@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S13A1_HUMAN: (2015-12-09 )
MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDTGKISSKVELEKNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFATDSTVALLIGLLFFLIPAKTLTKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAMSNETMP
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-----.......--150.......---160.......170.--......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..-.....390.......400.......410.......420.......430.......440.......450.......460.......470........480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
F
F
S
Y
I
L
V
Y
R
R
F
L
F
V
V
F
T
V
L
V
L
LPL
P
I
V
L
HTKEAE
C
A
Y
T
L
F
V
V
A
T
F
W
L
TEAL
P
L
S
V
T
A
L
L
P
S
L
M
L
P
M
FGIMP
S
K
K
V
A
S
A
Y
F
K
D
F
H
L
L
L
I
G
V
I
C
L
ATS
I
E
K
W
N
L
H
K
R
I
A
L
K
M
V
M
MVGV
N
P
A
W
L
T
L
G
F
MS
S
T
A
F
L
S
M
W
L
SNTS-----TA
A
M
V
M
P
--
I
A
E
A
V
V
Q
Q
I
I---NAEA
E
V
E
A
T
Q
M
T
Y
F--NGSTNHGLEIDESVNGHE
I
N
E
R
KEKTKPVPGYNNDTGKI
S
S
K
V
E
L
EKNSGMRT
K
Y
RTKKGH
V
T
R
K
L
T
C
L
C
I
A
YSSTIG
G
L
T
T
ITGTST
N
L
I
F
A
E
Y
FNTRYPD
C
R
C
LNFG
S
W
F
T
F
S
F
P
A
A
L
I
I
L
L
L
S
W
I
W
L
Q
W
L
F
LGF
N
F
K
E
M
F
KCGKTK
T
V
Q
Q
K
A
C
A
E
V
I
K
Q
E
Y
Q
KLG
P
I
R
Y
Q
E
I
V
T
L
V
L
F
I
I
M
A
L
L
WFSRDPGFVP
G
W
S
A
L
F
S
EYPGFAT-
D
S
T
V
A
L
L
I
G
L
L
F
F
L
IP
A
K
T
LTKTTPT
G
E
I
V
A
F
DYSPLI
T
W
K
E
F
Q
SFMP
W
D
I
A
I
L
VGGGFALADG
C
E
ES
G
L
S
K
W
IGNKLSPLGS
L
P
A
-
W
L
I
I
L
I
S
S
L
M
V
T
S
L
T
E
VASNP
A
T
I
T
L
F
L
P
I
L
S
P
L
A
E
A
IHVN
P
L
Y
I
L
I
P
S
T
L
C
T
S
F
A
F
L
LPVANPP
N
A
I
V
F
SYG
H
L
K
V
I
D
M
V
K
AGLG
V
N
I
V
G
V
A
V
V
M
L
G
I
C
T
W
I
V
P
M
F
D
LYTYPSWAPAMSNETMP
1
PsiBlast_PDB
92.06
27%
-121
- C5 -
4F35
-
?
D:
[154-447]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
V
D
A
D
K
Q
R
S
T
Y
V
F
V
L
L
G
V
A
Y
S
A
S
I
G
G
I
A
T
L
V
G
S
P
P
N
A
I
A
A
A
E
V
G
L
S
F
T
D
--------
W
M
K
F
G
L
P
T
A
M
M
M
L
P
M
A
-
I
A
I
L
Y
F
L
L
--------------
V
N
W
D
K
G
------------------
K
V
V
T
L
G
I
F
G
L
T
V
F
L
W
I
F
S
S
P
--------
I
N
A
A
L
G
G
F
K
S
F
D
T
L
V
A
L
--------------------
G
A
I
L
M
L
S
F
A
R
V
V
H
W
K
E
I
Q
K
T
A
D
W
G
V
L
L
L
F
G
G
G
L
C
L
S
N
V
L
K
Q
T
G
T
S
V
F
L
A
N
A
L
S
D
M
V
S
H
M
G
I
F
V
V
I
L
V
V
A
T
F
V
V
F
L
T
E
F
A
S
N
T
A
S
A
A
L
L
I
P
V
F
A
T
V
A
E
A
F
G
M
S
P
V
L
L
S
V
L
I
A
V
A
A
S
C
A
F
M
L
P
V
A
T
P
P
N
A
I
V
F
A
S
G
H
I
K
Q
S
E
M
M
R
V
G
L
Y
L
N
I
-----
A
C
I
G
L
L
T
A
I
A
M
L
F
W
Q
----------------
2
PsiBlast_PDB
50.32
27%
-17
- C5 -
2YXZ
-
?
A:
[50-151]
-------------------------------------------------------------------------------------------------------
L
Y
R
E
V
A
L
K
-----
G
M
G
P
--
F
E
V
G
F
R
G
V
A
A
T
A
S
D
L
L
A
K
M
G
RPL
G
F
T
L
G
L
F
L
P
ED
L
E
E
G
F
V
L
E
L
V
---
R
G
A
A
E
A
-
A
K
R
L
G
A
F
LL
G
G
D
T
N
R
G
V
E
V
A
L
T
V
S
G
Y
A
L
A
E
A
P
L
P
R
K
A
L
P
G
D
L
L
Y
L
A
G
D
R
W
G
R
T
G
A
A
I
R
A
H
Y
E
G
R
S
L
E
G
F
P
K
I
R
E
A
A
F
Y
P
L
P
R
L
E
L
L
A
L
S
G
L
L
R
G
S
L
D
S
S
D
G
L
A
E
T
L
W
Q
L
A
D
L
G
V
G
V
E
V
E
A
L
P
L
Y
P
D
V
L
A
F
A
G
S
E
E
A
A
L
E
L
V
L
Y
G
G
E
E
F
E
A
V
L
V
V
P
Q
E
G
A
A
A
V
E
A
R
A
K
A
K
G
L
P
L
F
R
A
G
R
V
V
A
G
E
G
V
Y
L
R
G
A
P
L
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
41.17
14%
97
- C5 -
2L8T
-
?
A:
[2-72]
------------------------------------------------------------------------------------------------------------------------------------
E
T
K
Y
E
L
N
N
T
K
-----
K
V
A
N
A
F
G
--
L
N
E
E
D
T
N
L
L
I
---
N
A
V
D
L
D
I
K
N
N
M
Q
E
I
--
S
S
E
L
Q
Q
S
E
Q
S
K
Q
K
Q
Y
G
T
T
L
Q
N
L
A
K
Q
N
R
I
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
39.86
17%
119
- C5 -
1NYH
-
SIR4_YEAST
A:
[1271-1346]
----------------------------------------------------------------------------------------------------------------------------------
L
S
F
V
D
I
V
L
S
K
A
A
-----
S
A
L
D
E
K
E
--
K
Q
L
A
V
A
N
E
I
I
R
S
L
S
D
E
V
M
R
N
E
I
R
I
T
S
L
--
Q
G
D
L
T
F
T
K
K
C
L
E
N
A
R
S
Q
I
S
E
K
D
A
K
I
N
K
L
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
38.82
21%
346
* C5 *
1KIL
-
CPLX1_RAT
E:
[9-49]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
E
E
R
Q
E
A
L
R
Q
A
E
E
E
R
K
A
K
Y
A
K
M
E
A
E
R
E
V
-
M
R
Q
G
I
R
D
K
Y
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
38.44
13%
86
- C5 -
1W9R
-
?
A:
[1-119]
------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
-----
P
E
K
K
V
A
E
--
A
E
K
K
V
E
E
A
K
K
---
K
A
E
D
Q
K
E
E
D
R
R
N
Y
---
P
T
N
T
Y
K
T
L
E
L
E
I
A
E
S
D
V
E
V
K
K
A
E
L
E
L
V
K
E
E
A
K
E
P
R
N
E
E
K
V
K
Q
A
K
A
E
V
E
S
K
K
A
E
A
T
R
L
E
K
I
K
T
D
R
K
K
A
E
E
E
A
K
R
K
A
A
E
E
D
K
V
K
E
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
32.55
33%
363
- C4 -
3NAP
-
?
B:
[19-42]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
E
Q
R
S
Q
E
K
V
Q
A
G
E
I
N
E
S
I
E
F
R
N
Q
I
T
T
F
V
H
D
N
P
I
I
T
E
Q
L
I
G
D
S
P
Q
P
S
G
D
V
R
S
V
S
D
A
R
T
H
S
I
I
D
F
L
E
R
P
Q
F
I
G
S
F
L
W
N
T
S
D
I
E
N
K
E
I
F
S
L
K
L
P
D
A
L
M
S
P
M
I
R
E
K
L
S
G
F
T
S
F
S
A
S
T
V
F
H
I
Q
V
N
A
H
P
F
Q
C
G
R
L
V
L
A
A
V
P
V
P
D
I
L
P
L
H
R
L
N
M
L
S
F
D
V
S
N
V
I
T
L
P
H
V
Q
L
D
I
S
K
E
T
E
V
L
L
K
I
P
Y
V
S
P
F
V
Q
Y
D
L
V
T
K
F
T
P
W
A
A
F
L
A
H
V
Y
A
P
L
N
T
-
P
S
A
A
S
L
Q
V
N
V
F
A
H
F
E
D
I
K
L
G
F
P
T
S
A
I
V
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
31.56
5%
145
- C5 -
2KZ9
-
VATE_YEAST
A:
[1-69]
----------------------------------------------------------------------------------------------------------------------------------
M
A
S
A
I
T
A
L
T
P
N
Q
-----
V
N
D
E
L
N
K
--
M
Q
A
F
I
R
K
E
A
E
---
E
K
A
K
E
I
Q
L
K
A
D
Q
E
Y
--
E
I
E
K
T
N
I
V
R
N
E
T
N
N
I
D
G
N
F
K
S
K
L
K
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
29.61
9%
324
- C5 -
2HEP
-
YNZC_BACSU
A:
[1-42]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
S
N
A
K
I
A
R
I
N
E
L
A
A
K
A
K
A
G
V
I
--
T
E
E
E
K
A
E
Q
Q
K
L
R
Q
E
Y
L
K
G
F
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
24.67
20%
679
- C5 -
3S8F
4
COXA_THET8
C:
[18-32]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
V
F
W
L
G
V
Y
A
V
F
F
A
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
23.63
8%
1295
- C5 -
1PSM
-
?
A:
[12-23]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
Q
A
A
K
D
A
E
N
A
S
K
E
A
E
E
A
A
K
E
A
V
N
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
21.19
20%
872
- C5 -
3SI5
-
CASC5_HUMAN
X:
[9-18]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
D
F
N
D
F
I
K
R
L
K
T
G
--------------------------------------
9
HHSearch
20.12
33%
1152
- C3 -
2LID
-
?
A:
[18-29]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
N
D
D
S
Y
F
Q
R
K
P
K
L
T
E
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
11.55
11%
659
- C5 -
3WU2
-
PSBF_THEVL
F:
[22-39]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
T
L
A
V
P
T
I
F
F
L
G
A
I
A
A
M
Q
F
I
Q
R
--------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
11.00
30%
1316
- C2 -
1J4N
1
AQP1_BOVIN
A:
[215-224]
------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
G
P
--
F
I
G
A
A
L
A
V
L
I
---
Y
D
F
I
L
A
P
R
S
S
D
L
T
D
--
R
V
K
V
W
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
10.04
30%
1458
- C1 -
2B3G
-
B:
[2-11]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
P
S
Q
A
M
D
D
L
M
L
S