@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S13A2_HUMAN: (2015-12-09 )
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP
Atome Classification :
(17 SA)
.........10........20........30........40---.........50......---..60........70..---......80........90........100.......110.......120........130.......140.......150...-----....160........170.......180---------.......190-....--...200.-......210.......220..----------......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....---...330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....--..430.......440.......450.......-------460.......470--.........480.......490.......500.......510.......520.....--..530.......540...--...--.550.......560-.......570.......580.......590-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
T
C
W
Q
A
L
W
A
Y
R
S
Y
L
I
V
F
F
V
P
I
L
LLPLPILVPSK
E
A
Y
C
A
Y
----
A
I
I
L
M
A
L
F
W
C
TE
A
L
P
L
A
---
V
T
A
L
F
P
L
I
L
F
P
M
M
GIV---
D
A
S
E
V
A
V
E
Y
LKDS
N
L
L
F
F
G
G
L
L
V
A
I
A
V
E
HW
N
L
H
K
R
I
A
L
R
V
L
L
I
VGVR
P
-
A
P
L
I
L
G
F
M
L
V
T
A
F
L
S
M
W
I
SNTAT
S
A
M
M
V
P
I
A
H
A
V
-----
L
D
Q
L
H
S
-
S
QASSNVEEGSNNP
T
F
ELQEP---------SP
Q
K
E
V
T
KLD-NGQA--LPVTSAS-SEG
R
A
H
L
S
Q
K
H
L
H
L
T
Q
C
M
-
S
L
----------
C
V
C
YSASIG
G
I
A
T
LTGTAP
N
L
V
L
QGQ
I
N
S
LFPQNG
N
V
V
N
F
A
S
W
F
S
F
A
F
P
T
M
V
I
L
L
L
L
A
W
L
W
L
Q
I
L
F
L
GFNFRKNFGI
G
E
K
M
Q
E
Q
Q
Q
A
A
Y
C
V
I
QTEHRLLG
P
M
T
---
F
A
E
K
A
I
S
I
L
F
V
I
L
V
L
L
W
FTREP
G
F
F
L
GWGNLAFPNAKGESMVSDG
T
V
A
I
F
I
G
I
I
M
F
I
IPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKM
P
W
N
I
V
L
L
LGG--
G
Y
A
LAKGSERS
G
L
S
E
W
LGNKLTPLQSVP
A
P
A
I
-------
A
I
I
L
S
L
L
V
A
T
F
----
T
E
C
TSNVA
T
T
T
I
F
L
P
I
L
A
S
M
A
Q
A
I
C
LH
P
L
Y
V
M
L
P
C
T
L
A
T
S
L
A
F
MLPVATPP
N
A
I
V
F
S--FG
D
L
K
V
L
D
M
A
RA
G
F
L
L
N
I
--
I
G
V
--
L
I
I
A
L
A
INSWG
I
P
L
-
F
SLHSFPSWAQSN
T
T
A
Q
C
L
P
S
L
ANTTTPSP-----
21
Fugue
86.16
16%
-104
- C2 -
4UNM
-
?
A:
[8-615]
---
K
Y
H
Q
Y
K
I
N
Q
P
E
Y
K
A
A
N
G
K
W
E
I
I
E
F
P
E
K
Y
R
Q
N
T
I
H
A
A
L
L
RTG
K
V
L
M
V
A
G
S
G
N
N
Q
D
N
S
D
D
KQ
Y
D
T
R
I
W
D
P
V
K
G
T
I
K
K
V
P
TPS
D
L
F
C
T
G
H
T
Q
L
A
N
G
N
L
L
I
A
G
G
---
T
K
R
Y
E
K
L
K
G
D
V
T
K
A
G
G
L
M
V
V
H
N
E
N
P
D
K
P
I
T
L
P
A
G
T
K
F
T
G
K
E
N
G
K
T
F
V
S
K
D
P
V
L
V
P
R
A
E
K
V
RND
P
G
L
G
R
I
Y
V
E
A
Q
K
S
G
S
A
Y
E
T
G
T
E
D
N
Y
R
V
Q
G
L
---------
S
G
A
D
A
R
N
T
Y
G
-
I
A
Q
K
--
L
A
L
D
K
K
D
-
F
Q
G
I
R
D
A
F
E
F
D
P
V
A
E
K
Y
I
-
K
V
DPMH
E
A
R
W
Y
P
T
L
T
T
L
G
D
-
G
K
I
L
S
V
S
G
L
D
D
I
G
Q
L
V
P
G
K
N
E
V
Y
D
P
K
T
K
A
W
T
Y
T
D
K
V
R
-
Q
F
P
T
Y
P
A
L
F
L
M
Q
N
G
--
K
I
F
Y
S
G
A
N
A
----
G
Y
G
P
D
D
V
G
R
T
P
G
V
W
D
V
E
T
N
K
F
T
K
V
P
G
M
S
DAN
M
L
E
T
A
N
T
V
L
-----
L
P
P
A
Q
D
E
K
Y
M
V
I
G
G
G
------
G
V
G
E
S
K
L
S
S
E
K
T
R
I
A
D
------
L
K
A
D
D
P
K
F
V
D
G
P
S
L
E
K
G
T
R
Y
P
Q
A
S
I
--------
L
P
D
D
S
V
L
V
S
G
G
S
Q
D
Y
R
G
R
G
D
S
N
I
L
Q
A
R
L
Y
H
P
D
T
-
N
E
F
E
R
V
A
D
P
L
V
G
R
N
Y
H
S
G
S
I
L
L
P
D
G
R
L
M
F
----
F
G
S
D
S
L
Y
A
D
K
A
N
T
K
P
--
G
K
F
E
Q
R
I
E
I
Y
T
P
P
Y
L
Y
R
D
S
R
P
D
L
S
G
G
P
Q
T
I
A
R
G
G
S
G
T
F
T
S
RA
A
S
T
V
K
K
V
R
L
I
R
P
S
A
S
T
H
V
--
T
D
V
D
Q
R
S
I
A
L
D
F
K
A
D
G
D
K
L
T
V
T
V
P
S
G
K
N
L
V
Q
S
G
W
Y
M
M
F
V
T
D
G
E
G
T
P
S
K
A
E
W
V
R
V
P
1
PsiBlast_PDB
51.00
38%
-73
- C3 -
4F35
-
?
D:
[295-440]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
H
W
K
E
I
Q
K
T
A
D
W
G
V
L
L
L
F
G
G
--
G
L
C
L
S
N
V
L
K
Q
T
G
T
S
V
F
L
A
N
A
L
S
D
M
V
S
H
M
G
I
F
V
-------
V
I
---
L
V
V
A
T
F
V
VFL
T
E
F
A
S
N
T
A
S
A
A
L
L
I
P
V
F
A
T
V
A
E
A
F
G
M
S
P
V
L
L
S
V
L
I
A
V
A
A
S
C
A
F
M
L
P
V
A
T
P
P
N
A
I
V
F
A
--
S
G
H
I
K
Q
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
G
L
--
L
T
A
I
A
M
L
F
W
Q
----------------------------------------
2
PsiBlast_PDB
44.94
29%
114
* C4 *
4AK1
-
?
A:
[462-529]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
T
A
T
D
A
-----
K
D
G
L
S
S
-
L
K
W
E
V
E
L
K
H
N
P
N
N
T
K
A
T
I
N
E
S
---------
T
G
Q
I
T
I
T
G
L
K
-
Q
G
Q
C
G
M
V
M
V
T
A
T
A
-
G
E
G
K
T
A
V
S
V
K
Q
P
V
F
F
H
F
S
-
M
I
----------
S
D
S
N
V
Q
L
E
Y
T
P
F
V
F
Q
V
N
P
A
R
G
G
E
S
I
A
P
S
L
G
A
G
I
D
K
S
T
F
R
L
D
Y
R
R
D
F
F
Y
Y
N
I
A
G
P
D
S
H
I
S
G
A
L
A
Q
K
V
D
N
F
L
S
E
M
W
N
S
Y
D
A
T
A
G
T
S
R
K
P
M
S
Y
F
E
N
T
T
N
L
S
K
A
L
G
Y
---
I
D
Q
T
D
F
K
V
H
I
N
P
N
L
W
R
N
K
D
G
Y
A
N
G
A
M
I
G
Q
I
T
Y
D
V
T
G
K
D
P
Q
A
A
T
S
G
A
R
V
S
P
I
F
I
W
F
D
T
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
36.93
27%
328
* C3 *
1SVF
-
?
B:
[1-38]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
S
I
D
P
L
D
-
I
S
Q
N
--
L
A
A
V
N
K
S
L
S
D
A
L
Q
H
L
A
Q
S
D
T
Y
L
S
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
35.81
29%
105
- C4 -
4AK2
1
?
A:
[42-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
T
A
T
D
A
-----
K
D
G
L
S
S
-
L
K
W
E
V
E
L
K
H
N
P
N
N
T
K
A
T
I
N
E
S
---------
T
G
Q
I
T
I
T
G
L
K
-
Q
G
Q
C
G
M
V
M
V
T
A
T
A
-
G
E
G
K
T
A
V
S
V
K
Q
P
V
F
F
H
F
S
-
M
I
----------
S
D
S
N
V
Q
L
E
Y
T
P
F
V
F
Q
V
N
P
A
R
G
G
E
S
I
A
P
S
L
G
A
G
I
D
K
S
T
F
R
L
D
Y
R
R
D
F
F
Y
Y
N
I
A
G
P
D
S
H
I
S
G
A
L
A
Q
K
V
D
N
F
L
S
E
M
W
N
S
Y
D
A
T
A
G
T
S
R
K
P
M
S
Y
F
E
N
T
T
N
L
S
K
A
L
G
Y
---
I
D
Q
T
D
F
K
V
H
I
N
P
N
L
W
R
N
K
D
G
Y
A
N
G
A
M
I
G
Q
I
T
Y
D
V
T
G
K
D
P
Q
A
A
T
S
G
A
R
V
S
P
I
F
I
W
F
D
T
K
F
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
35.41
29%
661
- C3 -
3S8F
4
COXA_THET8
C:
[18-31]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
V
F
W
L
G
V
Y
A
V
F
F
A
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
33.03
15%
142
- C3 -
1F02
-
?
T:
[271-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
D
Q
A
A
N
A
A
E
S
A
T
K
D
Q
L
T
Q
E
A
F
K
---------
N
P
E
N
Q
K
V
N
I
D
A
N
G
N
A
--
I
P
S
G
E
L
K
-
D
D
I
V
E
Q
I
A
Q
Q
A
K
E
A
G
E
V
A
-
R
Q
----------
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
31.42
17%
187
- C3 -
2X43
-
?
S:
[1-67]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
Q
E
T
R
-
D
Q
M
K
N
A
A
A
E
A
K
D
N
V
H
D
K
I
Q
E
L
KDDVGNKAA
E
V
R
D
A
V
S
S
T
V
-
E
S
I
K
--
D
K
L
S
G
G
S
-
S
S
R
A
S
S
Y
T
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
30.69
12%
268
- C3 -
2KK9
-
A:
[1-55]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
-
R
R
D
L
D
A
S
R
E
A
K
K
Q
L
E
A
E
Q
Q
K
L
---------
E
E
Q
N
K
I
S
E
A
S
-
R
K
G
L
--
R
R
D
L
D
A
S
-
R
E
A
K
K
Q
V
E
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
30.57
32%
482
- C3 -
1XKM
2
?
B:
[1-25]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
V
S
G
L
-
I
E
A
R
K
Y
L
E
Q
L
H
R
K
L
K
N
C
K
-
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
28.38
22%
222
- C3 -
2LX0
-
?
A:
[6-28]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
I
A
G
L
V
A
L
L
T
F
L
A
F
G
F
W
L
F
K
Y
L
Q
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
24.75
17%
262
- C3 -
4A54
-
DCP2_SCHPO
B:
[240-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
A
T
T
K
E
K
N
I
S
V
D
V
D
A
D
A
-----
S
S
Q
L
L
S
-
L
L
K
S
S
T
A
P
S
D
L
A
T
P
Q
P
S
T
F
P
Q
---------
P
P
V
E
S
H
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
22.98
29%
542
- C4 -
1PG1
1
?
?:
[1-18]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
G
R
L
C
Y
C
R
R
R
F
----------
C
V
C
V
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
20.65
29%
3251
- C1 -
3UKX
-
?
C:
[15-21]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
D
D
D
D
--
P
P
K
K
R
R
R
-
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
18.87
12%
290
- C3 -
2WWB
-
SC61G_CANFA
B:
[34-66]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
I
A
M
A
T
-
A
I
----------
G
F
A
I
M
G
F
I
G
F
F
V
K
L
I
H
I
P
I
N
N
I
I
V
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
18.83
19%
511
- C3 -
2L8S
-
A:
[24-44]
-------------------------------------------------------------------------------------------------------
M
L
L
I
L
A
L
W
K
I
G
F
F
K
R
P
L
K
K
K
M
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
15.21
25%
1075
- C3 -
1LDF
-
GLPF_ECOLI
A:
[237-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
P
I
V
G
A
I
-----
V
G
A
F
A
Y
-
R
K
L
I
G
R
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------