@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S19A3_HUMAN: (2015-12-09 )
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
Atome Classification :
(20 SA)
---------.........10........20....--...--.-30.....-...40........50.......-.60........70..--......80.....-...90--.........100-.----..-......110--.....-...-.-120........130.--......140-.......150.......160.......170.......180.......190.......200-.......210.......---------220.......230.......240.......250.......260.......270.....--..280.......290.......300.......310---------.......320.......330.....---..340....-...350.......360....----...370.......380.......390......---..400.......410.......420.......430.......440.......450.....---..460.......----470.......480.......490....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MDCYRTSLSSS
W
I
Y
P
T
V
I
L
C
L
F
G
F
F
--
S
MM--R-PSE
P
F
L
I
-PYLSGPDKNL
T
S
A
E
I
TNEIF
P
V
-
W
T
Y
S
Y
L
V
L
L
L
P
V
F
V
L
--
T
D
YVRYK
P
V
I
I
LQ-
G
I
S
F
---
I
I
T
W
L
L
L
L
FG---Q----GV-
K
T
M
Q
V
V
E
----
F
F
Y
G
M
-
V
T
A
-
A
-
E
-
V
A
Y
Y
A
Y
I
Y
S
VV
S
P
--
E
H
Y
Q
R
V
S
G
Y
-
C
R
S
V
T
L
A
A
Y
T
A
G
S
V
L
A
Q
L
L
V
S
L
ANM
S
Y
F
Y
L
N
V
I
S
L
A
S
V
S
V
A
F
L
F
S
L
FLPMPKKS
M
F
F
HAK-P
S
R
E
IKKSSSVN
P
V
L
E
E---------THEGEAPGCEEQK
P
T
S
E
I
L
STSGKLNKGQLNSLKPSNV
T
V
D
V
F
V
Q
W
F
Q
D
L
K
E
C
Y
SSK
R
--
L
F
Y
W
S
L
W
W
A
F
A
T
A
G
F
N
Q
V
L
N
Y
V
Q
I
L
WDYKAPSQDS---------
S
I
Y
N
G
A
V
E
A
I
A
TFG
G
A
V
A
A
F
A
V
G
Y
V
---
K
V
N
W
D
L
L
G
E
-
L
A
L
V
V
F
S
V
VNA
G
S
L
F
L
M
H
YT----
A
N
I
W
A
C
Y
A
G
Y
L
IFKSS
Y
M
L
L
I
T
I
A
-
V
F
Q
I
A
V
N---LN
V
E
R
Y
A
L
V
F
G
I
N
T
F
I
A
L
V
I
Q
T
I
M
T
V
I
V
V
DQRGLNL
P
V
S
I
Q
F
L
V
Y
G
S
Y
F
A
V
I
A
G
I
F
L
M
R
S
---
M
Y
I
T
YSTKSQKD----VQSPAPSENPDVSHPEEES
N
I
I
M
STKL
26
Fugue
79.75
20%
-118
- C3 -
4R5O
3
?
A:
[2-427]
---------
D
D
C
E
D
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
--
S
Q
V
--
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
--
S
C
I
I
K
N
K
Y
G
K
V
-
E
M
S
T
S
F
---
S
S
N
H
N
---
F
S
---
K
----
G
-------------
F
F
Y
---
V
A
D
-
G
-
T
-
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
--
D
C
Y
A
S
L
N
A
G
--
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
-------
N
G
K
F
Y
L
L
V
G
T
--------------
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
-----------------
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
-
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
--------------
R
L
L
--
C
F
Y
N
S
I
I
Y
N
------
G
K
V
L
S
N
-----
D
T
Y
K
D
E
S
K
V
---------
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
QK
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
----
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
----------
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
-----
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
----
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
SG
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N
-
18
Fugue
58.53
9%
-109
- C4 -
1PV6
-
LACY_ECOLI
A:
[1-417]
---------
M
Y
Y
L
K
N
--
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
--
G
A
Y
--
F
-
P
F
F
P
I
W
L
-
H
D
I
N
H
I
-----
S
K
S
D
T
G
I
I
F
A
A
-
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
--
S
D
K
L
G
L
R
K
Y
L
L
W
I
-
I
T
G
M
---
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
-
P
L
L
Q
Y
N
I
----
L
V
G
S
I
-
V
G
G
-
I
-
Y
-
L
G
F
-------
C
F
N
--
A
G
A
P
A
V
E
A
F
-
I
E
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
-
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
---------
S
A
F
S
------------------------------------------
L
K
L
A
L
E
L
F
R
Q
P
K
--
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
--
T
S
F
F
A
T
G
---------
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
---
P
L
I
I
N
R
I
G
G
-
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
----
A
T
-----
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
-
F
L
L
V
G
C
F
---
K
Y
I
T
S
Q
F
E
--------
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
---
L
V
A
L
G
F
T
L
I
S
V
F
----
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------
27
Fugue
51.28
8%
-109
- C2 -
2I7X
-
CFT2_YEAST
A:
[1-717]
M
T
Y
K
Y
N
C
C
D
D
G
S
G
T
T
V
G
S
V
V
R
F
D
N
V
T
L
L
I
D
P
G
W
N
--
P
S
K
--
V
-
S
Y
E
Q
C
I
K
-
Y
W
E
K
V
I
P
E
-------
I
D
V
I
I
L
S
-
Q
P
T
I
E
C
L
G
A
H
S
L
L
Y
Y
N
F
T
S
H
F
I
S
R
I
Q
V
Y
A
T
-
L
P
V
I
---
N
L
G
R
V
S
T
I
D
S
---
Y
----
A
S
-
A
G
V
I
G
-
P
----
Y
D
T
N
K
-
L
D
L
-
E
-
D
-
I
E
I
S
F
D
H
I
V
P
L
K
Y
--
S
Q
L
V
D
L
R
S
R
-
Y
D
G
L
T
L
L
A
Y
N
A
G
V
C
P
G
G
S
I
W
C
I
S
T
Y
S
E
K
L
V
Y
A
K
R
W
N
H
T
R
D
N
I
L
N
A
A
S
I
L
----------
D
-
A
T
G
K
P
L
S
T
L
M
R
P
S
A
I
I
T
---------
T
L
D
R
F
G
S
S
Q
P
F
K
K
R
S
K
I
F
K
D
T
L
K
K
G
L
S
S
D
G
S
V
I
I
P
V
D
M
-
S
G
K
F
L
D
L
F
T
Q
V
H
E
L
L
F
E
S
Q
V
P
V
L
I
L
S
Y
A
R
G
R
T
L
T
Y
A
K
S
M
L
E
W
L
S
P
S
L
L
K
T
W
E
N
R
N
N
TSPFEIGSR
I
K
I
I
A
P
N
E
L
S
K
Y
P
G
S
K
I
C
F
V
S
E
V
G
A
---
L
I
N
E
V
I
I
K
V
-
G
N
S
E
K
T
T
L
I
L
T
K
P
S
F
E
C
A
S
S
----
L
D
K
I
L
E
I
V
E
Q
D
E
D
G
K
S
F
L
C
D
N
Y
I
S
-
I
D
T
I
K
E
E
P
LS
K
E
E
T
N
F
D
N
L
D
Y
L
K
I
D
K
T
L
S
K
R
T
I
S
T
V
N
V
Q
L
K
C
S
V
V
I
L
N
L
Q
S
L
V
D
Q
R
S
A
S
I
I
W
P
S
L
K
S
R
K
I
---
V
L
S
A
P
K
Q
I
Q
N
E
E
----
I
T
A
K
L
I
K
K
N
I
E
V
V
N
M
P
L
N
K
I
V
E
F
S
---
11
HHSearch
48.11
17%
-122
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[22-178]
------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
--
W
A
V
A
N
N
-
L
N
D
I
L
L
P
-
Q
F
Q
--
Q
A
F
T
L
T
N
F
Q
A
-
G
L
I
Q
S
A
-
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
--
M
K
K
L
S
Y
K
A
G
I
I
T
G
-
L
F
L
Y
---
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
-
T
L
F
L
V
G
L
----
F
I
I
A
A
-
G
L
G
-
C
L
E
-
T
A
A
N
P
F
V
T
V
L
G
P
E
--
S
S
G
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
-
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
---------
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
--
T
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
---------
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
---
A
L
T
L
C
S
A
F
M
-
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
----
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
-
D
A
A
G
N
I
P
---
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------------
7
HHSearch
47.35
13%
-121
- C4 -
3WDO
-
?
A:
[29-176]
--------------------------------------------
V
L
P
V
L
T
-
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
-
G
I
A
I
G
I
-
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
--
S
D
R
I
G
R
K
P
L
I
V
G
G
-
L
A
V
F
---
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
I
I
L
G
R
----
A
L
Q
G
S
-
G
A
--
I
-
A
-
A
A
V
M
A
L
L
S
D
L
T
R
E
--
Q
N
R
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
K
--
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
-
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
---------
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
--
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
---------
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
---
A
G
Y
K
G
T
A
M
G
-
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
----
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
-
S
T
M
K
E
P
P
---
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
---
Q
A
L
----------------------------------------
5
PsiBlast_PDB
45.68
24%
-150
- C4 -
4Q2G
1
CDSA_THEMA
A:
[37-144]
--------------------------------------------------------------------------------------
F
V
V
--
L
C
F
V
S
Y
E
S
L
I
G
L
----------
V
S
A
I
L
I
L
A
G
---
Y
----
E
L
-
I
T
L
E
M
K
E
R
D
A
R
F
F
Y
V
I
-
L
-------
L
A
L
Y
P
V
L
Y
G
L
V
F
E
--
E
P
T
Q
P
L
S
---------
I
L
F
I
T
G
V
V
F
S
L
I
T
D
K
D
P
S
Q
V
F
K
T
V
A
A
F
S
I
A
L
I
Y
V
T
F
F
L
S
F
F
L
P
I
Y
R
D
F
G
A
A
N
A
L
-
L
V
L
T
S
T
W
V
F
D
S
F
A
Y
F
T
G
---------
L
K
F
G
R
T
R
I
S
P
R
Y
S
P
R
K
S
L
E
G
V
I
G
G
F
L
G
V
V
I
Y
T
F
L
Y
R
L
V
V
N
D
L
L
S
V
N
V
I
C
F
R
T
F
L
P
F
A
A
--
T
V
A
I
M
D
T
F
G
D
I
F
E
S
A
L
K
R
H
Y
G
V
K
D
S
G
K
T
L
P
G
H
G
G
M
---------
L
D
R
I
D
G
L
L
F
V
A
P
V
C
Y
I
V
F
K
I
L
E
G
V
V
---
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
45.48
20%
-125
- C4 -
4ZP0
1
?
A:
[67-188]
----------------------------------------------------------------------------------------
L
--
S
D
R
I
G
R
R
P
V
M
L
A
G
-
V
V
W
F
---
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
F
T
L
L
R
----
F
L
Q
G
I
S
L
C
F
-
I
-
G
-
A
V
G
Y
A
A
I
R
E
S
F
E
E
--
A
V
C
I
K
I
T
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
---
F
F
G
L
Q
R
A
M
P
E
T
A
T
R
I
G
E
K
-
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
---------
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
--
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
H
A
---------
Y
L
W
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
N
A
G
L
V
R
L
---
T
L
F
A
S
D
M
S
K
-
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
----
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
V
N
G
I
L
-
W
L
S
L
M
V
I
---
F
L
K
-------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.16
20%
-123
- C4 -
4ZOW
1
?
A:
[66-187]
----------------------------------------------------------------------------------------
L
--
S
D
R
I
G
R
R
P
V
M
L
A
G
-
V
V
W
F
---
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
F
T
L
L
R
----
F
L
Q
G
I
S
L
C
F
-
I
-
G
-
A
V
G
Y
A
A
I
R
E
S
F
E
E
--
A
V
C
I
K
I
T
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
---
F
F
G
L
Q
R
A
M
P
E
T
A
T
R
I
G
E
K
-
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
---------
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
--
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
H
A
---------
Y
L
W
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
N
A
G
L
V
R
L
---
T
L
F
A
S
D
M
S
K
-
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
----
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
V
N
G
I
L
-
W
L
S
L
M
V
I
---
F
L
K
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
44.90
20%
-125
- C4 -
4ZP2
-
?
A:
[67-188]
----------------------------------------------------------------------------------------
L
--
S
D
R
I
G
R
R
P
V
M
L
A
G
-
V
V
W
F
---
I
V
T
C
L
A
I
L
L
A
---
Q
----
N
I
-
E
Q
F
T
L
L
R
----
F
L
Q
G
I
S
L
C
F
-
I
-
G
-
A
V
G
Y
A
A
I
R
E
S
F
E
E
--
A
V
C
I
K
I
T
A
L
-
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
P
W
E
G
M
F
V
L
F
A
A
L
A
A
I
S
---
F
F
G
L
Q
R
A
M
P
E
T
A
T
R
I
G
E
K
-
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
---------
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
G
E
Q
L
S
S
Y
E
Y
G
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
--
L
T
S
R
R
T
V
R
S
L
I
I
M
G
G
W
P
I
M
I
G
L
L
V
A
A
A
A
T
V
I
S
S
H
A
---------
Y
L
W
M
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
N
A
G
L
V
R
L
---
T
L
F
A
S
D
M
S
K
-
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
----
I
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
V
N
G
I
L
-
W
L
S
L
M
V
I
---
F
L
K
-------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.55
24%
-154
- C4 -
4Q2E
-
CDSA_THEMA
A:
[37-144]
--------------------------------------------------------------------------------------
F
V
V
--
L
C
F
V
S
Y
E
S
L
I
G
L
----------
V
S
A
I
L
I
L
A
G
---
Y
----
E
L
-
I
T
L
E
M
K
E
RD
A
R
F
F
Y
V
I
-
L
-------
L
A
L
Y
P
V
L
Y
G
L
V
F
E
--
E
P
T
Q
P
L
S
---------
I
L
F
I
T
G
V
V
F
S
L
I
T
D
K
D
P
S
Q
V
F
K
T
V
A
A
F
S
I
A
L
I
Y
V
T
F
F
L
S
F
F
L
P
I
Y
R
D
F
G
A
A
N
A
L
-
L
V
L
T
S
T
W
V
F
D
S
F
A
Y
F
T
G
---------
L
K
F
G
R
T
R
I
S
P
R
Y
S
P
R
K
S
L
E
G
V
I
G
G
F
L
G
V
V
I
Y
T
F
L
Y
R
L
V
V
N
D
L
L
S
V
N
V
I
C
F
R
T
F
L
P
F
A
A
--
T
V
A
I
M
D
T
F
G
D
I
F
E
C
A
L
K
R
H
Y
G
V
K
D
S
G
K
T
L
P
G
H
G
G
M
---------
L
D
R
I
D
G
L
L
F
V
A
P
V
S
Y
I
V
F
K
I
L
E
G
V
V
---
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
41.39
13%
-119
- C4 -
1PW4
-
GLPT_ECOLI
A:
[23-180]
---------------
Y
R
R
L
R
W
Q
--
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
--
R
-
K
N
F
A
L
A
M
-
P
Y
L
V
E
--
Q
G
F
S
R
G
D
L
-
G
F
A
L
S
G
-
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
--
S
D
R
S
N
P
R
V
F
L
P
A
G
-
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
-
A
V
M
F
V
L
L
----
F
L
C
G
W
-
F
Q
G
-
M
-
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
--
K
E
R
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
-
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
---------
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
--
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
---------
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
---
G
L
H
A
L
E
L
A
P
-
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
----
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
-
G
G
S
I
L
A
V
---
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------
9
HHSearch
41.21
13%
-92
- C4 -
2CFQ
-
LACY_ECOLI
A:
[23-163]
--------------------------------------
M
--
G
-
A
Y
F
P
F
F
P
-
I
W
L
H
D
I
-
N
H
I
S
K
S
D
T
-
G
I
I
F
A
A
-
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
--
S
D
K
L
G
L
R
K
Y
L
L
W
I
-
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
Y
N
I
L
V
G
S
----
I
V
G
G
I
-
Y
L
G
-
F
C
F
-
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
-
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
---------
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
G
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
--
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
S
A
---------
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
---
T
S
Q
F
E
V
R
F
S
-
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
----
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
-
G
F
T
L
I
S
V
---
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
--------------------------------------------------------------------------------------
25
Fugue
38.09
10%
299
- C4 -
2C1M
-
NUP50_MOUSE
B:
[1-46]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
R
V
A
E
K
E
L
T
D
R
N
W
D
E
---------
E
D
E
V
E
E
M
G
-
T
F
S
V
A
S
E
E
V
M
K
N
R
A
V
K
K
A
K
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
35.28
15%
-88
- C4 -
2GFP
-
EMRD_ECOLI
A:
[38-158]
----------------------------------------------------------
L
N
V
R
E
G
A
V
-
Q
S
V
M
G
A
-
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
--
S
D
R
V
G
R
R
P
V
I
L
V
G
-
M
S
I
F
---
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
L
I
A
A
S
----
A
M
Q
G
M
-
G
T
G
V
G
-
G
-
V
M
A
R
T
L
P
R
D
L
Y
E
R
--
T
Q
L
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
-
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
---------
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
--
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
---------
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
---
A
G
T
A
G
A
L
V
G
-
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
----
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
35.26
32%
132
- C4 -
4UBS
4
CYP28_STRAW
A:
[100-136]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
F
T
L
K
R
A
A
A
L
R
P
R
I
Q
E
---------
T
V
D
G
L
L
D
A
M
E
A
Q
G
P
P
A
E
L
V
S
A
F
A
L
P
L
P
S
M
V
I
C
A
L
L
G
V
P
Y
A
D
H
D
F
F
E
S
Q
S
R
R
L
L
R
G
P
G
I
--
A
E
V
Q
D
A
R
A
Q
L
D
D
Y
L
Y
A
L
I
D
R
K
R
K
E
P
G
D
G
L
L
D
D
L
I
Q
---------
E
Q
L
N
R
G
T
V
D
R
A
E
L
V
S
L
A
T
L
L
L
I
A
G
H
---
E
T
T
A
N
M
I
S
L
-
G
T
F
T
L
L
R
H
P
E
Q
L
A
E
L
R
A
E
P
G
----
L
M
P
A
A
V
E
E
L
L
R
F
L
S
I
A
D
G
L
L
R
V
A
T
-
E
D
I
E
V
A
G
---
T
T
I
R
A
D
E
G
V
V
F
A
T
S
V
I
N
R
D
A
A
G
F
A
E
P
D
A
L
D
W
H
R
S
A
R
H
H
V
A
F
G
F
G
I
H
Q
C
L
G
Q
N
L
A
R
A
E
M
E
I
---
A
L
G
T
L
F
E
R
L
P
G
L
----
R
L
A
A
P
A
D
E
I
P
F
K
P
G
D
T
I
Q
G
M
L
E
L
P
V
T
W
15
HHSearch
33.84
13%
-90
- C4 -
2CFQ
-
LACY_ECOLI
A:
[277-375]
-----------------------------------------------------------------------------------
F
F
A
P
L
I
--
I
N
R
I
G
G
K
N
A
L
L
L
A
-
G
T
I
M
---
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
V
V
I
L
K
----
T
L
H
M
F
-
E
V
P
-
F
-
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
--
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
-
N
E
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
33.72
19%
159
- C4 -
1Z56
2
LIF1_YEAST
A:
[159-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
L
Y
K
D
I
C
C
V
N
D
-
S
Y
R
N
I
K
E
S
D
S
S
N
R
N
R
V
E
QLAR
E
R
E
L
L
D
K
L
L
E
T
R
D
E
R
T
R
A
M
M
V
T
L
L
N
E
K
K
K
K
I
R
E
L
H
E
I
L
R
Q
N
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
33.35
8%
-93
- C4 -
1PW4
-
GLPT_ECOLI
A:
[63-164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
---
S
D
R
S
N
P
R
---
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
-
G
R
T
M
V
H
W
---
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
---
R
D
T
P
Q
S
C
G
L
P
P
I
----
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
22
Fugue
31.85
13%
188
* C4 *
3BRV
-
NEMO_HUMAN
B:
[49-109]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
Q
R
C
L
E
E
-
N
Q
E
L
R
D
A
I
R
Q
S
N
Q
I
L
R
E
---------
R
C
E
E
L
L
H
F
Q
A
S
Q
R
E
E
K
E
F
L
M
C
K
F
Q
E
A
R
K
L
V
E
R
L
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
31.20
8%
-37
- C4 -
3WDO
-
?
A:
[306-391]
------------------------------------------------------------------------------------------------------------------------------------------
G
V
----
Q
L
F
F
V
-
A
F
N
L
M
-
E
-
A
L
L
P
S
L
I
S
K
E
S
P
A
--
G
Y
K
G
T
A
M
G
V
-
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
--
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
-
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
---------
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------