@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S12A4_HUMAN: (2015-12-09 )
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....-..200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300..--------.....310.......320.......330.......340..----.....350.......360.......370.......380.......390.......400.......410.......----420.......430.......440.......450.......460.......470-........480.......490.....-..500.......510.......520.......530.......540.......550.......560.......570------........580.......590.......600.......610.......620.......630.---..------....640.......650.......660.......670.......680.......690.......700......-..710.......720.-......730.....--.-.--740........750-.---........760.-......770.......780.......790.......800.......810.......820.......830.......840.......--------850--------.......860.......870.......880.......890.......900.......910.......920.......930.........940.......950..--.....960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
H
F
T
V
V
PVDGPRRGDYDNLEG
L
S
WVDYGERAELDDSDGHGNHRESSPFLS
P
L
E
ASRGID
Y
Y
DR
N
L
A
L
F
E
E
ELDIR
P
K
V
S
S
L
L
G
K
L
V
S
Y
T
N
LTQG
A
K
E
H
EEAESGEGTRRRAAEAPS
M
G
T
L
M
G
V
Y
L
P
C
L
Q
N
I
F
G
V
I
L
F
L
R
L
T
W
MVG
T
A
G
V
L
Q
A
L
L
I
V
L
I
C
C
C
C
T
L
L
T
A
I
S
M
S
A
IATNGVVPAGG
S
Y
F
M
I
SRSLGPEF-G
G
A
V
G
L
C
F
Y
L
G
T
T
F
A
A
A
M
Y
I
L
G
A
I
E
I
L
L
T
YIAP
P
A
A
I
FYPSGAHDTSNATLNN
M
R
V
Y
G
T
I
F
L
T
F
M
T
L
V
V
F
V
G
V
K
Y
V
N
K
F
A
S
L
F
L
A
C
V
I
I
S
I
L
S
I
Y
AG
G
I
K
S
IFDPPV--------F
P
V
C
MLGNRTLS
R
D
Q
F
D
I
C
A
K
T
AVVDN
E
T
V
A
T
Q
L
W
S
F
F
CH----SPNLTTDSCD
P
Y
F
M
LNNVTEIPGIP
G
A
A
A
G
V
L
Q
E
N
L
W
S
A
Y
LEKGD
I
V
E
KHGLPSADA
P
S
L
K
ESL
P
L
Y
V
V
A
D
I
A
T
S
----
F
T
V
L
V
G
I
F
FPS
V
T
G
IMAGSNRSG
D
L
R
D
A
Q
KSIP
V
G
T
I
L
A
I
I
T
T
S
L
V
Y
F
S
S
V
V
--
L
F
G
A
C
IE
G
V
V
L
RDKYGDGVSR
N
L
V
V
G
-TLAWPS
P
W
V
I
V
I
G
S
F
F
S
T
C
G
A
G
L
Q
SLTG
A
P
R
L
L
Q
A
I
A
KDN
I
I
P
F
L
R
V
FGHGKVNGE
P
T
W
A
L
L
L
T
A
L
I
A
E
L
G
I
L
I
-------
A
S
L
D
M
V
A
P
I
L
S
M
F
F
L
M
C
Y
L
F
V
N
L
A
C
A
V
Q
T
L
L
RTPNWRPR
F
K
Y
Y
H
W
A
L
S
F
L
G
M
S
L
C
L
A
L
M
F
V
S
---
S
W
------
Y
Y
A
L
V
A
M
L
I
A
G
M
I
Y
K
Y
I
EYQGAE
K
E
WGDGIRGL
S
L
S
A
A
R
Y
A
L
L
R
LEEGPPHTKNWR
P
Q
L
L
V
L
L
KL-DEDLHVK-
Y
P
R
L
L
T
F
A
S
Q
LKAGK
G
-
L
T
I
V
G
S
V
I
Q
G
S
F
L
E
--
S
-Y--G
E
-
A
Q
A
A
E
Q
T
I
K
---
N
---
M
M
E
I
E
K
V
K
G
F
C
Q
-
V
V
V
A
S
K
V
R
E
G
L
A
H
L
I
Q
S
CGLGGMRHN
S
V
V
L
GWPYGWRQSED
P
R
A
W
K
T
F
I
D
T
V
R
C
T
T
A
A
H
L
A
L
L
VPK
N
I
AFYPS
N
H
E
R
Y
L
EGHI
D
V
W
--------
W
I
V--------HDG
G
M
L
M
L
L
P
F
L
L
R
Q
H
K
V
W
R
K
C
R
M
R
I
F
T
V
A
QMDDN
S
I
Q
M
K
K
D
L
A
V
F
L
Y
H
L
R
L
E
A
E
V
E
V
V
E
MHNSDI
S
A
Y
T
Y
E
R
T
L
M
M
E
--
Q
R
S
Q
M
L
R
Q
M
RLT
K
T
E
R
E
R
E
A
Q
L
V
K
--
D
R
H
S
A
L
R
L
E
S
L
YSDEEDESAVGA
D
K
I
Q
M
T
WTRDKYMTETWDPSHAP
D
N
F
R
E
L
V
H
IKPD
Q
S
N
V
R
R
M
H
T
A
V
K
L
N
E
V
I
V
TRSHD
A
R
L
V
L
L
NMPGPPRNSEG
D
E
N
Y
M
E
F
L
E
V
L
T
E
G
L
E
R
V
L
L
V
RGGG
R
E
V
I
T
IYS
15
HHSearch
92.51
19%
-142
- C1 -
3GIA
7
Y609_METJA
A:
[3-431]
----------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
-
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
-
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
--------------
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
-
H
P
S
---------------------------------------------------------------------------------------
Y
V
I
P
D
L
A
P
----------------------------
S
A
V
S
G
----
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
--
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
--
A
L
A
V
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
--
V
G
G
R
K
E
I
----
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
---
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
89.15
16%
-147
- C1 -
3L1L
2
ADIC_ECO57
A:
[7-431]
------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
-
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
-
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
-
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
--------------
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
-
F
R
G
E
T
--------
Y
----------------------------------------------------
M
A
---------------------------------------------------------------
A
----
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
--
A
I
M
G
M
I
P
N
A
A
L
R
V
S
-
A
S
P
F
--
G
D
A
A
R
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
--
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
-
G
H
F
G
K
A
R
P
---
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
---
G
A
K
E
V
---
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
79.83
16%
-93
- C1 -
3GIA
7
Y609_METJA
A:
[3-435]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
VSNA
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
NA
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
--------
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
--
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
-
L
G
N
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
--------
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
---
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.52
26%
-37
- C1 -
3GIA
4
Y609_METJA
A:
[175-361]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.09
26%
-33
- C1 -
3GI9
-
Y609_METJA
C:
[175-361]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.56
26%
-34
- C1 -
3GI8
-
Y609_METJA
C:
[175-361]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Y
V
I
P
D
L
A
P
S
AVSG
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
SA
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
48.34
14%
-47
- C1 -
3G40
-
?
A:
[492-760]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
-----
E
D
P
R
E
-
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
K
G
-
S
V
K
L
L
G
L
A
D
K
-----------
E
N
-
L
L
S
Q
L
P
S
I
S
---
E
---
G
F
Q
E
E
G
V
F
S
S
W
T
-
I
I
-----
E
E
N
L
V
V
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
------
E
N
R
D
R
D
E
E
I
R
E
I
I
R
K
A
S
M
Y
R
M
G
V
L
L
F
S
K
----
H
P
Q
A
G
L
G
R
Q
N
L
I
N
L
W
I
E
NRWDIS
M
E
L
--------
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
K
M
Q
V
L
R
E
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
L
D
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
--
D
S
G
E
E
N
A
L
A
L
L
------------------------------------------------------------------------------------------------------------------------
24
HHSearch
46.11
15%
-18
- C1 -
3DLO
1
?
A:
[26-128]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
V
A
V
D
K
K
S
D
----
R
-
A
E
R
V
L
R
F
A
A
E
E
A
R
L
R
G
V
P
V
Y
V
V
H
S
L
P
G
G
G
R
T
K
D
E
D
I
--
I
E
-
A
K
E
T
L
S
W
A
V
---
S
---
I
I
R
K
E
G
A
E
G
E
E
H
L
L
V
R
G
K
E
P
P
D
D
I
V
D
F
A
D
E
-----
V
D
A
I
A
I
V
I
G
I
R
K
R
S
P
T
G
K
L
I
F
G
S
V
A
R
D
V
I
L
K
A
N
K
P
V
I
C
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
44.45
13%
-27
- C1 -
3FDX
3
?
A:
[3-117]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
L
V
P
I
D
I
-
S
D
---
K
E
F
T
E
R
I
I
S
H
V
E
S
E
A
R
I
D
D
A
E
V
H
F
L
T
V
I
P
S
---------G
M
D
E
L
R
E
G
S
E
T
Q
L
K
---
E
I
A
K
K
F
S
I
P
E
D
R
M
H
F
H
-
V
A
E
-
G
S
P
K
D
K
I
L
A
L
A
K
S
-----
L
P
A
D
L
V
I
I
A
S
H
R
P
D
I
T
T
Y
L
L
G
S
N
A
A
A
V
V
R
H
A
E
C
S
V
L
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
43.81
13%
-60
- C1 -
3G40
-
?
A:
[492-701]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
----
R
E
-
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
K
G
-
S
V
K
L
L
G
L
A
----
D
K
--
E
-----
N
-
L
L
S
Q
L
P
S
I
S
---
E
---
G
F
Q
E
E
G
V
F
S
S
W
T
-
I
I
-----
E
E
N
L
V
V
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
R
D
R
D
------
E
E
I
R
E
I
I
R
K
A
S
M
Y
R
M
G
V
L
L
F
S
K
H
P
Q
A
----
G
L
G
R
Q
N
L
I
N
L
W
--------
I
E
N
RWDISMEL
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
42.39
10%
-36
- C1 -
3MT0
-
?
A:
[9-101]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
V
V
I
E
P
-
D
----
Q
L
-
E
G
L
A
L
K
R
A
Q
L
I
A
G
V
T
Q
S
H
L
H
L
L
V
C
E
K
R
R
D
------------
H
S
A
A
L
N
D
L
A
---
Q
---
E
L
R
E
E
G
Y
S
V
S
T
N
-
Q
A
W
K
D
S
L
H
Q
T
I
I
A
E
Q
Q
A
-----
E
G
C
G
L
I
I
K
Q
H
F
P
D
N
P
L
K
K
A
I
L
T
P
D
D
W
K
L
L
R
F
A
P
C
P
V
L
M
T
K
T
A
R
P
W
T
G
G
K
I
L
A
A
V
D
V
G
N
N
D
G
E
H
R
--------
S
L
H
--------
A
G
I
I
S
H
A
Y
D
I
A
G
L
A
K
A
T
L
H
V
I
S
A
H
P
T
F
Q
L
S
E
T
I
E
A
R
Y
R
E
A
C
R
T
F
Q
A
E
Y
G
F
S
D
E
Q
L
H
I
E
E
G
P
A
D
V
L
I
P
R
T
A
Q
K
L
D
A
V
V
T
--
V
I
G
T
V
A
R
T
G
L
S
G
A
L
I
G
N
T
A
E
V
V
L
D
--
T
L
E
S
D
V
L
V
L
K
P
D
D
I
I
A
H
L
E
E
L
A
S
K
E
----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
39.25
30%
203
- C1 -
1BD0
1
ALR_GEOSE
A:
[136-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
5
PsiBlast_PDB
39.14
30%
195
- C1 -
1SFT
1
ALR_GEOSE
A:
[136-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
21
HHSearch
36.97
11%
36
- C1 -
1TQ8
-
Y1636_MYCTU
A:
[19-131]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
V
G
T
D
G
-
S
----
D
S
-
S
M
R
A
V
D
R
A
A
Q
I
A
G
A
D
A
-
K
L
I
I
A
S
A
Y
L
P
--------------
T
A
P
I
Y
E
I
L
H
D
A
K
E
---
R
A
H
N
A
G
A
K
N
V
E
E
-
R
P
I
V
G
A
P
V
D
A
L
V
N
L
A
D
E
-----
E
K
A
D
L
L
V
V
G
N
V
G
L
S
T
I
A
G
R
L
L
G
S
V
P
A
N
V
S
R
R
A
K
V
D
V
L
I
V
H
T
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
34.05
30%
242
- C1 -
1FTX
1
ALR_GEOSE
A:
[137-208]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
9
PsiBlast_PDB
34.02
30%
240
- C1 -
1L6G
1
ALR_GEOSE
A:
[138-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
7
PsiBlast_PDB
33.23
30%
243
- C1 -
2SFP
1
ALR_GEOSE
A:
[138-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
10
PsiBlast_PDB
32.70
30%
239
- C1 -
1NIU
1
ALR_GEOSE
A:
[138-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
8
PsiBlast_PDB
32.43
30%
242
- C1 -
1L6F
1
ALR_GEOSE
A:
[138-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
13
PsiBlast_PDB
31.96
30%
243
- C1 -
1XQK
1
ALR_GEOSE
A:
[138-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
V
K
D
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
-
W
L
P
S
R
P
P
-----
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
F
G
A
T
Y
T
A
Q
T
E
E
W
I