@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2541_HUMAN: (2015-12-09 )
MGAQPGEPQNTCSRIQTLFRRVKTLLIKAPPPPQPPPPPPSWNPGCTHVYGYAFGHMHDNNLEHLPSQQVLDTGEQLMVPVEVLEVDNKEALWKFLLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLWRGNGINVLKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQERLLAGSLAVAISQTLINPMEVLKTRLTLRRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTLGI
Atome Classification :
(20 SA)
--------------------------.......-------..10.....-----...---20....-----....30----------.-------------...--....40-----......-------...-50....----....60---........70------...--......--80--------------------..-..----..-------------------...--------------------90......------.----.100.......-110--------.....---...120---------..------.-------.----.---------..130......---.140.-----....-------.--..150--.......-----160-----..----...--..---------------------------..170.--....-..-----180--.-----...-----....190....----...200-------........210..-----.--.-----.-----..---220---....--.....-----230......-.-240....-...250-..-----..-....----.260...---....270.....------..-280.....-..290.......---300.....-----..310.....---..320---.-....---..330---....-..--.----340..--.----....350--...--------.-.-----..360-.........370-------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------MGAQPGE-------P
Q
N
T
C
S
R
I
Q
-----
T
L
F
---
R
R
V
K
T
L
-----
L
I
KAPP----------P-------------PQP--PPPPP------SWNPGC-------
T
H
V
-
Y
G
Y
A
FG----HMHDN
N
---
L
E
HL
P
S
Q
Q
V
-------LDT--GE
Q
L
M
V
--
P
---------------------
V
E
-
V
L
----EV-------------------D
N
K
--------------------
E
A
L
W
K
F
L
L
------
S
----
G
A
MAGAVSRTG-TA---------
P
L
D
R
A
---
K
V
Y
M
Q
V
---------YS------S-------K----T---------
N
F
T
N
L
L
G
G
L
Q
S
---
M
V
-
Q
E-----GG
F
R
-------
S
--LWRGN--G
I
N
V
L
K
I-----A-------PE----
Y
A
I
--
K
F
---------------------------
S
V
F
E
Q
C
--
K
N
Y
F-CG-----IQ---G-----SP
P
-----
F
Q
E
R
L
L
A
G
S
L
A
----
V
A
I
S
Q
--------
T
LI
N
P
M
E
V
L
K
T
R
L
-----
T
--L-----R-----RT---G-----QYK
G
--
L
L
D
C
A
-----
R
Q
I
L
Q
REG
T
-
R
-
A
L
Y
R
GYL-
P
N
M
L
---GI-----IP-YAC
T
----
D
L
A
V
Y
E
M
---
L
Q
C
F
WVKSGRDM------GD-PSG
L
V
S
L
S
-
S
V
T
L
STTCGQMA---SY
P
L
T
L
V
R
-----
T
R
M
QAQDTVE---GSN
P
T
---
M
-
R
G
V
L
---
Q
R
I
L
A
---QQG
W
-
L
G
--
L
----YRGM
T
--
P
----
T
L
L
K
VLP--AG
G
--------
I
-
S
-----
Y
V
V
---
Y
E
A
M
K
K
T
LGI---------------------------------------------------------------------------
15
HHSearch
86.20
27%
-59
- C4 -
1OKC
10
ADT1_BOVIN
A:
[3-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
--------------------
L
S
F
L
K
D
F
L
------
A
----
G
G
V
A
A
A
I
S
K
T
A
-
V
A
---------
P
I
E
R
V
---
K
L
L
L
Q
V
---------
Q
H
------
A
-------
S
----
K
QISAEK---
Q
Y
K
G
I
I
D
C
V
V
R
---
I
P
-
K
E
-----
Q
G
F
L
-------
S
--
F
W
R
G
N
--
L
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
Y
--
K
Q
I
F
-
L
G
-----
G
V
---
D
RHKQ
F
W
R
Y
-----
F
A
G
N
L
A
S
G
G
A
A
----
G
A
T
S
L
--------
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
--
A
-----
D
-----
V
G
---
K
GAAQR
E
F
T
G
--
L
G
N
C
I
-----
T
K
I
F
K
S
D
G
L
-
R
-
G
L
Y
Q
G
F
N
-
V
S
V
Q
---
G
I
-----
I
I
-
Y
R
A
A
----
Y
F
G
V
Y
D
T
---
A
K
G
M
L
P
D
P
K
----------
N
-
V
H
I
I
V
S
W
M
-
I
A
Q
T
V
T
A
V
A
G
L
V
---
S
Y
P
F
D
T
V
R
-----
R
R
M
M
M
Q
S
G
R
K
GAD
I
M
Y
T
G
---
T
-
V
D
C
W
---
R
K
I
A
K
---
D
E
G
P
-
K
A
--
F
----
F
K
G
A
W
--
S
----
N
V
L
R
G
M
G
---
G
A
--------
F
-
V
-----
L
V
L
---
Y
D
E
I
---------------------------------------------------------------------------------
24
Fugue
83.83
26%
-71
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
--------------------
L
S
F
L
K
D
F
L
------
A
----
G
G
V
A
A
A
I
S
K
T
A
-
V
A
---------
P
I
E
R
V
---
K
L
L
L
Q
V
---------
Q
H
ASKQIS
A
-------
E
----
K
---------
Q
Y
K
G
I
I
D
C
V
V
R
---
I
P
-
K
E
-----
Q
G
F
L
-------
S
--
F
W
R
G
N
--
L
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
Y
--
K
Q
I
F
-
L
G
-----
G
V
---
D
-----
R
H
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
----
G
A
T
S
L
--------
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
--
A
DVGKG
A
-----
A
Q
---
R
-----
E
F
T
G
--
L
G
N
C
I
-----
T
K
I
F
K
S
D
G
L
-
R
-
G
L
Y
Q
G
F
N
-
V
S
V
Q
---
G
I
-----
I
I
-
Y
R
A
A
----
Y
F
G
V
Y
D
T
---
A
K
G
M
L
P
D
P
K
----------
N
-
V
H
I
I
V
S
W
M
-
I
A
Q
T
V
T
A
V
A
G
L
V
---
S
Y
P
F
D
T
V
R
-----
R
R
M
M
M
Q
S
G
R
K
---
G
A
D
I
M
YTG
T
-
V
D
C
W
---
R
K
I
A
K
---
D
E
G
P
-
K
A
--
F
----
F
K
G
A
W
--
S
----
N
V
L
R
G
M
G
--
G
A
---------
F
-
V
-----
L
V
L
---
Y
D
E
I
---------------------------------------------------------------------------------
2
PsiBlast_PDB
81.85
26%
-68
- C4 -
2C3E
4
ADT1_BOVIN
A:
[2-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
--------------------
L
S
F
L
K
D
F
L
------
A
----
G
G
V
A
A
A
I
S
K
T
A
-
V
A
---------
P
I
E
R
V
---
K
L
L
L
Q
V
QHASKQ---
I
S
------
A
-------
E
----
K
---------
Q
Y
K
G
I
I
D
C
V
V
R
---
I
P
-
K
E
-----
Q
G
F
L
-------
S
--
F
W
R
G
N
--
L
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
Y
--
K
Q
I
F
-
L
G
GVDRH
K
Q
---
F
-----
W
R
Y
-----
F
A
G
N
L
A
S
G
G
A
A
----
G
A
T
S
L
--------
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
--
A
-----
D
VGKGA
A
Q
---
R
-----
E
F
T
G
--
L
G
N
C
I
-----
T
K
I
F
K
S
D
G
L
-
R
-
G
L
Y
Q
G
F
N
-
V
S
V
Q
---
G
I
-----
I
I
-
Y
R
A
A
----
Y
F
G
V
Y
D
T
---
A
K
G
M
-------
L
------
P
D
-
P
K
N
V
H
I
I
V
-
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
-----
R
R
M
M
M
Q
S
G
R
K
---
G
A
D
I
M
---
Y
-
T
G
T
V
D
C
W
R
K
I
A
K
---
D
E
G
P
-
K
A
--
F
----
F
K
G
A
W
--
S
----
N
V
L
R
G
M
---
G
G
A
--------
F
-
V
-----
L
V
L
---
Y
D
E
I
---------------------------------------------------------------------------------
1
PsiBlast_PDB
80.68
26%
-70
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
A
--------------------
L
S
F
L
K
D
F
L
------
A
----
G
G
V
A
A
A
I
S
K
T
A
-
V
A
---------
P
I
E
R
V
---
K
L
L
L
Q
V
QHASKQ---
I
S
------
A
-------
E
----
K
---------
Q
Y
K
G
I
I
D
C
V
V
R
---
I
P
-
K
E
-----
Q
G
F
L
-------
S
--
F
W
R
G
N
--
L
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
Y
--
K
Q
I
F
-
L
G
GVDRH
K
Q
---
F
-----
W
R
Y
-----
F
A
G
N
L
A
S
G
G
A
A
----
G
A
T
S
L
--------
C
F
V
Y
P
L
D
F
A
R
T
R
L
-----
A
--
A
-----
D
VGKGA
A
Q
---
R
-----
E
F
T
G
--
L
G
N
C
I
-----
T
K
I
F
K
S
D
G
L
-
R
-
G
L
Y
Q
G
F
N
-
V
S
V
Q
---
G
I
-----
I
I
-
Y
R
A
A
----
Y
F
G
V
Y
D
T
---
A
K
G
M
-------
L
------
P
D
-
P
K
N
V
H
I
I
V
-
S
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
T
V
R
-----
R
R
M
M
M
Q
S
G
R
K
---
G
A
D
I
M
---
Y
-
T
G
T
V
D
C
W
R
K
I
A
K
---
D
E
G
P
-
K
A
--
F
----
F
K
G
A
W
--
S
----
N
V
L
R
G
M
---
G
G
A
--------
F
-
V
-----
L
V
L
---
Y
D
E
I
---------------------------------------------------------------------------------
5
PsiBlast_PDB
79.32
24%
-66
- C4 -
4C9Q
5
ADT3_YEAST
A:
[31-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
------
M
----
G
G
V
S
A
A
I
A
K
T
A
-
A
S
---------
P
I
E
R
V
---
K
I
L
I
Q
N
---------
Q
D
------
E
M
I
K
Q
GTL
D
----
K
---------
K
Y
S
G
I
V
D
C
F
K
R
---
T
A
-
K
Q
-----
E
G
L
I
-------
S
--
F
W
R
G
N
--
T
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
I
--
K
L
M
F
--
G
-----
F
K
---
K
-----
E
-
G
Y
G
K
W
-
F
A
G
N
L
A
S
G
G
A
A
----
G
A
L
S
L
--------
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
DAK
S
--------------------AR---
Q
F
N
G
--
L
T
D
V
Y
-----
K
K
T
L
K
S
D
G
I
-
A
-
G
L
Y
R
G
F
M
-
P
S
V
V
---
G
I
-----
V
V
-
Y
R
G
L
----
Y
F
G
M
F
D
S
---
L
K
P
L
-------------------
F
L
A
S
F
L
-
L
G
W
V
V
T
T
G
A
S
T
C
---
S
Y
P
L
D
T
V
R
-----
R
R
M
M
M
T
S
G
Q
A
---
V
K
Y
N
G
---
A
-
I
D
C
L
---
K
K
I
V
A
---
S
E
G
V
-
G
S
--
L
----
F
K
G
C
G
--
A
----
N
I
L
R
S
V
A
--
G
A
G
--------
V
-
I
-----
S
M
Y
---
D
Q
L
Q
M
I
L
F
G
K
---------------------------------------------------------------------------
3
PsiBlast_PDB
75.50
25%
-66
- C4 -
4C9H
5
ADT2_YEAST
A:
[27-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
------
M
----
G
G
V
S
A
A
V
A
K
T
A
-
A
S
---------
P
I
E
R
V
---
K
L
L
I
Q
N
---------
Q
D
------
E
M
L
K
Q
GTL
D
----
R
---------
K
Y
A
G
I
L
D
C
F
K
R
---
T
A
-
T
Q
-----
E
G
V
I
-------
S
--
F
W
R
G
N
--
T
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
I
--
K
A
M
F
--
G
-----
F
K
---
K
-----
E
E
G
Y
A
K
W
-
F
A
G
N
L
A
S
G
G
A
A
----
G
A
L
S
L
--------
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
DS----------------------AR---
Q
F
N
G
--
L
I
D
V
Y
-----
K
K
T
L
K
S
D
G
V
-
A
-
G
L
Y
R
G
F
L
-
P
S
V
V
---
G
I
-----
V
V
-
Y
R
G
L
----
Y
F
G
M
Y
D
S
---
L
K
----------------------
L
A
S
F
L
-
L
G
W
V
V
T
T
G
A
S
T
C
---
S
Y
P
L
D
T
V
R
-----
R
R
M
M
M
T
S
G
Q
A
---
V
K
Y
D
G
---
A
-
F
D
C
L
---
R
K
I
V
A
---
A
E
G
V
-
G
S
--
L
----
F
K
G
C
G
--
A
----
N
I
L
R
G
V
A
--
G
A
G
--------
V
-
I
-----
S
M
Y
---
D
Q
L
Q
M
I
L
F
G
K
---------------------------------------------------------------------------
32
Fugue
74.61
17%
-87
* C3 *
5AHR
1
A:
[1-343]
-----------------------------------------
S
M
T
C
P
F
Y
K
-----
K
I
P
---
G
T
--
G
F
-----
T
V
D
A
F
Q
----------
Y
-------------
G
V
V
--
E
--------------
G
C
-------
T
----
A
Y
F
L
T
----
H
F
H
S
D
H
---
Y
A
G
L
S
K
H
F
T
-------
F
------------
P
---------------------
V
Y
-
C
S
----
E
I
-------------------
T
G
N
--------------------
L
L
K
N
K
L
H
V
------
Q
----
E
Q
Y
I
H
P
L
P
L
D
T
-
E
C
---------
I
V
N
G
V
---
K
V
V
L
L
D
---------
A
N
------
H
-------
C
----
P
---------
G
A
V
M
I
L
F
Y
L
P
N
G
T
V
I
L
-
H
T
-----
G
D
F
R
A
D
P
S
M
E
R
S
--
L
L
A
D
Q
--
K
V
H
M
L
Y
L
DTTYC
S
-------
P
E
----
Y
T
F
P
S
Q
Q
---------------------------
E
V
I
R
F
A
--
I
N
T
A
-
F
E
-----
A
V
---
T
-----
L
N
P
------
H
A
L
V
V
C
G
T
Y
S
----
I
G
K
E
K
--------
V
F
L
A
I
A
D
V
L
G
S
K
V
-----
G
--
M
------------
S
---
Q
-----
E
K
Y
K
--
T
L
Q
C
--------
L
N
I
P
E
I
N
-
S
-
L
I
T
T
D
M
C
-
S
S
L
V
---
H
L
-----
L
P
-
M
M
Q
I
----
N
---
F
K
G
---
L
Q
S
H
L
K
K
C
G
---------
G
K
-
Y
N
Q
I
L
A
F
R
-
P
T
V
I
P
Q
T
K
G
N
I
S
---
I
Y
G
I
P
Y
--------------
S
E
H
---
S
S
Y
L
E
---
M
-
K
R
F
V
---
Q
W
L
K
P
---
Q
----------------------------
K
I
I
P
--
T
V
N
--------
V
G
T
-----
W
K
S
---
R
S
T
M
E
K
Y
F
R
E
W
K
L
E
A
GY--------------------------------------------------------------------
4
PsiBlast_PDB
74.58
24%
-64
- C4 -
4C9J
4
ADT3_YEAST
A:
[31-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
------
M
----
G
G
V
S
A
A
I
A
K
T
A
-
A
S
---------
P
I
E
R
V
---
K
I
L
I
Q
N
---------
Q
D
------
E
M
I
K
Q
GTL
D
----
K
---------
K
Y
S
G
I
V
D
C
F
K
R
---
T
A
-
K
Q
-----
E
G
L
I
-------
S
--
F
W
R
G
N
--
T
A
N
V
I
R
Y
-----
F
-------
P
T
----
Q
A
L
--
N
F
---------------------------
A
F
K
D
K
I
--
K
L
M
F
--
G
-----
F
K
---
K
-----
E
E
G
Y
G
K
W
-
F
A
G
N
L
A
S
G
G
A
A
----
G
A
L
S
L
--------
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
DAK
S
--------------------AR---
Q
F
N
G
--
L
T
D
V
Y
-----
K
K
T
L
K
S
D
G
I
-
A
-
G
L
Y
R
G
F
M
-
P
S
V
V
---
G
I
-----
V
V
-
Y
R
G
L
----
Y
F
G
M
F
D
S
---
L
K
-------------------------
F
L
-
L
G
W
V
V
T
T
G
A
S
T
C
---
S
Y
P
L
D
T
V
R
-----
R
R
M
M
M
T
S
G
Q
A
---
V
K
Y
N
G
---
A
-
I
D
C
L
---
K
K
I
V
A
---
S
E
G
V
-
G
S
--
L
----
F
K
G
C
G
--
A
----
N
I
L
R
S
V
A
--
G
A
G
--------
V
-
I
-----
S
M
Y
---
D
Q
L
Q
M
I
L
F
G
K
---------------------------------------------------------------------------
25
Fugue
66.64
15%
-51
* C2 *
5A1F
9
KDM5B_HUMAN
A:
[1-458]
------------------------SM
F
L
P
P
P
E
C
-------
P
V
F
E
P
S
W
E
E
FAD
P
F
A
F
I
---
H
K
I
R
P
I
A
E
Q
T
G
I
C
K
V
R
P
----------
P
-------------
P
D
W
--
Q
P
P
F
A
C
D
VDK
L
H
F
T
P
R
I
-------
Q
R
L
N
E
L
E
A
Q
T
----
R
V
R
D
Y
T
---
L
R
T
F
G
E
M
A
D
-------
A
F
K
--
S
D
Y
F
N
M
--
P
---------------------
V
H
M
V
P
----
T
E
-------------------
L
V
E
--------------------
K
E
F
W
R
L
V
S
------
T
----
I
E
E
D
V
T
V
E
Y
G
A
-
D
I
A
SKEFGSG
F
P
V
R
D
S
---
P
E
E
E
E
Y
---------
L
D
------
S
-------
G
----
W
---------
N
L
N
N
M
P
V
M
E
Q
S
---
V
L
-
A
H
ITADI
C
G
M
K
-------
L
P
W
L
Y
V
G
M
--
C
F
S
S
F
C
W
-----
H
-------
I
E
DHW
S
Y
S
I
--
N
Y
---------------------------
L
H
W
G
E
P
--
K
T
W
Y
G
V
P
-----
G
Y
---
A
-----
A
E
Q
-----
L
E
N
V
M
K
K
L
A
P
E
----
L
F
V
S
Q
PDLL
H
Q
L
V
T
I
M
N
P
N
T
L
M
T
H
E
V
-----
P
--
V
-----
Y
-----
R
T
---
N
-----
Q
C
A
G
E
F
V
I
T
F
P
-----
R
-
A
Y
H
S
G
F
N
-
Q
-
G
F
N
F
A
E
A
-
V
N
F
C
---
T
V
DW---
L
P
-
L
G
R
Q
----
C
V
E
H
Y
R
L
---
L
H
R
Y
C
V
F
S
H
D
E
M
---------
I
C
K
M
A
S
K
A
-
D
V
L
D
V
V
V
A
S
T
V
Q
---
K
D
M
A
I
M
I
E
-----
D
E
K
A
L
R
E
T
V
R
---
K
L
G
V
I
---
D
-
S
E
R
M
---
D
F
E
L
L
---
P
D
D
E
-
R
Q
--
C
----
V
K
C
K
T
--
T
----
C
F
M
S
A
I
S
--
C
S
C
--------
K
-
P
G
L
---
L
V
C
---
L
H
H
V
K
E
L
C
S
C
PPYKYKLRYRYT
L
D
D
L
Y
P
M
M
N
A
L
K
L
R
A
E-----------------------------------------------
33
Fugue
64.61
17%
-62
- C3 -
4J1Q
1
A:
[20-445]
-----------------H
M
E
R
L
M
L
E
P
V
W
E
K
Q
N
E
-------
E
L
S
Y
T
E
H
I
I
-----
V
L
F
ETE
R
S
V
T
D
S
-----
I
A
S
H
M
K
----------
D
-------------
A
R
V
--
I
T
L
N
E
------
A
V
G
H
I
A
-------
E
R
Y
-
Q
C
Y
M
Q
N
I
F
--
E
L
L
Q
S
K
---
V
R
K
L
S
A
G
R
I
I
I
Q
A
I
V
P
L
E
K
--
E
K
Q
L
F
A
--
G
---------------------
V
S
-
G
L
F
K
T
A
E
I
-------------------
E
F
S
--------------------
K
L
T
A
Q
V
I
E
I
EKPEE
M
----
I
D
L
H
L
K
L
K
D
D
S
-
R
R
---------
P
F
D
K
Q
---
I
R
Y
E
A
G
---------
Y
R
------
F
-------
V
----
K
---------
G
W
R
E
M
V
D
T
L
H
M
---
P
W
-
R
D
-----
E
G
V
Y
-------
L
--
I
T
G
G
A
--
G
S
L
G
L
L
F
-----
A
-------
K
E
----
I
A
N
--
R
T
---------------------------
G
---
R
S
--
T
I
V
L
-
T
G
-----
R
S
---
V
-----
L
S
E
-----
D
K
E
N
E
L
E
A
L
R
S
I
G
A
E
V
V
Y
R
E
--------
A
D
V
S
D
Q
H
A
V
R
H
L
L
-----
E
E
I
K
-----
E
-----
R
Y
---
G
-----
T
L
N
G
--
I
I
H
G
A
G
S
S
K
D
R
F
I
I
H
K
--
T
-
N
-
E
E
F
Q
E
V
L
Q
P
K
V
S
---
G
L
-----
L
H
V
D
E
C
S
----
K
D
F
P
L
D
F
---
F
I
F
F
S
S
V
S
G
C
L
-------
G
N
-
A
G
---
Q
A
D
-
Y
A
A
A
N
S
F
M
D
A
F
A
---
E
Y
R
R
S
L
A
A
-----
S
K
K
R
F
G
S
T
I
S
---
F
N
W
P
L
---
W
E
E
G
G
M
---
Q
V
G
A
E
---
D
E
K
R
-
M
L
--
K
----
T
T
G
M
V
--
P
MP
T
D
S
G
L
K
A
F
Y
--
Q
G
I
--------
V
-
S
DKP
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
L
L
----------------------------------------------------------------------------
6
PsiBlast_PDB
64.34
24%
-63
- C4 -
2LCK
-
UCP2_MOUSE
A:
[16-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
L
G
------
A
----
G
T
-
A
A
C
I
A
D
L
I
-
T
F
---------
P
L
D
T
A
---
K
V
R
L
Q
I
QGESQG
L
V
R
T
A
------
A
-------
S
----
A
---------
Q
Y
R
G
V
L
G
T
I
L
T
---
M
V
-
R
T
-----
E
G
P
R
-------
S
--
L
Y
N
G
L
--
V
A
G
L
Q
R
Q
-----
M
-------
S
F
----
A
S
V
--
R
I
---------------------------
G
L
Y
D
S
V
--
K
Q
F
Y
-
T
K
-----
G
S
---
E
-----
H
A
G
-----
I
G
S
R
L
L
A
G
S
T
T
----
G
A
L
A
V
--------
A
V
A
Q
P
T
D
V
V
K
V
R
F
-----
Q
--
A
-----
Q
A----
R
A
---
G
GGR--
R
Y
Q
S
--
T
V
E
A
Y
-----
K
T
I
A
R
E
E
G
I
-
R
-
G
L
W
K
G
T
S
-
P
N
V
A
---
R
N
-----
A
I
-
V
N
C
A
----
E
L
V
T
Y
D
L
---
I
K
D
T
L
L
K
A
N
L
M
T
------
D
D
L
P
C
H
F
T
S
A
F
-
G
A
G
F
C
T
T
---
V
I
---
A
S
P
V
D
V
V
K
-----
T
R
Y
--
M
N
S
A
L
---
G
Q
Y
H
S
---
A
-
G
H
C
A
---
L
T
M
L
R
---
K
E
G
P
-
R
A
--
F
----
Y
K
G
F
M
--
P
----
S
F
L
R
L
G
S
--
W
N
V
--------
V
-
M
-----
F
V
T
---
Y
E
Q
L
K
R
A
L
M
A
---------------------------------------------------------------------------
14
HHSearch
63.79
23%
-61
- C4 -
2LCK
-
UCP2_MOUSE
A:
[14-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
F
L
------
G
----
A
G
T
A
A
C
I
A
D
L
I
-
T
F
---------
P
L
D
T
A
---
K
V
R
L
Q
I
---------
Q
G
------
E
-------
S
----
Q
G
L
V
R
T
A
ASA
Q
Y
R
G
V
L
G
T
I
L
T
---
M
V
-
R
T
-----
E
G
P
R
-------
S
--
L
Y
N
G
L
--
V
A
G
L
Q
R
Q
-----
M
-------
S
F
----
A
S
V
--
R
I
---------------------------
G
L
Y
D
S
V
--
K
Q
F
Y
-
T
K
-----
G
S
---
E
-----
H
A
G
-----
I
G
S
R
L
L
A
G
S
T
T
----
G
A
L
A
V
--------
A
V
A
Q
P
T
D
V
V
K
V
R
F
-----
Q
--
A
-----
Q
-----
A
R
---
A
GGGR-
R
Y
Q
S
--
T
V
E
A
Y
-----
K
T
I
A
R
E
E
G
I
-
R
-
G
L
W
K
G
T
S
-
P
N
V
A
---
R
N
-----
A
I
-
V
N
C
A
----
E
L
V
T
Y
D
L
---
I
K
D
T
L
L
K
A
N
L
M
--------
T
-
D
D
L
P
C
H
F
T
-
S
A
F
G
A
G
F
C
T
T
V
I
---
A
S
P
V
D
V
V
K
-----
T
R
Y
M
N
S
A
L
-----
G
Q
Y
H
S
---
A
-
G
H
C
A
---
L
T
M
L
R
---
K
E
G
P
-
R
A
--
F
----
Y
K
G
F
M
--
P
----
S
F
L
R
L
G
S
--
W
N
V
--------
V
-
M
-----
F
V
T
---
Y
E
Q
L
K
R
A
L
M
A
---------------------------------------------------------------------------
30
Fugue
63.32
15%
-58
- C1 -
3J9O
-
?
B:
[79-505]
--------------------------
V
I
D
K
L
I
D
-------
L
Q
V
N
S
I
I
S
N
-----
D
E
F
---
R
A
L
E
Q
E
-----
W
L
K
V
Q
E
----------
V
-------------
C
Q
E
DY
D
N
V
E
V
------
S
I
L
D
V
K
-------
K
E
E
-
L
Q
Y
D
F
E
R
N
L
Y
D
I
S
S
S
D
---
F
F
K
K
V
Y
V
S
E
-------
F
D
Q
YG
G
E
P
Y
G
A
--
I
---------------------
L
G
-
L
Y
----
N
F
-------------------
E
N
T
--------------------
T
N
D
I
I
W
L
T
------
G
----
M
G
M
V
A
K
N
S
H
A
P
F
I
A
---------
S
I
D
K
S
FFG
V
K
D
L
S
E
---------
I
T
------
H
-------
I
----
K
---------
S
F
E
A
L
L
E
H
-
P
R
---
Y
K
-
E
W
-----
N
D
F
R
-------
N
--
L
D
V
A
A
Y
I
G
L
T
V
G
D
F
-----
M
LRQPYNP
E
N
----
N
P
V
--
Q
Y
---------------------------
K
L
M
E
G
F
--
N
E
F
V
-
D
Y
-----
D
K
---
N
-----
E
S
Y
----------
L
W
G
P
A
S
----
I
H
L
V
K
--------
N
M
M
R
S
Y
D
K
T
R
W
F
Q
-----
Y
--
I
-----
R
-----
G
V
ESG
G
-----
Y
V
K
N
--
L
V
A
C
V
Y
D
N--
K
G
I
L
E
T
K
S
P
L
N
-
V
L
F
A
D
Y
M
-
E
L
S
L
A
N
I
G
L
-----
I
P
-
F
V
S
E
KGTS
N
A
C
F
F
S
V
---
N
S
A
K
K
V
E
E
F
V
D
G
------
F
D
-
S
A
N
S
R
L
I
A
-
N
L
S
Y
T
M
C
I
S
R
I
S
---
H
Y
I
K
C
V
I
R
-----
D
K
I
G
S
I
V
D
V
E
---
S
I
Q
K
I
---
L
-
S
D
W
I
---
S
E
F
V
T
TVY
Q
P
T
P
-
L
E
--
M
ARYP
F
R
N
V
S
--
I
----
E
V
K
T
I
P
G
--
K
P
G
W
Y
S
C
K
I
N
V
I
-
P
-----
H
I
Q
---
F
E
G
M
N
T
T
M
T
I
DTRLEPELFGTNN--------------------------------------------------------------
29
Fugue
62.53
16%
-75
* C5 *
4Y21
-
?
A:
[1-539]
G
K
E
R
F
V
K
L
L
D
Q
L
H
N
S
L
R
I
D
L
S
M
YRNN
F
P
A
S
S
P
E
-------
R
L
Q
D
L
K
S
T
V
-----
D
L
L
---
T
S
I
T
F
F
-----
R
M
K
V
Q
E
----------
L
-------------
Q
S
P
--
P
R
A
S
Q
------
V
V
K
D
C
V
-------
K
A
C
-
L
N
S
T
Y
E
----
Y
I
F
N
N
C
---
H
E
L
Y
G
R
E
Y
Q
-------
T
D
P
--
A
K
K
G
E
V
--
P
PEEQGPSIKNL
D
F
W
S
K
L
I
T
L
I
V
S
-
I
I
----
E
E
-------------------
D
K
N
S
Y
T
P
C
L
NQFPQELN
V
G
K
I
S
A
E
V
M
W
S
-
L
F
------
A
----
Q
D
M
K
Y
A
M
E
E
H
D
-
K
H
---------
R
L
C
K
S
---
A
D
Y
M
N
L
H
--------
F
K
------
V
-------
K
----
W
---------
L
Y
N
E
Y
V
A
E
L
P
T
---
F
K
D
R
V
-----
P
E
Y
P
-------
A
--
W
F
E
P
F
--
V
I
Q
W
L
D
E
-----
N
-------
E
E
----
V
S
R
--
D
F
L
H
G
A
L
E
R
D
K
K
D
GFQQTSEHALFS
C
S
V
V
D
V
F
S
Q
L
--
N
Q
S
F
-
E
I
-----
I
K
K
L
E
C
-----
P
D
P
-----
Q
I
V
G
H
Y
M
R
R
F
A
----
K
T
I
S
N
--------
V
L
L
Q
Y
A
D
I
V
S
K
D
F
-----
A
--
S
-----
Y
-----
C
S
---
K
-----
E
K
E
K
--
V
P
C
I
L
-----
M
N
N
T
Q
Q
--------
L
R
V
Q
L
-
E
K
M
F
---
E
A
-----
M
G
-
G
K
E
L
----
D
A
E
A
S
G
T
---
L
K
E
L
Q
V
K
L
N
N
V
L
------
D
E
-
L
S
H
V
F
A
T
S
F
Q
P
H
I
E
E
C
V
R
Q
M
G
---
D
I
L
S
Q
V
K
G
-----
T
G
N
V
P
A
S
A
C
S
---
S
V
A
Q
D
---
A
-
D
N
V
L
---
Q
P
I
M
D
L
--
L
D
S
N
-
L
T
--
L
----
F
A
K
I
C
--
E
----
K
T
V
L
K
R
V
--
L
K
E
--------
L
-
W
-----
K
L
V
---
M
N
T
M
E
R
T
I
V
L
P
P
E
F
S
KLKD
H
M
V
R
E
E
AKSLT
P
K
Q
C
A
V
V
E
L
A
L
D
T
I
K
Q
Y
F
H
AGGVGLK
K
T
F
L
E
K
S
P
D
L
Q
S
L
R
Y
A
L
S
L
Y
T
QATDLLIK
17
HHSearch
60.09
20%
-39
- C4 -
1OKC
10
ADT1_BOVIN
A:
[26-293]
------------------------------------------------------
A
P
I
---
E
R
V
K
L
L
-----
L
Q
V
Q
H
A
SKQISAEKQY
K
-------------
G
I
I
--
D
C
V
V
R
------
I
P
K
E
Q
---------
G
F
-
L
S
F
W
R
G
----
N
L
A
N
V
I
---
R
Y
F
P
T
Q
A
L
N
-------
F
A
F
--
K
D
K
Y
K
Q
I
F
L
---------------------
G
G
-
V
D
R---
H
K
-------------------
Q
F
W
--------------------
R
Y
F
A
G
N
L
A
------
S
----
G
G
A
A
G
A
T
S
L
C
F
-
V
Y
---------
P
L
D
F
A
---
R
T
R
L
A
A
---------
D
V
------
G
-------
K
GAAQ
R
---------
E
F
T
G
L
G
N
C
I
T
K
---
I
F
-
K
S
-----
D
G
L
R
-------
G
--
L
Y
Q
G
F
--
N
V
S
V
Q
G
I
-----
I
-------
I
Y
----
R
A
A
--
Y
F
---------------------------
G
V
Y
D
T
A
--
K
G
M
L
-
P
D
-----
P
K
---------
N
V
H
-----
I
I
V
S
W
M
I
A
Q
T
V
----
T
A
V
A
G
--------
L
V
S
Y
P
F
D
T
V
R
R
R
M
-----
M
--
M
-----
Q
-----
S
G
---
R
KGADI
M
Y
T
G
--
T
V
D
C
W
-----
R
K
I
A
K
D
E
G
P
-
K
-
A
F
F
K
G
A
W
-
S
N
V
L
---
R
G
-----
M
G
--
G
A
F
----
V
L
V
L
Y
D
E
---
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
59.98
18%
-42
- C4 -
4Q2E
-
CDSA_THEMA
A:
[29-290]
-------------------------------
I
T
-------
A
S
V
V
A
P
F
V
V
-----
L
C
F
---
V
S
-------------------------------------------------------------------------------------
Y
E
S
---
L
I
G
L
V
S
A
I
L
-------
I
L
A
--
G
Y
E
L
I
T
----------------------------
L
----
E
M
-------------------
K
E
R
--------------------
D
A
R
F
F
Y
V
I
------
L
L
A
L
Y
P
V
L
Y
G
L
V
F
E
E
P
-
T
Q
---------
P
L
S
I
L
---
F
I
T
G
V
V
---------
F
S
------
L
-------
I
----
T
---------
D
----------------------------------------
K
D
--
P
S
Q
V
F
K
T
-----
V
-------
A
A
----
F
S
I
--
A
L
---------------------------
I
Y
V
--------------------------------------
T
F
F
L
S
F
F
L
P
----
I
Y
R
D
F
--------
G
A
A
N
A
L
L
V
L
T
S
T
W
-----
V
--
F
-----
D
-----
S
F
---
A
-----
Y
F
T
G
--
L
K
F
G
R
-----
T
R
I
S
P
R
Y
S
P
-
R
-
K
S
L
E
G
V
I
-
G
G
F
L
---
G
V
-----
V
I
-
Y
T
F
L
----
Y
R
L
V
V
N
--------------
D
L
------
L
S
-
V
N
V
I
C
F
R
T
-
F
L
P
F
A
A
T
V
A
I
M
D
---
T
F
G
-
D
I
F
E
-----
C
A
L
K
R
H
Y
G
V
K
---
D
S
G
K
T
---
L
-
P
G
---------------------------
H
G
G
M
L
--
D
----
R
I
D
G
L
L
F
--
V
A
P
--------
V
-
S
-----
Y
I
V
---
F
K
I
L
E
G
V
V
R
----------------------------------------------------------------------------
31
Fugue
55.83
12%
-58
- C5 -
1AFR
-
STAD_RICCO
A:
[1-345]
--------------------------
M
P
P
R
E
V
H
VQVTHSM
P
P
Q
K
I
E
I
F
K
-----
S
L
D
---
N
W
A
E
E
N
-----
I
L
V
H
L
K
----------
P
-------------
V
E
K
--
C
W
Q
P
Q
------
D
F
L
P
D
P
-------
A
S
-------
D
----
G
F
D
E
Q
V
---
R
E
L
R
E
R
A
K
E
-------
I
P
D
--
D
Y
F
V
V
L
--
V
---------------------
G
D
-
M
I
----
T
E
-------------------
E
A
L
--------------------
P
T
Y
Q
T
M
L
N
------
T
------
L
D
G
V
R
D
E
T
G
-
A
S
---------
P
T
S
W
A
---
I
W
T
R
A
W
---------
T
A
------
E
-------
E
----
N
---------
R
H
G
D
L
L
N
K
Y
L
Y
---
L
S
-
G
R
------------------------------------------------------
V
--
D
M
---------------------------
R
Q
I
E
K
T
--
I
Q
Y
L
-
I
G
-----
S
----
G
-----
M
D
P
-----
R
T
E
N
S
P
Y
L
G
F
I
----
Y
T
S
F
Q
--------
E
R
A
T
F
I
S
H
G
N
T
A
R
-----
Q
--
A
-----
K
-----
E
H
---
G
------
D
I
K
--
L
A
Q
I
C
-----
G
T
I
A
A
D
E
K
R
-
H
E
T
A
Y
T
K
I
V
-
E
K
L
F
---
E
I
-----
D
P
-
D
G
T
V
----
L
-
A
F
A
D
M
---
M
R
K
K
I
S
M
P
A
H
L
M
YD----
G
R
-
D
D
N
L
F
D
H
F
-
S
A
V
A
Q
R
L
G
V
Y
T
A
---
K
D
Y
A
D
I
L
E
-----
F
L
V
G
R
W
K
V
D
K
---
L
T
G
L
S
---
A
-
E
G
Q
K
---
A
Q
D
Y
V
---
C
R
L
P
-
P
R
--
I
----
R
R
L
E
E
--
R
----
A
Q
G
R
A
K
E
--
A
P
T
--------
M
-
P
-----
F
S
W
---
I
F
D
R
Q
V
K
L
-----------------------------------------------------------------------------
28
Fugue
55.41
13%
-67
- C2 -
2GIC
-
NCAP_VSIVA
A:
[2-422]
--------------SV
T
V
K
R
IIDN
T
V
I
V
P
K
L
P
A
-------
N
E
D
P
V
E
Y
P
A
-----
D
Y
F
---
R
K
S
K
E
I
-----
P
L
Y
I
N
T
----------
T
-------------
K
S
L
--
S
D
L
R
G
------
Y
V
Y
Q
G
L
K
S
GNVS
I
I
H
V
-
N
S
Y
L
Y
G
----
A
L
K
D
I
R
G
K
L
D
K
D
W
S
S
F
G
I
-------
N
I
G
--
K
A
G
D
T
I
--
G
---------------------
I
F
-
D
L
----
V
S
L
K
A
L
D
G
V
L
P
DGVSDASRTS
A
D
D
--------------------
K
W
L
P
L
Y
L
L
------
G
----
L
Y
R
V
G
R
T
Q
M
P
E
-
Y
R
---------
K
K
L
M
D
---
G
L
T
N
Q
C
---------
K
M
------
I
-------
N
----
E
---------
Q
F
E
P
L
V
P
----------
E
G
-----
R
D
I
F
-------
D
--
V
W
G
N
D
---
S
N
Y
T
K
I
-----
V
-------
A
A
----
V
D
M
--
F
F
---------------------------
H
M
F
K
K
H
EC
A
S
F
R
-
Y
G
-----
T
I
---
V
-----
S
R
------
F
K
D
C
A
A
L
A
T
F
G
----
H
L
C
K
I
--------
T
G
M
S
T
E
D
V
T
T
W
I
L
-----
N
---------------------------
R
E
--
V
A
D
E
M
-----
V
Q
M
M
L
P
G
Q
E
-
I
-
D
K
A
D
S
Y
M
-
P
Y
L
I
---
D
F
GLSSK
S
P
-
Y
S
S
V
----
K
N
P
A
F
H
F
W
G
Q
L
T
A
L
L
L
R
S
T
R
A
R
NA
R
Q
P
D
D
I
-
E
Y
T
S
L
T
T
A
-
G
L
L
Y
A
Y
A
V
G
S
S
A
---
D
L
A
Q
Q
F
C
V
GDNKY
T
P
D
D
S
T
G
G
L
T
---
T
N
A
P
P
---
Q
-
G
R
D
V
---
V
E
W
L
G
---
W
F
E
D
-
Q
N
RK
P
----
T
P
D
M
M
--
Q
----
Y
A
K
R
A
V
M
SL
Q
G
L
--------
R
-
E
-----
K
T
I
---
G
K
Y
A
K
S
E
F
D
K
---------------------------------------------------------------------------
16
HHSearch
53.85
18%
-41
- C4 -
2LCK
-
UCP2_MOUSE
A:
[31-302]
------------------------------------------------
T
-----
F
P
L
---
D
T
A
K
V
R
-----
L
Q
I
Q
G
E
----------
S
QG
L
V
R
T
A
ASAQYR
G
V
L
--
G
T
I
L
T
------
M
V
R
T
E
---------
G
P
-
R
S
L
Y
N
G
----
L
V
A
G
L
Q
---
R
Q
M
S
F
A
S
V
R
-------
I
G
L
--
Y
D
S
V
----
K
---------------------
Q
F
-
Y
T
----
K
G
-------------------
S
E
H
--------------------
A
G
I
G
S
R
L
L
------
A
----
G
S
T
T
G
A
L
A
V
A
V
-
A
Q
---------
P
T
D
V
V
---
K
V
R
F
Q
A
---------
Q
A
------
R
-------
A
GGG-
R
---------
R
Y
Q
S
T
V
E
A
Y
K
T
---
I
A
-
R
E
-----
E
G
I
R
-------
G
--
L
W
K
G
T
--
S
P
N
V
A
R
N
-----
A
-------
I
V
----
N
C
A
--
E
L
---------------------------
V
T
Y
D
L
I
--
K
D
T
L
-
L
K
-----
A
N
L--
M
-----
T
D
D
-----
L
P
C
H
F
T
S
A
F
G
A
----
G
F
C
T
T
--------
V
I
A
S
P
V
D
V
V
K
T
R
Y
-----
M
--
N
-----
S
-----
A
L
---
G
-----
Q
Y
H
S
--
A
G
H
C
A
-----
L
T
M
L
R
K
E
G
P
-
R
-
A
F
Y
K
G
F
M
-
P
S
F
L
---
R
L
-----
G
S
-
W
N
V
V
----
M
F
V
T
Y
E
Q
---
L
K
R
A
L
M
A
A
Y
Q
S
R
------
E
A
-
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.75
27%
-116
- C4 -
2FFI
-
?
A:
[81-165]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
-
L
R
G
V
V
M
L
E
-
R
D
V
E
Q
A
T
L
A
E
M
A
---
R
L
G
V
R
G
V
R
-----
L
N
L
M
G
Q
D
M
P
D
---
L
T
G
A
Q
---
W
-
R
P
L
L
---
E
R
I
-
G
---
E
Q
G
W
H
V
E
--
L
----
H
R
Q
V
A
D
I
P
----
V
L
V
R
A
L
Q
--
P
Y
G
--------
L
-
D
-----
I
V
I
---
D
H
F
G
R
P
D
A
R
R
---------------------------------------------------------------------------