@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AD_HUMAN: (2015-12-09 )
MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF
Atome Classification :
(20 SA)
-----------.........10........20.....-...30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150..----.....160.......-170--.....---...180.------------------.-------------.---.----.-------.----.190.......200..----...-----------..210...-----.....220.....-...230........--------240.---------..-----------.----.--..-----------250.......260...-..--..270----.....-...-280-----........290.----.-..-...300.......310-------........320........330.......340---------------..-------.......350.-------....-.---.360.--..---...-..-----------.370..------.....380.......-390........400-.--.-.....---..-----410-.........420..--.....430---------...------...-----...440----.........450....-.--------..460..-...----..470--.--------.-.-..-....480.......490..-..-..-.-------500.......510....--...520.......530.......540.......550--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------M
A
Q
F
V
Q
V
L
A
EIGDF
G
R
F
Q
I
Q
L
L
I
L
L
C
-
V
L
N
F
L
S
P
F
Y
F
F
A
H
V
F
M
V
LDEPH
H
C
A
V
A
W
VKNHTF
N
L
S
A
A
E
Q
L
V
L
SVPLDTAGHPE
P
C
L
M
F
RPPPANA
S
L
Q
D
I
L
S
H
RFNETQPCDMGWEYPENRL
P
S
L
K
N
E
F
N
L
VCD
R
K
H
L
K
D
T
T
Q
S
V
F
M
A
G
L
L
V
G
T
L
M
----
F
G
P
L
C
D
RIG
R
K
A
T
I
L
-
A
Q
---
L
L
L
F
T
---
L
I
G
L
A
T
A
------------------
F
-------------
V
---
P
----
S
-------
F
----
E
L
Y
M
A
L
R
F
A
V
A
T
A
V
AG----LSF-----------S
N
V
-
T
L
L
T
-----EWVGPS-W
R
T
Q
A
V
-
V
L
A
QC-NF
S
L
G
Q
M
V
--------
L
A
G
L
---------
A
Y
-----------G----F--RN-----------
W
R
L
L
Q
I
TGTA
P
G
L
L
L
F
-
F
Y
--
F
WAL-----PESA
R
-
W
L
L
-TR------G
R
M
D
E
A
I
Q
L
I
Q
K
----
A
-
A
S-VNRRKL
S
P
E
L
M
N
Q
LV--------PEKTGPSGN-
A
L
D
LFRHPQ
L
R
K
V
T
L
I
I
F
C
V
-----------------
W
F
-------
V
DSLGYY
G
L
S
L
-------
Q
VGD-F---
G
L
--
D
--
V
Y
---
L
T
Q
-
L
I
-----------
F
G
A
VEV------
P
A
R
C
S
S
I
F
M
M
Q
R
F
G
R
-
K
-
W
S
Q
L
G
T
L
V
L
G
---
G
--
L
-
M
C
I
I
I
---
I
F
-----I---PA
D
L
P
V
V
V
T
M
L
A
V
V
--
G
K
M
A
T
A
-----------
A
A
F
------
T
I
S
-----
Y
V
YS------
A
E
L
F
P
T
I
L
R
QTG
M
G
L
V
-
G
--------
I
F
S
R
I
G
G
-
I
L
T
----
P
L
V
----
I
--------
L
-
L
-
G
E
-
Y
H
A
A
L
P
M
L
I
YGS
L
P
I
V
A
G
L
-
L
C
-
T
L-L-------PETHGQ
G
L
K
D
T
L
Q
DLEL--GPHPRSPKSVPSE
K
E
TEAKGRTSSP
G
V
A
F
VSSTYF---------------
18
Fugue
88.59
19%
-122
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------
Y
N
S
S
Y
I
F
S
I
T
-
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
------------------------------------------
E
S
A
A
N
S
L
L
G
F
C
V
A
--------------------------
S
A
L
I
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
-------------
A
---
G
----
Y
-------
V
----
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
-----------
L
S
P
-
M
Y
I
A
-----
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
-----------
F
----
I
--
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-
S
R
------
G
K
Q
E
Q
A
E
G
I
L
R
K
----
I
-
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
--------
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----------------
F
V
G------
I
N
V
V
L
Y
Y
A
P
E
V
F
K
-----
T
L
G
A
-
S
---
T
D
--
I
--
A
L
---
L
Q
T
-
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-
K
P
L
Q
I
I
G
A
L
G
M
A
---
I
--
G
-
M
F
S
L
G
---
T
A
-----
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
--
A
A
F
A
M
S
-----------
W
G
-------
P
V
C
-----
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
-
M
M
D
----
K
N
S
----
W
--------
L
-
V
-
A
H
-
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
-
F
M
-
W
K
F
V
-------
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------------------------------------------
15
PsiBlast_PDB
82.78
23%
-123
- C1 -
4ZWC
3
?
A:
[90-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
V
G
G
M
I
G
S
F
S
----
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
---
L
L
A
V
T
G
G
C
F
M
G
L
C
K
V
--------------------------------
A
---
K
----
S
-------
V
----
E
M
L
I
L
G
R
L
V
I
G
L
-
F
C
G
----
L
C
T
-----------
G
F
V
-
P
M
Y
I
-----
G
E
I
S
P
T
A
L
R
G
A
F
G
-
T
L
N
Q
L
-
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
L
---------
E
F
-----------
I
----
L
--
G
S
EEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
-----
P
E
S
P
R
-
F
L
L
I
N
R
------
K
E
E
E
N
A
K
Q
I
L
Q
R
----
L
W
G
T
-
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--------
R
M
S
Q
E
K
Q
V
T
-
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-----------------
Q
L
S
Q
Q
LSG-
I
N
A
V
F
Y
Y
S
T
G
I
--------
F
K
D
-
A
---
G
V
--
Q
EP
I
Y
---
A
T
--
I
G
-----------
A
G
V
V
N
T
------
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
-
R
---
T
L
H
M
I
G
L
G
---
G
--
M
A
F
C
S
T
L
---
M
T
-----
V
---
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
-----------
V
A
F
F
E
I
GPG
P
I
P
-----
W
F
I
V
------
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--------
C
S
N
W
T
S
N
-
F
L
V
----
G
L
L
----
F
--------
P
-
S
-
A
A
-
H
Y
L
G
A
Y
V
F
I
-----
I
F
T
G
F
-
L
I
-
T
F
-
L
A
F
T
F
F
KV
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
--
Q
A
H
-----------------------------------------------
13
PsiBlast_PDB
81.44
23%
-124
- C1 -
4ZW9
4
?
A:
[90-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
V
G
G
M
I
G
S
F
S
----
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
---
L
L
A
V
T
G
G
C
F
M
G
L
C
K
V
--------------------------------
A
---
K
----
S
-------
V
----
E
M
L
I
L
G
R
L
V
I
G
L
-
F
C
G
----
L
C
T
-----------
G
F
V
-
P
M
Y
I
-----
G
E
I
S
P
T
A
L
R
G
A
F
G
-
T
L
N
Q
L
-
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
L
---------
E
F
-----------
I
----
L
--
G
S
EEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
-----
P
E
S
P
R
-
F
L
L
I
N
R
------
K
E
E
E
N
A
K
Q
I
L
Q
R
----
L
W
G
T
-
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--------
R
M
S
Q
E
K
Q
V
T
-
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-----------------
Q
L
S
Q
Q
L
SG-
I
N
A
V
F
Y
Y
S
T
G
I
--------
F
K
D
-
A
---
G
V
--
Q
E
P
I
Y
---
A
T
--
I
G
-----------
A
G
V
V
N
T
------
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
-
R
---
T
L
H
M
I
G
L
G
---
G
--
M
A
F
C
S
T
L
---
M
T
-----
V
---
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
-----------
V
A
F
F
E
IGPG
P
I
P
-----
W
F
I
V
------
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--------
C
S
N
W
T
S
N
-
F
L
V
----
G
L
L
----
F
--------
P
-
S
-
A
A
-
H
Y
L
G
A
Y
V
F
I
-----
I
F
T
G
F
-
L
I
-
T
F
-
L
A
F
T
F
F
KV
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
--
Q
A
H
-----------------------------------------------
14
PsiBlast_PDB
81.38
23%
-122
- C1 -
4ZWB
1
?
A:
[90-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
V
G
G
M
I
G
S
F
S
----
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
---
L
L
A
V
T
G
G
C
F
M
G
L
C
K
V
--------------------------------
A
---
K
----
S
-------
V
----
E
M
L
I
L
G
R
L
V
I
G
L
-
F
C
G
----
L
C
T
-----------
G
F
V
-
P
M
Y
I
-----
G
E
I
S
P
T
A
L
R
G
A
F
G
-
T
L
N
Q
L
-
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
L
---------
E
F
-----------
I
----
L
--
G
S
EEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
-----
P
E
S
P
R
-
F
L
L
I
N
R
------
K
E
E
E
N
A
K
Q
I
L
Q
R
----
L
W
G
T
-
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--------
R
M
S
Q
E
K
Q
V
T
-
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-----------------
Q
L
S
Q
Q
L
SG-
I
N
A
V
F
Y
Y
S
T
G
I
--------
F
K
D
-
A
---
G
V
--
Q
E
P
I
Y
---
A
T
--
I
G
-----------
A
G
V
V
N
T
------
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
-
R
---
T
L
H
M
I
G
L
G
---
G
--
M
A
F
C
S
T
L
---
M
T
-----
V
---
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
-----------
V
A
F
F
E
I
GPG
P
I
P
-----
W
F
I
V
------
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--------
C
S
N
W
T
S
N
-
F
L
V
----
G
L
L
----
F
--------
P
-
S
-
A
A
-
H
Y
L
G
A
Y
V
F
I
-----
I
F
T
G
F
-
L
I
-
T
F
-
L
A
F
T
F
F
KV
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
--
Q
A
H
-----------------------------------------------
6
PsiBlast_PDB
80.42
21%
-103
- C1 -
4J05
-
?
A:
[55-515]
-------------------------------------------------------------------------------------------------------------------
N
Q
V
A
P
M
L
A
Q
V
Y
F
P
K
T
G
L
P
A
Q
R
------------
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
----
F
G
V
L
G
D
S
F
G
R
K
F
V
Y
G
-
K
E
---
L
I
L
I
I
---
V
A
T
I
F
Q
M
------------------
S
-------------
A
---
P
----
S
HWD
G
N
R
V
L
----
T
W
I
T
I
C
R
V
F
L
G
I
G
I
G
G
----
D
Y
P
-----------
M
S
A
-
T
V
V
S
-----
D
R
A
N
I
H
-
R
R
G
T
L
L
-
C
F
I
F
A
-
N
Q
G
W
G
S
F
V
G
S
L
V
T
I
V
T
I
S
G
F
---------
K
H
-----------
R
----
L
--
K
S
GHTHD
V
D
K
A
--
W
R
I
L
I
G
L
S
L
I
P
A
F
G
T
L
-
Y
Q
--
R
----------------------------------------------------------------------------------------------
W
Q
E
F
V
A
Y
F
STWNHF
R
N
L
L
G
S
M
L
G
W
F
-------
L
V
D
I
A
F
Y
G
I
N
L
N
QSVV
L
A
Q
I
G
F
-
A
---
G
K
TG
D
--
V
Y
D
K
-
L
F
Q
-
L
A
-----------
T
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
G
R
-
K
-
K
L
Q
F
M
G
F
I
M
S
---
G
--
L
-
F
L
A
I
L
A
G
E
I
D
-----
H
---
I
G
K
G
P
L
L
A
C
F
T
F
M
Q
--
F
F
F
N
F
G
-----------
A
N
-------
T
T
T
-----
F
I
V
A
------
A
E
L
F
P
T
R
I
R
A
S
A
H
G
I
S
-
A
--------
A
A
G
K
C
G
A
-
I
L
S
----
S
L
V
----
F
N
Q
------
L
-
K
-
A
K
-
I
G
T
S
A
V
L
W
I
F
F
S
T
C
I
L
G
F
I
-
S
T
-
F
L
-
I
-------
D
E
T
--
M
G
V
D
P
D
E
K
D
L
E
E
--
R
R
A
R
----------------------------------------------
19
Fugue
79.31
21%
-109
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
----------------------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
------------------
T
V
E
S
L
N
T
V
--------------
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
---------
A
S
A
L
I
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY
L
-------------
A
---
G
----
Y
-------
V
----
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
----
A
S
M
-----------
L
S
P
-
M
Y
I
A
-----
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
-----------
F
----
I
--
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-
T
--------
L
A
T
Q
A
V
Q
E
I
K
H
----
S
-
L
D
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
--------
S
I
F
Q
Q
F
V
G
I
-
N
V
V
L
Y
Y
A
P
E
V
F
K
----------------------------------------------------
T
L
G
A
-
S
---
T
D
--
I
--
A
L
---
L
Q
T
-
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
-
L
Q
I
I
G
A
L
G
M
A
---
I
--
G
-
M
F
S
L
G
---
T
A
-----
F
---
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
--
F
Y
V
A
A
F
-----------
A
M
S
WG----
P
V
C
-----
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
--------
A
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
M
DKN
S
W
--------
L
-
V
-
A
H
-
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
-
F
M
W
K
F
-
V
-------
P
E
T
K
G
K
T
L
-------------------------------------------------------------
16
PsiBlast_PDB
78.87
22%
-119
- C1 -
5C65
8
?
A:
[68-469]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
V
G
G
M
I
G
S
F
S
----
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
---
L
L
A
V
T
G
G
C
F
M
G
L
C
K
V
--------------------------------
A
---
K
----
S
-------
V
----
E
M
L
I
L
G
R
L
V
I
G
L
-
F
C
G
----
L
C
T
-----------
G
F
V
-
P
M
Y
I
-----
G
E
I
S
P
T
A
L
R
G
A
F
G
-
T
L
N
Q
L
-
G
I
V
V
G
I
L
V
A
Q
------
I
F
G
L
---------
E
F
-----------
I
----
L
--
G
S
EEL--------
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
-----
P
E
S
P
R
-
F
L
L
I
N
R
------
K
E
E
E
N
A
K
Q
I
L
Q
R
----
L
W
G
T
-
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--------
R
M
S
Q
E
K
Q
V
T
-
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-----------------
Q
L
S
Q
Q
L
SG-
I
N
A
V
F
Y
Y
S
T
G
I
--------
F
K
D
-
A
--------P-
I
Y
---
A
T
--
I
G
-----------
A
G
V
V
N
T
------
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
-
R
---
T
L
H
M
I
G
L
G
---
G
--
M
A
F
C
S
T
L
---
M
T
-----
V
---
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
-----------
V
A
F
F
E
I
GPG
P
I
P
-----
W
F
I
V
------
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
--------
C
S
N
W
T
S
N
-
F
L
V
----
G
L
L
----
F
--------
P
-
S
-
A
A
-
H
Y
L
G
A
Y
V
F
I
-----
I
F
T
G
F
-
L
I
-
T
F
-
L
A
F
T
F
F
KV
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
--
Q
A
------------------------------------------------
1
PsiBlast_PDB
76.45
23%
-119
- C1 -
4LDS
-
?
A:
[39-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
L
N
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
-
L
I
---
A
I
V
F
I
---
I
G
A
L
I
L
A
------------------
A
-------------
S
---
T
----
N
-------
L
----
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
-----
S
M
-----------
S
T
V
P
V
Y
L
S
-----
E
M
A
P
T
E
-
Y
R
G
S
L
G
-
S
L
N
Q
L
-
M
I
T
I
G
I
L
A
--------
A
Y
L
V
---------
N
Y
-----------
A
----
F
--
A
D
I
E
G
--------
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
-
V
G
--
I
Y
F
M
-----
P
E
S
P
R
-
W
L
L
--
E
------
N
R
N
E
E
A
A
R
Q
V
M
K
------
I
T
-
Y
D
D
S
E
I
D
K
E
L
--
K
E
M
--------
K
E
I
N
A
I
S
E
S
-
T
W
T
V
I
K
S
P
W
L
G
R
I
-
L
I
V
G
C
I
-----------------
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
FA-----
K
A
G
L
-
G
---
E
A
--
A
--
S
I
---
L
G
S
-
V
G
-----------
I
G
T
I
N
V
------
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
-
K
------
K
L
L
V
G
---
G
--
N
-
I
G
M
I
----------------
A
S
L
L
I
M
A
I
L
I
W
T
I
--
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
------
G
I
S
WGP
V
L
W
V
M
L
------
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
-
A
--------
L
V
L
N
I
G
T
-
L
I
V
----
S
L
F
FP--
I
--------
L
-
S
-
D
A
-
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
-
K
F
-
L
-------
P
E
T
R
G
----------------------------------------------------------------
4
PsiBlast_PDB
76.05
20%
-107
- C1 -
4GC0
5
XYLE_ECOLI
A:
[67-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-------
Y
----
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
----
I
G
V
-----------
G
L
A
-
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
F
I
A
R
S
GD
A
S
W
L
N
----
T
--
D
G
-----------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-
S
R
------
G
K
Q
E
Q
A
E
G
I
L
R
K
----
I
-
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
--------
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----------------
F
V
G------
I
N
V
V
L
Y
Y
A
P
E
V
F
------
K
T
L
G
-
A
---
S
T
--
D
--
I
A
---
L
L
Q
T
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-
K
-
P
L
Q
----
I
I
G
---
A
--
L
-
G
M
A
I
G
---
M
F
S
L
G
T
A
F
---
Y
T
Q
A
P
G
I
V
A
L
L
S
M
-----
L
F
Y
V
-----------
A
A
F
------
A
M
S
WG
P
V
C
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
--------
A
A
Q
W
L
A
N
-
Y
F
V
----
S
W
T
----
F
P
M
M
D
K
N
S
W
L
-
V
-
A
H
-
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
-
K
F
-
V
-------
P
E
T
K
G
K
----
T
L
E
E
L
E
A
--
L
W
E
-----------------------------------------------
2
PsiBlast_PDB
74.33
20%
-108
- C1 -
4GBY
5
XYLE_ECOLI
A:
[67-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-------
Y
----
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
----
I
G
V
-----------
G
L
A
-
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
F
I
A
R
SGD
A
S
W
L
N
----
T
--
D
G
-----------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-
S
R
------
G
K
Q
E
Q
A
E
G
I
L
R
K
----
I
-
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
--------
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----------------
F
V
G------
I
N
V
V
L
Y
Y
A
P
E
V
F
------
K
T
L
G
-
A
---
S
T
--
D
--
I
A
---
L
L
Q
T
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-
K
-
P
L
Q
----
I
I
G
---
A
--
L
-
G
M
A
I
G
---
M
F
S
L
G
T
A
F
---
Y
T
Q
A
P
G
I
V
A
L
L
S
M
-----
L
F
Y
V
-----------
A
A
F
------
A
M
S
WG
P
V
C
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
--------
A
A
Q
W
L
A
N
-
Y
F
V
----
S
W
T
----
F
P
M
M
D
K
N
S
W
L
-
V
-
A
H
-
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
-
K
F
-
V
-------
P
E
T
K
G
K
----
T
L
E
E
L
E
A
--
L
W
E
-----------------------------------------------
3
PsiBlast_PDB
73.96
20%
-108
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[67-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-------
Y
----
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
----
I
G
V
-----------
G
L
A
-
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
F
I
A
R
S
GD
A
S
W
L
N
----
T
--
D
G
-----------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-
S
R
------
G
K
Q
E
Q
A
E
G
I
L
R
K
----
I
-
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
--------
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----------------
F
V
G------
I
N
V
V
L
Y
Y
A
P
E
V
F
------
K
T
L
G
-
A
---
S
T
--
D
--
I
A
---
L
L
Q
T
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-
K
-
P
L
Q
----
I
I
G
---
A
--
L
-
G
M
A
I
G
---
M
F
S
L
G
T
A
F
---
Y
T
Q
A
P
G
I
V
A
L
L
S
M
-----
L
F
Y
V
-----------
A
A
F
------
A
M
S
WGP
V
C
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
--------
A
A
Q
W
L
A
N
-
Y
F
V
----
S
W
T
----
F
P
M
M
D
K
N
S
W
L
-
V
-
A
H
-
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
-
K
F
-
V
-------
P
E
T
K
G
K
----
T
L
E
E
L
E
A
--
L
W
E
-----------------------------------------------
21
Fugue
72.59
16%
-96
- C1 -
4UZY
-
?
A:
[9-650]
QQPA
R
P
I
A
EGQ
Y
T
Q
T
I
Y
T
L
I
K
E
Q
K
F
A
E
A
I
Q
H
L
Q
Y
Q
L
Q
N
V
P
E
S
R
A
A
L
S
L
L
G
Y
C
Y
Y
Y
T
G
Q
Y
D
M
A
S
Q
M
Y
E
Q
L
V
T
L
Y
P
S
N
E
D
Y
K
L
Y
Y
A
Q
S
L
Y
K
G
G
-------
M
Y
P
E
A
S
K
A
V
V
K
V
E
G
H
Q
K
A
V
T
T
L
-
L
V
A
C
S
Y
E
Q
D
D
L
T
G
C
R
R
Q
L
----
D
K
C
A
P
E
D
P
D
T
M
V
N
T
G
C
I
M
F
K
E
G
K
----
F
E
A
A
R
Q
K
F
N
D
Y
Q
P
E
L
-
L
Y
---
N
I
A
L
C
---
Y
Y
K
T
K
Q
-------------------
F
-------------
G
---
P
----
A
-------
L
----
K
H
L
A
E
I
I
E
K
A
V
R
E
H
P
E
----
L
S
V
GSDGMEVRSVG
N
S
Q
-
T
L
K
E
-----
T
A
L
I
E
A
-
F
N
L
K
A
A
-
I
E
Y
T
M
K
N
V
E
A
A
K
E
A
--------
L
T
D
M
PPRAEEELD
P
V
-----------
T
----
L
--
H
N
-----------
S
A
L
I
N
M
D
S
D
P
T
G
G
F
K
K
-
L
N
--
F
L
L
Q
S
PPFP
P
E
T
F
A
-
N
L
L
-
L
L
Y
C
KPSH
G
F
Y
D
L
A
A
D
V
L
A
E
----
N
-
P
Q
-
Y
A
G
K
L
L
S
P
D
L
Y
D
Y
L
Q
A
A
I
G
R
YKS
P
E
E
A
F
R
R
F
D
-
E
L
A
T
R
H
V
E
Q
L
R
R
L
T
K
Q
I
Q
D
A
-----------------
R
I
-------
A
R
D
N
D
A
I
K
R
A
I
-------
N
E
Y
D
-
E
---
A
L
--
E
--
A
Y
---
I
P
G
-
L
M
A
M
A
S
I
Y
W
D
M
EL
Y
S
N
V
E
K
------
I
F
R
Q
S
A
E
F
C
S
E
H
E
V
W
-
K
-
L
N
V
A
H
T
F
F
M
Q
---
D
NH
Y
-
K
E
A
I
R
---
Y
Y
-----
E
---
P
V
V
K
K
N
A
D
N
L
L
G
V
----
T
A
I
V
L
-----------
A
N
L
------
C
V
S
-----
Y
I
M
T
SQ
N
E
E
A
E
E
L
M
R
K
V
E
K
E
E
E
R
S
S
M
-
Q
--------
D
P
D
K
P
C
F
-
H
L
C
----
I
I
N
----
L
--------
V
-
I
-
G
T
-
L
Y
C
A
K
G
N
Y
E
F
G
V
S
R
I
I
K
S
L
-
E
E
-
T
D
-
T
-------
W
Y
Y
A
K
R
C
F
L
A
L
I
E
N
L
A
K
H
M
I
V
L
K
D
S
S
F
T
E
I
M
A
F
L
N
E
A
E
K
H
G
K
D
I
R
V
V
F
N
Q
S
R
T
I
A
S
E
A
R
M
L
K
K
M
F
L
K
L
R
5
PsiBlast_PDB
67.92
20%
-123
- C1 -
4JA4
-
XYLE_ECOLI
A:
[67-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
I
G
G
A
L
----
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
---
I
S
G
V
G
S
A
------------------
W
PELGF
T
S
I
N
P
D
N
T
V
---
P
----
V
-------
Y
----
L
A
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
----
I
G
V
-----------
G
L
A
-
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
-
I
R
G
K
L
V
-
S
F
N
Q
F
-
A
I
I
F
G
Q
L
L
--------
V
Y
C
V
---------
N
Y
F
I
A
RSGD
A
S
W
L
N
----
T
--
D
G
-----------
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
-----
P
E
S
P
R
-
W
L
M
-----------
Q
E
Q
A
E
G
I
L
R
K
----
I
-
M
G
-
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
--------
D
H
G
---------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
-----------------
F
V
G------
I
N
V
V
L
Y
Y
A
P
E
V
----------------------------
L
L
Q
T
I
I
-----------
V
G
V
I
N
L
------
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-
K
-
P
L
Q
----
I
I
G
---
A
--
L
-
G
M
A
I
G
---
M
F
S
L
G
T
A
F
---
Y
T
Q
A
P
G
I
V
A
L
L
S
M
-----
L
F
Y
V
-----------
A
A
F
------
A
M
S
WGPV
C
W
V
L
L
------
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
--------
A
A
Q
W
L
A
N
-
Y
F
V
----
S
W
T
----
F
P
M
M
DKNSW---------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
-
K
F
-
V
-------
P
E
T
K
G
K
----
T
L
E
E
L
E
A
--
L
W
E
-----------------------------------------------
23
Fugue
66.47
12%
-117
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
---------FK
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
--------------------
N
F
A
L
A
M
P
Y
L
V
E
Q
G
F
S
----------------------------------------------------------
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
----
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
---
A
V
M
L
F
M
G
------------------
F
-------------
V
---
P
----
W
-------
A
T
S
SI
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
-----------
P
C
G
-
R
T
M
V
-----
H
W
W
S
Q
K
-
E
R
G
G
I
V
-
S
V
W
N
C
-
A
H
N
V
G
G
G
I
--------
P
P
L
L
---------
F
L
-----------
L
----
G
--
M
A
-----------
W
-----
F
N
D
W
H
A
A
L
Y
M
-
P
A
--
F
C
A
I
-----
L
V
A
L
F
-
A
F
A
-
M
M
------
R
D
T
P
Q
S
C
G
L
P
P
I
----
E
-
E
Y
-
K
N
D
T
A
------
K
Q
I
F
--------
M
Q
Y
V
L
P
N
K
L
-
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
-----------------
W
S
-------
P
T
Y
L
K
----
E
V
-------
K
H
F
A
-
L
---
D
K
--
S
--
S
W
---
A
Y
F
-
L
Y
-----------
E
Y
A
G
I
P
------
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
-
N
-
R
G
A
T
G
V
F
F
M
T
---
L
--
V
-
T
I
A
T
I
---
V
Y
-----
W
---
M
N
P
A
G
N
P
T
V
D
M
I
C
M
--
I
V
I
G
F
L
I
Y---------
G
P
V
------
M
L
I
-----
G
L
H
A
------
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
--------
L
F
G
Y
L
G
G
-
S
V
A
----
A
S
A
----
I
--------
V
-
G
-
Y
T
-
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
-
A
V
-
I
L
-
L
-------
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
--
L
V
P
-----------------------------------------------
20
Fugue
60.29
14%
-97
- C1 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------------
L
L
L
M
L
V
L
L
V
-
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
L
N
-----------------------------------------------------------------------------------
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
----
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
-
V
G
---
M
S
I
F
M
---
L
A
T
L
V
A
V
------------------
T
-------------
T
---
S
----
S
-------
L
----
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
----
G
G
V
-----------
M
A
R
-
T
L
P
R
-----
D
L
Y
E
R
T
-
Q
L
R
H
A
N
-
S
L
L
N
M
-
G
I
L
V
S
P
L
L
--------
A
P
L
I
---------
G
G
LLD--------
T
----
M
--
W
N
-----------
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
-
F
------------------------------------------------------------
S
M
A
R
W
M
--------
P
E
T
R
P
V
D
A
P
-
R
T
R
L
L
T
S
---------------------------------------------
Y
K
T
L
F
-------
G
N
S
G
-
F
---
N
C
--
Y
--
L
L
---
M
L
I
-
G
G
-----------
L
A
G
I
A
A
------
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
-
S
-
S
M
T
V
S
I
L
F
I
-------------------------------------
L
P
I
P
A
--
A
F
F
G
A
W
-----------
F
A
G
------
R
P
N
-----
K
R
F
S
------
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
-
M
--------
W
I
P
D
W
F
G
-
V
M
N
----
V
W
T
----
L
--------
L
-
V
-
P
A
-
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
-
E
P
-
F
P
-
F
-------
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
--
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L--------------
7
PsiBlast_PDB
60.11
25%
-109
- C1 -
4PYP
1
GTR1_HUMAN
A:
[70-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
V
G
G
M
I
G
S
F
S
----
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
-
M
M
---
N
L
L
A
F
---
V
S
A
V
L
M
G
------------------
F
-------------
S
KLG
K
----
S
-------
F
----
E
M
L
I
L
G
R
F
I
I
G
V
-
Y
C
G
----
L
T
T
-----------
G
F
V
-
P
M
Y
V
-----
G
E
V
S
P
T
-
A
L
R
G
A
L
G
T
L
H
Q
L
-
G
I
V
V
G
--
I
--------
L
I
A
Q
---------
V
F
-----------
G
----
L
--
D
S
IMGNKDL----
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
-
I
V
--
L
P
F
C
-----
P
E
S
P
R
-
F
L
L
I
N
R
------
N
E
E
N
R
A
K
S
V
L
K
K
L
R
GT
A
-
D
V
-
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
--------
R
E
K
---
K
V
T
-
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
-----------------
Q
L
S
Q
QLSG-
I
N
A
V
F
Y
Y
S
T
S
I
F
------
E
K
A
G
-
V
---
Q
Q
--
P
--
V
Y
---
A
T
--
I
G
-----------
S
G
I
V
N
T
------
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
-
R
-
T
L
H
L
I
G
L
A
G
M
---
A
--
G
-
C
A
I
L
M
---
T
I
-----
A
---
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
--
I
V
A
I
F
G
-----------
F
V
A
------
F
F
E
-----
V
G
P
G
------
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
-
P
--------
A
A
I
A
V
A
G
-
F
S
N
----
W
T
S
----
N
--------
F
-
I
-
V
G
-
M
C
F
Q
Y
V
E
Q
L
C
G
P
Y
V
F
I
I
F
T
-
V
L
-
L
V
-
L
-------
F
F
I
F
T
Y
F
K
V
P
E
T
---------------------------------------------------------
27
HHSearch
59.92
14%
-120
- C1 -
1PW4
-
GLPT_ECOLI
A:
[56-443]
----------------------------------------------------------------------------------------------------------------------------------------
V
E
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
----
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
---
A
V
M
L
F
M
G
------------------
F
-------------
V
---
P
W
A
T
S
S
-------
I
----
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
----
G
W
P
-----------
P
C
G
-
R
T
M
V
-----
H
W
W
S
Q
K
-
E
R
G
G
I
V
-
S
V
W
N
C
-
A
H
N
V
G
G
G
I
--------
P
P
L
L
---------
F
L
-----------
L
G
M
AW
F
--
N
D
-----------
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
--
F
A
M
M
-----
R
D
T
P
Q
-
S
C
G
-
L
P
------
P
I
-
E
E
Y
K
N
---
D
------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
-----------------
Y
L
-------
L
R
Y
G
I
L
D
W
S
P
T
-------
Y
L
K
E
V
K
---
H
F
--
A
--
L
D
K
S
S
W
A
Y
-
F
L
-----------
Y
E
Y
A
G
I
------
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
-
G
-
N
R
G
A
T
G
V
F
F
M
T
L
V
T
--
I
-
A
T
I
V
Y
---
W
M
-----
N
---
P
A
G
N
P
T
V
D
M
I
C
M
I
V
--
I
G
F
L
I
Y
-----------
G
P
V
------
M
L
I
-----
G
L
H
A
------
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
--------
L
F
G
Y
L
G
G
S
V
A
A
----
S
A
I
----
V
--------
G
Y
T
-
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
-
L
L
I
V
V
-
M
-------
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------
31
HHSearch
49.84
14%
-101
- C1 -
2CFQ
-
LACY_ECOLI
A:
[42-391]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
----
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
-
W
I
I
T
G
M
L
V
M
F
---
A
P
F
F
I
F
I
------------------
F
-------------
G
---
P
----
L
L
------
Q
----
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
-----------
A
V
E
-
A
F
I
E
-----
K
V
S
R
---
R
S
N
F
E
F
-
G
R
A
R
M
-
F
G
C
V
G
W
A
L
--------
G
A
S
I
---------
V
G
-----------
I
----
M
F
T
I
N
-----------
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
-
V
L
--
L
F
F
A
-----
K
T
D
A
P
-------------
S
S
A
T
V
A
N
A
-------------
V
G
A
N
--------------------
H
S
A
F
S
L
K
L
-
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
-----------------
S
C
-------
T
Y
D
V
F
D
Q
Q
F
A
N
-------
F
F
T
S
F
F
AT
G
E
Q
--
G
--
T
R
V
F
G
Y
V
T
-
T
M
-----------
G
E
L
L
N
A
------
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
-
K
-
N
A
L
L
L
A
G
T
I
M
---
S
--
V
-
R
I
I
G
S
---
S
F
-----
A
---
T
S
--
A
L
E
V
V
I
L
K
T
L
--
H
M
F
E
V
P
-----------
F
L
L
------
V
G
C
-----
F
K
Y
I
------
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
--------
F
F
K
Q
L
A
M
-
I
F
M
----
S
V
L
----
A
--------
G
-
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
-
I
S
-
V
F
-
T
-------
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
--
A
-------------------------------------------------
29
HHSearch
43.45
22%
-110
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[49-173]
-----------------------------------------------------------------------------------------------------------------------------------
L
P
Q
F
Q
Q
A
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
----
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
-
T
G
---
L
F
L
Y
A
---
L
G
A
A
L
F
W
------------------
P
-------------
A
A
E
I
M
----
N
-------
Y
----
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
----
L
E
T
-----------
A
A
N
-
P
F
V
T
-----
V
L
G
P
E
S
-
S
G
H
F
R
L
-
N
L
A
Q
T
-
F
N
S
F
G
A
I
I
--------
A
V
V
F
---------
G
Q
-----------
S
----
L
--
I
L
-----------
S
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
-
E
Q
--
L
S
A
Y
-----
K
H
S
L
V
-
L
S
V
-
Q
T
------
P
Y
M
I
I
V
A
I
V
L
L
V
----
A
-
L
L
-
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
--------
D
A
K
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
-----------------
Y
V
-------
G
A
Q
T
A
C
W
S
Y
L
I
-------
R
Y
A
V
-
E
---
E
I
--
P
--
G
M
---
T
A
G
-
F
A
-----------
A
N
Y
L
T
G
------
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
-
I
-
S
R
F
A
P
H
K
V
L
A
---
A
--
Y
-
A
L
I
A
M
---
A
L
-----
C
---
L
I
S
A
F
A
G
G
H
V
G
L
I
A
--
L
T
L
C
S
A
-----------
F
M
S
------
I
Q
Y
-----
P
T
I
F
------
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
-
F
--------
I
V
M
T
I
I
G
-
G
G
I
----
V
T
P
----
V
--------
M
-
G
-
F
V
-
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
-
V
I
-
F
I
-
F
-------
A
R
F
R
S
Q
T
--------------------------------------------------------------
11
PsiBlast_PDB
39.79
29%
-51
* C2 *
3TRD
-
?
A:
[89-175]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
-
K
A
V
L
-----
R
W
V
E
H
H
-
W
S
Q
D
D
I
-
W
L
A
---
G
F
S
F
G
A
Y
I
--------
S
A
K
V
---------
A
Y
--------------------
D
-----------
Q
K
V
A
Q
L
I
S
V
A
P
P
V
----
F
Y
EG
F
A
S
L
-----
T
Q
M
A
S
P
W
L
I
-
V
Q
------
G
D
Q
D
E
V
V
P
F
E
Q
V
----
K
-
A
F
-
V
N
Q
I
S
S
P
V
E
F
V
V
M
S
G
--------
A
S
H
F
F
H
G
R
L
-
I
E
L
R
E
L
L
V
R
N
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------