@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S12A2_HUMAN: (2015-12-09 )
MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS
Atome Classification :
(20 SA)
.........10........20........30........40...-.....50........60........70.........80........90........100.......110.......--120.......130.......140.......150.......160....-...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340......--..350.......360-..-.....370...---.-...380.......390.......400----.......410.......420..-.....430.-......440.......450......-.460-.....-..-470......----.480--.....---.---.490--.......500.......510.......520..----.....530.......540...--....-550-.......560.......570.......580.......590......-----.600.......610.......620.......630.......640.......650--.......660......-------.670.......680.......690.......700-------.......710.......720.......730------------..------.......740.......750.......760.......770.......780.......790.....-..--800-------.......810..-.-.-...820.......830.---------.-------.....840....----...850.....-.-..860.......-870.......880.......890.......900...-.-...-910........920---------------........930.......940......---.950.......960.......970...---....980.......990.......1000......1010......1020......1030-----.........1040......1050......1060-......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190.......1200......1210
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPRPTAPSSGAPGLAGVGETP
S
A
A
A
L
A
A
A
R
VELPGTAVPSVPE-DAAPASRDGGGVRDEGPAAAGDGLGR-PLGPTPSQS
R
F
Q
V
D
L
VSENAG
R
A
A
A
A
A
A
A
A
A
A
A
A
AAAGAGAGAKQTPAD--GEASGESEPAKGSEEAK
G
R
F
R
V
N
F
VDPAASSSAEDSLSDAAGVGVDG-PNVSFQNGGD
T
V
LSEGSSLHSGGGGGSGH
H
Q
H
Y
Y
Y
DTHT
N
T
Y
Y
L
R
TFGH
N
T
M
DAVPR
I
D
H
Y
R
H
T
A
A
Q
L
G
E
K
L
L
R
P
S
L
A
E
L
H
D
E
L
E
KEPFEDGFANGEESTPTR
D
A
V
V
T
Y
TAESK
G
V
V
K
F
G
W
I
K
G
V
L
V
R
C
M
L
N
I
W
G
V
M
L
F
I
R
L
S
W
I
VGQAG
I
G
L
S
V
L
V
I
M
M
A
T
V
V
T
T
I
TGLST
S
A
I
-ATN
G
F
V
--RGG
G
A
Y
Y
L
I
SRSLGP-EF-G
G
A
I
G
L
I
F
A
F
A
---
N
-
A
V
A
V
A
M
Y
V
V
G
F
A
E
T
V
V
E
L
L
K
EH
S
I
L
M
----
I
DEIN
D
I
R
I
I
G
A
I
T
V
V
I
L
LGIS-VAGMEWE
A
K
-
A
Q
I
V
L
L
V
I
L
L
L
A
I
G
D
F
V
I
G
T
F
IPLE-SKKP-KGFFG-
Y
K
-
S
E
I
FNENFG----PDFR--
E
E
E
T
F
---
F
---
S
V
F
A
--
I
F
F
PA
A
T
G
ILAGANISGDLADPQSAIPK
G
T
L
L
----
A
I
L
I
T
T
L
V
Y
V
G
I
A
V
S
V
G
S
C
V
V
--RDAT-GNV-N
D
T
I
V
T
E
L
TNCTS
A
A
C
K
L
N
F
DFSSCESSPCSYGLMN
N
F
Q
V
M
S
M
VSG-----
F
T
P
L
I
S
A
G
I
F
S
A
T
L
S
S
A
L
A
S
L
VS
A
P
K
I
F
Q
A
L
C
KDNI
Y
P
A
F
Q
M
F
A
K
GYGKNNE
P
L
--
R
G
Y
I
L
T
F
L
I
A
L
G
F
I
L
I
-------
A
E
L
N
V
I
A
P
I
I
S
N
F
F
L
A
S
Y
A
L
I
N
F
S
V
F
H
A
S
L
AKSP-------GW
R
P
A
F
K
Y
Y
N
M
W
I
S
L
L
G
A
I
L
C
C
I
V
M
F
V
I
--------------
N
W
------
W
A
A
L
L
T
Y
V
I
V
L
G
L
Y
I
Y
V
T
Y
KKPDVNWGSS
T
Q
A
L
T
Y
L
N
A
L
Q
H
S
I
RLS
G
V
E
D
H
V
K
NFRP
Q
C
L
V
M
TGA-PN--S
R
P
-------
A
L
L
H
L
V
H
D
F
TKN-V-
G
-
L
M
I
CGHVHM
G
P
R
R
Q
A
M
K
---------E-------MSI
D
Q
A
K
Y
Q
R
W
L
----
I
K
N
K
M
-
K
A
F
YA-P-V
H
A
D
D
L
R
E
G
A
Q
Y
-
L
M
Q
A
AGLGRMKPN
T
L
V
L
GF
K
K
D
W
L
Q
A
D
M
R
D
V
D
M
Y
I
N
-
L
-
F
H
D
-
A
F-
D
I
Q
Y
G
V
V
V
I
R
----------------LKEGLD
I
S
H
LQ
G
Q
E
E
L
L
S
S
QEKSPGT
K
---
D
V
V
V
S
V
E
YSKKSDLDTSKPLSEKPITH---KVEEEDGK
T
A
T
Q
P
L
L
KKESKG
P
I
V
P
LNV
A
D
Q
K
L
L
E
A
S
T
Q
F
Q
K
KQGKN
T
I
D
V
W
W
L
F--------DDG
G
L
T
L
L
I
P
Y
L
LTTKKKWKD
C
K
I
R
V
F
IGGKIN-RI
D
H
D
R
R
A
M
A
T
L
L
S
K
FRI
D
F
S
D
I
M
V
L
GDINTKPKKEN
I
I
A
F
E
E
I
I
E
P
Y
RLHEDD
K
E
Q
D
I
A
D
K
MKEDEP
W
R
ITDNE
L
E
L
Y
K
TK
T
Y
R
Q
I
R
L
N
E
L
L
K
E
HSSTA
N
I
I
V
M
SLPVARKG
A
V
S
S
A
L
Y
M
A
W
L
E
A
L
S-KDLP
P
I
L
L
V
RGNH
Q
S
V
L
T
FYS
14
HHSearch
90.12
18%
-130
- C2 -
3GIA
7
Y609_METJA
A:
[3-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
-
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
-
G
A
K
-
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
-
N
I
I
T
G
A
L
S
I
L
L
W
M
S
---
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
---------
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
-
F
F
G
S
K
A
V
G
R
-
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
------------------
S
Y
V
I
----
P
D
L
A
P
S
A
V
S
G
M
---
I
---
F
A
S
A
--
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
--
I
D
E
L
-
I
K
A
-
S
E
N
A
L
A
-----------------------------
V
A
A
K
-
P
F
L
G
N
L
-----
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
--
F
F
E
R
K
V
-
W
F
K
S
T
---
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
---------
G
R
K
E
----
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
--------------
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
84.95
15%
-129
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
-
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
-
G
A
K
-
I
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
-
T
G
A
L
S
I
L
L
W
M
S
---
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
----
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
------
S
K
A
V
G
R
-
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
-
I
P
D
L
------------------
A
P
S
A
--
V
S
G
M
I
---
F
---
A
S
A
I
--
F
F
L
-
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
--
I
D
E
L
-
I
K
A
-
S
E
N
A
L
A
V
A
A
K
P
F
L
G
------------------------------
N
L
-----
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
E
G
--
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
---------
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
-------
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
--------------
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
80.57
15%
-118
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-501]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
A
A
E
M
-
A
T
V
-----
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
A
I
S
F
G
Y
L
Q
---
I
-
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
--------
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
-
T
Q
F
G
G
T
K
Y
T
-
A
R
I
A
K
V
G
F
F
A
--------
G
I
-------
L
L
P
-
A
F
I
L
I
-
A
L
-
A
A
I
Y
L
H
T
F
F
----
P
D
F
S
--
K
V
G
T
L
---
V
---
V
F
V
A
--
F
I
L
S
Y
M
-
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
----
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
P
--
G
N
E
I
-
N
L
S
-
A
-------------------------------
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
PEIEW
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
-------
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
KHPDLKR
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
LPPDNIQGDSTD
M
Y
------
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
79.63
15%
-131
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-431]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
-
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
-
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
-
S
F
L
-
D
P
--
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
---
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
---------
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
-
I
V
G
P
K
M
I
T
R
-
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
----
E
T
----
Y
M
--
A
--------------------
A
I
---
Q
---
S
T
L
N
--
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
----
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
--
N
A
A
L
-
R
V
S
-
A
S
P
F
G
------------------------------
D
A
A
R
M
-
A
L
G
D
T
-----
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
--
I
F
A
R
V
N
-
K
A
G
T
P
V
--
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
-------
K
A
R
P
----
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
--------------
G
A
K
E
V
---
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
52.09
13%
-80
- C2 -
3G40
-
?
A:
[492-759]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
R
--
E
L
M
-------
G
T
F
D
F
L
R
D
I
T
Y
P
-
K
-
G
-
S
V
K
L
L
G
L
A
----
D
K
E
-----------
N
-------
L
L
S
Q
L
P
S
I
S
E
G
F
----
Q
E
E
G
V
-
F
S
S
W
T
-
I
-
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
R
D
R
-----
D
E
E
I
R
E
-
I
-
I
R
K
-
A
S
-
M
Y
R
M
G
V
L
L
F
S
----------------
K
H
P
Q
A
------------------------------------------------------------------------------------------------
G
L
G
R
Q
N
L
I
N
L
W
I
E
N
RWDISMEL
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
-
K
M
Q
V
L
-
R
--
E
---------------------------------------------------------
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
-
L
---
D
----
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
D
S
G
E
E
N
A
L
A
L
-
8
PsiBlast_PDB
49.99
21%
-83
- C2 -
3OB6
1
ADIC_ECOLI
A:
[22-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
G
G
I
A
I
------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
DP
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
-
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
-
A
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
L
T
----
I
T
C
V
--------
V
V
L
W
I
F
V
L
L
N
-
I
V
G
P
K
M
I
T
R
-
V
Q
A
V
A
T
V
L
A
L
-----------
I
P
I
V
-
G
I
A
V
-
F
G
W
F
W
-
F
R
-
G
E
T
Y
M
A
A
W
------
N
V
S
--
G
L
G
T
F
---
G
A
I
Q
S
T
L
N
--
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
----
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
I
P
--
N
A
A
L
-
R
V
S
-
A
S
P
F
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
-----
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
G
L
V
S
S
V
S
V
I
F
T
L
V
P
--
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
-------
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
-------
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.41
22%
-91
- C2 -
4DJI
-
GADC_ECOLI
A:
[38-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
A
A
E
M
-
A
T
V
D
G
W
--
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
-------
A
---
I
-
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
KWPA
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
-
S
G
----
A
I
-------
E
M
D
S
K
T
F
F
----
P
D
F
S
--
K
V
G
T
L
---
V
----
V
F
V
--
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
P
G
N
E
I
--
N
L
S
A
-
G
V
M
-
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
-----
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
--
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
-------
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
-------
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
--------------
V
S
------
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
N
A
P
K
G
H
F
F
L
H
P
R
A
R
S
P
H
Y
I
V
M
N
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
46.44
11%
-8
- C2 -
3G40
-
?
A:
[492-760]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
R
--
E
L
M
-------
G
T
F
D
F
L
R
D
I
T
Y
P
-
K
-
G
-
S
V
K
L
L
G
L
A
D
K
E
---------------
N
-------
L
L
S
Q
L
P
S
I
S
E
G
F
----
Q
E
E
G
V
-
F
S
S
W
T
-
I
-
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
-----
R
D
R
D
E
E
I
R
E
-
I
-
I
R
K
-
A
S
-
M
Y
R
M
G
V
L
L
F
S
K
HPQAGLGRQN
L
I
N
L
W
I
E
N
R
W
D
I
S
M
E
L
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
RI
P
N
V
K
M
Q
V
L
R
E
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
L
D
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
D
S
G
--------
E
E
N
A
L
A
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
45.77
22%
-92
- C2 -
4DJK
-
GADC_ECOLI
A:
[38-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
A
A
E
M
-
A
T
V
D
G
W
-----
G
V
F
A
W
V
S
N
T
L
G
P
-
R
W
-
G
F
A
-------
A
---
I
-
S
F
G
Y
L
Q
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
KWPA
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
Y
L
H
---------------------
T
F
F
----
P
D
F
S
--
K
V
G
T
L
---
V
----
V
F
V
--
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
I
P
G
N
E
I
--
N
L
S
A
-
G
V
M
-
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
-----
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
--
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
-------
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
-------
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
--------------
V
S
------
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.11
22%
-43
- C2 -
3GIA
2
Y609_METJA
A:
[87-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
---
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
----
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
-
A
V
G
-----
R
-
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
-
I
---------------------
P
D
L
A
--
P
S
A
V
S
---
G
---
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
----------
A
I
-
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
-----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
--
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
-------
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
-------
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
--------------
F
S
------
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
41.14
22%
-38
- C2 -
3GI8
-
Y609_METJA
C:
[87-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
---
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
----
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
-
A
V
G
-----
R
-
A
E
F
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
-
I
---------------------
P
D
L
A
--
P
S
A
V
S
---
G
---
M
I
F
A
SA
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
----------
A
I
-
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
-----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
--
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
-------
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
-------
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
--------------
F
S
------
N
N
M
Y
V
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
40.51
16%
-57
- C2 -
1JMV
-
USPA_HAEIN
A:
[4-139]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
L
V
A
V
D
L
-
S
E
--
E
S
P
-------
I
L
L
K
K
A
V
G
I
A
K
R
H
D
-
A
-
K
L
S
I
I
H
V
D
V
N
F
S
D
L
Y
T
G
LID
V
N
M
S
S
-
M
-------
Q
D
R
I
S
T
E
T
Q
K
A
L
L
D
L
A
E
S
V
D
Y
-
P
I
S
E
K
-
L
-
S
G
S
G
D
L
G
Q
V
L
S
D
-
A
I
E
-----
Q
Y
D
V
D
L
L
V
T
G
H
H
Q
D
F
W
-------
S
K
L
M
S
-
S
-
T
R
Q
-
V
M
N
T
I
K
I
D
M
L
V
V
P
----------------
L
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.17
22%
-36
- C2 -
3GI9
-
Y609_METJA
C:
[87-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
S
I
L
L
W
M
S
---
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
-
A
P
I
N
T
F
----
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
-
A
V
G
-----
R
-
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
-
I
---------------------
P
D
L
A
--
P
S
A
V
S
---
G
---
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
----
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
----------
A
I
-
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
-----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
M
E
G
V
A
S
I
T
S
--
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
-------
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
-------
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
--------------
F
S
------
N
N
M
Y
V
K
S
L
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
37.93
9%
-57
- C2 -
3MT0
-
?
A:
[135-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
L
A
A
V
D
V
-
G
N
--
N
D
G
E
H
R
S
L
H
A
G
I
I
S
H
A
Y
D
I
A
G
L
-
A
K
A
-
T
L
H
V
I
S
A
H
P
--------T
F
Q
L
S
E
---
T
I
------
E
A
R
Y
R
E
A
C
R
T
F
Q
----
A
E
Y
G
F
-
S
D
E
Q
L
-
H
-
I
E
E
G
P
A
D
V
L
I
P
R
-
T
A
Q
-----
K
L
D
A
V
V
T
V
I
G
T
V
A
R
T
G
L
S
G
A
-----
L
I
G
N
T
-
A
E
V
V
L
D
-
T
L
E
S
D
V
L
V
L
K
----------------
P
D
D
I
I
A
H
L
E
E
L
A
S
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
37.47
12%
-64
- C2 -
3DH4
1
?
A:
[51-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
K
S
L
P
W
W
A
V
G
A
S
-
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
-
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
-
F
I
E
--
K
--
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
-
K
L
-
K
T
I
L
A
V
F
W
I
S
L
---
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-
P
----------
L
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
-------
V
V
W
-
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
DQSN
P
Q
Y
M
--
N
L
P
G
I
AVL
I
G--
G
L
W
V
--
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
----
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
IT
S
D
P
Q
L
M
A
S
-
L
G
D
I
A
A
--------
T
N
L
P
S
A
---
A
N
--
A
D
K
A
Y
P
---
W
L
-
T
Q
F
L
P
V
G
-----
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
--
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
-------
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
-------
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
--------------
F
M
------
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
-
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
37.32
26%
91
- C2 -
3TI7
-
?
A:
[48-196]
-------------------------------
V
D
L
N
G
N
M
L
P
G
Y
D
F
I
S
S
A
P
N
A
R
D
G
D
Q
-
R
D
N
N
P
A
D
E
G
D
W
F
D
N
W
D
C
G
G
Y
P
D
P
R
R
E
K
K
F
S
T
W
H
G
S
H
V
A
G
T
I
A
A
V
T
N
N
G
V
G
V
A
G
V
A
Y
G
A
K
V
I
P
V
R
VL
G
K
C
G
G
-----------------------
Y
D
S
D
I
T
D
G
M
Y
W
S
A
G
G
H
I
D
G
V
P
D
N
--
Q
N
P
A
Q
V
V
-----
N
M
S
L
G
G
G
G
G
C
S
Q
N
S
Q
R
M
I
D
K
T
T
N
L
G
A
L
I
V
I
A
A
G
N
E
N
Q
D
A
S
R
T
W
P
S
S
C
N
N
V
L
S
V
G
A
T
T
P
K
G
K
R
A
P
F
S
N
Y
G
A
R
V
H
L
A
A
P
G
T
N
I
L
S
T
I
D
V
G
Q
A
G
P
V
R
S
S
Y
G
M
K
A
G
T
S
M
A
A
P
H
V
S
G
V
A
A
L
V
I
S
A
A
N
S
I
G
K
T
L
T
P
S
E
L
S
D
I
L
V
R
T
T
S
R
F
N
G
R
L
D
R
G
L
G
S
G
I
V
D
-
A
N
A
A
V
N
--
A
V
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
36.87
11%
-2
- C2 -
3FG9
2
?
A:
[17-130]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
L
T
V
D
E
-
D
D
N
T
S
S
E
-------
R
A
F
R
Y
A
T
T
L
A
H
D
-
Y
D
V
-
P
L
G
I
C
S
V
L
E
S
E
D
I
N
I
F
D
SL
T
P
S
----
K
I
Q
A
K
R
K
H
V
E
D
V
V
A
E
Y
V
Q
L
A
----
E
Q
R
G
V
N
Q
V
E
P
L
-
V
-
Y
E
G
G
D
V
D
D
V
I
L
E
Q
V
I
P
-----
E
F
K
P
D
L
L
V
T
G
A
D
T
E
F
P
H
S
K
I
A
G
A
I
G
P
R
L
-
A
-
R
K
A
-
P
I
-
S
V
I
V
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
36.61
14%
-29
- C2 -
3LOQ
1
?
A:
[23-134]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
L
L
P
T
D
L
-
S
E
--
N
S
F
-------
K
V
L
E
Y
L
G
D
F
K
K
V
-
G
V
E
-
E
I
G
V
L
F
V
I
N
L
T
K
L
----GID
I
D
H
Y
I
D
E
M
S
E
K
---
A
E
E
V
L
P
E
V
A
Q
K
I
----
E
A
A
G
I
-
K
A
E
V
I
-
K
P
F
P
A
G
D
P
V
V
E
I
I
K
-
A
S
-------
E
N
Y
S
F
I
A
M
G
S
R
G
A
S
K
F
K
K
I
L
L
G
S
V
S
E
G
-
V
-
L
H
D
-
S
K
-
V
P
V
Y
I
F
K
H
D
M
----------------
V
V
N
S
L
F
D
R
V
L
V
A
Y
D
F
S
K
W
A
D
R
A
L
E
Y
A
K
---
F
V
V
K
K
T
G
G
E
L
H
I
I
H
V
S
E
D
G
D
K
T
A
D
L
R
V
---
M
E
E
V
I
G
A
E
G
I
E
V
H
V
H
I
E
S
G
T
P
H
K
A
I
L
A
K
R
E
E
I
N
A
T
T
I
F
M
G
S
R
G
A
G
S
V
M
T
M
I
L
G
S
T
--------
S
E
S
V
I
R
R
S
P
V
P
V
F
V
C
K
R
G
D
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
36.37
8%
-59
- C2 -
3MT0
-
?
A:
[9-129]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
V
V
I
E
P
-
D
Q
--
L
E
G
-------
L
A
L
K
R
A
Q
L
I
A
G
V
-
T
-
Q
S
H
L
H
L
L
V
C
E
K
R
R
D
----------------------
H
S
A
A
L
N
D
L
A
Q
E
L
----
R
E
E
G
Y
-
S
V
S
T
N
-
Q
-
A
W
K
D
S
L
H
Q
T
I
I
A
-
E
Q
Q
-----
A
E
G
C
G
L
I
I
K
Q
H
F
P
D
N
P
L
K
K
-----
A
I
L
T
-
P
D
D
W
K
L
L
R
-
F
A
P
C
P
V
L
M
T
K
----------------
T
A
R
P
W
T
G
G
K
I
L
A
A
V
D
V
G
N
N
D
G
E
H
R
S
L
H
---
A
G
I
I
S
H
A
Y
D
I
A
G
L
A
K
A
T
L
H
V
I
S
A
H
P
T
F
---
Q
L
S
E
T
I
E
A
R
Y
R
E
A
C
R
T
F
Q
A
E
Y
G
F
S
D
E
Q
L
H
I
E
E
G
P
A
D
V
L
I
P
R
T
A
Q
K
L
D
A
V
V
T
V
I
G
T
--------
V
A
R
T
G
L
S
G
A
L
I
G
N
T
A
E
V
V
L
D
T
L
E
S
D
V
L
V
L
K
P
D
D
-
I
I
A
H
L
E
E
L
A
S
K
E
------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
36.22
11%
-13
- C2 -
3DLO
1
?
A:
[26-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
V
A
V
D
K
K
S
D
--
R
A
E
-------
R
V
L
R
F
A
A
E
E
A
R
L
-
R
G
V
-
P
V
Y
V
V
H
S
L
P
G
G
G
R
T
K
D
E
D
I
I
------
E
-------
A
K
E
T
L
S
W
A
V
S
I
I
----
R
K
E
G
A
-
E
G
E
E
H
L
L
-
V
R
G
K
E
P
P
D
D
I
V
D
-
F
A
D
-----
E
V
D
A
I
A
I
V
I
G
I
R
K
R
S
P
T
G
K
L
I
F
G
S
V
A
R
D
-
V
-
I
L
K
-
A
N
-
K
P
V
I
C
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------