@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2539_HUMAN: (2015-12-09 )
MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRLLGG
Atome Classification :
(20 SA)
-------------------------------.........10.....--...-20........30...-......40..----..--..-..50...-------------.....60........70...----.....80....-....90........100-----..--------------......-.110----------------------------.......120....---...130.....----..140.......150-----.....-----..160...-...---.170...---....180---.------------........190------..--------.--------....200-------........210.......--220.......230-..----.....240....-...250--.--.-..------...-------------.260.-----------......270-..-.....280--------------------.-.......290...--..-----..300....-----..----------.310.......320.......330.......340------.......350.......----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------MADQDPA
G
I
S
P
L
Q
Q
M
V
--ASG-
T
G
A
V
V
T
S
L
F
MT-
P
L
D
-
V
V
K
V
R
L
QSQR----P
S
--
M
A
-
S
ELMPSS-------------R
L
W
S
L
S
Y
TKL
P
S
S
L
Q
STG
K
C
----
L
L
Y
CNGVLE
P
L
-
Y
LCPNG
A
R
C
A
T
WFQD-------PT--------------RFTG
T
M
-
D
A
F
V
----------------------------
K
I
V
RHEG
T
R
T
L
WSG---L
P
A
T
L
V
M
T
VPA----
T
A
I
Y
F
T
A
Y
D
Q
L
K
A
F
L
-----C
G
R
A
L
-----
T
S
D
L
Y
A
P
M
-
V
A
G
---
A
L
A
RLG
T
---
V
T
V
I
S
-----
P
------------
L
E
L
M
R
T
K
L
Q
A
Q
------
H
V
--------
S
--------
Y
R
E
L
G
A
--------
C
V
R
T
A
V
AQGGW
R
S
L
W
LGW--GP
T
A
L
RDVP
F
S
A
L
-
Y
W
----
F
N
Y
E
L
V
K
S
W
L
N
G-FRPKD---
Q
--
T
-
S
V
------
G
M
S
-------------
F
V
AGG-----------ISG
T
V
A
A
V
L
-TL-
P
F
D
V
V
K
T
---------------------
Q
-
R
Q
V
A
LG
A
M
E
A
V
R
V--N
P
-----
L
HV
D
S
T
W
L
L
-----
L
R
----------
R
I
R
AESGTK
G
L
F
A
G
F
L
P
R
I
I
K
AAPS
C
A
I
M
I
S
T
Y
E
------
F
G
K
S
F
F
Q
R
L
N
Q
D
RLLGG----------------
34
Fugue
79.54
22%
-64
- C3 -
4P5W
-
CMC2_HUMAN
A:
[31-394]
-------------------------------
T
K
R
A
D
P
A
E
L
R
T
I
F
L
K
Y
--
A
S
I
-
E
K
N
--
G
E
F
F
M
S
-
P
N
D
-
F
V
T
R
Y
L
N
I
F
S
----
Q
P
--
N
P
-
K
T
V
E
L
L
S
-------------
G
V
V
D
Q
T
K
D
G
L
I
S
-------------
F
Q
E
F
V
A
F
E
S
V
--
L
C
A
P
D
A
L
F
M
V
A
F
Q
L
F
DKAGKG
E
V
--------------
T
F
E
D
V
K
-
Q
V
F
G
----------------------------
Q
T
T
I
H
Q
H
I
P
F
N
W
D
S
---
E
F
V
Q
L
H
F
G
K
E
R
----
K
R
-
H
L
T
-
Y
A
E
F
T
Q
F
L
-----
L
E
I
Q
L
-----
E
H
A
K
Q
A
-
F
-
V
Q
R
---
D
N
A
R
T
G
R
---
V
T
A
I
D
-----
F
------------
R
D
I
M
V
T
I
R
--
P
------
H
V
--------
L
--------
T
P
F
V
E
E
--------
C
L
V
A
A
A
G
--------------
G
T
T
S
H
Q
V
S
F
S
Y
F
-
N
G
----
F
N
S
L
L
N
N
---------------------------------------------
M
E
L
-----------
I
R
K
I
Y
S
T
L
A
-
G
T
-
R
K
D
V
E
V
T
---------------------
K
-
E
E
F
V
L
A
A
Q
K
F
G
Q
V
--
T
P
-----
M
E
V
D
I
L
F
Q
L
-----
A
D
----------
L
Y
E
P
R
G
R
M
T
------
L
A
D
I
E
R
I
A
P
P
N
P
D
H
V
G
G
Y
K
------
L
A
V
A
T
F
A
G
I
E
N
K
F
G
L
Y
L
----------------
31
Fugue
77.14
22%
-69
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
--
A
G
G
-
V
A
A
A
I
S
K
T
A
V
A
-
P
I
E
-
R
V
K
L
L
L
Q
V
Q
H
----
A
S
--
K
Q
-
I
--------------------------------------------------------------------
S
A
-------
E
K
--------------
Q
Y
K
G
I
I
-
D
C
V
V
----------------------------
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
---
N
L
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
GGVD
R
H
K
Q
F
-----
W
R
Y
F
A
G
N
L
-
A
S
G
---
G
A
A
G
A
T
S
---
L
C
F
V
Y
-----
P
------------
L
D
F
A
R
T
R
L
A
A
D
VGKGAA
Q
R
--------
E
--------
F
T
G
L
G
N
--------
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
--
N
V
S
V
Q
G
I
I
I
Y
R
A
A
-
Y
F
----
G
V
Y
D
T
A
K
G
M
L
P
----
D
P
K
---
N
--
V
-
H
I
------
I
V
S
-------------
W
M
I
A
Q
-----------
T
V
T
A
V
A
G
L
V
-
S
Y
-
P
F
D
T
V
R
R
---------------------
R
-
M
M
M
Q
S
G
R
K
G
A
D
I
-----------
M
Y
T
G
T
V
D
C
-----
W
R
----------
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
------
I
--------------------------------
22
HHSearch
76.99
23%
-71
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
--
A
G
G
-
V
A
A
A
I
S
K
T
A
V
A
-
P
I
E
-
R
V
K
L
L
L
Q
V
Q
H
----
A
S
--
K
Q
-
I
S
--------------------------------------------------------------------
A
-------
E
K
--------------
Q
Y
K
G
I
I
-
D
C
V
V
----------------------------
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
---
N
L
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
-----
L
G
G
V
D
RHKQ
F
W
R
Y
F
A
G
N
L
-
A
S
G
---
G
A
A
G
A
T
S
---
L
C
F
V
Y
-----
P
------------
L
D
F
A
R
T
R
L
A
A
D
------
V
G
KGAAQR--
E
--------
F
T
G
L
G
N
--------
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
--
N
V
S
V
Q
G
I
I
I
Y
R
A
A
-
Y
F
----
G
V
Y
D
T
A
K
G
M
L
P
D
-
P
K
------
N
--
V
-
H
I
------
I
V
S
-------------
W
M
I
A
Q
-----------
T
V
T
A
V
A
G
L
V
-
S
Y
-
P
F
D
T
V
R
R
---------------------
R
-
M
M
M
Q
S
G
R
K
G
------
A
D
-----
I
M
Y
T
G
T
V
D
C
-----
W
R
----------
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
A
F
V
L
V
L
Y
D
------
E
I
-------------------------------
37
Fugue
75.08
17%
-70
- C6 -
2CY7
-
ATG4B_HUMAN
A:
[5-377]
-------------------------------
T
L
T
Y
D
T
L
R
F
A
E
F
E
D
F
P
--
E
T
S
-
E
P
V
W
I
L
G
----------
R
K
Y
S
I
F
T
E
K
----
D
E
--
I
L
-
S
D
V
--
A
S
-------------
R
L
W
-
F
T
Y
R
K
N
F
P
A
I
G
G
T
G
P
------------------------
T
S
D
T
G
W
G
C
-------
M
L
--------------
R
C
G
Q
M
I
-
F
A
Q
A
----------------------------
L
V
C
R
H
L
G
R
D
W
R
W
T
Q
RKR
Q
P
D
S
Y
F
S
V
L
N
A
F
IDR
K
D
S
Y
Y
S
I
H
Q
I
A
Q
M
G
V
-----
G
E
G
K
S
-----
I
G
Q
W
Y
G
P
N
T
V
A
Q
---
V
L
K
K
L
A
V
---
F
D
T
W
S
-----
S
------------
L
A
V
H
I
A
M
--
D
N
------
T
V
--------
V
--------
M
E
E
I
R
R
--------
L
C
R
T
S
V
P
C
S
P
W
R
P
L
V
L
L
I
---
P
L
R
L
G
L
T
D
I
N
E
A
-
Y
V
----
E
T
L
K
H
C
---------
F
M
M
---
P
--
Q
-
S
L
------
G
----------------
V
I
G
G
-----------
K
P
N
S
A
H
Y
F
I
G
Y
V
-
G
E
E
L
I
Y
L
---------------------
D
-
P
H
T
T
Q
P
A
V
E
G
C
F
I
PD
E
S
-----
F
H
C
Q
H
P
--------
P
C
----------
R
M
S
I
A
E
L
D
P
S
I
A
V
G
F
F
C
K
T
E
D
D
F
N
D
W
C
Q
Q
V
K
K
L
S
------
L
L
P
M
F
E
L
V
E
Q
Q
P
D
V
L
N
L
SLD
S
S
D
V
E
R
L------
2
PsiBlast_PDB
73.53
26%
-88
- C7 -
4C9H
5
ADT2_YEAST
A:
[66-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
A
G
I
L
-
D
C
F
K
----------------------------
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
---
N
T
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
-----
G
F
K
-------
K
E
E
G
Y
A
K
W
-
F
A
G
---
N
L
A
S
G
G
A
---
A
G
A
L
S
L
L
FV
Y
S
------------
L
D
Y
A
R
T
R
L
A
A
D
------
S
-----------------------
A
RQFNG
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
--
L
P
S
V
V
G
I
V
V
Y
R
G
L
-
Y
F
----
G
M
Y
D
S
L
K
---------------------------
L
A
S
-------------
F
L
L
G
W
-----------
V
V
T
T
G
A
S
T
C
-
S
Y
-
P
L
D
T
V
R
------------------------
R
R
M
M
M
T
S
G
Q
A
V
K
------------
Y
D
G
A
F
D
C
-----
L
R
----------
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
---------------------------
1
PsiBlast_PDB
73.06
26%
-83
- C7 -
4C9G
5
ADT2_YEAST
A:
[66-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
A
G
I
L
-
D
C
F
K
----------------------------
R
T
A
T
Q
E
G
V
I
S
F
W
R
G
---
N
T
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
-----
G
F
K
-------
K
E
E
G
Y
A
K
W
-
F
A
G
---
N
L
A
S
G
G
A
---
A
G
A
L
S
L
L
F
V
Y
S
------------
L
D
Y
A
R
T
R
L
A
A
D
------
S
------------------------RQFNG
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
--
L
P
S
V
V
G
I
V
V
Y
R
G
L
-
Y
F
----
G
M
Y
D
S
L
----------------------------
L
A
S
-------------
F
L
L
G
W
-----------
V
V
T
T
G
A
S
T
C
-
S
Y
-
P
L
D
T
V
R
------------------------
R
R
M
M
M
T
S
G
Q
A
V
K
------------
Y
D
G
A
F
D
C
-----
L
R
----------
K
I
V
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q------------------------------------
5
PsiBlast_PDB
70.88
24%
-75
- C7 -
4C9Q
5
ADT3_YEAST
A:
[70-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
S
G
I
V
-
D
C
F
K
----------------------------
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
---
N
T
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
-----
G
F
K
-------
K
E
-
G
Y
G
K
W
-
F
A
G
---
N
L
A
S
G
G
A
---
A
G
A
L
S
L
L
FV
Y
S
------------
L
D
F
A
R
T
R
L
A
A
D
------
A
K
--------
S
-------------
A
RQFNG
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
--
M
P
S
V
V
G
I
V
V
Y
R
G
L
-
Y
F
----
G
M
F
D
S
L
K
P
L
------------------
F
------
L
A
S
-------------
F
L
L
G
W
-----------
V
V
T
T
G
A
S
T
C
-
S
Y
-
P
L
D
T
V
R
------------------------
R
R
M
M
M
T
S
G
Q
A
V
K
Y
--
N
G
------
A
I
D
C
---------
L
K
----------
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
------------------------------
39
Fugue
70.53
19%
-67
- C5 -
3R6O
-
?
A:
[22-323]
-----------------------------------------
M
N
L
R
I
V
S
F
A
W
Q
-
P
G
V
L
I
D
D
D
T
V
A
-
P
L
A
-
P
M
S
A
R
E
L
I
A
L
----
L
P
--
Q
I
-
S
P
L
I
S
D
E
-------------
L
V
-
P
L
D
S
V
A
L
G
A
P
I
P
E
P
G
Q
V
----
I
A
L
G
F
N
---------
Y
P
T
H
D
P
V
V
F
M
K
S
-------
P
T
--------------
S
I
S
G
P
R
-
D
A
-------------------------------
V
I
A
P
R
T
S
H
A
L
D
Y
E
---
I
E
I
A
V
V
I
G
K
P
G
----
Y
R
I
---
E
R
S
Q
A
I
K
H
V
-----
A
G
Y
M
L
-----
A
N
D
I
T
A
----------------------------------------------
R
D
V
A
L
P
F
------
G
Q
--------
A
--------
Q
V
V
R
G
K
--------
G
Y
P
T
F
C
P
T
G
P
W
--
L
F
T
T
G
--
S
D
T
T
F
E
T
F
D
F
E
L
R
-
I
---------------
N
G
-
E
L
R
Q
S
---
G
--
S
-
T
V
------
D
M
T
-------------
L
G
F
A
E
-----------
V
V
E
T
V
S
A
T
I
-
A
L
R
A
G
D
I
I
L
T
-----------------------------------------------------------------------------
G
T
P
G
G
C
G
F
Q
F
D
P
P
R
Y
L
R
P
G
D
V
I
E
A
H
S
A
K
------
L
G
K
M
R
L
P
V
H
D
E
K
P
--------------------
4
PsiBlast_PDB
63.95
24%
-74
- C7 -
4C9J
4
ADT3_YEAST
A:
[70-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
S
G
I
V
-
D
C
F
K
----------------------------
R
T
A
K
Q
E
G
L
I
S
F
W
R
G
---
N
T
A
N
V
I
R
Y
F
P
T
----
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
-----
G
F
K
-------
K
E
E
G
Y
G
K
W
-
F
A
G
---
N
L
A
S
G
G
A
---
A
G
A
L
S
L
L
FV
Y
S
------------
L
D
F
A
R
T
R
L
A
A
D
------
A
K
--------
S
-------------
A
RQFNG
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
--
M
P
S
V
V
G
I
V
V
Y
R
G
L
-
Y
F
----
G
M
F
D
S
L
K
-------------------------------------------
F
L
L
G
W
-----------
V
V
T
T
G
A
S
T
C
-
S
Y
-
P
L
D
T
V
R
------------------------
R
R
M
M
M
T
S
G
Q
A
V
K
Y
--
N
G
------
A
I
D
C
---------
L
K
----------
K
I
V
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
V
A
G
A
G
V
-
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
----------------------------
21
HHSearch
61.33
24%
-59
- C7 -
2LCK
-
UCP2_MOUSE
A:
[14-304]
------------------------------------------
T
V
K
F
L
--
G
A
G
-
T
A
A
C
I
A
D
L
I
T
F
-
P
L
D
-
T
A
K
V
R
L
Q
I
Q
G
----
E
S
--
Q
G
-
L
V
R
-----------------------------------------------------------------
T
A
A
-------
S
A
--------------
Q
Y
R
G
V
L
-
G
T
I
L
----------------------------
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
---
L
V
A
G
L
Q
R
Q
M
S
F
----
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
-----
T
K
G
S
E
-----
H
A
G
I
G
S
R
L
-
L
A
G
---
S
T
T
G
A
L
A
---
V
A
V
A
Q
-----
P
------------
T
D
V
V
K
V
R
F
Q
A
Q
------
A
R
AGGGR---
R
--------
Y
Q
S
T
V
E
--------
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
--
S
P
N
V
A
R
N
A
I
V
N
C
A
-
E
L
----
V
T
Y
D
L
I
K
D
T
L
L
K
-
A
N
L
M
----
T
--
D
-
D
L
------
P
C
H
-------------
F
T
S
A
F
-----------
G
A
G
F
C
T
T
V
I
-
A
S
-
P
V
D
V
V
K
T
---------------------
R
-
Y
M
N
S
A
L
G
----------------
Q
Y
H
S
A
G
H
C
-----
A
L
----------
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
V
T
Y
E
------
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
A
P
F
----------------
3
PsiBlast_PDB
58.29
22%
-63
- C7 -
2LCK
-
UCP2_MOUSE
A:
[16-292]
--------------------------------------------
K
F
L
--
G
A
G
-
T
A
A
C
I
A
D
L
I
T
F
-
P
L
D
-
T
A
K
V
R
L
Q
I
Q
G
----
E
S
--
Q
G
---------------------------
L
V
R
T
A
A
S
A
Q
------------------------------------------------------------
Y
R
G
V
L
-
G
T
I
L
----------------------------
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
---
L
V
A
G
L
Q
R
Q
M
S
F
----
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
-----
T
K
G
S
E
-----
H
A
G
I
G
S
R
L
-
L
A
G
---
S
T
T
G
A
L
A
---
V
A
V
A
Q
-----
P
------------
T
D
V
V
K
V
R
F
Q
A
Q
------
A
R
--------
A
GGGRR---
Y
Q
S
T
V
E
--------
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
--
S
P
N
V
A
R
N
A
I
V
N
C
A
-
E
L
----
V
T
Y
D
L
I
K
D
T
L
---
L
K
A
N
L
---
M
--
T
D
D
L
------
P
C
H
-------------
F
T
S
A
F
-----------
G
A
G
F
C
T
T
V
I
-
A
S
-
P
V
D
V
V
K
T
---------------------
R
Y
M
N
S
A
L
G
Q
Y
H
S
----------------
A
G
H
C
A
-----
L
T
----------
M
L
R
K
E
-
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
V
T
Y
E
------
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
A
P
F
----------------
36
Fugue
58.03
14%
-79
- C4 -
4WID
1
?
A:
[10-362]
KDMAL
Q
H
A
V
D
L
L
E
K
M
L
A
D
E
E
KLTEFNLGDPL
F
E
S
A
N
D
D
P
I
K
T
L
E
E
I
I
--
Q
E
G
-
D
D
V
V
G
A
H
Q
L
V
---
V
T
-
Q
I
K
L
R
V
Q
R
N
R
R
L
A
D
E
I
--
I
R
-
E
Q
L
T
D
I
R
-------------
K
V
F
S
D
K
F
E
K
L
E
Q
G
I
Q
N
S
Y
L
L
----
L
D
K
L
K
T
P
F
Q
D
M
R
C
L
F
E
V
A
N
E
Q
F
N
D
T
P
V
-------
P
P
--------------
Q
Y
K
E
F
M
-
V
C
L
K
----------------------------
Q
I
V
Q
Y
A
V
N
S
S
S
L
-------
E
K
F
V
M
L
I
-----------
T
K
K
D
D
I
K
D
R
V
-----
T
Y
T
C
M
-----
K
Y
L
L
M
A
M
Q
-
G
T
G
GPK
A
I
N
N
E
E
H
---
A
K
L
F
F
-----
Q
------------
L
S
N
Y
D
D
L
T
D
A
N
------
H
D
--------
G
--------
L
E
L
I
K
K
--------
L
D
K
E
Q
--------------------
K
E
V
A
F
H
V
N
-
N
F
----
T
H
--
L
V
T
T
L
G
M
A
-
L
Y
K
E
G
---
H
--
Q
-
K
N
------
D
E
A
-------------
M
L
G
---------------------
M
-
H
T
-
P
I
T
M
L
S
D
---------------------
Q
-
V
R
V
L
I
L
Y
L
I
D
E
I
V
--
H
A
-----
I
H
T
N
S
N
-------------------------
Q
S
N
D
E
L
I
D
G
L
K
P
K
V
R
I
V
I
N
E
F
H
A
T
L
M
M
G
I
------
D
K
M
K
F
Y
S
L
N
E
L
R
E
I
V
N
D
K
I--------------
6
PsiBlast_PDB
56.96
24%
-65
- C7 -
1OKC
7
ADT1_BOVIN
A:
[2-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
----------------
K
D
F
L
A
G
G
-
V
A
A
---
A
I
S
K
-------
T
A
V
A
-----
P
------------
I
E
R
V
K
L
L
L
Q
V
Q
------
H
A
--------
S
KQISAEKQ
Y
K
G
I
I
D
--------
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
--
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
----
F
K
D
K
Y
K
Q
I
F
L
G
G
-
V
D
R
H
K
---
Q
F
W
R
-
Y
F
------
A
G
N
-------------
L
A
S
G
G
-----------
A
A
G
A
T
S
L
C
F
-
V
Y
-
P
L
D
F
A
R
T
---------------------
R
-
L
A
A
D
V
G
K
G
A
A
Q
R
-----------
E
F
T
G
L
G
N
C
-----
I
T
----------
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
------
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
S
----------------
24
HHSearch
56.03
21%
-62
* C7 *
1OKC
8
ADT1_BOVIN
A:
[5-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
L
K
D
F
-
L
A
G
---
G
V
A
A
A
I
S
---
K
T
A
V
A
-----
P
------------
I
E
R
V
K
L
L
L
Q
V
Q
------
H
A
SKQISAEK
Q
--------
Y
K
G
I
I
D
--------
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
--
L
A
N
V
I
R
Y
F
P
T
Q
A
L
-
N
F
----
A
F
K
D
K
Y
K
Q
I
F
L
G
-
G
V
D
R
H
KQ
F
W
--
R
-
Y
F
------
A
G
N
-------------
L
A
S
G
G
-----------
A
A
G
A
T
S
L
C
F
-
V
Y
-
P
L
D
F
A
R
T
---------------------
R
-
L
A
A
D
V
G
K
G
A
------
A
Q
-----
R
E
F
T
G
L
G
N
C
-----
I
T
----------
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
------
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
S
----------------
7
PsiBlast_PDB
54.96
24%
-61
- C7 -
2C3E
4
ADT1_BOVIN
A:
[2-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
----------------
K
D
F
L
A
G
G
-
V
A
A
---
A
I
S
K
-------
T
A
V
A
-----
P
------------
I
E
R
V
K
L
L
L
Q
V
Q
------
H
A
--------
S
KQISAEKQ
Y
K
G
I
I
D
--------
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
--
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
----
F
K
D
K
Y
K
Q
I
F
L
G
G
-
V
D
R
H
K
---
Q
F
W
R
-
Y
F
------
A
G
N
-------------
L
A
S
G
G
-----------
A
A
G
A
T
S
L
C
F
-
V
Y
-
P
L
D
F
A
R
T
---------------------
R
-
L
A
A
D
V
G
K
G
A
A
Q
R
-----------
E
F
T
G
L
G
N
C
-----
I
T
----------
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
------
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
S
----------------
35
Fugue
52.92
16%
-74
* C6 *
3GRE
-
VPS15_YEAST
A:
[1031-1454]
----------------------------ESI
E
K
F
L
S
T
F
I
L
P
P
L
R
D
Y
K
--
E
F
G
P
I
Q
E
I
V
R
S
P
N
M
G
-
N
L
R
G
K
L
I
A
T
L
M
E
N
E
----
P
N
SI
T
S
-
S
A
V
S
P
G
E
T
P
Y
L
I
T
G
S
DQG
V
I
K
I
W
N
L
K
E
I
I
V
G
E
V
Y
S
S
S
----------------
L
T
-
Y
D
C
S
S
T
V
T
Q
I
T
M
I
P
N
-------
F
D
--------------
A
F
A
V
S
S
K
D
G
Q
I
----------------------------
I
V
L
K
V
N
H
Y
Q
Q
---
E
---
S
E
V
K
F
L
N
C
E
C
I
----
R
K
I
N
L
K
N
F
G
K
N
E
Y
A
V
-----
R
M
R
A
F
-----
V
N
E
E
K
S
L
L
-
V
A
-----
L
T
N
L
S
R
---
V
I
I
F
D
---------------------
I
R
T
L
E
R
L
Q
------
I
I
--------
E
--------
N
S
P
R
H
G
--------
A
V
S
S
I
C
I
D
E
E
C
C
V
L
I
L
G
T
TR
G
I
I
D
I
W
D
I
R
F
N
------------
V
L
I
R
S
W
S
F
G
D
H
A
P
I
T
---
H
--
V
-
E
V
C
QFYGK
N
S
V
-------------
I
V
V
G
G
-----------
S
S
K
T
F
L
T
I
W
-
N
F
-
V
K
G
H
C
Q
Y
AFINSDEQPSMEHFLPIEKGL
E
-
E
L
N
F
C
G
I
R
S
L
N
A
L
--
S
T
-----
I
S
V
S
N
D
K
I
L
-----
L
T
D
EATS
S
I
V
M
F
S
L
N
E
L
S
S
S
K
A
V
I
S
P
F
S
D
V
F
I
P
T
Q
V
T
A
N
L
T
M
L
L
R
K
------
M
K
H
D
I
I
N
S
I
S
T
C
E
V
D
E
T
P
L
L
V
A
C
D
NSG
L
I
G
I
F
Q
38
Fugue
52.61
11%
-77
- C2 -
4G9K
1
NDI1_YEAST
A:
[1-471]
--------------------------------
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
--
I
L
G
-
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
-
K
Y
N
V
S
I
I
S
P
R
----
S
Y
--
F
L
F
T
P
L
L
P
S
A
-------------
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
KK
G
N
V
T
Y
Y
E
A
E
A
T
S
I
-
N
P
D
R
N
T
V
T
I
K
S
L
S
A
V
-------
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
-
D
Y
L
I
S
AVGAEPNTFGIPGVTDYGHFLKE
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
---
N
L
L
P
K
G
D
P
E
R
R
----
R
L
L
S
I
V
V
V
G
G
G
P
T
G
V
-----
E
A
A
G
E
-----
L
Q
D
Y
V
H
Q
D
-
L
R
K
---
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
-----
A
LPIVLNMFE
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
------
S
I
--------
K
--------
V
H
L
-
R
T
--------
A
V
A
K
V
E
E
K
Q
L
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
-
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
-
I
P
E
Q
N
---
S
--
S
-
K
R
------
G
L
A
VNDFLQVKGSNN
I
F
A
I
G
D
NAFAGLPPT
A
Q
V
A
H
Q
E
A
E
Y
L
-
A
K
-
N
F
D
K
M
A
Q
---------------------
I
-
P
N
F
Q
K
I
D
L
L
F
E
E
N
--
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
GSE
R
A
I
A
----------
T
I
R
S
G
K
R
T
F
Y
T
G
G
G
-
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
------
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL----------
23
HHSearch
50.12
26%
-48
- C7 -
2LCK
-
UCP2_MOUSE
A:
[113-302]
--------------------------------------
H
A
G
I
G
S
R
L
L
--
A
G
S
-
T
T
G
A
L
A
V
A
V
A
Q
-
P
T
D
-
V
V
K
V
R
F
Q
A
Q
A
----
R
A
--
G
G
-------------------------------------------------------------------------------
G
R
--------------
R
Y
Q
S
T
V
-
E
A
Y
K
----------------------------
T
I
A
R
E
E
G
I
R
G
L
W
K
G
---
T
S
P
N
V
A
R
N
A
I
V
----
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
L
-----
L
K
A
N
L
M----
T
D
D
L
P
C
H
F
-
T
S
A
---
F
G
A
G
F
C
T
---
T
V
I
A
S
-----
P
------------
V
D
V
V
K
T
R
Y
M
N
S
------
A
L
G-------
Q
--------
Y
H
S
A
G
H
--------
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
--
M
P
S
F
L
R
L
G
S
W
N
V
V
-
M
F
----
V
T
Y
E
Q
L
K
R
A
L
M
A
-
A
Y
Q
S
R
---
E
--
A
-
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.75
33%
-64
* C8 *
4R7A
1
RBBP4_HUMAN
B:
[126-167]
-------------------------------------------------------------------
E
-
V
N
R
A
R
Y
M
P
Q
N
----
P
C
--
I
I
-
A
T
K
T
P
S
S
-------------
D
V
L
V
F
D
Y
T
K
H
P
S
K
P
D
P
S
G
E
C
----
N
P
D
L
R
L
R
G
H
Q
K
-
E
G
Y
G
L
S
W
N
P
N
L
S
G
H
L
-------
L
S
--------------
A
S
D
D
H
T
-
I
C
L
W
----------------------------
D
I
S
A
V
P
K
E
G
K
V
V
D
A
---
K
T
I
F
T
G
H
T
A
V
V
----
E
D
V
S
W
H
L
L
H
E
S
L
F
G
S
-----
V
A
D
D
Q
-----
K
L
M
I
W
D
T
R
-
S
N
N
---
T
S
K
P
S
H
S
---
V
D
A
H
T
-----
A
------------
E
V
N
C
L
S
F
N
P
Y
S
------
E
F
--------
I
--------
L
A
T
G
S
A
--------
D
K
T
V
A
L
W
D
L
R
N
L
K
L
K
L
H
S
--
F
E
S
H
K
D
E
I
F
Q
V
Q
W
-
S
P
----
H
N
E
T
I
L
A
S
S
G
T
D
-
R
R
L
N
V
---
W
--
D
-
L
S
------
K
I
G
-------------
E
E
A
E
D
-----------
G
P
P
E
L
L
F
I
H
-
G
G
-
H
T
A
K
I
S
D
---------------------
F
-
S
W
N
P
N
E
P
W
V
I
C
S
V
--
S
E
-----
D
N
I
M
Q
V
W
Q
M
-----
A
E
----------
N
I
Y
N
---------------------------------------------------------------------
12
PsiBlast_PDB
46.56
33%
-77
- C8 -
4PBY
1
RBBP4_HUMAN
A:
[126-167]
-------------------------------------------------------------------
E
-
V
N
R
A
R
Y
M
P
Q
N
----
P
C
--
I
I
-
A
T
K
T
P
S
S
-------------
D
V
L
V
F
D
Y
T
K
H
P
S
K
P
D
P
S
G
E
C
----
N
P
D
L
R
L
R
G
H
Q
K
-
E
G
Y
G
L
S
W
N
P
N
L
S
G
H
L
-------
L
S
--------------
A
S
D
D
H
T
-
I
C
L
W
----------------------------
D
I
S
A
V
P
K
E
G
K
V
V
D
A
---
K
T
I
F
T
G
H
T
A
V
V
----
E
D
V
S
W
H
L
L
H
E
S
L
F
G
S
-----
V
A
D
D
Q
-----
K
L
M
I
W
D
T
R
-
S
N
N
---
T
S
K
P
S
H
S
---
V
D
A
H
T
-----
A
------------
E
V
N
C
L
S
F
N
P
Y
S
------
E
F
--------
I
--------
L
A
T
G
S
A
--------
D
K
T
V
A
L
W
D
L
R
N
L
K
L
K
L
H
S
--
F
E
S
H
K
D
E
I
F
Q
V
Q
W
-
S
P
----
H
N
E
T
I
L
A
S
S
G
T
D
-
R
R
L
N
V
---
W
--
D
-
L
S
------
K
I
G
-------------
E
E
Q
S
P
-----------
E
D
A
E
D
G
P
P
E
-
L
L
-
F
I
H
G
G
H
T
---------------------
A
-
K
I
S
D
F
S
W
N
P
N
E
P
W
--
V
I
-----
C
S
V
S
E
D
N
I
M
-----
Q
V
----------
W
Q
M
A
E
N
I
Y
N
D
---------------------------------------------------------------