@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S12A6_HUMAN: (2015-12-09 )
MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
Atome Classification :
(20 SA)
.........10........20........30........40.....---...50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.....-..210.......220.......230.......240.......250........260..-.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370------.........380.......390.......400.......410---........420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530....--...540.......550.......560-.-......570.......580.......590.......600.......610.......620.......630....-------...640.......650.......660.......670.......680.......690......---.700----.........710.......720.......730.......740.......750.......760...-....770........780......-.790.......800..--.-.--------..-...810--.....---.---..820-------------...-...----..-.830.......840........850.......860.......870.......880......-.890.......900.......910----..--------...--------..920.......930---........940.......950.......960.......970.......980.......990...--....1000......1010......1020........1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHPPETTT
K
M
A
S
V
R
F
M
VTPTKIDDIPGLSDTSPDLSSRSS
S
R
V
R
FS---SRESVPETSRSE
P
M
S
E
MSGAT
T
S
L
A
T
V
A
LDPPSDRTS
H
P
Q
D
V
I
E
D
L
SQNSITG
E
H
S
Q
L
L
D
D
G
H
K
K
A
R
N
AYLNNSNY
E
E
G
D
E
Y
F
D
K
N
L
A
L
F
E
E
E
MDTR
P
K
V
S
S
L
L
N
R
M
A
N
Y
T
N
LTQG
A
K
E
H
E
E
A
E
N
ITEGKKKPTKTPQ
M
G
T
F
M
G
V
Y
L
P
C
L
Q
N
I
F
G
V
I
L
F
L
R
-
L
T
W
VVG
T
A
G
V
L
Q
A
F
A
I
V
L
I
C
C
C
C
T
M
L
T
A
I
S
M
S
A
IATNGVVPAG-G
S
Y
F
M
I
S
RALGPEF-GG
A
V
G
L
C
F
Y
L
G
T
T
F
A
A
A
M
Y
I
L
G
A
I
E
I
F
L
V
Y
IV
P
R
A
A
I
FHS
D
D
A
L
K
E
S
A
A
M
L
NNM
R
V
Y
G
T
A
F
L
V
L
M
V
L
V
V
F
I
G
V
R
Y
V
N
K
F
A
S
L
F
L
A
C
V
I
V
S
I
L
A
I
Y
A
G
A
I
KSSFAPP--------HF
P
V
C
M
LGNRTLSSR
H
I
D
V
C
S
K
T
KEINNMTV
P
S
K
L
W
G
F
FCN----S
S
Q
FFNA
T
C
D
E
Y
F
VHNNVTSIQGIP
G
L
A
S
G
I
I
T
E
N
L
W
S
NYLPKG
E
I
IEKPSAKSS
D
V
L
GSLNH
E
Y
V
L
V
D
ITT
S
F
T
L
L
V
G
I
F
FPS
V
T
G
IMAGSNRSG
D
L
K
D
A
Q
KSI
P
I
G
T
I
L
A
I
L
T
T
S
F
V
Y
L
S
N
V
V
--
L
F
G
A
C
IE
G
V
V
L
R
DKFGDAVKG
N
L
V
V
G
-T-LSWPS
P
W
V
I
V
I
G
S
F
F
S
T
C
G
A
G
L
Q
SLTG
A
P
R
L
L
Q
A
I
A
KDN
I
I
P
F
L
R
V
FGHSKANGEP
T
W
A
L
L
L
T
A
A
I
A
E
L
G
I
L
I
-------
A
S
L
D
L
V
A
P
I
L
S
M
F
F
L
M
C
Y
L
F
V
N
L
A
C
A
L
Q
T
L
L
RTPNWRPR
F
R
Y
Y
H
W
A
L
S
F
M
G
M
S
I
C
L
A
L
M
F
I
S
---
S
W
------
Y
Y
A
I
V
A
M
V
I
A
G
M
I
Y
K
Y
I
EYQGAE
K
E
WGDGIRGL
S
L
S
A
A
R
F
A
L
L
R
LEEGPPHTKNWR
P
Q
L
L
V
L
L
KL-DEDLHV-KH
P
R
L
L
T
F
A
S
Q
LKAGK
G
-
L
T
I
V
G
S
V
I
V
G
N
F
--
L
E
--
N
-
Y
--------
G
E
-
A
L
A
A
E
---
Q
T
I
K
H
---
L
---
M
E
A
---------------
E
K
V
-
K
G
F
----
C
Q
-
L
V
V
A
A
K
L
R
E
G
I
S
H
-
L
I
Q
S
CGLGGMKHN
T
V
V
M
GWPNGWRQS
E
D
A
R
A
W
K
T
F
IG
T
V
R
V
T
T
A
A
H
L
-
A
L
L
V
AKNISFFP
S
N
V
E
Q
FSEGN
I
D
----
V
W
--------
W
I
V--------HDG
G
M
L
M
L
L
P
F
L
L
K
----
Q
H
K
V
W
R
KC
S
I
R
I
F
T
V
A
QLEDN
S
I
Q
M
K
K
D
L
A
T
F
L
Y
H
L
R
I
E
A
E
V
E
V
V
E
MHDSDISA
Y
T
Y
E
R
T
L
M
M
E
--
Q
R
S
Q
M
L
R
H
M
RLSKTE
R
D
R
E
A
Q
L
V
K
D--RNS
M
L
R
L
TSIGSDE
D
E
E
T
E
T
Y
Q
E
K
V
H
M
T
WTK
D
K
Y
M
A
SRGQKA
K
S
M
E
G
F
Q
D
L
L
NMRP
D
Q
S
N
V
R
R
M
H
T
A
V
K
L
N
E
V
I
VNKSHE
A
K
L
V
L
L
NMPGPPRNPEG
D
E
N
Y
M
E
F
L
E
V
L
T
E
G
L
E
R
V
L
L
V
RGGG
S
E
V
I
T
I
YS
5
HHSearch
95.65
19%
-141
- C1 -
3GIA
7
Y609_METJA
A:
[3-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
-
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
-
I
V
S
N
A
-
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
--------------
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
-
H
P
S
---------------------------------------------------------------------------------------
Y
V
I
P
D
L
A
P
--------------------------
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
--
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
--
N
A
L
A
V
A
A
K
P
F
-
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
--
D
E
V
G
G
R
K
E
I
----
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
---
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
86.47
15%
-148
- C1 -
3L1L
2
ADIC_ECO57
A:
[7-430]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
K
V
G
L
I
P
V
T
L
M
-
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
S
-
T
G
G
-
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
-
D
P
S
P
G
-
G
S
Y
A
Y
A
R
R
C
F
G
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-
P
I
L
K
-------------
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
-
R
G
E
--------
T
Y
----------------------------------------------------
M
A
-------------------------------------------------------------
A
I
Q
S
T
L
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
--
A
I
M
G
M
I
P
N
A
A
L
R
V
S
-
A
--
S
P
F
G
D
A
A
R
-
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
--
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
-
G
H
F
G
K
A
R
P
---
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
---
G
A
K
E
V
---
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
80.36
16%
-90
* C1 *
3GIA
7
Y609_METJA
A:
[3-435]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
VSNA
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
NA
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
--
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
M
I
F
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
--
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
-
L
-
G
N
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
--
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
--------
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
---
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
54.52
17%
-54
- C1 -
4QCC
-
DGOA_ECOLI
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
L
P
L
I
A
I
L
R
G
I
T
P
D
E
A
-
L
A
H
V
G
A
V
I
D
A
G
F
D
A
V
E
--
I
-
P
--------
L
N
-
S
P
Q
W
E
---
Q
S
I
P
A
---
I
---
V
D
A
YGDKAL
I
G
A
G
TVLK
P
E
Q
V
-
D
A
L
A
R
M
G
C
Q
-
L
I
V
T
P
N
I
H
---
S
E
-
V
I
R
R
A
V
G
Y
G
M
---
T
V
C
P
G
C
A
T
---
A
T
E
A
F
T
A
L
E
A
G
A
Q
A
L
K
I
F
P
S
S
A
F
G
P
Q
Y
I
K
A
L
K
A
V
L
P
S
D
I
A
V
F
A
V
G
G
V
T
PEN
L
A
Q
--------
W
I
D
--------
A
G
C
A
G
A
G
L
G
S
D
L
Y
R
AGQS
V
E
R
T
A
Q
Q
A
A
A
F
V
K
A
Y
R
E
A
Q
K
Q
K
E
Q
R
Q
D
Q
K
S
A
Y
A
L
G
A
S
L
G
R
Y
M
E
N
S
L
K
E
Q
E
K
L
G
I
K
L
D
K
D
Q
L
I
A
G
--
V
Q
D
A
F
A
D
K
S
K
L
S
D
Q
E
I
E
Q
T
L
Q
A
F
E
A
------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
54.18
14%
-55
- C1 -
3G40
-
?
A:
[492-702]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
E
D
-
P
R
-----
E
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
K
G
-
S
V
K
L
L
G
L
A
------
D
K
--
E
-----------
N
-
L
L
S
Q
L
---
P
S
I
S
E
---
G
---
F
Q
E
---------------
E
G
V
-
F
S
S
----
W
T
-
I
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
E
N
R
D
R
D
------
E
E
I
R
E
I
I
R
K
A
S
M
Y
R
M
-
G
V
L
L
F
S
K
H
P
Q
A
----
G
L
G
R
Q
N
L
I
N
----
L
W
--------
I
E
N
RWDISMEL
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
----
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
K
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
51.62
14%
-47
- C1 -
3G40
-
?
A:
[492-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
A
N
L
L
V
P
V
-----
E
D
P
R
-
E
L
M
G
T
F
D
F
L
R
D
I
T
Y
P
K
G
-
S
V
K
L
L
G
L
A
D
K
-------------------
E
N
-
L
L
S
Q
L
---
P
S
I
S
E
---
G
---
F
Q
E
---------------
E
G
V
-
F
S
S
----
W
T
-
I
I
-----
E
E
N
L
V
V
-
G
M
E
A
L
T
G
S
F
F
R
P
S
I
L
F
L
R
L
P
------
E
N
R
D
R
D
E
E
I
R
E
I
I
R
K
A
S
M
Y
R
M
-
G
V
L
L
F
S
K
----
H
P
Q
A
G
L
G
R
Q
N
L
I
N
----
L
W
I
E
NRWDIS
M
E
L
--------
G
N
M
D
L
A
L
L
I
A
Y
K
L
K
----
S
N
W
---
K
A
S
L
S
F
M
T
F
A
P
T
A
I
Q
A
Q
A
A
E
N
F
L
Q
S
L
A
E
L
A
R
I
P
N
V
K
M
Q
V
L
R
E
N
P
I
K
S
S
K
L
P
F
A
S
L
H
I
F
S
L
D
P
N
P
D
L
D
L
A
R
H
L
M
E
K
A
G
S
S
C
I
F
A
L
D
SG
E
E
N
A
L
A
L
L
--------------------------------------------------------------------------------------------------------------------------
17
HHSearch
51.61
16%
-10
- C1 -
3FG9
2
?
A:
[17-130]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
L
T
V
D
E
-
D
D
--
N
T
-
S
S
E
R
A
F
R
Y
A
T
T
L
A
H
D
Y
D
V
P
L
G
I
C
S
V
L
E
S
E
D
--
I
N
--
I
-
F
DSL
T
P
S
K
I
Q
A
K
R
K
H
V
E
D
V
V
A
E
Y
V
Q
---
L
---
A
E
Q
---------------
R
G
V
N
Q
V
E
----
P
L
-
V
Y
E
G
G
D
V
D
D
V
I
L
E
Q
V
I
P
E
-----
F
K
P
D
L
L
V
T
G
A
D
T
E
F
P
H
S
K
I
A
G
A
I
G
P
R
L
A
R
K
A
P
I
S
V
I
V
V
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.61
27%
-14
- C1 -
3GIA
4
Y609_METJA
A:
[196-361]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
-
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.11
27%
-12
- C1 -
3GI9
-
Y609_METJA
C:
[196-361]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
-
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.70
27%
-13
- C1 -
3GI8
-
Y609_METJA
C:
[196-361]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
SA
I
G
N
L
P
I
D
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
-
N
-
L
G
F
---
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
---
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
---
F
V
------
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
47.13
18%
-13
- C1 -
3DLO
1
?
A:
[26-128]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
V
V
A
V
D
K
K
S
D
-----
R
A
E
R
V
L
R
F
A
A
E
E
A
R
L
R
G
V
P
V
Y
V
V
H
S
L
P
G
G
G
--
R
T
K
D
E
D
I
--------
I
E
-
A
K
E
T
L
---
S
W
A
V
S
---
I
---
I
R
K
---------------
E
G
A
-
E
G
E
----
E
H
L
L
V
R
G
K
E
P
P
D
D
I
V
D
-
F
A
D
E
-----
V
D
A
I
A
I
V
I
G
I
R
K
R
S
P
T
G
K
L
I
F
G
S
V
A
R
D
V
I
L
K
A
N
K
P
V
I
C
-
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
44.30
12%
-23
- C1 -
3MT0
-
?
A:
[9-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
V
V
I
E
P
-
D
Q
-----
L
E
G
L
A
L
K
R
A
Q
L
I
A
G
V
T
Q
S
H
L
H
L
L
V
C
E
K
R
R
-------------------
D
-
H
S
A
A
L
---
N
D
L
A
Q
---
E
---
L
R
E
---------------
E
G
Y
-
S
V
S
----
T
N
-
Q
A
W
K
D
S
L
H
Q
T
I
I
A
-
E
Q
Q
A
-----
E
G
C
G
L
I
I
K
Q
H
F
P
D
N
P
L
K
K
A
I
L
T
P
D
D
W
K
L
L
R
F
A
P
C
P
V
L
M
-
T
K
T
A
R
P
W
T
G
G
K
I
L
A
A
V
D
V
G
N
N
D
G
E
----
H
R
--------
S
L
H
--------
A
G
I
I
S
H
A
Y
D
I
A
G
L
A
----
K
A
T
L
H
V
I
S
A
H
P
T
F
Q
L
S
E
T
I
E
A
R
Y
R
E
A
C
R
T
F
Q
A
E
Y
G
F
S
D
E
Q
L
H
I
E
E
G
P
A
D
V
L
I
P
R
T
A
Q
K
L
D
A
V
V
T
--
V
I
G
T
V
A
R
T
G
L
S
G
A
L
I
G
N
T
A
E
V
V
L
D
T
--
L
E
S
D
V
L
V
L
K
P
D
D
I
I
A
H
L
E
E
L
A
S
K
E
----------------------------------------------------------------------------------------------------------
14
HHSearch
41.30
12%
-10
- C1 -
3FDX
3
?
A:
[3-117]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
L
V
P
I
D
I
-
S
D
---
K
E
F
T
E
R
I
I
S
H
V
E
S
E
A
R
I
D
D
A
E
V
H
F
L
T
V
I
P
S
-----------G
M
------
D
E
L
R
E
G
S
E
---
T
Q
L
K
E
---
I
A
K
K
F
S
I
---------------
P
E
D
-
R
M
H
----
F
H
-
V
A
E
-
G
S
P
K
D
K
I
L
A
-
L
A
K
S
-----
L
P
A
D
L
V
I
I
A
S
H
R
P
D
I
T
T
Y
L
L
G
S
N
A
A
A
V
V
R
H
A
E
C
S
V
L
V
V
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
38.95
11%
37
- C1 -
1TQ8
-
Y1636_MYCTU
A:
[19-131]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
V
G
T
D
G
-
S
D
-----
S
S
M
R
A
V
D
R
A
A
Q
I
A
G
A
D
A
-
K
L
I
I
A
S
A
Y
L
P
----------------------
T
A
P
I
Y
---
E
I
L
H
D
A
K
E
R
---
A
H
N
---------------
A
G
A
-
K
N
V
----
E
E
-
R
P
I
V
G
A
P
V
D
A
L
V
N
-
L
A
D
E
-----
E
K
A
D
L
L
V
V
G
N
V
G
L
S
T
I
A
G
R
L
L
G
S
V
P
A
N
V
S
R
R
A
K
V
D
V
L
I
-
V
H
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
36.06
13%
270
- C1 -
1IC2
-
TPM1_CHICK
A:
[1-79]
-----------------------------------------------------------------------------------------------------------
M
D
A
I
K
K
K
M
Q
M
L
K
L
D
K
E
N
A
L
D
R
A
E
Q
A
E
A
D
K
K
A
A
E
E
R
S
K
Q
L
E
D
E
L
V
A
L
Q
K
K
L
K
G
T
E
D
E
L
D
K
Y
S
E
S
L
K
D
A
Q
E
K
L
E
L
A
D
K
K
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
34.87
11%
-104
- C1 -
2JLN
-
?
A:
[21-181]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
-
W
F
A
M
A
I
Q
V
A
I
F
I
A
A
G
Q
M
T
S
S
F
Q
-
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
----
R
W
G
I
N
F
T
V
A
A
R
M
P
F
G
I
R
G
-
S
L
I
P
I
T
L
K
A
L
L
S
L
F
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
-
R
L
L
T
G
F
-------------
T
N
L
P
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
--------
G
E
V
M
S
M
G
G
E
N
P
G
M
P
F
S
T
A
I
M
I
F
V
G
G
W
I
A
V
V
V
S
I
H
D
I
V
K
E
C
K
----
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
A
A
S
M
V
L
V
G
E
W
N
P
V
I
A
I
T
E
V
V
G
G
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
F
A
G
V
L
N
--
T
F
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
-
R
-
R
I
S
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
-------
R
N
E
D
Y
L
R
P
I
G
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
31.30
15%
306
- C1 -
3QH9
1
A:
[14-79]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
E
K
Q
R
K
A
E
E
L
L
Q
E
--
L
R
H
L
K
I
K
V
E
E
L
E
N
E
R
N
Q
Y
E
W
K
L
K
A
T
--
K
A
E
V
A
Q
L
Q
E
Q
V
A
L
K
D
A
E
I
E
R
L
H
S
Q
L
S
R
-------------------------------------------------------------------------------------------------------
24
Fugue
29.41
12%
280
- C1 -
4JPN
-
H_BPPHS
A:
[2-76]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
G
F
--
E
N
Q
K
E
L
T
K
M
Q
L
D
N
Q
K
E
I
A
E
M
Q
N
-
E
T
--
Q
K
E
I
A
G
I
Q
S
A
T
S
R
Q
N
T
K
D
Q
V
Y
A
Q
N
E
M
L
A
Y
Q
Q
K
E
S
T
A
R
V
A
S
I
M
E
N
T
N
------------------------------------------------------------------------------------
4
PsiBlast_PDB
26.89
33%
493
* C2 *
3V2I
1
PTH_BURTA
A:
[137-192]
---------------------------
L
K
D
I
S
A
H
L
S
S
Q
Q
Y
W
R
L
R
I
G
IGH
P
R
D
M
I
P
----------------
D
V
A
N
F
V
L
K
P
P
R
---
K
E
E
Q
D
V
I
D
A
A
I
E
R
A
L
A
V
M
P
A
V
V
K
G
E
T
E
R
A
M
M
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
24.79
19%
298
- C1 -
3WMI
-
?
A:
[1-57]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
E
N
L
Y
F
Q
S
N
A
D
S
V
Q
N
H
T
F
E
V
E
N
N
T
I
N
G
L
E
L
V
E
--
E
Q
V
H
I
L
Y
A
M
V
L
---
Q
T
H
A
D
V
Q
L
L
K
E
--
Q
Q
--------------------------------------------------------------------------------------------------------------------------------