@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S2543_HUMAN: (2015-12-09 )
MATWRRDGRLTGGQRLLCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRAEGLRALWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQPQELRELKKFFKTRKPKPKKPTL
Atome Classification :
(20 SA)
-----------.........10..-------......20......----------..--30.--.......40-------.-----.------.------.-------.---------.------..----50..-......60---.--------------...---.....70-------.-----...-----....--.-----------80--........90.-------....---.--..100-----....--.--..110..--------.-----...-----.120...----..-..130-..---.....140------.--------..---.....---.150.......160.....------..170.......180---------------.-------------...-....190...---..--------------------.-----..200...-...---------------.210..-.---....220.......230......----------.---240.......-------250.--...---------...-----260-----------------.......--..----------------270---....--.------...-280.......290-.---.......300--.....---...310.....------------..320--.....-------------..330......--------..340-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MATWRRDGRLTGG-------
Q
R
L
L
CAGLA
G
T
L
S
L
----------
S
L--TA
P
--
L
E
L
A
T
V
L
A
Q
-------
V
-----
G
------V------V-------R---------G------HA----RGPW-ATG
H
R
V
W
----
R
--------------
A
E
G
---
L
R
A
L
WK--------G-----N
A
V
-----
A
C
L
R
--L-----------FP--C
S
A
V
Q
L
A
A
Y
R
K
-------
F
V
V
L
---
F
--TDDLG-----
H
I
S
Q
--
W
--
S
S
I
M
A
G
S
--------
L
-----
A
G
M
-----
V
S
T
I
V
TY----
P
T
-
D
L
I
K
T
-
R
L
---
I
M
Q
N
IL--------
E
--------
P
S
---
Y
R
G
L
L
---
H
A
F
S
T
I
Y
QQE
G
F
L
A
L
YRG
V
------
S
L
T
V
V
G
ALPFSAG
S
----------------
L
-------------
L
V
Y
-
M
N
L
E
K
-IWNG---PR--------------------D-----QFS
L
P
Q
N
F
-
A
N
V
---------------
C
L
A
A
A
V
-
T
---
Q
T
LSF
P
F
E
T
V
K
R
K
M
QAQSPYLPH----------S---GG
V
D
V
H
FS
G
A
-------
V
D
C
F
--
R
Q
I
---------
V
K
A-----Q-------------------
G
V
L
G
L
W
N
--
G
L
----------------
T
A
----
N
L
L
K
--
I
------
V
P
Y
-
F
G
I
M
F
S
T
F
E
F
C
K
--
R
---
I
C
LYQN
G
Y
I
---LSPL
S
---
Y
KLTPGVDQSL------------
Q
P
Q
E
L
--
R
E
L
K
K
-------------
F
F
K
T-RKPKPK--------KPTL--------------------
3
PsiBlast_PDB
77.37
26%
-78
- C7 -
4C9J
4
ADT3_YEAST
A:
[30-306]
--------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
----------
T
A
--
A
S
P
--
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
K
Q
-----
G
------
T
------
L
-------
D
---------
K
------
K
Y
----
S
G
I
V
-
D
C
F
K
R
T
A
----
K
--------------
Q
E
G
---
L
I
S
F
W
R
--------
G
-----
N
T
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
I
K
L
M
---
F
GF
K
K
E
E
G
-----
Y
-
G
K
--
W
F
A
G
N
L
A
S
G
G
--------
A
-----
A
G
A
-----
L
S
L
L
F
V
Y
----
S
L
-
D
F
A
R
T
-
R
L
---
A
A
D
A
K
S
-------------------ARQ
F
N
G
L
T
---
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
------
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
----------------
F
-------------
G
M
F
-
D
S
L
K
------------------------------------------------
F
---------------
L
L
G
W
V
V
-
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
S
--------------------
G
Q
A
V
K
Y
N
G
A
-------
I
D
C
L
--
K
K
I
---------
V
A
S
-----
E
-------------------
G
V
G
S
L
F
K
--
G
C
----------------
G
A
----
N
I
L
R
--
S
------
V
A
G
-
A
G
V
I
S
M
Y
D
Q
L
Q
M
--
I
---
L
F
G
K
K
F
---------------------------------------------------------------------------------------------------------
24
Fugue
73.26
26%
-74
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------
D
Q
A
L
S
F
L
-------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
----------
T
A
--
V
A
P
--
I
E
R
V
K
L
L
L
Q
-------
V
-----
Q
------
H
ASKQIS
A
-------
E
---------
K
------
Q
Y
----
K
G
I
I
-
D
C
V
V
R
I
P
----
K
--------------
E
Q
G
---
F
L
S
F
W
R
--------
G
-----
N
L
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
Y
K
Q
I
---
F
--
L
G
G
V
D
RHKQ
F
W
R
Y
F
--
A
--
G
N
L
A
S
G
G
--------
A
-----
A
G
A
-----
T
S
L
C
F
V
Y
----
P
L
-
D
F
A
R
T
-
R
L
---
A
A
D
V
G
K
--------
G
--------
A
A
QRE
F
T
G
L
G
---
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
------
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
----------------
F
-------------
G
V
Y
-
D
T
A
K
G
-
M
L
P
D
---
P
K
--------------------
N
-----
V
-
H
I
I
V
S
W
-
M
I
A
---------------
Q
T
V
T
A
V
-
A
---
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
----
G
----------
R
---
K
G
A
D
I
M
Y
T
G
T
-------
V
D
C
W
--
R
K
I
---------
A
K
D
-----
E
-------------------
G
P
K
A
F
F
K
--
G
A
----------------
W
S
----
N
V
L
R
--
G
------
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.24
26%
-82
- C7 -
4C9Q
5
ADT3_YEAST
A:
[30-306]
--------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
----------
T
A
--
A
S
P
--
I
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
K
Q
-----
G
------
T
------
L
-------
D
---------
K
------
K
Y
----
S
G
I
V
-
D
C
F
K
R
T
A
----
K
--------------
Q
E
G
---
L
I
S
F
W
R
--------
G
-----
N
T
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
I
K
L
M
---
F
GF
K
K
E
-
G
-----
Y
-
G
K
--
W
F
A
G
N
L
A
S
G
G
--------
A
-----
A
G
A
-----
L
S
L
L
F
V
Y
----
S
L
-
D
F
A
R
T
-
R
L
---
A
A
D
A
K
S
-------------------ARQ
F
N
G
L
T
---
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
------
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
----------------
F
-------------
G
M
F
-
D
S
L
K
P
L-------------------------------------
F
L
-----
A
S
F
---------------
L
L
G
W
V
V
-
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
S
--------------------
G
Q
A
V
K
Y
N
G
A
-------
I
D
C
L
--
K
K
I
---------
V
A
S
-----
E
-------------------
G
V
G
S
L
F
K
--
G
C
----------------
G
A
----
N
I
L
R
--
S
------
V
A
G
-
A
G
V
I
S
M
Y
D
Q
L
Q
M
--
I
---
L
F
G
K
-----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.90
26%
-63
- C7 -
2C3E
4
ADT1_BOVIN
A:
[9-279]
-------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
----------
T
A
--
V
A
P
--
I
E
R
V
K
L
L
L
Q
-------
V
-----
Q
HASKQI
S
------
A
-------
E
---------
K
------
Q
Y
----
K
G
I
I
-
D
C
V
V
R
I
P
----
K
--------------
E
Q
G
---
F
L
S
F
W
R
--------
G
-----
N
L
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
Y
K
Q
I
---
F
--
L
G
G
V
D
-----
R
H
K
Q
--
F
--
W
R
Y
F
A
G
N
--------
L
A
S
G
G
A
A
G
A
-----
T
S
L
C
F
V
Y
----
P
L
-
D
F
A
R
T
-
R
L
A
A
D
V
G
K
G
A
A
--------
Q
--------
R
E
---
F
T
G
L
G
---
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
------
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
----------------
F
-------------
G
V
Y
-
D
T
A
K
G
-
M
L
P
D
---
P
K
--------------------
N
------
V
H
I
I
V
S
W
-
M
I
A
---------------
Q
T
V
T
A
V
-
A
---
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
--------------
R
---
K
G
A
D
I
M
Y
T
G
T
-------
V
D
C
W
--
R
K
I
---------
A
K
D
-----
E
-------------------
G
P
K
A
F
F
K
--
G
A
----------------
W
S
----
N
V
L
R
--
G
------
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------
15
HHSearch
72.49
26%
-73
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------
D
Q
A
L
S
F
L
-------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
----------
T
A
--
V
A
P
--
I
E
R
V
K
L
L
L
Q
-------
V
-----
Q
------
H
------
A
-------
S
---------
K
QISAEK
Q
Y
----
K
G
I
I
-
D
C
V
V
R
I
P
----
K
--------------
E
Q
G
---
F
L
S
F
W
R
--------
G
-----
N
L
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
Y
K
Q
I
---
F
--
L
G
G
V
D
RHKQ
F
W
R
Y
F
--
A
--
G
N
L
A
S
G
G
--------
A
-----
A
G
A
-----
T
S
L
C
F
V
Y
----
P
L
-
D
F
A
R
T
-
R
L
---
A
A
D
V
G
K
GAA-----
Q
--------
R
E
---
F
T
G
L
G
---
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
------
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
----------------
F
-------------
G
V
Y
-
D
T
A
K
G
-
M
L
P
D
---
P
K
--------------------------
N
V
H
I
I
V
S
W
-
M
I
A
---------------
Q
T
V
T
A
V
-
A
---
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
R
K
-----------------
G
A
D
I
M
Y
T
G
T
-------
V
D
C
W
--
R
K
I
---------
A
K
D
-----
E
-------------------
G
P
K
A
F
F
K
--
G
A
----------------
W
S
----
N
V
L
R
--
G
------
M
G
--
G
A
F
V
L
V
L
Y
D
E
I
----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.48
26%
-66
- C7 -
1OKC
10
ADT1_BOVIN
A:
[9-279]
-------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
----------
T
A
--
V
A
P
--
I
E
R
V
K
L
L
L
Q
-------
V
-----
Q
HASKQI
S
------
A
-------
E
---------
K
------
Q
Y
----
K
G
I
I
-
D
C
V
V
R
I
P
----
K
--------------
E
Q
G
---
F
L
S
F
W
R
--------
G
-----
N
L
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
Y
K
Q
I
---
F
--
L
G
G
V
D
-----
R
H
K
Q
--
F
--
W
R
Y
F
A
G
N
--------
L
A
S
G
G
A
A
G
A
-----
T
S
L
C
F
V
Y
----
P
L
-
D
F
A
R
T
-
R
L
A
A
D
V
G
K
G
A
A
--------
Q
--------
R
E
---
F
T
G
L
G
---
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
------
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
----------------
F
-------------
G
V
Y
-
D
T
A
K
G
-
M
L
P
D
---
P
K
--------------------
N
------
V
H
I
I
V
S
W
-
M
I
A
---------------
Q
T
V
T
A
V
-
A
---
G
L
V
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
--------------
R
---
K
G
A
D
I
M
Y
T
G
T
-------
V
D
C
W
--
R
K
I
---------
A
K
D
-----
E
-------------------
G
P
K
A
F
F
K
--
G
A
----------------
W
S
----
N
V
L
R
--
G
------
M
G
G
-
A
F
V
L
V
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------
25
Fugue
72.35
17%
-86
* C8 *
2Q06
-
?
A:
[22-496]
----------A
T
E
I
R
A
S
V
G
R
M
V
G
G
-------
I
G
R
F
Y
I
Q
M
C
T
E
L
K
L
----------
S
D
--
Q
E
G
--
R
L
I
Q
N
S
I
T
I
-------
E
-----
R
------
M
------
V
L
S
A
F
DER
R
---------
N
------
R
Y
----
K
D
P
K
-
K
T
G
G
P
I
Y
----
R
RRD
G
K
W
V
R
E
L
I
L
Y
D
K
E
E
---
I
R
R
I
W
R
Q
A
N
NGEDA
T
-----
A
G
L
-----
T
H
M
M
--
I
-----------
W
H
--
S
N
L
N
D
A
T
Y
Q
R
T
-------
R
A
L
V
R
T
G
M
--
D
P
R
M
C
-----
S
L
M
Q
--
G
--
S
T
L
P
R
R
S
--------
G
-----
A
A
G
A
A
I
KG
V
G
T
M
V
M
E
----
L
I
-
R
M
I
K
R
-
G
I
---
N
D
R
N
F
W
--------
R
GENG
R
R
T
R
I
A
---
Y
E
R
M
C
---
N
I
L
K
G
K
F
Q
T
A
A
Q
K
A
M
M
D
Q
V
R
E
SRNP
G
N
A
E
I
E
D
L
I
F
L
A
R
S
A
L
I
LRGS
I
A
H
K
S
C
L
P
A
C
-------------
V
Y
G
-
L
A
V
A
S
-
G
Y
D
F
---
E
R
--------------------
E
-----
G
Y
S
L
V
G
I
D
-
P
F
R
---------------
L
L
Q
N
S
Q
-
V
---
F
S
L
I
R
P
N
E
N
P
A
H
K
S
Q
L
V
W
M
A
C
H
S
----------
A
---
A
F
E
D
L
R
V
S
S
F
-------
I
R
G
T
--
R
V
I
---------
P
R
G
-----
Q
LSTRGVQIASNENVEA
M
D
S
S
T
L
E
L
R
S
--
R
Y
W
A
I
R
T
RSG
G
N
T
N
Q
Q
RA
S
A
----
G
Q
I
S
--
V
------
Q
P
T
-
F
S
V
Q
R
N
L
P
F
E
R
A
--
T
---
I
M
A
A
F
K
G
N
T
EGR
T
S
D
M
R
---
T
E
I
I
R
M
M
E
S
A
R
------------
P
E
D
V
S
--
F
Q
G
R
G
-------------
V
F
E
L
-
S
D
E
K
A
T
--------
N
P
I
V
P
S
F
DMSNEGSYFFGDNAEEY
5
PsiBlast_PDB
71.36
25%
-83
- C7 -
4C9H
5
ADT2_YEAST
A:
[27-302]
---------------------------------
F
L
M
G
G
V
S
A
A
V
A
K
----------
T
A
--
A
S
P
--
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
K
Q
-----
G
------
T
------
L
-------
D
---------
R
------
K
Y
----
A
G
I
L
-
D
C
F
K
R
T
A
----
T
--------------
Q
E
G
---
V
I
S
F
W
R
--------
G
-----
N
T
A
-----
N
V
I
R
--
Y
-----------
F
P
--
T
Q
A
L
N
F
A
F
K
D
K
-------
I
K
A
M
---
F
G
F
K
K
E
E
G
-----
Y
-
A
K
--
W
F
A
G
N
L
A
S
G
G
--------
A
-----
A
G
A
-----
L
S
L
L
F
V
Y
----
S
L
-
D
Y
A
R
T
-
R
L
---
A
A
D
S
---------------------ARQ
F
N
G
L
I
---
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
G
F
------
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
----------------
F
-------------
G
M
Y
-
D
S
L
K
-----------------------------------------
L
A
S
F
-
L
L
G
---------------
W
V
V
T
T
G
-
A
---
S
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
T
S
--------------------
G
Q
A
V
K
Y
D
G
A
-------
F
D
C
L
--
R
K
I
---------
V
A
A
-----
E
-------------------
G
V
G
S
L
F
K
--
G
C
----------------
G
A
----
N
I
L
R
--
G
------
V
A
G
-
A
G
V
I
S
M
Y
D
Q
L
Q
M
--
I
---
L
F
G
K
K
F
K
--------------------------------------------------------------------------------------------------------
26
Fugue
70.85
18%
-76
- C5 -
4RKS
2
MV3K_THEAC
A:
[21-337]
-------------
T
Y
R
S
I
G
S
T
A
Y
--------
P
T
I
G
V
V
L
L
G
G
I
A
N
P
----------
V
T
--
R
T
P
--
L
H
-----
T
S
-------
A
-----
G
------
I
------
A
-------
Y
---------
S
------
D
S
----
C
G
S
I
-
R
S
E
T
R
I
Y
----
A
--------------
D
E
A
---
T
H
I
Y
F
N
--------
G
-----
T
E
S
TDDNR
S
V
R
R
--
V
-----------
L
D
R
Y
S
S
V
F
E
E
A
F
G
T
K
-------
T
V
S
Y
---
S
--
S
Q
N
F
G
-----
I
L
S
G
--
S
--
S
D
A
G
A
A
S
--------
I
-----
G
A
A
-----
I
L
G
L
K
P
-----
D
L
-
D
P
H
D
V
-
E
N
---
D
L
R
A
V
S
--------
E
--------
S
A
---
G
R
S
L
F
---
G
G
L
T
I
T
W
S
D
G
-----
F
H
A
Y
------
T
E
K
I
L
D
P
E
A
F
S
G
Y
S
----------------
I
-------------
V
A
F
-
A
-----------------------------------------
F
D
Y
Q
R
N
P
-
S
D
V
---------------
I
H
Q
N
I
V
-
R
---
S
D
L
---
Y
P
A
R
K
K
H
A
D
E
H
A
H
M
I
K
E
----------
Y
A
K
T
N
D
I
K
G
I
F
D
L
A
Q
E
D
----
T
E
E
Y
--
H
S
I
---------
L
R
G
-----
V
-------------------
G
V
----
N
--
V
I
----------------
R
E
----
N
M
Q
K
--
L
------
I
S
Y
-
L
K
L
I
R
K
D
--------------
Y
W
N
A
Y
I
---
V
T
G
-
G
---
S
N
V
Y
V
A
V
E
-
S
E
------------
N
A
D
R
L
--
F
S
I
E
N
-------------
T
F
G
S
-
K
K
K
M
L
R
I
V
G
G
A
W
H
R
R
P
E
---------------------
14
HHSearch
68.26
24%
-64
- C7 -
2LCK
-
UCP2_MOUSE
A:
[14-304]
-----------------------
T
-------
V
K
F
L
G
A
G
T
A
A
C
I
A
D
----------
L
I
--
T
F
P
--
L
D
T
A
K
V
R
L
Q
-------
I
-----
Q
------
G
------
E
-------
S
QG
L
V
R
T
A
AS
A
------
Q
Y
----
R
G
V
L
-
G
T
I
L
T
M
V
----
R
--------------
T
E
G
---
P
R
S
L
Y
N
--------
G
-----
L
V
A
-----
G
L
Q
R
--
Q
-----------
M
S
--
F
A
S
V
R
I
G
L
Y
D
S
-------
V
K
Q
F
---
Y
--
T
K
G
S
E
-----
H
A
G
I
--
G
--
S
R
L
L
A
G
S
--------
T
-----
T
G
A
-----
L
A
V
A
V
A
Q
----
P
T
-
D
V
V
K
V
-
R
F
---
Q
A
Q
A
R
A
GG------
G
--------
R
R
---
Y
Q
S
T
V
---
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
------
S
P
N
V
A
R
N
A
I
V
N
C
A
E
----------------
L
-------------
V
T
Y
-
D
L
I
K
D
-
T
L
L
K
---
A
N
L-------------------
M
-----
T
D
D
L
P
C
H
F
-
T
S
A
---------------
F
G
A
G
F
C
-
T
---
T
V
I
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
G
----------------------
Q
Y
H
S
A
-------
G
H
C
A
--
L
T
M
---------
L
R
K
-----
E
-------------------
G
P
R
A
F
Y
K
--
G
F
----------------
M
P
----
S
F
L
R
--
L
------
G
S
W
-
N
V
V
M
F
V
T
Y
E
Q
L
K
--
R
---
A
L
M
A
A
Y
Q
S
R
---
E
A
P
F
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.41
25%
-57
- C7 -
2LCK
-
UCP2_MOUSE
A:
[16-304]
--------------------------------
K
F
L
G
A
G
T
A
A
C
I
A
D
----------
L
I
--
T
F
P
--
L
D
T
A
K
V
R
L
Q
-------
I
QGESQ
G
------
L
------
V
-------
R
---------
T
------
A
A
SAQY
R
G
V
L
-
G
T
I
L
T
M
V
----
R
--------------
T
E
G
---
P
R
S
L
Y
N
--------
G
-----
L
V
A
-----
G
L
Q
R
--
Q
-----------
M
S
--
F
A
S
V
R
I
G
L
Y
D
S
-------
V
K
Q
F
---
Y
--
T
K
G
S
E
-----
H
A
G
I
--
G
--
S
R
L
L
A
G
S
--------
T
-----
T
G
A
-----
L
A
V
A
V
A
Q
----
P
T
-
D
V
V
K
V
-
R
F
---
Q
A
Q
A
R
A
--------
G
--------
G
G
RR-
Y
Q
S
T
V
---
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
------
S
P
N
V
A
R
N
A
I
V
N
C
A
E
----------------
L
-------------
V
T
Y
D
L
I
K
D
T
-
L
L
K
A
---
N
L
--------------------
M
-----
T
D
D
L
P
C
H
F
-
T
S
A
---------------
F
G
A
G
F
C
-
T
---
T
V
I
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
G
Q
Y
H
----------
S
---
A
G
----------------
H
C
A
--
L
T
M
---------
L
R
K
-----
E
-------------------
G
P
R
A
F
Y
K
--
G
F
----------------
M
P
----
S
F
L
R
--
L
------
G
S
W
-
N
V
V
M
F
V
T
Y
E
Q
L
K
--
R
AL-
M
A
A
Y
Q
S
R
E
A
---
P
F
-------------------------------------------------------------------------------------------------
28
Fugue
64.66
14%
-102
- C3 -
1V9D
-
DIAP1_MOUSE
A:
[6-337]
--------------------------------------
V
K
E
L
K
V
L
----------
D
S
--
K
T
A
--
Q
N
L
S
I
F
L
G
S
-------
F
-----
R
------
M
------
P
-------
Y
---------
Q
------
E
I
----
K
N
V
I
-
L
E
V
N
E
-----------------------------
A
V
L
T
--------
E
-----
S
M
I
-----
Q
N
L
I
--
K
-----------
Q
M
--
P
E
P
E
Q
L
K
M
L
S
E
-------
L
-
K
E
---
E
--
Y
D
D
L
A
-----
E
S
E
Q
--
F
--
G
V
V
M
G
-
T
--------
V
-----
P
R
L
-----
R
P
R
L
N
A
I
----
L
F
-
K
L
Q
F
S
-
E
Q
---
V
E
N
--
I
--------
K
--------
P
E
---
I
V
S
V
T
---
A
A
C
E
E
L
R
K
S
E
N
F
S
S
L
L
S
--------
F
L
C
K
L
R
D
T
K
S
A
D
Q
K
----------------
M
T------------
L
L
H
-
F
L
A
E
L
-
C
E
N
D
---
H
P
--------------------
E
-----
V
L
K
F
P
D
E
L
-
A
H
V
---------------
E
K
A
S
R
V
S
A
---
E
N
L
Q
K
S
L
D
Q
M
K
K
Q
I
A
D
V
E
R
D
V
Q
N
----------
F
---
P
A
A
T
D
E
K
D
K
F
-------
V
E
K
M
--
T
S
F
---------
V
K
D
A
Q
E
Q
Y
N
-------------------
K
L
R
M
M
H
S
--
N
M
----------------
E
T
----
L
Y
K
E
--
L
------
G
D
Y
-
F
V
F
D
P
K
K
L
S
-----------
V
E
E
F
F
M
D
---
L
H
N
F
R
---
N
M
F
L
Q
A
V
K
E
N
Q
------------
K
R
R
E
T
--
E
E
K
M
R
-------------
R
A
K
L
-
A
K
E
K
A
E
--------
K
E
R
L
--------------------
30
Fugue
62.14
16%
-94
- C4 -
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
-------
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
----------
E
L
--
I
A
S
E
N
F
A
S
R
A
V
L
E
A
-------
L
-----
G
------
S
------
C
-------
L
---------
N
------
N
K
----
Y
S
E
G
-
Y
P
G
Q
R
Y
Y
GGT
E
F
--------------
I
D
E
---
L
E
T
L
C
Q
--------
K
-----
R
A
L
-----
Q
A
Y
K
--
L
DPQC
W
G
V
N
VQP
Y
S
--
G
S
P
A
N
F
A
V
Y
T
A
LVEPH
G
R
I
M
G
L
---
D
--
L
P
D
G
G
-----
H
L
T
H
G
F
M
--
T
D
K
K
K
I
S
--------
A
-----
T
S
I
-----
F
F
E
S
M
P
Y
K
V
NP
D
T
-
G
Y
I
N
Y
-
D
Q
---
L
E
E
N
A
R
--------
L
--------
F
H
---
P
K
L
I
I
AGT
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
------
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
----------------
V
A
A
GVVPSPFEHCH
V
V
T
-
T
T
T
H
K
-
T
L
R
G
---
C
R
A
G
M
I
F
Y
R
K
G
VKSVDPATG
K
E
I
-----
L
Y
N
L
E
S
L
I
-
N
S
A
V
F
PGLQGGPH
N
H
A
I
A
G
V
A
V
A
L
-
K
---
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
T
E
L
GYKIV
T
---
G
G
S
D
N
H
L
I
L
--------
V
D
L
R
--
S
K
G
---------
T
D
G
-----
G
-------------------
R
A
E
K
V
L
E
A
C
S
I
----------------
A
C
----
N
K
N
T
--
C
PGDRSA
L
R
P
-
S
G
L
R
L
G
T
P
A
L
T
S
--
R
GLL
E
K
D
F
Q
K
V
A
H
---
F
I
H
R
G
---
I
E
L
T
L
Q
I
Q
S
D
T
G-----------
V
A
A
T
L
--
K
E
F
K
E
-------------
R
L
A
G
-
D
K
Y
Q
A
A
--------
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
PLPGL----
17
HHSearch
60.96
20%
-42
- C7 -
1OKC
8
ADT1_BOVIN
A:
[5-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
--
L
--
K
D
F
L
A
G
G
--------
V
-----
A
A
A
-----
I
S
K
T
A
V
A
----
P
I
-
E
R
V
K
L
-
L
L
---
Q
V
Q
H
A
S
KQISA---
E
--------
K
Q
---
Y
K
G
I
I
---
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
G
N
------
L
A
N
V
I
R
Y
F
P
T
Q
A
L
N
----------------
F
-------------
A
F
K
-
D
K
Y
K
Q
-
I
F
L
G
---
G
V
--------------------
D
RHKQ
F
W
R
Y
F
A
G
N
L
-
A
S
G
---------------
G
A
A
G
A
T
-
S
---
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
-----------------
A
A
Q
R
E
F
T
G
L
-------
G
N
C
I
--
T
K
I
---------
F
K
S
-----
D
-------------------
G
L
R
G
L
Y
Q
--
G
F
----------------
N
V
----
S
V
Q
G
--
I
------
I
I
Y
-
R
A
A
Y
F
G
V
Y
D
T
A
K
--
G
---
M
L
P
D
P
K
N
V
H
I
--
I
V
S
W
M
---
I
A
Q
T
V
T
A
V
A
G
L
------------
V
S
Y
P
F
--
D
T
V
R
R
-------------
R
M
M
M
-
Q
S
G
R
K
G
--------
A
D
I
M
--------------------
29
Fugue
56.97
17%
-77
- C8 -
2IQH
-
?
A:
[21-489]
---------NA
T
E
I
R
A
S
V
G
K
M
I
D
G
-------
I
G
R
F
Y
I
Q
M
C
T
E
L
K
L
S
D
Y
E
G
R
L
I
Q
N
S
L
--
T
I
E
--
R
M
V
L
S
A
F
D
T
-------
G
-----
G
------
P
------
I
-------
Y
---------
R
------
R
V
----
D
G
K
W
-
R
R
E
L
I
L
Y
----
D
--------------
K
E
E
---
I
R
R
I
W
R
--------
Q
A
N
N
GD
D
A
T
-----
A
G
L
T
H
M
M
-----------
I
W
--
H
S
N
L
N
D
A
T
Y
Q
R
-------
T
R
A
L
---
V
--
R
T
G
M
D
-------
P
R
--
M
--
C
S
L
M
Q
G
S
TLPRRSG
A
A
-----
G
A
A
-----
V
K
G
V
G
T
M
----
V
M
-
E
L
I
R
M
I
K
R
---
G
I
N
R
R
T
--------
R
--------
I
A
---
Y
E
R
M
C
---
N
I
L
K
G
K
F
Q
T
A
A
Q
R
T
M
V
D
Q
V
R
ESRNP
G
N
A
E
F
E
D
L
I
F
L
A
R
S
A
L
ILR
G
S
V
A
H
K
SC---
L
-------------
P
A
C
-
V
Y
G
S
A
-
V
A
S
G
YDF
E
R
--------------------
E
-----
G
Y
S
L
V
G
I
D
-
P
F
R
---------------
L
L
Q
N
S
Q
-
V
---
Y
S
L
I
R
P
N
E
N
P
A
H
K
S
Q
L
V
W
M
A
C
H
S
----------
A
---
A
F
E
D
L
R
V
S
S
F
-------
I
R
G
T
--
K
V
V
PRGKLSTRG
V
Q
I
-----
A
-------------------
S
N
E
N
M
E
T
--
M
E
----------------
S
S
----
T
L
E
L
--
R
------
S
R
Y
-
W
A
I
R
T
R
S
G
G
N
T
S
SG
Q
---
I
S
I
Q
P
T
F
S
V
---
Q
R
N
L
P
---
F
D
R
P
T
I
M
A
A
S
D
------------
M
R
T
E
I
--
I
R
L
M
E
S
ARPEDVSFQG
R
G
V
F
E
L
-
S
D
E
K
A
T
--------
S
P
I
V
P
S
FDMSNEGSYFF-------
33
Fugue
55.80
14%
-92
- C6 -
1I4W
3
MTF1_YEAST
A:
[16-337]
----------P
I
P
G
I
K
D
I
S
K
L
K
F
F
YG
F
K
Y
L
W
N
P
T
V
Y
N
K
I
F
D
K
L
D
L
----------
T
K
--
T
Y
K
--
H
P
E
E
L
K
V
L
D
-------
L
-----
Y
------
P
--------------------------------------
G
V
G
-
I
Q
S
A
I
F
Y
----
N
--------------
K
Y
C
---
P
----
R
--------
Q
-----
Y
S
L
-----
L
E
K
R
--
S
-----------
S
L
--
Y
K
F
L
N
A
K
F
E
G
S
-------
P
L
Q
I
---
L
--
K
R
D
P
Y
-----
D
W
S
T
--
Y
--
S
N
L
I
D
E
E
---------------
R
I
-----
F
V
P
E
V
Q
S
----
S
D
-
H
I
N
D
K
-
F
L
---
T
V
A
N
V
T
--------
G
--------
E
G
---
S
E
G
L
I
---
M
Q
W
L
S
C
I
G
N
K
N
W
L
Y
R
F
-
G
K
------
V
K
M
L
L
W
M
P
S
T
T
A
R
K
----------------
L
-------------
L
A
R
-
P
G
------
M
H
---
S
R
--------------------
S
-----
K
C
S
V
V
R
E
A
F
T
D
T
---------------
K
L
I
A
I
S
-
D
---
A
N
E
L
K
G
F
D
--
S
Q
C
I
E
E
W
D
P
I
L
F
S
----------
A
---
A
E
I
W
P
T
---------------------------------------------------------------
K
--
G
K
----------------
P
I
----
A
L
V
E
--
M
------
D
P
I
D
F
D
F
D
V
D
N
W
D
Y
V
T
--
R
---
H
L
M
I
L
K
R
T
P
---
L
N
T
V
M
---
D
S
L
G
H
G
G
Q
Q
Y
F
N
S
R
ITDKDLLKK
C
P
I
D
L
T
N
D
E
F
I
Y
-------------
L
T
K
L
-
F
M
E
W
P
F
--------
K
P
----------------------
16
HHSearch
53.97
19%
-59
- C7 -
2LCK
-
UCP2_MOUSE
A:
[15-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
G
A
G
--------
T
-----
A
A
C
-----
I
A
D
L
I
T
F
----
P
L
-
D
T
A
K
V
-
R
L
---
Q
I
Q
G
E
S
QG
L
V
R
T
A
A
S
--------
A
Q
---
Y
R
G
V
L
---
G
T
I
L
T
M
V
R
T
E
G
P
R
S
L
Y
N
G
L
------
V
A
G
L
Q
R
Q
M
S
F
A
S
V
R
----------------
I
-------------
G
L
Y
-
D
S
V
K
Q
-
F
Y
T
K
---
G
S
--------------------
E
-----
H
A
G
I
G
S
R
L
-
L
A
G
---------------
S
T
T
G
A
L
-
A
---
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
------------------
G
G
R
R
Y
Q
S
T
-------
V
E
A
Y
--
K
T
I
---------
A
R
E
-----
E
-------------------
G
I
R
G
L
W
K
--
G
T
----------------
S
P
----
N
V
A
R
--
N
------
A
I
V
-
N
C
A
E
L
V
T
Y
D
L
I
K
--
D
---
T
L
L
K
A
N
L
M
T
---
D
D
L
P
C
H
F
T
S
A
F
G
A
G
F
C
T
T
V
------------
I
A
S
P
V
--
D
V
V
K
T
-------------
R
Y
M
N
-
S
A
L
G
Q
Y
--------
H
S
A
G
--------------------
32
Fugue
50.01
15%
-62
- C2 -
2VIU
5
?
A:
[9-328]
-----------------------
S
-------
T
A
T
L
C
L
G
H
H
A
V
P
N
G
----------
T
L
V
K
T
I
T
--
D
D
Q
I
E
V
T
N
A
-------
T
-----
E
------
L
------
V
-------
Q
---------
S
------
S
S
----
T
G
K
I
C
N
N
P
H
R
I
L
----
D
--------------
G
I
D
CT
L
I
D
A
L
L
---------
G
-----
D
-------------------------
P
H
--
C
D
V
F
Q
N
E
T
W
D
-----------
L
---
F
--
V
E
R
S
K
-----
A
F
S
N
--
C
--
Y
P
Y
D
V
P
D
--------
Y
-----
A
S
L
-----
R
S
L
V
A
S
S
----
G
T
L
E
F
I
T
E
-
G
F
---
T
W
T
G
V
I
--------
Q
N
G
------
G
S
---
N
A
C
K
R
---
G
P
G
S
G
F
F
S
R
L
N
W
L
T
K
S
G
S
T
------
Y
P
V
L
N
V
T
M
P
N
N
D
N
F
----------------
D
-------------
K
L
Y
-
I
W
G
I
H
-
H
P
S
T
---
N
Q
--------------------
E
-----
Q
T
S
L
Y
------
V
---------------
Q
A
S
G
R
V
-
T
---
V
S
T
R
R
S
Q
Q
T
I
I
P
N
I
G
S
R
P
W
V
R
G
L
----------
S
---
S
R
I
S
I
Y
W
T
I
V
K
PG
D
V
L
V
I
N
S
N
--
G
N
L
---------
I
A
P
-----
R
-------------------
G
Y
F
K
M
R
T
--
G
K
----------------
S
S
----
I
M
R
S
--
D
------
A
P
---------
I
D
T
C
I
--
S
---
E
C
I
T
P
N
G
S
I
---
P
N
D
K
P
---
F
Q
N
V
N
K
I
T
Y
G
A
------------
C
P
K
Y
V
--
K
Q
N
T
L
-------------
K
L
A
T
G
M
R
N
V
P
E
--------
K
Q
T
---------------------
12
PsiBlast_PDB
43.84
28%
-53
- C7 -
1XLS
2
NR1I3_MOUSE
E:
[40-144]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
F
Q
P
R
G
P
V
L
P
-----------------
L
L
T
H
F
A
D
--------
I
N
T
F
MV
Q
Q
I
---------
I
K
F
-----
T
-------------------
K
D
L
P
L
F
R
--
S
L
----------------
T
M
EDQI
S
L
L
K
GA
A
------
V
E
I
-
L
H
I
S
L
N
T
-------
T
---
F
C
L
Q
T
E
N
F
F
---
C
G
P
L
C
---
Y
K
M
E
D
A
V
H
A
G
F
------------
Q
Y
E
F
L
--
E
S
I
L
H
-------------
F
H
K
N
-
L
K
G
L
H
L
--------
Q
E
P
E
--------------------
11
PsiBlast_PDB
41.41
28%
-53
- C7 -
1XNX
1
NR1I3_MOUSE
A:
[54-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
F
Q
P
R
G
P
V
L
P
-----------------
L
L
T
H
F
A
D
--------
I
N
T
F
M
V
Q
Q
I
---------
I
K
F
-----
T
-------------------
K
D
L
P
L
F
R
--
S
L
----------------
T
M
E
D
Q
I
S
L
L
K
G
A
A
------
V
E
I
-
L
H
I
S
L
N
T
-------
T
---
F
C
L
Q
T
E
N
F
F
---
C
G
P
L
C
---
Y
K
M
E
D
A
V
H
A
G
F
------------
Q
Y
E
F
L
--
E
S
I
L
H
-------------
F
H
K
N
-
L
K
G
L
H
L
--------
Q
E
P
E
--------------------