@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S12A8_HUMAN: (2015-12-09 )
MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
Atome Classification :
(20 SA)
.........10........20........30........40........50-........60...--.....70........80........90........100-........110...-...-.120.......-------130-...--.....140.......150.----.......160.......170.......180.......190.......200....-...210..---.------....---220.....--.---.230.---.-...-.--.240.......250.......260.......270.......280......---..290-.---------------...-------.--.---.--300.---..-.--.-.--..310.......--320.....-..330--.........340.......350.......360.......370.....-------..380.......390.......400.......410.-......420.......430.----......440.......450..-.....460.......470.......480.......490.......500.......510.......520.......530.......540.......550......----.560.......-570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
Q
M
S
Q
V
Q
E
L
F
H
E
A
A
Q
QDALAQPQPW
W
K
T
Q
L
F
M
WEPV
L
F
GT
W
D
G
V
F
T
S
C
M
I
-
N
I
F
G
V
V
L
F
L
RTG
W
--
L
VG
N
T
G
V
L
L
G
M
F
L
V
S
F
V
I
L
V
A
L
V
T
V
L
S
GIGVGERSSI--GS
G
G
V
Y
S
M
I
S
S
V
LG-GQT-G
G
T
I
G
L
L
Y
V
F
G
-------
Q
-
C
-VAG--
A
M
Y
I
T
G
F
A
E
S
I
S
D
L
L
G-LG----
N
I
W
A
VR
G
I
S
V
A
V
L
L
A
L
LGI
N
L
A
G
V
K
W
I
I
R
L
Q
L
L
L
L
F
L
L
A
V
S
T
L
D
F
V
V
G
S
FTHLD-PEHGFIGY---
S
------
P
E
L
L---QNNTLPDY--S---P
G
E
S
F
---
F
-
T
V
F
-
G
--
V
F
F
P
A
A
T
G
V
M
A
GFNMGGDLREPAASIP
L
G
S
L
A
A
V
G
I
S
W
F
L
Y
I
-
I
F
V
F
L
L
G
---
A
I
C
T
R
-
E
---------------
A
L
R
-------
Y
--
D
---
F
--
L
-
I
A
---
E
K
-
V
--
S
-
L
--
M
G
F
L
F
L
L
G
L
Y
I
S
--
S
L
A
S
C
M
G
G-LY
G
----
A
P
R
I
L
Q
C
I
A
QEK
V
I
P
A
L
A
C
LGQGKGPNKT
P
V
A
A
I
C
L
T
S
L
V
T
M
A
F
V
F
V-------GQ
V
N
V
L
A
P
I
V
T
I
N
F
M
L
T
Y
V
A
V
D
Y
S
Y
F
S
L
S
MCSCSLT-PV
P
E
P
V
L
R
EGAEGLHC
S
E
H
L
----
L
LEKAPSYGSE
G
P
A
Q
R
V
L
E
G
T
-
L
L
E
F
T
K
D
M
D
Q
L
L
Q
L
T
R
K
L
ESSQPRQGEGNRT
P
E
S
Q
K
R
K
S
K
K
A
T
K
Q
T
L
Q
D
S
F
L
L
DLKSPPSF
P
V
EISDRLPAASWE
G
Q
E
S
C
WNKQTSKSEGTQPEGT
Y
G
E
Q
L
V
P
E
----
L
CNQSESSGE
D
-
F
F
L
K
S
R
L
Q
E
Q
D
V
W
R
RST
S
F
Y
T
HMC
N
P
W
V
S
L
L
G
A
V
G
S
L
L
I
M
F
V
I
Q
W
V
Y
T
L
V
N
M
G
V
A
A
I
V
Y
F
Y
IGRASPGLHLGSASN
F
S
F
F
R
W
M
R
S
L
L
L
P
S
C
R
S
LRSPQ
E
Q
I
I
LAP
S
L
A
K
V
D
M
E
M
T
Q
L
T
QENADFATRDRY
H
H
S
S
LV
N
R
E
QLMPHY
7
PsiBlast_PDB
92.46
21%
-136
- C2 -
3GI8
-
Y609_METJA
C:
[7-365]
-----------------------------
K
L
S
L
W
E
A
V
S
M
A
V
--
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
--
N
L
P
E
T
F
I
L
S
G
I
Y
--------
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
-
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-------
Y
-
V
-
I
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
-
A
P
I---
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
---
F
I
V
L
V
A
L
L
--
I
L
G
L
F
I
F
A
-----
G
L
I
T
I
---
H
------
P
S
Y
V
-------
I
P
D
L
--
A
---
P
S
A
V
S
---
G
-
M
I
F
-
A
SA
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
-
E
---------------
L
I
K
-------
A
--
S
ENA
L
--
A
-
V
A
---
A
K
-
P
--
F
-
L
GN
L
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
---
E
R
K
V
W
F
K
S
-
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
-
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.28
19%
-133
- C2 -
3GI9
-
Y609_METJA
C:
[7-365]
-----------------------------
K
L
S
L
W
E
A
V
S
M
A
V
--
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
--
N
L
P
E
T
F
I
L
S
G
I
Y
--------
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
-
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-------
Y
-
V
-
I
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
--
A
P
I---
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
-------------------------
V
I
P
D
L
--
A
---
P
S
A
V
S
---
G
-
M
I
F
-
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
-
E
---------------
L
I
K
-------
A
--
S
EN
A
L
--
A
-
V
A
---
A
K
-
P
--
F
-
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
---
E
R
K
V
W
F
K
S
-
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
-
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.78
19%
-135
- C2 -
3GIA
6
Y609_METJA
A:
[7-365]
-----------------------------
K
L
S
L
W
E
A
V
S
M
A
V
--
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
-
A
G
R
--
N
L
P
E
T
F
I
L
S
G
I
Y
--------
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-
V
--
S
N
A
G
P
I
A
F
I
H
K
A
I
G
-
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-------
Y
-
V
-
I
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
-
A
P
I---
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
-------------------------
V
I
P
D
L
--
A
---
P
S
A
V
S
---
G
-
M
I
F
-
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
---
N
L
P
I
D
-
E
---------------
L
I
K
-------
A
--
S
EN
A
L
--
A
-
V
A
---
A
K
-
P
--
F
-
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
--
S
I
S
S
A
M
N
A
T
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
---
E
R
K
V
W
F
K
S
-
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
-
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.06
20%
-141
- C2 -
3L1L
2
ADIC_ECO57
A:
[23-352]
-----------------------------------------------------
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
-----
G
G
S
Y
A
Y
A
R
R
C
F
G
-
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
---------
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
-
L
K
----
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
T
Y
M
A
-----------------------
A
I
Q
S
--
T
---
L
N
V
T
L
---
W
-
S
F
I
-
G
--
V
---
E
S
A
S
V
A
A
G
V
-----
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
-
L
S
T
T
A
I
M
---
G
M
I
P
N
-
A
---------------
A
L
R
-------
V
--
S
---
A
--
S
-
P
F
---
G
D
-
A
--
A
-
R
--
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
-
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
---
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
-----------
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
-
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
----
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
-
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
82.14
17%
-143
- C2 -
3GIA
6
Y609_METJA
A:
[4-368]
----------------------------------
K
N
K
K
L
S
L
W
E
A
V
S
M
-
A
V
G
-
V
M
I
G
A
S
I
F
S
I
F
G
V
--
G
A
K
I
A
G
R
N
---
L
P
E
T
-
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
-
D
N
I
I
T
G
A
L
S
I
L
L
W
M
S
-------
Y
-
V
-
I
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
-
A
P
I---
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
V
I
P
D
L
---------------------
A
P
----
S
---
A
V
S
G
M
---
I
-
F
A
S
-
A
--
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
-
G
V
A
I
S
A
I
---
G
N
L
P
I
-
D
---------------
E
L
I
-------
K
A
S
E
---
N
--
A
-
L
A
V
A
A
K
P
F
L
G-
N
-
L
--
G
F
L
L
I
S
I
G
A
L
F
S
--
I
S
S
A
M
N
A
T
-
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
--
F
F
E
R
K
V
-
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
-
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
81.78
16%
-149
- C2 -
3L1L
2
ADIC_ECO57
A:
[9-379]
-------------------------------------
K
V
G
L
I
P
V
T
L
M
-
V
S
G
-
A
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
T
-
G
G
I
---
A
I
Y
G
-
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
DP
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
-
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
-------
C
-
W
-
I
G
N
--
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
-
I
L
K---
D
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
T
Y
M
A
------------------------------------
A
I
---
Q
-
S
T
L
-
N
--
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
-
L
S
T
T
A
I
M
---
G
M
I
P
N
-
A
---------------
A
L
R
-------
V
S-
A
---
S
--
P
-
F
G
D
A
A
R
M
-
A
LG
D
-
T
--
A
G
A
I
V
S
F
C
A
A
A
G
--
C
L
G
S
L
G
G
W
-
T
L
L
----
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
--
I
F
A
R
V
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
-
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
----
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
-
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
81.45
13%
-109
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------
L
K
N
K
K
L
S
L
W
E
A
-
V
S
M
A
V
G
V
M
I
G
A
S
I
FS
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
-
T
G
A
L
S
I
L
L
W
M
S
-------
Y
-
V
-
I
S
I
--
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
----
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
-
P
S
Y
----
V
---
I
------
P
----------
D
L
A
P
--
S
---
A
V
S
G
M
---
I
-
F
A
S
-
A
--
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
-
G
V
A
I
S
A
I
---
G
N
L
P
I
-
D
---------------
E
L
I
K
A
SEN
A
L
A
--
V
---
A
--
A
-
K
P
---
F
L
-
G
--
N
-
L
--
G
F
L
L
I
S
I
G
A
L
F
S
--
I
S
S
A
M
N
A
T
-
I
Y
G
----
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
----
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
-
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
----
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.77
20%
-128
- C2 -
3LRB
-
ADIC_ECO57
A:
[22-352]
----------------------------------------------------
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
-----
G
G
S
Y
A
Y
A
R
R
C
F
G
-
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
-
V
-
V
I
G
--
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
-
L
T
----
I
T
------
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
T
Y
M
A
A
W
---
N
------
V
S
G
L
---
G
T
F
G
A
I
Q
S
--
T
---
L
N
V
T
L
---
W
-
S
F
I
-
G
--
V
---
E
S
A
S
V
A
A
G
V
-----
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
-
L
S
T
T
A
I
M
---
G
M
I
P
N
------------------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
-
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
---
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
-----------
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
-
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
----
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
-
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.69
21%
-134
- C2 -
3NCY
-
ADIC_SALTY
A:
[22-339]
----------------------------------------------------
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
A
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
A
L
S
M
V
Y
A
K
M
S
S
L
D
P
S
P
-----
G
G
S
Y
A
Y
A
R
R
C
F
G
-
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
-
V
-
V
I
G
--
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
-
L
----------
T
L
T
C
V
A
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
W
F
W
F
K
-
G
E
-----
W
---
N
------
V
S
G
M
-----
N
T
F
-----------
G
A
I
---
Q
-
S
T
L
-
N
--
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
-
L
S
T
T
A
I
M
---
G
M
I
P
N
-
A
---------------
A
L
R
-------
V
--
S
---
A
--
S
-
P
F
---
G
D
-
A
--
A
-
R
--
M
A
L
G
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
-
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
--------
T
P
V
A
G
L
L
I
V
G
V
L
M
T
I
F
Q
F
S
-------
S
M
S
P
N
A
A
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
-
H
G
H
F
G
K
A
R
P
L
Y
L
L
I
T
F
V
A
F
V
----
Y
C
I
W
A
V
I
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-
M
V
I
T
A
L
Y
A
L
N
Y
N
R
I
H
K
N
P
Y
P
L
D
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.49
20%
-123
- C2 -
3LRC
-
ADIC_ECO57
A:
[22-352]
----------------------------------------------------
N
I
M
G
S
G
V
F
L
L
P
A
N
--
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
S
P
-----
G
G
S
Y
A
Y
A
R
R
C
F
G
-
P
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
W
I
G
N
I
A
M
-
V
-
V
I
G
--
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
L
V
-
L
T
----
I
T
------
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
-
G
E
T
Y
M
A
A
W
---
N
------
V
S
G
L
---
G
T
F
G
A
I
Q
S
--
T
---
L
N
V
T
L
---
W
-
S
F
I
-
G
--
V
---
E
S
A
S
V
A
A
G
V
-----
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
-
L
S
T
T
A
I
M
---
G
M
I
P
N
------------------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
-
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
---
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
-----------
Q
L
S
S
I
S
P
N
A
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
-
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
----
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
-
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
55.78
10%
-133
- C2 -
2XQ2
3
SGLT_VIBPH
A:
[60-385]
------------------------------------------------
L
I
A
-
A
N
I
S
A
E
Q
F
I
G
M
S
G
--
S
G
Y
S
I
G
L
A
--
I
A
S
Y
E
--
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
-
K
T
I
L
A
V
F
W
I
S
L
-------
Y
-
I
F
V
N
L
--
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
-
I
P
-----
L
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
---
S
K
M
V
D
A
A
P
G
H
F
EMI
L
D
Q
S
N
P
Q
Y
--
M
---
N
L
P
G
I
AVL
I
G
G
L
W
-
V
--
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
-
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GNLP------
S
A
A
N------
A
--
D
---
K
A
Y
P
W
L
T
---
Q
F
-
L
--
P
V
G
--
V
K
G
V
V
F
A
A
L
A
A
A
--
I
V
S
S
L
A
S
M
-
L
N
S
----
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
M
-------
L
G
G
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
-
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
----
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
-
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
46.33
25%
-42
- C1 -
2JIF
2
ACDSB_HUMAN
A:
[112-223]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
G
D
Y
-----
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
-----
I
G
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
23
HHSearch
41.90
10%
-96
- C2 -
3DH4
1
?
A:
[65-356]
------------------------------------------------
L
I
A
-
A
N
I
S
A
E
Q
F
I
G
M
S
G
--
S
G
Y
S
I
G
L
A
--
I
A
S
Y
E
--
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
-
K
K
L
-
K
T
I
L
A
V
F
W
I
S
L
-------
Y
I
F
-
V
N
L
--
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
-
I
P
-----
L
M
--
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
---
P
G
H
F
-----
E
M
I
L
D
Q
SN
P
QYM
N
L
P
G
I
AVL
I
-
G
G
L
W
V
--
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
-
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
-
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
N------
A
--
D
---
K
A
Y
P
W
L
T
---
Q
F
-
L
--
P
V
G
--
V
K
G
V
V
F
A
A
L
A
A
A
--
I
V
S
S
L
A
S
M
-
L
N
S
----
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
-------
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
-
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
----
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
-
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.08
33%
124
- C1 -
4MHC
-
NU157_YEAST
A:
[468-521]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
----
L
Y
V
S
A
P
D
Y
G
I
L
K
N
Y
G
K
Y
V
E
N
T
A
L
L
D
T
T
D
E
I
K
E
I
V
P
L
T
R
S
F
N
Y
T
S
T
P
Q
G
Y
A
N
V
F
A
S
Q
Y
S
A
E
P
L
K
V
A
V
L
T
S
N
A
L
E
I
Y
C
Y
R
T
P
D
E
V
F
E
S
L
I
E
N
P
L
P
F
I
H
S
Y
G
L
S
E
A
C
S
T
A
L
Y
L
A
C
K
F
N
K
S
E
H
I
K
S
S
A
L
A
----
F
F
S
A
G
I
P
G
V
V
E
-
I
K
P
K
S
V
L
S
P
R
F
Y
G
S
A
L
L
I
T
R
L
F
S
Q
I
W
E
E
R
V
F
V
G
I
S
I
T
R
P
Q
V
E
Y
Y
L
S
S
I
S
V
L
A
D
F
F
N
I
H
R
P
S
F
V
S
T
A
S
D
A
E
S
I
A
M
N
A
L
I
L
L
I
N
S
I
K
D
A
L
S
L
I
N
V
F
Y
E
D
I
D
A
F
K
S
L
L
N
T
L
M
Y
D
S
K
T
R
E
Y
F
F
D
L
K
F
H
D
L
F
T
P
N
A
K
T
K
Q
L
I
K
E
I
L
I
E
V
V
34
Fugue
38.11
6%
12
- C2 -
4Y66
-
?
D:
[8-225]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
A
A
V
K
E
L
M
Q
T
S
N
K
P
Q
N
V
Q
T
A
I
N
N
T
G
S
K
Y
G
K
T
T
V
Q
K
A
L
D
E
L
V
A
Q
N
L
C
IYLY
L
W
N
Q
N
L
L
E
V
L
S
D
A
Q
L
M
E
V
N
A
Q
-
I
N
D
L
K
A
Q
V
E
K
L
T
Q
Q
G
E
T
L
R
I
T
Q
R
N
L
E
A
A
P
I
T
E
V
L
K
Q
E
V
D
E
L
R
Q
Q
V
S
A
N
D
E
K
L
R
L
V
R
E
S
N
A
I
V
S
D
A
D
M
L
T
L
Q
K
N
Y
K
D
A
M
T
A
W
A
T
R
R
A
K
C
R
E
V
I
D
T
L
S
E
G
M
G
V
K
P
S
----
A
F
M
D
Q
L
G
L
E
E
G
-
L
P
M
T
T
Y
T
E
M
K
K
A
L
P
P
V
N
V
A
D
I
----------------------------------------------------------------------------------------------------------------------------
35
Fugue
37.79
13%
84
- C2 -
2FCW
2
A:
[1-106]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
F
E
E
P
R
V
I
D
----
L
W
D
L
A
Q
S
A
N
L
T
D
K
E
L
E
A
F
R
E
E
-
L
K
H
F
E
A
K
I
E
K
H
N
H
Y
Q
K
Q
L
E
I
A
H
E
K
L
R
H
A
E
S
V
G
D
G
E
R
V
S
R
S
R
E
K
H
A
L
L
E
G
R
T
K
E
L
G
Y
T
V
K
K
H
L
Q
D
L
S
G
R
I
S
R
A
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
34.18
10%
-74
- C2 -
2JLN
-
?
A:
[67-184]
-------------------------------------------------------------------------------------
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
--
W
G
I
N
F
T
V
A
A
R
M
P
F
G
-
I
R
G
-
S
L
I
P
I
T
L
K
A
L
L
-------
S
-
L
-
F
W
F
--
G
F
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
-
L
L
TGFT
N
L
P
---
L
W
I
V
I
F
G
A
I
Q
V
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
-
V
S
L
G
E
V
M
S
---
M
------
G
G
E
N
---
P
G
M
P
F
S
T
A
--
I
---
M
I
F
V
G
---
G
-
W
I
A
-
V
--
V
V
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
-
I
F
G
F
I
G
A
---
A
S
M
V
L
-
V
---------------
G
E
W
-------
N
--
P
---
V
--
I
-
A
I
---
T
E
-
V
--
V
-
G
--
G
V
S
I
P
M
A
I
L
F
Q
V
--
F
V
L
L
A
T
W
S
-
T
N
P
----
A
A
N
L
L
S
P
A
Y
T
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
I
V
S
A
V
V
G
L
L
M
M
P
W
Q
F
A
G
V
L
N
T
F
-------
L
N
L
L
A
S
A
L
G
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
R
I
S
L
H
D
L
Y
R
T
K
-
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
----
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
-
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
R
P
I
G
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
33.15
12%
292
- C2 -
4C7N
-
A:
[2-48]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
S
V
D
Y
I
R
K
L
Q
R
E
Q
Q
R
A
K
E
L
E
N
R
Q
K
K
L
E
H
A
N
R
H
L
L
L
R
I
Q
E
L
E
M
Q
A
R
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
32.94
8%
65
- C2 -
2P22
-
SRN2_YEAST
C:
[1-192]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
D
I
I
R
A
E
M
D
V
V
P
S
P
G
L
-
P
S
K
N
I
P
L
P
E
G
I
N
L
L
S
S
K
E
I
I
----
D
L
I
Q
T
H
R
H
Q
L
E
L
Y
V
T
K
F
--
N
P
-
L
T
D
F
A
G
K
I
H
A
F
R
D
Q
F
K
Q
L
E
E
N
F
E
D
L
H
E
Q
K
D
K
V
Q
A
L
L
E
N
A
R
I
L
E
S
K
Y
V
A
S
W
Q
D
Y
H
S
E
F
S
K
K
Y
G
D
I
A
L
K
K
K
L
E
Q
N
T
K
K
L
D
E
E
S
S
Q
L
E
T
T
T
R
S
I
D
S
A
D
D
L
-
D
Q
F
I
K
N
----
Y
L
D
I
R
T
Q
Y
H
L
R
-
R
E
K
L
A
T
W
D
K
Q
G
N
L
K
Y
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
32.92
37%
73
- C3 -
4RDX
2
SYH_THET2
A:
[278-323]
-------------------------------------------------------------------------------------------------
I
G
A
Q
S
A
L
--
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
-
G
P
R
-
V
P
G
V
G
--
F
A
F
G
V
------
E
-
R
-
V
A
L
--
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
-
L
Y
----
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
-
D
E
L
R
A
G
E
V
---
T
------
L
K
R
L
---
A
T
G
E
Q
V
R
L
--
S
---
R
E
E
V
P
---
G
-
Y
L
L
-
Q
--
A
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------