@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2538_HUMAN: (2015-12-09 )
MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLKS
Atome Classification :
(20 SA)
----------------......--...10..-......20.----.......30.-..--....--.40.....----...50.-.......60..------.....-------.70.-----.......80........90........---100.......110.--------.....------.------120--........-130.......140-.-........150..------.-----..-----.--------...160.....----..170.---...-...180.....-..190.......200...-...-------.210------.......220.....--....230..-----.....240.....------.------.250----.....-------....260------.......270....---...280.......-----290.......300...------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MIQNSR--PSLLQPQ-DV
G
D
T
V
E
T
L
----
M
L
H
P
V
I
K
A
F
L
-CG--SIS
G
--
T
C
S
T
L
L
FQ----
P
L
D
L
L
K
-
T
R
L
Q
TLQPSDH------GS
R
R
V
-------
G
M
L
A
-----
V
L
L
K
V
V
R
T
E
S
L
L
G
L
WKGMSPS
I
V
R
CVP---G
V
G
I
Y
F
G
T
L
Y
S
L
K
Q
--------
Y
F
LRG------H------
P
P
---
T
A
L
E
S
V
M
L
-GVGSR
S
V
A
G
V
C---M-S
P
I
T
V
I
K
T
R--YE------S-----GK-----Y--------
G
Y
E
S
I
Y
A
A
L
R
S
----
I
Y
HSEG---H
R
G
-
L
F
S
G
L
T
A
T
L
L
R-DAPFS
G
I
Y
L
M
F
YNQTKNI-VPH-------DQV
D
------
A
T
L
I
P
ITN--F
S
C
G
I
--
F
A
G
I
L
A
S
L
V-----TQ
P
A
D
V
I
K
T
H
M
Q
L------Y------
P
L
------
K
F
Q
W
I
-------
G
Q
A
V
T
L
I
------
F
K
DYGL
R
G
F
FQGG
I
---
P
R
A
L
R
R
T
L
M
A
A
M
A
-----
W
T
V
Y
E
E
M
M
A
KM-GLKS------------------------------------
6
PsiBlast_PDB
84.74
21%
-77
- C3 -
2C3E
4
ADT1_BOVIN
A:
[8-293]
--------------------------------------------------
L
K
D
F
L
-
A
G
--
G
V
A
A
--
A
I
S
K
T
A
V
A
----
P
I
E
R
V
K
-
L
L
L
Q
V
----
Q
H
------
A
S
K
Q
I
SAEKQYK
G
I
I
D
-----
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
---
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
--------
I
F
L
G
G
VDR---
H
------
K
Q
F
W
-
R
Y
F
A
G
N
L
A
-
S
G
G
A
A
G
A
T
S
L
C
F
--
V
-
Y
P
L
D
F
A
R
T
R
--
L
A
------
A
DV---
G
K
-----
G
--------
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
---
L
R
G
-
L
Y
Q
G
F
N
V
S
V
Q
G
-
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
-
L
P
D
-------
P
K
---------
N
V
H
I
I
V
S
--
W
M
I
A
Q
--
T
V
T
A
V
A
G
L
V
-----
S
Y
P
F
D
T
V
R
R
R
M
M
M
------
Q
SGRKGA
D
I
------
M
Y
T
G
T
-------
V
D
C
W
R
K
I
------
A
K
D
E
G
P
K
A
F
F
K
G
A
W
---
S
N
V
L
-
R
G
M
G
G
A
F
V
-----
L
V
L
Y
D
E
I
---------------------------------------------
5
PsiBlast_PDB
84.12
21%
-77
- C3 -
1OKC
10
ADT1_BOVIN
A:
[8-293]
--------------------------------------------------
L
K
D
F
L
-
A
G
--
G
V
A
A
--
A
I
S
K
T
A
V
A
----
P
I
E
R
V
K
-
L
L
L
Q
V
----
Q
H
------
A
S
K
Q
I
SAEKQYK
G
I
I
D
-----
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
---
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
--------
I
F
L
G
G
VDR---
H
------
K
Q
F
W
-
R
Y
F
A
G
N
L
A
-
S
G
G
A
A
G
A
T
S
L
C
F
--
V
-
Y
P
L
D
F
A
R
T
R
--
L
A
------
A
DV---
G
K
-----
G
--------
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
---
L
R
G
-
L
Y
Q
G
F
N
V
S
V
Q
G
-
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
-
L
P
D
-------
P
K
---------
N
V
H
I
I
V
S
--
W
M
I
A
Q
--
T
V
T
A
V
A
G
L
V
-----
S
Y
P
F
D
T
V
R
R
R
M
M
M
------
Q
SGRKGA
D
I
------
M
Y
T
G
T
-------
V
D
C
W
R
K
I
------
A
K
D
E
G
P
K
A
F
F
K
G
A
W
---
S
N
V
L
-
R
G
M
G
G
A
F
V
-----
L
V
L
Y
D
E
I
---------------------------------------------
25
HHSearch
83.87
20%
-67
* C3 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------
D
----
Q
A
L
S
F
L
K
D
F
L
-
A
G
--
G
V
A
A
--
A
I
S
K
T
A
V
A
----
P
I
E
R
V
K
-
L
L
L
Q
V
Q
H
A
S
K
Q
ISA---
E
K
Q
Y
K
-------
G
I
I
D
-----
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
---
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
--------
I
F
L
G
G
------
V
DRHKQ
F
W
R
---
Y
F
A
G
N
L
A
S
-
G
G
A
A
G
A
T
S
L
C
F
---
V
-
Y
P
L
D
F
A
R
T
R
--
L
A
------
A
-----
D
V
-----
G
KGAAQR--
E
F
T
G
L
G
N
C
I
T
K
----
I
F
K
S
D
G
---
L
R
G
-
L
Y
Q
G
F
N
V
S
V
Q
G
-
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
-
L
P
D
-------
P
K
---------
N
V
H
I
I
V
S
--
W
M
I
A
Q
--
T
V
T
A
V
A
G
L
V
-----
S
Y
P
F
D
T
V
R
R
R
M
M
M
------
Q
------
S
G
RKGADI
M
Y
T
G
T
-------
V
D
C
W
R
K
I
------
A
K
D
E
G
P
K
A
F
F
K
G
A
W
---
S
N
V
L
R
G
M
G
-
G
A
F
V
-----
L
V
L
Y
D
E
I
---------------------------------------------
34
Fugue
82.74
20%
-78
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
----------------------------------------
D
----
Q
A
L
S
F
L
K
D
F
L
-
A
G
--
G
V
A
A
--
A
I
S
K
T
A
V
A
----
P
I
E
R
V
K
-
L
L
L
Q
V
Q
H
A
S
K
Q
------
I
S
A
E
K
QYK----
G
I
I
D
-----
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
---
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
--------
I
F
L
G
G
VDRHKQ
F
------
W
R
---
Y
F
A
G
N
L
A
S
-
G
G
A
A
G
A
T
S
L
C
F
---
V
-
Y
P
L
D
F
A
R
T
R
--
L
A
A
DVGKG
A
-----
A
Q
-----
R
--------
E
F
T
G
L
G
N
C
I
T
K
----
I
F
K
S
D
G
---
L
R
G
-
L
Y
Q
G
F
N
V
S
V
Q
G
-
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
-
L
P
D
-------
P
K
N
V
------
H
---
I
I
V
S
--
W
M
I
A
Q
--
T
V
T
A
V
A
G
L
V
-----
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
SGRKG
A
------
D
I
------
M
Y
T
G
T
-------
V
D
C
W
R
K
I
------
A
K
D
E
G
P
K
A
F
F
K
G
-
A
---
W
S
N
V
L
R
G
M
G
G
A
F
V
-----
L
V
L
Y
D
E
I
---------------------------------------------
38
Fugue
81.22
13%
-98
- C4 -
1FIQ
1
?
B:
[5-309]
------------P
K
Q
L
R
F
E
G
E
R
--
V
T
W
I
Q
A
S
-
T
L
K
E
L
L
D
L
K
----
A
Q
H
P
--
E
A
K
L
-
V
V
--
G
N
T
E
--
I
G
I
E
M
K
F
K
NQLF
P
M
I
I
C
P
-
A
W
I
P
E
L
N
A
V
E
H
------
G
P
E
G
I
-------
S
F
G
A
-----
A
C
A
L
S
S
V
E
K
T
L
L
E
A
V
A
K
L
P
T
Q
K
T
E
V
F
R
---
G
V
L
E
Q
L
R
W
F
A
G
K
Q
V
K
S
V
AS
L
G
G
N
I
I
T
A
------
S
------
P
I
---
S
D
L
N
P
V
F
M
-
A
S
G
T
-------------
K
L
T
I
V
S
R
G
--
T
R
------
R
-----
T
V
-----
P
--------
M
D
H
T
F
F
P
S
Y
R
K
----
T
L
L
G
P
E
---
E
---
I
L
L
S
I
E
I
P
Y
S
R
-
E
D
E
F
F
S
A
F
K
Q
A
S
R
R
E
D
D
I
A
K
V
T
-------
C
G
M
R
------
V
L
F
Q
P
G
S
M
QV
K
E
L
A
L
--
C
Y
G
G
M
A
D
R
T
-----
I
S
A
L
K
T
T
Q
K
-
Q
L
S
------
K
------
F
W
------
N
E
K
L
L
-------
Q
D
V
C
A
G
L
------
A
E
E
L
S
L
S
P
D
A
P
G
G
M
----
I
E
F
R
R
T
L
T
L
S
F
F
-----
F
K
F
Y
L
T
V
L
K
K
L
-
G
---------------------------------------
22
PsiBlast_CBE
78.13
32%
-61
- C3 -
4C9Q
5
ADT3_YEAST
B:
[138-316]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
F
A
R
-
T
R
L
A
A
D
A
-----------
A
R
Q
F
N------
G
L
T
D
-----
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
F
D
S
L
K
P
--------
L
V
---------------------
S
F
L
A
S
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
N
G
A
I
D
C
L
K
K
----
I
V
A
S
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
S
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
M
I
-
L
F
G
-------
K
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.97
32%
-56
- C3 -
4C9J
4
ADT3_YEAST
B:
[138-316]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
F
A
R
-
T
R
L
A
A
D
A
K
S
S
--------
A
R
Q
F
N------
G
L
T
D
-----
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
F
D
S
L
--------------------------------------
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
N
G
A
I
D
C
L
K
K
----
I
V
A
S
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
S
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
M
I
-
L
F
G
-------
K
K
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.33
32%
-58
- C3 -
4C9H
5
ADT2_YEAST
A:
[134-312]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
Y
A
R
-
T
R
L
A
A
D
S
-----------
A
R
Q
F
N------
G
L
I
D
-----
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
Y
D
S
L
K
----------------------------------
L
A
S
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
D
G
A
F
D
C
L
R
K
----
I
V
A
A
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
G
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
M
I
-
L
F
G
-------
K
K
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.85
32%
-60
- C3 -
4C9Q
5
ADT3_YEAST
A:
[138-316]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
F
A
R
-
T
R
L
A
A
D
A
K
S
---------
A
R
Q
F
N------
G
L
T
D
-----
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
F
D
S
L
K
P
--------
L
-----------------------
F
L
A
S
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
N
G
A
I
D
C
L
K
K
----
I
V
A
S
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
S
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
M
I
-
L
F
G
-------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.95
32%
-58
- C3 -
4C9H
4
ADT2_YEAST
B:
[134-309]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
Y
A
R
-
T
R
L
A
A
D
S
K
---------
G
A
R
Q
F
N------
G
L
I
D
-----
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
Y
D
S
L
K
----------------------------------
L
A
S
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
D
G
A
F
D
C
L
R
K
----
I
V
A
A
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
G
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.82
25%
-78
- C3 -
2LCK
-
UCP2_MOUSE
A:
[17-294]
-----------------------------------------------------
F
L
-
G
A
--
G
T
A
A
--
C
I
A
D
L
I
T
F
----
P
L
D
T
A
K
-
V
R
L
Q
-
I
Q
G
E
S
Q
------
G
L
V
R
T
A
ASAQYR
G
V
L
G
-----
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
---
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
--------
F
Y
T
K
G
------
S
------
E
H
---
A
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
---
A
-
Q
P
T
D
V
V
K
V
R
--
F
Q
------
A
QARAG
G
G
-----
R
--------
R
Y
Q
S
T
V
E
A
Y
K
T
----
I
A
R
E
E
G
---
I
R
G
-
L
W
K
G
T
S
P
N
V
A
R
-
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
-
L
L
K
-------
A
N
L
M
------
T
D
D
L
P
C
-
H
--
F
T
S
A
F
--
G
A
G
F
C
T
T
V
I
-----
A
S
P
V
D
V
V
K
T
R
Y
M
N
------
S
------
A
L
G-----
Q
Y
H
S
A
-------
G
H
C
A
L
T
M
------
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
---
P
S
F
L
R
L
G
S
W
N
V
V
M
-----
F
V
T
Y
E
Q
L
K
R
A
L
-
M
A
A
Y
------------------------------------
3
PsiBlast_PDB
72.39
32%
-57
- C3 -
4C9J
4
ADT3_YEAST
A:
[138-316]
---------------------------------------------------------
G
--
G
A
A
G
--
A
L
S
L
L
F
V
Y
----
S
L
D
F
A
R
-
T
R
L
A
A
D
A
K
S
---------
A
R
Q
F
N------
G
L
T
D
-----
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
---
Y
R
G
L
Y
F
G
M
F
D
S
L
K
-------------------------------------
F
L
L
-
G
W
V
V
T
T
G
A
S
T
C
---
S
-
Y
P
L
D
T
V
R
R
R
M
M
M
T
------
S
-----
G
Q
A----
V
--------
K
Y
N
G
A
I
D
C
L
K
K
----
I
V
A
S
E
G
---
V
G
S
-
L
F
K
G
C
G
A
N
I
L
R
-
S
V
A
G
A
G
V
I
S
M
-
Y
D
Q
L
Q
M
I
-
L
F
G
-------
K
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
72.33
11%
-96
* C4 *
1FO4
1
?
A:
[230-531]
------------------
E
G
E
R
--
V
T
W
I
Q
A
S
-
T
L
K
E
L
L
D
L
K
----
A
Q
H
P
E
-
A
K
L
V
-
V
G
N
T
E
I
G
I
--
E
M
K
F
K
N
Q
L
----
F
P
M
I
I
C
P
A
W
I
P
E
L
N
A
V
E
H
------
G
P
E
G
I
-------
S
F
G
A
-----
A
C
A
L
S
S
V
E
K
T
L
L
E
A
V
A
K
L
P
T
Q
K
T
E
V
F
R
---
G
V
L
E
Q
L
R
W
F
A
G
K
Q
V
--------
K
S
----------------
V
A
---
S
L
G
G
N
I
I
T
-
A
S
P
I
S
D
L
N
P
V
F
---
M
-
A
S
G
T
K
L
T
I
V
--
S
R
------
G
-----
T
R
-----
R
--------
T
V
P
M
D
H
T
F
F
P
S
----
Y
R
K
T
L
L
---
G
P
E
E
I
L
L
S
I
E
I
P
Y
S
R
-
E
D
E
F
F
S
A
F
K
Q
A
S
R
R
E
D
D
I
-
A
K
----------
V
T
------
C
G
M
R
V
L
F
Q
--
P
G
S
M
Q
--
V
K
E
L
A
L
C
Y
G
GMADR
T
I
S
A
L
K
T
T
Q
K
Q
L
S
------
K
------
F
W
------
N
E
K
L
L
-------
Q
D
V
C
A
G
L
------
A
E
E
L
S
L
S
P
D
A
P
G
G
----
M
I
E
F
R
R
T
L
T
L
S
F
F
-----
F
K
F
Y
L
T
V
L
K
K
L
-
G
K
D
S
------------------------------------
39
Fugue
70.64
19%
-73
- C1 -
4D6W
1
GLYCO_CHAV
A:
[1-415]
Y
L
S
I
A
F
PENTKLD
W
K
P
V
T
K
N
T
R
Y
C
P
P
G
L
Q
E
E
-
S
F
L
S
S
T
P
I
G
----
A
T
P
S
K
S
D
G
F
L
-
C
H
--
A
A
K
W
V
T
T
C
D
F
R
W
Y
G
----
P
-
K
Y
I
T
-
H
S
I
H
N
I
K
P
T
R
S
------
D
C
D
T
A
-------
L
A
S
Y
K
S
GTL
V
S
L
G
F
P
P
E
S
C
G
Y
A
S
V
T
D
S
E
F
L
V
I
M
I
T
P
H
H
V
G
V
D
D
Y
R
G
--
H
W
V
D
P
--------
L
F
V
G
G
------
E
CD----
Q
S
Y
C
D
T
I
H
N
S
S
V
W
-
I
P
A
D
Q
T
K
K
N
I
C
G
Q
S
F
-
T
P
L
T
V
T
V
A
Y
--
D
K
------
T
-----
K
E
-----
I
--------
A
A
G
G
I
V
F
K
S
K
Y
----
H
S
H
M
E
G
AR
T
C
R
L
-
S
Y
C
G
R
N
G
I
K
F
P
-
N
G
E
W
V
S
L
D
V
K
T
R
I
Q
E
K
H
L
-
L
P
L
FKECPAG
T
E
V
R
------
S
T
L
Q
S
D
G
A
Q
V
L
T
S
E
I
--
Q
R
I
L
D
Y
S
L
C
-----
Q
N
T
W
D
K
V
E
R
K
E
P
L
------
S
------
P
L
------
D
L
S
Y
L
ASKSP
G
K
G
L
A
Y
T
V
I
NGTL
S
F
A
H
T
R
Y
V
R
M
W
I
D
G
P
V
LKE
P
K
G
K
R
E
S
P
S
G
I
S
S
DIWT
Q
W
F
K
Y
G
D
M
E
I
G
P
N
G
L
L
K
TAG
G
Y
K
F
P
W
H
L
I
G
M
G
I
V
D
N
E
L
H
E
L
S
E
A
N
P
L
D
H
P
Q
L
P
24
HHSearch
70.31
24%
-72
- C3 -
2LCK
-
UCP2_MOUSE
A:
[14-300]
--------------------------------------------------
T
V
K
F
L
-
G
A
--
G
T
A
A
--
C
I
A
D
L
I
T
F
----
P
L
D
T
A
K
-
V
R
L
Q
I
Q
G
E
S
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
-------
G
V
L
G
-----
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
---
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
--------
F
Y
T
K
G
S-----
E
------
H
A
---
G
I
G
S
R
L
L
A
-
G
S
T
T
G
A
L
A
V
A
V
---
A
-
Q
P
T
D
V
V
K
V
R
--
F
Q
------
A
-----
Q
A
RAGGG
R
--------
R
Y
Q
S
T
V
E
A
Y
K
T
----
I
A
R
E
E
G
---
I
R
G
-
L
W
K
G
T
S
P
N
V
A
R
-
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
-
L
L
K
-------
A
N
L
M
-------
T
D
D
L
P
C
H
--
F
T
S
A
F
--
G
A
G
F
C
T
T
V
I
-----
A
S
P
V
D
V
V
K
T
R
Y
M
N
------
S
------
A
L
G-----
Q
Y
H
S
A
-------
G
H
C
A
L
T
M
------
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
---
P
S
F
L
R
L
G
S
W
N
V
V
M
-----
F
V
T
Y
E
Q
L
K
R
A
L
-
M
A
A
Y
------------------------------------
40
Fugue
66.04
16%
-99
- C4 -
4KXR
-
?
C:
[8-298]
-------------T
D
I
T
V
N
V
D
G
--
F
W
M
L
Q
A
L
L
D
I
R
H
V
A
P
E
L
R
C
R
P
Y
V
H
P
G
M
A
V
M
R
E
Q
G
--
I
V
V
N
--
D
A
V
N
----------
E
Q
V
A
-
A
R
M
K
V
L
A
A
P
D
---------------------
L
E
-----
V
V
A
L
L
S
R
G
K
L
L
Y
G
V
I
D
D
E
N
Q
P
-----
P
---
G
-----------------------
S
R
D
------
I
------
P
D
---
N
E
F
R
V
V
L
A
-
R
R
G
Q
H
W
V
S
A
V
R
---
V
G
N
D
I
T
V
D
D
V
T
--
V
S
------
D
-----
S
A
-----
S
--------
I
A
A
L
V
M
D
G
L
E
S
----
I
H
H
A
D
P
---------
A
A
I
N
A
V
N
V
P
-
M
E
E
M
L
E
A
T
K
S
W
Q
E
S
G
F
N
V
-
F
S
G
-------
G
D
L
R
R
M
GIS
A
A
T
V
A
A
L
G
Q
--
A
L
S
D
P
--
A
A
E
V
A
V
Y
A
R
-----
Q
Y
R
D
D
A
K
G
P
S
A
S
V
------
L
------
S
L
------
K
D
G
S
G
-------
G
R
I
A
L
Y
Q
------
Q
A
R
E
A
W
L
A
I
C
P
A
T
----
P
Q
L
V
Q
V
G
V
K
T
V
L
D
-----
T
L
P
Y
G
E
W
K
T
H
S
-----------------------------------------
42
Fugue
65.42
8%
-92
- C2 -
1C3Q
2
THIM_BACSU
A:
[13-284]
---------------------------
M
D
A
Q
-
S
A
A
K
C
L
T
A
V
----
R
R
H
S
P
L
V
H
S
I
-
T
N
--
N
V
V
T
--
N
F
T
A
N
G
L
L
----
A
L
G
A
S
P
-
V
M
A
Y
A
K
E
E
V
A
D
------
M
A
K
I
A
-------
G
A
L
V
-----
L
N
I
G
T
L
S
K
E
S
V
E
A
M
I
I
A
G
K
S
A
N
E
H
G
V
P
---
V
I
L
D
P
V
G
A
G
A
T
P
F
R
--------
T
E
S
A
R
------
D
------
I
I
---
R
E
V
R
L
A
A
I
-
R
G
N
A
A
E
I
A
H
T
V
------
G
V
T
D
W
L
I
K
--
G
V
------
D
-----
A
G
-----
E
--------
G
G
G
D
I
I
R
L
A
Q
Q
----
A
A
Q
K
L
N
---
T
V
I
-
A
I
T
G
E
V
D
V
I
A
D
-
T
S
H
V
Y
T
L
-----------------------
H
N
G
------
H
K
L
L
T
K
V
T
--
G
A
G
C
L
--
L
T
S
V
V
G
A
F
C
-----
A
V
E
E
N
----
P
L
F
A
------
A
------
I
A
------
A
I
S
S
Y
-------
G
V
A
A
Q
L
A
------
A
Q
Q
T
A
D
K
G
---------
P
G
S
F
Q
I
E
L
L
N
K
L
S
-----
T
V
T
E
Q
D
V
Q
E
W
A
-
T
I
E
R
V
TVS--------------------------------
27
HHSearch
63.50
21%
-68
- C3 -
1OKC
8
ADT1_BOVIN
A:
[4-203]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
---
S
F
L
K
D
F
L
A
-
G
G
V
A
A
A
I
S
K
T
A
---
V
-
A
P
I
E
R
V
K
L
L
--
L
Q
------
V
-----
Q
H
-----
A
SKQISAEK
Q
Y
K
G
I
I
D
C
V
V
R
----
I
P
K
E
Q
G
---
F
L
S
-
F
W
R
G
N
L
A
N
V
I
R
-
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
-
F
L
G
-------
G
V
D
R
HKQ---
F
W
R
Y
F
A
G
N
--
L
A
S
G
G
--
A
A
G
A
T
S
L
C
F
-----
V
Y
P
L
D
F
A
R
T
R
L
A
A
------
D
------
V
G
KGAAQR
E
F
T
G
L
-------
G
N
C
I
T
K
I
------
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
---
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
-----
F
G
V
Y
D
T
A
K
G
M
L
-
P
D
P
K
------------------------------------
26
HHSearch
62.15
24%
-60
- C3 -
2LCK
-
UCP2_MOUSE
A:
[113-302]
----------------------------------------------
H
A
G
I
G
S
R
L
L
-
A
G
--
S
T
T
G
--
A
L
A
V
A
V
A
Q
----
P
T
D
V
V
K
-
V
R
F
Q
A
Q
A
R
A
G
G
------
G
R
R
Y
Q
-------
S
T
V
E
-----
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
---
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
--------
T
L
L
K
A
------
N
LM----
T
D
---
D
L
P
C
H
F
T
S
-
A
F
G
A
G
F
C
T
T
V
I
---
A
-
S
P
V
D
V
V
K
T
R
--
Y
M
------
N
-----
S
A
L----
G
--------
Q
Y
H
S
A
G
H
C
A
L
T
----
M
L
R
K
E
G
---
P
R
A
-
F
Y
K
G
F
M
P
S
F
L
R
-
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
-
L
M
A
-------
A
Y
Q
S
------
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
45.10
25%
-47
- C3 -
1BPE
-
DPOLB_RAT
A:
[224-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
D
T
L
S
K
G
E
T
K
F
M
G
V
C
Q
L
P
S
E
---
N
E
-
Y
P
H
-------
R
R
I
D
------
I
R
L
I
P
K
D
Q
--
Y
Y
C
G
V
L
Y
F
T
G
--------------
S
D
I
F
N
K
N
M
R
A
------
H
------
A
L
------
E
K
G
F
T
-------
I
N
E
Y
T
I
R
------
P
L
G
V
T
G
V
A
G
E
P
L
P
V
---
D
S
E
Q
D
I
F
D
Y
I
Q
W
R
-----
Y
R
E
P
K
D
R
S
E
-------------------------------------------