@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S12A1_HUMAN: (2015-12-08 )
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210........220.......230.......240.......250..-..-...260.......-270........280.......290......-.300.......310..----.----....320...-------....330.......340.......350........360--.....---...370...--....---380---........390.......400.......410.....----..420.......430.-..---....440.......450.......460.......470.......480.......490.-----......500.......510.......520.......530.......540...--....550.......560------........570.......580.......590...-------....600.......610.......620.--------------..------....630.......640.......650.......660.......670.......680.......690.--.--......700.....-.-.710.......720...--------.-----.-------.---.730.......-------740..-.....-750........760-.......770.......780.......790......-.800-..-.....810...--------....820--------------........830.......840....-...850.......860...----....870.......880.......890.......900.......910.....--------..920.......930.......940.......950........960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070.....-.1080......1090......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLNNSS
N
V
F
L
DSVPSNT
N
R
F
Q
V
S
V
INENHESSAAADDNTDPPHYEETSF
G
D
E
A
Q
K
R
L
R
I
S
FRPGN
Q
E
C
Y
D
N
F
L
QSGETAKTD
A
S
F
H
A
YDSHT
N
T
Y
Y
L
Q
TFGHN
T
M
DAVP
K
I
E
Y
Y
RNTGSISGPKVNR
P
S
L
L
E
I
H
E
Q
L
A
K
NVAVTPSSADRVANGDGIPGDEQAENKEDDQA
G
V
V
K
F
G
W
V
K
G
V
L
V
R
C
M
L
N
I
W
G
V
M
L
F
I
R
L
S
W
I
VGEA
G
I
G
L
-
G
V
L
I
I
L
L
S
T
M
V
T
S
I
TGLST
S
A
I
ATN
G
F
V
RGG
G
A
Y
Y
L
I
SRSLGP-EF-GGS
I
G
L
I
F
A
F
A
N
A
-
V
-
A
V
A
M
Y
V
V
G
F
A
E
T
V
V
D
L
L
KESD
S
M
M
VDPT-N
D
I
R
I
I
G
S
I
T
V
V
I
L
L
G----
I
----
S
VAGMEW
E
A
K
-------
A
Q
V
I
L
L
V
I
L
L
I
A
I
A
N
F
F
I
G
T
VIPSN-NEKKSRG
F
F
N
-
Y
--
Q
A
S
I
F
---
A
ENFGPRFT--KG
E
G
---
F
F
----
S
V
F
A
I
F
F
PA
A
T
G
ILAGANISGDLE
D
P
Q
DAIPRG
T
M
L
----
A
I
F
I
T
T
V
A
Y
L
G
V
A
I
C
V
-
G
A
---
C
V
VRDATGNMND
T
I
I
SGMNCNGSAACGLGY
D
F
S
R
C
RHEPCQYGLMN
N
F
Q
V
M
S
M
V
SG
F
G
-----
P
L
I
T
A
G
I
F
S
A
T
L
S
S
A
L
A
S
L
VS
A
P
K
V
F
Q
A
L
C
K
D
N
I
Y
K
A
L
Q
F
F
A
K
GYGKNNE
P
L
--
R
G
Y
I
L
T
F
L
I
A
M
A
F
I
L
I
-------
A
E
L
N
T
I
A
P
I
I
S
N
F
F
L
A
S
Y
A
L
I
N
F
S
C
FHASYAKSP-------GWR
P
A
Y
G
I
Y
N
M
W
V
S
L
F
G
A
V
L
C
C
A
V
M
F
V
I
--------------
N
W
------
W
A
A
V
I
T
Y
V
I
E
F
F
L
Y
V
Y
V
T
CKKPDVNWGSS
T
Q
A
L
S
Y
V
S
A
L
DNALEL
T
T
V
E
D
H
V
KNFRP
Q
C
I
V
LTGG-PM--T--R
P
A
L
L
D
I
T
H
A
F
TKN-S-
G
L
C
I
C
C
EVFV
G
P
R
K
L
C
V
--------
K
-----
E
-------
M
---
N
SG
M
A
K
K
Q
A
W
L
-------
I
K
N
K
I
-
K
A
F
Y
A
-
A
-
V
A
A
D
C
F
R
D
G
V
R
S
-
L
L
Q
ASGLGRMKPN
T
L
V
I
G
YKKNWRKA
P
L
T
E
I
E
N
Y
V
G
-
I
IHD-AF-DF
E
I
G
V
V
I
V
R
I--------SQGF
D
I
---------------
S
Q
V
L
Q
V
Q
E
E
L
E
R
L
E
Q
E
R
L
A
L
E
A
T
IK-DNECEEESG
G
I
R
G
L
F
K
KAG----K
L
N
I
T
K
TTPKKDGSINTSQSMH
V
G
E
F
N
Q
K
L
V
E
A
S
T
Q
F
K
K
KQEKG
T
I
D
V
W
W
L
F--------DDG
G
L
T
L
L
I
P
Y
I
L
T
L
R
K
KWKD
C
K
L
R
I
Y
VGGKIN-R
I
E
E
E
K
I
V
M
A
S
L
L
S
K
F
R
I
K
F
A
D
I
H
I
I
G
D
I
N
IRPN
K
E
S
W
K
V
F
E
E
M
I
E
P
Y
R
L
H
E
S
C
K
D
L
T
T
A
E
K
L
KRETPWKI
T
D
A
E
L
E
A
V
K
E
K
S
Y
R
Q
V
R
L
N
E
L
L
Q
E
H
SRAA
N
L
I
V
L
SLPVARKG
S
I
S
D
L
L
Y
M
A
W
L
E
I
L
T-KNLP
P
V
L
L
V
RGNHK
N
V
L
T
FYS
8
HHSearch
88.48
18%
-126
- C2 -
3GIA
7
Y609_METJA
A:
[3-431]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
-
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
-
N
-
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
-
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
-
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
-----
N
T
-
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
----
L
----
N
F
F
G
S
K
A
V
G
R
-------
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
----------------------
Y
V
I
P
D
L
A
P
S
A
V
S
G
---
M
I
----
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
-
I
G
---
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
-----------------------------
V
A
A
K
-
P
F
L
G
N
L
G
F
-----
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
--
F
F
E
R
K
V
-
W
F
K
S
T
---
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
---------
G
R
K
E
----
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
--------------
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
86.55
16%
-124
* C2 *
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
--
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
-
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
-
T
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
-------------
S
K
A
V
G
R
-------
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
I
P
D
L
--------------------
A
P
S
--
A
V
S
G
---
M
I
----
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-------------------------------
N
L
G
F
-----
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
E
G
--
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
---------
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
-------
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
--------------
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
78.64
15%
-121
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
V
-
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
-
T
G
G
-
I
-
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
-
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
-
I
-
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
-----
D
P
-
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
----
L
----
N
I
V
G
P
K
M
I
T
R
-------
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
----
T
Y
M
A
--------------------------
A
---
I
Q
----
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
----
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
-
M
G
---
M
I
P
N
A
A
L
R
V
S
A
S
P
F
G
------------------------------
D
A
A
R
-
M
A
L
G
D
T
A
G
-----
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
--
I
F
A
R
V
N
-
K
A
G
T
P
V
--
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
--------
K
A
R
P
---
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
--------------
G
A
------
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
76.17
12%
-110
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-501]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
S
G
F
S
L
-
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
A
A
E
M
A
T
V
---
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
-
F
A
A
I
S
F
G
Y
L
Q
I
-
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
---
N
E
-
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
----
A
----
L
T
Q
F
G
G
T
K
Y
T
-------
A
R
I
A
K
V
G
F
F
A
--------
G
I
L
L
P
A
F
-
I
L
I
A
L
A
A
I
Y
L
-------------
H
T
F
F
P
D
F
S
--
K
V
G
T
---
L
V
----
V
F
V
A
F
I
L
S
Y
M
-
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
----
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
-
A
M
---
V
I
P
G
N
E
I
N
L
S
A
-------------------------------
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
E
IEW
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
-------
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
KHPDLKR
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
LPPDNIQGDSTD
M
Y
------
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
54.92
14%
-87
- C2 -
3G40
-
?
A:
[492-759]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
R
--
E
--
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
-
K
-
G
S
V
K
L
L
G
L
A
----
D
K
E
---------------
N
-------
L
---
L
S
Q
L
P
S
I
S
E
G
F
-------
Q
E
E
G
V
-
F
S
S
W
T
-
I
-
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
R
D
R
-----
D
E
E
I
R
E
-
I
I
R
K
-
A
S
-
M
Y
R
M
G
V
L
L
F
S
K
--------
H
P
Q
A
--------------------------------------------------------------------------------------------------------
G
L
G
R
Q
N
L
I
N
L
W
I
E
N
RWDISMEL
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
-
K
M
Q
V
L
-
R
--
E
---------------------------------------------------------
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
-
L
---
D
----
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
D
S
G
E
E
N
A
L
A
L
-
7
PsiBlast_PDB
51.10
20%
-94
- C2 -
3OB6
1
ADIC_ECOLI
A:
[22-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
----
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
-
I
G
A
I
A
M
V
V
I
G
-----
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
------
L
V
L
T
I
T
C
V
V
V
L
W
----
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
-------
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
-------------
F
G
W
F
W
-
F
--
R
G
E
T
Y
---
M
A
A
W
N
---
V
--
S
G
L
G
---
T
F
G
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
----
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
-
M
G
---
M
I
P
N
A
A
L
R
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
-----
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
G
L
V
S
S
V
S
V
I
F
T
L
V
P
--
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
-------
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
-------
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
50.62
12%
-38
- C2 -
3G40
-
?
A:
[492-760]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
R
--
E
--
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
-
K
-
G
S
V
K
L
L
G
L
A
D
K
E
-------------------
N
-------
L
---
L
S
Q
L
P
S
I
S
E
G
F
-------
Q
E
E
G
V
-
F
S
S
W
T
-
I
-
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
-----
R
D
R
D
E
E
I
R
E
-
I
I
R
K
-
A
S
-
M
Y
R
M
G
V
L
L
F
S
K
HPQAGLGR
Q
N
L
I
N
L
W
I
E
NRWDISMELGNM
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
IPN
V
K
M
Q
V
L
R
E
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
L
D
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
D
S
G
--------
E
E
N
A
L
A
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.00
23%
-46
- C2 -
4DJK
-
GADC_ECOLI
A:
[57-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
C
A
A
E
M
A
T
V
D
G
W
---
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
------
F
A
-
A
I
S
-
F
-
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
----
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
-------------
T
F
F
------------------
P
D
F
S
--
K
-
V
G
---
T
L
----
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
-
P
G
---
N
E
I
N
L
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
-----
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
--
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
-------
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
-------
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
--------------
V
S
------
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.55
23%
-39
- C2 -
4DJI
-
GADC_ECOLI
A:
[57-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
C
A
A
E
M
A
T
V
D
G
W
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
------
F
A
-
A
I
S
-
F
-
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
----
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
S
G
---
A
-
I
E
M
D
S
K
T
F
F
------------------
P
D
F
S
--
K
-
V
G
---
T
L
----
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
-
P
G
---
N
E
I
N
L
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
-----
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
--
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
-------
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
-------
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
--------------
V
S
------
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
N
A
P
K
G
H
F
F
L
H
P
R
A
R
S
P
H
Y
I
V
M
N
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
43.35
13%
-75
- C2 -
1JMV
-
USPA_HAEIN
A:
[4-139]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
L
V
A
V
D
L
-
S
E
--
E
--
S
P
I
L
L
K
K
A
V
G
I
A
K
R
H
D
-
A
K
L
S
I
I
H
V
D
V
N
F
S
D
L
Y
T
--------
G
-----
L
ID
V
N
M
S
S
M
Q
--
D
R
I
S
T
E
T
Q
K
A
L
L
D
L
A
---
E
S
V
D
Y
-
P
I
S
E
K
-
L
-
S
G
S
G
D
L
G
Q
V
L
S
D
-
A
I
E
-----
Q
Y
D
V
D
L
L
V
T
G
H
H
Q
D
F
-------
W
S
K
L
M
S
-
S
T
R
Q
-
V
M
N
T
I
K
I
D
M
L
V
V
P
L
--------
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
39.73
9%
-45
- C2 -
3FG9
2
?
A:
[17-130]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
L
T
V
D
E
-
D
D
N
T
S
--
S
E
R
A
F
R
Y
A
T
T
L
A
H
D
-
Y
D
V
P
L
G
I
C
S
V
L
E
S
E
D
I
N
I
F
--------
D
SL
T
P
S
K
I
Q
A
K
R
K
H
V
---
E
D
V
V
A
E
Y
V
Q
L
A
-------
E
Q
R
G
V
N
Q
V
E
P
L
-
V
-
Y
E
G
G
D
V
D
D
V
I
L
E
Q
V
I
P
-----
E
F
K
P
D
L
L
V
T
G
A
D
T
E
F
P
H
S
K
I
A
G
A
I
G
P
R
L
-
A
R
K
A
-
P
I
-
S
V
I
V
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.17
22%
-38
- C2 -
3GIA
2
Y609_METJA
A:
[87-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
----
S
----
K
A
V
G
---
R
A
E
-------
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
---------------
A
G
L
I
T
-
I
--
H
P
S
Y
V
---
I
P
D
L
A
P
S
A
V
--
S
G
M
I
---
F
A
----
S
--
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
-
I
G
---
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
-----
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
--
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
-------
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
-------
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
--------------
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
38.42
12%
-49
- C2 -
3LOQ
1
?
A:
[22-134]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
A
M
L
L
P
T
D
L
-
S
E
--
N
--
S
F
K
V
L
E
Y
L
G
D
F
K
K
V
-
G
V
E
E
I
G
V
L
F
V
I
N
L
T
K
L
---GID
I
D
H
Y
I
D
-----
E
M
------
S
E
K
A
E
E
V
L
P
E
V
A
Q
K
I
-------
E
A
A
G
I
-
K
A
E
V
I
-
K
P
F
P
A
G
D
P
V
V
E
I
I
K
-
A
S
-------
E
N
Y
S
F
I
A
M
G
S
R
G
A
S
K
F
K
K
I
L
L
G
S
V
S
E
G
-
V
L
H
D
-
S
K
-
V
P
V
Y
I
F
K
H
D
M
V
--------
V
N
S
L
F
D
---------------
R
V
L
V
A
Y
D
F
S
K
W
A
D
R
A
L
E
Y
A
K
F
V
V
K
K
-
T
G
G
E
L
H
I
I
H
V
S
E
D
G
D
K
T
A
D
----
L
R
V
M
E
E
V
I
G
A
E
G
I
E
V
H
V
H
I
E
S
G
T
P
H
K
A
I
L
A
K
R
E
E
I
N
A
T
T
I
F
M
G
S
R
G
A
G
S
V
M
T
--------
M
I
L
G
S
T
S
E
S
V
I
R
R
S
P
V
P
V
F
V
C
K
R
G
D
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
37.77
10%
-40
- C2 -
3LOQ
-
?
A:
[171-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
L
V
A
Y
D
F
-
S
K
--
W
--
A
D
R
A
L
E
Y
A
K
F
V
V
K
K
-
T
G
G
E
L
H
I
I
H
V
S
E
D
G
D
K
T
-----------------------------
A
D
L
R
V
M
E
E
V
I
-------
G
A
E
G
I
-
E
V
H
V
H
-
I
--
E
S
G
T
P
H
K
A
I
L
A
-
K
R
E
-----
E
I
N
A
T
T
I
F
M
G
S
R
G
A
G
S
V
M
T
M
I
L
G
S
T
S
E
S
-
V
I
R
R
-
S
P
-
V
P
V
F
V
C
K
R
G
D
D
--------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
37.72
5%
-91
- C2 -
3MT0
-
?
A:
[9-129]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
V
V
I
E
P
-
D
Q
--
L
--
E
G
L
A
L
K
R
A
Q
L
I
A
G
V
-
T
Q
S
H
L
H
L
L
V
C
E
K
R
R
D
--------------------------
H
---
S
A
A
L
N
D
L
A
Q
E
L
-------
R
E
E
G
Y
-
S
V
S
T
N
-
Q
-
A
W
K
D
S
L
H
Q
T
I
I
A
-
E
Q
Q
-----
A
E
G
C
G
L
I
I
K
Q
H
F
P
D
N
P
L
K
K
-----
A
I
L
T
P
D
D
W
K
L
L
R
-
F
A
P
C
P
V
L
M
T
K
T
--------
A
R
P
W
T
G
---------------
G
K
I
L
A
A
V
D
V
G
N
N
D
G
E
H
R
S
L
H
A
G
I
I
S
-
H
A
Y
D
I
A
G
L
A
K
A
T
L
H
V
I
S
A
H
----
P
T
F
Q
L
S
E
T
I
E
A
R
Y
R
E
A
C
R
T
F
Q
A
E
Y
G
F
S
D
E
Q
L
H
I
E
E
G
P
A
D
V
L
I
P
R
T
A
Q
K
L
D
A
V
--------
V
T
V
I
G
T
V
A
R
T
G
L
S
G
A
L
I
G
N
T
A
E
V
V
L
D
T
L
E
S
D
V
L
-
V
L
K
P
D
D
I
I
A
H
L
E
E
L
A
S
K
E
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
37.51
22%
-34
- C2 -
3GI9
-
Y609_METJA
C:
[87-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
-
A
P
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
----
S
----
K
A
V
G
---
R
A
E
-------
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
---------------
A
G
L
I
T
-
I
--
H
P
S
Y
V
---
I
P
D
L
A
P
S
A
V
--
S
G
M
I
---
F
A
----
S
--
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
-
I
G
---
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
-----
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
--
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
-------
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
-------
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
--------------
K
S
------
L
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
37.28
22%
-38
- C2 -
3GI8
-
Y609_METJA
C:
[87-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
Y
V
-
I
-
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
N
I
A
I
-
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
----
S
----
K
A
V
G
---
R
A
E
-------
F
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
---------------
A
G
L
I
T
-
I
--
H
P
S
Y
V
---
I
P
D
L
A
P
S
A
V
--
S
G
M
I
---
F
A
----
S
--
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
-
I
G
---
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
-----
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
--
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
-------
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
-------
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
--------------
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
37.25
11%
-53
- C2 -
3DLO
1
?
A:
[26-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
V
A
V
D
K
K
S
D
--
R
--
A
E
R
V
L
R
F
A
A
E
E
A
R
L
-
R
G
V
P
V
Y
V
V
H
S
L
P
G
G
G
R
T
K
D
--------
E
D
I
I
--
E
-------
A
---
K
E
T
L
S
W
A
V
S
I
I
-------
R
K
E
G
A
-
E
G
E
E
H
L
L
-
V
R
G
K
E
P
P
D
D
I
V
D
-
F
A
D
-----
E
V
D
A
I
A
I
V
I
G
I
R
K
R
S
P
T
G
K
L
I
F
G
S
V
A
R
D
-
V
I
L
K
-
A
N
-
K
P
V
I
C
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
36.64
7%
-27
- C2 -
3FDX
3
?
A:
[3-117]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
L
V
P
I
D
I
-
S
D
--
K
EF
T
E
R
I
I
S
H
V
E
S
E
A
R
I
-
D
D
A
E
V
H
F
L
T
V
I
P
S
--------------------
G
-------
M
---
D
E
L
R
E
G
S
E
T
Q
L
K
E
I
A
K
K
F
S
I
P
E
D
-
R
M
H
F
H
-
V
-
A
E
-
G
S
P
K
D
K
I
L
A
-
L
A
K
-----
S
L
P
A
D
L
V
I
I
A
S
H
R
P
D
I
T
T
Y
L
L
G
S
N
A
A
A
V
-
V
R
H
A
-
E
C
-
S
V
L
V
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
36.25
12%
-51
- C2 -
3DH4
1
?
A:
[51-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
K
S
L
P
W
W
A
V
G
A
S
L
-
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
-
A
S
-
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
--
K
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
-
K
L
-
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
-
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-
P
------
L
-
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
----
S
----
I
------
V
V
W
-------
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
DA
A
P
G
H
F
EMI
L
D
Q
S
N
P
Q
Y
M
--
N
L
P
G
IAV
L
I
G---
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
----
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
-
I
A
AYV
I
T
S
D
P
Q
L
M
A
S
L
G
D
I
A
A
--------
T
N
L
P
S
--
A
-
A
N
--
A
D
K
A
Y
----
P
W
L
T
Q
F
L
P
V
G
V
K
-----
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
--
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
-------
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
-------
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
--------------
F
M
------
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
-
Y
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------