------
L
S
V
A
V
T
S
V
S
T
L
T
S
P
L
----
L
T
P
--------------------------------
A
I
F
--
L
M
L
A
G
E
-
M
L
E
I
Q
A
A
G
M
L
M
S
I
V
K
M
-
V
L
L
P
I
V
L
------------
G
L
I
V
H
--
K
V
L
G
S
K
T
E
K
L
T
D
A
L
P
L
V
S
V
A
A
--------------
I
V
L
I
I
G
A
V
V
G
A
S
K
-
G
K
I
M
E
S
G
L
L
I
--
F
A
V
-
V
V
L
H
N
G
I
------------
G
Y
L
L
G
F
F
A
A
K
W
T
G
L
P
Y
D
A
Q
K
---
A
L
-------------------
T
I
E
V
G
M
Q
N
S
G
L
A
A
A
L
A
A
A
H
F
A
A
A
P
V
V
A
V
P
G
-
A
L
F
----
S
V
W
H
N
I
S
G
S
L
L
A
T
Y
W
A
A
K
-------------
A
----------------------------------
16
Fugue
39.90
15%
308
- C3 -
2K7W
-
B:
[1-20]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
W
I
A
Q
E
L
R
R
I
G
D
E
F
N
A
Y
-
Y
A
-----------------------------------------------------------------------
5
HHSearch
37.85
21%
-77
- C3 -
1ZCD
-
NHAA_ECOLI
A:
[256-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
W
V
------
A
Y
L
I
L
P
L
F
A
F
---
A
N
---
A
G
V
S
L
Q
G
-------
V
T
L
D
G
L
-
T
-
S
I
L
P
---
L
G
I
I
A
G
L
L
I
G
K
-----
P
L
G
I
S
L
F
C
W
-----
L
ALR
L
K
L
AHL
P
E
GTTY
Q
Q
I
M
V
V
G
-
I
L
C
G
I
G
F
T
M
S
I
F
I
A
S
---
L
A
F
G
S
VDPE
L
I
N
-------------------------------
W
A
K
L
G
I
L
V
G
S
I
S
S
A
V
----
I
G
Y
S
-----------------------------
W
L
R
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
35.61
14%
118
* C3 *
1DEB
-
APC_HUMAN
A:
[1-54]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
Y
D
Q
L
L
-
K
Q
V
E
A
L
K
M
E
N
S
N
L
--
R
Q
E
L
E
D
--
N
S
N
H
L
T
K
L
E
T
--
E
A
S
N
M
K
E
V
L
K
Q
L
Q
G
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
33.13
28%
73
- C3 -
1IIJ
-
A:
[1-35]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
R
A
S
-
P
V
T
F
I
I
A
T
V
V
G
V
L
L
-
F
-
L
I
L
V
V
V
V
------------
G
I
L
I
K
--
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
33.05
25%
64
- C3 -
2JWA
-
ERBB2_HUMAN
A:
[41-84]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
P
A
E
Q
R
A
S
-
P
L
T
S
I
I
S
A
V
V
G
I
L
L
-
V
-
V
V
L
G
V
V
F
------------
G
I
L
I
K
--
R
R
Q
Q
K
I
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
30.63
29%
-91
* C4 *
1PJ3
3
MAOM_HUMAN
A:
[105-141]
-----------------------------------------------------------------------------------------------
H
I
F
R
R
--------
P
K
G
L
F
I
S
I
S
D
R-
G
H
V
R
S
I
V
D
N
W
P
E
N
H
V
-----
K
A
V
V
V
------
T
D
G
E
R
I
L
G
L
G
D
L
G
V
Y
G
M
G
I
P
V
G
K
L
C
L
Y
T
A
C
A
G
I
R
P
D
R
C
L
P
V
C
I
D
V
G
T
D
N
I
A
L
L
K
D
P
F
Y
-
M
G
L
Y
Q
K
R
D
R
T
Q
Q
Y
--
D
D
L
I
D
E
--
F
M
K
A
I
T
D
R
Y
G
--
R
N
T
L
I
Q
F
E
D
F
G
N
H
N
A
F
R
------
F
L
R
K
Y
R
E
K
-
Y
---
C
T
F
N
D
D
I
Q
G
T
A
A
-------
V
A
L
A
G
L
L
A
A
Q
K
V
I
---
S
K
P
I
S
E
H
K
I
L
F
-----
L
G
A
G
E
A
A
L
G
-----
I
---
A
N
L
---
I
V
----
M
S
M
V
E
N
G
L
S
E
Q
E
A
Q
K
K
I
W
M
F
D
K
Y
---
G
L
L
V
K
----
G
-
R
-------------------------------
K
A
K
I
D
S
Y
Q
E
P
F
T
H
S
A
----
P
E
S
I
-----------------------------
P
D
T
F
E
D
A
V
N
I
L
K
P
-
S
T
I
I
G
V
A
G
A
G
R
L
F
T
-
P
-
D
V
I
R
A
M
A
------------
S
I
N
E
R
--
P
V
I
F
A
L
S
N
P
T
---
A
Q
A
E
C
T
A
E
--------------
E
A
Y
T
L
T
E
G
R
C
L
F
A
S
G
S
P
F
G
P
V
K
L
T
--
D
G
R
-
V
F
---
T
P
G
Q
G
N
-------
N
V
Y
I
F
P
G
V
A
L
A
V
I
L
C
N
T
R
H
I
S
---
D
S
-------------------
V
F
L
E
A
A
K
A
L
T
S
Q
L
T
D
E
E
L
A
Q
G
R
L
Y
P
P
L
A
N
I
-
Q
E
V
----
S
I
N
I
A
I
K
V
T
E
Y
L
Y
A
N
K
M
A
-------------
F
R
Y
P
E
P
E
D
K
--------------------------
13
HHSearch
26.15
24%
-71
- C4 -
1GQ2
-
MAOX_COLLI
A:
[103-139]
-----------------------------------------------------------------------------------------------
L
A
F
R
R
--------
P
R
G
L
F
I
T
I
H
D
R-
G
H
I
A
T
M
L
Q
S
W
P
E
S
V
I
-----
K
A
I
V
V
------
T
D
G
E
R
I
L
G
L
G
D
L
G
C
Y
G
M
G
I
P
V
G
K
L
A
L
Y
T
A
C
G
G
V
K
P
H
Q
C
L
P
V
M
L
D
V
G
T
D
N
E
T
L
L
K
D
P
L
Y
-
I
G
L
R
H
K
R
I
R
G
Q
A
Y
--
D
D
L
L
D
E
--
F
M
E
A
V
T
S
R
Y
G
--
M
N
C
L
I
Q
F
E
D
F
A
N
A
N
A
F
R
------
L
L
H
K
Y
R
N
K
-
Y
---
C
T
F
N
D
D
I
Q
G
T
A
S
-------
V
A
V
A
G
L
L
A
A
L
R
I
T
---
K
N
R
L
S
D
H
T
V
L
F
-----
Q
G
A
G
E
A
A
L
G
-----
I
---
A
N
L
---
I
V
----
M
A
M
Q
K
E
G
V
S
K
E
E
A
I
K
R
I
W
M
V
D
S
K
---
G
L
I
V
K
----
G
-
R
-------------------------------
A
S
L
T
P
E
K
E
H
F
A
H
E
H
C
----
E
M
K
N
-----------------------------
L
E
D
I
V
K
D
I
K
P
T
V
L
-
I
G
V
A
A
I
G
G
A
F
T
Q
Q
I
-
L
-
Q
D
M
A
A
F
N
------------
K
R
P
I
I
--
F
A
L
S
N
P
T
S
K
A
---
E
C
T
A
E
Q
L
Y
--------------
K
Y
T
E
G
R
G
I
F
A
S
G
S
P
F
D
P
V
T
L
P
S
G
Q
--
T
L
Y
-
P
G
---
Q
G
N
N
S
Y
-------
V
F
P
G
V
A
L
G
V
I
S
C
G
L
K
H
I
G
D
D
V
---
F
L
-------------------
T
T
A
E
V
I
A
Q
E
V
S
E
E
N
L
Q
E
G
R
L
Y
P
P
L
V
T
I
Q
Q
V
-
S
L
K
----
I
A
V
R
I
A
K
E
A
Y
R
N
N
T
A
S
T
Y
-------------
P
Q
P
E
D
L
E
A
F
--------------------------
7
HHSearch
23.98
21%
-32
- C3 -
1ZCD
-
NHAA_ECOLI
A:
[70-114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
F
L
L
V
G
L
E
V
K
R
-------
E
L
M
Q
G
S
L
A
S
L
R
Q
A
A
F
P
V
I
A
A
I
G
G
M
-
I
V
-----
P
A
L
L
Y
L
A
F
N
-----
Y
---
A
D
P
---
I
T
----
R
E
G
W
A
I
P
A
A
T
D
I
A
F
A
L
G
V
L
A
L
L
G
---
S
R
V
P
L
----
A
-
L
-------------------------------
K
I
F
L
M
A
L
A
I
I
D
D
L
G
A
----
I
I
I
I
-----------------------------
A
L
F
Y
T
N
D
L
S
M
A
S
L
-
G
V
A
A
V
A
I
A
V
L
A
V
L
N
-
L
-
C
G
A
R
R
T
G
------------
V
Y
I
L
V
--
G
V
V
L
W
T
A
V
L
K
---
S
G
V
H
A
T
L
A
--------------
G
V
I
V
G
F
F
I
P
L
K
E
K
H
G
R
S
P
A
K
R
L
E
H
--
V
L
H
-
P
W
---
V
A
Y
L
I
L
-------
P
L
F
A
F
A
N
A
G
V
S
L
Q
G
V
T
L
D
G
L
T
---
S
I
-------------------
L
P
L
G
I
I
A
G
L
L
I
G
K
P
L
G
I
S
L
F
C
W
L
A
L
R
L
K
L
A
-
H
L
P
----
E
G
T
T
Y
Q
Q
I
M
V
V
G
I
L
C
G
I
G
-------------
F
T
M
S
I
F
I
A
S
--------------------------
14
HHSearch
22.41
27%
301
- C5 -
2W0C
-
SPIKE_BPPM2
L:
[252-278]
---------------------------------------------------------------------------------------------------------------
K
Y
T
S
Y
G
S
T-
G
S
H
S
G
Y
D
--
F
D
D
N
T
L
-----
D
V
M
V
T
------
L
S
A
G
V
H
R
V
F
P
V
E
T
E
L
D
Y
D
A
V
Q
E
V
Q
H
D
W
Y
D
E
S
F
T
T
F
I
E
V
Y
S
D
D
P
L
L
T
V
K
G
Y
A
Q
I
L
M
E
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
20.03
27%
299
* C5 *
2VVE
-
SPIKE_BPPM2
A:
[171-197]
---------------------------------------------------------------------------------------------------------------
K
Y
T
S
Y
G
S
T
-
G
S
H
S
G
Y
D
--
F
D
D
N
T
L
-----
D
V
M
V
T
------
L
S
A
G
V
H
R
V
F
P
V
E
T
E
L
D
Y
D
A
V
Q
E
V
Q
H
D
W
Y
D
E
S
F
T
T
F
I
E
V
Y
S
D
D
P
L
L
T
V
K
G
Y
A
Q
I
L
M
E
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
18.15
43%
2791
- C1 -
1ANS
-
STX3_ANESU
A:
[20-26]
----------------------------------------------------------
E
G
C
S
G
P
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------