@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2536_HUMAN: (2015-12-09 )
MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------.........10........20.....--...30.......---------.40-...-.....50.......-----------.-60........70...-....-----------.80.....-...90.......-.100.......-----110.--.-----..----...120-----.-------........130--.........140-.......150.-.----....--.--.160....-----...------170.......180---------------------..-----....-..-.190..--------...---.--..200.......-210.......220.......230.....------..-240...-------....250.----.------.....------260---.....-....270-------......----.280--..----------....--.290.......300.----...------...310------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------MSQR
D
T
L
V
H
L
FAGGCGGT
V
G
A
I
L
TC
P
--
L
E
V
V
K
T
R
LQSS
S
---------
V
T
L
-
Y
I
S
-
E
V
Q
L
N
TMAGASVNR-----------V-VSPG
P
L
H
C
L
K
V
I
L
EK-E
G
P
R
-----------
S
L
F
R
GLGP-
N
L
VGVAPS
R
A
I
Y
-
F
A
A
Y
S
N
C
K
E
K
L
-----
N
DVF--D-----PD----ST
Q
V
-------
H
-------
M
I
S
A
A
MAG
F
----
T
A
I
TATN
P
I
W
L
I
-
K
T
R
L
Q
LDAR-N-R----GERR--
M
--
G
A
F
E
C
V
R
K
-----
V
Y
Q------TD
G
L
K
G
F
Y
R
GM-----------------------SA-----SYAG-
I
S
-
E
T
V
-
I
H
--------
F
V
I
---
Y
--
E
S
I
K
Q
K
L
L
E
Y
KT-ASTME
N
D
E
E
S
V
K
E
A
S
D
F
V
G
M
M
L
A
AATSK------T
C
-
A
T
TIAY-------
P
H
E
V
V
R
T
R
----
L
------
R
EE
G
T
------
K
-----
Y
R
S
F
F
-
Q
T
L
S
L
L
V
-------QEEG
Y
G
----
S
L
Y
R
--
G
L
----------
T
T
H
L
--
V
R
QIPN
T
A
I
M
M
A
T
Y
E
----
L
V
V
------
Y
L
LNG-------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
84.95
23%
-61
- C2 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
--
I
E
R
V
K
L
L
L
Q
V
Q
H
---------
A
S
K
-
Q
I
S
-
A
E
K
------------------------
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
-
Q
G
F
L
-----------
S
F
W
R
G
N
L
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
F
K
D
K
Y
K
Q
I
F
L
GGVD
R
H
K
Q
--
F
-----
W
R
----
Y
F
A
G
-------
N
-------
L
A
S
G
G
A
A
G
A
----
T
S
L
C
F
V
Y
P
L
D
F
A
-
R
T
R
L
A
A
D
V
G
-
K
-
G
----
A
A
Q
R
--
E
FT
G
L
G
N
C
I
T
K
-----
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
-----------------------
N
V
-----
S
V
Q
G
-
I
I
-
I
Y
R
A
A
Y
--------
F
G
V
---
Y
--
D
T
A
K
G
M
L
P
D
---------------
P
K
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
------
A
V
-
A
G
L
V
S
Y
-------
P
F
D
T
V
R
R
R
----
M
M
M
Q
SGR
K
G
A
D
I
------
M
-----
Y
T
G
T
V
-
D
C
W
R
K
I
A
-------
K
D
E
G
P
K
----
A
F
F
K
--
G
A
----------
W
S
N
V
--
L
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
----
I
--------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.78
24%
-64
- C2 -
2C3E
4
ADT1_BOVIN
A:
[8-293]
--------------------------------------------------------------------------------------------------------------
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
--
I
E
R
V
K
L
L
L
Q
V
Q
H
---------
A
S
K
-
Q
I
S
A
E
K
Q
Y
K
-------------------------
G
I
I
D
C
V
V
R
I
P
K
E
-
Q
G
F
L
-----------
S
F
W
R
G
N
L
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
----
F
K
D
K
Y
-----
K
Q
I
F
LG
G
-----
V
D
----
R
H
K
Q
F
W
R
Y
F
A
G
N
-------
L
A
S
G
G
A
A
G
A
----
T
S
L
C
F
V
Y
P
L
D
F
A
-
R
T
R
L
A
A
D
V
G
-
K
-
G
----
A
A
Q
R
EF
T
--
G
L
G
N
C
I
T
K
-----
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
-----------------------
N
V
-----
S
V
Q
G
-
I
----
I
-
I
Y
--------
R
A
A
---
Y
--
F
G
V
------
Y
D
T
-
A
K
G
M
L
P
D
P
K
N
V
H
----
I
I
V
S
W
M
I
A
Q
T
V
T
------
A
V
-
A
G
L
V
S
Y
-------
P
F
D
T
V
R
R
R
M
---
M
------
M
Q
S
G
R
------
K
GADIM
Y
T
G
T
V
-
D
C
W
R
K
I
A
-------
K
D
E
G
P
K
----
A
F
F
K
--
G
A
----------
W
S
N
V
--
L
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
----
I
--------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.30
24%
-67
- C2 -
1OKC
10
ADT1_BOVIN
A:
[8-293]
--------------------------------------------------------------------------------------------------------------
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
--
I
E
R
V
K
L
L
L
Q
V
Q
H
---------
A
S
K
-
Q
I
S
A
E
K
Q
Y
K
-------------------------
G
I
I
D
C
V
V
R
I
P
K
E
-
Q
G
F
L
-----------
S
F
W
R
G
N
L
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
----
F
K
D
K
Y
-----
K
Q
I
F
L
G
G
-----
V
D
----
R
H
K
Q
F
W
R
Y
F
A
G
N
-------
L
A
S
G
G
A
A
G
A
----
T
S
L
C
F
V
Y
P
L
D
F
A
-
R
T
R
L
A
A
D
V
G
-
K
-
G
----
A
A
Q
R
EF
T
--
G
L
G
N
C
I
T
K
-----
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
-----------------------
N
V
-----
S
V
Q
G
-
I
----
I
-
I
Y
--------
R
A
A
---
Y
--
F
G
V
------
Y
D
T
-
A
K
G
M
L
P
D
P
K
N
V
H
----
I
I
V
S
W
M
I
A
Q
T
V
T
------
A
V
-
A
G
L
V
S
Y
-------
P
F
D
T
V
R
R
R
M
---
M
------
M
Q
S
G
R
------
K
GADIM
Y
T
G
T
V
-
D
C
W
R
K
I
A
-------
K
D
E
G
P
K
----
A
F
F
K
--
G
A
----------
W
S
N
V
--
L
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
----
I
--------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.75
23%
-63
- C2 -
4C9Q
5
ADT3_YEAST
A:
[29-318]
---------------------------------------------------------------------------------------------------------------
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
--
I
E
R
V
K
I
L
I
Q
N
---------------------
Q
D
E
M
I
K
Q
G
T
L
D
K
-----------
K
-
Y
S
-
G
I
V
D
C
F
K
R
T
A
K
Q
-
E
G
L
I
-----------
S
F
W
R
G
N
T
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
----
F
K
D
K
I
-----
K
L
M
F
--
G
-----
F
K
----
K
E
-
G
-------
Y
G
K
W
F
A
G
N
L
A
S
G
G
A
A
G
A
----
L
S
L
L
F
V
Y
S
L
D
F
A
-
R
T
R
L
A
A
D
A
K
-
S
-------
A
R
Q
--
F
N-
G
L
T
D
V
Y
K
K
-----
T
L
K
------
S
D
G
I
A
G
L
Y
R
G
F
-----------------------
M
P
-----
S
V
V
G
-
I
V
V
Y
R
G
-
L
Y
--------
F
G
M
---
F
--
D
S
L
K
P
L
-----------------------
F
L
A
S
F
L
L
G
W
V
V
T
------
T
G
-
A
S
T
C
S
Y
-------
P
L
D
T
V
R
R
R
----
M
M
M
T
---
S
G
Q
A
V
------
K
-----
Y
N
G
A
I
-
D
C
L
K
K
I
V
-------
A
S
E
G
V
G
----
S
L
F
K
--
G
C
----------
G
A
N
I
--
L
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
----
Q
L
Q
------
M
I
L
F
G
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.70
23%
-64
- C2 -
4C9J
4
ADT3_YEAST
A:
[29-318]
---------------------------------------------------------------------------------------------------------------
I
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
S
P
--
I
E
R
V
K
I
L
I
Q
N
---------------------
Q
D
E
M
I
K
Q
G
T
L
D
K
-----------
K
-
Y
S
-
G
I
V
D
C
F
K
R
T
A
K
Q
-
E
G
L
I
-----------
S
F
W
R
G
N
T
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
----
F
K
D
K
I
-----
K
L
M
F
--
G
-----
F
K
----
K
E
E
G
-------
Y
G
K
W
F
A
G
N
L
A
S
G
G
A
A
G
A
----
L
S
L
L
F
V
Y
S
L
D
F
A
-
R
T
R
L
A
A
D
A
K
-
S
-------
A
R
Q
--
F
N-
G
L
T
D
V
Y
K
K
-----
T
L
K
------
S
D
G
I
A
G
L
Y
R
G
F
-----------------------
M
P
-----
S
V
V
G
-
I
V
V
Y
R
G
-
L
Y
--------
F
G
M
---
F
--
D
S
L
K
-----------------------------
F
L
L
G
W
V
V
T
------
T
G
-
A
S
T
C
S
Y
-------
P
L
D
T
V
R
R
R
----
M
M
M
T
---
S
G
Q
A
V
------
K
-----
Y
N
G
A
I
-
D
C
L
K
K
I
V
-------
A
S
E
G
V
G
----
S
L
F
K
--
G
C
----------
G
A
N
I
--
L
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
----
Q
L
Q
------
M
I
L
F
G
-------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
76.28
24%
-55
- C2 -
1OKC
10
ADT1_BOVIN
A:
[4-293]
----------------------------------------------------------------------------------------------------------
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
A
P
--
I
E
R
V
K
L
L
L
Q
V
Q
H
---------
A
S
K
-
Q
I
S
-------------
A
E
-----------
K
-
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
-
Q
G
F
L
-----------
S
F
W
R
G
N
L
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
F
K
D
K
Y
K
Q
I
F
-----
L
G
G
V
--
D
RHKQ
F
W
R
----
Y
F
A
G
-------
N
-------
L
A
S
G
G
A
A
G
A
----
T
S
L
C
F
V
Y
P
L
D
F
A
-
R
T
R
L
A
A
D
V
G
-
K
-
G
AA--
Q
R
E
F
--
T
--
G
L
G
N
C
I
T
K
-----
I
F
K
------
S
D
G
L
R
G
L
Y
Q
G
F
-----------------------
N
V
-----
S
V
Q
G
I
I
I
-
Y
R
A
-
A
Y
--------
F
G
V
---
Y
--
D
T
A
K
G
M
L
P
D
P
K
---------------
N
V
H
I
I
V
S
W
M
I
A
Q
T
V
T
------
A
V
-
A
G
L
V
S
Y
-------
P
F
D
T
V
R
R
R
----
M
------
M
M
Q
S
G
RKGADI
M
-----
Y
T
G
T
V
-
D
C
W
R
K
I
A
-------
K
D
E
G
P
K
----
A
F
F
K
--
G
A
----------
W
S
N
V
--
L
R
G
M
G
-
G
A
F
V
L
V
L
Y
D
----
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.17
24%
-66
- C2 -
4C9H
5
ADT2_YEAST
A:
[21-314]
-----------------------------------------------------------------------------------------------------------
S
N
F
L
I
D
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
S
P
--
I
E
R
V
K
L
L
I
Q
N
---------------------
Q
D
E
M
L
K
Q
G
T
L
D
R
-----------
K
-
Y
A
-
G
I
L
D
C
F
K
R
T
A
T
Q
-
E
G
V
I
-----------
S
F
W
R
G
N
T
A
-
N
V
I
R
Y
F
P
T
Q
A
L
N
-
F
A
----
F
K
D
K
I
-----
K
A
M
F
--
G
-----
F
K
----
K
E
E
G
-------
Y
A
K
W
F
A
G
N
L
A
S
G
G
A
A
G
A
----
L
S
L
L
F
V
Y
S
L
D
Y
A
-
R
T
R
L
A
A
D
S
----------
A
R
Q
--
F
N-
G
L
I
D
V
Y
K
K
-----
T
L
K
------
S
D
G
V
A
G
L
Y
R
G
F
-----------------------
L
P
-----
S
V
V
G
-
I
V
V
Y
R
G
-
L
Y
--------
F
G
M
---
Y
--
D
S
L
K
--------------------------
L
A
S
F
L
L
G
W
V
V
T
------
T
G
-
A
S
T
C
S
Y
-------
P
L
D
T
V
R
R
R
----
M
M
M
T
---
S
G
Q
A
V
------
K
-----
Y
D
G
A
F
-
D
C
L
R
K
I
V
-------
A
A
E
G
V
G
----
S
L
F
K
--
G
C
----------
G
A
N
I
--
L
R
G
V
A
G
A
G
V
-
I
S
M
Y
D
----
Q
L
Q
------
M
I
L
F
G
-------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
73.15
24%
-61
- C2 -
2LCK
-
UCP2_MOUSE
A:
[14-299]
--------------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
F
P
--
L
D
T
A
K
V
R
L
Q
I
Q
G
---------
E
S
Q
-
G
L
V
-
R
---------
T
A
A
S
-----------
A
-
Q
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
-
E
G
P
R
-----------
S
L
Y
N
G
L
V
A
-
G
L
Q
R
Q
M
S
F
A
S
V
R
-
I
G
L
Y
D
S
V
K
Q
F
Y
-----
T
K
G
S
--
E
-----
H
A
----
G
I
G
S
-------
R
-------
L
L
A
G
S
T
T
G
A
----
L
A
V
A
V
A
Q
P
T
D
V
V
-
K
V
R
F
Q
A
Q
A
R
-
A
G
G
----
G
R
R
Y
--
Q
--
S
T
V
E
A
Y
K
T
-----
I
A
R
------
E
E
G
I
R
G
L
W
K
G
T
-----------------------
S
P
-----
N
V
A
R
N
A
I
-
V
N
C
-
A
E
--------
L
V
T
---
Y
--
D
L
I
K
D
T
L
L
K
A
N
L
-------------
M
T
D
D
L
P
C
H
F
T
S
A
F
G
A
G
------
F
C
-
T
T
V
I
A
S
-------
P
V
D
V
V
K
T
R
----
Y
------
M
N
S
A
L
G-----
Q
-----
Y
H
S
A
G
-
H
C
A
L
T
M
L
-------
R
K
E
G
P
R
----
A
F
Y
K
--
G
F
----------
M
P
S
F
--
L
R
L
G
S
W
N
V
V
M
F
V
T
Y
E
----
Q
L
K
------
R
A
L
M
A
-------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.07
24%
-50
- C2 -
2LCK
-
UCP2_MOUSE
A:
[15-292]
---------------------------------------------------------------------------------------------------------------
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
F
P
--
L
D
T
A
K
V
R
L
Q
I
Q
G
---------
E
-----
S
-
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
-----------------
G
V
L
G
T
I
L
T
M
V
R
T
-
E
G
P
R
-----------
S
L
Y
N
G
L
V
A
-
G
L
Q
R
Q
M
S
F
A
S
V
R
-
I
G
L
Y
D
S
V
K
Q
F
Y
-----
T
K
G
S
--
E
-----
H
A
----
G
I
G
S
-------
R
-------
L
L
A
G
S
T
T
G
A
----
L
A
V
A
V
A
Q
P
T
D
V
V
-
K
V
R
F
Q
A
Q
A
R
-
A
-
G
----
G
G
R
R
Y-
Q
--
S
T
V
E
A
Y
K
T
-----
I
A
R
------
E
E
G
I
R
G
L
W
K
G
T
-----------------------
S
P
-----
N
V
A
---
R
-
N
A
I
-
V
N
C
A
E
-----
L
V
T
---
Y
--
D
L
I
K
D
T
L
L
K
----
A
N
L
M
T
D
D
L
P
C
---------
H
F
T
S
A
F
G
A
G
------
F
C
-
T
T
V
I
A
S
-------
P
V
D
V
V
K
T
R
----
Y
------
M
N
S
A
L
G-----
Q
-----
Y
H
S
A
G
-
H
C
A
L
T
M
L
-------
R
K
E
G
P
R
----
A
F
Y
K
--
G
F
----------
M
P
S
F
--
L
R
L
G
S
W
N
V
V
M
F
V
T
Y
E
----
Q
L
K
------
R
A
L
M
A
-------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
60.71
20%
-49
- C2 -
1OKC
8
ADT1_BOVIN
A:
[5-201]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
S
F
L
K
-------
D
-------
F
L
A
G
G
V
A
A
A
----
I
S
K
T
A
V
A
P
I
E
R
V
-
K
L
L
L
Q
V
Q
H
A
-
S
-
K
QISA
E
K
Q
Y
--
K
--
G
I
I
D
C
V
V
R
-----
I
P
K
------
E
Q
G
F
L
S
F
W
R
G
N
-----------------------
L
A
-----
N
V
I
R
Y
F
P
-
T
Q
A
-
L
N
--------
F
A
F
---
K
--
D
K
Y
K
Q
I
F
L
G
G
V
D
-
R
H
--------
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
------
A
T
-
S
L
C
F
V
Y
-------
P
L
D
F
A
R
T
R
----
L
------
A
A
D
V
G
KGAAQR
E
-----
F
T
G
L
G
-
N
C
I
T
K
I
F
-------
K
S
D
G
L
R
----
G
L
Y
Q
--
G
F
----------
N
V
S
V
--
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
----
T
A
K
------
G
M
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
58.28
12%
-62
- C1 -
6MHT
2
MTH1_HAEPH
A:
[1-327]
-------------------------------------------------------------------------------------------------MIEIKDK
Q
L
T
G
L
R
F
I
D
L
F
A
G
-
L
G
G
F
R
L
A
L
E
S
C
G
--
A
E
C
V
Y
S
N
E
W
D
K
Y
---------
A
Q
E
-
V
Y
E
-
M
N
F
G
-
E
K
P
E
G
D
I
T
Q
VNEKTIPDHD
I
L
-
C
A
G
F
P
C
Q
A
F
S
I
S
G
K
Q
-
K
G
F
E
DSRGT
L
F
F
D
I
A
R
I
V
R
E
K
K
P
-
K
V
V
F
M
E
N
V
K
N
F
A
-
S
H
D
N
G
N
T
L
E
V
V
-----
K
N
T
M
--
N
-----
E
L
----
D
Y
S
F
-------
H
-------
A
K
V
L
N
A
L
D
Y
----
G
I
P
Q
K
R
E
R
I
Y
M
I
-
C
F
R
N
D
L
N
I
Q
-
N
F
Q
----
F
P
K
P
--
F
--
E
L
N
T
F
V
K
D
-----
L
L
L
------
P
D
S
E
V
E
H
L
V
I
D
-----------------------
R
K
-----
D
L
V
M
-
T
N
-
Q
E
I
-
E
Q
--------
T
T
P
---
K
--
T
V
R
L
G
I
V
G
K
G
G
Q
-
G
E
R
I
Y
S
T
R
G
I
A
I
T
L
S
A
Y
G
G
G
I
F
A
K
T
G
G
Y
------
L
V
-
N
--------------------------------
G
K
--------------
T
R
K
L
H
-
P
R
E
C
A
R
V
-------
M
--
G
Y
P
----
D
S
Y
K
VH
P
S
----------
T
S
Q
A
--
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
----
I
A
Y
------
N
I
G
S
S
L
N
FKPY-------------------------------------------------------------------------------------------------------------------------------
28
Fugue
57.70
18%
-53
- C1 -
4J1Q
1
A:
[20-445]
--------------------------------------------------------------H
M
E
R
L
M
L
E
P
V
WEKQNEELSYT
E
H
I
I
V
L
F
ETE
R
S
V
T
D
S
I
A
S
H
M
K
D
A
R
V
I
T
L
N
E
A
V
G
H
I
A
E
R
Y
Q
C
Y
M
Q
N
I
--
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
R
I
I
I
Q
A
I
V
P
L
-
E
K
E
-
K
Q
L
F
A
G
V
S
G
L
F
K
T
A
-----------
E
-
I
E
F
S
K
L
T
A
Q
V
I
E
I
E
K
P
E
E
M
I
-----------
D
L
H
L
K
L
K
D
-
D
S
R
R
P
F
D
K
Q
I
R
Y
-
E
A
G
Y
R
F
V
K
G
W
R
-----
E
M
V
D
--
T
-----
L
H
M
PWR
D
E
G
V
-------
Y
-------
L
I
T
G
G
A
G
S
L
----
G
L
L
F
A
K
E
I
A
N
R
T
G
R
S
T
I
V
L
T
G
R
-
S
-
V
L---
S
E
D
K
--
E
--
N
E
L
E
A
L
R
S
I
G
A
E
V
V
Y
R
EADVSD
Q
H
A
V
R
H
L
L
E
E
I
-----------------------
K
E
-----
R
Y
G
T
-
L
N
-
G
-
I
-
I
H
G
A
G
S
S
K
D
R
F
I
I
---
H
KT
N
E
E
F
Q
E
V
L
Q
P
K
V
-
S
G
L
L
H
V
D
E
C
S
K
D
F
P
L
D
F
F
I
F
F
S
S
V
S
G
C
L
GNAGQ
A
D
Y
-
A
A
A
N
S
F
-------
M
D
A
F
A
E
Y
R
----
R
------
S
L
A
A
S
------
K
-----
K
R
-
F
G
-
S
T
I
S
F
N
W
PLWEEGG
M
Q
V
G
A
E
----
D
E
K
R
--
M
L
----------
K
T
T
G
--
M
V
P
M
P
T
D
S
G
L
K
A
F
Y
Q
----
G
I
V
S
DKP
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
LL---------------------------------------------------------------------------------------------------------------------------
29
Fugue
56.85
14%
-70
- C1 -
1MLD
1
MDHM_PIG
A:
[1-313]
---------------------------------------------------------------------------------------------------------------
A
K
V
A
V
L
G
A
S
G
G
I
G
Q
P
L
S
L
L
--
L
K
N
-
S
P
--
L
V
S
R
---------
L
T
L
-
Y
D
I
-
A
----
H
T
P
G
V
A
A
D
L
-----------
S
H
I
--
E
T
R
A
T
V
K
G
Y
L
G
P
-
E
Q
L
P
-----------
D
C
L
K
G
C
D
V
-
V
V
I
P
A
G
V
P
R
---------
K
P
G
M
T
R
-----
D
D
L
F
--
N
-----
T
N
----
A
T
I
V
-------
A
-------
T
L
T
A
A
C
A
Q
H
CPD
A
M
I
C
I
I
S
N
P
V
N
S
T
-
I
P
I
T
A
E
V
F
K
-
K
-
H
----
G
V
Y
N
--
P
--
N
K
I
F
G
V
-
T
-----
T
L
D
------
I
V
R
A
N
A
F
V
A
E
L
K
GLDPAR
V
S
V
P
V
I
G
GHAGKTIIP
L
I
-----
S
Q
C
T
------
P
-
K
---------
V
D
F
---
P
------
Q
D
Q
L
S
-
T
L
-
T
G
R
I
Q
E
A
G
T
E
V
V
K
A
K
A
G
A
G
S
A
T
L
S
M
A
Y
A
------
G
A
-
R
F
V
F
S
L
V
D
A
M
N
GK
E
G
V
V
E
C
S
F
----
V
------
K
S
Q
E
T
-------------
D
C
P
Y
-
F
S
T
P
L
L
L
-------
G
K
K
G
I
E
----
K
N
L
G
IG
K
I
----------
S
P
F
E
--
E
K
M
I
A
E
A
I
P
E
L
K
A
S
I
----
K
K
G
------
E
E
F
V
-
K
N
M----------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
53.16
27%
-32
- C2 -
2LCK
-
UCP2_MOUSE
A:
[115-303]
------------------------------------------------------------------------------------------------------------
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
--
T
D
V
V
K
V
R
F
Q
A
Q
A
---------
R
A
G
-
G
----------------
G
-----------
R
-
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
-
E
G
I
R
-----------
G
L
W
K
G
T
S
P
-
N
V
A
R
N
A
I
V
N
C
A
E
-
L
V
T
Y
D
L
I
K
D
T
L
-----
L
K
A
N
L-
M
-----
T
D
----
D
L
P
C
-------
H
-------
F
T
S
A
F
G
A
G
F
----
C
T
T
V
I
A
S
P
V
D
V
V
-
K
T
R
Y
M
N
S
A
L
---------
G
Q
Y
--
H
--
S
A
G
H
C
A
L
T
-----
M
L
R
------
K
E
G
P
R
A
F
Y
K
G
F
-----------------------
M
P
-----
S
F
L
R
L
G
S
-
W
N
V
-
V
M
--------
F
V
T
---
Y
--
E
Q
L
K
R
A
L
M
A
A
Y
Q
-
S
R
E
A
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
50.23
17%
-36
- C1 -
5BP8
1
?
A:
[6-520]
A
P
R
E
A
E
A
A
A
L
L
A
A
T
V
A
D
PWGLVAPSV
Y
D
T
A
R
L
V
S
LAPWLDG
H
R
E
R
L
G
Y
L
A
K
E
QNQDGSWGAPDGYG
L
V
P
T
L
S
A
V
E
A
L
L
T
E
L
A
R
TDSGAPHLS
P
D
D
L
A
A
A
C
A
D
G
L
G
A
L
R
D
G
L
---
L
A
G
P
V
P
D
T
I
G
V
E
F
V
A
P
S
L
L
A
D
I
N
T
R
L
A
A
----------------
L
T
-
E
Q
A
P
G
K
L
G
A
W
S
G
T
T
-----------
L
-
T
S
P
A
P
D
L
-----------
D
G
-----------
A
L
L
A
G
V
R
E
M
T
E
Q
A
P
L
P
E
K
L
W
H
T
L
E
A
V
T
R
D
G
T
R
G
-----
A
R
P
H
--
E
-----
G
A
----
P
P
H
N
-------
G
-------
S
V
G
C
S
P
A
A
T
----
A
A
W
L
G
A
A
P
-----------------------
D
P
A
--
A
--
P
G
V
A
Y
L
R
D
-----
V
Q
A
------
R
F
G
------
G
P
-----------------------
V
P
-----
S
I
T
P
-
I
--
V
Y
F
-
E
Q
--------
A
W
V
---
L
--
N
S
L
A
A
S
G
L
R
Y
E
A
-
P
A
A
L
L
D
S
L
E
A
G
L
T
D
E
G
I
A
A
A
P
G
L
P
S
D
S
D
------
D
T
-
A
A
V
L
F
A
-------
L
A
Q
H
G
R
T
H
RP
D
S
L
M
-----
H
F
R
R
D
------
G
-----
Y
F
S
C
F
-
G
V
E
R
T
P
--------
S
T
S
T
N
A
----
H
I
L
E
--
A
L
----------
G
H
H
V
--
T
V
R
P
D
D
A
G
R
Y
G
A
E
I
R
M
---
I
S
D
------
W
L
L
D
N
QLPDG
S
W
M
D
KWHAS
P
Y
Y
A
T
A
C
C
A
L
A
L
A
E
FGGPSA
R
A
A
V
D
R
A
A
A
W
A
L
A
T
QRADGSWGRWQGT
T
E
E
T
A
Y
M
V
Q
L
L
M
R
T
RTPGSPG
T
V
A
R
S
A
A
R
G
C
D
A
L
L
A
HDDPASYPGL
W
H
D
KDIYAP
V
T
V
I
R
A
A
R
L
A
A
L
A
L
G
GA
16
HHSearch
40.18
11%
-44
- C2 -
3F2E
1
?
A:
[8-90]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
T
--
A
V
A
E
Q
V
S
A
-----
V
L
S
------
Q
Y
G
I
T
G
P
N
R
A
I
-----------------------
Y
Q
-----
G
F
G
L
K
V
A
-
R
A
L
-
N
R
--------
L
G
G
---
G
--
P
A
L
V
N
M
I
N
G
L
K
A
-
Y
Y
I
S
A
F
N
--
A
N
P
T
V
L
D
A
V
T
D
I
I
T
G
S
P
T
G
------
Y
V
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
35.41
18%
-12
- C2 -
3J9X
-
?
A:
[39-81]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
------
Q
T
N
V
P
------
K
-----
F
T
S
V
N
-
E
N
V
S
A
V
L
-------
T
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
--
G
F
----------
G
L
K
V
--
A
R
A
L
N
R
I
G
S
G
P
A
L
V
N
----
M
I
N
------
G
L
K
G
Y
-------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
34.53
7%
-6
- C1 -
2AJA
-
?
A:
[3-349]
--------------------------------------------------------------------------------------------------------
N
L
T
I
H
N
I
E
N
Y
--
E
N
D
P
Q
L
R
L
I
P
W
I
L
W
--
E
N
L
F
Q
H
F
I
S
A
N
E
---------
L
S
L
M
T
L
S
-
Y
K
E
A
I
H
I
F
L
P
G
T
K
N
M
----------
E
-
Q
V
R
Q
L
L
C
L
Y
Y
A
H
Y
N
R
--
N
A
K
-----------
Q
L
W
S
D
A
H
K
-
K
G
I
K
S
E
V
I
C
F
V
A
-
A
I
T
G
C
S
S
A
L
D
T
-----
L
C
L
L
--
S
-----
D
E
----
I
V
K
Q
-------
A
-------
E
N
Y
Q
A
F
R
L
A
----
A
E
-
N
G
H
L
H
V
L
N
R
-
L
C
E
L
A
P
T
E
I
M
A
M
I
----
Q
A
E
N
--
Y
--
H
A
F
R
L
A
A
E
-----
N
G
H
------
L
H
V
L
N
R
L
C
E
L
A
-----------------------
P
T
E
A
T
A
M
I
Q
A
E
-
N
Y
-
Y
A
F
-
R
W
--------
A
A
V
GRG
H
--
H
N
V
I
N
F
L
L
D
C
P
V
M
L
A
Y
A
E
I
H
E
F
E
-
Y
G
E
K
Y
V
N
P
F
I
A
R
H
V
N
R
L
------
K
E
M
H
D
A
F
K
L
-------
S
N
P
D
G
V
F
D
----
L
------
V
T
K
S
E
------
C
-----
L
Q
G
F
Y
M
L
R
N
L
I
R
R
-------
N
D
E
V
L
L
----
D
D
I
R
--
F
L
L
S
IPGIKALA
P
T
A
T
--
I
P
G
D
A
N
E
L
L
R
L
A
L
R
L
GNQ
G
A
C
A
------
L
L
L
S
I
P
S
V
L
A
L
TK-----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
33.07
28%
6
- C2 -
2FGH
1
GELS_HORSE
A:
[299-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
M
E
E
R
K
A
A
L
K
T
A
S
D
F
I
S
K
M
--------------------
D
Y
-------
P
K
Q
T
Q
V
S
V
----
L
------
P
E
G
G
E
------
T
PL---
F
R
Q
F
F
-
K
N
W
R
D
P
D
-------
Q
T
E
G
L
G
----
L
A
Y
----
L
----------
S
S
H
I
AH
V
E
R
V
P
F
D
A
A
T
L
H
T
S
T
----
A
M
A
------
A
Q
H
G
M
-------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
32.10
28%
-2
- C2 -
1D0N
-
GELS_HORSE
A:
[323-402]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
M
E
E
R
K
A
A
L
K
T
A
S
D
F
I
S
K
M
--------------------
D
Y
-------
P
K
Q
T
Q
V
S
V
----
L
------
P
E
G
G
E
------
T
P
L
---
F
R
Q
F
F
-
K
N
W
R
D
P
D
-------
Q
T
E
G
L
G
----
L
A
Y
----
L
----------
S
S
H
I
AH
V
E
R
V
P
F
D
A
A
T
L
H
T
S
T
----
A
M
A
------
A
Q
H
G
M
-------------------------------------------------------------------------------------------------------------------------------------