@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S18B1_HUMAN: (2015-12-09 )
MEALGDLEGPRAPGGDDPAGSAGETPGWLSREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLLPNET
Atome Classification :
(20 SA)
------.........10........20.....-----------...30........40........50........60.-----.-.-.....---70.----.......80........90.----......---------.100------....---...110--........120.-......130.......140----.......150.......--160..--------......-170......-.180.......190------------------------.........200.....--------..210-.....-------.-------.220-------.------.-------------.------..------..-----230....--------------...240.......250....----...260-----...---.---...270..---.....-280..--......290------.......300........-.310...-....320..----------.....330-----......----...340.......350----.......-------360....--...370.......-380..--...----..-390......-.---------400--.......-----..410..-------.....420..-.....430......-----------.440.......450....-----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MEALGDLEGPRAPGGDDPAGSAGETP-----------GWLS
R
E
Q
V
F
V
L
I
S
AASV
N
L
G
S
M
M
C
Y
S
I
LGPFF
P
K
E
A
-----E-K-KGASN---
T
I
I
----
G
M
I
F
G
C
F
A
L
F
E
L
L
A
S
L
V
FG
N
----
Y
L
V
H
IG---------
A
K
F
M
------
F
V
A
G
---
M
FVSG---
G
V
T
I
L
F
G
V
L
DRV-PDG
P
V
F
I
A
M
C
F
L
V
R
V
M
D
A
V
----
S
F
A
A
A
M
TA
S
S
S
I
L
A
K
AF--PN-
N
V
--------
A
T
V
L
G
S
-
L
E
T
FSGL
G
L
-
I
LGPPV
G
G
F
L
Y
Q
--------------------------SFGYE
V
P
F
I
V
L
G
C
V
V
L
L
--------
M
VPL
N
-
M
Y
I
LP-------N-------YESD-------P------G-------------E------
H
S
------
F
W
-----
K
L
I
ALPK--------------
V
G
L
I
A
F
V
I
N
S
L
S
S
C
F
G
FLDP----
T
L
S
L
F
V
-----
L
E
K---F---NL
P
A
G
Y
V
G
---
L
V
F
L
G
-
M
-
A
L
S
--
Y
A
I
SS
P
L
F
G
------
L
LSDKRP
P
--
L
R
K
W
L
L
V
F
-
G
N
L
I
T
A
G
-
C
Y
M
LLGPV
P
----------
I
L
H
I
K
S
-------
Q
L
W
L
L
V
----
L
I
L
V
V
S
G
L
S
AGMSIIP----T
F
P
E
I
L
S
-------
C
A
HEN
G
F
--
E
E
G
L
S
T
L
G
L
V
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L
-
F
S
A
M
W
--
S
I
G
----
A
F
-MGP
T
L
G
G
F
L
-
Y
---------
E
----
K
I
G
F
E
W
A
-----
A
A
I
Q
G
L
W
-------
A
L
I
S
G
L
A
M
G
L
-
F
Y
L
L
E
Y
S
R
R
KRSKS-----------QNILSTEEE
R
T
TLLPNET-----------------------------------------------------------------
24
Fugue
86.79
20%
-131
- C2 -
3WDO
-
?
A:
[1-453]
--------------------------
D
Y
K
M
T
P
-----------
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
-
R
M
L
G
M
F
M
V
L
P
V
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T
T
Y
---
G
M
-----
A
-
L
-
Q
G
A
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---
A
L
I
----
G
I
A
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Y
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----
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---
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A
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A
---
A
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--------
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G
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---
A
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----
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L
G
P
I
I
T
H
--------------------------
K
L
G
L
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A
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F
W
M
I
A
I
L
A
T
T
--------
G
I
A
L
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W
V
V
P
-------
N
S
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T
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N
R
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-------
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------
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-------------
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------
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------
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-----
K
V
L
A
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P
R
--------------
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L
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L
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----
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-----
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---
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---
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---
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Y
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A
T
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M
-
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A
--
F
G
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V
V
P
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A
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K
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K
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--
K
Q
V
F
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C
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-
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V
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-----------------
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-------
Q
F
W
Q
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----
V
G
V
Q
L
F
F
V
A
F
N
L
-
M
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A
----
L
L
P
S
L
I
S
-------
K
E
S
P
A
G
Y
--------
K
G
T
A
M
G
V
-
Y
S
T
S
Q
--
F
L
G
----
V
A
-
I
G
G
S
L
G
G
W
I
-
D
---------
G
M
FD
G
Q
G
V
F
L
A
G
-----
A
M
L
A
A
V
W
-------
L
A
V
A
S
T
M
K
E
P
-
P
Y
V
---
S
S
L
R
I
E
I
P
-----------
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
VK
E
V
L
I
AEEEH
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL------------------------------
29
Fugue
83.45
17%
-116
- C1 -
4Y9J
4
?
A:
[1-592]
-----T
I
T
A
R
H
T
Q
Y
S
H
A
K
T
G
G
F
S
Q
T
G
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L
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L
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A
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---
K
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----
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K
L
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C
-
N
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W
H
K
L
K
Q
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C
A
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----
G
V
I
S
I
G
Y
EDSVD
P
F
V
R
R
I
H
------
Q
V
A
K
---
L
F
L
F
S
---
P
S
A
G
L
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P
M
A
M
-
T
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A
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K
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----
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A
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P
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A
W
--
T
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-
G
Q
W
MTEKKGG
S
D
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A
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G
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D
T
Y
A
V
Q
I
D
-
K
D
T
Y
R
L
H
G
Y
K
W
F
--------------------------
S
S
A
V
D
A
D
V
A
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T
L
A
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D
SDG
N
A
L
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G
S
R
G
L
S
-
L
F
L
L
K
---------------
I
R
D
E
-------
S
------
G
-------------
N
------
L
N
------
G
I
-----
Q
M
V
R
L
K
N
KLGTKQ
L
P
T
A
E
L
L
L
D
G
A
I
A
E
R
I
G
D
Q
G
R
G
V
A
G
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S
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----
M
L
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I
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-----
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---
A
---
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A
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L
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----
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G
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-
M
L
L
L
F
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A
A
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----------
L
L
G
L
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D
V
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A
M
M
L
R
----
L
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P
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L
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L
Y
A
G
K
Q
A
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P
----
M
V
S
E
G
I
E
-------
C
F
G
G
Q
G
Y
ME
D
T
G
L
P
T
L
L
R
D
A
Q
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--
T
P
I
W
EG
T
T
N
----
V
L
-
S
L
D
V
L
R
V
F
S
G
K
---------
E
----
N
I
L
L
A
F
G
-----
K
R
V
E
Q
L
L
G
NTKTED
E
K
L
K
K
S
K
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A
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-
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A
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K
Q
L
Q
K
L
L
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K
A
-----------
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A
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H
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DSSVAN
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CEQPLIDLRWEWFA
S
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K
A
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R
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F
DNFT
26
Fugue
82.35
19%
-131
- C2 -
5D2E
3
?
A:
[5-510]
------
T
M
Q
I
E
Q
I
V
K
K
V
K
E
C
S
L
T
P
E
E
G
L
E
L
I
K
-----------
S
-
L
G
K
T
H
L
Y
E
M
V
W
D
R
H
E
F
K
G
S
--------
K
K
F
P
H
T
K
-----
E
-
P
-----------
I
----
L
F
F
C
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D
D
S
M
Y
T
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M
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R
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Y
E
A
P
F
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Y
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T
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---------
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R
F
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DCRNG
R
F
T
M
N
---
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T
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G
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---
D
Y
D
A
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H
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--
N
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--------
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---
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K
A
E
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L
Y
L
--------------------------
Y
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N
A
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G
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Q
P
I
Y
N
A
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--------
F
L
K
T
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Q
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-------
F
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C
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-------
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------
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-----
F
D
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--------------
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---
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----
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A
F
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A
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W
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A
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Q
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D
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A
F
-
A
N
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C
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F
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-
Q
Y
R
S
M
K
GRP
G
K
----
T
L
S
I
N
W
P
LWDAG
A
L
R
H
A
G
L
-------
E
L
L
S
--
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-
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A
A
F
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D
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A
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-----------
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A
V
I
S
G
D
K
D
R
I
S
E
L
L
S
-------------------------------------------------------------------
25
Fugue
76.08
19%
-120
- C4 -
4R33
4
?
A:
[35-418]
----------
G
D
F
V
L
P
E
L
E
D
V
R
A
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A
A
T
V
D
T
R
A
-----------
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L
A
L
A
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A
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V
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A
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E
-
A
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R
C
G
A
-------------------------------------------------------------------------------------
R
R
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----
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--------
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-
L
Y
H
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G
---------
V
R
G
V
G
F
L
--------------------------
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A
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--------
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W
A
I
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-
T
A
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D
L
-------
G
-------
F
E
---------------------------------------------------------------------------
R
V
Y
F
N
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S
M
E
------------
Q
D
E
I
D
V
-----
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G
E
---
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---
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----------
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L
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D
D
L
-------
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A
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L
V
S
----
L
V
A
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G
D
H
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A
T
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---------
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L
S
-------
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S
V
V
----
A
F
-
T
C
P
E
Q
R
L
V
L
-
T
---------
T
----
R
E
P
Q
E
F
Q
-----
D
V
A
L
G
L
A
-------
G
V
I
S
P
G
S
P
D
V
A
P
Y
R
A
G
C
E
A
R
N
D
E
K
S
SQFLVADLRR
P
R
H
I
L
G
R
I
E
A
S
G
T
P
V
D
H
F
V
NPAGEASR---------------------------------------------------------
22
Fugue
74.59
9%
-135
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
-----------
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
---------
V
-
E
-
Q
G
F
S
R
---
G
D
L
----
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
----
V
S
D
R
S
N
---------
P
R
V
F
------
L
P
A
G
---
L
I
L
A
A
---
A
V
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
--
R
G
-
G
I
--------
V
S
V
W
N
C
-
A
H
N
V
G
G
G
---
I
P
P
L
L
F
L
L
G
M
A
W
--------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
--------
V
A
L
F
A
-
F
A
M
M
R
-------
D
-------
T
P
Q
S
-------
C
------
G
LPPIEEYKNDTAK
Q
------
I
F
------
M
Q
-----
Y
V
L
P
N
K
L
--------------
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
----
W
S
P
T
Y
L
-----
K
E
V
---
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
-
Y
-
E
Y
A
--
G
I
P
G
T
L
L
C
G
------
W
M
S
D
K
V
F
R
--
G
N
R
G
A
T
G
V
-
F
F
M
T
L
V
T
-
I
A
T
I
V
Y
W
M
N
----------
P
A
G
N
P
T
-------
V
D
M
I
C
M
----
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
----
H
A
L
E
L
A
P
-------
K
K
A
A
G
T
A
--
A
G
F
T
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
--
I
V
G
----
Y
T
-
V
D
F
F
-------------------------
G
W
D
-----
G
G
F
M
V
M
I
-------
G
G
S
I
L
A
V
I
L
L
-
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
-----------
L
Q
E
L
V
P
-----------------------------------------------------------------------------
21
Fugue
73.90
14%
-115
* C2 *
1PV6
-
LACY_ECOLI
A:
[1-417]
------
M
Y
Y
L
K
-----------------------------------
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
----------
H
I
S
K
---
S
D
T
----
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
----
L
S
D
K
L
G
---------
L
R
K
Y
------
L
L
W
I
---
I
T
G
M
L
---
V
M
F
A
P
F
F
I
F
I
F
G
-
P
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
----
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
--
S
R
-
R
S
--------
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
--------------------------
I
-
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
--------
L
A
V
L
L
-
F
F
A
K
T
-------
D
-------
A
P
S
S
-------
A
------
T
VANAVGANHSAFS
L
------
K
L
------
A
L
-----
E
L
F
R
Q
P
K
--------------
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
----
Q
F
A
N
F
F
-----
T
S
F
---
F
AT
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
-
G
-
E
L
L
--
N
A
S
I
M
F
F
A
P
------
L
I
I
N
R
I
G
----
G
K
N
A
L
L
L
-
A
G
T
I
M
S
V
-
R
I
I
G
S
S
F
A
----------------
T
-------
S
A
L
E
V
V
----
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
----
C
F
K
Y
I
T
S
-------
Q
F
E
V
R
F
S
--
A
T
I
Y
L
V
C
F
-------
C
F
F
K
--
Q
L
A
----
M
I
-
F
M
S
V
L
A
G
N
M
-
Y
---------
E
----
S
I
G
-----------
F
Q
G
A
Y
-------
L
V
L
G
L
V
A
L
G
F
-
T
L
I
S
V
F
T
L
S
G
P
G
P
L
-----------
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------------------------------------
13
HHSearch
73.34
18%
-138
- C2 -
3WDO
-
?
A:
[27-374]
--------------------------------------------------------------------
F
M
V
L
P
V
L
T
T
Y
G
-----
M
A
L
-
Q
G
A
S
E
---
A
L
I
----
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
----
L
S
D
R
I
G
---------
R
K
P
L
------
I
V
G
G
---
L
A
V
F
A
---
A
G
S
V
I
A
A
L
S
D
S
I
--------
W
G
I
I
L
G
R
A
L
Q
G
S
----
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
--
R
E
Q
N
R
--------
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
--------
G
I
A
L
T
-
I
W
V
V
P
-------
N
-------
S
S
T
H
-------
V
L
N
R
---
E
SGMV---------
K
------
G
S
------
F
S
-----
K
V
L
A
E
P
R
--------------
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
----
A
L
P
G
Q
L
-----
A
D
----
A
---
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
-
I
-
A
F
G
--
S
V
V
P
F
I
I
Y
A
------
E
V
K
R
K
M
K
----
Q
V
F
--
V
F
-
C
V
G
L
I
V
V
-
A
E
I
V
L
W
N
---------------
A
Q
T
-------
Q
F
W
Q
L
V
----
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
-
A
----
L
L
P
S
L
I
S
-------
K
E
----
S
--
P
--
A
G
Y
K
G
T
A
M
G
V
-
Y
S
T
S
Q
--
F
L
G
----
V
A
-
I
G
G
S
L
G
G
W
I
-
D
---------
G
----
M
F
D
G
Q
G
V
-----
F
L
A
G
A
M
L
-------
A
A
V
W
L
A
V
A
S
T
-
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
-----------
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
-----------------------------------------------------------------
1
PsiBlast_PDB
72.35
21%
-141
- C2 -
3WDO
-
?
A:
[41-359]
----------------------------------------------------------------------------------------
Q
G
A
S
E
---
A
L
I
----
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
----
L
S
D
R
I
G
---------
R
K
P
L
------
I
V
G
G
---
L
A
V
F
A
---
A
G
S
V
I
A
A
L
S
D
S
I
-
W
G
-------
I
I
L
G
R
A
L
Q
G
S
G
---
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
----
E
Q
-
N
R
--------
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
--------
G
I
A
L
T
-
I
W
V
V
P
NS
S
T
H
V
L
N
-------
R
E
S
G
-------
M
------
V
-------------
K
------
G
S
------
F
S
-----
K
V
L
A
E
P
R
--------------
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
----------
M
S
T
F
V
A
L
P
G
Q
L
A
D
---
A
---
G
F
P
A
A
E
H
W
---
K
V
Y
L
A
T
M
-
L
I
A
--
F
G
S
V
V
P
F
I
I
------
Y
A
E
V
K
R
K
M
--
K
Q
V
F
V
F
C
V
-
G
L
I
V
V
A
--------
E
I
V
----------
L
W
N
A
Q
T
-------
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
---------
L
P
S
L
I
S
-------
K
E
S
P
A
G
Y
--
K
------
G
T
A
M
G
V
-
Y
S
T
S
Q
--
F
L
G
----
V
A
-
I
G
G
S
L
G
G
W
I
-
D
---------
G
----
M
F
D
G
Q
G
V
-----
F
L
A
G
A
M
L
-------
A
A
V
W
L
A
V
A
S
T
-
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
-----------
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
-----------------------------------------------------------------
14
HHSearch
71.78
18%
-118
- C2 -
2CFQ
-
LACY_ECOLI
A:
[24-389]
--------------------------------------------------------------------
G
A
Y
F
P
F
F
P
I
W
L
-----
H
-
D
I
N
H
I
S
K
---
S
D
T
----
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
----
L
S
D
K
L
G
---------
L
R
K
Y
------
L
L
W
I
I
T
G
M
L
V
M
F
---
A
P
F
F
I
F
I
F
G
P
L
L
---
Q
Y
N
----
I
L
V
G
S
I
V
G
G
I
YLGF
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
---
R
-
R
S
--------
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
--------
L
A
V
L
L
-
F
F
A
K
T
-------
D
-------
A
P
S
S
-------
A
TVANAV
G
A------------
N
H
S
A
F
S
L
K
L
------
A
L
-----
E
L
F
R
Q
P
K
--------------
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
----
Q
F
A
N
F
F
-----
T
S
F
FAT
G
---
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
-
G
-
E
L
L
--
N
A
S
I
M
F
F
A
P
------
L
I
I
N
R
I
G
G
--
K
-
N
A
-
L
L
L
-
A
G
T
I
M
S
V
-
R
I
I
G
S
S
F
----------------
A
T
-------
S
A
L
E
V
V
----
I
L
K
T
L
H
M
F
E
V
P
F
L
L
-
V
----
G
C
F
K
Y
I
T
-------
S
----
Q
F
--
E
--
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
--
Q
L
A
----
M
I
-
F
M
S
V
L
A
G
N
M
-
Y
---------
E
----
S
I
G
F
Q
G
A
-----
Y
L
V
L
G
L
V
-------
A
L
G
F
T
L
I
S
V
F
-
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
-----------
V
N
E
V
A
------------------------------------------------------------------------------
30
Fugue
71.09
17%
-107
- C4 -
4K7J
3
?
A:
[26-375]
----------
G
L
L
T
D
Y
---------
G
N
A
S
A
S
P
------------
W
M
K
K
L
Q
S
V
A
Q
G
S
G
E
T
F
R
I
L
Q
I
G
D
S
H
T
A
G
D
F
F
T
D
S
L
-----
R
-
K
-
R
L
Q
K
T
WGD
G
G
I
----
G
W
V
Y
P
A
N
V
K
G
Q
R
M
A
A
V
R
H
N
G
----
N
W
Q
S
L
T
---------
S
R
N
N
--------
T
G
---
D
F
P
L
G
---
G
I
L
A
H
T
G
------
S
G
G
S
M
T
L
T
A
--------------
S
D
G
I
A
S
K
Q
R
V
S
L
F
A
K
P
L
L-
A
E
-
Q
T
--------
L
T
V
N
G
N
-
T
V
S
A
N
G
G
G
------------
W
Q
--------------------------
V
L
D
T
G
A
A
---
L
P
L
T
I
H
T
--------
E
M
P
W
D
-
I
G
F
I
--------
N
-------
I
E
N
P
-------
A
------
G
-------------
G
-----------------------
I
T
V
S
A
--------------
M
G
I
N
G
A
Q
L
T
Q
W
S
K
W
R
A
D
-------------------
R
M
---
N
---
D
L
A
Q
T
G
A
D
---
L
V
I
L
S
-
Y
-
G
T
N
--
E
A
F
N
N
N
I
--------
D
I
A
D
T
E
Q
K
--
W
L
D
T
V
R
Q
I
-
R
D
S
L
P
A
A
-
G
I
L
I
I
G
A
P
E
----------
S
L
K
-------------------------
N
T
L
G
V
C
G
T
R
P
V
----
R
L
T
E
V
Q
Q
-------
M
Q
R
R
V
A
R
--
Q
G
Q
------------
T
M
F
W
--
S
W
Q
----
N
A
-
M
G
G
I
------------------------
C
S
M
K
-----
N
W
L
N
Q
G
W
-------
A
A
K
D
G
V
H
F
S
--------
A
K
G
Y
R
R
A
A
-----------
E
M
L
A
D
S
L
E
E
L
V
R
S
A
---------------------------------------------------------------------
10
HHSearch
69.63
8%
-133
- C2 -
1PW4
-
GLPT_ECOLI
A:
[25-426]
----------------------------------------------
R
L
R
W
Q
-
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
------
V
-
E
-
Q
G
F
S
R
---
G
D
L
----
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
----
V
S
D
R
S
N
---------
P
R
V
F
------
L
P
A
G
---
L
I
L
A
A
---
A
V
M
L
F
M
G
F
V
P
W
A
-
T
--
S
S
I
-
A
V
M
F
V
L
L
F
L
C
G
W
----
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
--
S
Q
K
E
R
--------
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
--------
V
A
L
F
A
-
F
A
M
M
R
-------
D
-------
T
P
Q
S
CGLPPIE
E
------
Y
KND------------------
T
------
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
--------------
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
----
W
S
P
T
Y
L
-----
K
E
V
---
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
-
Y
-
E
Y
A
--
G
I
P
G
T
L
L
C
G
------
W
M
S
D
K
V
F
R
--
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
-
A
T
I
V
Y
W
M
--------------
N
P
A
G
-------
N
P
T
V
D
M
----
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
-
M
----
L
I
G
L
H
A
L
-------
E
L
----
A
--
P
--
K
K
A
A
G
T
A
A
G
F
-
T
G
L
F
G
--
Y
L
G
----
G
S
V
A
A
S
A
I
V
G
Y
T
-
V
---------
D
----
F
F
G
W
D
G
G
-----
F
M
V
M
I
G
G
-------
S
I
L
A
V
I
L
L
I
V
-
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
-----------
E
L
V
P
-------------------------------------------------------------------------------
23
Fugue
69.40
12%
-118
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
-----
R
-
D
-
L
N
V
R
E
---
G
A
V
----
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
----
I
S
D
R
V
G
---------
R
R
P
V
------
I
L
V
G
---
M
S
I
F
M
---
L
A
T
L
V
A
V
T
T
S
S
L
-
T
V
-------
L
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
-
R
T
-
Q
L
--------
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
--------
V
T
F
S
M
-
A
R
W
M
P
-------
E
-------
T
R
P
V
-------
D
------
A
-------------
P
------
R
T
RLLTSY
K
T
-----
L
F
G
N
S
G
F
--------------
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
----
S
-
G
V
L
M
-----
G
A
V
---
L
---
G
L
S
S
M
T
V
S
---
I
L
F
I
L
-
P
-
I
P
A
--
A
F
F
G
A
W
F
A
G
------
R
P
N
K
R
F
S
T
--
L
M
W
Q
S
V
I
C
-
C
L
L
A
G
L
------
L
M
W
I
P
----------
D
W
F
G
V
M
-------
N
V
W
T
L
L
----
V
P
A
A
L
F
F
F
G
A
G
M
L
-----------------------
F
P
L
A
T
--
S
G
A
M
E
P
F
P
F
L
A
G
T
-
A
G
A
L
V
--
G
G
L
----
Q
N
-
I
G
S
G
V
L
A
S
L
-
S
---------
A
----
M
L
P
Q
T
G
Q
-----
G
S
L
G
L
L
M
-------
T
L
M
G
L
L
I
V
L
C
-
W
L
P
L
--------------------------------------------------------------------------------------------------------
11
HHSearch
67.75
16%
-132
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[22-325]
-----------------------------------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
-----
Q
-
A
-
F
T
L
T
N
---
F
Q
A
----
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
----
L
M
K
K
L
S
---------
Y
K
A
G
------
I
I
T
G
---
L
F
L
Y
A
---
L
G
A
A
L
F
W
P
A
A
E
I
----
M
N
Y
-
T
L
F
L
V
G
L
F
I
I
A
A
----
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
--
P
E
S
S
G
--------
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
--------
V
A
L
L
I
M
L
T
K
F
P
-------
A
-------
L
Q
S
D
-------
N
------
H
SDAK---------
Q
GS
F
S
--
A
S
------
L
S
-----
R
L
A
R
I
R
H
--------------
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
----
Y
L
I
R
Y
A
-----
V
E
E
I--
P
---
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
-
T
-
M
V
C
--
F
F
I
G
R
F
T
G
T
------
W
L
I
S
R
F
A
P
--
H
K
V
L
A
A
Y
A
-
L
I
A
M
A
L
C
-
L
I
S
A
F
A
G
G
H
----------
V
G
L
I
A
L
-------
T
L
C
S
A
F
----
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
----
G
Q
D
T
K
Y
G
-------
S
S
F
I
V
M
T
--
I
I
G
G
G
I
V
T
P
V
M
G
F
-
V
S
D
A
A
--
G
N
I
----
P
T
-
A
E
L
I
P
A
L
C
F
-
A
---------
V
----
I
F
I
F
A
R
F
-----
R
S
Q
T
---------------------------------------------------------------------------------------------------------------------------------
27
Fugue
65.13
18%
-133
* C4 *
4N5H
3
?
X:
[1-315]
MADEEA
M
L
A
K
V
Q
A
S
W
A
Q
T
A
A
R
D
K
A
R
Y
A
D
E
R
V
P
-----------
E
D
V
H
W
E
T
E
Y
R
Y
E
Q
S
A
D
P
Q
-------
Q
T
L
N
L
Y
Y
P
A
K
R
-----
R
-
N
-
A
T
M
P
T
---
V
I
D
IHGG
G
W
F
Y
G
D
R
N
L
-----
N
R
N
Y
C
R
----
Y
L
A
S
Q
G
---------
Y
A
V
M
------
G
M
G
--------------------
Y
R
L
L
-
P
D
V
D
L
R
G
Q
I
Q
D
I
F
A
S
L
R
W
L
----
S
H
F
G
--------
P
Q
R
G
F
--
D
L
-
D
H
--------
V
L
L
T
G
D
-
S
A
G
G
H
L
A
S
L
-
V
A
C
I
Q
Q
S
A
E
L
Q
E
--------------------------
L
F
G
V
S
R
V
N
F
N
F
T
L
V
A
L
V
--------
C
P
V
A
E
-
P
S
K
L
P
-------
E
-------
A
A
G
D
-------
M
------
S
-------------
D
--------------------------------------------
M
A
A
F
Y
L
D
K
L
S
G
G
D
Q
A
L
V
D
----
H
L
N
F
S
Q
-----
V
V
K
G--
L
---
D
L
P
P
-------
F
M
L
I
G
-
G
-
Q
N
D
SF
Y
L
Q
S
Q
A
L
L
K
------
V
F
D
A
N
H
-----------------------------------------
V
T
Y
T
T
-------
K
L
W
-------------
P
A
S
A
G
----
P
----
H
L
K
H
V
F
N
-------
V
Q
H
-----------------------------------------------------------------
W
E
W
P
-----
E
S
I
E
T
N
L
-------
E
M
L
R
T
F
D
--------
A
L
S
K
Q
Q
D
Q
A
E
-----------
E
N
E
--------------------------------------------------------------------------------
12
HHSearch
64.76
13%
-113
- C2 -
2GFP
-
EMRD_ECOLI
A:
[24-361]
-------------------------------------------------------------------
Q
T
I
Y
I
P
A
I
A
D
M
A
-----
R
-
D
-
L
N
V
R
E
---
G
A
V
----
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
----
I
S
D
R
V
G
---------
R
R
P
V
------
I
L
V
G
---
M
S
I
F
M
---
L
A
T
L
V
A
V
T
T
S
S
L
--------
T
V
L
I
A
A
S
A
M
Q
G
M
----
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
--
E
R
T
Q
L
--------
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
--------
V
T
F
S
M
-
A
R
W
M
P
-------
E
-------
T
R
P
V
-------
D
------
A
P
R
T
RL--------
L
------
T
S
------
Y
K
-----
T
L
F
G
N
S
G
--------------
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
----
C
S
G
V
L
M
-----
G
A
V
---
L
---
G
L
S
S
M
T
V
S
---
I
L
F
I
L
-
P
-
I
P
A
--
A
F
F
G
A
W
F
A
G
------
R
P
N
K
R
F
S
T
--
L
-
M
W
Q
S
V
I
-
C
C
L
L
A
G
--
L
L
M
W
I
P
D
-------------
W
F
G
V
M
-------
N
V
W
T
L
L
----
V
P
A
A
L
F
F
F
G
A
G
M
L
F
-
P
----
L
A
T
S
G
A
M
-------
E
P
-------
F
--
P
F
L
A
G
T
A
G
A
L
-
V
G
G
L
Q
--
N
I
G
----
S
G
-
V
L
A
S
L
S
A
M
L
-
P
---------
Q
----
T
G
Q
G
S
L
G
-----
L
L
M
T
L
M
G
-------
L
L
I
V
L
C
W
L
P
L
-------------------------------------------------------------------------------------------------------------
17
HHSearch
50.04
20%
-130
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[46-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
----
L
L
P
Q
-
F
-----
Q
Q
A
---
F
---
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
-
F
-
Y
F
G
--
Y
F
I
I
P
I
P
A
G
------
I
L
M
K
K
L
S
Y
--
K
-
A
-
G
I
I
T
-
G
L
F
L
Y
A
L
-
G
A
A
L
F
W
P
A
A
-------------
E
I
M
-------
N
Y
T
L
F
L
----
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
----
A
N
P
-
F
V
T
-------
V
L
----
G
--
P
--
E
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
--
S
F
G
----
A
I
-
I
A
V
V
F
G
Q
S
L
-
I
---------
L
----
S
N
V
P
H
Q
S
-----
Q
D
V
L
D
K
M
-------
S
P
E
Q
L
S
A
Y
K
H
-
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
-----------
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
-----------------------------------------------------------------
16
HHSearch
49.97
18%
-115
- C2 -
3WDO
-
?
A:
[29-174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
P
----
V
L
T
T
Y
G
-----
M
A
L
---
Q
---
G
A
S
E
A
L
I
G
---
I
A
I
G
I
-
Y
-
G
L
T
--
Q
A
V
F
Q
I
P
F
G
------
L
L
S
D
R
I
G
R
--
K
-
P
-
L
I
V
G
-
G
L
A
V
F
A
A
-
G
S
V
I
A
A
L
----------------
S
D
-------
S
I
W
G
I
I
----
L
G
R
A
L
Q
G
S
G
A
I
--
A
-
A
----
A
V
M
A
L
L
S
-------
D
L
----
T
--
R
--
E
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
--
G
I
T
----
F
A
-
I
A
M
V
L
G
P
I
I
-
T
---------
H
----
K
L
G
L
H
A
L
-----
F
W
M
I
A
I
L
-------
A
T
T
G
I
A
L
T
I
W
-
V
V
P
N
S
S
T
H
V
L
N
R
E
S
-----------
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
-----------------------------------------------------------------
18
HHSearch
47.33
14%
-120
- C2 -
1PW4
-
GLPT_ECOLI
A:
[274-427]
------------------------------------------------------------------------
D
W
S
P
T
Y
L
-----
K
-
E
V
K
H
F
A
L
---
D
K
S
----
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
----
M
S
D
K
V
F
---------
R
G
N
R
------
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
--
G
N
P
T
V
----
D
M
I
C
M
I
V
I
G
F
----
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
--
P
K
K
A
A
--------
G
T
A
A
G
F
-
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
--------------------------
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
--------
A
V
I
L
L
-
I
V
V
M
I
-------
G
-------
E
K
R
R
-------
H
------
E
-------------
Q
------
L
L
------
Q
E
-----
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
45.01
18%
-96
- C2 -
2GFP
-
EMRD_ECOLI
A:
[29-170]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
A
I
A
D
-
M
-----
A
R
D
---
L
---
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
-
Y
-
L
L
T
--
Y
G
V
S
Q
L
F
Y
G
------
P
I
S
D
R
V
G
R
--
R
-
P
V
-
I
L
V
-
G
M
S
I
F
M
L
-
A
T
L
V
A
V
T
----------------
T
S
-------
S
L
T
V
L
I
----
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
-
V
----
M
A
R
T
L
P
R
-------
D
L
----
Y
--
E
--
R
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
--
L
V
S
----
P
L
-
L
A
P
L
I
G
G
L
L
-
D
---------
T
----
M
W
N
W
R
A
C
-----
Y
L
F
L
L
V
L
-------
C
A
G
V
T
F
S
M
A
R
-
W
M
P
E
T
R
P
V
D
A
P
R
T
R
-----------
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
-----------------------------------------------------------------
15
HHSearch
43.45
16%
-127
- C2 -
2CFQ
-
LACY_ECOLI
A:
[257-392]
-------------------------------------------------------------------------------------------
G
T
---
R
V
F
----
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
----
I
I
N
R
I
G
---------
G
K
N
A
------
L
L
L
A
---
G
T
I
M
S
---
V
R
I
I
G
S
S
F
A
T
S
----
A
L
----
E
V
V
I
L
K
T
L
H
M
F
----
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
--
E
V
R
F
S
--------
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
--------
F
T
L
I
S
-
V
F
T
L
S
-------
G
-------
P
G
P
L
-------
S
------
L
-------------
L
------
R
R
------
Q
V
-----
N
E
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------