@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S23A1_HUMAN: (2015-12-09 )
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFSSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV
Atome Classification :
(20 SA)
---------------.........10........20..--.....----------------------.30...----.....-----40-........50........60-------------------------.....----------.-----------...70--.........80........90.......-----------------------------------.100.----......-------.110.......120.---......130.......140--......------..150.......----------------160.--------......170...---..---------..180.....----------..190.......200....------..-----------.210....---...220.---------......230...--....---240--.........250---........260.......270......------------.280.......290.......300-------.........310.......320-------------........330..------...------..340.---------...----------..-----.350-...-.....360--------....---------------....370..-...--..----------.---------380....----...390--..--...-...----.400----.........410..---.....-420-.......---430-----------------------.....----------------..-------------------.440.....--.-----.--450.......-------460.--------...--------...470........480......-------------------.490.......--500-------.........510-........-----------------------520.....-..530.......540..----------.....550..---.....-----560.......----570.......580.---......590..-----....-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MR
A
Q
EDLEGRTQHETTRDPSTPL--PTEPK----------------------F
D
M
L
Y
K
----IEDV
P
-----
P
W
-
Y
L
C
I
L
L
G
F
Q
H
Y
L
T
C
FSG
T
I
--------------------------
A
V
P
F
L
----------
L
-----------
A
E
A
L
---CVG
H
D
Q
H
M
V
S
Q
L
I
G
T
I
F
T
C
V
G
I
T
T
L
I
Q
T
-----------------------------------TV-GI----RLPLFQ-------AS
A
F
A
F
L
V
P
A
K
A
I
L
A
---
L
E
RWKCP
P
E
E
EIYGNWSL---PLNTSH------IW
H
P
R
I
R
E
V
Q
G
A
----------------
I
M
V
S
--------
S
V
V
E
V
V
I
G
L
LGL---
P
G
---------
A
L
L
N
YIGPLT----------VTP
T
V
S
L
I
G
L
S
V
F
Q
A
AGDR------AG-----------SHW
G
I
S
A
C
---
S
I
L
L
I
I
L
---------
F
S
Q
Y
L
R
N
L
T
F
L
L
--
P
V
Y
R---W----GK
G
L
T
L
L
R
I
Q
I
----
F
K
M
F
P
I
M
L
A
I
M
T
V
W
L
L
C
Y
V
L
T
L
T
DVLP------------TDPKAY
G
F
Q
ARTDARG
D
I
M
A
IA---------PWIRIPYPCQWGL
P
T
V
T
A
A
A
V
--------------
L
G
M
F
S
A
T
L
A
G
I
I
E
------SI
G
------
D
Y
Y
A
C
A
---------
R
LA----------GA-----PPP--
P
V
H
-
A
I
N
R
G
I
F---------TE
G
I
---------------
C
C
I
I
A
G
-
L
L-GTG--NG----------S---------TSSSP
N
I
----
G
V
L
G
----
I
T--KVG-S
R
R
----
V
V
------
Q
Y
G
A
A
I
M
L
V
L
GT
I
G
---
K
F
T
A
L
-
F
S
S-LP
D
P
I
L
G
---
G
M
------------------------
F
C
T
L
F
----------------
G
M
-------------------
I
T
A
VGLS
N
L
--
Q
-----
F
--
V
DMNSSR
N
L
F
-------
V
L
G
F
--------
S
M
F
--------
F
GLT-L
P
N
Y
LESNPGAIN
T
G
I
L
E
-------------------
V
D
Q
I
L
I
V
L
L
T
T
--
E
---------
M
F
V
G
G
C
L
A
F
I
L--DNTVPGSP-----------------------EER
G
L
I
Q
W
-KAGAHANS
D
M
S
S
S
L
KSY----------DFP
I
G
M
G
I
V
K
---
R
I
T
F
L
-----KYIPICPVFK----GFSSSSKD
Q
I
AIPE---DTPENT
E
T
A
S
V-----CTKV-------------------------------
9
HHSearch
94.53
24%
-115
- C3 -
3QE7
2
URAA_ECOLI
A:
[4-410]
---------------------------------------------------------------------
R
A
I
G
----
V
S
E
R
P
-----
P
L
-
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
--------------------------
L
V
P
V
L
----------
F
-----------
H
-------
I
N
---------
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
-----------------------------------
F
I
C
K
G
----
K
I
P
A
Y
L
-------
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
---------------------------------------
L
G
Y
E
V
A
L
G
G
----------------
F
I
M
C
--------
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
---------
W
L
D
V
L
F
P
P
A
A
----------
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
------
A
G
LLPAEGQTPD
S
K
T
I
I
I
S
I
T
---
T
L
A
V
T
V
L
---------
G
S
V
L
F
R
-----------------------------
G
F
----
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
------------------------------
T
T
P
I
I
N
A
---------
H
W
F
A
L
P
T
L
---
Y
T
P
R
F
E
W
F
A
I
--------------
L
T
I
L
P
A
A
L
V
V
I
A
E
------
H
V
G
------
H
L
V
V
T
A
---------
N
I
V
----------
K
K
-----
D
L
L
--
R
D
P
-
G
L
H
R
S
M
F
---------
A
N
G
L
---------------
S
T
V
I
S
G
-
F
F
-
G
S
---
T
P
----------
N
---------
T
T
Y
G
E
N
I
----
G
V
M
A
----
I
T
--
R
V
Y
-
S
T
W
----
V
I
------
G
G
A
A
I
F
A
I
L
L
S
C
V
G
---
K
L
A
A
A
-
I
Q
M
-
I
P
L
P
V
M
G
---
G
V
------------------------
S
L
L
L
Y
----------------
G
V
-------------------
I
G
A
S
G
I
R
V
L
--
I
-----
E
SK
V
D
Y
N
K
A
Q
N
L
I
-------
L
T
S
V
--------
I
L
I
--------
I
G
V
S
-
G
A
K
V
N
I
------------------------------------
G
A
A
E
L
K
--
G
---------
M
A
L
A
T
I
V
G
I
G
L
--
S
L
I
F
K
L
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
93.60
25%
-104
- C3 -
3QE7
2
URAA_ECOLI
A:
[4-410]
---------------------------------------------------------------------
R
A
I
G
----
V
S
E
R
P
-----
P
L
-
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
--------------------------
L
V
P
V
L
----------
F
-----------
H
--------------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
-----------------------------------
C
K
-
G
-----
K
I
P
A
Y
L
-------
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
---
L
G
-----------------------------------
Y
E
V
A
L
G
G
F
----------------
I
M
C
G
--------
V
L
F
C
L
V
S
F
I
V
K
K
---
A
G
T
G
-------
W
L
D
V
L
F
P
P
A
A
----------
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
------
A
G
-----------
L
L
P
A
E
G
Q
T
---
P
D
S
K
T
I
I
---------
I
S
I
T
T
L
A
V
T
V
L
G
--
S
V
L
F
---
R
----
G
---------
F
----
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
------------
I
I
N
------------------
A
---------
H
W
F
A
L
P
---
T
L
Y
T
P
R
F
E
W
F
A
I
--------------
L
T
I
L
P
A
A
L
V
V
I
A
E
------
H
V
G
------
H
L
V
V
T
A
---------
N
I
V
----------
K
K
-----
D
L
L
--
R
D
P
-
G
L
H
R
S
M
F
---------
A
N
G
L
---------------
S
T
V
I
S
G
-
F
F
-
G
-
S
--
T
P
----------
N
---------
T
T
Y
G
E
N
I
----
G
V
M
A
----
I
T
--
R
V
Y
-
S
T
W
----
V
I
------
G
G
A
A
I
F
A
I
L
L
S
C
V
G
---
K
L
A
A
A
-
I
Q
M
-
I
P
L
P
V
M
G
---
G
V
------------------------
S
L
L
L
Y
----------------
G
V
-------------------
I
G
A
S
G
I
R
V
L
--
I
E
S---
K
--
V
D
Y
N
K
A
Q
N
L
I
-------
L
T
S
V
--------
I
L
I
--------
I
G
V
S
-------------------------------------------------------------------------------
G
A
K
-----------------------
V
N
I
G
---------------
A
A
E
L
K
G
M
----------
A
L
A
T
I
V
G
I
G
L
---
S
L
I
F
K
-----
L
I
S
-------------------------------------------------------------------------------
20
Fugue
86.49
16%
-101
- C2 -
3VSM
1
OE66_NPVAC
A:
[27-659]
----------N
I
Q
E
L
Q
N
F
E
R
W
F
K
N
N
L
S
Y
S
F
S
Q
K
A
E
K
V
V
--
N
P
N
R
N
----------------------
W
N
D
N
T
V
----
F
D
N
L
S
-----
P
W
-
T
S
-------------------------------------------------------------------------------------
V
P
D
F
G
T
V
C
H
T
L
I
G
Y
C
V
R
Y
N
N
-----------------------------------
T
S
-
D
-------
T
L
Y
Q
-------
N
P
E
L
A
Y
N
L
I
N
G
L
R
I
I
---
C
S
K
L
P
D
P
P
P
H
Q
-----
Q
A
---
P
W
G
P
V
A
------
D
W
Y
H
F
T
I
T
M
P
E
V
----------------
F
M
N
I
--------
T
I
V
L
N
E
T
Q
H
Y
D
E
---
A
A
---------
S
L
T
R
Y
W
L
G
L
Y
----------
L
P
T
A
V
N
S
M
G
W
H
R
T
A
G
N
S
M
R
------
M
G
-----------
V
P
Y
T
Y
S
Q
M
L
R
G
Y
S
L
A
Q
I
R
---------
Q
E
Q
G
I
Q
E
I
L
N
T
I
AF
P
Y
V
T
---
Q
----
G
N
G
L
H
V
D
S
I
Y
I
D
HID
V
R
A
Y
G
Y
L
I
N
S
Y
F
T
F
A
Y
Y
T
Y
Y
F
G
D
E
V
I
N
------------
T
V
G
L
T
R
A
I
E
N
V
G
S
P
E
G
V
V
V
P
G
V
MSRNGTLYS
N
V
I
G
N
F
I
T
Y
P
L
A
V
H
S
A
D
Y
S
K
V
--------------
L
T
K
L
S
K
T
Y
Y
G
S
V
V
------
G
V
T
------
N
R
L
A
Y
Y
---------
E
S
D
----------
P
T
-----
N
N
I
Q
A
P
L
W
-
T
M
A
R
R
I
W
N
RRGRI
I
N
Y
N
A
N
T
---------------
V
S
F
E
S
G
I
I
L
-
Q
S
L
--
N
G
I
M
R
I
P
S
GTT
S
T
---------
Q
S
F
R
P
T
I
----
G
Q
T
A
----
I
A
--
K
T
D
-
T
-----------------
A
G
A
I
L
V
Y
A
K
F
A
---
E
M
N
N
L
Q
F
K
S
-
C
T
L
F
Y
D
H
---
G
M
------------------------
F
Q
L
Y
Y
----------------
N
I
GVEPNSLNN
T
N
G
R
V
I
VLSR
D
T
S
V
N
T
N
D
L
--
S
-----
F
--
E
A
Q
R
I
N
N
N
N
S
-------
S
E
G
---------
T
T
F
--------
N
G
V
V
-
C
H
R
V
P
I
T
N
I
N
V
P
S
L
T
V
R
S
PNSS---------------
V
E
L
V
E
Q
I
I
S
F
Q
--
T
---------
M
Y
T
A
T
A
S
A
C
Y
K
--
L
N
-
V
E
G
H
S
-----------------------
D
S
L
R
A
F
R
V
-
N
S
D
E
N
I
Y
V
N
V
G
N
G
V
K
A
L
-----------
F
N
Y
P
W
V
M
V
K
E
NN
K
V
S
F
M
S
ANED
T
T
I
P
F
S
V
I
M
N
----
S
F
T
S
I
G
E
P
A
L
---
Q
---
Y
S
P
S
N
C
F
V
Y
G
N
-----
G
F
K
L
NNSTF
D
L
Q
F
I
F
E
I
V-----------------
21
Fugue
82.29
17%
-97
- C2 -
4PKF
3
?
A:
[8-864]
K
V
L
E
Y
KG
K
K
L
N
FTPE
D
P
A
E
E
T
I
P
A
D
E
L
H
E
H
L
Q
K
P
S
T
A
R
--
T
K
R
L
K
E
R
CRWKHASAGEFIEKS
V
T
A
G
I
E
R
M
R
Y
L
----
T
E
A
H
K
A
S
EGK
P
E
-
A
I
R
R
A
L
G
L
A
N
V
L
N
K
S
T
L
V
L
Q
E
DEFIVGYHAEDPN
M
F
P
L
Y
PELS
H
M
A
V
Q
D
Y
----------
L
R
SDYSPQP
A
D
E
A
A
A
I
---
N
E
Y
W
K
P
H
S
L
Q
S
K
C
Q
P
Y
F
D
P
A
D
L
G
R
M
Y
Q
V
-----------------------------------
S
S
--
M
----
E
A
P
S
F
A
-------
S
G
Y
N
S
I
V
P
P
Y
E
T
V
L
E
DG
L
L
A
R
I
K
L
A
E
K
H
I
A
E
A
Q
A
D
M
S
TF
P
W
N
G
T
K
-------
G
L
D
N
I
A
K
I
D
N
W
----------------
K
A
M
V
--------
I
A
C
K
A
V
I
S
W
A
R
R
---
Q
G
---------
R
L
C
K
I
V
A
E
N
F
----------
E
T
D
P
K
R
Q
A
E
L
L
E
I
A
D
I
C
Q
R
IPAEPC
K
G
-----------
L
K
D
A
M
Q
A
K
---
F
F
T
F
L
I
C
H
AIE
R
Y
A
S
G
Y
A
Q
--
K
E
D
T
L
L
W
--
P
Y
Y
K
---
A
S
VVD
K
K
F
Q
P
M
S
H
M
D
A
----
V
E
L
V
E
M
E
R
L
K
I
S
E
H
G
A
G
K
S
R
A
Y
R
E
I
F
P
GSN
D
L
F
I
L
T
V
G
G
T
N
A
K
--
G
E
D
A
C
N
D
M
T
D
A
I
L
E
A
A
---------
K
R
I
R
T
A
E
P
--
S
I
V
F
R
Y
S
K
K
N
R
--------------
E
K
T
L
R
W
V
F
E
C
I
R
D
------
G
L
G
YP
S
I
K
H
D
E
I
G
T
E
---------
Q
M
K
E
Y
A
K
F
SLNGN
G
A
-----
T
D
E
--
E
A
H
N
W
V
N
V
L
C
M
---------
S
P
G
I
H
G
RRKTQKTRSE
G
G
G
S
I
F
P
A
K
-
L
L
-
E
I
S
L
N
D
G
----------
Y
---------
D
W
S
Y
A
D
M
QLGP
K
T
G
D
----
L
S
--
S
L
K
-
S
F
E
----
D
V
W
E
A
F
R
K
Q
Y
Q
Y
A
I
N
L
C
I
S
T
K
D
---
V
S
R
Y
F
-
E
Q
R
F
L
Q
M
P
F
V
S
---
A
I
D
D
G
C
M
E
L
GMDACALSE
Q
P
N
G
W
H
N
P
I
T
T
I
V
----------------
A
A
-------------------
N
S
L
V
A
I
K
K
L
--
V
-----
F
--
E
E
K
K
Y
T
L
E
Q
L
-------
S
Q
A
L
K
A
N
WEGF
E
E
M
R
--------
V
D
F
K
-
R
A
P
K
W
G
N
D
D
D
Y
A
D
G
I
I
T
R
-------------------
F
Y
E
E
I
I
G
G
E
M
R
--
K
ITNYSG
G
P
V
M
P
T
G
Q
A
V
G
L
Y
M
--
E
V
G
S
R
T
G
P
TPDGRFGGEAADDGGISPYMGTD
K
K
G
P
T
A
V
L
-
R
S
V
S
K
V
Q
K
N
Q
K
G
N
L
L
N
Q
----------
R
L
S
V
P
I
M
R
S
K
H
G
-
F
E
I
W
N
-----
S
Y
I
K
T
W
H
D
L
N
ID
H
V
Q
F
N
V
V
S
T
D
E
M
R
A
A
Q
---
R
E
P
E
K
H
H
D
L
I
V
R
V
S
GY
S
A
R
F
VDIP
T
Y
G
Q
N
T
I
I
A
RQE
Q
D
F
S
A
S
D
L
E
F
L
NVEI
26
Fugue
67.79
17%
-112
- C2 -
4LL8
-
A:
[99-536]
---------------
E
R
A
A
A
Q
S
S
L
I
Q
S
H
M
Q
S
L
A
A
N
K
P
S
--
R
L
S
D
E
----------------------
V
K
S
M
K
Q
E
L
A
F
I
E
N
V
I
-----
A
Q
-
A
-----
N
K
P
K
L
V
N
V
I
R
R
E
S
--------------------------
G
N
P
D
L
----------
L
-----------
E
L
L
M
-----
D
L
N
S
Y
T
L
E
V
T
E
G
Y
L
K
K
-
V
N
V
T
E
V
N
G
D
-----------------------------------
N
V
------------
L
-------
G
P
I
H
V
I
T
T
V
V
S
S
L
V
R
---
N
---------------
G
L
---
L
I
Q
S
S
K
------
F
I
S
K
V
L
L
T
V
E
S
I
----------------
V
M
S
L
--------
P
K
D
E
T
M
L
G
-------------------
G
I
F
W
L
S
N
L
S
----------
R
L
P
A
F
A
A
N
Q
K
T
L
Y
E
A
N
G
G
D
------
E
K
-----------
D
----------------------------------------------------
K
L
T
L
I
Y
L
N
D
L
E
----
N
E
T
L
K
V
F
D
K
I
Y
S
T
W
L
V
K
F
M
K
H
A
S
A
H
I
-----------------------------
E
I
F
D
M
V
---------
L
N
E
K
--------
L
F
K
N
S
G
D
E
K
--------------
F
A
K
L
F
T
F
L
N
E
F
D
A
------
V
L
S
------
K
F
Q
V
-------------------------------------
V
D
-
S
M
H
T
K
I
F
---------
N
D
T
L
---------------
K
Y
L
N
V
M
-
L
F
-
N
D
---------------
L
---------
I
T
K
S
P
A
L
----
N
-----------------------
W
------
K
Y
G
Y
E
V
D
R
N
I
E
R
L
V
---
S
W
---------
F
E
P
R
I
E
---
D
V
------------------------
R
P
N
L
I
----------------
Q
I
-------------------
I
Q
A
V
K
I
L
Q
L
--
K
-----
I
------
S
N
L
N
E
F
-------
K
L
L
F
--------
D
F
W
--------
Y
A
L
N
--------------------------------------
P
A
Q
I
Q
A
I
L
L
K
Y
--
K
---------
P
A
N
K
G
-----------
E
A
G
V
P
-----------------------
N
E
--
I
L
N
Y
-
L
A
N
V
I
K
R
E
N
L
S
-----------------
L
P
G
K
M
E
I
M
L
---
S
A
Q
F
D
-----
S
A
-------
K
----
N
H
L
R
Y
D
T
S
A
I
T
Q
N
S
---
N
T
-
E
G
L
A
T
V
S
K
-----
I
I
K
L
-------------------------------
23
Fugue
67.38
13%
-110
- C2 -
2YIC
2
KGD_MYCS2
A:
[7-868]
-------------K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
--
R
L
D
N
T
----------------------
R
F
R
S
T
L
----
W
D
L
D
R
-----
E
F
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
--------------------------
G
V
E
Y
T
HILE
P
E
Q
Q
R
W
I
-----------
Q
E
R
V
E
TK
H
D
K
P
T
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
VGQKRFSLEGAET
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
GLD
E
V
V
I
-
A
M
P
HRG
R
L
N
V
L
A
NIVGKP
Y
S
Q
I
F
S
E
F
E
D
V
K
Y
H
L
G
---
A
T
G
T
Y
I
Q
M
F
G
D
N
D
I
E
V
S
L
---
T
A
N
P
S
H
LEAV
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
DTGEEGSDNRFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
---
R
G
YRTG
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
APTDSRSSEY
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
--------------------
D
P
E
A
C
A
W
V
---
A
R
L
A
V
D
F
---------
R
Q
A
F
K
K
D
V
V
I
D
M
--
L
C
Y
R
RRG
H
----
N
E
G
D
D
P
S
M
T
Q
P
----
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
------------
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
V
---------
R
E
L
E
K
H
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
ALPEGFTVH
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
EGRID
W
A
F
A
------
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
----------
G
Q
DTQRG
T
F
T
--
Q
R
H
-
A
V
I
V
D
R
K
---------
T
G
E
E
---------------
F
T
P
L
Q
L
-
L
A
-
T
N
P
--
D
G
----------
T
PTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
----
A
A
V
G
----
F
E
--
Y
G
Y
-
S
V
G
NPDA
M
V
------
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
---
S
I
I
D
E
-
F
I
S
-
S
G
E
A
K
W
G
QLS
D
V
------------------------
V
L
L
L
P
H
G
H
EGQGPDHTSGR
I
E
R
F
-------------------
L
Q
L
W
A
E
G
S
M
--
T
-----
I
--
A
M
P
S
T
P
A
N
Y
F
-------
H
L
L
R
--------
R
H
G
K
DGIQ
R
P
L
I
V
F
T
-
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
ESKFRSVLEEPMYTDGEGD
R
N
K
V
T
R
L
L
L
T
S
---------------
G
K
I
Y
Y
E
L
A
--
A
R
K
A
K
E
N
R
-----------------------
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
PNVKEKFWVQ
E
E
P
A
N
Q
G
A
W
P
---
S
F
G
L
T
-----
L
P
E
I
L
P
D
H
F
T
----
G
L
K
R
I
S
R
R
A
M
S
A
P
S
SGS
S
K
V
H
A
V
E
Q
Q
E
I
-----
L
D
T
A
F
G-----------------------------
1
PsiBlast_PDB
44.05
29%
-66
- C3 -
3QE7
2
URAA_ECOLI
A:
[227-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
--------------
L
T
I
L
P
A
A
L
V
V
I
A
E
------
H
V
G
------
H
L
V
V
T
A
---------
N
I
V
----------
K
K
-----
D
L
L
--
R
D
P
-
G
L
H
R
S
M
F
---------
A
N
G
L
---------------
S
T
V
I
S
G
-
F
F
-
G
S
---
T
P
----------
N
---------
T
T
Y
G
E
N
I
----
G
V
M
A
----
I
T
--
R
V
Y
-
S
T
W
----
V
I
------
G
G
A
A
I
F
A
I
L
L
S
C
V
G
---
K
L
A
A
A
-
I
Q
M
-
I
P
L
P
V
M
G
---
G
V
------------------------
S
L
L
L
Y
----------------
G
V
-------------------
I
G
A
S
G
I
R
V
L
I
E
S
-----
K
--
V
D
Y
N
K
A
Q
N
L
I
-------
L
T
S
V
--------
I
L
I
--------
I
G
V
S
-
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
-------------------
I
V
G
I
G
L
S
L
I
F
K
--
L
---------
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.02
30%
-59
- C3 -
3SD9
-
?
A:
[103-208]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
G
S
I
V
N
F
T
R
Q
G
N
N
---
K
Y
P
N
L
-
E
K
S
-
L
P
D
T
V
F
P
---
G
D
------------------------
F
N
L
Q
N
----------------
G
S
-------------------
I
R
A
M
Y
L
G
E
A
--
H
TK
D
G
I
F
--
V
Y
F
P
A
E
R
V
L
Y
GNCILKE
N
L
G
N
--------
M
S
F
--------
A
N
R
T
E
Y
P
K
T
L
E
K
L
K
G
L
I
E
Q
G
E
L
K
-------------------
V
D
S
I
I
A
G
H
D
T
P
--
I
---------
H
D
V
G
L
I
D
H
Y
L
T
--
L
L
E
K
A
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.28
30%
-65
- C3 -
3Q6V
1
?
A:
[103-208]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
G
S
I
V
N
F
T
R
Q
G
N
N
---
K
Y
P
N
L
-
E
K
S
-
L
P
D
T
V
F
P
---
G
D
------------------------
F
N
L
Q
N
----------------
G
S
-------------------
I
R
A
M
Y
L
G
E
A
--
H
TK
D
G
I
F
--
V
Y
F
P
A
E
R
V
L
Y
GNCILKE
N
L
G
N
--------
M
S
F
--------
A
N
R
T
E
Y
P
K
T
L
E
K
L
K
G
L
I
E
Q
G
E
L
K
-------------------
V
D
S
I
I
A
G
H
D
T
P
--
I
---------
H
D
V
G
L
I
D
H
Y
L
T
--
L
L
E
K
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
37.76
15%
343
* C3 *
3V4Y
-
PP1R8_HUMAN
B:
[6-60]
------------------
E
T
E
L
D
N
L
T
E
F
N
T
A
H
N
K
R
I
S
T
LT
I
E
E
S
R
----------------------
V
T
F
S
E
D
----
D
E
I
I
N
-----
P
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.06
32%
75
- C4 -
4XK8
-
?
G:
[1-69]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------
L
S
P
S
L
V
I
S
L
S
T
G
L
S
---------
L
F
L
G
R
F
V
F
F
N
F
Q
R
E
N
V
A
K
Q
V
P
-----------------------
E
Q
N
G
L
T
H
F
-
E
A
G
D
T
R
A
K
E
Y
V
S
L
L
K
S
N
----------
D
-
P
V
G
F
N
I
V
D
---
V
L
A
W
G
-----
S
I
G
H
I
V
A
Y
Y
I
----
L
A
T
T
S
N
G
Y
D
P
----------------------------------------------------------
8
PsiBlast_PDB
31.66
33%
86
* C4 *
3LW5
-
PSAG_PEA
G:
[3-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
S
L
S
T
G
L
S
---------
L
F
L
G
R
F
V
F
F
N
F
QR
E
N
V
A
K
Q
V
P
-----------------------
E
Q
N
G
L
T
H
F
-
E
A
G
D
T
R
A
K
E
Y
V
S
L
L
K
S
N
----------
D
-
P
V
G
F
N
I
V
D
---
V
L
A
W
G
-----
S
I
G
H
V
V
A
Y
Y
I
----
L
A
T
T
S
N
G
Y
D
P
A
F
F
-------------------------------------------------------
4
PsiBlast_PDB
31.36
31%
87
- C4 -
2WSC
-
PSAG_SPIOL
G:
[73-138]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
V
I
S
L
S
T
G
L
S
---------
L
F
L
G
R
F
V
F
F
N
F
QR
E
N
M
A
K
Q
V
P
-----------------------
E
Q
N
G
M
S
H
F
-
E
A
G
D
T
R
A
K
E
Y
V
S
L
L
K
S
N
----------
D
-
P
V
G
F
N
I
V
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
30.70
31%
83
- C4 -
2WSE
-
PSAG_SPIOL
G:
[4-69]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
V
I
S
L
S
T
GL
S
---------
L
F
L
G
R
F
V
F
F
N
F
QR
E
N
M
A
K
Q
V
P
-----------------------
E
Q
N
G
M
S
H
F
-
E
A
G
D
T
R
A
K
E
Y
V
S
L
L
K
S
N
----------
D
-
P
V
G
F
N
I
V
D
---
V
L
A
W
G
-----
S
I
G
H
I
V
A
Y
Y
I
----
L
A
T
A
S
N
G
Y
D
P
S
F
F
-------------------------------------------------------
6
PsiBlast_PDB
30.63
31%
95
- C4 -
2WSF
-
PSAG_SPIOL
G:
[73-138]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
V
I
S
L
S
T
G
L
S
---------
L
F
L
G
R
F
V
F
F
N
F
QR
E
N
M
A
K
Q
V
P
-----------------------
E
Q
N
G
M
S
H
F
-
E
A
G
D
T
R
A
K
E
Y
V
S
L
L
K
S
N
----------
D
-
P
V
G
F
N
I
V
------------------------------------------------------------------------------------------------
28
Fugue
30.01
30%
449
* C2 *
1WNM
-
?
A:
[1-23]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
P
-----------------------
E
Q
R
A
T
R
L
K
-
R
M
S
E
Y
A
A
K
R
L
S
S
------------------------------------------------------------------------------------------------------------------------
11
HHSearch
27.22
25%
233
- C3 -
2FIP
-
VG4_BPPH2
A:
[64-99]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
A
--
D
I
T
F
Y
S
E
V
-----------------------
E
K
R
G
F
H
A
W
-
L
K
G
D
N
A
T
---
W
R
E
V
H
V
Y
----------
A
L
R
I
M
T
K
P
N
T
---
L
D
W
S
R
-----
I
Q
K
P
R
-----------------------------------------------------------------------------
10
HHSearch
24.90
8%
-31
- C3 -
3QE7
2
URAA_ECOLI
A:
[45-144]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
L
L
---------
F
N
G
I
---------------
G
T
L
L
Y
L
-
F
I
C
K
G
K
--
I
P
----------
A
---------
Y
L
-
G
S
S
F
----
A
F
I
S
P
V
L
L
L
L
PL
G
Y
E
V
A
L
G
----
G
F
------
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
-
D
V
L
-
F
P
P
A
A
M
G
---
A
I
------------------------
V
A
V
I
G
----------------
L
E
-------------------
L
A
G
V
A
A
G
M
A
--
G
-----
L
--
L
P
A
E
G
Q
T
P
D
S
-------
K
T
I
I
--------
I
S
I
--------
T
T
L
A
-
V
T
V
L
G
S
V
L
F
R
G
F
L
A
I
I
P
I
-------------------
L
I
G
V
L
V
G
Y
A
L
S
--
F
---------
A
M
G
I
V
D
T
T
P
I
I
--
N
A
H
W
F
A
L
P
-----------------------
T
L
Y
T
P
R
F
E
-
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
----------
H
V
G
H
L
V
V
T
A
N
---
I
V
K
K
D
-----
L
L
R
D
P
G
L
H
R
S
----
M
F
A
N
G
L
S
T
V
I
S
G
F
F
---
G
S
T
P
N
T
T
Y
G
E
N
-----
I
G
V
M
-------------------------------
15
HHSearch
24.84
28%
9
- C3 -
3WU2
-
PSBZ_THEVL
Z:
[17-52]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------------
V
M
-------------------
V
I
G
V
P
V
A
Y
A
--
S
-----
P
--
Q
D
W
D
R
S
K
Q
L
I
-------
F
L
G
S
--------
G
L
W
--------
I
A
L
V
-
L
V
V
G
V
L
N
F
F
V
V
A
R
R
T
W
L
G
-------------------
D
I
L
R
P
L
N
S
E
Y
G
--
K
---------
V
A
P
G
W
G
T
T
P
L
M
--
A
V
F
M
G
L
F
L
-----------------------
V
F
L
L
I
I
L
E
-
I
Y
N
S
T
L
I
L
D
G
V
N
V
S
W
K
A
-------------------------------------------------------------------------------------------------------------------
17
HHSearch
22.48
21%
464
- C3 -
1FDM
-
CAPSD_BPFD
A:
[27-45]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
V
----------
V
V
I
V
G
A
T
I
G
I
K
L
F
K
K
F
T
S
K
------
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------