@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S23A2_HUMAN: (2015-12-09 )
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG
Atome Classification :
(18 SA)
-------------.........10........20......-..30........40.......-.50.......---.60.......--.70........80........90........100-.........110....-.....120.....---..130--.....--....140.......-------150......-.--160.......170.......180.-......190.......200.......210.....------..220.......230----.......240.......250.......260.....-----------..-270.......280....-----...290.......300....------...310.......320.......330.......340.......350.......360.......370.......380.......-390.......400....-...410...--....420-.......430.-.......440.......----450---.......--460.......470..---....--.480....--...490.......500-....--.--.--.510.......520.......-530.........540...-....550....--------...560.......570........580.......590.......600.......610.......620--.......630.......640.......650--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MMGIGKNTTSKSMEAGSSTEGKYEDEA-KH
P
A
F
F
T
L
P
V
V
I
NGGATSSGE-QDNEDT
E
L
M
A
---
I
Y
TTENGIA
E
--
K
S
S
L
A
E
T
L
D
STGSLDPQRS
D
M
I
Y
T
IEDV
P
P
W
Y
---
L
C
I
F
L
G
L
Q
H
Y
--
L
T
C
F-SG
T
I
A
V
P
F
L
L
A
D
A
---
M
CV----G
Y
D
Q
W
--
A
T
S
Q
L
I
G
T
I
F
F
C
V
G
-------
I
T
T
L
L
Q
T
TF-G--CRLPLFQA
S
A
F
A
F
L
A
P
A
R
A
I
L
S
LD-KWKCNTT
D
V
SVANG
T
A
E
L
LHTEHIW
Y
P
R
I
R
E
I
Q
G
------
A
I
I
M
S
S
L
I
E
V
V
I
G
L
L----GL
P
G
A
L
L
K
YIGPLTIT
P
T
V
A
L
IGLS
G
F
Q
A
A
G
E
RAG-----------K
H
-
W
G
I
A
M
L
T
I
F
L
V
L
L
F
S
Q
Y
-----ARNVKFPLPIYKSKKG
W
T
A
Y
------
K
L
Q
L
F
K
M
F
P
I
I
L
A
I
L
V
S
W
L
L
C
F
I
F
T
V
T
DVFPPDSTK
Y
G
F
Y
A
RTDARQ
G
V
L
L
VAPWFKVPYPFQWGLPT
V
S
A
A
G
V
I
G
M
L
S
A
V
V
A
-
S
I
I
E
S
I
G
D
Y
Y
A
C
ARLSC-APPP
P
I
H
A
I--NR
G
I
F
V
E
-
G
L
S
C
V
L
D
G
-IF-GTGNGSTSSSP
N
I
G
V
L
G
----
I
TK---VGS
R
R
V
I
--
Q
C
G
A
A
L
M
L
A
L
G
M
I
G
K
---
F
S
A
L
--
F
ASLP
D
P
V
--
L
G
A
L
F
C
T
L
F
G
M
I
T
A
VG-LS
N
L
--
Q
--
F
--
I
DLNSSR
N
L
F
V
L
G
F
S
I
F
F
G
L
V
-
L
--
P
S
Y
L
RQNPLVT
G
I
T
G
-
I
D
Q
V
L
N
V
L
L
T
T
--------
A
M
F
V
G
G
C
V
A
F
I
LDN-TIPGT
P
E
E
R
G
I
R
K
W
K
K
GVGKGNKSLDG
M
E
SYNLP
F
G
M
N
I
I
K
K
YRC
F
S
YLPIS--
P
T
F
V
G
Y
T
W
KGLRKSDNSRSSDEDSQATG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
96.09
27%
-130
- C7 -
3QE7
2
URAA_ECOLI
A:
[4-410]
------------------------------------------------------------------------------------------------------------
R
A
I
G
V
S
E
R
P
P
L
L
---
Q
T
I
P
L
S
L
Q
H
L
--
F
A
M
F
-
G
A
T
V
L
V
P
V
L
F
H
-------
I
----
N
-----------
P
A
T
V
L
L
F
N
G
-------
I
G
T
L
L
Y
L
F
I
C
K
--
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
-----------------------------
L
G
Y
E
V
A
L
G
------
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
-
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
LLPAEGQTPD
S
K
T
-
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
-----
F
R
G
F
--------------------------
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
------------------
T
P
I
I
N
A
H
W
F
A
L
P
T
L
Y
---
T
P
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
-
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
-
K
D
L
L
R
D
P
G
L
--
H
R
S
M
F
A
N
-
G
L
S
T
V
I
S
G
-
F
F
-
G
S
T
P
-
N
T
T
Y
G
E
N
I
G
V
M
A
----
I
T
R
---
V
Y
S
T
W
V
I
--
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
---
L
A
A
A
--
I
Q
M
I
P
L
P
V
--
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
-
I
R
V
L
--
I
--
E
SK
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
-
G
--
A
K
V
N
I
----------------
G
A
A
E
L
K
--------
G
M
A
L
A
T
I
V
G
I
G
L
S
L
-
I
F
K
L
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
88.39
24%
-109
- C7 -
3QE7
2
URAA_ECOLI
A:
[4-410]
------------------------------------------------------------------------------------------------------------
R
A
I
G
V
S
E
R
P
P
L
L
---
Q
T
I
P
L
S
L
Q
H
L
--
F
A
M
F
-
G
A
T
V
L
V
P
V
L
F
H
--------------------
I
N
P
A
T
V
L
L
F
N
G
I
G
-------
T
L
L
Y
L
F
I
C
K
-
G
---
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
L
G
-
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
------
P
P
A
A
M
G
A
I
V
A
V
I
G
L
-----
E
L
A
G
V
A
A
G
M
A
G
L
L
P
-------------
A
E
G
Q
T
P
D
S
-----------
K
T
-
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
-----
F
R
G
--------------------------
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
------------------
A
H
W
F
A
L
P
T
L
Y
T
---
P
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
-
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
-
K
D
L
L
R
D
P
G
L
--
H
R
S
M
F
A
N
-
G
L
S
T
V
I
S
G
-
F
F
-
G
-
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
----
I
T
R
---
V
Y
S
T
W
V
I
--
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
---
L
A
A
A
--
I
Q
M
I
P
L
P
V
--
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
-
I
R
V
L
--
I
E
S
K
--
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
----
G
A
K
V
N
I
G
A
A
E
L
K
G
M
A
-
L
A
T
I
V
G
I
G
L
S
L
--------
I
F
K
L
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
77.52
20%
-72
- C6 -
4TQT
6
?
A:
[14-490]
---------------------
A
S
K
V
I
K
G
G
T
V
I
T
A
D
R
T
F
R
A
---------
D
I
L
I
E
D
G
K
I
A
A
I
G
-
D
S
L
E
G
D
E
V
I
D
ASG
C
Y
V
M
P
G
G
I
D
P
--
H
T
H
L
Q
M
P
F
M
G
T
Y
S
S
D
-----------
D
F
D
T
G
T
---
A
A
A
L
A
G
-----------
G
T
T
M
V
V
D
F
V
L
P
D
S
EGN
L
L
D
----
A
L
Q
E
W
F
Q
K
A
G
K
A
R
T
D
Y
S
F
H
M
A
-------
I
T
G
W
N
E
R
T
F
-
N
E
M
A
E
V
V
K
R
G
I
N
T
F
H
F
M
A
Y
K
G
A
L
M
V
N
D
-
D
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
M
P
L
V
H
A
E
N
----------
G
------
D
I
V
A
Q
L
Q
A
K
L
M
A
E
G
N
----
D
G
P
E
A
H
A
Y
-----
S
R
P
P
E
V
E
G
E
A
T
N
R
A
I
M
I
A
D
Q
A
G
-------------------
V
P
L
Y
V
V
H
V
--------------------------------------------------------------------
S
C
E
Q
S
H
E
A
I
R
R
A
R
Q
K
G
M
-----------------
R
V
F
G
E
P
L
I
Q
H
L
T
-
L
D
E
-
S
E
Y
H
N
R
D
W
D
Y
A
A
R
R
V
---
M
S
P
P
F
R
D
K
L
--
N
Q
D
S
L
W
A
-
G
L
A
A
------------------------------------
G
S
---
L
--
Q
C
V
A
T
D
H
C
A
F
T
T
E
Q
K
---
R
Y
G
I
GN
F
T
K
I
P
N
G
T
G
G
L
E
E
R
M
P
V
L
W
T
R
G
V
R
T
G
R
L
T
P
N
--
E
--
F
--
V
A
V
T
S
T
N
I
A
K
I
L
N
I
Y
P
Q
K
G
A
V
-
V
--
P
G
A
-----------
D
-
A
D
L
V
I
W
D
P
E
T
T
--------
K
K
I
S
A
K
T
Q
H
S
S
I
D
Y
-
N
V
F
E
G
F
E
L
K
G
L
P
I
M
--
T
L
S
R
G
R
I
A
F
D
K
G
Q
V
T
A
K
P
G
D
G
R
F
I
E
R
E
P
N
-------------
G
A
V
N
R
A
L
S
Q
W
K
E
I
V
A
P
R
K
V
E
R
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
62.34
9%
-84
- C8 -
4B8B
-
NOT1_YEAST
A:
[42-596]
-----------------------------------------------------------
L
E
G
-
E
S
L
N
D
L
L
A
L
L
---
L
S
E
I
L
S
A
T
N
R
--
G
N
V
I
A
R
S
I
S
S
L
Q
A
N
Q
I
N
W
N
R
V
F
N
L
M
S
T
------------------------------------
K
Y
---
F
L
L
----
M
P
T
T
A
--
S
L
S
C
L
F
A
A
L
H
D
G
P
V
-------
I
D
E
F
F
S
C
D
W
-
K
--
V
I
F
K
L
D
L
A
I
Q
L
H
K
W
S
V
Q
N
G
C
F
D
L
L
-
N
----
A
E
G
T
R
K
V
S
E
T
I
P
N
T
K
Q
S
L
L
Y
L
L
S
I
A
S
L
N
L
------
E
L
F
L
Q
R
E
E
L
S
D
G
P
M
L
----
A
Y
F
Q
E
C
F
F
E
--
D
F
N
Y
A
P
E
Y
L
I
L
A
L
V
K
E
M
K
R
F
V
L
L
I
-----------
E
N
--
R
T
V
I
D
E
I
L
I
T
L
L
I
Q
V
H
-----
N
K
S
-----------------------
P
S
S
F
K
D
V
I
S
T
-----
I
T
D
D
S
K
I
V
D
A
A
K
I
I
I
N
S
D
D
A
P
I
A
N
F
L
K
S
L
L
D
T
G
R
-
L
D
T
V
I
N
K
L
P
F
N
E
A
F
K
I
L
P
C
A
R
Q
I
G
W
E
G
F
D
T
F
L
K
-
T
K
V
S
P
S
N
V
D
V
V
L
E
S
L
E
V
-
Q
T
K
M
T
D
T
P
F
RS
L
K
T
F
D
L
F
-
A
F
H
S
L
I
E
V
-
L
N
-
K
C
P
L
D
V
L
Q
L
Q
R
F
E
S
L
E
F
----
S
L
L
---
I
A
F
P
R
L
I
--
N
F
G
F
G
H
D
E
A
I
L
A
N
G
D
---
I
A
G
I
--
N
N
D
I
E
K
E
M
--
Q
N
Y
L
Q
K
M
Y
S
G
E
L
A
I
K
D
-
V
I
E
L
--
L
--
R
--
R
L
R
D
S
D
L
P
R
D
Q
E
V
F
T
C
I
T
H
A
V
-
I
--
A
E
S
T
F
F
Q
D
Y
P
----------
L
D
A
L
A
T
T
--------
S
V
L
F
G
S
M
I
L
F
Q
L
----
L
R
G
F
V
L
D
V
A
F
R
I
I
M
R
F
A
K
E
P
P
------
E
S
K
M
F
K
F
A
V
Q
A
I
Y
A
F
R
--
I
R
L
A
E
Y
--
P
Q
Y
C
K
D
L
L
R
D
V
P
A
L
K
S
Q
A
Q
V
Y
Q
S
I
V
E
A
A
T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
59.97
17%
-85
- C7 -
4C0E
-
?
A:
[9-528]
-------------------------------
L
E
A
A
H
L
L
E
Q
M
E
Y
V
F
D
E
W
I
H
L
C
N
N
P
H
A
T
E
R
A
A
M
I
F
V
H
Q
L
H
S
V
Q
---
L
V
T
N
R
D
E
F
L
L
F
L
R
H
A
L
D
K
S
V
E
R
F
E
Q
G
I
H
S
G
A
S
I
A
E
S
F
Q
A
V
E
A
L
V
---
K
L
I
I
I
F
V
K
S
H
S
A
A
V
A
F
M
D
S
I
L
A
L
G
V
L
V
A
N
S
---
H
H
V
K
RGE
N
F
N
Q
R
--
V
F
Y
R
F
F
A
L
L
L
H
E
V
G
-------
L
L
A
-------------
G
H
F
S
K
S
H
Y
E
Q
I
I
L
N
F
A
A
R
L
F
D
M
R
---
P
N
L
L
P
G
F
A
C
A
W
A
G
L
V
-
S
H
R
A
F
L
P
V
I
L
G
L
P
D
------
E
K
G
W
A
P
F
T
K
L
L
E
Q
F
L
----
G
C
V
G
E
L
V
K
T
F
T
V
-------------------
S
S
L
G
-----------
K
E
M
Y
-
H
A
A
L
K
I
L
I
V
L
Q
H
D
------------
F
P
I
Y
L
D
K
-------
F
------
R
V
Q
L
C
Q
S
L
P
L
H
A
T
Q
L
V
N
L
I
L
-------
A
A
I
P
P
N
C
N
S
---------------------
L
A
D
P
F
Q
A
G
L
K
V
----------------------------
D
K
I
P
D
M
K
E
R
P
P
T
A
F
D
--
S
A
G
L
L
R
E
A
G
L
L
D
I
L
E
R
M
L
----
Q
N
G
P
S
E
D
G
V
A
Q
I
N
H
A
----
I
N
K
---
S
T
S
F
G
Y
V
--
P
L
G
V
N
R
R
L
I
D
A
V
V
A
R
---
F
A
E
F
--
A
I
N
R
A
S
S
-----------------------------------
R
S
D
S
A
I
F
V
A
G
A
N
D
I
K
T
L
Q
M
L
--
V
T
E
V
S
P
E
A
R
Y
Y
L
V
S
S
M
V
N
E
L
R
Y
P
N
A
Y
T
--------
N
Y
F
S
Q
A
L
L
D
I
F
G
H
D
M
S
---
D
P
E
E
N
L
V
R
E
Q
I
V
R
V
L
L
E
R
V
L
G
Y
W
P
Q
P
W
G
L
I
I
T
I
L
E
L
L
K
N
D
K
Y
L
F
F
E
L
P
--
F
I
------
K
A
T
P
E
V
A
E
R
F
T
A
L
A
R
S
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
55.33
8%
-82
* C8 *
3GB8
-
XPO1_HUMAN
A:
[53-1061]
LKEHPRVD
T
I
L
E
F
S
Q
N
M
N
T
K
Y
Y
G
L
Q
I
L
E
N
V
I
K
T
R
W
R
N
Q
C
E
-
G
I
K
K
Y
V
V
G
L
I
I
K
T
S
S
E
K
E
K
V
Y
-
I
G
K
L
N
M
I
L
V
Q
---
I
L
K
Q
E
W
P
K
H
W
--
P
T
F
I
S
D
I
V
G
A
S
R
T
S
E
S
L
C
Q
N
N
M
V
I
L
K
L
L
S
E
E
V
---
F
T
Q
V
K
S
K
H
L
K
--
D
S
M
C
-
N
E
F
S
Q
I
F
Q
L
C
Q
F
V
---
M
E
N
----
S
Q
N
A
P
--
L
V
H
A
T
L
E
T
L
L
R
F
L
N
WIPLGYI
F
E
T
K
L
I
S
T
L
-
I
--
Y
K
F
L
N
V
P
M
F
R
N
V
S
L
K
C
L
T
E
I
A
G
V
S
-
V
S
Q
Y
E
E
Q
F
V
T
L
F
T
L
T
M
M
Q
L
K
Q
M
L
P
L
N
T
N
I
R
L
A
Y
S
N
GK
D
D
E
Q
N
F
I
Q
N
L
S
L
F
L
C
T
F
L
----
K
E
H
D
Q
L
I
E
K
R
L
N
L
R
E
T
L
M
E
A
L
H
Y
M
L
L
V
S
E
V
E
E
T
E
I
-----------
F
K
-
I
C
L
E
Y
W
N
H
L
A
A
E
L
Y
R
E
S
PFSVP
P
R
R
Q
L
Y
L
P
M
L
F
K
V
R
L
L
M
V
S
R
MAKPEE
D
T
D
S
I
N
L
Y
K
N
M
R
E
T
L
V
Y
L
T
H
L
D
Y
V
D
T
E
R
I
M
T
E
K
L
H
N
Q
V
N
G
T
E
W
S
W
K
N
L
N
T
L
C
W
A
I
G
S
I
S
G
A
M
H
E
E
D
E
K
R
F
L
V
T
V
I
K
D
L
L
G
L
C
E
Q
K
R
G
K
D
N
K
A
I
I
A
S
N
I
M
Y
I
-
V
G
Q
Y
P
R
F
L
R
--
A
H
W
K
F
L
K
-
T
V
V
N
K
L
F
E
-
F
M
-
H
E
T
H
D
G
V
Q
D
M
A
C
D
T
F
I
K
----
I
A
Q
---
K
C
R
R
H
F
V
QV
Q
V
G
E
V
M
P
F
I
D
E
I
L
N
N
---
I
N
T
I
--
I
C
D
L
Q
P
Q
Q
--
V
H
T
F
Y
E
A
V
G
Y
M
I
G
A
Q
T
-
D
Q
T
V
--
Q
--
E
--
H
L
I
E
K
Y
M
L
L
P
N
Q
V
W
D
S
I
I
Q
Q
A
-
T
K
N
V
D
I
L
K
D
P
E
T
V
K
Q
L
G
S
-
I
L
K
T
N
V
R
A
C
K
A
V
GHPF
V
I
Q
L
G
R
I
Y
L
D
M
L
N
V
Y
K
C
-
L
S
E
N
I
S
A
A
I
Q
A
N
G
E
M
V
T
K
Q
P
L
I
R
S
M
R
T
V
K
R
E
T
L
K
L
I
S
G
W
V
S
R
S
N
D
P
Q
M
V
A
E
N
F
V
P
P
L
L
D
A
V
L
I
D
Y
Q
R
N
V
P
A
A
R
E
P
E
V
L
S
T
M
A
I
I
V
N
K
LGGHITAE
I
P
Q
I
F
D
A
V
F
E
C
T
L
N
M
I
NKDFEEY
P
E
H
R
T
N
F
F
L
L
L
Q
A
V
N
S
HC
F
P
A
F
L
A
IP
P
T
Q
F
K
L
V
L
D
S
I
I
W
A
F
K
HTM
R
N
V
A
D
T
G
L
Q
I
L
F
T
L
L
Q
N
V
A
Q
E
EAA
A
Q
S
F
Y
Q
T
Y
F
C
D
I
L
Q
H
I
F
S
V
V
T
DTSHTAG
L
T
M
H
A
S
I
L
A
Y
M
F
N
L
V
E
E
GKISTSLNPGNPVN
N
Q
I
F
L
Q
E
Y
V
A
N
L
L
K
S
A
F
PHLQ
D
A
Q
V
K
L
F
V
T
G
L
F
S
L
NQDI
P
A
F
K
E
H
L
R
D
F
L
V
Q
I
K
E
F
AGED
T
S
D
L
F
L
E
E
R
E
I
A
L
R
Q
A
D
E
E
K
H
K
R
Q
M
S
VPGIFN
1
PsiBlast_PDB
52.98
26%
-103
- C7 -
3QE7
2
URAA_ECOLI
A:
[180-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
------------------
I
I
N
A
H
W
F
A
L
P
T
L
Y
T
---
P
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
-
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
-
K
D
L
L
R
D
P
G
L
--
H
R
S
M
F
A
N
-
G
L
S
T
V
I
S
G
-
F
F
-
G
S
-
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
----
I
T
R
---
V
Y
S
T
W
V
I
--
G
G
A
A
I
F
A
I
L
L
S
C
V
G
K
---
L
A
A
A
--
I
Q
M
I
P
L
P
V
--
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
-
I
R
V
L
I
E
S
--
K
--
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
-
G
--
A
K
V
N
I
G
A
A
E
L
K
G
M
A
L
-
A
T
I
V
G
I
G
L
S
L
I
--------
F
K
L
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
34.34
27%
162
- C5 -
3PQI
-
?
A:
[31-74]
-------------
V
I
G
V
D
Y
G
S
K
T
V
T
L
E
S
I
V
K
N
T
-----
E
I
-
D
Y
P
T
F
H
D
V
P
F
M
V
N
G
G
G
T
G
R
I
S
-
F
P
I
K
A
G
D
I
G
V
---
V
V
F
S
S
S
G
T
L
I
--
Q
P
C
G
L
Y
P
A
C
F
I
P
K
I
A
T
A
T
D
S
S
E
E
V
D
S
E
K
V
I
I
S
---
N
N
K
Q
T
Y
A
S
F
D
--
P
N
G
N
-
I
S
V
Y
N
T
Q
G
M
K
I
D
M
---
T
P
N
----
S
I
V
L
T
--
D
A
G
G
G
K
L
T
L
Q
G
G
T
M
-------
T
Y
K
G
G
T
V
N
L
-
N
--
G
L
T
I
T
P
D
G
R
M
T
D
S
G
G
I
G
L
H
T
H
T
H
P
-
V
R
G
V
E
T
G
G
S
T
V
T
S
D
K
P
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
31.40
12%
151
- C3 -
2WSC
-
?
N:
[121-161]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
G
S
C
K
F
P
E
N
F
T
G
C
Q
D
L
A
K
Q
K
K
V
P
F
L
--
S
D
D
L
D
L
E
C
E
G
K
D
K
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
28.11
12%
247
* C7 *
4PKY
-
TACC3_MOUSE
B:
[2-50]
-------------------------------------------------------
E
F
E
V
L
A
L
-
Q
A
S
L
R
K
A
Q
M
Q
---
N
H
S
L
E
M
T
L
E
Q
--
K
T
K
E
I
D
E
L
T
R
I
C
D
D
L
I
S
K
M
E
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
27.12
34%
252
- C7 -
1Z65
-
PRND_MOUSE
A:
[1-30]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
R
L
G
-----------
T
--
W
W
V
A
I
L
C
M
L
L
A
S
H
L
S
T
V
K----
A
R
G
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
24.69
11%
-30
- C7 -
3QE7
2
URAA_ECOLI
A:
[45-144]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
L
L
F
N
-
G
I
G
T
L
L
Y
L
-
F
I
C
K
G
K
I
P
A
Y
L
-
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
LG
Y
E
V
A
L
G
G
F
--
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
--
D
V
L
F
P
P
A
A
--
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
-
A
G
M
A
--
G
--
L
--
L
P
A
E
G
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
-
V
--
T
V
L
G
S
V
L
F
R
G
F
L
A
I
I
-
P
I
L
I
G
V
L
V
G
Y
A
--------
L
S
F
A
M
G
I
V
D
T
T
P
I
I
-
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
--
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
23.37
44%
814
- C7 -
1UFZ
-
A:
[1-16]
------------------------------------------------------
G
S
S
G
S
S
G
E
-
Y
G
Y
E
D
L
R
E
S
S
---
N
S
L
L
N
H
Q
L
S
E
--
I
D
Q
A
R
L
Y
S
C
L
D
H
M
R
E
V
L
G
D
A
V
P
D
D
I
L
T
E
A
I
L
K
---
H
K
F
D
V
Q
K
A
L
S
--
V
V
L
E
-
Q
D
G
S
G
P
S
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
20.47
26%
413
- C7 -
1HJI
1
VNUN_BPHK0
B:
[1-26]
-----------------------------------------------------
D
R
G
L
T
S
R
D
R
-
R
R
I
A
R
W
E
K
R
I
---
A
Y
A
L
K
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
18.65
15%
175
- C4 -
3A57
-
HLY2_VIBPA
A:
[122-151]
----------------------------------------------------------------------------------------------------------
P
S
K
M
Y
-
L
D
E
T
P
E
Y
F
V
N
V
E
A
Y
E
S
G
S
G
N
I
--
L
V
M
C
-
I
S
N
K
E
S
F
F
E
C
K
H
Q
---
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
17.53
29%
322
- C7 -
2FIP
-
VG4_BPPH2
A:
[65-98]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
D
I
-
T
F
Y
S
E
V
E
K
R
G
F
H
A
W
L
K
G
D
N
A
T
W
---
R
E
V
H
V
Y
A
L
R
I
M
T
K
P
N
T
L
D
W
S
R
I
Q
K
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
16.29
67%
1529
- C1 -
2LOR
-
TM141_HUMAN
A:
[55-63]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
P
Y
P
L
Q
W
S
L
L
V
A
V
V
A
G
S
V
V
S
Y
G
V
T
R
V
-
E
S
E
K
C
N
N
L
W
L
F
L
E
T
G
Q
L
-
P
K
D
R
S
T
D
Q
R
--
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
9.42
23%
941
- C2 -
1DL0
-
TK1C_HADVE
A:
[9-21]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
A
A
C
C
P
C
C
--
P
G
T
S
C
K
A
E
S
N
G
V
S
Y
C
R
K
D
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------