@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PCFT_HUMAN: (2015-12-08 )
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Atome Classification :
(20 SA)
.........10........20........30.........40........50.------.......60........70........80.-------.......90........------100.......110.......120--------------..---.--------....130..--------------.....-.140........150..--------------...--..160.......-----170------------------------.......180.-....------------..-190-....------...200..--------------------------.-....210.......----220....-...230....-.-..240-.........250.-------......260--.........270-------....-------....280.......---290-.......---..300....---...310.--.-.....-320.------......330---.....-...---340---.........350------.---.-......360......-.370---........380.......390...-....400..-.....410.......420--.........430.......440.......450.......----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGSASPPEKPRARP
A
A
A
V
L
CRGPV
E
P
L
V
F
-
L
A
N
F
A
L
VLQGP
L
T
T
Q
Y
L
W
H
R
FS------ADLGYNGTRQRGGCSNRSAD
P
T
M
Q
E
V
E
T
L
T
-------SH
W
T
L
Y
M
NV
G
G
F
L
V
G
L
F
------
S
S
T
L
L
G
AWSDSVGRR
P
L
L
V
L
A
S
L
--------------
G
L
---
L
--------
L
Q
A
L
V
S
-
V
F
--------------
V
V
Q
L
Q
-
L
H
-
V
G
Y
F
V
L
G
R
I
L
C
A
L
L
--------------
G
D
F
--
G
G
L
L
A
A
S
F
A
S
V
A
-----DVS------------------------SSRS
R
T
F
R
M
A
L
-
L
E
A
S
------------
I
G
-
V
A
G
-
M
L
A
S
------
L
LGG
H
W
L
R--------------------------A-QGYA
N
P
F
W
L
A
L
A
L
L
----
I
A
M
T
L
Y
A
-
A
F
C
F
G
E
T
LKE-P-KST---
R
L
F
T
F
R
H
H
R
S
I
V
Q
-------
L
Y
VAPAP----EKSR
K
H
L
A
L
Y
S
--------
L
A
I
F
-------
V
V
I
T
V
HFG
A
Q
D
I
L
T
---
L
---
Y
ELSTPL---CWDSKLIGY---G
S
A
A
Q
H
L
--
P
-
Y
L
T
S
L
-
L
A
L
K
------
L
L
Q
Y
C
L
A
-
D
---
A
W
V
A
E
-
I
G
L
---
A
-----
F
N
I
L
G
M
V
V
F
A
-
F
------
A
---
T
-
I
T
P
L
M
F
T
G
Y
G
L
L
F
L
S
-
L
V
I
----
T
P
V
I
R
A
K
L
S
K
L
V
R
E
T
EQ
G
A
L
F
S
A
V
-
A
C
V
N
S
L
A
M
L
-
T
A
S
G
I
F
NSL
Y
P
A
T
L
N
F
----MKG
F
P
F
L
LG
A
G
L
L
L
I
P
A
V
L
I
G
M
L
EKADPH
L
E
F
Q
QFPQSP----------------------------------------------
23
Fugue
79.23
15%
-105
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
-
F
G
Y
D
T
A
V
I
S
G
--
T
V
E
S
L
N
T
V
F
V
------
A
P
Q
N
L
S
-----------------
E
S
A
A
N
S
L
-------
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
------
L
G
G
Y
C
S
N
R
F
---
G
R
R
D
S
L
K
I
A
A
V
--------------
L
F
---
F
--------
I
S
G
V
G
S
-
A
W
PELGFTSINPDNTV
P
V
Y
L
A
-
G
Y
-
V
P
E
F
V
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Y
R
I
I
G
G
I
G
--------------
V
G
L
--
A
S
M
L
S
P
M
Y
I
A
-------
E
L
A
------------------------
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
------------
I
I
-
F
G
Q
-
L
L
V
Y
------
C
V
N
Y
F
I
A
R
--------------------------
S
-
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
----
F
A
S
E
C
I
P
-
A
L
L
F
L
M
L
L
Y
T
V
P
-
E
S
P
---
R
W
L
M
S
R
G
K
Q
E
Q
A
E
-------
G
I
L
R
K
I
M
----
G
N
T
L
A
T
Q
A
V
Q
E
--------
I
K
H
S
-------
L
D
H
G
R
K
T
G
G
R
L
L
M
F
GVG
V
---
I
V
I
G
V
M
L
---
S
I
F
Q
Q
F
V
G
I
---
N
V
V
L
Y
Y
A
--
P
-
E
V
F
K
T
-
L
G
A
S
------
T
D
I
A
L
L
Q
-
T
---
I
I
V
G
V
-
I
N
L
---
T
-----
F
T
V
L
A
I
M
T
V
D
-
K
------
F
---
G
-
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
-
M
F
S
----
L
G
T
A
F
Y
T
-----
Q
A
P
G
I
V
A
L
L
S
M
L
-
F
Y
V
A
A
F
A
M
---------
S
W
G
P
V
C
W
V
L
----
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
FHNG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFVPETKGKTLEELEALWE
20
Fugue
78.91
19%
-119
- C1 -
5AWO
-
?
A:
[15-610]
-
P
V
T
A
A
P
P
L
R
L
A
S
R
N
S
--
V
F
T
R
S
G
A
G
P
R
Y
W
N
I
Y
G
Y
S
F
P
H
N
A
P
I
P
E
N
E
W
K
V
N
I
D
W
L
A
G
NF
A
D
F
G
Y
D
I
A
C
T
D
G
W
I
E
G
S
S
R
T
T
G
N
G
Y
I
T
S
Y
N
DSWQHD
W
A
Y
W
A
N
Y
L
A
A
R
K
M
K
L
G
V
Y
Y
N
PLWV
H
R
A
A
V
E
D
A
S
K
T
V
L
G
R
P
D
V
K
I
A
D
L
VVPGDFFARDIGGN
Q
L
---
Y
WLDVTKSG
A
K
E
Y
V
Q
-
G
Y
--------------
V
R
Y
F
K
D
L
G
-
V
P
Y
L
R
I
D
-
F
L
S
W
Y
E
DGRDANIGQVNAPH
G
R
A
--
N
Y
E
L
A
L
S
W
I
N
E
A
A
GED
M
E
V
S
L
VPHMFQDG
S
A
E
L
A
NGDLVRINAD
A
D
K
G
G
W
D
R
L
S
G
-
M
R
Q
N
WQDAWPNWAN
P
F
C
G
-
F
T
G
-
W
S
H
R
NGRG
Q
L
I
L
D
G
D
F
M
R
--------------------------
A
-
S
T
F
A
S
D
E
E
R
K
T
M
M
N
----
L
M
V
A
A
G
S
-
P
L
A
I
A
D
T
Y
Q
Q
-
I
G
N
N
A
---
W
V
Y
T
N
K
E
V
L
Q
L
N
A
D
G
L
V
G
K
P
L
Y
R
S
A
T
P
FSKD
P
G
S
R
D
T
E
R
W
A
G
Q
L
PDG
S
W
G
V
A
L
F
N
RSD
T
E
T
V
T
K
T
I
D
F
-
A
K
D
L
G
L
---
A
---
T
G
G
N
V
R
D
---
L
W
E
H
R
N
L
G
M
---
D
S
R
A
T
A
A
LA
P
-
H
A
S
A
I
-
F
R
V
T
P
P
K
M
HG
T
T
R
Y
P
A
A
F
A
---
A
W
G
G
G
-
A
G
F
---
N
-----
Y
N
H
P
G
Y
D
G
N
G
-
F
------
V
---
D
G
L
Q
A
G
S
G
S
A
D
P
L
V
T
F
A
-
V
Q
V
P
H
R
G
S
Y
A
I
R
Y
R
Y
A
-----
N
A
T
G
D
T
S
T
M
T
-
V
T
A
E
K
A
D
R
S
-
T
V
D
G
P
V
H
V
S
F
P
G
L
A
T
W
D
T
W
G
V
A
D
G
T
I
T
L
D
A
G
L
N
L
---
V
T
I
G
R
G
A
T
D
K
G
A
I
N
L
N
W
I
E
L
D
M
----------------------------------------------
22
Fugue
78.90
18%
-109
- C2 -
3WDO
-
?
A:
[1-453]
-----
D
Y
K
M
T
P
G
E
R
R
A
T
W
G
L
--
G
T
V
F
S
L
R
M
-
L
G
M
F
M
V
L
---
P
V
L
T
T
Y
------------------
G
M
A
L
Q
G
--------
A
S
E
A
L
I
G
I
A
I
-------
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
------
S
D
R
--------
I
G
R
K
P
L
I
V
G
G
L
A
--------------
V
F
---
A
--------
A
G
S
V
I
A
-
A
L
------------------
S
-
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
--------------------
G
A
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A
A
A
V
M
A
L
L
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-----
D
L
T
------------------------
R
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A
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------------
F
G
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A
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A
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------
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L
G
P
I
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H
--------------------------
K
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L
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L
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A
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W
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M
V
K
G
S
F
S
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V
L
-----------
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P
----
R
L
L
K
L
N
F
G
I
M
C
--------
L
H
M
L
-------
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
---
A
GFP
A
A
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H
W
K
V
---
Y
L
A
T
M
L
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A
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---
G
S
V
V
P
F
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Y
A
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V
K
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K
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Q
------
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C
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L
---
I
V
V
A
E
-
I
V
L
---
W
N
AQTQ
F
W
Q
L
V
V
G
V
Q
L
-
F
------
F
---
V
-
A
F
N
L
M
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A
L
L
P
S
L
I
S
K
-
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S
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----
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
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L
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G
W
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D
G
M
F
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D
G
Q
G
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F
L
A
G
A
M
L
A
A
V
W
----
L
A
V
A
S
T
M
K
E
P
P
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V
S
S
L
R
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A
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A
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L
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L
L
E
T
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VK
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AEEEH
S
A
Y
V
K
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DSKVTN
R
F
E
V
E
Q
A
I
R
QAL-----------
21
Fugue
72.81
14%
-111
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
----
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
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F
L
G
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F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
------
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Y
L
V
E
Q
G
---------------------
F
S
-------
R
G
D
L
G
F
A
L
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G
I
S
I
A
Y
G
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------
S
K
F
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M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
--------------
L
A
---
A
--------
A
V
M
L
F
M
-
G
F
--------------
V
P
W
A
T
-
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
--------------
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M
--
G
--
W
P
P
C
G
R
T
M
V
-----
H
W
W
------------------------
S
Q
K
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G
G
I
V
S
V
-
W
N
C
A
------------
H
N
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V
G
G
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G
I
P
P
------
L
L
F
L
L
G
M
A
--------------------------
W
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F
N
D
W
H
A
A
L
Y
M
P
A
F
C
----
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L
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K
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-------
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----
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L
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N
K
L
L
W
Y
I
A
--------
I
A
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-------
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L
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Y
G
I
L
D
W
S
P
---
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-
L
K
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---
H
F
A
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D
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S
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---
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Y
F
L
Y
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--
A
-
G
I
P
G
T
-
L
L
C
G
------
W
M
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D
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---
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N
R
G
A
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T
G
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---
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-----
F
M
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L
V
T
I
A
T
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-
V
Y
W
M
NPA
G
---
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
-
Y
G
P
----
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
-----
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------
18
Fugue
71.99
13%
-118
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-----------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
-
I
P
A
I
A
D
M
A
------------------------------------
R
D
L
N
V
R
E
G
A
V
Q
S
V
M
-------
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
--------------
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
--------------
I
F
---
M
--------
L
A
T
L
V
A
-
V
T
--------------
T
S
S
L
T
------
V
L
I
A
A
S
A
M
Q
G
M
G
--------------
T
G
V
--
G
G
V
M
A
R
T
L
P
R
D
L
-----
Y
E
R
------------------------
T
Q
L
R
H
--
A
N
S
L
-
L
N
M
G
------------
I
L
-
V
S
P
-
L
L
A
P
------
L
I
G
G
L
L
D
T
--------------------------
M
-
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
----
A
G
V
T
F
S
M
-
A
R
W
M
P
E
T
R
P
V
-
D
-
A
P
-----------
R
T
R
L
L
T
-------
S
Y
K
T
L
F
G
----
N
S
G
F
N
C
Y
L
L
M
L
--------
I
G
G
L
-------
A
G
I
A
A
F
E
A
C
S
G
V
L
M
---
G
-------------------
A
V
L
---
G
L
S
S
M
T
V
--
S
-
I
L
F
I
L
-
P
I
P
A
------
A
F
F
G
A
W
F
-
A
---
G
R
P
N
K
-
R
F
S
---
T
-----
L
M
W
Q
S
V
I
C
C
L
-
L
------
A
---
G
--
L
L
M
W
I
P
D
W
F
G
V
M
N
V
-
W
T
L
----
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
-
P
F
P
F
L
A
G
T
A
-
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
----
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
-----------------------------------------------------
7
HHSearch
69.79
15%
-128
- C2 -
3WDO
-
?
A:
[9-382]
------------------
R
R
A
T
W
G
L
G
T
V
F
S
-
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
----------
G
A
S
----------------
E
A
L
I
---------------
G
I
A
I
G
I
Y
G
L
T
Q
A
V
------
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
--------------
V
F
---
A
--------
A
G
S
V
I
A
-
A
------------------
L
S
-
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
--------------
A
------
I
A
A
A
V
M
A
L
L
S
-----
D
L
T
------------------------
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
------------
F
G
-
I
T
F
-
A
I
A
M
------
V
L
G
P
I
I
T
H
--------------------------
K
-
L
G
L
H
A
L
F
W
M
I
A
I
L
A
----
T
T
G
I
A
L
T
-
I
W
V
V
P
N
S
S
T
H
-
V
-
L
N
R
---
E
S
G
--
M
V
K
G
S
F
S
K
-------
V
-----------
L
A
E
P
R
L
L
K
L
N
--------
F
G
I
M
-------
C
L
H
M
L
L
M
S
T
F
V
A
L
P
---
G
---
Q
L
-
A
D
-
A
---
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
--
G
S
V
V
P
F
I
-
I
Y
A
E
------
V
K
R
K
-
M
K
-
Q
-----
V
F
V
-
F
C
V
---
G
-----
L
I
V
V
A
E
I
V
L
W
N
A
------
Q
---
T
-
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
----
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-------
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
----------------------------------------------
8
HHSearch
67.19
14%
-119
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[32-421]
-------------------------
C
S
L
F
F
-
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
-----------
F
T
L
T
----------------
N
F
Q
A
G
---------------
L
I
Q
S
A
F
Y
F
G
Y
F
I
------
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
--------------
L
Y
---
A
--------
L
G
A
A
L
F
-
W
P
--------------
A
A
-
E
I
-
M
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
--------------
L
----
G
C
L
E
T
A
A
N
P
F
V
T
-----
V
L
G
------------------------
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
------------
N
S
-
F
G
A
-
I
I
A
V
------
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
-
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
----
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
-
N
-
H
-----
S
D
A
---
K
Q
G
S
F
S
A
-------
S
L
---
S
R
----
L
A
R
I
R
H
W
R
W
A
V
--------
L
A
Q
F
-------
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
---
R
---
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
---
Y
L
T
G
T
M
V
--
C
F
F
I
G
R
F
-
T
G
T
W
------
L
I
S
R
-
F
A
-
P
---
H
K
V
L
A
-
A
Y
A
---
L
-----
I
A
M
A
L
C
L
I
S
A
-
F
------
A
---
G
-
G
H
V
G
L
-
I
A
L
T
L
C
S
A
F
M
S
I
Q
----
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
------
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------
9
HHSearch
64.98
16%
-116
- C2 -
2GFP
-
EMRD_ECOLI
A:
[15-360]
--------------------------
L
L
V
A
-
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
L
-----------
N
V
R
----------------
E
G
A
V
---------------
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
------
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
M
S
--------------
I
F
---
M
--------
L
A
T
L
V
A
-
V
------------------
T
T
-
S
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
--------------
T
----
G
V
G
G
V
M
A
R
T
L
P
R
-----
D
L
Y
------------------------
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
------------
I
L
-
V
S
P
-
L
L
A
P
------
L
I
G
G
L
L
D
T
--------------------------
M
-
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
----
A
G
V
T
F
S
M
-
A
R
W
M
P
E
T
R
P
V
-
D
-
A
P
R
---
T
----
R
L
L
T
S
Y
K
T
-------
L
-----------
F
G
N
S
G
F
N
C
Y
L
--------
L
M
L
I
-------
G
G
L
A
G
I
A
A
F
E
A
C
S
G
---
V
---
L
M
-
G
A
V
L
---
G
L
S
S
M
T
V
S
I
---
L
F
I
L
P
I
P
--
A
A
F
F
G
A
W
-
F
A
G
R
------
P
N
K
R
-
F
S
-
T
---
L
M
W
Q
S
V
I
C
C
---
L
-----
L
A
G
L
L
M
W
I
P
D
-
W
------
F
G
V
-
M
-
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
----
F
P
L
A
T
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
I
G
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
----
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------------------------------------------------
17
Fugue
63.73
10%
-113
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
-
P
I
W
L
H
D
I
N
H
-----------------------------------------------
I
S
-------
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
------
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
--------------
G
M
---
L
--------
V
M
F
A
P
F
-
F
I
--------------
F
I
F
G
P
-
L
L
-
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
--------------
L
G
F
--
C
F
N
A
G
A
P
A
V
E
A
F
-----
I
E
K
------------------------
V
S
R
R
S
N
F
E
F
G
R
-
A
R
M
F
------------
G
C
-
V
G
W
-
A
L
G
A
------
S
I
V
G
I
M
F
T
--------------------------
I
--
N
N
Q
F
V
F
W
L
G
S
G
C
A
----
L
I
L
A
V
L
L
-
F
F
A
K
T
D
A
P
S
S
-
A
-
T
V
A
---
N
A
V
G
A
N
H
S
A
F
S
L
K
-------
L
A
L
E
L
F
R
-------
Q
P
K
L
W
F
L
S
--------
L
Y
V
I
-------
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
---
N
---
F
-
F
T
S
F
F
---
A
T
G
E
Q
G
T
R
V
---
F
G
Y
V
T
T
M
--
G
-
E
L
L
N
A
-
S
I
M
F
------
F
A
P
L
I
I
N
-
R
I
G
G
K
N
A
L
L
-
L
A
G
---
T
-----
I
M
S
V
R
I
I
G
S
S
-
F
------
A
T--
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
-
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
----
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------
10
HHSearch
63.08
13%
-117
- C2 -
2CFQ
-
LACY_ECOLI
A:
[7-393]
-------------------
T
N
F
W
M
F
G
L
F
F
F
-
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
----------
H
I
S
----------------
K
S
D
T
---------------
G
I
I
F
A
A
I
S
L
F
S
L
L
------
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
--------------
G
M
L
V
M
F
--------
A
P
F
F
I
F
-
I
------------------
F
G
-
P
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
--------------
L
G
F
CF
N
A
G
A
P
A
V
E
A
F
I
E
-----
K
V
S
------------------------
R
--
R
S
N
F
E
F
G
R
-
A
R
M
F
------------
G
C
-
V
G
W
-
A
L
G
A
------
S
I
V
G
I
M
F
T
----------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
----
L
I
L
A
V
L
L
--
F
F
A
K
T
D
A
P
S
-
S
-
A
T
V
---
A
N
A
V
--
G
A
N
H
S
A
F
-------
S
L
K
L
A
L
E
----
L
F
R
Q
P
K
L
W
F
L
S
--------
L
Y
V
I
-------
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
---
N
---
F
F
-
T
S
F
F
AT
G
E
Q
G
T
R
V
F
G
Y
---
V
T
T
M
G
E
L
--
L
N
A
S
I
M
F
-
F
A
P
L
------
I
I
N
R
-
I
G
-
G
---
K
N
A
L
L
-
L
A
G
---
T
-----
I
M
S
V
R
I
I
G
S
S
-
F
------
A
---
T
-
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
-------
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
----------------------------------------------
6
HHSearch
58.26
13%
-127
* C2 *
1PW4
-
GLPT_ECOLI
A:
[66-431]
----------------------------------------------------------------------------------------------------
G
F
A
L
S
G
I
S
I
A
Y
G
F
------
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
--------------
L
A
---
A
--------
A
V
M
L
F
M
-
G
F
--------------
V
P
W
A
T
-
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
--------------
Q
----
G
M
G
W
P
P
C
G
R
T
M
V
-----
H
W
W
------------------------
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
C
A
------------
H
N
-
V
G
G
-
G
I
P
P
------
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
----
I
L
V
A
L
F
A
-
F
A
M
M
R
D
T
P
Q
S
-
C
-
G
L
P
PIE
E
Y
K
N
D
----
T
A
K
Q
-------
I
F
M
--
Q
Y
----
V
L
P
N
K
L
L
W
Y
I
A
--------
I
A
N
V
-------
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
---
T
---
Y
L
-
K
E
V
K
---
H
F
A
L
D
K
S
S
W
---
A
Y
F
L
Y
E
Y
--
A
G
I
P
G
T
L
-
L
C
G
W
------
M
S
D
K
-
V
F
-
R
---
G
N
R
G
A
-
T
G
V
F
F
M
T
-----
L
V
T
I
A
T
I
V
Y
W
-
M
------
N
PA-
G
-
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
----
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
-------
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
----------------------------------------------
11
HHSearch
48.65
17%
-126
- C2 -
3WDO
-
?
A:
[10-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
T
W
G
L
G
--------
T
V
F
S
-------
L
R
M
L
G
M
F
M
V
L
P
V
L
T
---
T
---
Y
G
-
M
A
L
Q
---
G
A
S
E
A
L
I
G
I
---
A
I
G
I
Y
G
L
--
T
Q
A
V
F
Q
I
-
P
F
G
L
------
L
S
D
R
-
I
G
-
R
---
K
P
L
I
V
-
G
G
L
---
A
-----
V
F
A
A
G
S
V
I
A
A
-
L
------
S
---
D
-
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
-
A
-
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
-------
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
----------------------------------------------
1
PsiBlast_PDB
44.64
33%
-123
- C2 -
3WDO
-
?
A:
[67-182]
----------------------------------------------------------------------------------------------------------------------------
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
-----------------
G
L
---
A
--------
V
F
A
A
G
S
-
V
---------------
I
A
A
L
S
-
D
S
-
I
W
G
I
I
L
G
R
---
A
L
Q
--------------
G
S
---
G
A
I
A
A
A
V
M
A
L
L
S
-----
D
L
T
------------------------
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
------------
F
G
-
I
T
F
-
A
I
A
M
------
V
L
G
P
I
I
T
H
--------------------------
K
-
L
G
L
H
A
L
F
W
M
-
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
-
V
P
N
S
S
T
H
V
L
N
-
R
-
E
S
G
---
M
V
K
G
S
F
S
K
V
L
A
E
P
-------
R
L
L
K
L
N
F
----
G
I
M
C
L
H
M
L
L
M
S
--------
T
F
V
A
-------
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
---
H
---
W
K
V
Y
L
A
T
---
M
L
I
A
F
G
S
V
V
---
P
F
I
I
Y
A
E
--
V
-
K
R
K
M
K
-
Q
V
F
V
------
F
C
V
G
L
I
V
-
V
---
A
E
I
V
L
-
W
N
A
---
Q
-----
T
Q
F
W
Q
L
V
V
G
V
-
Q
------
L
---
F
-
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
-
S
K
E
----
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
-
G
S
L
G
G
W
I
D
G
-
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
----
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
----------------------------------------------
4
PsiBlast_PDB
42.74
27%
-120
- C2 -
4ZP0
1
?
A:
[57-172]
--------------------------------------------------------------------------------------------------------------
G
M
F
------
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
----
L
--------------
A
G
---
V
--------
V
W
F
I
V
T
-
C
L
--------------
A
I
L
L
A
-
Q
N
-
I
E
Q
F
T
L
L
R
F
L
Q
G
I
S
--------------
L
C
F
--
I
G
--
A
V
G
Y
A
A
I
R
-----
E
-
S
------------------------
F
E
E
A
V
C
I
K
I
T
A
-
L
M
A
N
------------
V
A
L
I
A
P
-
L
L
G
P
------
L
V
G
A
A
W
I
H
--------------------------
V
-
L
P
W
E
G
M
F
V
L
F
A
A
L
A
----
A
I
S
F
F
G
L
-
Q
R
A
M
P
E
T
A
T
R
-
I
-
G
E
K
---
L
S
L
K
E
L
G
R
D
Y
K
L
V
-------
L
K
N
G
R
F
V
----
A
G
A
L
A
L
G
F
V
S
L
--------
P
L
L
A
-------
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
---
L
---
S
S
Y
E
Y
G
L
---
L
Q
V
P
I
F
G
A
L
---
I
A
G
N
L
L
L
--
A
-
R
L
T
S
R
-
R
T
V
R
------
S
L
I
I
M
G
G
-
W
---
P
I
M
I
G
-
L
L
V
---
A
-----
A
A
A
T
V
I
S
S
H
A
-
Y
------
L
---
W
-
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
-
N
A
G
----
L
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
-
M
L
I
F
T
V
G
I
E
-
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
----
F
N
L
V
N
G
I
L
W
L
S
L
M
V
I
F
L
K
-------------------------------------------------------------------
13
HHSearch
41.63
15%
-120
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[37-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
A
V
A
N
N
L
N
D
I
L
L
P
---
Q
---
F
Q
--
Q
A
F
---
T
L
T
N
F
Q
A
G
L
---
I
Q
S
A
F
Y
F
--
G
Y
F
I
I
P
I
-
P
A
G
I
------
L
M
K
K
-
L
S
-
Y
---
K
A
G
I
I
-
T
G
L
---
F
-----
L
Y
A
L
G
A
A
L
F
W
-
P
------
A
A
E
I
M
-
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
----
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
----------------------------------------------
14
HHSearch
41.37
14%
-103
- C2 -
1PW4
-
GLPT_ECOLI
A:
[293-431]
-----------------------------------------------------------------------------------------------------
W
A
Y
F
L
Y
E
Y
A
G
I
P
------
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
--------------
F
M
---
T
--------
L
V
T
I
A
T
I
V
Y
--------------
W
M
N
P
A
-
G
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
--------------
I
----
Y
G
P
V
M
L
I
G
L
H
A
L
-----
E
L
A
------------------------
P
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
------------
G
Y
-
L
G
G
S
V
A
A
S
------
A
I
V
G
Y
T
V
D
--------------------------
F
-
F
G
W
D
G
G
F
M
V
M
I
G
G
S
----
I
L
A
V
I
L
L
-
I
V
V
M
I
G
E
K
R
R
-
H
-
E
Q
L
---
L
Q
E
L
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
40.51
27%
-113
- C2 -
4ZOW
1
?
A:
[56-171]
--------------------------------------------------------------------------------------------------------------
G
M
F
------
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
----
L
--------------
A
G
---
V
--------
V
W
F
I
V
T
-
C
L
--------------
A
I
L
L
A
-
Q
N
-
I
E
Q
F
T
L
L
R
F
L
Q
G
I
S
--------------
L
C
F
--
I
G
--
A
V
G
Y
A
A
I
R
-----
E
-
S
------------------------
F
E
E
A
V
C
I
K
I
T
A
-
L
M
A
N
------------
V
A
L
I
A
P
-
L
L
G
P
------
L
V
G
A
A
W
I
H
--------------------------
V
-
L
P
W
E
G
M
F
V
L
F
A
A
L
A
----
A
I
S
F
F
G
L
-
Q
R
A
M
P
E
T
A
T
R
-
I
-
G
E
K
---
L
S
L
K
E
L
G
R
D
Y
K
L
V
-------
L
K
N
G
R
F
V
----
A
G
A
L
A
L
G
F
V
S
L
--------
P
L
L
A
-------
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
---
L
---
S
S
Y
E
Y
G
L
---
L
Q
V
P
I
F
G
A
L
---
I
A
G
N
L
L
L
--
A
-
R
L
T
S
R
-
R
T
V
R
------
S
L
I
I
M
G
G
-
W
---
P
I
M
I
G
-
L
L
V
---
A
-----
A
A
A
T
V
I
S
S
H
A
-
Y
------
L
---
W
-
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
-
N
A
G
----
L
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
-
M
L
I
F
T
V
G
I
E
-
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
----
F
N
L
V
N
G
I
L
W
L
S
L
M
V
I
F
L
K
-------------------------------------------------------------------
5
PsiBlast_PDB
39.95
27%
-116
- C2 -
4ZP2
-
?
A:
[57-172]
--------------------------------------------------------------------------------------------------------------
G
M
F
------
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
----
L
--------------
A
G
---
V
--------
V
W
F
I
V
T
-
C
L
--------------
A
I
L
L
A
-
Q
N
-
I
E
Q
F
T
L
L
R
F
L
Q
G
I
S
--------------
L
C
F
--
I
G
--
A
V
G
Y
A
A
I
R
-----
E
-
S
------------------------
F
E
E
A
V
C
I
K
I
T
A
-
L
M
A
N
------------
V
A
L
I
A
P
-
L
L
G
P
------
L
V
G
A
A
W
I
H
--------------------------
V
-
L
P
W
E
G
M
F
V
L
F
A
A
L
A
----
A
I
S
F
F
G
L
-
Q
R
A
M
P
E
T
A
T
R
-
I
-
G
E
K
---
L
S
L
K
E
L
G
R
D
Y
K
L
V
-------
L
K
N
G
R
F
V
----
A
G
A
L
A
L
G
F
V
S
L
--------
P
L
L
A
-------
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
---
L
---
S
S
Y
E
Y
G
L
---
L
Q
V
P
I
F
G
A
L
---
I
A
G
N
L
L
L
--
A
-
R
L
T
S
R
-
R
T
V
R
------
S
L
I
I
M
G
G
-
W
---
P
I
M
I
G
-
L
L
V
---
A
-----
A
A
A
T
V
I
S
S
H
A
-
Y
------
L
---
W
-
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
-
N
A
G
----
L
V
R
L
T
L
F
A
S
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
-
M
L
I
F
T
V
G
I
E
-
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
----
F
N
L
V
N
G
I
L
W
L
S
L
M
V
I
F
L
K
-------------------------------------------------------------------
12
HHSearch
38.50
13%
-96
- C2 -
2GFP
-
EMRD_ECOLI
A:
[24-172]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
I
Y
I
P
A
I
A
---
D
---
M
A
--
R
D
L
---
N
V
R
E
G
A
V
Q
S
---
V
M
G
A
Y
L
L
--
T
Y
G
V
S
Q
L
-
F
Y
G
P
------
I
S
D
R
-
V
G
-
R
---
R
P
V
I
L
-
V
G
M
---
S
-----
I
F
M
L
A
T
L
V
A
V
-
T
------
T
---
S
-
S
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
I
L
V
S
P
L
-
L
A
P
L
I
G
G
L
L
D
T
M
W
-------
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
----------------------------------------------
15
HHSearch
35.55
17%
-102
- C2 -
2CFQ
-
LACY_ECOLI
A:
[263-396]
-----------------------------------------------------------------------------------------------------
Y
V
T
T
M
G
E
L
L
N
A
S
------
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
--------------
I
M
---
S
--------
V
R
I
I
G
S
-
S
F
------------------
A
-
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
--------------
V
----
P
F
L
L
V
G
C
F
K
Y
I
T
-----
S
Q
F
------------------------
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
------------
K
Q
-
L
A
M
-
I
F
M
S
------
V
L
A
G
N
M
Y
E
--------------------------
S
-
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
----
L
G
F
T
L
I
S
-
V
F
T
L
S
G
P
G
P
L
-
S
-
L
L
R
---
R
Q
V
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------